KCNAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.86950490
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.38776613
3locomotory exploration behavior (GO:0035641)6.05165592
4positive regulation of gamma-delta T cell activation (GO:0046645)5.91365479
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.73197040
6synaptic vesicle exocytosis (GO:0016079)5.54251161
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52119743
8glutamate secretion (GO:0014047)5.51578067
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.36817544
10regulation of synaptic vesicle exocytosis (GO:2000300)5.21038770
11neuronal action potential propagation (GO:0019227)5.02583486
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98577824
13vocalization behavior (GO:0071625)4.89045407
14regulation of glutamate receptor signaling pathway (GO:1900449)4.85923119
15regulation of neuronal synaptic plasticity (GO:0048168)4.83672313
16regulation of synaptic vesicle transport (GO:1902803)4.73234088
17negative regulation of erythrocyte differentiation (GO:0045647)4.69141566
18sodium ion export (GO:0071436)4.62054760
19exploration behavior (GO:0035640)4.56689692
20neurotransmitter secretion (GO:0007269)4.50821366
21cellular potassium ion homeostasis (GO:0030007)4.49657835
22regulation of synapse structural plasticity (GO:0051823)4.46833536
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.45933161
24regulation of B cell receptor signaling pathway (GO:0050855)4.44796488
25protein localization to synapse (GO:0035418)4.43182178
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.39562688
27antigen processing and presentation of endogenous antigen (GO:0019883)4.31827513
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28367440
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.27176159
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25930220
31regulation of gamma-delta T cell activation (GO:0046643)4.19123703
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.16715465
33proline transport (GO:0015824)4.15994741
34positive thymic T cell selection (GO:0045059)4.13333193
35regulation of gamma-delta T cell differentiation (GO:0045586)4.02313331
36response to peptidoglycan (GO:0032494)4.02191667
37neutrophil activation involved in immune response (GO:0002283)3.99381007
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96661184
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95939324
40negative thymic T cell selection (GO:0045060)3.95339813
41long-term memory (GO:0007616)3.93644800
42G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.92458050
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90880027
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89731802
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.89731802
46modulation by symbiont of host immune response (GO:0052553)3.89731802
47positive regulation by symbiont of host defense response (GO:0052509)3.89731802
48modulation by symbiont of host defense response (GO:0052031)3.89731802
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89731802
50synaptic transmission, glutamatergic (GO:0035249)3.88107797
51regulation of ARF protein signal transduction (GO:0032012)3.87473180
52positive regulation of B cell differentiation (GO:0045579)3.86121355
53positive regulation of membrane potential (GO:0045838)3.83985146
54negative T cell selection (GO:0043383)3.83304568
55activation of protein kinase A activity (GO:0034199)3.81884602
56layer formation in cerebral cortex (GO:0021819)3.79204953
57leukocyte aggregation (GO:0070486)3.78346399
58regulation of synaptic plasticity (GO:0048167)3.77361465
59cellular extravasation (GO:0045123)3.77328284
60macrophage activation involved in immune response (GO:0002281)3.73018560
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.72913982
62B cell receptor signaling pathway (GO:0050853)3.71985791
63neuromuscular process controlling posture (GO:0050884)3.70862679
64neuromuscular process controlling balance (GO:0050885)3.68213060
65glutamate receptor signaling pathway (GO:0007215)3.62844492
66glycine transport (GO:0015816)3.62759570
67negative regulation of interleukin-12 production (GO:0032695)3.60834108
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.59609766
69detection of other organism (GO:0098543)3.58682637
70response to muramyl dipeptide (GO:0032495)3.58091969
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57178789
72neuron-neuron synaptic transmission (GO:0007270)3.56864850
73neurotransmitter transport (GO:0006836)3.56458922
74gamma-aminobutyric acid transport (GO:0015812)3.54181034
75detection of bacterium (GO:0016045)3.54155336
76L-amino acid import (GO:0043092)3.53686976
77regulation of mast cell degranulation (GO:0043304)3.52325175
78neurotransmitter-gated ion channel clustering (GO:0072578)3.51101904
79dendritic spine morphogenesis (GO:0060997)3.50685153
80regulation of leukocyte degranulation (GO:0043300)3.47993238
81positive T cell selection (GO:0043368)3.47789033
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.47589752
83thymic T cell selection (GO:0045061)3.47166162
84regulation of postsynaptic membrane potential (GO:0060078)3.46770518
85cerebellar Purkinje cell differentiation (GO:0021702)3.45809108
86T cell selection (GO:0045058)3.45023407
87membrane depolarization during action potential (GO:0086010)3.44593576
88T cell migration (GO:0072678)3.43645701
89regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43237112
90immunoglobulin mediated immune response (GO:0016064)3.42147392
91synaptic vesicle endocytosis (GO:0048488)3.39548445
92regulation of regulated secretory pathway (GO:1903305)3.39243446
93regulation of neurotransmitter secretion (GO:0046928)3.38959182
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38438626
95negative regulation of leukocyte mediated immunity (GO:0002704)3.37067774
96vesicle transport along microtubule (GO:0047496)3.37056547
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36615065
98regulation of dendritic spine morphogenesis (GO:0061001)3.36485201
99regulation of B cell differentiation (GO:0045577)3.35218033
