KCNA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.95885201
2sarcoplasmic reticulum calcium ion transport (GO:0070296)9.84029397
3skeletal muscle adaptation (GO:0043501)9.70564046
4plasma membrane repair (GO:0001778)7.93120782
5actin filament-based movement (GO:0030048)7.49091182
6skeletal muscle fiber development (GO:0048741)7.42443672
7sarcomere organization (GO:0045214)6.90247719
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.85458055
9pyrimidine ribonucleoside catabolic process (GO:0046133)6.53143305
10striated muscle contraction (GO:0006941)6.48795515
11cytidine metabolic process (GO:0046087)6.44171955
12cytidine catabolic process (GO:0006216)6.44171955
13cytidine deamination (GO:0009972)6.44171955
14myotube cell development (GO:0014904)6.29247265
15myofibril assembly (GO:0030239)6.26237123
16creatine metabolic process (GO:0006600)6.17603743
17skeletal muscle tissue regeneration (GO:0043403)6.10489136
18glycogen catabolic process (GO:0005980)6.02179799
19striated muscle atrophy (GO:0014891)5.98435188
20response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.83847481
21carnitine shuttle (GO:0006853)5.66423877
22glucan catabolic process (GO:0009251)5.62661139
23response to muscle activity (GO:0014850)5.62379838
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.60700679
25regulation of cell communication by electrical coupling (GO:0010649)5.60606250
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.49385058
27cellular polysaccharide catabolic process (GO:0044247)5.35772171
28muscle contraction (GO:0006936)5.33207214
29muscle atrophy (GO:0014889)5.20254590
30purine nucleotide salvage (GO:0032261)5.17467241
31striated muscle adaptation (GO:0014888)5.13950465
32polysaccharide catabolic process (GO:0000272)5.11023182
33behavioral response to nicotine (GO:0035095)5.08650572
34response to inactivity (GO:0014854)5.03144404
35negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.99629640
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.81393717
37muscle system process (GO:0003012)4.79258544
38fatty acid transmembrane transport (GO:1902001)4.78647528
39actomyosin structure organization (GO:0031032)4.70554226
40glycogen biosynthetic process (GO:0005978)4.69684432
41glucan biosynthetic process (GO:0009250)4.69684432
42IMP metabolic process (GO:0046040)4.67774722
43muscle fiber development (GO:0048747)4.63391857
44regulation of relaxation of muscle (GO:1901077)4.44587002
45muscle adaptation (GO:0043500)4.39657481
46regulation of acyl-CoA biosynthetic process (GO:0050812)4.32758194
47positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.23661415
48carnitine transmembrane transport (GO:1902603)4.13195026
49cardiac muscle contraction (GO:0060048)4.04411334
50regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.00893147
51glycogen metabolic process (GO:0005977)3.99323687
52cellular glucan metabolic process (GO:0006073)3.90949382
53glucan metabolic process (GO:0044042)3.90949382
54regulation of coenzyme metabolic process (GO:0051196)3.86594341
55regulation of cofactor metabolic process (GO:0051193)3.86594341
56negative regulation of potassium ion transmembrane transport (GO:1901380)3.86168008
57response to activity (GO:0014823)3.84312645
58ubiquinone biosynthetic process (GO:0006744)3.83344548
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.82691469
60regulation of skeletal muscle cell differentiation (GO:2001014)3.76061572
61carnitine transport (GO:0015879)3.75532751
62amino-acid betaine transport (GO:0015838)3.75532751
63cardiac myofibril assembly (GO:0055003)3.71629568
64negative regulation of cAMP-mediated signaling (GO:0043951)3.66907039
65tricarboxylic acid cycle (GO:0006099)3.65489709
66negative regulation of muscle hypertrophy (GO:0014741)3.64748314
67muscle organ development (GO:0007517)3.64043490
68striated muscle cell development (GO:0055002)3.63603415
69regulation of hexokinase activity (GO:1903299)3.60920127
70regulation of glucokinase activity (GO:0033131)3.60920127
71muscle structure development (GO:0061061)3.59785033
72negative regulation of skeletal muscle tissue development (GO:0048642)3.56043914
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.55785520
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.53419721
75muscle cell cellular homeostasis (GO:0046716)3.52958169
76regulation of actin filament-based movement (GO:1903115)3.45694847
77regulation of striated muscle contraction (GO:0006942)3.45420199
78cellular carbohydrate catabolic process (GO:0044275)3.44917040
79skeletal muscle tissue development (GO:0007519)3.43263719
80ubiquinone metabolic process (GO:0006743)3.42601794
81kynurenine metabolic process (GO:0070189)3.41032330
82L-fucose catabolic process (GO:0042355)3.39909990
83fucose catabolic process (GO:0019317)3.39909990
84L-fucose metabolic process (GO:0042354)3.39909990
85positive regulation of myotube differentiation (GO:0010831)3.35606713
86negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33671329
87neuronal action potential propagation (GO:0019227)3.32916832
88IMP biosynthetic process (GO:0006188)3.32557238
89cellular ketone body metabolic process (GO:0046950)3.31944995
90heart contraction (GO:0060047)3.31430265
91heart process (GO:0003015)3.31430265
92response to pheromone (GO:0019236)3.28634235
93regulation of calcium ion transmembrane transporter activity (GO:1901019)3.26657627
94regulation of calcium ion transmembrane transport (GO:1903169)3.26657627
95platelet dense granule organization (GO:0060155)3.24529695
96positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.24385749
97detection of light stimulus involved in sensory perception (GO:0050962)3.22031184
98detection of light stimulus involved in visual perception (GO:0050908)3.22031184
99cardiac muscle cell development (GO:0055013)3.19170826
100axoneme assembly (GO:0035082)3.15357887
101DNA deamination (GO:0045006)3.14855823
102water-soluble vitamin biosynthetic process (GO:0042364)3.13582522
103mitochondrial respiratory chain complex I assembly (GO:0032981)3.12846101
104NADH dehydrogenase complex assembly (GO:0010257)3.12846101
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12846101
