KCNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)7.73005608
2rhodopsin mediated signaling pathway (GO:0016056)7.55076639
3retinal cone cell development (GO:0046549)6.77262997
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.91895476
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38286954
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27374545
7synaptic vesicle maturation (GO:0016188)5.23130750
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.11360917
9photoreceptor cell maintenance (GO:0045494)5.01367966
10detection of light stimulus involved in sensory perception (GO:0050962)5.01030947
11detection of light stimulus involved in visual perception (GO:0050908)5.01030947
12regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.00630452
13photoreceptor cell development (GO:0042461)4.99957790
14protein K11-linked deubiquitination (GO:0035871)4.93340417
15eye photoreceptor cell development (GO:0042462)4.77235249
16synaptic vesicle exocytosis (GO:0016079)4.77152214
17protein localization to synapse (GO:0035418)4.73159737
18glutamate secretion (GO:0014047)4.68987048
19detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.55882395
20regulation of synaptic vesicle exocytosis (GO:2000300)4.51099415
21vocalization behavior (GO:0071625)4.49744262
22locomotory exploration behavior (GO:0035641)4.44926025
23phototransduction (GO:0007602)4.42978683
24protein-chromophore linkage (GO:0018298)4.42958557
25phototransduction, visible light (GO:0007603)4.29050365
26detection of light stimulus (GO:0009583)4.24529470
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24235207
28detection of visible light (GO:0009584)4.22579464
29positive regulation of guanylate cyclase activity (GO:0031284)4.20783413
30retinal rod cell development (GO:0046548)4.18178879
31negative regulation of cytosolic calcium ion concentration (GO:0051481)4.17834832
32regulation of glutamate receptor signaling pathway (GO:1900449)4.06005870
33righting reflex (GO:0060013)4.04686561
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.04490977
35regulation of synaptic vesicle transport (GO:1902803)4.02189123
36positive regulation of neurotransmitter transport (GO:0051590)3.87995261
37regulation of voltage-gated calcium channel activity (GO:1901385)3.84652817
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82629565
39neuronal ion channel clustering (GO:0045161)3.80206633
40regulation of guanylate cyclase activity (GO:0031282)3.75117771
41neuronal action potential propagation (GO:0019227)3.72987855
42neurotransmitter secretion (GO:0007269)3.71353299
43synaptic transmission, glutamatergic (GO:0035249)3.69390389
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.65791630
45membrane hyperpolarization (GO:0060081)3.65683035
46visual perception (GO:0007601)3.65544614
47positive regulation of membrane potential (GO:0045838)3.65476407
48neuron cell-cell adhesion (GO:0007158)3.65433487
49neuron-neuron synaptic transmission (GO:0007270)3.65130164
50cellular potassium ion homeostasis (GO:0030007)3.64286713
51regulation of neuronal synaptic plasticity (GO:0048168)3.63067870
52sensory perception of light stimulus (GO:0050953)3.61493342
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60695392
54regulation of postsynaptic membrane potential (GO:0060078)3.60256740
55tooth mineralization (GO:0034505)3.59017596
56serotonin metabolic process (GO:0042428)3.55986182
57response to histamine (GO:0034776)3.51707985
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50362998
59cilium or flagellum-dependent cell motility (GO:0001539)3.42383136
60regulation of neurotransmitter secretion (GO:0046928)3.40995360
61positive regulation of neurotransmitter secretion (GO:0001956)3.39105379
62chemosensory behavior (GO:0007635)3.39001995
63exploration behavior (GO:0035640)3.36950003
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36705447
65glutamate receptor signaling pathway (GO:0007215)3.34402596
66primary amino compound metabolic process (GO:1901160)3.33463220
67neurotransmitter-gated ion channel clustering (GO:0072578)3.32666894
68positive regulation of protein sumoylation (GO:0033235)3.32608921
69postsynaptic membrane organization (GO:0001941)3.30781430
70cAMP biosynthetic process (GO:0006171)3.29792169
71positive regulation of dendritic spine development (GO:0060999)3.29172815
72neurotransmitter transport (GO:0006836)3.27238292
73GMP metabolic process (GO:0046037)3.26493922
74long-term memory (GO:0007616)3.24860949
75regulation of clathrin-mediated endocytosis (GO:2000369)3.24833470
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24741006
77behavioral response to cocaine (GO:0048148)3.23906399
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.23378193
79transmission of nerve impulse (GO:0019226)3.22958619
80sodium ion export (GO:0071436)3.21486739
81regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21222615
82reflex (GO:0060004)3.21004214