100neuron cell-cell adhesion (GO:0007158)3.35145187
101regulation of neurotransmitter levels (GO:0001505)3.34541408
102negative regulation of lymphocyte mediated immunity (GO:0002707)3.33246325
103myeloid cell activation involved in immune response (GO:0002275)3.31278180
104long-term synaptic potentiation (GO:0060291)3.30117818
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29824500
106cell communication by electrical coupling (GO:0010644)3.28598136
107mannose metabolic process (GO:0006013)3.25499051
108negative regulation of T cell mediated immunity (GO:0002710)3.25350771
109response to interleukin-15 (GO:0070672)3.23216266
110positive regulation of neurotransmitter transport (GO:0051590)3.22118213
111cellular sodium ion homeostasis (GO:0006883)3.19322246
112positive regulation of Rap GTPase activity (GO:0032854)3.17494072
113regulation of vesicle fusion (GO:0031338)3.16119366
114regulation of mast cell activation involved in immune response (GO:0033006)3.15970245
115potassium ion import (GO:0010107)3.15928004
116membrane depolarization (GO:0051899)3.15735777
117positive regulation of mast cell activation (GO:0033005)3.14184826
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13970672
119regulation of neurotransmitter transport (GO:0051588)3.13660933
120chemosensory behavior (GO:0007635)3.13427468
121prepulse inhibition (GO:0060134)3.12011860
122positive regulation of synapse maturation (GO:0090129)3.10235488
123positive regulation of neurotransmitter secretion (GO:0001956)3.08363457
124transmission of nerve impulse (GO:0019226)3.08204141
125regulation of synaptic transmission, glutamatergic (GO:0051966)3.05192906
126regulation of clathrin-mediated endocytosis (GO:2000369)3.04197713
127germinal center formation (GO:0002467)3.01897464
128positive regulation of synaptic transmission (GO:0050806)3.01174215
129tolerance induction (GO:0002507)3.00452457
130regulation of synaptic transmission (GO:0050804)2.99971024
131axon cargo transport (GO:0008088)2.99884827
132positive regulation of fibroblast migration (GO:0010763)2.99369441
133innervation (GO:0060384)2.99297192
134neuronal ion channel clustering (GO:0045161)2.98287910
135respiratory burst (GO:0045730)2.97959851
136leukocyte degranulation (GO:0043299)2.97298815
137neuromuscular process (GO:0050905)2.96629969
138signal complex assembly (GO:0007172)2.96298196
139positive regulation of mast cell degranulation (GO:0043306)2.95967346
140positive regulation of mast cell activation involved in immune response (GO:0033008)2.95967346
141mast cell activation (GO:0045576)2.95867467
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95544717
143regulation of voltage-gated calcium channel activity (GO:1901385)2.95413659
144response to auditory stimulus (GO:0010996)2.93670367
145negative regulation of dendrite morphogenesis (GO:0050774)2.93235666
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91514919
147negative regulation of cell killing (GO:0031342)2.91514919
148membrane hyperpolarization (GO:0060081)2.91237241
149negative regulation of microtubule polymerization (GO:0031115)2.90221230
150cellular response to interleukin-15 (GO:0071350)2.89800290
151* synaptic transmission (GO:0007268)2.87480696
152negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85548358
153interferon-gamma-mediated signaling pathway (GO:0060333)2.84290590
154nerve growth factor signaling pathway (GO:0038180)2.84032123
155detection of external biotic stimulus (GO:0098581)2.82262432
156learning (GO:0007612)2.81889006
157potassium ion homeostasis (GO:0055075)2.81264902
158organelle transport along microtubule (GO:0072384)2.81037736
159dendritic spine organization (GO:0097061)2.80167962
160regulation of dendritic spine development (GO:0060998)2.79813860
161neutrophil activation (GO:0042119)2.79522654
162regulation of mast cell activation (GO:0033003)2.77638966
163Peyers patch development (GO:0048541)2.75447509
164mucosal-associated lymphoid tissue development (GO:0048537)2.75447509
165activated T cell proliferation (GO:0050798)2.73401441
166positive regulation of granulocyte differentiation (GO:0030854)2.73189749
167response to host immune response (GO:0052572)2.72912584
168response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72912584
169lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72833521
170positive regulation of regulated secretory pathway (GO:1903307)2.72232833
171granulocyte activation (GO:0036230)2.71886758
172regulation of T-helper 2 cell differentiation (GO:0045628)2.71397983
173regulation of interleukin-2 biosynthetic process (GO:0045076)2.70192717
174macrophage activation (GO:0042116)2.68284587
175regulation of Rap GTPase activity (GO:0032317)2.66373962
176regulation of T cell tolerance induction (GO:0002664)2.66246907
177negative regulation of toll-like receptor signaling pathway (GO:0034122)2.65595624
178defense response to protozoan (GO:0042832)2.64408571
179microglial cell activation (GO:0001774)2.63885143
180mast cell activation involved in immune response (GO:0002279)2.61018172
181mast cell degranulation (GO:0043303)2.61018172
182antigen processing and presentation via MHC class Ib (GO:0002475)2.60507798
183regulation of tolerance induction (GO:0002643)2.60384464
184response to protozoan (GO:0001562)2.59515880
185negative regulation of innate immune response (GO:0045824)2.57653799
186regulation of interferon-beta biosynthetic process (GO:0045357)2.57587105
187negative regulation of type 2 immune response (GO:0002829)2.57075862
188myeloid dendritic cell activation (GO:0001773)2.56568257
189positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.55558482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80516830
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.08002999
3* VDR_21846776_ChIP-Seq_THP-1_Human3.54279282
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.45240919
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.44667730
6MYC_22102868_ChIP-Seq_BL_Human3.08173293
7DROSHA_22980978_ChIP-Seq_HELA_Human3.03449688
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02057171
9* REST_21632747_ChIP-Seq_MESCs_Mouse3.01085400
