KCNC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.21059001
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07366439
3neuronal action potential propagation (GO:0019227)5.85488427
4synaptic vesicle maturation (GO:0016188)5.83898753
5vocalization behavior (GO:0071625)5.80358956
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.70669658
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56490635
8gamma-aminobutyric acid transport (GO:0015812)5.30047973
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.29877214
10synaptic vesicle exocytosis (GO:0016079)5.27741063
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22983235
12cerebellar granule cell differentiation (GO:0021707)5.01620197
13neurotransmitter secretion (GO:0007269)5.00730241
14glutamate secretion (GO:0014047)4.95129160
15cellular potassium ion homeostasis (GO:0030007)4.90921502
16regulation of synaptic vesicle exocytosis (GO:2000300)4.89242931
17glutamate receptor signaling pathway (GO:0007215)4.84796785
18cerebellar Purkinje cell differentiation (GO:0021702)4.82756070
19synaptic transmission, glutamatergic (GO:0035249)4.71720376
20regulation of glutamate receptor signaling pathway (GO:1900449)4.69597900
21sodium ion export (GO:0071436)4.60123385
22response to pheromone (GO:0019236)4.58975073
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.43841040
24exploration behavior (GO:0035640)4.42039400
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.40086646
26protein localization to synapse (GO:0035418)4.36115805
27regulation of synaptic vesicle transport (GO:1902803)4.35990189
28long-term memory (GO:0007616)4.34490304
29neuron-neuron synaptic transmission (GO:0007270)4.33458810
30regulation of long-term neuronal synaptic plasticity (GO:0048169)4.28295032
31neuromuscular process controlling posture (GO:0050884)4.27044482
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.26469703
33neuron cell-cell adhesion (GO:0007158)4.18711099
34positive regulation of synapse maturation (GO:0090129)4.12285292
35gamma-aminobutyric acid signaling pathway (GO:0007214)4.11098022
36layer formation in cerebral cortex (GO:0021819)4.10482710
37amino acid import (GO:0043090)4.10192893
38regulation of neuronal synaptic plasticity (GO:0048168)4.09047134
39neurotransmitter transport (GO:0006836)4.06291469
40axon ensheathment in central nervous system (GO:0032291)4.03456640
41central nervous system myelination (GO:0022010)4.03456640
42positive regulation of dendritic spine development (GO:0060999)3.93438009
43transmission of nerve impulse (GO:0019226)3.93396242
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.92972464
45neurotransmitter-gated ion channel clustering (GO:0072578)3.90401990
46cell differentiation in hindbrain (GO:0021533)3.90287131
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.89768445
48glycine transport (GO:0015816)3.86954371
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83931632
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83336739
51positive regulation of membrane potential (GO:0045838)3.82574896
52regulation of synapse structural plasticity (GO:0051823)3.81361219
53dendritic spine morphogenesis (GO:0060997)3.80121928
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.76489662
55regulation of neurotransmitter levels (GO:0001505)3.75112909
56neuromuscular process controlling balance (GO:0050885)3.72961265
57regulation of postsynaptic membrane potential (GO:0060078)3.69931305
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.69060949
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68981401
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68651070
61membrane depolarization during action potential (GO:0086010)3.66469194
62potassium ion import (GO:0010107)3.58238234
63negative regulation of dendrite morphogenesis (GO:0050774)3.55508984
64synaptic vesicle endocytosis (GO:0048488)3.54791645
65regulation of neurotransmitter secretion (GO:0046928)3.53852753
66proline transport (GO:0015824)3.50329902
67cell communication by electrical coupling (GO:0010644)3.48929034
68positive regulation of neurotransmitter transport (GO:0051590)3.44388859
69adult walking behavior (GO:0007628)3.43469332
70positive regulation of neurotransmitter secretion (GO:0001956)3.42444785