83behavioral response to nicotine (GO:0035095)3.20938588
84* potassium ion transmembrane transport (GO:0071805)3.20141862
85* cellular potassium ion transport (GO:0071804)3.20141862
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19456304
87cerebellar Purkinje cell differentiation (GO:0021702)3.18931284
88detection of external stimulus (GO:0009581)3.16782182
89axon ensheathment in central nervous system (GO:0032291)3.15185353
90central nervous system myelination (GO:0022010)3.15185353
91regulation of vesicle fusion (GO:0031338)3.13911799
92detection of chemical stimulus involved in sensory perception (GO:0050907)3.11094745
93detection of abiotic stimulus (GO:0009582)3.10732986
94dendritic spine morphogenesis (GO:0060997)3.09151690
95regulation of synapse structural plasticity (GO:0051823)3.09103868
96long-term synaptic potentiation (GO:0060291)3.08839166
97layer formation in cerebral cortex (GO:0021819)3.07930297
98eye photoreceptor cell differentiation (GO:0001754)3.07605706
99photoreceptor cell differentiation (GO:0046530)3.07605706
100regulation of neurotransmitter transport (GO:0051588)3.05242053
101membrane depolarization during action potential (GO:0086010)3.05053215
102innervation (GO:0060384)3.04603342
103seminiferous tubule development (GO:0072520)3.03912578
104negative regulation of T-helper cell differentiation (GO:0045623)3.03861831
105negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03861831
106gamma-aminobutyric acid transport (GO:0015812)3.03005601
107regulation of synaptic plasticity (GO:0048167)3.02917286
108neuromuscular synaptic transmission (GO:0007274)3.00798156
109cellular response to ATP (GO:0071318)3.00002985
110L-amino acid import (GO:0043092)2.99996750
111membrane depolarization (GO:0051899)2.97929677
112activation of protein kinase A activity (GO:0034199)2.97727506
113synaptic vesicle endocytosis (GO:0048488)2.95509956
114behavioral defense response (GO:0002209)2.95409237
115behavioral fear response (GO:0001662)2.95409237
116startle response (GO:0001964)2.94407067
117neuron recognition (GO:0008038)2.93205365
118neuromuscular process controlling posture (GO:0050884)2.91268774
119cellular response to light stimulus (GO:0071482)2.90980601
120striatum development (GO:0021756)2.90866130
121* potassium ion transport (GO:0006813)2.90646777
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89796997
123dopamine receptor signaling pathway (GO:0007212)2.88098273
124cell communication by electrical coupling (GO:0010644)2.87457599
125regulation of neurotransmitter uptake (GO:0051580)2.87163676
126fear response (GO:0042596)2.86855110
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86736764
128synaptic transmission, dopaminergic (GO:0001963)2.85935007
129behavioral response to ethanol (GO:0048149)2.84016090
130G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.83162185
131proline transport (GO:0015824)2.82344021
132retina layer formation (GO:0010842)2.81981846
133regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.81242149
134regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.81242149
135* synaptic transmission (GO:0007268)2.80854126
136regulation of dendritic spine development (GO:0060998)2.80803935
137dendritic spine organization (GO:0097061)2.79474429
138neural tube formation (GO:0001841)2.79401309
139regulation of synaptic transmission, glutamatergic (GO:0051966)2.78948232
140cAMP metabolic process (GO:0046058)2.78946052
141response to auditory stimulus (GO:0010996)2.75488775
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75445501
143neuronal action potential (GO:0019228)2.72399056
144indole-containing compound metabolic process (GO:0042430)2.70862947
145auditory behavior (GO:0031223)2.68314235
146enteric nervous system development (GO:0048484)2.65519503
147regulation of neurotransmitter levels (GO:0001505)2.60262709
148phosphorelay signal transduction system (GO:0000160)2.60115805
149response to dietary excess (GO:0002021)2.59881529
150phosphatidylinositol acyl-chain remodeling (GO:0036149)2.59803725
151positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59671063
152regulation of cell communication by electrical coupling (GO:0010649)2.57073360
153indolalkylamine catabolic process (GO:0046218)2.56899010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24493433
2GBX2_23144817_ChIP-Seq_PC3_Human3.75301582
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91107072
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80634671
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68800123
6* DROSHA_22980978_ChIP-Seq_HELA_Human2.54872970
7REST_21632747_ChIP-Seq_MESCs_Mouse2.54734885
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.52271319
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50993970
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50993970
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47788214
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42450207