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98781320
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93801496
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90515136
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.88176559
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.86913372
15* VDR_24763502_ChIP-Seq_THP-1_Human2.85171489
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.74278305
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.71398380
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67692366
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67692366
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67259094
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.61583686
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60186336
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60045045
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58833378
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51341122
26SCL_19346495_ChIP-Seq_HPC-7_Human2.50335730
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44298403
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43254872
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.35776686
30* MAF_26560356_Chip-Seq_TH1_Human2.35224163
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35072510
32GBX2_23144817_ChIP-Seq_PC3_Human2.34624323
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30342930
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21709759
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21653169
36* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18757205
37* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17721319
38* UTX_26944678_Chip-Seq_JUKART_Human2.15307859
39EZH2_27294783_Chip-Seq_ESCs_Mouse2.14168063
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.10887836
41RUNX1_22412390_ChIP-Seq_EML_Mouse2.10668202
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08387156
43EGR1_19374776_ChIP-ChIP_THP-1_Human2.08028120
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99059686
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98200245
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97774934
47* SPI1_23547873_ChIP-Seq_NB4_Human1.97436433
48* MYB_26560356_Chip-Seq_TH2_Human1.97361112
49* MAF_26560356_Chip-Seq_TH2_Human1.96471785
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.96032485
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94401823
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88871318
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87095561
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.84933865
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84037878
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81508506
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78429254
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77066526
59AR_21572438_ChIP-Seq_LNCaP_Human1.71443681
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70787551
61KDM2B_26808549_Chip-Seq_K562_Human1.69850876
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69252364
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.67303314
64* MYB_26560356_Chip-Seq_TH1_Human1.66364618
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66175688
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64830108
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.64573854
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.57936255
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57635215
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55753729
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55344219
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55260174
73* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.54340768
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52838279
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52738351
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50937849
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44770139
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42766636
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42582372
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41247009
81VDR_24787735_ChIP-Seq_THP-1_Human1.39816484
82* KDM2B_26808549_Chip-Seq_DND41_Human1.38946203
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37253747
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.36557353
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35184666
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.34000337
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32327967
88GATA3_27048872_Chip-Seq_THYMUS_Human1.31967226
89* P68_20966046_ChIP-Seq_HELA_Human1.30593649
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29938904
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29300323
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28465059
93SMAD4_21799915_ChIP-Seq_A2780_Human1.28175886
94* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27828431
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27504698
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27265415
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.26987920
98* LXR_22292898_ChIP-Seq_THP-1_Human1.25921614
99BCOR_27268052_Chip-Seq_Bcells_Human1.24598691
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24308083
101BCL6_27268052_Chip-Seq_Bcells_Human1.23805621
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23715796
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23698465
104GATA1_19941826_ChIP-Seq_K562_Human1.22866413
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22534607
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22061719
107* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20762262
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19982173
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.19178581
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17897355
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16116877
112AR_19668381_ChIP-Seq_PC3_Human1.15907766
113* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15455107
