KCNB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.23020725
2synaptic vesicle exocytosis (GO:0016079)4.98133104
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.94146472
4vocalization behavior (GO:0071625)4.89262179
5gamma-aminobutyric acid transport (GO:0015812)4.51638843
6protein localization to synapse (GO:0035418)4.51051083
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35644705
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29253455
9regulation of synaptic vesicle exocytosis (GO:2000300)4.25845558
10glutamate secretion (GO:0014047)4.25298312
11presynaptic membrane assembly (GO:0097105)4.23115384
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.20351859
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17665607
14neuronal action potential propagation (GO:0019227)4.15374589
15pyrimidine nucleobase catabolic process (GO:0006208)4.04079798
16behavioral response to nicotine (GO:0035095)4.02431114
17negative regulation of dendrite morphogenesis (GO:0050774)4.01148812
18glutamate receptor signaling pathway (GO:0007215)4.00410201
19regulation of glutamate receptor signaling pathway (GO:1900449)3.96790017
20presynaptic membrane organization (GO:0097090)3.91543912
21innervation (GO:0060384)3.91531432
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.91387089
23synaptic vesicle maturation (GO:0016188)3.89944597
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80161824
25membrane depolarization during action potential (GO:0086010)3.75871382
26neuron recognition (GO:0008038)3.74695277
27regulation of synaptic vesicle transport (GO:1902803)3.74257494
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70576249
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69629328
30neuron-neuron synaptic transmission (GO:0007270)3.67914919
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.67905787
32neurotransmitter secretion (GO:0007269)3.65056102
33neuromuscular synaptic transmission (GO:0007274)3.64742118
34postsynaptic membrane organization (GO:0001941)3.64093057
35synaptic transmission, glutamatergic (GO:0035249)3.63040671
36neurofilament cytoskeleton organization (GO:0060052)3.58812329
37cell migration in hindbrain (GO:0021535)3.56917060
38exploration behavior (GO:0035640)3.56333006
39central nervous system projection neuron axonogenesis (GO:0021952)3.56110651
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.54933841
41negative regulation of dendrite development (GO:2000171)3.51957297
42locomotory exploration behavior (GO:0035641)3.51871572
43nucleobase catabolic process (GO:0046113)3.50854786
44positive regulation of synapse maturation (GO:0090129)3.48067536
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.47475584
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46616712
47cerebellar Purkinje cell differentiation (GO:0021702)3.46000419
48neuronal action potential (GO:0019228)3.45478423
49axonal fasciculation (GO:0007413)3.45075051
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43698943
51synaptic vesicle endocytosis (GO:0048488)3.40782092
52central nervous system neuron axonogenesis (GO:0021955)3.40535397
53negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.40084195
54neurotransmitter-gated ion channel clustering (GO:0072578)3.37996915
55proline transport (GO:0015824)3.36503615
56synapse assembly (GO:0007416)3.35389408
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.27481948
58reflex (GO:0060004)3.25422481
59regulation of neuronal synaptic plasticity (GO:0048168)3.21238601
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20195059
61righting reflex (GO:0060013)3.19334145
62auditory behavior (GO:0031223)3.18138069
63regulation of postsynaptic membrane potential (GO:0060078)3.18029393
64startle response (GO:0001964)3.17841560
65sympathetic nervous system development (GO:0048485)3.17489764
66neurotransmitter transport (GO:0006836)3.17036730
67neural tube formation (GO:0001841)3.15750805
68urinary tract smooth muscle contraction (GO:0014848)3.13692821
69transmission of nerve impulse (GO:0019226)3.13331353
70response to histamine (GO:0034776)3.10914667
71brain morphogenesis (GO:0048854)3.10589788
72membrane depolarization (GO:0051899)3.10560091
73cellular potassium ion homeostasis (GO:0030007)3.09860908
74spinal cord motor neuron differentiation (GO:0021522)3.08669436
75regulation of neurotransmitter secretion (GO:0046928)3.08315274
76regulation of vesicle fusion (GO:0031338)3.07726835
77adult walking behavior (GO:0007628)3.07545848
78response to pheromone (GO:0019236)3.04716958
79serotonin metabolic process (GO:0042428)3.04142536
80long-term synaptic potentiation (GO:0060291)3.03244894
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02144892
82regulation of synapse maturation (GO:0090128)3.01969069
83behavioral fear response (GO:0001662)3.01557987
84behavioral defense response (GO:0002209)3.01557987