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39372235
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38573732
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36686559
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27315557
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.24659851
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17983106
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.08391614
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08074623
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06473393
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98948555
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.97391860
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.97108756
25AR_21572438_ChIP-Seq_LNCaP_Human1.92072193
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85504417
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81939842
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79498898
29SMAD4_21799915_ChIP-Seq_A2780_Human1.76353689
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71517217
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70331908
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69715196
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67706939
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65530871
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62354748
36TP53_16413492_ChIP-PET_HCT116_Human1.60195926
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54678359
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54089485
39TAF15_26573619_Chip-Seq_HEK293_Human1.47869348
40P300_19829295_ChIP-Seq_ESCs_Human1.41334148
41ER_23166858_ChIP-Seq_MCF-7_Human1.41177519
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.37756080
43AR_19668381_ChIP-Seq_PC3_Human1.34896734
44* STAT3_23295773_ChIP-Seq_U87_Human1.34125877
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.33684183
46VDR_22108803_ChIP-Seq_LS180_Human1.33257297
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.31669387
48RNF2_27304074_Chip-Seq_NSC_Mouse1.30861876
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30334194
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28673936
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27681724
52CBP_20019798_ChIP-Seq_JUKART_Human1.26197572
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26197572
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.25997072
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25832165
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25649021
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25453868
58CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23432427
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23290066
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22154298
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21113043
62FUS_26573619_Chip-Seq_HEK293_Human1.21021612
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.19796842
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19158877
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18818471
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18552376
67ZNF274_21170338_ChIP-Seq_K562_Hela1.18494510
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18433478
69AR_25329375_ChIP-Seq_VCAP_Human1.17475348
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.16558113
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16165544
72TCF4_23295773_ChIP-Seq_U87_Human1.15634438
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15260245
74* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14709161
75* NANOG_18555785_Chip-Seq_ESCs_Mouse1.14612085
76* SMAD3_21741376_ChIP-Seq_HESCs_Human1.14490324
77IGF1R_20145208_ChIP-Seq_DFB_Human1.14282874
78AHR_22903824_ChIP-Seq_MCF-7_Human1.13876572
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12920911
80KDM2B_26808549_Chip-Seq_K562_Human1.12600507
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12523249
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12026388
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.12011833
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.11778188
85RXR_22108803_ChIP-Seq_LS180_Human1.11247456
86TCF4_22108803_ChIP-Seq_LS180_Human1.10161034
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09675563
88* RING1B_27294783_Chip-Seq_NPCs_Mouse1.09261696
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09078492
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08753373
91KDM2B_26808549_Chip-Seq_REH_Human1.08734664
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.08710519
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.07705165
94BCAT_22108803_ChIP-Seq_LS180_Human1.07174057
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05877230
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05430121
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.04611277