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15253544
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15021919
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11709176
117SPI1_23127762_ChIP-Seq_K562_Human1.11002928
118* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09407795
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08487639
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08284841
121* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08162950
122TET1_21490601_ChIP-Seq_MESCs_Mouse1.05955706
123PU_27001747_Chip-Seq_BMDM_Mouse1.05506295
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05305440
125* CTCF_27219007_Chip-Seq_Bcells_Human1.04400185
126SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03720729
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03016884
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99759855
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99555819
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98799275
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98638481
132SMC4_20622854_ChIP-Seq_HELA_Human0.98516232
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97712958
134RACK7_27058665_Chip-Seq_MCF-7_Human0.97049869
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96973169
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96807633
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96599293
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.96576899
139* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96363653
140NCOR1_26117541_ChIP-Seq_K562_Human0.94895014
141AR_25329375_ChIP-Seq_VCAP_Human0.94841357
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.93755889
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93343453
144* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91306082
145STAT3_23295773_ChIP-Seq_U87_Human0.91006260
146RUNX_20019798_ChIP-Seq_JUKART_Human0.90253918
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90037147
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.89832107
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89559180
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89176240
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.88772308
152* KLF4_19829295_ChIP-Seq_ESCs_Human0.87826511
153TAF15_26573619_Chip-Seq_HEK293_Human0.87337303
154RXR_22108803_ChIP-Seq_LS180_Human0.87031623
155ZNF274_21170338_ChIP-Seq_K562_Hela0.86815495
156OCT4_19829295_ChIP-Seq_ESCs_Human0.86215324
157SMAD4_21741376_ChIP-Seq_ESCs_Human0.82789257
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82284498
159GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81858637
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81280997
161GATA1_19941827_ChIP-Seq_MEL_Mouse0.81089756
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80627446
163TCF7_22412390_ChIP-Seq_EML_Mouse0.80379410
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79906602
165TCF4_23295773_ChIP-Seq_U87_Human0.78780986
166SMAD4_21741376_ChIP-Seq_HESCs_Human0.78137636
167DPY_21335234_ChIP-Seq_ESCs_Mouse0.76918304
168GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76573119
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.76018917
170CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75208164
171AHR_22903824_ChIP-Seq_MCF-7_Human0.73735236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.60473187
2MP0003880_abnormal_central_pattern4.59601568
3MP0003635_abnormal_synaptic_transmissio4.22586154
4MP0004270_analgesia3.81844288
5MP0001968_abnormal_touch/_nociception3.57832623
6MP0003436_decreased_susceptibility_to3.57533582
7MP0009745_abnormal_behavioral_response3.34719685
8MP0002063_abnormal_learning/memory/cond3.30202461
9MP0001835_abnormal_antigen_presentation3.29389713
10* MP0002064_seizures3.16028078
11MP0002735_abnormal_chemical_nociception3.10229062
12MP0002822_catalepsy3.04672915
13MP0005671_abnormal_response_to2.97626112
14MP0002736_abnormal_nociception_after2.92248078
15MP0009046_muscle_twitch2.86741019
16MP0005000_abnormal_immune_tolerance2.69832899
17MP0002734_abnormal_mechanical_nocicepti2.67691321
18MP0002419_abnormal_innate_immunity2.66796700
19MP0002272_abnormal_nervous_system2.66549713
20MP0005423_abnormal_somatic_nervous2.66205881
21MP0002572_abnormal_emotion/affect_behav2.60803959
22MP0005058_abnormal_lysosome_morphology2.57828508
23MP0003763_abnormal_thymus_physiology2.54921508
24MP0004858_abnormal_nervous_system2.52079303
25MP0001800_abnormal_humoral_immune2.50685631
26MP0005025_abnormal_response_to2.50053202
27MP0003724_increased_susceptibility_to2.48628295
28MP0001790_abnormal_immune_system2.44853693
29MP0005387_immune_system_phenotype2.44853693
30MP0001486_abnormal_startle_reflex2.39417192
31MP0006082_CNS_inflammation2.37975799
32MP0000685_abnormal_immune_system2.37748904
33MP0002420_abnormal_adaptive_immunity2.31626007
34MP0002733_abnormal_thermal_nociception2.29936161
35MP0001819_abnormal_immune_cell2.27718610
36MP0002723_abnormal_immune_serum2.27614026
37MP0001970_abnormal_pain_threshold2.27542026
38MP0001501_abnormal_sleep_pattern2.21853618
39MP0002452_abnormal_antigen_presenting2.21725825
40MP0008569_lethality_at_weaning2.21160293
41MP0002148_abnormal_hypersensitivity_rea2.09145581
42MP0003329_amyloid_beta_deposits2.08992046
43MP0005464_abnormal_platelet_physiology2.07779275
44MP0004811_abnormal_neuron_physiology2.04908919
45MP0009278_abnormal_bone_marrow2.02798420
46MP0009785_altered_susceptibility_to1.93477719
47MP0002398_abnormal_bone_marrow1.87861533
48MP0002067_abnormal_sensory_capabilities1.87148286
49MP0002909_abnormal_adrenal_gland1.79532075
50MP0001440_abnormal_grooming_behavior1.78698208
51MP0000716_abnormal_immune_system1.78421756
52MP0009780_abnormal_chondrocyte_physiolo1.74919677
53MP0002405_respiratory_system_inflammati1.67236525
54MP0002396_abnormal_hematopoietic_system1.66814900
55MP0008260_abnormal_autophagy1.65639763
56MP0003191_abnormal_cellular_cholesterol1.63987898
57MP0003633_abnormal_nervous_system1.60976426
58MP0009333_abnormal_splenocyte_physiolog1.60617056
59MP0002184_abnormal_innervation1.60321825