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00972674
86response to auditory stimulus (GO:0010996)3.00902613
87detection of temperature stimulus (GO:0016048)3.00524972
88long-term memory (GO:0007616)3.00399881
89glycerophospholipid catabolic process (GO:0046475)3.00366362
90detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.97523440
91detection of temperature stimulus involved in sensory perception (GO:0050961)2.97523440
92membrane hyperpolarization (GO:0060081)2.97495956
93regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95828788
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94496876
95positive regulation of synapse assembly (GO:0051965)2.93790148
96detection of calcium ion (GO:0005513)2.92583433
97neuronal ion channel clustering (GO:0045161)2.92516394
98regulation of synapse structural plasticity (GO:0051823)2.92301762
99layer formation in cerebral cortex (GO:0021819)2.91986307
100retinal cone cell development (GO:0046549)2.90921190
101positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90818825
102* synaptic transmission (GO:0007268)2.89485997
103fear response (GO:0042596)2.88743987
104dendritic spine morphogenesis (GO:0060997)2.87756144
105synaptic vesicle transport (GO:0048489)2.87199258
106establishment of synaptic vesicle localization (GO:0097480)2.87199258
107positive regulation of membrane potential (GO:0045838)2.86886835
108positive regulation of potassium ion transmembrane transport (GO:1901381)2.86645518
109regulation of synaptic transmission, GABAergic (GO:0032228)2.85776841
110neuron fate specification (GO:0048665)2.85556160
111cerebellar granule cell differentiation (GO:0021707)2.85038439
112learning (GO:0007612)2.84259846
113regulation of synaptic plasticity (GO:0048167)2.83965459
114striatum development (GO:0021756)2.82799491
115negative regulation of hormone biosynthetic process (GO:0032353)2.82760395
116behavioral response to ethanol (GO:0048149)2.81323304
117regulation of action potential (GO:0098900)2.81299234
118regulation of neurotransmitter transport (GO:0051588)2.80909407
119serotonin receptor signaling pathway (GO:0007210)2.78864981
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.78628477
121cochlea development (GO:0090102)2.78246873
122dendrite morphogenesis (GO:0048813)2.77022189
123regulation of synapse assembly (GO:0051963)2.75996587
124regulation of neurotransmitter levels (GO:0001505)2.75837471
125chemosensory behavior (GO:0007635)2.75797122
126calcium ion import (GO:0070509)2.75357601
127cerebellum development (GO:0021549)2.74140921
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73859336
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.72753534
130adult behavior (GO:0030534)2.72694954
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71323348
132limb bud formation (GO:0060174)2.70858100
133retinal ganglion cell axon guidance (GO:0031290)2.70076781
134histone H3-K4 trimethylation (GO:0080182)2.67091373
135dendrite development (GO:0016358)2.64896645
136synaptic transmission, cholinergic (GO:0007271)2.64058209
137primary amino compound metabolic process (GO:1901160)2.63705991
138atrial cardiac muscle cell action potential (GO:0086014)2.61820965
139spinal cord development (GO:0021510)2.61025001
140synapse organization (GO:0050808)2.59914752
141mechanosensory behavior (GO:0007638)2.59422145
142phosphorelay signal transduction system (GO:0000160)2.58227281
143adult locomotory behavior (GO:0008344)2.58090421
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.57330384
145regulation of translation, ncRNA-mediated (GO:0045974)2.57330384
146negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57330384
147embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57047162
148calcium ion-dependent exocytosis (GO:0017156)2.55396961
149insulin secretion (GO:0030073)2.54484730
150endocrine pancreas development (GO:0031018)2.51824661
151positive regulation of neurotransmitter transport (GO:0051590)2.51792215
152cAMP-mediated signaling (GO:0019933)2.49472533
153positive regulation of dendritic spine morphogenesis (GO:0061003)2.49325518
154establishment of mitochondrion localization (GO:0051654)2.45256335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25543022
2* GBX2_23144817_ChIP-Seq_PC3_Human4.22978015
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79299342
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95228961
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91893462
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80588641
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.48375758
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48146282
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45732671
10REST_21632747_ChIP-Seq_MESCs_Mouse2.44840447
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42460853
12TAF15_26573619_Chip-Seq_HEK293_Human2.42353867