106synaptic transmission, cholinergic (GO:0007271)3.12589183
107negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.12180813
108regulation of sulfur metabolic process (GO:0042762)3.08189552
109muscle cell development (GO:0055001)3.06139698
110myotube differentiation (GO:0014902)3.05134780
111positive regulation of myoblast differentiation (GO:0045663)3.04662835
112intracellular lipid transport (GO:0032365)3.03942541
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03814425
114ketone body metabolic process (GO:1902224)3.02927936
115cellular response to dexamethasone stimulus (GO:0071549)3.02592402
116quinone biosynthetic process (GO:1901663)3.01629003
117cardiac cell development (GO:0055006)2.99689542
118protein complex biogenesis (GO:0070271)2.99686495
119regulation of sequestering of triglyceride (GO:0010889)2.98376635
120auditory receptor cell stereocilium organization (GO:0060088)2.98335830
121positive regulation of sodium ion transmembrane transport (GO:1902307)2.96766924
122adenosine metabolic process (GO:0046085)2.95499866
123respiratory chain complex IV assembly (GO:0008535)2.91719709
124cornea development in camera-type eye (GO:0061303)2.88242745
125neuronal action potential (GO:0019228)2.86466102
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85985816
127indole-containing compound catabolic process (GO:0042436)2.85789109
128indolalkylamine catabolic process (GO:0046218)2.85789109
129tryptophan catabolic process (GO:0006569)2.85789109
130positive regulation of cation channel activity (GO:2001259)2.85773063
131syncytium formation (GO:0006949)2.85368801
132regulation of sarcomere organization (GO:0060297)2.84596364
133regulation of myoblast differentiation (GO:0045661)2.84521834
134neuromuscular synaptic transmission (GO:0007274)2.83591618
135piRNA metabolic process (GO:0034587)2.83430078
136membrane depolarization during action potential (GO:0086010)2.82677466
137indolalkylamine metabolic process (GO:0006586)2.78892606
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.73869039
139proline transport (GO:0015824)2.72570597
140protein polyglutamylation (GO:0018095)2.69913363
141mitochondrial respiratory chain complex assembly (GO:0033108)2.64512447
142alanine transport (GO:0032328)2.62675337
143regulation of action potential (GO:0098900)2.61660088
144cytochrome complex assembly (GO:0017004)2.59578234
145aspartate family amino acid catabolic process (GO:0009068)2.58863236
146protein K11-linked deubiquitination (GO:0035871)2.57577046
147dopamine transport (GO:0015872)2.57392681
148DNA demethylation (GO:0080111)2.57105496
149negative regulation of mast cell activation (GO:0033004)2.55495706
150negative regulation of reactive oxygen species metabolic process (GO:2000378)2.54846296
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49235200
152otic vesicle formation (GO:0030916)2.48043243
153male meiosis I (GO:0007141)2.46537423
154regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43649006
155preassembly of GPI anchor in ER membrane (GO:0016254)2.42872271
156somite development (GO:0061053)2.42330462
157rhodopsin mediated signaling pathway (GO:0016056)2.42089868
158tryptophan metabolic process (GO:0006568)2.41982506
159retinal cone cell development (GO:0046549)2.40968738
160inner ear receptor stereocilium organization (GO:0060122)2.40776169
161negative regulation of telomere maintenance (GO:0032205)2.39841045
162action potential (GO:0001508)2.39173651
163actin-myosin filament sliding (GO:0033275)12.2006136
164muscle filament sliding (GO:0030049)12.2006136
165regulation of skeletal muscle contraction (GO:0014819)11.9654168
166skeletal muscle contraction (GO:0003009)10.4955193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.65084532
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.12229556
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.47982730
4VDR_22108803_ChIP-Seq_LS180_Human3.18206047
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.14933199
6EZH2_22144423_ChIP-Seq_EOC_Human3.10568690
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.06151615
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.04611292
9GBX2_23144817_ChIP-Seq_PC3_Human2.86272180
10IGF1R_20145208_ChIP-Seq_DFB_Human2.74587030
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.69465716
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.69465716
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68257450
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58211494
15ZNF263_19887448_ChIP-Seq_K562_Human2.57895844
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38229068
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37363432
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.35416750
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.35409672
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.28505179
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27187219
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.19043664
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09445669
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01631983
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.01421090
26ER_23166858_ChIP-Seq_MCF-7_Human1.99002886
27BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.98945535
28FUS_26573619_Chip-Seq_HEK293_Human1.96188934
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95544877
30P300_19829295_ChIP-Seq_ESCs_Human1.92973677
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91427639
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88749921
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84304233
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79315173
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.78286781
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77104979
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74180648
38EWS_26573619_Chip-Seq_HEK293_Human1.73047669
39TAF15_26573619_Chip-Seq_HEK293_Human1.70510367
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.68814397
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68077174
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65978377
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64330725