71membrane depolarization (GO:0051899)3.41871641
72membrane hyperpolarization (GO:0060081)3.41209239
73cerebellar Purkinje cell layer development (GO:0021680)3.40825773
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.37916811
75regulation of synaptic plasticity (GO:0048167)3.33189266
76neurotransmitter uptake (GO:0001504)3.32254466
77presynaptic membrane organization (GO:0097090)3.31307411
78auditory behavior (GO:0031223)3.31286913
79regulation of synapse maturation (GO:0090128)3.30754620
80L-amino acid import (GO:0043092)3.30115027
81dendrite morphogenesis (GO:0048813)3.29971115
82activation of protein kinase A activity (GO:0034199)3.28828548
83potassium ion homeostasis (GO:0055075)3.27031850
84regulation of neurotransmitter transport (GO:0051588)3.26586210
85regulation of dendritic spine development (GO:0060998)3.26229616
86prepulse inhibition (GO:0060134)3.26015759
87long-term synaptic potentiation (GO:0060291)3.25209051
88acidic amino acid transport (GO:0015800)3.22108504
89regulation of vesicle fusion (GO:0031338)3.21665600
90positive regulation of potassium ion transmembrane transport (GO:1901381)3.21621110
91neuron recognition (GO:0008038)3.16777882
92neuromuscular process (GO:0050905)3.16446197
93response to auditory stimulus (GO:0010996)3.15218740
94postsynaptic membrane organization (GO:0001941)3.15082121
95cytoskeletal anchoring at plasma membrane (GO:0007016)3.14946068
96cell communication involved in cardiac conduction (GO:0086065)3.13940139
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13057963
98synaptic vesicle transport (GO:0048489)3.12565891
99establishment of synaptic vesicle localization (GO:0097480)3.12565891
100dendritic spine organization (GO:0097061)3.12563298
101synapse assembly (GO:0007416)3.11778839
102regulation of dendritic spine morphogenesis (GO:0061001)3.11331115
103presynaptic membrane assembly (GO:0097105)3.10895210
104positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09599185
105cellular sodium ion homeostasis (GO:0006883)3.09471869
106neuronal ion channel clustering (GO:0045161)3.08089279
107chemosensory behavior (GO:0007635)3.06221889
108cell migration in hindbrain (GO:0021535)3.06169937
109long term synaptic depression (GO:0060292)3.04351801
110regulation of voltage-gated calcium channel activity (GO:1901385)3.03868818
111establishment of nucleus localization (GO:0040023)3.03247099
112* synaptic transmission (GO:0007268)3.02821661
113learning (GO:0007612)3.01900830
114positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01696007
115neuromuscular synaptic transmission (GO:0007274)3.01461150
116axonal fasciculation (GO:0007413)2.98490787
117regulation of synaptic transmission (GO:0050804)2.97205609
118intraspecies interaction between organisms (GO:0051703)2.95473055
119social behavior (GO:0035176)2.95473055
120regulation of ARF protein signal transduction (GO:0032012)2.95310689
121mechanosensory behavior (GO:0007638)2.92463549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14966053
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.26323237
3GBX2_23144817_ChIP-Seq_PC3_Human3.14331222
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09650589
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06957841
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87769897
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87769897
8DROSHA_22980978_ChIP-Seq_HELA_Human2.80497654
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.73016098
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65122199
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59269214
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57340054
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55909407
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51907767
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50048449
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47788559
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.41963700
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.38160908
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.36842716
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.36644636
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28599576