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39620602
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39620602
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39389404
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.34218254
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26815471
18* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25742845
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20382784
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19769943
21* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16232987
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12268463
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09895951
24IGF1R_20145208_ChIP-Seq_DFB_Human2.09555801
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08765385
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05613257
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.04284072
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99327757
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.99019289
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.93237244
31P300_19829295_ChIP-Seq_ESCs_Human1.92740785
32AR_21572438_ChIP-Seq_LNCaP_Human1.89471169
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89385914
34* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87793422
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85863348
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85548286
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.82423222
38DROSHA_22980978_ChIP-Seq_HELA_Human1.81502536
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72770656
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.72736392
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67381574
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67048133
43RNF2_27304074_Chip-Seq_NSC_Mouse1.58286164
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.54811434
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54657375
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.54256303
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53711487
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.51995731
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.51754740
50FUS_26573619_Chip-Seq_HEK293_Human1.50327392
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50280189
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45896676
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45754848
54VDR_22108803_ChIP-Seq_LS180_Human1.43258762
55AR_25329375_ChIP-Seq_VCAP_Human1.42854206
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41935108
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40187392
58STAT3_23295773_ChIP-Seq_U87_Human1.39375113
59ZNF274_21170338_ChIP-Seq_K562_Hela1.36318509
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35511927
61EWS_26573619_Chip-Seq_HEK293_Human1.35170362
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30890376
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30684573
64CBP_20019798_ChIP-Seq_JUKART_Human1.29929545
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29929545
66* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29144537
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28532586
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27949704
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26560398
70* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24966629
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24945561
72TCF4_23295773_ChIP-Seq_U87_Human1.22988394
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22153730
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20901235
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20901235
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20855815
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19938594
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19029067
79ER_23166858_ChIP-Seq_MCF-7_Human1.17479710
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.17453487
81* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16022351
82RUNX2_22187159_ChIP-Seq_PCA_Human1.14812804
83* AHR_22903824_ChIP-Seq_MCF-7_Human1.14660524
84* E2F1_18555785_Chip-Seq_ESCs_Mouse1.10952142
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10721516
86* AR_19668381_ChIP-Seq_PC3_Human1.10673369
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.10406434
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10297335
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10068817
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.09854349
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08980471
92JUN_21703547_ChIP-Seq_K562_Human1.08751236
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07130022
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05145636