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04318943
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04276008
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04263361
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03075575
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02666446
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.01670720
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00778168
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00397714
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00175009
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00040234
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99779721
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99671650
110P53_22387025_ChIP-Seq_ESCs_Mouse0.98757168
111* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98294828
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97767370
113RUNX2_22187159_ChIP-Seq_PCA_Human0.96567770
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.95896298
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95639054
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94591521
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94591521
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94569200
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92861031
120* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91466348
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90928929
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90833401
123* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89825536
124CTCF_27219007_Chip-Seq_Bcells_Human0.89704297
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88561905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.33271927
2MP0004859_abnormal_synaptic_plasticity5.09649614
3MP0003011_delayed_dark_adaptation4.66301061
4MP0003880_abnormal_central_pattern4.05460272
5MP0005253_abnormal_eye_physiology3.50302204
6MP0004270_analgesia3.47534860
7MP0003635_abnormal_synaptic_transmissio3.33769244
8MP0006072_abnormal_retinal_apoptosis3.30065699
9MP0005423_abnormal_somatic_nervous3.06296919
10MP0005084_abnormal_gallbladder_morpholo2.97986829
11MP0009745_abnormal_behavioral_response2.76732949
12MP0001968_abnormal_touch/_nociception2.71130924
13MP0002063_abnormal_learning/memory/cond2.68068027
14MP0002064_seizures2.61641747
15MP0002822_catalepsy2.55366394
16MP0009046_muscle_twitch2.51846005
17MP0001486_abnormal_startle_reflex2.36858068
18MP0002734_abnormal_mechanical_nocicepti2.35219610
19MP0002272_abnormal_nervous_system2.34025934
20MP0002572_abnormal_emotion/affect_behav2.32787816
21MP0002090_abnormal_vision2.05407708
22MP0002229_neurodegeneration2.00205145
23MP0005195_abnormal_posterior_eye1.94567319
24MP0002735_abnormal_chemical_nociception1.86554826
25MP0002736_abnormal_nociception_after1.86424852
26MP0009780_abnormal_chondrocyte_physiolo1.81997487
27MP0002638_abnormal_pupillary_reflex1.76705633
28MP0001501_abnormal_sleep_pattern1.75912566
29MP0002067_abnormal_sensory_capabilities1.70285579
30MP0001984_abnormal_olfaction1.69931859
31MP0002882_abnormal_neuron_morphology1.66321057
32MP0001970_abnormal_pain_threshold1.59218661
33MP0001324_abnormal_eye_pigmentation1.56020937
34MP0002909_abnormal_adrenal_gland1.54742060
35MP0004924_abnormal_behavior1.54732794
36MP0005386_behavior/neurological_phenoty1.54732794
37MP0002733_abnormal_thermal_nociception1.53403740
38MP0001440_abnormal_grooming_behavior1.52550769
39MP0008569_lethality_at_weaning1.49318122
40MP0001502_abnormal_circadian_rhythm1.44507666
41MP0003195_calcinosis1.44164989
42MP0001485_abnormal_pinna_reflex1.43433416
43MP0005646_abnormal_pituitary_gland1.43109821
44MP0002752_abnormal_somatic_nervous1.42849667
45MP0002837_dystrophic_cardiac_calcinosis1.42370662
46MP0005391_vision/eye_phenotype1.38175518
47MP0002184_abnormal_innervation1.35941733
48MP0003950_abnormal_plasma_membrane1.35171448
49MP0004133_heterotaxia1.34913508
50MP0004811_abnormal_neuron_physiology1.32053011
51MP0002557_abnormal_social/conspecific_i1.31005244
52MP0003879_abnormal_hair_cell1.30074517
53MP0006276_abnormal_autonomic_nervous1.28977487
54MP0001986_abnormal_taste_sensitivity1.27752084
55MP0002928_abnormal_bile_duct1.26710097
56MP0000751_myopathy1.26588453
57MP0004233_abnormal_muscle_weight1.26083460
58MP0000778_abnormal_nervous_system1.22532344
59MP0004215_abnormal_myocardial_fiber1.21112163
60MP0004145_abnormal_muscle_electrophysio1.21111667
61MP0004885_abnormal_endolymph1.20703579
62MP0005448_abnormal_energy_balance1.18705636
63MP0003329_amyloid_beta_deposits1.17947493
64MP0004858_abnormal_nervous_system1.16270919
65MP0002066_abnormal_motor_capabilities/c1.12673758
66MP0008877_abnormal_DNA_methylation1.11530652
67MP0004147_increased_porphyrin_level1.09755756
68MP0003633_abnormal_nervous_system1.09558703
69MP0000955_abnormal_spinal_cord1.06823145
70MP0003252_abnormal_bile_duct1.06598918
71MP0004085_abnormal_heartbeat1.00325765