60MP0001533_abnormal_skeleton_physiology1.58488132
61MP0004947_skin_inflammation1.55489972
62MP0003879_abnormal_hair_cell1.53431617
63MP0003075_altered_response_to1.52195505
64MP0000015_abnormal_ear_pigmentation1.52098439
65MP0000955_abnormal_spinal_cord1.50833481
66MP0004924_abnormal_behavior1.48214489
67MP0005386_behavior/neurological_phenoty1.48214489
68MP0000689_abnormal_spleen_morphology1.46545895
69MP0002722_abnormal_immune_system1.45619029
70MP0006276_abnormal_autonomic_nervous1.45008248
71MP0002557_abnormal_social/conspecific_i1.44679062
72MP0000703_abnormal_thymus_morphology1.43020181
73MP0005075_abnormal_melanosome_morpholog1.42677665
74MP0004381_abnormal_hair_follicle1.42216459
75MP0001845_abnormal_inflammatory_respons1.41498589
76MP0010155_abnormal_intestine_physiology1.40936422
77MP0002429_abnormal_blood_cell1.40569610
78MP0004510_myositis1.37267595
79MP0005397_hematopoietic_system_phenotyp1.36680220
80MP0001545_abnormal_hematopoietic_system1.36680220
81MP0002882_abnormal_neuron_morphology1.33706037
82* MP0002066_abnormal_motor_capabilities/c1.32982335
83MP0003787_abnormal_imprinting1.29109529
84MP0001851_eye_inflammation1.27044508
85MP0003172_abnormal_lysosome_physiology1.26148565
86MP0003631_nervous_system_phenotype1.25946239
87MP0000604_amyloidosis1.25508335
88MP0001853_heart_inflammation1.24585851
89MP0005646_abnormal_pituitary_gland1.24179777
90MP0002998_abnormal_bone_remodeling1.23767247
91MP0008961_abnormal_basal_metabolism1.23012406
92MP0004885_abnormal_endolymph1.22219409
93MP0001984_abnormal_olfaction1.20358632
94MP0008874_decreased_physiological_sensi1.19180576
95MP0000569_abnormal_digit_pigmentation1.14449787
96MP0000778_abnormal_nervous_system1.12560499
97MP0005451_abnormal_body_composition1.11926893
98MP0009840_abnormal_foam_cell1.11731404
99MP0000465_gastrointestinal_hemorrhage1.09717095
100MP0002229_neurodegeneration1.08951957
101MP0000920_abnormal_myelination1.08351381
102MP0008469_abnormal_protein_level1.08069134
103MP0001905_abnormal_dopamine_level1.05764798
104MP0008872_abnormal_physiological_respon1.03676759
105MP0003690_abnormal_glial_cell1.03439980
106MP0004142_abnormal_muscle_tone1.02903105
107MP0003303_peritoneal_inflammation1.01442923
108MP0001502_abnormal_circadian_rhythm0.98276751
109MP0003828_pulmonary_edema0.94956690
110MP0001873_stomach_inflammation0.92877165
111MP0004808_abnormal_hematopoietic_stem0.92411582
112MP0003634_abnormal_glial_cell0.90572619
113MP0000858_altered_metastatic_potential0.89421719
114MP0002152_abnormal_brain_morphology0.85502932
115MP0009764_decreased_sensitivity_to0.84639914
116MP0005645_abnormal_hypothalamus_physiol0.84549060
117MP0000343_altered_response_to0.83644293
118MP0002069_abnormal_eating/drinking_beha0.81867293
119MP0005166_decreased_susceptibility_to0.81280310
120MP0001986_abnormal_taste_sensitivity0.79670386
121MP0001529_abnormal_vocalization0.79314664
122MP0005167_abnormal_blood-brain_barrier0.78324476
123MP0000751_myopathy0.76968084
124MP0002166_altered_tumor_susceptibility0.72730386
125MP0003632_abnormal_nervous_system0.72666555
126MP0005551_abnormal_eye_electrophysiolog0.72028990
127MP0003448_altered_tumor_morphology0.69806551
128* MP0005535_abnormal_body_temperature0.69619631
129MP0002090_abnormal_vision0.69325640
130MP0010234_abnormal_vibrissa_follicle0.68294237
131MP0003183_abnormal_peptide_metabolism0.67807578
132MP0005174_abnormal_tail_pigmentation0.67117080
133MP0000371_diluted_coat_color0.66930038
134MP0005310_abnormal_salivary_gland0.65960891
135MP0002933_joint_inflammation0.64365274
136MP0004742_abnormal_vestibular_system0.63612808
137MP0001177_atelectasis0.63510460
138MP0001963_abnormal_hearing_physiology0.62609072
139MP0005394_taste/olfaction_phenotype0.62433659
140MP0005499_abnormal_olfactory_system0.62433659
141MP0003656_abnormal_erythrocyte_physiolo0.61222303
142MP0002877_abnormal_melanocyte_morpholog0.59200491
143MP0003045_fibrosis0.58387494
144MP0004085_abnormal_heartbeat0.57255782
145MP0002752_abnormal_somatic_nervous0.56915579
146MP0010386_abnormal_urinary_bladder0.53659749
147MP0004484_altered_response_of0.52216441
148MP0000013_abnormal_adipose_tissue0.51403348
149MP0000747_muscle_weakness0.50834719
150MP0004130_abnormal_muscle_cell0.50524479
151MP0003866_abnormal_defecation0.47146475
152* MP0003956_abnormal_body_size0.46623799
153MP0001664_abnormal_digestion0.45477568
154MP0003300_gastrointestinal_ulcer0.45435600
155MP0001485_abnormal_pinna_reflex0.45322431
156MP0010769_abnormal_survival0.45266019
157MP0001348_abnormal_lacrimal_gland0.43074277
158MP0001765_abnormal_ion_homeostasis0.43016079
159MP0003122_maternal_imprinting0.42830871
160MP0001943_abnormal_respiration0.42646527
161MP0003283_abnormal_digestive_organ0.42448479
162MP0010768_mortality/aging0.41793151

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.53176129
2Focal motor seizures (HP:0011153)7.30470362
3Focal seizures (HP:0007359)5.66598256
4Visual hallucinations (HP:0002367)5.41505161
5Eczematoid dermatitis (HP:0000976)4.91864410
6Action tremor (HP:0002345)4.82818351
7Supranuclear gaze palsy (HP:0000605)4.58893947
8Atonic seizures (HP:0010819)4.56673259
9Febrile seizures (HP:0002373)4.48223125
10Recurrent abscess formation (HP:0002722)4.46360923
11Recurrent bacterial skin infections (HP:0005406)4.38003763
12Abnormality of macrophages (HP:0004311)4.16461299
13Progressive cerebellar ataxia (HP:0002073)4.13070349
14Absence seizures (HP:0002121)3.98450893
15Epileptic encephalopathy (HP:0200134)3.97138682
16Ankle clonus (HP:0011448)3.88205679
17Papilledema (HP:0001085)3.82933957
18Myositis (HP:0100614)3.76114030
19Increased cerebral lipofuscin (HP:0011813)3.75418824
20Impaired vibration sensation in the lower limbs (HP:0002166)3.75412055
21Abnormality of glycolipid metabolism (HP:0010969)3.71827174
22Abnormality of liposaccharide metabolism (HP:0010968)3.71827174
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.71827174
24Generalized tonic-clonic seizures (HP:0002069)3.70277986
25Dialeptic seizures (HP:0011146)3.63571458
26Depression (HP:0000716)3.61202181
27Abnormality of the lower motor neuron (HP:0002366)3.54448692