44CTCF_21964334_ChIP-Seq_BJAB-B_Human1.57101595
45TP53_22573176_ChIP-Seq_HFKS_Human1.56009344
46SMAD4_21799915_ChIP-Seq_A2780_Human1.54961538
47MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.53386660
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53089534
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51239372
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50546442
51NANOG_19829295_ChIP-Seq_ESCs_Human1.50292064
52SOX2_19829295_ChIP-Seq_ESCs_Human1.50292064
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49970302
54BCAT_22108803_ChIP-Seq_LS180_Human1.49879041
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48788096
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47467202
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47361342
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45325957
59STAT3_23295773_ChIP-Seq_U87_Human1.44823032
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.44618548
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.42454368
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42007356
63TCF4_23295773_ChIP-Seq_U87_Human1.40592041
64AR_25329375_ChIP-Seq_VCAP_Human1.40141150
65* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39005468
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.38644974
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37792288
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36982615
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36789220
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35782451
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35549207
72STAT1_20625510_ChIP-Seq_HELA_Human1.35274866
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34822556
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34208920
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.33959467
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.33128601
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.32093551
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30658088
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.30279012
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.29959476
81KDM2B_26808549_Chip-Seq_DND41_Human1.29546158
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28656725
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.28303670
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26367642
85MAF_26560356_Chip-Seq_TH1_Human1.25704610
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.24581024
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23756652
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.21838961
89CTCF_27219007_Chip-Seq_Bcells_Human1.21444208
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21019003
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.20987562
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20478445
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.20478445
94OCT4_20526341_ChIP-Seq_ESCs_Human1.20207627
95TCF4_22108803_ChIP-Seq_LS180_Human1.20150584
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19315629
97TCF7_22412390_ChIP-Seq_EML_Mouse1.19289210
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18683342
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18683342
100SA1_27219007_Chip-Seq_Bcells_Human1.17516687
101REST_21632747_ChIP-Seq_MESCs_Mouse1.17389911
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16111921
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.16058838
104HOXB7_26014856_ChIP-Seq_BT474_Human1.15292090
105CTCF_21964334_Chip-Seq_Bcells_Human1.14739418
106NCOR_22424771_ChIP-Seq_293T_Human1.14258472
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.13812694
108AR_20517297_ChIP-Seq_VCAP_Human1.12809750
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12690117
110FOXH1_21741376_ChIP-Seq_ESCs_Human1.12527622
111GATA4_21415370_ChIP-Seq_HL-1_Mouse1.11378645
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11187311
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11050277
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10745047
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.08948116
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08198152
117SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08133312
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07903005
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.07739427
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07720576
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07418015
122KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06717072
123* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06629711
124IRF1_19129219_ChIP-ChIP_H3396_Human1.05527455
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05319107
126RUNX2_22187159_ChIP-Seq_PCA_Human1.04787017
127P53_22387025_ChIP-Seq_ESCs_Mouse1.04706531
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04484686
129AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04219401
130EGR1_19032775_ChIP-ChIP_M12_Human1.04110174
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04029699
132SPI1_20517297_ChIP-Seq_HL60_Human1.03824576
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03134768
134RNF2_27304074_Chip-Seq_NSC_Mouse1.03004797
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02926960
136AR_21572438_ChIP-Seq_LNCaP_Human1.02903818
137PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02240437
138EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01343351
139NANOG_18555785_Chip-Seq_ESCs_Mouse1.00306180
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00199740
141SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00142741
142BCL6_27268052_Chip-Seq_Bcells_Human0.99585207
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99463266
144CDX2_22108803_ChIP-Seq_LS180_Human0.99338560
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99039931
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98819242
147RACK7_27058665_Chip-Seq_MCF-7_Human0.98568769
148VDR_24787735_ChIP-Seq_THP-1_Human0.97871571
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97718789
150LXR_22292898_ChIP-Seq_THP-1_Human0.97682231
