KCNAB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.53523404
2synaptic vesicle maturation (GO:0016188)6.15840902
3behavioral response to nicotine (GO:0035095)5.98515119
4synaptic vesicle exocytosis (GO:0016079)5.97443393
5glutamate secretion (GO:0014047)5.91723385
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.76338003
7neuronal action potential propagation (GO:0019227)5.75014772
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63901375
9regulation of synaptic vesicle exocytosis (GO:2000300)5.55659647
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55499214
11locomotory exploration behavior (GO:0035641)5.51109444
12vocalization behavior (GO:0071625)5.48229620
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22036770
14neurotransmitter secretion (GO:0007269)5.04310907
15regulation of synaptic vesicle transport (GO:1902803)4.91567625
16regulation of glutamate receptor signaling pathway (GO:1900449)4.89524674
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.62402455
18protein localization to synapse (GO:0035418)4.62087977
19regulation of neuronal synaptic plasticity (GO:0048168)4.48754502
20fucose catabolic process (GO:0019317)4.48015617
21L-fucose metabolic process (GO:0042354)4.48015617
22L-fucose catabolic process (GO:0042355)4.48015617
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.44777904
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.39172818
25synaptic transmission, glutamatergic (GO:0035249)4.34740697
26gamma-aminobutyric acid transport (GO:0015812)4.32640974
27neuron-neuron synaptic transmission (GO:0007270)4.27760183
28neuron cell-cell adhesion (GO:0007158)4.18123352
29neuromuscular process controlling posture (GO:0050884)4.17876449
30glutamate receptor signaling pathway (GO:0007215)4.10689313
31neurotransmitter-gated ion channel clustering (GO:0072578)4.07225159
32cellular potassium ion homeostasis (GO:0030007)4.04260110
33exploration behavior (GO:0035640)4.02960223
34glycine transport (GO:0015816)4.02334792
35neurotransmitter transport (GO:0006836)4.02050106
36cerebellar Purkinje cell differentiation (GO:0021702)4.00846590
37positive regulation of synapse maturation (GO:0090129)3.97119217
38layer formation in cerebral cortex (GO:0021819)3.96589726
39long-term memory (GO:0007616)3.96268819
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.91009163
41positive regulation of membrane potential (GO:0045838)3.87313304
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83403723
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.83325811
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.82370191
45regulation of synaptic plasticity (GO:0048167)3.77761008
46proline transport (GO:0015824)3.75073618
47long-term synaptic potentiation (GO:0060291)3.72279162
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68798445
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.67793692
50regulation of postsynaptic membrane potential (GO:0060078)3.65490538
51sodium ion export (GO:0071436)3.64304106
52regulation of neurotransmitter secretion (GO:0046928)3.64057734
53regulation of neurotransmitter levels (GO:0001505)3.63226818
54synaptic vesicle endocytosis (GO:0048488)3.58071911
55activation of protein kinase A activity (GO:0034199)3.57268451
56negative regulation of telomere maintenance (GO:0032205)3.45480925
57regulation of synapse structural plasticity (GO:0051823)3.41846895
58dendritic spine morphogenesis (GO:0060997)3.41099438
59cerebellar granule cell differentiation (GO:0021707)3.40205677
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35425950
61neuromuscular process controlling balance (GO:0050885)3.34682745
62regulation of dendritic spine morphogenesis (GO:0061001)3.34426013
63primary amino compound metabolic process (GO:1901160)3.32296932
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.31258093
65regulation of neurotransmitter transport (GO:0051588)3.30876525
66positive regulation of neurotransmitter transport (GO:0051590)3.29461487
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29116660
68L-amino acid import (GO:0043092)3.29048167
69serotonin metabolic process (GO:0042428)3.28433195
70transmission of nerve impulse (GO:0019226)3.26934955
71neuron recognition (GO:0008038)3.26933682
72long term synaptic depression (GO:0060292)3.23764165
73regulation of vesicle fusion (GO:0031338)3.20845205
74presynaptic membrane assembly (GO:0097105)3.20074185
75positive regulation of neurotransmitter secretion (GO:0001956)3.17553500
76piRNA metabolic process (GO:0034587)3.17207504
77membrane hyperpolarization (GO:0060081)3.16002393
78membrane depolarization (GO:0051899)3.15261429
79membrane depolarization during action potential (GO:0086010)3.14116897
80positive regulation of synaptic transmission (GO:0050806)3.13656049
81regulation of synaptic transmission (GO:0050804)3.10828056
82neuromuscular process (GO:0050905)3.09261933
83* synaptic transmission (GO:0007268)3.08816548
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07297581
85presynaptic membrane organization (GO:0097090)3.06821727
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06683374
87cell communication by electrical coupling (GO:0010644)3.05461282
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05384548
89postsynaptic membrane organization (GO:0001941)3.03221742
90neuronal ion channel clustering (GO:0045161)3.03144990
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03055407
92learning (GO:0007612)3.02968679