28Mediastinal lymphadenopathy (HP:0100721)3.50735183
29Stomatitis (HP:0010280)3.47277499
30Recurrent fungal infections (HP:0002841)3.45621961
31Elevated erythrocyte sedimentation rate (HP:0003565)3.44953630
32Urinary urgency (HP:0000012)3.43049349
33Meningitis (HP:0001287)3.38525365
34Truncal ataxia (HP:0002078)3.36962098
35Urinary bladder sphincter dysfunction (HP:0002839)3.36698831
36Recurrent gram-negative bacterial infections (HP:0005420)3.31089239
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.31018476
38Obstructive lung disease (HP:0006536)3.30276630
39Chronic obstructive pulmonary disease (HP:0006510)3.30276630
40Postural instability (HP:0002172)3.27482393
41Dysmetria (HP:0001310)3.24174133
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.18463948
43Gaze-evoked nystagmus (HP:0000640)3.12848025
44Poor eye contact (HP:0000817)3.12322967
45Cellulitis (HP:0100658)3.08154254
46Recurrent skin infections (HP:0001581)3.07357476
47Ventricular fibrillation (HP:0001663)3.06308866
48Orchitis (HP:0100796)3.04807346
49Recurrent cutaneous fungal infections (HP:0011370)3.01250755
50Chronic mucocutaneous candidiasis (HP:0002728)3.01250755
51Increased IgE level (HP:0003212)3.00793431
52Recurrent viral infections (HP:0004429)3.00557611
53Dysostosis multiplex (HP:0000943)2.95761462
54Impaired social interactions (HP:0000735)2.93926037
55Abnormal social behavior (HP:0012433)2.93926037
56Anxiety (HP:0000739)2.93390293
57Impaired smooth pursuit (HP:0007772)2.93176340
58Mutism (HP:0002300)2.92982440
59Panhypogammaglobulinemia (HP:0003139)2.91132819
60Retrobulbar optic neuritis (HP:0100654)2.90586753
61Optic neuritis (HP:0100653)2.90586753
62Spastic gait (HP:0002064)2.88032621
63Hemiplegia (HP:0002301)2.87193670
64Agammaglobulinemia (HP:0004432)2.85902721
65Insidious onset (HP:0003587)2.85282966
66Termporal pattern (HP:0011008)2.85282966
67Dysdiadochokinesis (HP:0002075)2.84537783
68Insomnia (HP:0100785)2.79615522
69Loss of speech (HP:0002371)2.77239760
70Amblyopia (HP:0000646)2.76587602
71Spontaneous hematomas (HP:0007420)2.73580041
72Torticollis (HP:0000473)2.68650183
73Encephalitis (HP:0002383)2.67652079
74Vasculitis (HP:0002633)2.66026451
75Abnormality of binocular vision (HP:0011514)2.62330674
76Diplopia (HP:0000651)2.62330674
77Bradykinesia (HP:0002067)2.61684851
78Focal dystonia (HP:0004373)2.58547753
79Intention tremor (HP:0002080)2.58527332
80Broad-based gait (HP:0002136)2.58513065
81Abnormality of ocular smooth pursuit (HP:0000617)2.56420042
82Progressive inability to walk (HP:0002505)2.56336112
83Dysmetric saccades (HP:0000641)2.55184154
84Pustule (HP:0200039)2.54870389
85Gastrointestinal inflammation (HP:0004386)2.53477025
86Prolonged bleeding time (HP:0003010)2.50563311
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49576851
88Inflammation of the large intestine (HP:0002037)2.49567247
89Bundle branch block (HP:0011710)2.48231194
90Impaired vibratory sensation (HP:0002495)2.47814400
91Autoimmune thrombocytopenia (HP:0001973)2.46269806
92Gingivitis (HP:0000230)2.45739314
93T lymphocytopenia (HP:0005403)2.44933988
94Scanning speech (HP:0002168)2.43223221
95Colitis (HP:0002583)2.41215453
96Urticaria (HP:0001025)2.37791323
97* Ocular albinism (HP:0001107)2.36947613
98Apathy (HP:0000741)2.35034483
99Gastrointestinal infarctions (HP:0005244)2.33907244
100Gastrointestinal stroma tumor (HP:0100723)2.33238264
101Pulmonary infiltrates (HP:0002113)2.30954252
102Granulocytopenia (HP:0001913)2.29836629
103Ulnar claw (HP:0001178)2.28648629
104* Pointed chin (HP:0000307)2.28243915
105Chest pain (HP:0100749)2.28127157
106Pheochromocytoma (HP:0002666)2.26156240
107Genetic anticipation (HP:0003743)2.25795086
108Abnormality of saccadic eye movements (HP:0000570)2.25789262
109Craniofacial dystonia (HP:0012179)2.25336743
110Rapidly progressive (HP:0003678)2.24847512
111Abnormality of T cells (HP:0002843)2.23961506
112Abnormality of T cell number (HP:0011839)2.23875274
113Megalencephaly (HP:0001355)2.22914254
114Obstructive sleep apnea (HP:0002870)2.20731968
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20173039
116Purpura (HP:0000979)2.20113290
117Neuronal loss in central nervous system (HP:0002529)2.18292182
118Epistaxis (HP:0000421)2.18058696
119Osteomyelitis (HP:0002754)2.17784742
120Peripheral hypomyelination (HP:0007182)2.17536391
121Petechiae (HP:0000967)2.17361921
122Lower limb muscle weakness (HP:0007340)2.17143123
123Amyloidosis (HP:0011034)2.16456689
124Hyperacusis (HP:0010780)2.13786850
125Global brain atrophy (HP:0002283)2.13510083
126Resting tremor (HP:0002322)2.13343352
127Vacuolated lymphocytes (HP:0001922)2.13336124
128Diminished motivation (HP:0000745)2.13087291
129Hemoptysis (HP:0002105)2.11999785
130Hammertoe (HP:0001765)2.11616806
131* Stereotypic behavior (HP:0000733)2.11316094
132Lymphopenia (HP:0001888)2.10800265
133Hypercortisolism (HP:0001578)2.10675120
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09144246
135* Abnormal eating behavior (HP:0100738)2.08249639
136Tetraplegia (HP:0002445)2.06378607
137Abnormality of polysaccharide metabolism (HP:0011012)2.05952171
138Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05952171
139Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05952171
140Rigidity (HP:0002063)2.05755636
141Memory impairment (HP:0002354)2.03844632
142Hepatosplenomegaly (HP:0001433)2.03682002
143Disinhibition (HP:0000734)2.03627945
144Cerebral inclusion bodies (HP:0100314)2.02945372
145Leukocytosis (HP:0001974)2.02556816
146Keratoconjunctivitis sicca (HP:0001097)2.02407791
147Clonus (HP:0002169)2.01813056
148Autoimmune hemolytic anemia (HP:0001890)2.01280338
149Gait ataxia (HP:0002066)2.00668099
150Urinary glycosaminoglycan excretion (HP:0003541)1.98861799
151Mucopolysacchariduria (HP:0008155)1.98861799
152Neurofibrillary tangles (HP:0002185)1.98358382
153Pulmonary embolism (HP:0002204)1.97372517
154Polygenic inheritance (HP:0010982)1.96812048
155Neuroendocrine neoplasm (HP:0100634)1.96604483
156Onion bulb formation (HP:0003383)1.95714184
157IgM deficiency (HP:0002850)1.95698502
158Abnormality of T cell physiology (HP:0011840)1.95472749