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97586112
152MYC_18940864_ChIP-ChIP_HL60_Human0.96514899
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.96422927
154CJUN_26792858_Chip-Seq_BT549_Human0.96257439
155* MYC_19829295_ChIP-Seq_ESCs_Human0.96220303
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.94597859
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94451025
158* CTCF_26484167_Chip-Seq_Bcells_Mouse0.94162807
159NANOG_20526341_ChIP-Seq_ESCs_Human0.93593968
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91327674
161CBP_20019798_ChIP-Seq_JUKART_Human0.90955288
162IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90955288
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89220278
164SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88978307
165ELF1_20517297_ChIP-Seq_JURKAT_Human0.88944234
166CEBPB_22108803_ChIP-Seq_LS180_Human0.88814053
167ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88741509
168ELK3_25401928_ChIP-Seq_HUVEC_Human0.88246208
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.87007010
170* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86632973
171STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86484401
172BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86157301
173JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85970181
174GATA6_21074721_ChIP-Seq_CACO-2_Human0.85014776
175TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84226149
176SPI1_23127762_ChIP-Seq_K562_Human0.83895146
177ATF3_27146783_Chip-Seq_COLON_Human0.83817970
178NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83616322
179NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83616322
180* RAC3_21632823_ChIP-Seq_H3396_Human0.83154115
181UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82509799
182CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81893579
183MAF_26560356_Chip-Seq_TH2_Human0.81755974
184GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81670461
185BCOR_27268052_Chip-Seq_Bcells_Human0.80405878
186ZNF274_21170338_ChIP-Seq_K562_Hela0.79665001
187KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79166682
188* TP63_22573176_ChIP-Seq_HFKS_Human0.78970523
189P68_20966046_ChIP-Seq_HELA_Human0.78803526
190STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.77898046
191ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77840080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.05742645
2MP0003646_muscle_fatigue6.94745071
3MP0000749_muscle_degeneration6.16793247
4MP0000751_myopathy5.63977402
5MP0000747_muscle_weakness4.27463166
6MP0002106_abnormal_muscle_physiology4.14726665
7MP0004036_abnormal_muscle_relaxation4.08341755
8MP0002837_dystrophic_cardiac_calcinosis3.72426253
9MP0000759_abnormal_skeletal_muscle3.62640767
10MP0004087_abnormal_muscle_fiber3.41020296
11MP0002269_muscular_atrophy3.37453927
12MP0005369_muscle_phenotype3.36730567
13MP0004130_abnormal_muscle_cell3.21754747
14MP0000750_abnormal_muscle_regeneration3.16905894
15MP0005620_abnormal_muscle_contractility3.06352681
16MP0000733_abnormal_muscle_development2.38397648
17MP0004233_abnormal_muscle_weight2.27582285
18MP0002332_abnormal_exercise_endurance2.23042495
19MP0003195_calcinosis2.18465121
20MP0005330_cardiomyopathy2.12349071
21MP0004084_abnormal_cardiac_muscle2.11792844
22MP0008877_abnormal_DNA_methylation2.11336237
23MP0002876_abnormal_thyroid_physiology2.03676946
24MP0005551_abnormal_eye_electrophysiolog2.01670751
25MP0002102_abnormal_ear_morphology2.00942182
26MP0000569_abnormal_digit_pigmentation1.92374535
27MP0004142_abnormal_muscle_tone1.82704057
28MP0005645_abnormal_hypothalamus_physiol1.76843930
29MP0006036_abnormal_mitochondrial_physio1.74401105
30MP0002638_abnormal_pupillary_reflex1.73729936
31MP0004185_abnormal_adipocyte_glucose1.72968920
32MP0002108_abnormal_muscle_morphology1.70870008
33MP0006072_abnormal_retinal_apoptosis1.62894647
34MP0005253_abnormal_eye_physiology1.58216849
35MP0004215_abnormal_myocardial_fiber1.52392190
36MP0002972_abnormal_cardiac_muscle1.50020533
37MP0005666_abnormal_adipose_tissue1.47561206
38MP0008872_abnormal_physiological_respon1.47127829
39MP0004510_myositis1.44260076
40MP0006276_abnormal_autonomic_nervous1.44198084
41MP0004484_altered_response_of1.41959276
42MP0006292_abnormal_olfactory_placode1.39792273
43MP0009046_muscle_twitch1.38194289
44MP0010630_abnormal_cardiac_muscle1.37791524
45MP0001968_abnormal_touch/_nociception1.36179355
46MP0002971_abnormal_brown_adipose1.32640062
47MP0001501_abnormal_sleep_pattern1.32504222
48MP0005167_abnormal_blood-brain_barrier1.30422193
49MP0002272_abnormal_nervous_system1.27085329
50MP0009745_abnormal_behavioral_response1.25874198
51MP0003011_delayed_dark_adaptation1.25752253
52MP0003221_abnormal_cardiomyocyte_apopto1.25140497
53MP0003880_abnormal_central_pattern1.22416714
54MP0004885_abnormal_endolymph1.17609150
55MP0005385_cardiovascular_system_phenoty1.17159733
56MP0001544_abnormal_cardiovascular_syste1.17159733
57MP0005646_abnormal_pituitary_gland1.16188765
58MP0008875_abnormal_xenobiotic_pharmacok1.13117970
59MP0000427_abnormal_hair_cycle1.11911969
60MP0001986_abnormal_taste_sensitivity1.09901396
61MP0003136_yellow_coat_color1.09672714
62MP0003950_abnormal_plasma_membrane1.07536909
63MP0002736_abnormal_nociception_after1.04327807
64MP0003787_abnormal_imprinting1.03441988
65MP0001486_abnormal_startle_reflex0.99469404
66MP0005375_adipose_tissue_phenotype0.99446097
67MP0001984_abnormal_olfaction0.98179982
68MP0004742_abnormal_vestibular_system0.96892743
69MP0005266_abnormal_metabolism0.96770052
70MP0002734_abnormal_mechanical_nocicepti0.93574074
71MP0001853_heart_inflammation0.91911084
72MP0001835_abnormal_antigen_presentation0.90242125
73MP0001485_abnormal_pinna_reflex0.89676355
74MP0000230_abnormal_systemic_arterial0.89637487
75MP0004085_abnormal_heartbeat0.89047551
76MP0000631_abnormal_neuroendocrine_gland0.88906390
77MP0002234_abnormal_pharynx_morphology0.88107002
78MP0002163_abnormal_gland_morphology0.87291279
79MP0003137_abnormal_impulse_conducting0.86748793
80MP0005174_abnormal_tail_pigmentation0.86176282
81MP0002277_abnormal_respiratory_mucosa0.85963860
82MP0002733_abnormal_thermal_nociception0.84934108