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.05119504
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04157836
97BCAT_22108803_ChIP-Seq_LS180_Human1.03675232
98* P53_22387025_ChIP-Seq_ESCs_Mouse1.02770920
99* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02625494
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02611412
101* KDM2B_26808549_Chip-Seq_REH_Human1.02365008
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.02329075
103TP53_18474530_ChIP-ChIP_U2OS_Human1.01893012
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00262006
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98269216
106TCF4_22108803_ChIP-Seq_LS180_Human0.98009463
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.97469380
108RING1B_27294783_Chip-Seq_NPCs_Mouse0.97042124
109* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96770430
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96712261
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96076734
112SMAD4_21741376_ChIP-Seq_EPCs_Human0.95638737
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94679756
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94676463
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94065613
116SOX9_26525672_Chip-Seq_HEART_Mouse0.93086813
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93073350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.95149881
2MP0004859_abnormal_synaptic_plasticity4.28577901
3MP0002735_abnormal_chemical_nociception4.04538010
4MP0001968_abnormal_touch/_nociception3.96630443
5MP0004270_analgesia3.71187701
6MP0002736_abnormal_nociception_after3.47291803
7MP0003635_abnormal_synaptic_transmissio3.33075273
8MP0006276_abnormal_autonomic_nervous3.16097234
9MP0002734_abnormal_mechanical_nocicepti3.02533334
10MP0009745_abnormal_behavioral_response2.90669536
11MP0002063_abnormal_learning/memory/cond2.77938793
12MP0009046_muscle_twitch2.68880292
13MP0002064_seizures2.63676277
14MP0002272_abnormal_nervous_system2.60658791
15MP0002572_abnormal_emotion/affect_behav2.57059748
16MP0005423_abnormal_somatic_nervous2.41980922
17MP0002733_abnormal_thermal_nociception2.37977288
18MP0001486_abnormal_startle_reflex2.37221410
19MP0001970_abnormal_pain_threshold2.28767072
20MP0001188_hyperpigmentation2.26594788
21MP0002067_abnormal_sensory_capabilities2.25691282
22MP0001984_abnormal_olfaction2.24967630
23MP0002184_abnormal_innervation2.17399676
24MP0001501_abnormal_sleep_pattern2.01071990
25MP0001440_abnormal_grooming_behavior1.94794211
26MP0000778_abnormal_nervous_system1.89688323
27MP0004858_abnormal_nervous_system1.88403169
28MP0001986_abnormal_taste_sensitivity1.85099443
29MP0002557_abnormal_social/conspecific_i1.71251398
30MP0010386_abnormal_urinary_bladder1.69691302
31MP0005646_abnormal_pituitary_gland1.68136016
32MP0008877_abnormal_DNA_methylation1.67860175
33MP0001529_abnormal_vocalization1.67168932
34MP0005645_abnormal_hypothalamus_physiol1.62386929
35MP0004924_abnormal_behavior1.59199759
36MP0005386_behavior/neurological_phenoty1.59199759
37MP0005551_abnormal_eye_electrophysiolog1.58226940
38MP0003879_abnormal_hair_cell1.55641387
39MP0004811_abnormal_neuron_physiology1.51403451
40MP0000955_abnormal_spinal_cord1.50134448
41MP0001502_abnormal_circadian_rhythm1.49335809
42MP0001944_abnormal_pancreas_morphology1.46212471
43MP0008569_lethality_at_weaning1.44036649
44MP0002882_abnormal_neuron_morphology1.42992218
45MP0002909_abnormal_adrenal_gland1.36890349
46MP0002163_abnormal_gland_morphology1.36545385
47MP0001905_abnormal_dopamine_level1.34499593
48MP0003122_maternal_imprinting1.32334323
49MP0003283_abnormal_digestive_organ1.31204523
50MP0002837_dystrophic_cardiac_calcinosis1.29283023
51MP0002066_abnormal_motor_capabilities/c1.25127387
52MP0004142_abnormal_muscle_tone1.24866267
53MP0002822_catalepsy1.24711324
54MP0003787_abnormal_imprinting1.24635941
55MP0009780_abnormal_chondrocyte_physiolo1.24552272
56MP0003121_genomic_imprinting1.22539063
57MP0002751_abnormal_autonomic_nervous1.20778153
58MP0003329_amyloid_beta_deposits1.19822278
59MP0005187_abnormal_penis_morphology1.19600552
60MP0006072_abnormal_retinal_apoptosis1.18142569
61MP0004742_abnormal_vestibular_system1.16829823
62MP0004133_heterotaxia1.14226198
63MP0001963_abnormal_hearing_physiology1.12740679
64MP0004145_abnormal_muscle_electrophysio1.12059215
65MP0002752_abnormal_somatic_nervous1.11179907
66MP0002229_neurodegeneration1.10780688
67MP0008057_abnormal_DNA_replication1.08132152
68MP0003890_abnormal_embryonic-extraembry1.07298719
69MP0002876_abnormal_thyroid_physiology1.06798601
70MP0000631_abnormal_neuroendocrine_gland1.06199069
71MP0003195_calcinosis1.05474113
72MP0006292_abnormal_olfactory_placode1.03878146
73MP0002638_abnormal_pupillary_reflex1.03366952
74MP0003123_paternal_imprinting0.98493430
75MP0002693_abnormal_pancreas_physiology0.98250831
76MP0003633_abnormal_nervous_system0.97694215