93retinal cone cell development (GO:0046549)3.02416351
94regulation of voltage-gated calcium channel activity (GO:1901385)3.01294952
95calcium ion-dependent exocytosis (GO:0017156)3.00978845
96neuronal action potential (GO:0019228)3.00933665
97vesicle transport along microtubule (GO:0047496)2.99782778
98adult walking behavior (GO:0007628)2.99646857
99positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99156868
100regulation of synapse maturation (GO:0090128)2.98703122
101detection of calcium ion (GO:0005513)2.97840461
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96570045
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96092707
104regulation of neurotransmitter uptake (GO:0051580)2.93965408
105social behavior (GO:0035176)2.92958503
106intraspecies interaction between organisms (GO:0051703)2.92958503
107potassium ion import (GO:0010107)2.92784440
108DNA deamination (GO:0045006)2.92113656
109axonal fasciculation (GO:0007413)2.91832132
110auditory behavior (GO:0031223)2.91276859
111regulation of clathrin-mediated endocytosis (GO:2000369)2.90561169
112signal release (GO:0023061)2.89665435
113startle response (GO:0001964)2.88790323
114mating behavior (GO:0007617)2.88272837
115nephron epithelium morphogenesis (GO:0072088)2.88049026
116nephron tubule morphogenesis (GO:0072078)2.88049026
117detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87296997
118mechanosensory behavior (GO:0007638)2.85834405
119indolalkylamine metabolic process (GO:0006586)2.85404078
120cAMP catabolic process (GO:0006198)2.83548392
121protein K11-linked deubiquitination (GO:0035871)2.82180368
122indole-containing compound metabolic process (GO:0042430)2.82003356
123DNA methylation involved in gamete generation (GO:0043046)2.80601820
124detection of light stimulus involved in visual perception (GO:0050908)2.80129193
125detection of light stimulus involved in sensory perception (GO:0050962)2.80129193
126tryptophan catabolic process (GO:0006569)2.75483202
127indole-containing compound catabolic process (GO:0042436)2.75483202
128indolalkylamine catabolic process (GO:0046218)2.75483202
129regulation of calcium ion-dependent exocytosis (GO:0017158)2.75244433
130neuromuscular synaptic transmission (GO:0007274)2.74763861
131cyclic nucleotide catabolic process (GO:0009214)2.71657644
132phosphorelay signal transduction system (GO:0000160)2.70399195
133alanine transport (GO:0032328)2.70363408
134response to pheromone (GO:0019236)2.66297666
135regulation of telomere maintenance (GO:0032204)2.65913489
136response to amphetamine (GO:0001975)2.65346049
137alkaloid metabolic process (GO:0009820)2.63354649
138regulation of nuclear cell cycle DNA replication (GO:0033262)2.60098965
139regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58610123
140* potassium ion transmembrane transport (GO:0071805)2.57862317
141* cellular potassium ion transport (GO:0071804)2.57862317
142lysosome localization (GO:0032418)2.56649141
143positive regulation of CREB transcription factor activity (GO:0032793)2.56613853
144axoneme assembly (GO:0035082)2.55596497
145protein complex biogenesis (GO:0070271)2.54283675
146synaptic transmission, cholinergic (GO:0007271)2.54159106
147rhodopsin mediated signaling pathway (GO:0016056)2.53576531
148negative regulation of cAMP-mediated signaling (GO:0043951)2.52398454
149axon ensheathment in central nervous system (GO:0032291)2.51431830
150central nervous system myelination (GO:0022010)2.51431830
151kynurenine metabolic process (GO:0070189)2.51259519
152positive regulation of meiosis (GO:0045836)2.51152701
153urinary tract smooth muscle contraction (GO:0014848)2.50677200
154* potassium ion transport (GO:0006813)2.50537532
155protein polyglutamylation (GO:0018095)2.48307697
156phosphate ion homeostasis (GO:0055062)2.47528715
157trivalent inorganic anion homeostasis (GO:0072506)2.47528715
158behavioral response to ethanol (GO:0048149)2.46081075
159regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.44630787
160regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.44630787
161regulation of respiratory system process (GO:0044065)2.44201994
162synapse assembly (GO:0007416)2.43448276
163tryptophan metabolic process (GO:0006568)2.43272078
164NADH dehydrogenase complex assembly (GO:0010257)2.42134089
165mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.42134089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45148794
2GBX2_23144817_ChIP-Seq_PC3_Human3.36818052
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15661117
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04281160
5REST_21632747_ChIP-Seq_MESCs_Mouse2.97883243
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95831364
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.92990547
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72668218
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72668218
10DROSHA_22980978_ChIP-Seq_HELA_Human2.65282124
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61310537
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55808689
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54712952
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53737244
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50180008
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.47957135
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37426327
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.34530433
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23758686