83MP0001529_abnormal_vocalization0.84667445
84MP0008775_abnormal_heart_ventricle0.84151744
85MP0004924_abnormal_behavior0.83910105
86MP0005386_behavior/neurological_phenoty0.83910105
87MP0005084_abnormal_gallbladder_morpholo0.83687720
88MP0002067_abnormal_sensory_capabilities0.83184666
89MP0002064_seizures0.82765343
90MP0003705_abnormal_hypodermis_morpholog0.81986945
91MP0001970_abnormal_pain_threshold0.81728932
92MP0002653_abnormal_ependyma_morphology0.81604877
93MP0000685_abnormal_immune_system0.81340468
94MP0002254_reproductive_system_inflammat0.80440089
95MP0002938_white_spotting0.79848096
96MP0000343_altered_response_to0.79721794
97MP0004270_analgesia0.79706670
98MP0002572_abnormal_emotion/affect_behav0.78030760
99MP0005332_abnormal_amino_acid0.76662452
100MP0002160_abnormal_reproductive_system0.75718867
101MP0002822_catalepsy0.74814265
102MP0002735_abnormal_chemical_nociception0.74147313
103MP0003806_abnormal_nucleotide_metabolis0.73777661
104MP0006035_abnormal_mitochondrial_morpho0.73767945
105MP0005410_abnormal_fertilization0.73604412
106MP0000372_irregular_coat_pigmentation0.71843984
107MP0003656_abnormal_erythrocyte_physiolo0.71592480
108MP0005451_abnormal_body_composition0.71327819
109MP0005423_abnormal_somatic_nervous0.70593204
110MP0002095_abnormal_skin_pigmentation0.70262397
111MP0001346_abnormal_lacrimal_gland0.70249068
112MP0002557_abnormal_social/conspecific_i0.70242979
113MP0008995_early_reproductive_senescence0.70008227
114MP0004134_abnormal_chest_morphology0.68928725
115MP0001502_abnormal_circadian_rhythm0.68664320
116MP0005389_reproductive_system_phenotype0.67165257
117MP0002229_neurodegeneration0.66679195
118MP0003828_pulmonary_edema0.66388275
119MP0008961_abnormal_basal_metabolism0.65588625
120MP0001790_abnormal_immune_system0.63686680
121MP0005387_immune_system_phenotype0.63686680
122MP0002138_abnormal_hepatobiliary_system0.63512675
123MP0002148_abnormal_hypersensitivity_rea0.61060502
124MP0000013_abnormal_adipose_tissue0.59842584
125MP0005334_abnormal_fat_pad0.59321658
126MP0006138_congestive_heart_failure0.56997813
127MP0005275_abnormal_skin_tensile0.55876285
128MP0003045_fibrosis0.55613537
129MP0000266_abnormal_heart_morphology0.55043967
130MP0001299_abnormal_eye_distance/0.54923214
131MP0000762_abnormal_tongue_morphology0.54176284
132MP0002078_abnormal_glucose_homeostasis0.54117943
133MP0002127_abnormal_cardiovascular_syste0.53669322
134MP0003436_decreased_susceptibility_to0.50483584
135MP0000579_abnormal_nail_morphology0.48516828
136MP0005670_abnormal_white_adipose0.47971100
137MP0004043_abnormal_pH_regulation0.45649298
138MP0009115_abnormal_fat_cell0.44104591
139MP0005584_abnormal_enzyme/coenzyme_acti0.42279818
140MP0009250_abnormal_appendicular_skeleto0.40454089
141MP0005319_abnormal_enzyme/_coenzyme0.39721948
142MP0000003_abnormal_adipose_tissue0.37829168
143MP0002796_impaired_skin_barrier0.34796816
144MP0001348_abnormal_lacrimal_gland0.34318294
145MP0005166_decreased_susceptibility_to0.32792799
146MP0005452_abnormal_adipose_tissue0.31676320
147MP0001800_abnormal_humoral_immune0.31567860
148MP0003959_abnormal_lean_body0.31492495
149MP0005083_abnormal_biliary_tract0.30511188
150MP0000383_abnormal_hair_follicle0.29818342
151MP0002896_abnormal_bone_mineralization0.29534688
152MP0009785_altered_susceptibility_to0.28845942
153MP0003948_abnormal_gas_homeostasis0.28635996
154MP0005000_abnormal_immune_tolerance0.28264511
155MP0005535_abnormal_body_temperature0.27929080
156MP0001849_ear_inflammation0.27751132
157MP0004947_skin_inflammation0.26794813
158MP0003567_abnormal_fetal_cardiomyocyte0.24257314
159MP0003191_abnormal_cellular_cholesterol0.23280643
160MP0002128_abnormal_blood_circulation0.23087450
161MP0002723_abnormal_immune_serum0.22985426
162MP0008569_lethality_at_weaning0.22894045
163MP0004147_increased_porphyrin_level0.22557712
164MP0003566_abnormal_cell_adhesion0.22482966

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.58437814
2Nemaline bodies (HP:0003798)8.96890397
3Exercise-induced myalgia (HP:0003738)8.88666914
4Exercise-induced muscle cramps (HP:0003710)8.16164094
5Type 1 muscle fiber predominance (HP:0003803)7.36720282
6Distal arthrogryposis (HP:0005684)7.10551801
7Muscle hypertrophy of the lower extremities (HP:0008968)7.08015021
8Myopathic facies (HP:0002058)6.59555196
9Calf muscle hypertrophy (HP:0008981)6.35499276
10Round ear (HP:0100830)5.66691252
11Ulnar deviation of the wrist (HP:0003049)5.65138406
12Difficulty running (HP:0009046)5.53483176
13Muscle fiber splitting (HP:0003555)5.44804326
14Myoglobinuria (HP:0002913)5.31192374
15Hyporeflexia of lower limbs (HP:0002600)4.88942959
16Muscle stiffness (HP:0003552)4.82961639
17Calcaneovalgus deformity (HP:0001848)4.79941058
18EMG: myopathic abnormalities (HP:0003458)4.65445675
19Absent phalangeal crease (HP:0006109)4.53698565
20Rhabdomyolysis (HP:0003201)4.50973825
21Increased connective tissue (HP:0009025)4.42868862
22Deformed tarsal bones (HP:0008119)4.29273110
23Abnormality of the calf musculature (HP:0001430)4.27333563
24Myotonia (HP:0002486)4.14302510
25Abnormality of skeletal muscle fiber size (HP:0012084)3.78966950
26Abnormal finger flexion creases (HP:0006143)3.78342552
27Subaortic stenosis (HP:0001682)3.73810020
28Abnormality of the left ventricular outflow tract (HP:0011103)3.73810020
29Malignant hyperthermia (HP:0002047)3.57649596
30Frequent falls (HP:0002359)3.57631219
31Neck muscle weakness (HP:0000467)3.53512741
32Rimmed vacuoles (HP:0003805)3.47600921
33Difficulty climbing stairs (HP:0003551)3.42841778
34Congenital stationary night blindness (HP:0007642)3.34670397
35Increased variability in muscle fiber diameter (HP:0003557)3.33864010
36Areflexia of lower limbs (HP:0002522)3.19012990
37Pelvic girdle muscle weakness (HP:0003749)3.13539574
38Asymmetric septal hypertrophy (HP:0001670)3.04287772
39Abnormality of the musculature of the pelvis (HP:0001469)3.01622664
40Abnormality of the hip-girdle musculature (HP:0001445)3.01622664
41Shoulder girdle muscle weakness (HP:0003547)3.00725977
42Hyperkalemia (HP:0002153)2.98356991
43Pancreatic cysts (HP:0001737)2.93459220
44Sudden death (HP:0001699)2.92186600