77MP0005409_darkened_coat_color0.97557908
78MP0000372_irregular_coat_pigmentation0.96215320
79MP0000569_abnormal_digit_pigmentation0.94488695
80MP0003632_abnormal_nervous_system0.92217792
81MP0002152_abnormal_brain_morphology0.90748431
82MP0004043_abnormal_pH_regulation0.89940338
83MP0000026_abnormal_inner_ear0.86488219
84MP0002069_abnormal_eating/drinking_beha0.86217586
85MP0004085_abnormal_heartbeat0.85938805
86MP0005499_abnormal_olfactory_system0.85852610
87MP0005394_taste/olfaction_phenotype0.85852610
88MP0005253_abnormal_eye_physiology0.84314336
89MP0002090_abnormal_vision0.82048080
90MP0003631_nervous_system_phenotype0.80368146
91MP0003953_abnormal_hormone_level0.78775833
92MP0002078_abnormal_glucose_homeostasis0.77346470
93MP0001299_abnormal_eye_distance/0.77130872
94MP0002938_white_spotting0.76497257
95MP0005448_abnormal_energy_balance0.76179093
96MP0004215_abnormal_myocardial_fiber0.76060908
97MP0001485_abnormal_pinna_reflex0.74501559
98MP0001664_abnormal_digestion0.74197326
99MP0005391_vision/eye_phenotype0.73589665
100MP0003646_muscle_fatigue0.73373879
101MP0005535_abnormal_body_temperature0.73224653
102MP0005220_abnormal_exocrine_pancreas0.72679645
103MP0004885_abnormal_endolymph0.72632341
104MP0008872_abnormal_physiological_respon0.71909631
105MP0004147_increased_porphyrin_level0.70362398
106MP0008995_early_reproductive_senescence0.69671689
107MP0005171_absent_coat_pigmentation0.68273324
108MP0003119_abnormal_digestive_system0.67358731
109MP0000751_myopathy0.66969635
110MP0003634_abnormal_glial_cell0.65605477
111MP0000538_abnormal_urinary_bladder0.63195297
112MP0003183_abnormal_peptide_metabolism0.62534515
113MP0000015_abnormal_ear_pigmentation0.62070965
114MP0004233_abnormal_muscle_weight0.61119630
115MP0003137_abnormal_impulse_conducting0.59649704
116MP0001943_abnormal_respiration0.58352871
117MP0008874_decreased_physiological_sensi0.58064821
118MP0004484_altered_response_of0.57599906
119MP0008789_abnormal_olfactory_epithelium0.56035229
120MP0005379_endocrine/exocrine_gland_phen0.55872410
121MP0005195_abnormal_posterior_eye0.55548330
122MP0010770_preweaning_lethality0.48375811
123MP0002082_postnatal_lethality0.48375811
124MP0001177_atelectasis0.48328225
125MP0003861_abnormal_nervous_system0.47914418

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.27887012
2Febrile seizures (HP:0002373)6.39148227
3Epileptic encephalopathy (HP:0200134)5.71143535
4Atonic seizures (HP:0010819)5.20885322
5Myokymia (HP:0002411)5.20118464
6Focal seizures (HP:0007359)5.11347931
7Absence seizures (HP:0002121)4.54611859
8Progressive cerebellar ataxia (HP:0002073)4.25079820
9Dialeptic seizures (HP:0011146)4.05311773
10Hyperventilation (HP:0002883)3.90450808
11Intestinal atresia (HP:0011100)3.85888383
12Visual hallucinations (HP:0002367)3.77233327
13Generalized tonic-clonic seizures (HP:0002069)3.58593299
14Congenital stationary night blindness (HP:0007642)3.45991847
15Action tremor (HP:0002345)3.43278252
16Ulnar claw (HP:0001178)3.40732005
17Pheochromocytoma (HP:0002666)3.09280854
18Broad-based gait (HP:0002136)2.99575082
19Oligodactyly (hands) (HP:0001180)2.96957930
20Truncal ataxia (HP:0002078)2.94968671
21Amblyopia (HP:0000646)2.91336529
22Neuroendocrine neoplasm (HP:0100634)2.86613545
23Gaze-evoked nystagmus (HP:0000640)2.77233010
24Abnormal hair whorl (HP:0010721)2.76969761
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.76369874
26Supranuclear gaze palsy (HP:0000605)2.75212839
27Excessive salivation (HP:0003781)2.75090748
28Drooling (HP:0002307)2.75090748
29Hypothermia (HP:0002045)2.74437888
30Epileptiform EEG discharges (HP:0011182)2.70843649
31Hyperinsulinemic hypoglycemia (HP:0000825)2.70561967
32Gait imbalance (HP:0002141)2.65680086
33Abnormality of the labia minora (HP:0012880)2.64663331
34Absent speech (HP:0001344)2.64531957
35Limb dystonia (HP:0002451)2.60406270
36EEG with generalized epileptiform discharges (HP:0011198)2.54232918
37Inability to walk (HP:0002540)2.51029837
38Termporal pattern (HP:0011008)2.50664114
39Insidious onset (HP:0003587)2.50664114
40Progressive inability to walk (HP:0002505)2.47165530
41Anxiety (HP:0000739)2.44388801
42Medial flaring of the eyebrow (HP:0010747)2.43682908
43Hypoglycemic seizures (HP:0002173)2.42398077
44Double outlet right ventricle (HP:0001719)2.39642426
45Congenital malformation of the right heart (HP:0011723)2.39642426
46Fetal akinesia sequence (HP:0001989)2.39503474
47Nephronophthisis (HP:0000090)2.36423782
48Polyphagia (HP:0002591)2.35314364
49Depression (HP:0000716)2.35152021
50Abnormality of binocular vision (HP:0011514)2.33519695
51Diplopia (HP:0000651)2.33519695
52Congenital primary aphakia (HP:0007707)2.32722721
53Scanning speech (HP:0002168)2.32362672
54Abnormal eating behavior (HP:0100738)2.31865878
55Impaired vibration sensation in the lower limbs (HP:0002166)2.30210526