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.23678568
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.20333578
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14571658
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12892843
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97950417
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97868909
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91561897
29AR_21572438_ChIP-Seq_LNCaP_Human1.78169324
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73029940
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.71292248
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64321392
33SMAD4_21799915_ChIP-Seq_A2780_Human1.59737288
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54663064
35ZNF274_21170338_ChIP-Seq_K562_Hela1.53200114
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40114163
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38209612
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37365090
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33882006
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31288958
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.31187294
42TAF15_26573619_Chip-Seq_HEK293_Human1.28996302
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.27035479
44* AR_19668381_ChIP-Seq_PC3_Human1.26879051
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26464930
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25443019
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.24712666
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23264619
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.21502556
50STAT3_23295773_ChIP-Seq_U87_Human1.20610354
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18562475
52AR_25329375_ChIP-Seq_VCAP_Human1.17710718
53P300_19829295_ChIP-Seq_ESCs_Human1.14930381
54* KDM2B_26808549_Chip-Seq_K562_Human1.14147176
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.13182617
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12277498
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11065247
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.10800883
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.09640112
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08450245
61CTCF_27219007_Chip-Seq_Bcells_Human1.07174712
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06911702
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06593642
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06409022
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06071508
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05974584
67* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05950912
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.05823055
69TCF4_23295773_ChIP-Seq_U87_Human1.05737080
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03673079
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03195968
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02608111
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01871979
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01381619
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00212674
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00146298
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99954452
78YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99861985
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.98967881
80RNF2_27304074_Chip-Seq_NSC_Mouse0.98679429
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97527750
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.97332565
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96398956
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95145826
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94890443
86TP53_16413492_ChIP-PET_HCT116_Human0.94725878
87AHR_22903824_ChIP-Seq_MCF-7_Human0.94235923
88IGF1R_20145208_ChIP-Seq_DFB_Human0.94199128
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94158603
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93114426
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92875356
92RUNX2_22187159_ChIP-Seq_PCA_Human0.92592064