72MP0005167_abnormal_blood-brain_barrier1.00259541
73MP0003787_abnormal_imprinting0.99855298
74MP0010386_abnormal_urinary_bladder0.97478904
75MP0001905_abnormal_dopamine_level0.95314513
76MP0001529_abnormal_vocalization0.95229180
77MP0003646_muscle_fatigue0.91749811
78MP0003690_abnormal_glial_cell0.91740161
79MP0002653_abnormal_ependyma_morphology0.90397080
80MP0005645_abnormal_hypothalamus_physiol0.89376604
81MP0003632_abnormal_nervous_system0.88701844
82MP0001188_hyperpigmentation0.88513363
83MP0003631_nervous_system_phenotype0.86186501
84MP0004142_abnormal_muscle_tone0.86151231
85MP0003634_abnormal_glial_cell0.84658548
86MP0002152_abnormal_brain_morphology0.83485600
87MP0008872_abnormal_physiological_respon0.82981561
88MP0001963_abnormal_hearing_physiology0.80965564
89MP0003136_yellow_coat_color0.80671319
90MP0000920_abnormal_myelination0.80245132
91MP0005394_taste/olfaction_phenotype0.79799623
92MP0005499_abnormal_olfactory_system0.79799623
93MP0000013_abnormal_adipose_tissue0.77953195
94MP0008961_abnormal_basal_metabolism0.77085576
95MP0002102_abnormal_ear_morphology0.77021353
96MP0005535_abnormal_body_temperature0.75767795
97MP0005174_abnormal_tail_pigmentation0.73539346
98MP0002069_abnormal_eating/drinking_beha0.73292745
99MP0004742_abnormal_vestibular_system0.72691649
100MP0008874_decreased_physiological_sensi0.71109535
101MP0005620_abnormal_muscle_contractility0.70419011
102MP0005670_abnormal_white_adipose0.69292638
103MP0004036_abnormal_muscle_relaxation0.67570681
104MP0004484_altered_response_of0.67500143
105MP0003137_abnormal_impulse_conducting0.67198811
106MP0002751_abnormal_autonomic_nervous0.66541522
107MP0000631_abnormal_neuroendocrine_gland0.64713835
108MP0000230_abnormal_systemic_arterial0.64163096
109MP0003122_maternal_imprinting0.63627863
110MP0001177_atelectasis0.62875775
111MP0000427_abnormal_hair_cycle0.61909909
112MP0008875_abnormal_xenobiotic_pharmacok0.61663694
113MP0004043_abnormal_pH_regulation0.61532588
114MP0005187_abnormal_penis_morphology0.61455073
115MP0005171_absent_coat_pigmentation0.60476553
116MP0000749_muscle_degeneration0.59727124
117MP0000569_abnormal_digit_pigmentation0.59540895
118MP0003283_abnormal_digestive_organ0.59424362
119MP0001664_abnormal_digestion0.58892262
120MP0000026_abnormal_inner_ear0.58563878
121MP0002332_abnormal_exercise_endurance0.58548214
122MP0002876_abnormal_thyroid_physiology0.58547229
123MP0004130_abnormal_muscle_cell0.58290893
124MP0003045_fibrosis0.57382513

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.53843271
2Bony spicule pigmentary retinopathy (HP:0007737)8.07811713
3Central scotoma (HP:0000603)7.41508490
4Absent rod-and cone-mediated responses on ERG (HP:0007688)6.68110749
5Dyschromatopsia (HP:0007641)6.62826939
6Abnormality of macular pigmentation (HP:0008002)6.53165790
7Abnormal rod and cone electroretinograms (HP:0008323)6.43171991
8Scotoma (HP:0000575)6.23672204
9Focal motor seizures (HP:0011153)5.60557271
10Pigmentary retinal degeneration (HP:0001146)5.40680224
11Attenuation of retinal blood vessels (HP:0007843)5.17273392
12Chorioretinal atrophy (HP:0000533)4.89903369
13Decreased central vision (HP:0007663)4.67794962
14Pendular nystagmus (HP:0012043)4.63246864
15Myokymia (HP:0002411)4.53974656
16Abolished electroretinogram (ERG) (HP:0000550)4.29373248
17Focal seizures (HP:0007359)4.05258107
18Epileptic encephalopathy (HP:0200134)4.04481298
19Photophobia (HP:0000613)3.97410437
20Type II diabetes mellitus (HP:0005978)3.95182413
21Amelogenesis imperfecta (HP:0000705)3.89176074
22Febrile seizures (HP:0002373)3.86442018
23Choroideremia (HP:0001139)3.80295176
24Visual hallucinations (HP:0002367)3.75132386
25Abnormality of binocular vision (HP:0011514)3.64932400
26Diplopia (HP:0000651)3.64932400
27Severe visual impairment (HP:0001141)3.49109313
28Macular degeneration (HP:0000608)3.48291130
29Posterior subcapsular cataract (HP:0007787)3.42727499
30Abnormality of midbrain morphology (HP:0002418)3.35258588
31Molar tooth sign on MRI (HP:0002419)3.35258588
32Progressive cerebellar ataxia (HP:0002073)3.28963677
33Polyuria (HP:0000103)3.25732478
34Retinitis pigmentosa (HP:0000510)3.18004238
35Overgrowth (HP:0001548)3.16295942
36Cone-rod dystrophy (HP:0000548)3.14388019
37Constricted visual fields (HP:0001133)3.12896829
38Decreased electroretinogram (ERG) amplitude (HP:0000654)3.10692489
39Atonic seizures (HP:0010819)3.10351981
40Protruding tongue (HP:0010808)3.09101170
41Inability to walk (HP:0002540)3.04554404
42Increased corneal curvature (HP:0100692)3.02486983
43Keratoconus (HP:0000563)3.02486983
44Nephronophthisis (HP:0000090)2.86923346
45Pancreatic cysts (HP:0001737)2.86317136
46Absence seizures (HP:0002121)2.85942791
47Broad-based gait (HP:0002136)2.84737762
48Clumsiness (HP:0002312)2.84640104
49Vitreoretinal degeneration (HP:0000655)2.82308455
50Dysdiadochokinesis (HP:0002075)2.79151966
51Hyperventilation (HP:0002883)2.74870689