20IGF1R_20145208_ChIP-Seq_DFB_Human2.19687613
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.17341611
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.17278828
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15911521
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14135950
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.11956005
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10308926
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99569138
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99501138
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98974809
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92170399
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.76776725
32BCAT_22108803_ChIP-Seq_LS180_Human1.73591051
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65695471
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62517908
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59378212
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59083509
37TAF15_26573619_Chip-Seq_HEK293_Human1.52817496
38ER_23166858_ChIP-Seq_MCF-7_Human1.52752770
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52427336
40AR_21572438_ChIP-Seq_LNCaP_Human1.52268279
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50916131
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50748804
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.50467316
44EWS_26573619_Chip-Seq_HEK293_Human1.46286122
45* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45573570
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40279007
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39325011
48TP53_22573176_ChIP-Seq_HFKS_Human1.39026750
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35958743
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.32738997
51ZNF274_21170338_ChIP-Seq_K562_Hela1.32170093
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30389556
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30102149
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29583235
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28721010
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28308197
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27221903
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25852854
59AR_19668381_ChIP-Seq_PC3_Human1.25631053
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20959507
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.20240008
62P300_19829295_ChIP-Seq_ESCs_Human1.20092971
63STAT3_23295773_ChIP-Seq_U87_Human1.19382075
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19124008
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18825361
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18406634
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17707213
68KDM2B_26808549_Chip-Seq_K562_Human1.17531410
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17424432
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.17235346
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.16819571
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16640192
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.15913925
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.15883255
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15787048
76AR_25329375_ChIP-Seq_VCAP_Human1.15386933
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15026450
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14348680
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13815108
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12558070
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12303186
82* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10477990
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.10457351
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10235656
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.10006978
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09513246
87CBP_20019798_ChIP-Seq_JUKART_Human1.08639713
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08639713
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08468085
90HOXB7_26014856_ChIP-Seq_BT474_Human1.07378593
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07231759
92TCF4_23295773_ChIP-Seq_U87_Human1.06999599
93MYC_18940864_ChIP-ChIP_HL60_Human1.06323106
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06146298
95NCOR_22424771_ChIP-Seq_293T_Human1.05348035
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05330755
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.05272525
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04305784
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04119595
100IRF1_19129219_ChIP-ChIP_H3396_Human1.03991742
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.03537856
102SOX2_19829295_ChIP-Seq_ESCs_Human1.03044887
103NANOG_19829295_ChIP-Seq_ESCs_Human1.03044887
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02904712
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.02665571
106ERA_21632823_ChIP-Seq_H3396_Human1.02364597
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02238516
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01956654
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01232141
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00686779
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.00597558
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00484397