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.92328443
94DPY_21335234_ChIP-Seq_ESCs_Mouse0.91755698
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91641666
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91310377
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91310377
98ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90667147
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89602483
100OCT4_19829295_ChIP-Seq_ESCs_Human0.89166983
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88552361
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87674988
103SMAD3_21741376_ChIP-Seq_HESCs_Human0.87596091
104RXR_22108803_ChIP-Seq_LS180_Human0.85957749
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85575477
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.85416002
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.85268356
108* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85062315
109POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84253631
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83645090
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83179599
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83075023
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82086787
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.81673875
115LXR_22292898_ChIP-Seq_THP-1_Human0.81162388
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80638210
117RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80048591
118* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79696258
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79141840
120SMC4_20622854_ChIP-Seq_HELA_Human0.78377399
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78342198
122KLF4_19829295_ChIP-Seq_ESCs_Human0.77703766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.32273003
2MP0003635_abnormal_synaptic_transmissio4.28252529
3MP0003880_abnormal_central_pattern4.16846163
4* MP0009046_muscle_twitch4.05559177
5* MP0009745_abnormal_behavioral_response3.46701347
6MP0004270_analgesia3.35199255
7* MP0002064_seizures3.34784490
8* MP0002063_abnormal_learning/memory/cond3.12459309
9MP0005423_abnormal_somatic_nervous3.10556116
10MP0002272_abnormal_nervous_system3.04019940
11MP0001968_abnormal_touch/_nociception2.93075517
12* MP0002572_abnormal_emotion/affect_behav2.74297225
13MP0002734_abnormal_mechanical_nocicepti2.74188603
14MP0001486_abnormal_startle_reflex2.68770149
15* MP0008569_lethality_at_weaning2.58207598
16MP0001501_abnormal_sleep_pattern2.53057442
17MP0002067_abnormal_sensory_capabilities2.37811458
18MP0002736_abnormal_nociception_after2.28893284
19MP0001440_abnormal_grooming_behavior2.28580339
20MP0002735_abnormal_chemical_nociception2.23160209
21MP0004145_abnormal_muscle_electrophysio2.20958143
22MP0002184_abnormal_innervation2.10977761
23MP0002733_abnormal_thermal_nociception1.99160430
24MP0001970_abnormal_pain_threshold1.93676104
25MP0002822_catalepsy1.86900533
26MP0002557_abnormal_social/conspecific_i1.85510458
27MP0004142_abnormal_muscle_tone1.82948068
28MP0003329_amyloid_beta_deposits1.74182592
29MP0004924_abnormal_behavior1.73107727
30MP0005386_behavior/neurological_phenoty1.73107727
31MP0004885_abnormal_endolymph1.71448127
32MP0000955_abnormal_spinal_cord1.63429848
33MP0004811_abnormal_neuron_physiology1.62816708
34MP0000778_abnormal_nervous_system1.62229884
35MP0004858_abnormal_nervous_system1.60437235
36MP0003123_paternal_imprinting1.56145157
37* MP0002066_abnormal_motor_capabilities/c1.54381473
38MP0002909_abnormal_adrenal_gland1.50738994
39MP0003879_abnormal_hair_cell1.48404758
40MP0002882_abnormal_neuron_morphology1.44668751
41MP0009780_abnormal_chondrocyte_physiolo1.42636035
42MP0001984_abnormal_olfaction1.42086905
43MP0005646_abnormal_pituitary_gland1.41766273
44MP0003633_abnormal_nervous_system1.41629103
45MP0001502_abnormal_circadian_rhythm1.38894339
46MP0006276_abnormal_autonomic_nervous1.36368809
47MP0004742_abnormal_vestibular_system1.35424812
48MP0003787_abnormal_imprinting1.34816001
49MP0005645_abnormal_hypothalamus_physiol1.33919641
50MP0003631_nervous_system_phenotype1.28602878
51MP0003632_abnormal_nervous_system1.22418885
52MP0003690_abnormal_glial_cell1.18336406
53MP0002152_abnormal_brain_morphology1.14925687