45Abnormality of midbrain morphology (HP:0002418)2.90513369
46Molar tooth sign on MRI (HP:0002419)2.90513369
47Abnormality of the calcaneus (HP:0008364)2.90427686
48Paralysis (HP:0003470)2.70842348
49Nephronophthisis (HP:0000090)2.67878328
50Distal lower limb muscle weakness (HP:0009053)2.67658468
51Abnormality of the renal cortex (HP:0011035)2.65761839
52Abnormality of the neuromuscular junction (HP:0003398)2.60803017
53Fatigable weakness (HP:0003473)2.60803017
54Type II lissencephaly (HP:0007260)2.59833480
55Pancreatic fibrosis (HP:0100732)2.56180300
56Acute necrotizing encephalopathy (HP:0006965)2.53706649
57True hermaphroditism (HP:0010459)2.51443101
58Slender build (HP:0001533)2.44570567
59Hypoplastic ischia (HP:0003175)2.39144466
60Mitochondrial inheritance (HP:0001427)2.37138308
61EMG: neuropathic changes (HP:0003445)2.36072092
62Muscular dystrophy (HP:0003560)2.34320379
63Abnormality of the renal medulla (HP:0100957)2.31455310
64Hepatocellular necrosis (HP:0001404)2.31376222
65Facial diplegia (HP:0001349)2.30760337
66Increased CSF lactate (HP:0002490)2.30121145
67Proximal amyotrophy (HP:0007126)2.28942999
68Acute encephalopathy (HP:0006846)2.27721518
69Mildly elevated creatine phosphokinase (HP:0008180)2.26866409
70Progressive macrocephaly (HP:0004481)2.26394595
71Hepatic necrosis (HP:0002605)2.25532487
72Abnormality of alanine metabolism (HP:0010916)2.25446112
73Hyperalaninemia (HP:0003348)2.25446112
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25446112
75Generalized muscle weakness (HP:0003324)2.23577369
76Broad-based gait (HP:0002136)2.22843015
77Distal lower limb amyotrophy (HP:0008944)2.22429783
78Attenuation of retinal blood vessels (HP:0007843)2.21876437
79Ventricular tachycardia (HP:0004756)2.21543224
80Abnormal mitochondria in muscle tissue (HP:0008316)2.21469838
81Ketoacidosis (HP:0001993)2.18668926
82Abnormal rod and cone electroretinograms (HP:0008323)2.17632134
83Limb-girdle muscle weakness (HP:0003325)2.15650571
84Methylmalonic acidemia (HP:0002912)2.15604721
85Scapular winging (HP:0003691)2.15217109
86Medial flaring of the eyebrow (HP:0010747)2.14990001
87Progressive muscle weakness (HP:0003323)2.13400020
88Hyperventilation (HP:0002883)2.12163724
89Abnormal drinking behavior (HP:0030082)2.11552191
90Polydipsia (HP:0001959)2.11552191
91Large for gestational age (HP:0001520)2.11275708
92Centrally nucleated skeletal muscle fibers (HP:0003687)2.10428102
93Bulbar palsy (HP:0001283)2.09564665
94Abnormality of the shoulder girdle musculature (HP:0001435)2.07522314
95Hyperglycinuria (HP:0003108)2.06747414
96Abnormality of the ischium (HP:0003174)2.06675373
97Hypothermia (HP:0002045)2.04195223
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03383708
99Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02694606
100Tubular atrophy (HP:0000092)2.02572110
101Inability to walk (HP:0002540)2.02441687
102Nonprogressive disorder (HP:0003680)2.02291692
103Gowers sign (HP:0003391)2.01991695
104Weak cry (HP:0001612)2.00913937
105Muscle fiber inclusion bodies (HP:0100299)10.1591392
106Abolished electroretinogram (ERG) (HP:0000550)1.99721853
107Febrile seizures (HP:0002373)1.98522644
108Spinal rigidity (HP:0003306)1.97514755
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95011951
110Limb-girdle muscle atrophy (HP:0003797)1.93669506
111Ketosis (HP:0001946)1.93112372
112Type 2 muscle fiber atrophy (HP:0003554)1.92264527
113Methylmalonic aciduria (HP:0012120)1.88597619
114Renal cortical cysts (HP:0000803)1.88411539
115Gaze-evoked nystagmus (HP:0000640)1.86469976
116Decreased central vision (HP:0007663)1.85905956
117Pendular nystagmus (HP:0012043)1.85166193
118Waddling gait (HP:0002515)1.84609731
119Optic disc pallor (HP:0000543)1.84385100
120Ulnar deviation of finger (HP:0009465)1.82868647
121Lipid accumulation in hepatocytes (HP:0006561)1.78708800
122Lissencephaly (HP:0001339)1.78597455
123Lipoatrophy (HP:0100578)1.78596938
124Increased corneal curvature (HP:0100692)1.77597634
125Keratoconus (HP:0000563)1.77597634
126Progressive inability to walk (HP:0002505)1.74485184
127Hip contracture (HP:0003273)1.73236703
128Absent/shortened dynein arms (HP:0200106)1.73126337
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.73126337
130Cerebellar dysplasia (HP:0007033)1.73019245
131Hemiparesis (HP:0001269)1.72781741
132Lactic acidosis (HP:0003128)1.70536612
133Metatarsus adductus (HP:0001840)1.70410499
134Dilated cardiomyopathy (HP:0001644)1.69878030
135Achilles tendon contracture (HP:0001771)1.69384996
136Polyuria (HP:0000103)1.69228327
137Chronic hepatic failure (HP:0100626)1.67910187
138Severe muscular hypotonia (HP:0006829)1.67835718
139Lower limb amyotrophy (HP:0007210)1.65175560
140Fetal akinesia sequence (HP:0001989)1.61668023
141Hyperuricemia (HP:0002149)1.57490607
142Increased purine levels (HP:0004368)1.57490607
143Increased density of long bones (HP:0006392)1.56246714
144Stridor (HP:0010307)1.56196022
145Cholelithiasis (HP:0001081)1.52184208
146Abnormality of the Achilles tendon (HP:0005109)1.51481060
147Exercise intolerance (HP:0003546)1.50648284
148Abnormality of potassium homeostasis (HP:0011042)1.48036647
149Short palpebral fissure (HP:0012745)1.47983816
150Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.47018305
151Tarsal synostosis (HP:0008368)1.42870681
152Bundle branch block (HP:0011710)1.41420520
153Long clavicles (HP:0000890)1.40480856
154Foot dorsiflexor weakness (HP:0009027)1.40311444
155Respiratory insufficiency due to muscle weakness (HP:0002747)1.38227444
156Hyperphosphatemia (HP:0002905)1.37814531
157Gout (HP:0001997)1.34869782
158Congenital hip dislocation (HP:0001374)1.32606363
159Abnormality of the foot musculature (HP:0001436)1.32384419
160Abnormal gallbladder morphology (HP:0012437)1.31109310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.79108840
2TTN6.62226098
3PHKG15.24372137
4PHKG25.24372137
5FRK4.65793319
6PIK3CG4.25027735
7NME13.91852171
8MAP2K32.69749872
9ADRBK22.61103586
10WNK32.10749355
11MAP4K22.06304137
12TAOK32.03125838
13MAP3K72.02585104
14DMPK2.00789088
15NUAK11.96041681
16MAPK131.95519453
17NEK11.94658972
18BMPR1B1.90891916
19GRK11.83950829
20PINK11.81227536
21PDK31.75953854
22PDK41.75953854