159Sepsis (HP:0100806)1.94960065
160Episodic fever (HP:0001954)1.94898233
161Abnormality of cells of the lymphoid lineage (HP:0012140)1.93678851
162Status epilepticus (HP:0002133)1.93057682
163Hemiparesis (HP:0001269)1.91133959
164Ankyloglossia (HP:0010296)1.89733211
165Impaired pain sensation (HP:0007328)1.89558849
166Abnormality of pain sensation (HP:0010832)1.89558849
167Incomplete penetrance (HP:0003829)1.86373832
168Psychosis (HP:0000709)1.84565972
169Delusions (HP:0000746)1.84363052
170Neoplasm of the peripheral nervous system (HP:0100007)1.83988721
171Abnormality of the periventricular white matter (HP:0002518)1.83633916
172Anosmia (HP:0000458)1.83279037
173Lower limb amyotrophy (HP:0007210)1.83192526
174Fetal akinesia sequence (HP:0001989)1.78981731
175Generalized myoclonic seizures (HP:0002123)1.78933828
176Slow saccadic eye movements (HP:0000514)1.77593422
177Deep palmar crease (HP:0006191)1.77200508
178Failure to thrive in infancy (HP:0001531)1.76416198
179Amyotrophic lateral sclerosis (HP:0007354)1.75457102
180Inability to walk (HP:0002540)1.72422396
181Postural tremor (HP:0002174)1.72295881
182Abnormality of the corticospinal tract (HP:0002492)1.72250593
183Inappropriate behavior (HP:0000719)1.72081811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.50049351
2MAP3K94.23611169
3EPHA43.86543742
4KSR23.05459827
5MINK12.99801909
6PRKD32.72491126
7RIPK42.53144810
8DAPK22.52099832
9PAK62.39026518
10CAMKK12.36491669
11MAP3K42.35220267
12MAP3K122.09104039
13BLK2.04613589
14NTRK12.04234192
15FES1.95753332
16TYK21.94375481
17ERN11.91692240
18MAP3K131.89977038
19MAP2K31.89891808
20MAP3K111.87349423
21ARAF1.79226145
22MAP2K71.74924837
23ZAP701.71664242
24DAPK11.65991620
25LMTK21.62288700
26STK381.62130721
27MAP3K21.61845208
28MAP3K141.61601516
29MAP2K41.58869793
30SIK21.56341046
31NTRK21.56315538
32CDK51.55223392
33TXK1.46284528
34BTK1.45378424
35CSK1.45000288
36KIT1.42742362
37IRAK41.42280160
38GRK51.37654465
39TBK11.36879757
40TESK21.35674555
41TAOK11.35481774
42MARK11.35027029
43PRKCH1.33384769
44TNK21.28830288
45PRPF4B1.27469596
46KSR11.27260885
47MAPK121.27232941
48ALK1.22183688
49RET1.21521160
50CDK191.20978544
51TAOK21.19568415
52ITK1.14020226
53RAF11.13915222
54PDK11.13390624
55JAK31.12784025
56TYRO31.10252600
57UHMK11.08509101
58SIK31.07370057
59CSF1R1.06172275
60PRKCG1.05971477
61CAMK11.03836285
62LCK1.01909131
63IKBKE1.01232651
64LYN0.98221433
65MAP3K10.97591335
66SMG10.91477097
67CAMKK20.89175421
68SGK30.87691428
69PTK2B0.87188790
70FGR0.86582185
71TAOK30.86110341
72MAP3K70.85864949
73PDPK10.85687148
74TRIB30.84945328
75SCYL20.84777815
76STK110.84437043
77CDK150.84197332
78CDK180.83664211
79PINK10.82772827
80SGK2230.80639575
81SGK4940.80639575
82MAP3K30.80610015
83CDK140.78995304
84PLK20.77602372
85MARK30.75004650
86CDK11A0.74955744
87MAPK130.72446308
88NEK10.71643982
89TEC0.70490320
90BRSK10.69056080
91IRAK20.67251087
92RIPK10.66876814
93SGK20.66111816
94TNIK0.66067845
95HIPK20.65235203
96IRAK30.64046582
97PHKG10.63977459
98PHKG20.63977459
99PKN20.62556046
100CAMK2A0.61492501
101MARK20.61473759
102MAPK70.61317727
103SYK0.61004627
104MATK0.60933771
105WNK10.60739755
106MAP2K60.59275168
107CDK120.58843680
108MAPK110.58295915
109PRKD20.57218213
110IKBKB0.56252586
111ICK0.56248972
112GRK60.55316690
113FYN0.53711210
114MAP4K10.53130887
115EEF2K0.52012603
116CAMK40.51398346
117SGK10.51200921
118LATS20.50459410
119CAMK2B0.49696754
120MAPK40.49241633
121CDK40.49160775
122RPS6KA20.47339903
123PNCK0.44965771
124RPS6KA30.44834039
125HCK0.43666036
126CDK60.41939014
127DAPK30.41455950
128FGFR30.40959700
129JAK10.39585350
130RPS6KC10.39388465
131RPS6KL10.39388465
132MAP2K10.38727071
133CDC42BPA0.38613909
134LIMK10.38487380
135EPHB10.38319434
136PRKCZ0.36673049
137* MAPK100.34862037
138JAK20.34297486
139PRKCQ0.34278888
140CAMK1G0.33965382
141BMPR20.33907862
142PRKCB0.33371037
143DMPK0.32440848
144PAK30.32417812
145BMX0.31457239
146DYRK1A0.29163914
147ROCK20.28778522

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.27220128
2Olfactory transduction_Homo sapiens_hsa047403.03892691
3Nicotine addiction_Homo sapiens_hsa050332.77007656
4Long-term potentiation_Homo sapiens_hsa047202.66894825
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47968124
6Circadian entrainment_Homo sapiens_hsa047132.44420254
7Glutamatergic synapse_Homo sapiens_hsa047242.28928472
8Leishmaniasis_Homo sapiens_hsa051402.26125103
9GABAergic synapse_Homo sapiens_hsa047272.21616533
10Other glycan degradation_Homo sapiens_hsa005112.19270020
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19187082
12Amphetamine addiction_Homo sapiens_hsa050312.17331679
13Morphine addiction_Homo sapiens_hsa050322.17309203
14Primary immunodeficiency_Homo sapiens_hsa053402.14183473
15Salivary secretion_Homo sapiens_hsa049702.08736288
16Allograft rejection_Homo sapiens_hsa053302.00153138
17Dopaminergic synapse_Homo sapiens_hsa047282.00071363
18Gastric acid secretion_Homo sapiens_hsa049711.96719769
19Graft-versus-host disease_Homo sapiens_hsa053321.95606069
20Cholinergic synapse_Homo sapiens_hsa047251.90415874
21Insulin secretion_Homo sapiens_hsa049111.87054030
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83200309
23Autoimmune thyroid disease_Homo sapiens_hsa053201.81520671
24Staphylococcus aureus infection_Homo sapiens_hsa051501.77774703
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69971407
26Acute myeloid leukemia_Homo sapiens_hsa052211.69573120
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67672038
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65649197
29Oxytocin signaling pathway_Homo sapiens_hsa049211.60698668
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56104100
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.51541058
32GnRH signaling pathway_Homo sapiens_hsa049121.49293831
33Antigen processing and presentation_Homo sapiens_hsa046121.44641430
34Calcium signaling pathway_Homo sapiens_hsa040201.44467151
35Asthma_Homo sapiens_hsa053101.44154108
36Glioma_Homo sapiens_hsa052141.43627737
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41767338
38Renin secretion_Homo sapiens_hsa049241.40749967