54MP0000920_abnormal_myelination1.13749053
55MP0002229_neurodegeneration1.10680931
56MP0008872_abnormal_physiological_respon1.10017315
57MP0005551_abnormal_eye_electrophysiolog1.09640602
58MP0000751_myopathy1.07968258
59MP0001348_abnormal_lacrimal_gland1.06146196
60MP0001188_hyperpigmentation1.05573785
61MP0003122_maternal_imprinting1.04953370
62MP0000569_abnormal_digit_pigmentation0.99014378
63MP0001177_atelectasis0.93930014
64MP0004147_increased_porphyrin_level0.93469360
65MP0004215_abnormal_myocardial_fiber0.90861186
66MP0001346_abnormal_lacrimal_gland0.90692162
67MP0002069_abnormal_eating/drinking_beha0.90072371
68MP0003634_abnormal_glial_cell0.88901843
69MP0002638_abnormal_pupillary_reflex0.88500763
70MP0008877_abnormal_DNA_methylation0.87916732
71MP0001963_abnormal_hearing_physiology0.86919096
72MP0003283_abnormal_digestive_organ0.84354358
73MP0001905_abnormal_dopamine_level0.83443333
74MP0003137_abnormal_impulse_conducting0.83254632
75MP0008874_decreased_physiological_sensi0.83132077
76MP0000013_abnormal_adipose_tissue0.83043845
77MP0000566_synostosis0.81447844
78MP0004085_abnormal_heartbeat0.80198576
79MP0004484_altered_response_of0.80141953
80MP0002752_abnormal_somatic_nervous0.79412151
81MP0001485_abnormal_pinna_reflex0.77329596
82MP0001299_abnormal_eye_distance/0.76440149
83MP0001986_abnormal_taste_sensitivity0.74836613
84MP0004043_abnormal_pH_regulation0.73659304
85MP0010386_abnormal_urinary_bladder0.71203950
86MP0000604_amyloidosis0.69465266
87MP0005499_abnormal_olfactory_system0.68064692
88MP0005394_taste/olfaction_phenotype0.68064692
89MP0003646_muscle_fatigue0.67184284
90MP0004233_abnormal_muscle_weight0.67093888
91MP0008961_abnormal_basal_metabolism0.65910409
92MP0005167_abnormal_blood-brain_barrier0.65558905
93MP0006072_abnormal_retinal_apoptosis0.64945637
94MP0005409_darkened_coat_color0.64341599
95MP0002090_abnormal_vision0.64176583
96MP0001529_abnormal_vocalization0.63750907
97MP0005623_abnormal_meninges_morphology0.63560055
98MP0000747_muscle_weakness0.62810880
99MP0003121_genomic_imprinting0.62726433
100* MP0010769_abnormal_survival0.62151863
101MP0003075_altered_response_to0.61829410
102MP0002089_abnormal_postnatal_growth/wei0.61732591
103MP0000631_abnormal_neuroendocrine_gland0.60864697
104MP0004510_myositis0.60793532
105MP0010770_preweaning_lethality0.60119718
106MP0002082_postnatal_lethality0.60119718
107* MP0005535_abnormal_body_temperature0.59346184
108MP0001943_abnormal_respiration0.59294662
109* MP0010768_mortality/aging0.58679853
110MP0003861_abnormal_nervous_system0.57095575
111MP0000579_abnormal_nail_morphology0.55690929
112MP0004130_abnormal_muscle_cell0.55288737
113MP0003045_fibrosis0.53130546
114* MP0003956_abnormal_body_size0.50581701
115MP0002249_abnormal_larynx_morphology0.50419537
116MP0000026_abnormal_inner_ear0.49720933

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.65510398
2Myokymia (HP:0002411)6.29285895
3Progressive cerebellar ataxia (HP:0002073)6.14353145
4Focal seizures (HP:0007359)5.95446436
5Action tremor (HP:0002345)5.83542449
6Visual hallucinations (HP:0002367)5.80447044
7Atonic seizures (HP:0010819)5.26916583
8Febrile seizures (HP:0002373)5.11214251
9Gaze-evoked nystagmus (HP:0000640)4.74995282
10Epileptic encephalopathy (HP:0200134)4.58368013
11Absence seizures (HP:0002121)4.36948726
12Dysdiadochokinesis (HP:0002075)4.18772826
13Broad-based gait (HP:0002136)4.06086533
14Generalized tonic-clonic seizures (HP:0002069)3.90061394
15Dialeptic seizures (HP:0011146)3.89116843
16Scanning speech (HP:0002168)3.89045056
17Hemiplegia (HP:0002301)3.73444348
18Dysmetria (HP:0001310)3.67935466
19Genetic anticipation (HP:0003743)3.66154326
20Impaired smooth pursuit (HP:0007772)3.61356167
21Poor eye contact (HP:0000817)3.58260755
22Truncal ataxia (HP:0002078)3.55397749
23Dysmetric saccades (HP:0000641)3.51938481
24Intention tremor (HP:0002080)3.49440578
25Cerebral hypomyelination (HP:0006808)3.44638098
26Supranuclear gaze palsy (HP:0000605)3.40510811
27Abnormality of ocular smooth pursuit (HP:0000617)3.33729102
28Hemiparesis (HP:0001269)3.32871831
29Abnormal social behavior (HP:0012433)3.32453391
30Impaired social interactions (HP:0000735)3.32453391
31Diplopia (HP:0000651)3.23220983