52Generalized tonic-clonic seizures (HP:0002069)2.74380019
53Gaze-evoked nystagmus (HP:0000640)2.73646395
54Abnormal urine output (HP:0012590)2.68105053
55Action tremor (HP:0002345)2.65343416
56Hemiplegia (HP:0002301)2.60895175
57Dialeptic seizures (HP:0011146)2.59884725
58Truncal ataxia (HP:0002078)2.57810736
59Abnormality of the renal medulla (HP:0100957)2.55873191
60Pancreatic fibrosis (HP:0100732)2.53779686
61Retinal atrophy (HP:0001105)2.53592661
62Poor eye contact (HP:0000817)2.46490756
63Gait imbalance (HP:0002141)2.45191860
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43992112
65True hermaphroditism (HP:0010459)2.40750341
66Abnormality of dental color (HP:0011073)2.39138072
67Genetic anticipation (HP:0003743)2.35409360
68Limb dystonia (HP:0002451)2.35270262
69Progressive visual loss (HP:0000529)2.32740657
70Urinary bladder sphincter dysfunction (HP:0002839)2.32653067
71Widely spaced teeth (HP:0000687)2.30730443
72Fair hair (HP:0002286)2.28923866
73Congenital primary aphakia (HP:0007707)2.28125853
74Depression (HP:0000716)2.27531856
75Abnormality of calcium-phosphate metabolism (HP:0100530)2.26531274
76Impaired social interactions (HP:0000735)2.25876781
77Abnormal social behavior (HP:0012433)2.25876781
78Abnormality of renal excretion (HP:0011036)2.22958559
79Abnormal drinking behavior (HP:0030082)2.20639747
80Polydipsia (HP:0001959)2.20639747
81Decreased circulating renin level (HP:0003351)2.19830050
82Status epilepticus (HP:0002133)2.18630073
83Subcapsular cataract (HP:0000523)2.16408140
84Amblyopia (HP:0000646)2.15421892
85Optic disc pallor (HP:0000543)2.13484601
86Supranuclear gaze palsy (HP:0000605)2.12514723
87Dysmetric saccades (HP:0000641)2.11320350
88Congenital sensorineural hearing impairment (HP:0008527)2.10152887
89Dysmetria (HP:0001310)2.10009835
90Chronic hepatic failure (HP:0100626)2.08796798
91Impaired vibration sensation in the lower limbs (HP:0002166)2.08704304
92Horizontal nystagmus (HP:0000666)2.08570791
93Anxiety (HP:0000739)2.06474853
94Cystic liver disease (HP:0006706)2.06023275
95Impaired smooth pursuit (HP:0007772)2.04552179
96Progressive inability to walk (HP:0002505)2.02955630
97Nephrogenic diabetes insipidus (HP:0009806)2.01559876
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.00589943
99Medial flaring of the eyebrow (HP:0010747)1.99659241
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99582889
101Prolonged QT interval (HP:0001657)1.99491899
102Generalized hypopigmentation of hair (HP:0011358)1.97639553
103Postural instability (HP:0002172)1.97553005
104Scanning speech (HP:0002168)1.93026912
105Volvulus (HP:0002580)1.92884583
106Ankle clonus (HP:0011448)1.89648110
107Drooling (HP:0002307)1.89631299
108Excessive salivation (HP:0003781)1.89631299
109Abnormal EKG (HP:0003115)1.89428041
110Syncope (HP:0001279)1.89118499
111Abnormality of the renal cortex (HP:0011035)1.88951904
112Type II lissencephaly (HP:0007260)1.86515913
113Fetal akinesia sequence (HP:0001989)1.86260636
114Epileptiform EEG discharges (HP:0011182)1.85219908
115Pheochromocytoma (HP:0002666)1.83917543
116Absent speech (HP:0001344)1.83243456
117Wide nasal bridge (HP:0000431)1.82856574
118Tachypnea (HP:0002789)1.80666702
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.79070088
120Abnormality of ocular smooth pursuit (HP:0000617)1.77951058
121Ventricular fibrillation (HP:0001663)1.75367911
122EEG with generalized epileptiform discharges (HP:0011198)1.74232568
123Abnormality of the dental pulp (HP:0006479)1.73089230
124Abnormal respiratory motile cilium physiology (HP:0012261)1.72830492
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70621850
126Abnormality of alanine metabolism (HP:0010916)1.70621850
127Hyperalaninemia (HP:0003348)1.70621850
128Bradykinesia (HP:0002067)1.69783127
129Poor coordination (HP:0002370)1.69415555
130Genital tract atresia (HP:0001827)1.68675231
131Vaginal atresia (HP:0000148)1.68349013
132Dyskinesia (HP:0100660)1.68259316
133Spastic gait (HP:0002064)1.64961010
134Abnormality of salivation (HP:0100755)1.63563582
135Abnormality of renin-angiotensin system (HP:0000847)1.63549703
136Polyphagia (HP:0002591)1.63113655
137Abnormality of the lower motor neuron (HP:0002366)1.61601017
138Hypsarrhythmia (HP:0002521)1.61180255
139Hemiparesis (HP:0001269)1.59648683
140Impaired vibratory sensation (HP:0002495)1.59421464
141Specific learning disability (HP:0001328)1.59105976
142Stereotypic behavior (HP:0000733)1.58467030
143Abnormal eating behavior (HP:0100738)1.56857141
144Urinary urgency (HP:0000012)1.55291593
145Intention tremor (HP:0002080)1.54939487
146Neuroendocrine neoplasm (HP:0100634)1.54596485
147Generalized myoclonic seizures (HP:0002123)1.54289053
148Torticollis (HP:0000473)1.51417326
149Papilledema (HP:0001085)1.49661497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.15296075
2EPHA44.72052549
3NTRK34.34267489
4GRK13.24012696
5MAP3K93.13649186
6MAP3K43.08746121
7MAP2K72.46881303