23WNK41.66942198
24MAPK121.54555735
25ACVR1B1.52706895
26TLK11.50870204
27CASK1.50862161
28PDK21.41538801
29PIK3CA1.40550320
30MARK11.35440776
31TRIB31.33855910
32OXSR11.32554218
33DAPK21.30437612
34MAP2K61.24481468
35BCKDK1.22520311
36STK391.21343779
37MAP2K41.21019164
38TRIM281.11285974
39MUSK1.10962376
40TNIK1.06141071
41PKN21.04166133
42MAP3K31.02751361
43PRKAA20.98631212
44NEK90.98482765
45STK160.96228027
46ADRBK10.94452087
47MAP3K40.93370919
48TXK0.88298215
49TRPM70.87652005
50ZAK0.86988094
51MAP3K140.86191009
52PAK30.85818256
53CCNB10.83470651
54PTK2B0.82881305
55TYK20.81716301
56DYRK20.78601692
57MAPKAPK30.76761676
58MAP3K110.76553275
59ERBB30.76523894
60PRKAA10.76505670
61EPHB10.75285810
62STK240.72743941
63PRKCE0.72190761
64CAMK2A0.68617671
65MAPK110.68422489
66PLK20.67665489
67TBK10.66503408
68CAMKK20.63424185
69MKNK20.61571616
70CAMK10.60793846
71PRKCQ0.60151800
72TAOK20.55713855
73AKT20.54644804
74STK38L0.54455915
75VRK10.53991351
76RIPK10.53437070
77NLK0.52114165
78CAMK40.50070610
79PRKCG0.49859638
80FLT30.49218355
81TEC0.48046672
82CAMK2D0.47737508
83MAP2K70.47513138
84JAK10.47184456
85IKBKB0.46219684
86CSNK1G10.45390342
87TGFBR20.44908116
88TNK20.44738603
89MAP3K50.44488901
90IKBKE0.43931392
91PNCK0.43861887
92CAMK2G0.42209816
93EIF2AK30.40906410
94MST40.40271574
95STK110.40149368
96LIMK10.39103863
97JAK30.38914369
98TGFBR10.38234982
99MAPKAPK50.37586223
100RPS6KA40.37328414
101PKN10.37149287
102MAP3K130.34534856
103BCR0.34402154
104MAP3K10.34286944
105PTK60.34020116
106SGK10.33724629
107CSNK1G20.33431773
108TAOK10.33240787
109RPS6KA50.32387238
110MAP3K100.31854985
111CAMK1D0.31255298
112GRK70.31246657
113IRAK10.30675132
114CSNK1A10.30324516
115PRKCI0.29967598
116MARK30.29288109
117CSNK1G30.29116832
118PRKCA0.28145949
119PLK40.27860449
120CAMK2B0.27736756
121CDK190.27516831
122BRSK20.27268675
123MAP2K20.27045589
124JAK20.25533294
125FGFR40.22900694
126FGFR30.21801325
127SIK10.21712015
128ILK0.21619436
129BMX0.20546668
130RIPK40.20134593
131PRKG10.19929917
132IRAK30.18854138
133PRKD10.18829972
134CHUK0.17575217
135PRKACB0.16731794
136ERN10.16708023
137PDK10.16204883
138RPS6KA30.15944360
139RPS6KA10.15794538
140MAPK40.14642667
141MAPK70.13915154
142PRKACA0.13750248
143DYRK1B0.13703379
144EPHA30.12288336
145PDPK10.12246840
146HCK0.11788888
147EEF2K0.11617084
148TIE10.11132138
149ROCK10.10536490
150SYK0.09884076
151MAP3K60.09089938
152INSRR0.07531737
153RPS6KB20.07352909
154KSR20.07291774
155MAPKAPK20.07225307
156KIT0.06931617
157RPS6KA60.06844508
158MAP4K10.06695323
159CSF1R0.06369823
160MOS0.06216630
161MAP2K10.06109588
162CSK0.05579499
163PRKACG0.03978107
164LRRK20.03400427
165MST1R0.01748106
166BLK0.01533369
167LATS20.01498111

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.18478833
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.17003124
3Cardiac muscle contraction_Homo sapiens_hsa042603.48957999
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.44270681
5Dilated cardiomyopathy_Homo sapiens_hsa054143.37255625
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.17468481
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82927110
8Starch and sucrose metabolism_Homo sapiens_hsa005002.82292659
9Phototransduction_Homo sapiens_hsa047442.75016006
10Nitrogen metabolism_Homo sapiens_hsa009102.73927417
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.57747783
12Butanoate metabolism_Homo sapiens_hsa006502.27618572
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21529245
14Insulin resistance_Homo sapiens_hsa049312.20445865
15Glucagon signaling pathway_Homo sapiens_hsa049222.11745303
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09824248
17Propanoate metabolism_Homo sapiens_hsa006402.06140332
18Insulin signaling pathway_Homo sapiens_hsa049102.02778080
19Viral myocarditis_Homo sapiens_hsa054162.01492736
20Carbon metabolism_Homo sapiens_hsa012001.98629810
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.97012846
22Oxytocin signaling pathway_Homo sapiens_hsa049211.89480565
23Circadian rhythm_Homo sapiens_hsa047101.81116538
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80227529
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67268735
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.66704878
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65401899
28Parkinsons disease_Homo sapiens_hsa050121.64931036
29Alzheimers disease_Homo sapiens_hsa050101.63040936
30Tryptophan metabolism_Homo sapiens_hsa003801.62468747
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56064846
32Ether lipid metabolism_Homo sapiens_hsa005651.56038110
33Nicotine addiction_Homo sapiens_hsa050331.55443104
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.54359506
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45595631
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45129787
37Galactose metabolism_Homo sapiens_hsa000521.45047570
38Calcium signaling pathway_Homo sapiens_hsa040201.41378235
39Oxidative phosphorylation_Homo sapiens_hsa001901.41339849
40Selenocompound metabolism_Homo sapiens_hsa004501.40783444
41AMPK signaling pathway_Homo sapiens_hsa041521.39705330
42Homologous recombination_Homo sapiens_hsa034401.38606280
43Fatty acid degradation_Homo sapiens_hsa000711.37016503
44Olfactory transduction_Homo sapiens_hsa047401.34606793
45Protein export_Homo sapiens_hsa030601.33576548
46Insulin secretion_Homo sapiens_hsa049111.27758358
47Fanconi anemia pathway_Homo sapiens_hsa034601.26979064
48Fructose and mannose metabolism_Homo sapiens_hsa000511.23841024
49Peroxisome_Homo sapiens_hsa041461.20924978
50Basal transcription factors_Homo sapiens_hsa030221.17681341
51Leishmaniasis_Homo sapiens_hsa051401.11840758
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11837648
53Biosynthesis of amino acids_Homo sapiens_hsa012301.10260467
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05701550
55Tight junction_Homo sapiens_hsa045301.04893225
56Circadian entrainment_Homo sapiens_hsa047131.02492481
57RNA degradation_Homo sapiens_hsa030181.02395952
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00616724
59Pyruvate metabolism_Homo sapiens_hsa006201.00007241
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99314797