32Abnormality of binocular vision (HP:0011514)3.23220983
33Depression (HP:0000716)3.19845093
34Ankle clonus (HP:0011448)3.03146224
35Anxiety (HP:0000739)3.02090278
36Abnormal eating behavior (HP:0100738)2.96142098
37Postural instability (HP:0002172)2.96128018
38Status epilepticus (HP:0002133)2.95738281
39Impaired vibration sensation in the lower limbs (HP:0002166)2.94494320
40Ventricular fibrillation (HP:0001663)2.87381552
41Abnormality of the lower motor neuron (HP:0002366)2.85691580
42Mutism (HP:0002300)2.76766312
43Urinary bladder sphincter dysfunction (HP:0002839)2.76093445
44Akinesia (HP:0002304)2.69390634
45Craniofacial dystonia (HP:0012179)2.67669160
46Hyperventilation (HP:0002883)2.64035096
47Tetraplegia (HP:0002445)2.61916703
48Sleep apnea (HP:0010535)2.61556272
49Annular pancreas (HP:0001734)2.59000552
50Progressive inability to walk (HP:0002505)2.56460696
51Delusions (HP:0000746)2.53740558
52Spastic gait (HP:0002064)2.51367503
53Abnormality of saccadic eye movements (HP:0000570)2.50555011
54Postural tremor (HP:0002174)2.43300517
55Stereotypic behavior (HP:0000733)2.40160438
56Drooling (HP:0002307)2.37687629
57Excessive salivation (HP:0003781)2.37687629
58Fetal akinesia sequence (HP:0001989)2.37635824
59Agitation (HP:0000713)2.37573935
60Abnormality of the corticospinal tract (HP:0002492)2.32886001
61Horizontal nystagmus (HP:0000666)2.32423139
62Gait ataxia (HP:0002066)2.27768552
63Amblyopia (HP:0000646)2.24632851
64Spastic tetraparesis (HP:0001285)2.24576174
65Urinary urgency (HP:0000012)2.24496597
66Choreoathetosis (HP:0001266)2.22617712
67Bradykinesia (HP:0002067)2.21776399
68Peripheral hypomyelination (HP:0007182)2.20730859
69Absent speech (HP:0001344)2.20701271
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19842064
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.19842064
72Apathy (HP:0000741)2.19832012
73CNS hypomyelination (HP:0003429)2.17204960
74Papilledema (HP:0001085)2.17074197
75Limb ataxia (HP:0002070)2.16944687
76Bundle branch block (HP:0011710)2.16382316
77Pointed chin (HP:0000307)2.10513721
78Neuronal loss in central nervous system (HP:0002529)2.08300341
79Impaired vibratory sensation (HP:0002495)2.07056169
80Epileptiform EEG discharges (HP:0011182)2.04993287
81Lower limb asymmetry (HP:0100559)2.04596756
82Psychosis (HP:0000709)2.04418206
83Megalencephaly (HP:0001355)2.04079879
84Pheochromocytoma (HP:0002666)2.03027938
85EEG with generalized epileptiform discharges (HP:0011198)2.01620701
86Torticollis (HP:0000473)1.99460148
87Neurofibrillary tangles (HP:0002185)1.99125130
88Polyphagia (HP:0002591)1.98947396
89Incomplete penetrance (HP:0003829)1.97515105
90Rapidly progressive (HP:0003678)1.95622677
91Diminished motivation (HP:0000745)1.94775074
92Focal dystonia (HP:0004373)1.94258782
93Clonus (HP:0002169)1.93572741
94Myotonia (HP:0002486)1.93554740
95Generalized myoclonic seizures (HP:0002123)1.93424307
96Amyotrophic lateral sclerosis (HP:0007354)1.92864820
97Hypsarrhythmia (HP:0002521)1.92511798
98Spinal canal stenosis (HP:0003416)1.90036590
99Lower limb muscle weakness (HP:0007340)1.83097413
100Aplasia involving bones of the upper limbs (HP:0009823)1.79656696
101Abnormal EKG (HP:0003115)1.79473809
102Slow progression (HP:0003677)1.77867774
103Unsteady gait (HP:0002317)1.77207901
104Insomnia (HP:0100785)1.75943429
105Aqueductal stenosis (HP:0002410)1.75208568
106Inability to walk (HP:0002540)1.74411833
107Morphological abnormality of the pyramidal tract (HP:0002062)1.74225851
108Cerebral inclusion bodies (HP:0100314)1.72327853
109Increased circulating renin level (HP:0000848)1.72320651
110Rigidity (HP:0002063)1.70639667
111Limb dystonia (HP:0002451)1.70036742
112Exercise-induced myalgia (HP:0003738)1.69737596
113Obstructive sleep apnea (HP:0002870)1.68947306
114Blue irides (HP:0000635)1.68465017
115Neuroendocrine neoplasm (HP:0100634)1.67295003
116Prolonged QT interval (HP:0001657)1.66668529
117Aplasia involving bones of the extremities (HP:0009825)1.62821534
118Aplasia of the phalanges of the hand (HP:0009802)1.62821534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.50522016
2MAP3K93.34427593
3MAP3K43.10141669
4EPHA42.76619618
5MINK12.64206274
6MARK12.57693355
7MAP2K72.54164627
8NTRK22.50788263