113TCF4_22108803_ChIP-Seq_LS180_Human1.00407244
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00258432
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99717248
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.98757410
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98622245
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.98371645
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.97981092
120MYC_19829295_ChIP-Seq_ESCs_Human0.97260080
121AHR_22903824_ChIP-Seq_MCF-7_Human0.96251641
122RNF2_27304074_Chip-Seq_NSC_Mouse0.96225648
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.94829927
124* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90648226
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90619250
126VDR_22108803_ChIP-Seq_LS180_Human0.88888111
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88845554
128RUNX2_22187159_ChIP-Seq_PCA_Human0.87966794
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87068331
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86559937
131FUS_26573619_Chip-Seq_HEK293_Human0.85953566
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.85935065
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.84148847
134TP53_16413492_ChIP-PET_HCT116_Human0.82199785
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80505060
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79286257
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78040611
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77876808
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77181409
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77181409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.53050453
2MP0003880_abnormal_central_pattern4.96297298
3MP0003635_abnormal_synaptic_transmissio4.26444705
4MP0004270_analgesia3.60351025
5MP0009046_muscle_twitch3.52853980
6MP0009745_abnormal_behavioral_response3.46724092
7MP0002064_seizures3.42423541
8MP0002063_abnormal_learning/memory/cond3.28387515
9MP0002572_abnormal_emotion/affect_behav2.84071181
10MP0002272_abnormal_nervous_system2.83165014
11MP0000569_abnormal_digit_pigmentation2.70075313
12MP0001486_abnormal_startle_reflex2.68867693
13MP0001968_abnormal_touch/_nociception2.63446137
14MP0001986_abnormal_taste_sensitivity2.54954465
15MP0001501_abnormal_sleep_pattern2.53679059
16MP0002734_abnormal_mechanical_nocicepti2.50590014
17MP0002138_abnormal_hepatobiliary_system2.31455102
18MP0005423_abnormal_somatic_nervous2.28554362
19MP0008569_lethality_at_weaning2.25206280
20MP0009780_abnormal_chondrocyte_physiolo2.18575485
21MP0002822_catalepsy2.14637088
22MP0002067_abnormal_sensory_capabilities2.08033181
23MP0002909_abnormal_adrenal_gland2.06614614
24MP0002736_abnormal_nociception_after2.04702715
25MP0003787_abnormal_imprinting2.03889339
26MP0001440_abnormal_grooming_behavior2.00653184
27MP0003329_amyloid_beta_deposits1.88875439
28MP0001970_abnormal_pain_threshold1.87533550
29MP0002733_abnormal_thermal_nociception1.85440669
30MP0005646_abnormal_pituitary_gland1.84592140
31MP0002735_abnormal_chemical_nociception1.77113591
32MP0004811_abnormal_neuron_physiology1.74152798
33MP0002184_abnormal_innervation1.67801019
34MP0002557_abnormal_social/conspecific_i1.67336323
35MP0006292_abnormal_olfactory_placode1.63780767
36MP0004924_abnormal_behavior1.62434149
37MP0005386_behavior/neurological_phenoty1.62434149
38MP0003879_abnormal_hair_cell1.56935774
39MP0000955_abnormal_spinal_cord1.55469428
40MP0002102_abnormal_ear_morphology1.53871673
41MP0004142_abnormal_muscle_tone1.53255482
42MP0003283_abnormal_digestive_organ1.50671314
43MP0002066_abnormal_motor_capabilities/c1.46921522
44MP0000778_abnormal_nervous_system1.46227874
45MP0004885_abnormal_endolymph1.46051229
46MP0001984_abnormal_olfaction1.45678744
47MP0008875_abnormal_xenobiotic_pharmacok1.45469870
48MP0004858_abnormal_nervous_system1.40490764
49MP0002882_abnormal_neuron_morphology1.39974500
50MP0000013_abnormal_adipose_tissue1.39898764
51MP0003633_abnormal_nervous_system1.38648219
52MP0001502_abnormal_circadian_rhythm1.35165136
53MP0005174_abnormal_tail_pigmentation1.33528922
54MP0003122_maternal_imprinting1.31350461
55MP0000427_abnormal_hair_cycle1.28188019
56MP0003121_genomic_imprinting1.26755130
57MP0010386_abnormal_urinary_bladder1.21048167
58MP0002160_abnormal_reproductive_system1.19800925
59MP0003631_nervous_system_phenotype1.17824998
60MP0006276_abnormal_autonomic_nervous1.17176141
61MP0005551_abnormal_eye_electrophysiolog1.14070381
62MP0004147_increased_porphyrin_level1.11755171
63MP0004043_abnormal_pH_regulation1.11194257
64MP0000372_irregular_coat_pigmentation1.10563233
65MP0005645_abnormal_hypothalamus_physiol1.08237674
66MP0002152_abnormal_brain_morphology1.07520935
67MP0002876_abnormal_thyroid_physiology1.07451578
68MP0004233_abnormal_muscle_weight1.07377510
69MP0004133_heterotaxia1.07150304
70MP0002229_neurodegeneration1.06979251
71MP0003136_yellow_coat_color1.06940982
72MP0002837_dystrophic_cardiac_calcinosis1.06752683
73MP0005253_abnormal_eye_physiology1.06665877
74MP0000751_myopathy1.06566205
75MP0004145_abnormal_muscle_electrophysio1.04788752
76MP0008872_abnormal_physiological_respon1.01925368
77MP0002928_abnormal_bile_duct1.01736702
78MP0005389_reproductive_system_phenotype0.99865584
79MP0000026_abnormal_inner_ear0.99590346
80MP0003195_calcinosis0.98308179
81MP0008961_abnormal_basal_metabolism0.94180142
82MP0002069_abnormal_eating/drinking_beha0.92633504