56Hepatoblastoma (HP:0002884)2.28226535
57Hypoplastic nipples (HP:0002557)2.26413226
58Hypsarrhythmia (HP:0002521)2.26157373
59Nephrogenic diabetes insipidus (HP:0009806)2.25832158
60Failure to thrive in infancy (HP:0001531)2.23799859
61Agitation (HP:0000713)2.23766943
62Hemiparesis (HP:0001269)2.22872243
63Ankle clonus (HP:0011448)2.22278176
64Urinary bladder sphincter dysfunction (HP:0002839)2.22178648
65Protruding tongue (HP:0010808)2.19958473
66Retinal dysplasia (HP:0007973)2.17222829
67Abnormality of the corticospinal tract (HP:0002492)2.16470362
68Abnormality of the metopic suture (HP:0005556)2.15934600
69Dysdiadochokinesis (HP:0002075)2.15737336
70Abnormality of the lower motor neuron (HP:0002366)2.15567547
71Genetic anticipation (HP:0003743)2.14780473
72Blue irides (HP:0000635)2.14598369
73Molar tooth sign on MRI (HP:0002419)2.13800911
74Abnormality of midbrain morphology (HP:0002418)2.13800911
75Central scotoma (HP:0000603)2.12534613
76Spastic gait (HP:0002064)2.12378865
77Large for gestational age (HP:0001520)2.11593905
78Exotropia (HP:0000577)2.11065255
79Genital tract atresia (HP:0001827)2.10877098
80Volvulus (HP:0002580)2.10414242
81Truncal obesity (HP:0001956)2.09784225
82Poor eye contact (HP:0000817)2.09167983
83Hypoglycemic coma (HP:0001325)2.09017513
84Labial hypoplasia (HP:0000066)2.08720175
85Abnormality of macular pigmentation (HP:0008002)2.08048400
86Dysmetria (HP:0001310)2.07813076
87Esotropia (HP:0000565)2.05707186
88Akinesia (HP:0002304)2.04455767
89Muscular hypotonia of the trunk (HP:0008936)2.03943302
90Chronic hepatic failure (HP:0100626)2.02712756
91Abnormality of the pubic bones (HP:0003172)2.01937257
92Vaginal atresia (HP:0000148)2.01503746
93Bony spicule pigmentary retinopathy (HP:0007737)1.99901347
94Hypoplasia of the brainstem (HP:0002365)1.99817673
95Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99817673
96Specific learning disability (HP:0001328)1.99641222
97Abnormality of salivation (HP:0100755)1.98781619
98Abnormality of pain sensation (HP:0010832)1.98308008
99Impaired pain sensation (HP:0007328)1.98308008
100Abnormal social behavior (HP:0012433)1.96345537
101Impaired social interactions (HP:0000735)1.96345537
102Esophageal atresia (HP:0002032)1.96292937
103Hyperthyroidism (HP:0000836)1.94263344
104Steppage gait (HP:0003376)1.92979234
105Thyroid-stimulating hormone excess (HP:0002925)1.92730774
106Abnormality of the renal medulla (HP:0100957)1.92393038
107Urinary urgency (HP:0000012)1.91594887
108Gastrointestinal atresia (HP:0002589)1.89056346
109Poor suck (HP:0002033)1.88653730
110Hypoventilation (HP:0002791)1.87970379
111Aplasia/Hypoplasia of the sternum (HP:0006714)1.86607139
112Ketoacidosis (HP:0001993)1.85661695
113Mutism (HP:0002300)1.85621248
114Decreased central vision (HP:0007663)1.84930828
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84383802
116Bradycardia (HP:0001662)1.83745623
117Impaired smooth pursuit (HP:0007772)1.82869953
118Narrow forehead (HP:0000341)1.82272212
119Neoplasm of the heart (HP:0100544)1.81941401
120Prolonged QT interval (HP:0001657)1.79666889
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78185870
122Septo-optic dysplasia (HP:0100842)1.77045109
123Hypoplastic female external genitalia (HP:0012815)1.76591211
124Bradykinesia (HP:0002067)1.76249592
125Dysautonomia (HP:0002459)1.75706181
126Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75313587
127Pancreatic cysts (HP:0001737)1.74983121
128Generalized hypopigmentation of hair (HP:0011358)1.73301035
129Narrow nasal bridge (HP:0000446)1.72600979
130Pancreatic fibrosis (HP:0100732)1.72322007
131Widely spaced teeth (HP:0000687)1.71341120
132Lower limb muscle weakness (HP:0007340)1.71286065
133Hypoplastic labia majora (HP:0000059)1.69747508
134Optic nerve hypoplasia (HP:0000609)1.69497211
135Lissencephaly (HP:0001339)1.69153457
136Highly arched eyebrow (HP:0002553)1.68674416
137Poor coordination (HP:0002370)1.68485476
138Intellectual disability, progressive (HP:0006887)1.66628332
139Pachygyria (HP:0001302)1.65845865
140Spinal muscular atrophy (HP:0007269)1.65492527
141Delusions (HP:0000746)1.65215043
142Abnormality of calcium-phosphate metabolism (HP:0100530)1.65169711
143Status epilepticus (HP:0002133)1.65119721
144Hammertoe (HP:0001765)1.64378300
145Stereotypic behavior (HP:0000733)1.63407974
146Submucous cleft hard palate (HP:0000176)1.63387138
147Insulin-resistant diabetes mellitus (HP:0000831)1.62918853
148Hyperglycemia (HP:0003074)1.62080984
149Abnormality of the antihelix (HP:0009738)1.61675753
150Abnormal EKG (HP:0003115)1.61607312
151Hypoplastic ischia (HP:0003175)1.61473122
152Prominent metopic ridge (HP:0005487)1.60550037
153Abnormality of abdominal situs (HP:0011620)1.58778579
154Abdominal situs inversus (HP:0003363)1.58778579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.70668805
2CASK4.44408454
3EPHA43.14427851