9PAK62.43981801
10CAMKK22.34738695
11DAPK22.31419840
12CAMKK12.26193446
13MAP2K42.12106414
14STK382.02586097
15TNIK1.93872011
16PRPF4B1.84443584
17RIPK11.69698116
18WNK11.67966700
19RIPK41.65988172
20CDK191.65607690
21PRKD31.59716769
22NTRK11.57747707
23MAP3K121.57275889
24PNCK1.55508235
25CDK51.49986234
26CASK1.47444557
27KSR21.43136934
28SIK21.37455327
29PRKCG1.35396477
30PINK11.30684410
31MAPK131.30069355
32GRK51.27317019
33TYRO31.25318795
34UHMK11.24763246
35KSR11.19918054
36PHKG21.18107502
37PHKG11.18107502
38SGK2231.16250059
39SGK4941.16250059
40CAMK11.14827870
41PRKCH1.14524106
42FES1.13417873
43PLK21.12820457
44DAPK11.09903088
45STK111.09708415
46SGK21.08056925
47ALK1.03918630
48OXSR11.00979507
49SGK30.97143555
50CAMK2A0.95143670
51CDK150.93712921
52TNK20.93277702
53CDK180.92591835
54MAP3K130.89396194
55CDK140.82901572
56NEK60.82169855
57CDK11A0.81871167
58CAMK2B0.81635472
59DYRK1A0.81444197
60CAMK1G0.80822271
61SGK10.77285223
62CAMK2G0.75132397
63CDC42BPA0.74919086
64RET0.72449328
65FGFR20.71798763
66MAP3K20.70284952
67CAMK40.69883630
68BRSK10.69877102
69TAOK10.67231595
70LMTK20.66583307
71PDK10.65963171
72MARK20.63904131
73ARAF0.62140388
74CAMK2D0.62015473
75RPS6KA30.61050063
76BRAF0.61022919
77PDPK10.58799552
78PAK30.56658793
79MAPKAPK50.56599688
80BMPR20.56463369
81ROCK20.53790837
82FYN0.51340040
83LIMK10.49775342
84DAPK30.48948276
85MAPK100.48606708
86MAP3K110.48430453
87CSNK1G20.48328945
88LATS20.48035546
89PRKG10.46895644
90MAP3K70.46155115
91PRKCE0.44853211
92PRKCZ0.42696820
93MUSK0.42682370
94CCNB10.39596663
95MAP3K10.38443183
96PKN10.38406387
97MAPK120.38353979
98PTK2B0.38221906
99ERBB20.37716095
100PRKCB0.37001251
101PRKACA0.36779419
102PRKCA0.34067338
103FER0.32878707
104MAPK80.32181912
105CSNK1A10.29797664
106SRC0.29467775
107PRKACB0.29443654
108RAF10.29010670
109CSNK1E0.28256265
110PRKG20.26635516
111CSNK1D0.25922257
112RPS6KB10.24838447

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26885768
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21142027
3GABAergic synapse_Homo sapiens_hsa047272.90644461
4Glutamatergic synapse_Homo sapiens_hsa047242.87738614
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87456288
6Circadian entrainment_Homo sapiens_hsa047132.72762386
7Long-term potentiation_Homo sapiens_hsa047202.72159897
8Morphine addiction_Homo sapiens_hsa050322.54465190
9Olfactory transduction_Homo sapiens_hsa047402.35789772
10Salivary secretion_Homo sapiens_hsa049702.28507455
11Amphetamine addiction_Homo sapiens_hsa050312.24204743
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17148533
13Taste transduction_Homo sapiens_hsa047422.10790937
14Long-term depression_Homo sapiens_hsa047302.09499962
15Gastric acid secretion_Homo sapiens_hsa049711.98003778
16Dopaminergic synapse_Homo sapiens_hsa047281.96837526
17Insulin secretion_Homo sapiens_hsa049111.94731021
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85939665
19Cholinergic synapse_Homo sapiens_hsa047251.79361801
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69304737
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69149944
22Calcium signaling pathway_Homo sapiens_hsa040201.63383792
23Oxytocin signaling pathway_Homo sapiens_hsa049211.62723372
24Serotonergic synapse_Homo sapiens_hsa047261.56494780
25Renin secretion_Homo sapiens_hsa049241.46875730
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45421299
27GnRH signaling pathway_Homo sapiens_hsa049121.38231090
28Cocaine addiction_Homo sapiens_hsa050301.36970542
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36754719
30Type II diabetes mellitus_Homo sapiens_hsa049301.36543492
31cAMP signaling pathway_Homo sapiens_hsa040241.31049465
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27910249
33Vitamin B6 metabolism_Homo sapiens_hsa007501.27689505
34Gap junction_Homo sapiens_hsa045401.21467672
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19801740
36Cardiac muscle contraction_Homo sapiens_hsa042601.14209462
37Estrogen signaling pathway_Homo sapiens_hsa049151.14018903
38Nitrogen metabolism_Homo sapiens_hsa009101.13400310
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11119734
40Pancreatic secretion_Homo sapiens_hsa049721.10067401
41Collecting duct acid secretion_Homo sapiens_hsa049661.08830908