83MP0005499_abnormal_olfactory_system0.92205546
84MP0005394_taste/olfaction_phenotype0.92205546
85MP0008877_abnormal_DNA_methylation0.90971638
86MP0002938_white_spotting0.90599783
87MP0003690_abnormal_glial_cell0.89614579
88MP0003632_abnormal_nervous_system0.88998290
89MP0008874_decreased_physiological_sensi0.88137724
90MP0001529_abnormal_vocalization0.88071898
91MP0008995_early_reproductive_senescence0.86839753
92MP0001905_abnormal_dopamine_level0.86071551
93MP0005535_abnormal_body_temperature0.84713928
94MP0001177_atelectasis0.84691675
95MP0003938_abnormal_ear_development0.84344009
96MP0001963_abnormal_hearing_physiology0.82630726
97MP0001485_abnormal_pinna_reflex0.82620919
98MP0003634_abnormal_glial_cell0.82382257
99MP0005084_abnormal_gallbladder_morpholo0.81085230
100MP0005171_absent_coat_pigmentation0.80502257
101MP0000920_abnormal_myelination0.78932085
102MP0004085_abnormal_heartbeat0.77683628
103MP0004742_abnormal_vestibular_system0.77104927
104MP0005195_abnormal_posterior_eye0.76982994
105MP0003646_muscle_fatigue0.76634447
106MP0000604_amyloidosis0.75522014
107MP0002638_abnormal_pupillary_reflex0.73941405
108MP0006072_abnormal_retinal_apoptosis0.73277032
109MP0000631_abnormal_neuroendocrine_gland0.72190106
110MP0002277_abnormal_respiratory_mucosa0.71926725
111MP0003698_abnormal_male_reproductive0.71063105
112MP0002752_abnormal_somatic_nervous0.70922692
113MP0004130_abnormal_muscle_cell0.68671084
114MP0005220_abnormal_exocrine_pancreas0.68346434
115MP0003172_abnormal_lysosome_physiology0.68273813
116MP0001188_hyperpigmentation0.68141771
117MP0000383_abnormal_hair_follicle0.66727187
118MP0004215_abnormal_myocardial_fiber0.65758365
119MP0005410_abnormal_fertilization0.65593668
120MP0003123_paternal_imprinting0.65546390
121MP0002095_abnormal_skin_pigmentation0.65049692
122MP0002653_abnormal_ependyma_morphology0.64723921
123MP0002090_abnormal_vision0.64577390
124MP0003075_altered_response_to0.64532043
125MP0001944_abnormal_pancreas_morphology0.64204349
126MP0001919_abnormal_reproductive_system0.63721925
127MP0004484_altered_response_of0.63639084
128MP0005623_abnormal_meninges_morphology0.62417155
129MP0001765_abnormal_ion_homeostasis0.62058271
130MP0005187_abnormal_penis_morphology0.61998672
131MP0003137_abnormal_impulse_conducting0.60242694
132MP0010769_abnormal_survival0.59941981
133MP0010770_preweaning_lethality0.57356707
134MP0002082_postnatal_lethality0.57356707
135MP0001943_abnormal_respiration0.56612365
136MP0010768_mortality/aging0.56551021
137MP0001664_abnormal_digestion0.55971569

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.68277318
2Myokymia (HP:0002411)6.12964277
3Atonic seizures (HP:0010819)6.12852121
4Focal seizures (HP:0007359)5.99667760
5Epileptic encephalopathy (HP:0200134)5.81704988
6Febrile seizures (HP:0002373)5.52710771
7Visual hallucinations (HP:0002367)5.24038537
8Congenital stationary night blindness (HP:0007642)4.92763931
9Absence seizures (HP:0002121)4.72620821
10Pancreatic cysts (HP:0001737)4.28049567
11Dialeptic seizures (HP:0011146)4.22868814
12Progressive cerebellar ataxia (HP:0002073)4.14109146
13Generalized tonic-clonic seizures (HP:0002069)4.13376794
14Pancreatic fibrosis (HP:0100732)4.01880629
15Molar tooth sign on MRI (HP:0002419)3.99851196
16Abnormality of midbrain morphology (HP:0002418)3.99851196
17True hermaphroditism (HP:0010459)3.97563488
18Nephronophthisis (HP:0000090)3.82864218
19Hyperventilation (HP:0002883)3.80221822
20Action tremor (HP:0002345)3.74135863
21Gaze-evoked nystagmus (HP:0000640)3.55255423
22Supranuclear gaze palsy (HP:0000605)3.50071588
23Poor eye contact (HP:0000817)3.44893329
24Broad-based gait (HP:0002136)3.38387685
25Impaired social interactions (HP:0000735)3.32569838
26Abnormal social behavior (HP:0012433)3.32569838
27Dysdiadochokinesis (HP:0002075)3.31352315
28Depression (HP:0000716)3.17310424
29Abnormality of the renal medulla (HP:0100957)3.16646928
30Abnormal rod and cone electroretinograms (HP:0008323)3.13351282
31Abnormality of the lower motor neuron (HP:0002366)3.10399850
32Status epilepticus (HP:0002133)3.03529678
33Amblyopia (HP:0000646)3.01208828
34Truncal ataxia (HP:0002078)3.00469140
35Impaired vibration sensation in the lower limbs (HP:0002166)2.99722730
36Cystic liver disease (HP:0006706)2.99219225
37Impaired smooth pursuit (HP:0007772)2.98031653
38Dysmetria (HP:0001310)2.97578568
39Ankle clonus (HP:0011448)2.96469394
40Polydipsia (HP:0001959)2.95259977
41Abnormal drinking behavior (HP:0030082)2.95259977
42Abnormal eating behavior (HP:0100738)2.85435695
43Chronic hepatic failure (HP:0100626)2.84309023
44Anxiety (HP:0000739)2.81508232
45Postural instability (HP:0002172)2.76009490
46Type II lissencephaly (HP:0007260)2.74896093
47Epileptiform EEG discharges (HP:0011182)2.66733749
48Hemiplegia (HP:0002301)2.66730937
49Urinary bladder sphincter dysfunction (HP:0002839)2.64111874
50Attenuation of retinal blood vessels (HP:0007843)2.62743362
51Hemiparesis (HP:0001269)2.62509962
52Congenital, generalized hypertrichosis (HP:0004540)2.62295442
53Progressive inability to walk (HP:0002505)2.62248912
54Bile duct proliferation (HP:0001408)2.61977066
55Abnormal biliary tract physiology (HP:0012439)2.61977066
56Abnormality of the renal cortex (HP:0011035)2.57407823
57Dysmetric saccades (HP:0000641)2.55370471
58Abnormality of ocular smooth pursuit (HP:0000617)2.53164823
59EEG with generalized epileptiform discharges (HP:0011198)2.53121375
60Pheochromocytoma (HP:0002666)2.52789022