61Caffeine metabolism_Homo sapiens_hsa002320.97480550
62RNA polymerase_Homo sapiens_hsa030200.97409841
63Pentose phosphate pathway_Homo sapiens_hsa000300.95977842
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.95964346
65Arginine and proline metabolism_Homo sapiens_hsa003300.95716827
66Regulation of autophagy_Homo sapiens_hsa041400.95188486
67Taste transduction_Homo sapiens_hsa047420.94850096
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92289981
69Focal adhesion_Homo sapiens_hsa045100.89183023
70FoxO signaling pathway_Homo sapiens_hsa040680.88944391
71Arachidonic acid metabolism_Homo sapiens_hsa005900.88828030
72HIF-1 signaling pathway_Homo sapiens_hsa040660.87397026
73ABC transporters_Homo sapiens_hsa020100.87134964
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86985614
75Morphine addiction_Homo sapiens_hsa050320.85607136
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.84804978
77Osteoclast differentiation_Homo sapiens_hsa043800.84676704
78Histidine metabolism_Homo sapiens_hsa003400.84152639
79Chemical carcinogenesis_Homo sapiens_hsa052040.82888998
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82736661
81GnRH signaling pathway_Homo sapiens_hsa049120.81297141
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80597730
83Salivary secretion_Homo sapiens_hsa049700.80004833
84Ovarian steroidogenesis_Homo sapiens_hsa049130.79712201
85Fatty acid metabolism_Homo sapiens_hsa012120.79284173
86B cell receptor signaling pathway_Homo sapiens_hsa046620.77759990
87Purine metabolism_Homo sapiens_hsa002300.76148429
88Legionellosis_Homo sapiens_hsa051340.75207861
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74787543
90Retinol metabolism_Homo sapiens_hsa008300.73732752
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.73135657
92VEGF signaling pathway_Homo sapiens_hsa043700.72310198
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71764023
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71051846
95Sulfur metabolism_Homo sapiens_hsa009200.70646637
96Serotonergic synapse_Homo sapiens_hsa047260.70446558
97Toxoplasmosis_Homo sapiens_hsa051450.70262588
98MAPK signaling pathway_Homo sapiens_hsa040100.70206993
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69325984
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.68855178
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67914147
102GABAergic synapse_Homo sapiens_hsa047270.67182560
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.66362621
104Huntingtons disease_Homo sapiens_hsa050160.65058078
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64489631
106TNF signaling pathway_Homo sapiens_hsa046680.64233408
107Metabolic pathways_Homo sapiens_hsa011000.63897771
108Platelet activation_Homo sapiens_hsa046110.63471162
109One carbon pool by folate_Homo sapiens_hsa006700.63039984
110Type II diabetes mellitus_Homo sapiens_hsa049300.59729161
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59537805
112Gastric acid secretion_Homo sapiens_hsa049710.59445774
113Glutamatergic synapse_Homo sapiens_hsa047240.56886046
114mTOR signaling pathway_Homo sapiens_hsa041500.55881866
115Amoebiasis_Homo sapiens_hsa051460.55858918
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55799941
117Tuberculosis_Homo sapiens_hsa051520.55666305
118Asthma_Homo sapiens_hsa053100.55328835
119Influenza A_Homo sapiens_hsa051640.54203018
120Graft-versus-host disease_Homo sapiens_hsa053320.54165965
121Arginine biosynthesis_Homo sapiens_hsa002200.53994284
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52750669
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.52496169
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51814250
125Allograft rejection_Homo sapiens_hsa053300.50772146
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49514078
127Fatty acid biosynthesis_Homo sapiens_hsa000610.49410676
128Fat digestion and absorption_Homo sapiens_hsa049750.49165268
129Salmonella infection_Homo sapiens_hsa051320.48805507
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.48712275
131Adherens junction_Homo sapiens_hsa045200.47339510
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.46491498
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46402039
134Renin secretion_Homo sapiens_hsa049240.46047978
135Primary immunodeficiency_Homo sapiens_hsa053400.45634700
136Long-term depression_Homo sapiens_hsa047300.44738528
137Sulfur relay system_Homo sapiens_hsa041220.44423465
138Pertussis_Homo sapiens_hsa051330.43397075
139Type I diabetes mellitus_Homo sapiens_hsa049400.43216951
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42529205
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42450855
142Glycerolipid metabolism_Homo sapiens_hsa005610.41231711
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.40191019
144Mineral absorption_Homo sapiens_hsa049780.39939458
145Dopaminergic synapse_Homo sapiens_hsa047280.39648775
146Prolactin signaling pathway_Homo sapiens_hsa049170.39524847
147Dorso-ventral axis formation_Homo sapiens_hsa043200.38811385
148cAMP signaling pathway_Homo sapiens_hsa040240.36490315
149Proteoglycans in cancer_Homo sapiens_hsa052050.34806160
150Measles_Homo sapiens_hsa051620.34613902
151PPAR signaling pathway_Homo sapiens_hsa033200.33671312
152Apoptosis_Homo sapiens_hsa042100.33463345
153Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32409461
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28417846
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26096442
156Acute myeloid leukemia_Homo sapiens_hsa052210.25295861
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22839529
158beta-Alanine metabolism_Homo sapiens_hsa004100.22699398
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21773780
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.20750015
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20617533
162Linoleic acid metabolism_Homo sapiens_hsa005910.19762846
163Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19481772
164Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17463588
165Autoimmune thyroid disease_Homo sapiens_hsa053200.17380367

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