4MAP3K43.14233485
5MAP2K73.13491773
6MINK12.73388397
7MARK12.70421294
8MAP4K22.69810673
9MAP3K92.54445442
10MAP3K122.51137665
11RIPK42.17629664
12NTRK12.09505410
13MAPK132.04773743
14TNIK1.97913993
15MAP2K41.82728049
16TLK11.71492052
17PAK61.65580954
18SIK31.57932516
19PLK21.57309889
20DAPK21.53392008
21GRK11.51670160
22GRK51.50923303
23NTRK21.48102400
24PNCK1.46915509
25PRPF4B1.41127868
26SIK21.40480491
27KSR11.37516652
28CSNK1G11.34373904
29KSR21.32134856
30PRKCG1.27752570
31CDK51.26268492
32AKT31.23322192
33CSNK1G31.22735578
34SGK21.22138324
35CAMKK21.21900581
36PHKG21.18819749
37PHKG11.18819749
38ZAK1.18057295
39SGK2231.15230510
40SGK4941.15230510
41ARAF1.14606562
42CAMK2A1.11755242
43DAPK11.11192795
44CSNK1A1L1.09034432
45WNK31.07251389
46ACVR1B1.04686262
47BMPR20.99064070
48INSRR0.98130676
49ADRBK20.96136594
50IRAK20.94502797
51LMTK20.93159811
52MAP3K20.93119464
53PKN10.92879938
54NME10.91881414
55GRK70.91499562
56PRKCE0.91031291
57UHMK10.88879792
58CAMK40.85361586
59PRKAA10.84428242
60BMPR1B0.83921200
61FER0.83137089
62LATS20.82703617
63FES0.82414810
64CAMK1D0.80572365
65CAMK2B0.79746887
66CAMKK10.79719324
67PAK30.78232287
68CDK190.78067777
69FRK0.74896329
70DYRK1A0.74890521
71RET0.69939447
72FGFR20.69834722
73CAMK1G0.69226767
74CSNK1D0.68622390
75STK380.67192736
76CSNK1E0.66991562
77YES10.66091945
78SGK30.66025474
79TNK20.65780627
80CCNB10.65527419
81CSNK1A10.65082469
82VRK10.64543244
83MAP3K130.64452585
84CAMK10.63236567
85BCR0.63172160
86CSNK1G20.61545414
87SGK10.61541914
88MAP2K10.60123701
89WNK10.59803458
90CDK140.59642251
91CAMK2D0.58272870
92MUSK0.57828586
93OXSR10.57495188
94ADRBK10.56980871
95PRKD30.56547701
96BRAF0.55181288
97CDK180.55164875
98PINK10.55075601
99ERBB20.54388526
100RPS6KA20.52936612
101PTK2B0.52526935
102TRIM280.48455914
103CDK150.46713743
104PRKACA0.46389655
105PRKCZ0.45380859
106MKNK20.43769975
107TAOK10.43694612
108EPHA30.43545076
109DYRK30.43283235
110CAMK2G0.42526892
111FGR0.42012042
112CDK30.41959735
113PASK0.41132395
114DYRK20.40961173
115STK110.40778926
116PRKG10.40566899
117GSK3B0.40210922
118CDK11A0.39550620
119ATM0.39418570
120MAPK100.38857852
121MAP3K10.38615503
122RPS6KB10.38251792
123PRKCB0.38215947
124PRKACB0.36421499
125ERBB30.36262570
126PRKDC0.35875580
127STK38L0.35538113
128PRKCH0.34978005
129RPS6KA30.34525783
130STK390.34413404
131WNK40.34269467
132MAP3K60.33331604
133STK30.30894864
134PRKCA0.28713855
135MAPK80.27859925
136MAP3K50.27151241
137ICK0.26571002
138MAPK140.25978805

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26611225
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.53215302
3Synaptic vesicle cycle_Homo sapiens_hsa047213.38782303
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82727492
5GABAergic synapse_Homo sapiens_hsa047272.64363204
6Circadian entrainment_Homo sapiens_hsa047132.57040125
7Morphine addiction_Homo sapiens_hsa050322.55040571
8Olfactory transduction_Homo sapiens_hsa047402.47814660
9Glutamatergic synapse_Homo sapiens_hsa047242.35996396
10Long-term potentiation_Homo sapiens_hsa047202.33287629
11Taste transduction_Homo sapiens_hsa047422.32470196
12Insulin secretion_Homo sapiens_hsa049112.23998731
13Amphetamine addiction_Homo sapiens_hsa050312.22446287
14Dopaminergic synapse_Homo sapiens_hsa047282.14312310
15Serotonergic synapse_Homo sapiens_hsa047262.04290183
16Salivary secretion_Homo sapiens_hsa049702.01977069
17Collecting duct acid secretion_Homo sapiens_hsa049662.00205386
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99945651
19Butanoate metabolism_Homo sapiens_hsa006501.86444219
20Cholinergic synapse_Homo sapiens_hsa047251.84818878
21Renin secretion_Homo sapiens_hsa049241.73410689
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64125617
23Calcium signaling pathway_Homo sapiens_hsa040201.62867511
24Long-term depression_Homo sapiens_hsa047301.60993281
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60945104
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49598554
27Oxytocin signaling pathway_Homo sapiens_hsa049211.49343630
28Cocaine addiction_Homo sapiens_hsa050301.48289953
29Phototransduction_Homo sapiens_hsa047441.48160151
30Gastric acid secretion_Homo sapiens_hsa049711.47938045
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46830614
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37934411
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34613568
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30223191
35Cardiac muscle contraction_Homo sapiens_hsa042601.28409999
36Vibrio cholerae infection_Homo sapiens_hsa051101.26931589
37Protein export_Homo sapiens_hsa030601.26542158
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25508750
39GnRH signaling pathway_Homo sapiens_hsa049121.24575810
40Gap junction_Homo sapiens_hsa045401.21035624
41Axon guidance_Homo sapiens_hsa043601.20824440
42cAMP signaling pathway_Homo sapiens_hsa040241.14640287