61Genetic anticipation (HP:0003743)2.52434623
62Limb dystonia (HP:0002451)2.49250262
63Annular pancreas (HP:0001734)2.48627751
64Intention tremor (HP:0002080)2.48169660
65Diplopia (HP:0000651)2.46727102
66Abnormality of binocular vision (HP:0011514)2.46727102
67Scanning speech (HP:0002168)2.45903540
68Urinary urgency (HP:0000012)2.43343784
69Fair hair (HP:0002286)2.43035355
70Hypsarrhythmia (HP:0002521)2.42734574
71Ventricular fibrillation (HP:0001663)2.37529213
72Absent speech (HP:0001344)2.37221677
73Drooling (HP:0002307)2.36725672
74Excessive salivation (HP:0003781)2.36725672
75Medial flaring of the eyebrow (HP:0010747)2.35842379
76Papilledema (HP:0001085)2.35494996
77Spastic gait (HP:0002064)2.35472936
78Bradykinesia (HP:0002067)2.34483934
79Tubular atrophy (HP:0000092)2.32249309
80Pendular nystagmus (HP:0012043)2.26050506
81Polyuria (HP:0000103)2.25523214
82Congenital hepatic fibrosis (HP:0002612)2.24721873
83Stereotypic behavior (HP:0000733)2.24222942
84Large for gestational age (HP:0001520)2.23636169
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22639213
86Generalized myoclonic seizures (HP:0002123)2.21518594
87Abnormality of DNA repair (HP:0003254)2.19388325
88Anencephaly (HP:0002323)2.18669530
89Gait ataxia (HP:0002066)2.16331476
90Neuroendocrine neoplasm (HP:0100634)2.14669586
91Torticollis (HP:0000473)2.13557553
92Inability to walk (HP:0002540)2.13541185
93Cerebral inclusion bodies (HP:0100314)2.13213129
94Decreased central vision (HP:0007663)2.12576987
95Neurofibrillary tangles (HP:0002185)2.10704205
96Abnormality of the pons (HP:0007361)2.10263262
97Resting tremor (HP:0002322)2.08936191
98Termporal pattern (HP:0011008)2.08600148
99Insidious onset (HP:0003587)2.08600148
100Polyphagia (HP:0002591)2.08132410
101Bundle branch block (HP:0011710)2.07353714
102Impaired vibratory sensation (HP:0002495)2.07241706
103Fetal akinesia sequence (HP:0001989)2.06260642
104Agitation (HP:0000713)2.05160846
105Hypoplasia of the pons (HP:0012110)2.03484721
106Lissencephaly (HP:0001339)2.02903296
107Focal dystonia (HP:0004373)2.02802924
108Rib fusion (HP:0000902)2.02356105
109Sclerocornea (HP:0000647)2.00721064
110Stomach cancer (HP:0012126)2.00481033
111Furrowed tongue (HP:0000221)1.96019860
112Progressive microcephaly (HP:0000253)1.94302673
113Thickened helices (HP:0000391)1.93916230
114Neuronal loss in central nervous system (HP:0002529)1.93747524
115Hypothermia (HP:0002045)1.93598710
116Failure to thrive in infancy (HP:0001531)1.93456516
117Mutism (HP:0002300)1.92912376
118Megalencephaly (HP:0001355)1.92641536
119Abolished electroretinogram (ERG) (HP:0000550)1.91788367
120Increased hepatocellular lipid droplets (HP:0006565)1.91156195
121Nephrogenic diabetes insipidus (HP:0009806)1.90426124
122Protruding tongue (HP:0010808)1.89570431
123Optic nerve hypoplasia (HP:0000609)1.89547667
124Lower limb muscle weakness (HP:0007340)1.89498644
125Male pseudohermaphroditism (HP:0000037)1.89385408
126Lipid accumulation in hepatocytes (HP:0006561)1.89140265
127Pointed chin (HP:0000307)1.87292531
128Ulnar claw (HP:0001178)1.86034193
129Delusions (HP:0000746)1.84386918
130Abnormality of saccadic eye movements (HP:0000570)1.84339946
131Congenital primary aphakia (HP:0007707)1.83842174
132Generalized hypopigmentation of hair (HP:0011358)1.83732904
133Insomnia (HP:0100785)1.82963523
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.82333833
135Neoplasm of the peripheral nervous system (HP:0100007)1.82105682
136Abnormality of renal excretion (HP:0011036)1.80526724
137Patellar aplasia (HP:0006443)1.80507834
138Spastic tetraparesis (HP:0001285)1.79561124
139Spinal canal stenosis (HP:0003416)1.78208459
140Amyotrophic lateral sclerosis (HP:0007354)1.78176811
141Gait imbalance (HP:0002141)1.76343069
142Clonus (HP:0002169)1.75838832
143Abnormality of renal resorption (HP:0011038)1.75656690
144Specific learning disability (HP:0001328)1.74623045
145Postaxial foot polydactyly (HP:0001830)1.74264076
146Central scotoma (HP:0000603)1.74060196
147Aplasia/Hypoplasia of the patella (HP:0006498)1.73884158
148Craniofacial dystonia (HP:0012179)1.73806826
149Dyskinesia (HP:0100660)1.73764516
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73462398
151Blue irides (HP:0000635)1.73113456
152Bony spicule pigmentary retinopathy (HP:0007737)1.72758985
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72029257
154Clumsiness (HP:0002312)1.72015336
155Tetraplegia (HP:0002445)1.71848454
156Hyperthyroidism (HP:0000836)1.71612112
157Concave nail (HP:0001598)1.69789038
158Abnormal urine output (HP:0012590)1.69711211
159Postural tremor (HP:0002174)1.69557812
160Rigidity (HP:0002063)1.69423008
161Limb ataxia (HP:0002070)1.68960306
162Abnormality of the periventricular white matter (HP:0002518)1.68916903
163Incomplete penetrance (HP:0003829)1.68320903
164Widely spaced teeth (HP:0000687)1.67721560
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65853038
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65174680
167Increased corneal curvature (HP:0100692)1.64480906
168Keratoconus (HP:0000563)1.64480906
169Mitochondrial inheritance (HP:0001427)1.64059186
170Severe muscular hypotonia (HP:0006829)1.62035147
171Hypoplastic ischia (HP:0003175)1.61557039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.31908183
2EPHA44.10212187
3FRK4.03464945
4MAP3K93.71303162
5MAP3K43.51032343
6BMPR1B3.28866019
7MAP2K72.88452864
8DAPK22.65753196
9MAP4K22.49277809
10ADRBK22.44570144
11MINK12.40531426
12TAOK32.34748183