8DAPK22.46783948
9PRKD32.19158185
10MINK12.16934977
11ACVR1B2.12274327
12MARK12.10342408
13PAK62.10264952
14CASK2.04367990
15BMPR1B2.04234379
16RIPK41.87280255
17MAP2K41.84589637
18CAMKK11.78264754
19SIK21.77937839
20ADRBK21.72502322
21KSR21.70517883
22NTRK11.64877589
23PINK11.59372723
24NTRK21.53042809
25PNCK1.50216818
26CDK51.49278147
27STK381.47647941
28DAPK11.46955216
29GRK51.44633289
30PLK21.44104417
31MAP3K121.33350163
32FES1.33124085
33KSR11.24868520
34BLK1.24173109
35PRPF4B1.17914407
36SGK2231.15998508
37SGK4941.15998508
38SGK21.15027340
39MAPK131.11674509
40CAMK1G1.11495511
41PRKCG1.11400849
42WNK31.10249194
43MAP3K21.10170703
44TNIK1.10142301
45STK31.05358971
46CDK191.04375473
47PHKG11.02972779
48PHKG21.02972779
49PRKCH1.02758990
50CAMK2A1.02022993
51OBSCN1.00706104
52CAMK10.98618386
53WNK40.97845103
54SGK30.95868160
55AKT30.92514571
56CAMKK20.91510852
57STK390.90202910
58STK110.86115175
59BMPR20.84006367
60SGK10.83609591
61INSRR0.83274916
62ARAF0.82969200
63CAMK2D0.82936279
64PIK3CA0.81602894
65UHMK10.79398262
66TAOK10.79142391
67RET0.79137766
68MAP4K20.78328460
69MAPK120.78003968
70MAP3K130.76990744
71LMTK20.75069467
72PTK2B0.74756281
73CAMK2B0.74580091
74PKN10.74358377
75TLK10.72540787
76ADRBK10.71958379
77MKNK20.71411670
78WNK10.69523182
79CDK180.68315816
80MAPK70.67772279
81PRKAA10.66493290
82CDK150.66323718
83MAP2K60.65471119
84PDK10.65191981
85CCNB10.64925864
86STK38L0.64383500
87DYRK1A0.62442599
88CDC42BPA0.62214742
89PAK30.62168982
90CDK140.61851945
91MAP4K10.61770956
92FGFR20.61474640
93TAOK30.61152628
94PDPK10.60535593
95RPS6KA30.60534610
96PRKCZ0.60263303
97MUSK0.59800821
98TYRO30.57993891
99TNK20.57382453
100MARK20.56703284
101CAMK40.56157461
102CDK11A0.55932985
103ZAK0.55226966
104MAP3K10.55033441
105PRKCE0.54484712
106FER0.54004035
107MAP3K70.53505064
108OXSR10.52827106
109NUAK10.52167163
110PRKCB0.51174447
111PIK3CG0.50709698
112RAF10.49227097
113MAPK100.48639002
114MAP3K60.46864120
115SIK30.46698192
116MAPKAPK50.46550341
117CAMK1D0.46386036
118PRKAA20.46312106
119ERBB20.44676798
120PRKG10.44296287
121CSNK1G20.43427006
122NEK60.42944274
123PRKD20.42914584
124NME10.42790096
125PRKCA0.42733093
126TXK0.42585762
127HIPK20.41209872
128CAMK2G0.40523428
129MAPK150.39914387
130PRKACA0.38733874
131ALK0.38645040
132LATS20.38274849
133CSNK1A10.37077811
134CSNK1D0.36941824
135PRKCQ0.36923146

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047448.49546581
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04949301
3Nicotine addiction_Homo sapiens_hsa050332.78558892
4Olfactory transduction_Homo sapiens_hsa047402.76116231
5GABAergic synapse_Homo sapiens_hsa047272.36376429
6Circadian entrainment_Homo sapiens_hsa047132.34414642
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28297189
8Glutamatergic synapse_Homo sapiens_hsa047242.21660922
9Morphine addiction_Homo sapiens_hsa050322.17629300
10Long-term potentiation_Homo sapiens_hsa047202.13006910
11Amphetamine addiction_Homo sapiens_hsa050311.98804816
12Insulin secretion_Homo sapiens_hsa049111.94009036
13Dopaminergic synapse_Homo sapiens_hsa047281.93974362
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83359679
15Linoleic acid metabolism_Homo sapiens_hsa005911.83278332
16Cholinergic synapse_Homo sapiens_hsa047251.82540556
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81071101
18Salivary secretion_Homo sapiens_hsa049701.74552097
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57794836
20Gastric acid secretion_Homo sapiens_hsa049711.53315994
21Serotonergic synapse_Homo sapiens_hsa047261.52094433
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49811745
23Renin secretion_Homo sapiens_hsa049241.47994201
24Oxytocin signaling pathway_Homo sapiens_hsa049211.47792029
25Taste transduction_Homo sapiens_hsa047421.42478510
26Cocaine addiction_Homo sapiens_hsa050301.40287284
27Calcium signaling pathway_Homo sapiens_hsa040201.33706662
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23084299
29Ether lipid metabolism_Homo sapiens_hsa005651.22539310
30cAMP signaling pathway_Homo sapiens_hsa040241.17587337
31Long-term depression_Homo sapiens_hsa047301.17232543
32GnRH signaling pathway_Homo sapiens_hsa049121.15408512
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14452941
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11539236
35Cardiac muscle contraction_Homo sapiens_hsa042601.10110780
36Type II diabetes mellitus_Homo sapiens_hsa049301.09697713
37Collecting duct acid secretion_Homo sapiens_hsa049661.09062961
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08902961
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03706127
40ABC transporters_Homo sapiens_hsa020101.03558329
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02271677
42Butanoate metabolism_Homo sapiens_hsa006501.02218859
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97903707
44Dilated cardiomyopathy_Homo sapiens_hsa054140.93564870
45Gap junction_Homo sapiens_hsa045400.92003929