39Nitrogen metabolism_Homo sapiens_hsa009101.40066317
40Long-term depression_Homo sapiens_hsa047301.39887441
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.39865177
42Lysosome_Homo sapiens_hsa041421.39438106
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35589124
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31883356
45Taste transduction_Homo sapiens_hsa047421.28156279
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.26801279
47Hematopoietic cell lineage_Homo sapiens_hsa046401.23380637
48Cocaine addiction_Homo sapiens_hsa050301.22028759
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20616412
50Rheumatoid arthritis_Homo sapiens_hsa053231.20325340
51Type II diabetes mellitus_Homo sapiens_hsa049301.19880712
52cAMP signaling pathway_Homo sapiens_hsa040241.19249915
53Serotonergic synapse_Homo sapiens_hsa047261.19225306
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16561919
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16463263
56Gap junction_Homo sapiens_hsa045401.16007818
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15480637
58Measles_Homo sapiens_hsa051621.15040210
59Toxoplasmosis_Homo sapiens_hsa051451.14839319
60Estrogen signaling pathway_Homo sapiens_hsa049151.14060201
61Influenza A_Homo sapiens_hsa051641.10309474
62Viral myocarditis_Homo sapiens_hsa054161.09252335
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06840881
64Collecting duct acid secretion_Homo sapiens_hsa049661.06386564
65VEGF signaling pathway_Homo sapiens_hsa043701.06100486
66Neurotrophin signaling pathway_Homo sapiens_hsa047221.05967291
67ErbB signaling pathway_Homo sapiens_hsa040121.05630135
68Phagosome_Homo sapiens_hsa041451.04480407
69Glycosaminoglycan degradation_Homo sapiens_hsa005311.01924830
70Dorso-ventral axis formation_Homo sapiens_hsa043201.01689417
71Malaria_Homo sapiens_hsa051441.00964968
72Phospholipase D signaling pathway_Homo sapiens_hsa040721.00803182
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98811752
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98157015
75Hepatitis B_Homo sapiens_hsa051610.97241972
76TNF signaling pathway_Homo sapiens_hsa046680.96689331
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96478807
78Oocyte meiosis_Homo sapiens_hsa041140.95406953
79Phototransduction_Homo sapiens_hsa047440.93890189
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92222533
81Chronic myeloid leukemia_Homo sapiens_hsa052200.91440652
82Herpes simplex infection_Homo sapiens_hsa051680.88964035
83Melanogenesis_Homo sapiens_hsa049160.86596299
84Pertussis_Homo sapiens_hsa051330.85971019
85Endocytosis_Homo sapiens_hsa041440.84748568
86Non-small cell lung cancer_Homo sapiens_hsa052230.84617955
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83459343
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.83444884
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.82587180
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82269397
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.81359421
92Pancreatic cancer_Homo sapiens_hsa052120.81150362
93Pancreatic secretion_Homo sapiens_hsa049720.79694086
94Choline metabolism in cancer_Homo sapiens_hsa052310.79122891
95mTOR signaling pathway_Homo sapiens_hsa041500.78704413
96MAPK signaling pathway_Homo sapiens_hsa040100.76975286
97Thyroid hormone synthesis_Homo sapiens_hsa049180.75739467
98Chemokine signaling pathway_Homo sapiens_hsa040620.75233347
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.73599680
100Shigellosis_Homo sapiens_hsa051310.72469067
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72360523
102Legionellosis_Homo sapiens_hsa051340.71275978
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71189911
104Hepatitis C_Homo sapiens_hsa051600.70597888
105T cell receptor signaling pathway_Homo sapiens_hsa046600.69265913
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67581029
107Inositol phosphate metabolism_Homo sapiens_hsa005620.66938627
108Apoptosis_Homo sapiens_hsa042100.66359026
109Axon guidance_Homo sapiens_hsa043600.65742166
110Rap1 signaling pathway_Homo sapiens_hsa040150.65512990
111Vibrio cholerae infection_Homo sapiens_hsa051100.63888128
112Type I diabetes mellitus_Homo sapiens_hsa049400.63258666
113B cell receptor signaling pathway_Homo sapiens_hsa046620.63143596
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62704796
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61776228
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61762257
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59255087
118Epstein-Barr virus infection_Homo sapiens_hsa051690.58065153
119Cardiac muscle contraction_Homo sapiens_hsa042600.57960178
120Glucagon signaling pathway_Homo sapiens_hsa049220.57675428
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56019815
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55431811
123Endometrial cancer_Homo sapiens_hsa052130.55051422
124Ras signaling pathway_Homo sapiens_hsa040140.54266870
125Platelet activation_Homo sapiens_hsa046110.53310287
126Insulin signaling pathway_Homo sapiens_hsa049100.51146696
127Salmonella infection_Homo sapiens_hsa051320.50765640
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.48393226
129Dilated cardiomyopathy_Homo sapiens_hsa054140.48103139
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47550386
131Tuberculosis_Homo sapiens_hsa051520.46800347
132Prolactin signaling pathway_Homo sapiens_hsa049170.46205598
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43310924
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42734737
135Osteoclast differentiation_Homo sapiens_hsa043800.42210762
136Renal cell carcinoma_Homo sapiens_hsa052110.42193722
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41728524
138HIF-1 signaling pathway_Homo sapiens_hsa040660.41451308
139Prion diseases_Homo sapiens_hsa050200.39213514
140Alcoholism_Homo sapiens_hsa050340.38799304
141African trypanosomiasis_Homo sapiens_hsa051430.38518311
142Bile secretion_Homo sapiens_hsa049760.36894068
143Colorectal cancer_Homo sapiens_hsa052100.36844825

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