13PAK62.34681390
14MAP2K42.33510816
15PRKD32.28758330
16WNK32.24839140
17STK392.19078943
18TLK12.18568267
19MAP3K122.16668858
20CASK2.14297390
21CDK192.11992284
22RIPK42.08178053
23CAMKK12.05467558
24KSR21.89752458
25GRK11.86371077
26DAPK11.85957672
27PNCK1.81167665
28NTRK21.75300258
29TXK1.71522455
30MARK11.69985508
31NTRK11.67810627
32ACVR1B1.67404075
33UHMK11.61456642
34PLK21.57164148
35STK381.55976728
36NUAK11.51274936
37CDK51.49443934
38GRK51.42465557
39TYRO31.34124305
40KSR11.31139327
41BMPR21.27333274
42PRPF4B1.24713487
43PINK11.23602757
44CAMKK21.22077931
45SIK21.21282430
46PRKCG1.19622708
47MAPKAPK51.17798425
48ARAF1.17379066
49WNK11.16268605
50AKT31.15122642
51FGFR21.12678620
52OXSR11.04082489
53BCKDK1.03952081
54MAP3K130.96470202
55SGK4940.95571995
56SGK2230.95571995
57PRKCH0.94569796
58MAP3K20.93279935
59TNK20.92160457
60CDK180.91159555
61CDK150.90609963
62MAP4K10.90135570
63MKNK20.89991894
64BRD40.88213095
65TRIM280.88044545
66CCNB10.87921704
67FES0.87486427
68STK110.86806458
69MAPK130.86544119
70CAMK2A0.85402868
71CDK140.82614893
72ZAK0.81285908
73CAMK10.79879006
74MAPK150.79778078
75MAPKAPK30.79653097
76CDK11A0.78750057
77CDC42BPA0.78093628
78MAP2K60.78010696
79CAMK2B0.76211659
80SGK20.75316015
81RET0.75044835
82TNIK0.74965678
83PKN10.74255374
84ALK0.73318922
85ADRBK10.72513089
86TGFBR10.72455437
87SGK30.70528410
88PRKCQ0.69089381
89DYRK1A0.68820164
90NEK10.67502334
91MAP3K10.66463673
92SCYL20.65817411
93SGK10.62868170
94RAF10.62809643
95PTK2B0.62785700
96PAK30.62733058
97PDK10.62022348
98TAOK10.61502298
99PDPK10.61253092
100STK38L0.59205314
101LATS20.58748453
102MAP3K60.58550596
103NEK60.58186781
104PRKD20.56271475
105BRSK10.56148493
106SYK0.54498389
107IKBKB0.54405750
108CAMK1G0.52310133
109STK160.52219307
110INSRR0.51923847
111ITK0.51495085
112MAPK120.50201490
113CAMK2G0.50047977
114RPS6KA30.49554648
115DAPK30.48764440
116DYRK20.48112800
117PRKCE0.47123965
118MAPK100.46261789
119RIPK10.46080368
120CDK30.46016784
121BRAF0.44010606
122CAMK2D0.42391167
123PDK40.41191177
124PDK30.41191177
125MAP2K10.41121802
126PRKACA0.40403660
127RPS6KA60.39929137
128FER0.39434207
129PHKG10.39293056
130PHKG20.39293056
131MARK20.39196124
132MAPK110.38936259
133PRKCZ0.37874460
134TEC0.36299716
135CSNK1G20.36012042
136CSNK1A10.35447161
137CAMK40.35402709
138CSNK1D0.34245449
139PRKG10.33019646
140WNK40.32501118
141ROCK20.32190290
142GRK60.31929998
143MUSK0.31846482
144MARK30.31603493
145HIPK20.31143682
146CSNK1G10.29461448
147MAP3K70.29313305

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.77082632
2Nicotine addiction_Homo sapiens_hsa050333.68620216
3GABAergic synapse_Homo sapiens_hsa047272.76827563
4Long-term potentiation_Homo sapiens_hsa047202.71046410
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66638705
6Circadian entrainment_Homo sapiens_hsa047132.62100839
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55066118
8Olfactory transduction_Homo sapiens_hsa047402.51926971
9Glutamatergic synapse_Homo sapiens_hsa047242.48518565
10Amphetamine addiction_Homo sapiens_hsa050312.44626689
11Morphine addiction_Homo sapiens_hsa050322.42094187
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28516845
13Insulin secretion_Homo sapiens_hsa049112.23749420
14Dopaminergic synapse_Homo sapiens_hsa047282.12294944
15Salivary secretion_Homo sapiens_hsa049702.08799715
16Linoleic acid metabolism_Homo sapiens_hsa005912.05878628
17Collecting duct acid secretion_Homo sapiens_hsa049661.93772789
18Selenocompound metabolism_Homo sapiens_hsa004501.93592022
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92766114
20Gastric acid secretion_Homo sapiens_hsa049711.87627003
21Taste transduction_Homo sapiens_hsa047421.83459810
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81285377
23Ether lipid metabolism_Homo sapiens_hsa005651.75456044
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74527981
25Cholinergic synapse_Homo sapiens_hsa047251.70583389
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.68368194
27Long-term depression_Homo sapiens_hsa047301.65460910
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61560545
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59831810
30Oxytocin signaling pathway_Homo sapiens_hsa049211.56897676
31Serotonergic synapse_Homo sapiens_hsa047261.51894169
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.50315149
33Renin secretion_Homo sapiens_hsa049241.49223128
34Regulation of autophagy_Homo sapiens_hsa041401.48428274
35Calcium signaling pathway_Homo sapiens_hsa040201.46259933
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46151566
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45399616
38Cocaine addiction_Homo sapiens_hsa050301.44165626
39Asthma_Homo sapiens_hsa053101.43232160
40GnRH signaling pathway_Homo sapiens_hsa049121.37255621
41Vibrio cholerae infection_Homo sapiens_hsa051101.35222456
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33940966
43Type II diabetes mellitus_Homo sapiens_hsa049301.27759735
44Nitrogen metabolism_Homo sapiens_hsa009101.25942031
45Fanconi anemia pathway_Homo sapiens_hsa034601.25092729
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24416017
47cAMP signaling pathway_Homo sapiens_hsa040241.23245790
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19137260
49Gap junction_Homo sapiens_hsa045401.17304813
50Phototransduction_Homo sapiens_hsa047441.11776405
51Estrogen signaling pathway_Homo sapiens_hsa049151.10829491
52Primary immunodeficiency_Homo sapiens_hsa053401.07716517