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03552297
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01197935
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94585448
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92143545
46Thyroid hormone synthesis_Homo sapiens_hsa049180.91324053
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.89891960
48Axon guidance_Homo sapiens_hsa043600.89821044
49Melanogenesis_Homo sapiens_hsa049160.89766792
50ErbB signaling pathway_Homo sapiens_hsa040120.88554088
51Glioma_Homo sapiens_hsa052140.87510240
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.86098872
53Dilated cardiomyopathy_Homo sapiens_hsa054140.82878267
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78846784
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78318740
56Phototransduction_Homo sapiens_hsa047440.76828336
57Oocyte meiosis_Homo sapiens_hsa041140.74955486
58Dorso-ventral axis formation_Homo sapiens_hsa043200.73511665
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72464237
60MAPK signaling pathway_Homo sapiens_hsa040100.71763705
61Inositol phosphate metabolism_Homo sapiens_hsa005620.70946274
62Choline metabolism in cancer_Homo sapiens_hsa052310.69922469
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68935490
64Bile secretion_Homo sapiens_hsa049760.65286735
65Prion diseases_Homo sapiens_hsa050200.65161483
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63547923
67Circadian rhythm_Homo sapiens_hsa047100.61123274
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58368151
69Vibrio cholerae infection_Homo sapiens_hsa051100.58127997
70Type I diabetes mellitus_Homo sapiens_hsa049400.54983877
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54961612
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54119936
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53962040
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.53452010
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51527059
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48386915
77Arginine biosynthesis_Homo sapiens_hsa002200.46335388
78Glucagon signaling pathway_Homo sapiens_hsa049220.45825209
79Rap1 signaling pathway_Homo sapiens_hsa040150.45801862
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45341178
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.44277967
82Arginine and proline metabolism_Homo sapiens_hsa003300.44076408
83mTOR signaling pathway_Homo sapiens_hsa041500.43712098
84Ras signaling pathway_Homo sapiens_hsa040140.43501004
85VEGF signaling pathway_Homo sapiens_hsa043700.43219751
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42361420
87Endocytosis_Homo sapiens_hsa041440.40879765
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38211048
89Alcoholism_Homo sapiens_hsa050340.36758649
90Ovarian steroidogenesis_Homo sapiens_hsa049130.36382557
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34834074
92Wnt signaling pathway_Homo sapiens_hsa043100.34591497
93Fatty acid biosynthesis_Homo sapiens_hsa000610.33856232
94Mineral absorption_Homo sapiens_hsa049780.33804634
95Chemokine signaling pathway_Homo sapiens_hsa040620.33583204
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31579075
97Endometrial cancer_Homo sapiens_hsa052130.30166140
98Non-small cell lung cancer_Homo sapiens_hsa052230.29142352
99Alzheimers disease_Homo sapiens_hsa050100.28073894
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27761683
101Insulin signaling pathway_Homo sapiens_hsa049100.27654421
102AMPK signaling pathway_Homo sapiens_hsa041520.27569422
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.27344975
104Renal cell carcinoma_Homo sapiens_hsa052110.26928232
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25354830
106Histidine metabolism_Homo sapiens_hsa003400.25059271
107African trypanosomiasis_Homo sapiens_hsa051430.24272850
108Platelet activation_Homo sapiens_hsa046110.21769456
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20827012
110Tight junction_Homo sapiens_hsa045300.20318714
111beta-Alanine metabolism_Homo sapiens_hsa004100.18614416
112Hippo signaling pathway_Homo sapiens_hsa043900.17675727

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