46Circadian rhythm_Homo sapiens_hsa047100.88303708
47Glioma_Homo sapiens_hsa052140.83073152
48Nitrogen metabolism_Homo sapiens_hsa009100.82196645
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.80510731
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79834016
51Estrogen signaling pathway_Homo sapiens_hsa049150.79435915
52Tryptophan metabolism_Homo sapiens_hsa003800.78079945
53Pancreatic secretion_Homo sapiens_hsa049720.75520419
54Histidine metabolism_Homo sapiens_hsa003400.75364472
55Melanogenesis_Homo sapiens_hsa049160.75022808
56ErbB signaling pathway_Homo sapiens_hsa040120.73640300
57Vibrio cholerae infection_Homo sapiens_hsa051100.67378467
58Axon guidance_Homo sapiens_hsa043600.66440781
59Glucagon signaling pathway_Homo sapiens_hsa049220.65018656
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63534481
61Thyroid hormone synthesis_Homo sapiens_hsa049180.62128768
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.62083490
63Dorso-ventral axis formation_Homo sapiens_hsa043200.61897076
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61659238
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61088119
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60920686
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60765699
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59058788
69Sulfur relay system_Homo sapiens_hsa041220.57734529
70MAPK signaling pathway_Homo sapiens_hsa040100.57666344
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57360639
72Choline metabolism in cancer_Homo sapiens_hsa052310.55012650
73Arachidonic acid metabolism_Homo sapiens_hsa005900.54480949
74Oocyte meiosis_Homo sapiens_hsa041140.54285441
75mTOR signaling pathway_Homo sapiens_hsa041500.53086525
76Platelet activation_Homo sapiens_hsa046110.51038528
77Inositol phosphate metabolism_Homo sapiens_hsa005620.50964424
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.50800683
79beta-Alanine metabolism_Homo sapiens_hsa004100.50069173
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.46479346
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46192751
82Ras signaling pathway_Homo sapiens_hsa040140.45421291
83Fatty acid biosynthesis_Homo sapiens_hsa000610.44967536
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44016608
85Fat digestion and absorption_Homo sapiens_hsa049750.43741385
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42842524
87VEGF signaling pathway_Homo sapiens_hsa043700.42720155
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41659690
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41030926
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40082996
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.39198573
92Insulin signaling pathway_Homo sapiens_hsa049100.38589809
93Bile secretion_Homo sapiens_hsa049760.38356493
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.36415449
95Alcoholism_Homo sapiens_hsa050340.35664929
96Caffeine metabolism_Homo sapiens_hsa002320.35045523
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.34310396
98Rap1 signaling pathway_Homo sapiens_hsa040150.33653936
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32938457
100Retinol metabolism_Homo sapiens_hsa008300.31350627
101Type I diabetes mellitus_Homo sapiens_hsa049400.31260699
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30900612
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30498091
104Ovarian steroidogenesis_Homo sapiens_hsa049130.30497531
105Wnt signaling pathway_Homo sapiens_hsa043100.30441094
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28564270
107Mineral absorption_Homo sapiens_hsa049780.28506987
108Alzheimers disease_Homo sapiens_hsa050100.27788762
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27755778
110Non-small cell lung cancer_Homo sapiens_hsa052230.26969130
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26926047
112Chemical carcinogenesis_Homo sapiens_hsa052040.26882776
113Endocytosis_Homo sapiens_hsa041440.26443306
114Sulfur metabolism_Homo sapiens_hsa009200.26269129
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.26196257
116Chemokine signaling pathway_Homo sapiens_hsa040620.25800587
117Lysine degradation_Homo sapiens_hsa003100.25728559
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25315469
119Endometrial cancer_Homo sapiens_hsa052130.24160734
120Renal cell carcinoma_Homo sapiens_hsa052110.23974917
121Regulation of autophagy_Homo sapiens_hsa041400.23498111
122African trypanosomiasis_Homo sapiens_hsa051430.23055201
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22737776
124Glycerolipid metabolism_Homo sapiens_hsa005610.21178822
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20770092
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20590647
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.20167002
128AMPK signaling pathway_Homo sapiens_hsa041520.18828314

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