43Oxidative phosphorylation_Homo sapiens_hsa001901.14490564
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10504996
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06976524
46Alzheimers disease_Homo sapiens_hsa050101.01217104
47Type II diabetes mellitus_Homo sapiens_hsa049300.99326864
48ErbB signaling pathway_Homo sapiens_hsa040120.97945926
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97198130
50Lysine degradation_Homo sapiens_hsa003100.95737779
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92897267
52Melanogenesis_Homo sapiens_hsa049160.92072979
53Estrogen signaling pathway_Homo sapiens_hsa049150.90187783
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.89484959
55Circadian rhythm_Homo sapiens_hsa047100.89096964
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87733407
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85746354
58Selenocompound metabolism_Homo sapiens_hsa004500.85135753
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84236286
60Glioma_Homo sapiens_hsa052140.82893091
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81843813
62Dorso-ventral axis formation_Homo sapiens_hsa043200.79403581
63Parkinsons disease_Homo sapiens_hsa050120.77059225
64Tryptophan metabolism_Homo sapiens_hsa003800.76896497
65Pancreatic secretion_Homo sapiens_hsa049720.74137600
66mTOR signaling pathway_Homo sapiens_hsa041500.73620806
67ABC transporters_Homo sapiens_hsa020100.73421096
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73133563
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71884977
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71337841
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70072305
72MAPK signaling pathway_Homo sapiens_hsa040100.68074771
73Basal transcription factors_Homo sapiens_hsa030220.67088580
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66038261
75Dilated cardiomyopathy_Homo sapiens_hsa054140.65397407
76Oocyte meiosis_Homo sapiens_hsa041140.64664308
77Choline metabolism in cancer_Homo sapiens_hsa052310.63529574
78Ether lipid metabolism_Homo sapiens_hsa005650.60572525
79Ras signaling pathway_Homo sapiens_hsa040140.60363954
80Thyroid hormone synthesis_Homo sapiens_hsa049180.60171597
81AMPK signaling pathway_Homo sapiens_hsa041520.58621602
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58131581
83Folate biosynthesis_Homo sapiens_hsa007900.58028873
84Rheumatoid arthritis_Homo sapiens_hsa053230.57700308
85Glucagon signaling pathway_Homo sapiens_hsa049220.57670478
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.56268427
87Huntingtons disease_Homo sapiens_hsa050160.53043000
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52707309
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52625528
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51994910
91Inositol phosphate metabolism_Homo sapiens_hsa005620.51606164
92Melanoma_Homo sapiens_hsa052180.50104949
93Sphingolipid metabolism_Homo sapiens_hsa006000.49794507
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48583869
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48241433
96Regulation of autophagy_Homo sapiens_hsa041400.47842115
97Type I diabetes mellitus_Homo sapiens_hsa049400.47305318
98Alcoholism_Homo sapiens_hsa050340.45759717
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45710792
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45689012
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.45232495
102Phagosome_Homo sapiens_hsa041450.45152523
103Wnt signaling pathway_Homo sapiens_hsa043100.45074669
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44324198
105Rap1 signaling pathway_Homo sapiens_hsa040150.43875542
106African trypanosomiasis_Homo sapiens_hsa051430.41976873
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41383649
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40835822
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.40167302
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39583532
111Endometrial cancer_Homo sapiens_hsa052130.39464100
112Vitamin B6 metabolism_Homo sapiens_hsa007500.37901667
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37553737
114Ovarian steroidogenesis_Homo sapiens_hsa049130.35108857
115VEGF signaling pathway_Homo sapiens_hsa043700.35066844
116Steroid biosynthesis_Homo sapiens_hsa001000.34714597
117Mineral absorption_Homo sapiens_hsa049780.34111485
118Insulin signaling pathway_Homo sapiens_hsa049100.32120398
119Tight junction_Homo sapiens_hsa045300.29925860
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.27874710
121Prion diseases_Homo sapiens_hsa050200.25781547
122Prolactin signaling pathway_Homo sapiens_hsa049170.25383288
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25145792
124Hedgehog signaling pathway_Homo sapiens_hsa043400.22955007

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