53Butanoate metabolism_Homo sapiens_hsa006501.04721408
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04332654
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03299919
56Pancreatic secretion_Homo sapiens_hsa049721.02373597
57ABC transporters_Homo sapiens_hsa020101.02017389
58Glioma_Homo sapiens_hsa052141.01628600
59Basal transcription factors_Homo sapiens_hsa030221.01431899
60ErbB signaling pathway_Homo sapiens_hsa040121.01028235
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00177479
62Cardiac muscle contraction_Homo sapiens_hsa042600.97919646
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97829767
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95402597
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95175179
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94888356
67Parkinsons disease_Homo sapiens_hsa050120.93396307
68Homologous recombination_Homo sapiens_hsa034400.93198676
69Allograft rejection_Homo sapiens_hsa053300.92375038
70Melanogenesis_Homo sapiens_hsa049160.91971692
71Caffeine metabolism_Homo sapiens_hsa002320.91591494
72Autoimmune thyroid disease_Homo sapiens_hsa053200.90497266
73Oocyte meiosis_Homo sapiens_hsa041140.90222397
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88167846
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.84822528
76Type I diabetes mellitus_Homo sapiens_hsa049400.84096936
77Dorso-ventral axis formation_Homo sapiens_hsa043200.83908617
78Graft-versus-host disease_Homo sapiens_hsa053320.80539818
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79671037
80Thyroid hormone synthesis_Homo sapiens_hsa049180.79088493
81Axon guidance_Homo sapiens_hsa043600.77967201
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76145442
83Inositol phosphate metabolism_Homo sapiens_hsa005620.69813082
84RNA polymerase_Homo sapiens_hsa030200.68755911
85Glucagon signaling pathway_Homo sapiens_hsa049220.68677314
86MAPK signaling pathway_Homo sapiens_hsa040100.67357311
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.67354670
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65523147
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65234553
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64304297
91Tryptophan metabolism_Homo sapiens_hsa003800.61420577
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61324118
93RNA degradation_Homo sapiens_hsa030180.60676392
94Circadian rhythm_Homo sapiens_hsa047100.59146735
95Choline metabolism in cancer_Homo sapiens_hsa052310.57443431
96Dilated cardiomyopathy_Homo sapiens_hsa054140.56659991
97mTOR signaling pathway_Homo sapiens_hsa041500.54715502
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54106957
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.53333067
100Protein export_Homo sapiens_hsa030600.53037818
101Huntingtons disease_Homo sapiens_hsa050160.52376285
102VEGF signaling pathway_Homo sapiens_hsa043700.52248506
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51100961
104Ras signaling pathway_Homo sapiens_hsa040140.49093505
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48053549
106One carbon pool by folate_Homo sapiens_hsa006700.47558880
107Endocytosis_Homo sapiens_hsa041440.47479208
108Rap1 signaling pathway_Homo sapiens_hsa040150.46283019
109Bile secretion_Homo sapiens_hsa049760.46220089
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45526066
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.43928489
112Alzheimers disease_Homo sapiens_hsa050100.43768148
113Ovarian steroidogenesis_Homo sapiens_hsa049130.42315505
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42272247
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.42132503
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.42084626
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40964285
118Wnt signaling pathway_Homo sapiens_hsa043100.40229171
119Sulfur relay system_Homo sapiens_hsa041220.40091545
120Alcoholism_Homo sapiens_hsa050340.39778297
121Lysine degradation_Homo sapiens_hsa003100.39399800
122Oxidative phosphorylation_Homo sapiens_hsa001900.39246446
123Arachidonic acid metabolism_Homo sapiens_hsa005900.38489002
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38387272
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37876952
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37359265
127Insulin signaling pathway_Homo sapiens_hsa049100.36688758
128T cell receptor signaling pathway_Homo sapiens_hsa046600.35433895
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34380005
130Prion diseases_Homo sapiens_hsa050200.32245294
131Endometrial cancer_Homo sapiens_hsa052130.31523814
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31463348
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31266737
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29990836
135Glycerolipid metabolism_Homo sapiens_hsa005610.28942063
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28651591
137Non-small cell lung cancer_Homo sapiens_hsa052230.28427717
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28233946
139Renal cell carcinoma_Homo sapiens_hsa052110.25760149
140Chemokine signaling pathway_Homo sapiens_hsa040620.23667950
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23629001
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22893612
143Purine metabolism_Homo sapiens_hsa002300.22324735
144Rheumatoid arthritis_Homo sapiens_hsa053230.21769071

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