KCNC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.94450984
2synaptic vesicle exocytosis (GO:0016079)5.78338358
3vocalization behavior (GO:0071625)5.76466284
4neuronal action potential propagation (GO:0019227)5.60214607
5glutamate secretion (GO:0014047)5.59505711
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.37653601
7regulation of synaptic vesicle exocytosis (GO:2000300)5.27295699
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22129767
9synaptic vesicle maturation (GO:0016188)5.19345832
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.16045520
11sodium ion export (GO:0071436)5.13205329
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.09646989
13regulation of glutamate receptor signaling pathway (GO:1900449)5.08499569
14locomotory exploration behavior (GO:0035641)4.94141751
15neurotransmitter secretion (GO:0007269)4.93783637
16gamma-aminobutyric acid transport (GO:0015812)4.92205793
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76167616
18neuron cell-cell adhesion (GO:0007158)4.74042427
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.72400672
20regulation of synaptic vesicle transport (GO:1902803)4.61945123
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.60425306
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.51449468
23protein localization to synapse (GO:0035418)4.51311312
24L-amino acid import (GO:0043092)4.45392322
25neurotransmitter-gated ion channel clustering (GO:0072578)4.44013480
26neuron-neuron synaptic transmission (GO:0007270)4.39089398
27synaptic transmission, glutamatergic (GO:0035249)4.30348560
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.28668818
29amino acid import (GO:0043090)4.16274141
30proline transport (GO:0015824)4.11043307
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07452486
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.03826541
33glutamate receptor signaling pathway (GO:0007215)4.00240342
34regulation of neuronal synaptic plasticity (GO:0048168)4.00202578
35neuromuscular process controlling posture (GO:0050884)3.98544928
36neurotransmitter transport (GO:0006836)3.98534594
37regulation of voltage-gated calcium channel activity (GO:1901385)3.95333487
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94571967
39exploration behavior (GO:0035640)3.89699659
40cerebellar granule cell differentiation (GO:0021707)3.84954578
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.79308062
42long-term synaptic potentiation (GO:0060291)3.77405463
43presynaptic membrane assembly (GO:0097105)3.76627479
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73915401
45long-term memory (GO:0007616)3.73020465
46response to histamine (GO:0034776)3.72495653
47regulation of neurotransmitter levels (GO:0001505)3.65973604
48positive regulation of membrane potential (GO:0045838)3.63546458
49potassium ion homeostasis (GO:0055075)3.62433436
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.62161499
51potassium ion import (GO:0010107)3.57130635
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55985353
53postsynaptic membrane organization (GO:0001941)3.53198812
54positive regulation of dendritic spine development (GO:0060999)3.52286921
55transferrin transport (GO:0033572)3.51618414
56neurotransmitter uptake (GO:0001504)3.51035986
57positive regulation of neurotransmitter secretion (GO:0001956)3.50231888
58ATP hydrolysis coupled proton transport (GO:0015991)3.50097062
59energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.50097062
60cellular sodium ion homeostasis (GO:0006883)3.49775221
61positive regulation of neurotransmitter transport (GO:0051590)3.49396434
62cerebellar Purkinje cell differentiation (GO:0021702)3.49362005
63regulation of synapse maturation (GO:0090128)3.48824410
64presynaptic membrane organization (GO:0097090)3.48434070
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.46981924
66regulation of neurotransmitter secretion (GO:0046928)3.46077765
67regulation of synaptic plasticity (GO:0048167)3.44176945
68cell communication by electrical coupling (GO:0010644)3.43152597
69neuron recognition (GO:0008038)3.41910226
70regulation of synaptic transmission, GABAergic (GO:0032228)3.41698482
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.41583204
72positive regulation of dendritic spine morphogenesis (GO:0061003)3.40812329
73regulation of postsynaptic membrane potential (GO:0060078)3.40570404
74central nervous system myelination (GO:0022010)3.38314293
75axon ensheathment in central nervous system (GO:0032291)3.38314293
76activation of protein kinase A activity (GO:0034199)3.35958565
77regulation of synapse structural plasticity (GO:0051823)3.35337156
78regulation of dendritic spine development (GO:0060998)3.33877407
79regulation of neurotransmitter transport (GO:0051588)3.31241426
80transmission of nerve impulse (GO:0019226)3.29839677
81trivalent inorganic cation transport (GO:0072512)3.27666848
82ferric iron transport (GO:0015682)3.27666848
83neuromuscular synaptic transmission (GO:0007274)3.25163816
84NADH metabolic process (GO:0006734)3.24243971
85synaptic vesicle endocytosis (GO:0048488)3.23823785
86serotonin metabolic process (GO:0042428)3.23688789
87establishment of synaptic vesicle localization (GO:0097480)3.23635606
88synaptic vesicle transport (GO:0048489)3.23635606
89positive regulation of synaptic transmission (GO:0050806)3.23588233
90* synaptic transmission (GO:0007268)3.23389529
91membrane depolarization during action potential (GO:0086010)3.22632497
92regulation of synaptic transmission, dopaminergic (GO:0032225)3.20861300
93cellular potassium ion homeostasis (GO:0030007)3.20236174
94startle response (GO:0001964)3.19471760
95membrane hyperpolarization (GO:0060081)3.17509702
96layer formation in cerebral cortex (GO:0021819)3.15654110
97auditory behavior (GO:0031223)3.15416971
98striatum development (GO:0021756)3.13977941
99negative regulation of dendrite morphogenesis (GO:0050774)3.12760764
100membrane depolarization (GO:0051899)3.11863288
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09224185
102neuromuscular process controlling balance (GO:0050885)3.08946287
103positive regulation of synapse maturation (GO:0090129)3.08354832
104regulation of synaptic transmission (GO:0050804)3.07943262
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07844806
106neuronal ion channel clustering (GO:0045161)3.02155405
107dendritic spine morphogenesis (GO:0060997)3.02097937
108learning (GO:0007612)3.01533485
109adult walking behavior (GO:0007628)3.00893810
110primary amino compound metabolic process (GO:1901160)3.00869347
111regulation of vesicle fusion (GO:0031338)3.00269323
112regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.99882206
113regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.99882206
114succinate metabolic process (GO:0006105)2.99755226
115female mating behavior (GO:0060180)2.97721508
116vesicle docking involved in exocytosis (GO:0006904)2.96927872
117signal release (GO:0023061)2.96634887
118regulation of female receptivity (GO:0045924)2.95993345
119dendritic spine organization (GO:0097061)2.95867886
120behavioral defense response (GO:0002209)2.95340594
121detection of calcium ion (GO:0005513)2.95207973
122neuromuscular process (GO:0050905)2.90290933
123mechanosensory behavior (GO:0007638)2.86508811
124regulation of protein kinase A signaling (GO:0010738)2.84803996
125oxaloacetate metabolic process (GO:0006107)2.84469209
126behavioral response to cocaine (GO:0048148)2.81698795
127regulation of dendritic spine morphogenesis (GO:0061001)2.81624854
128acidic amino acid transport (GO:0015800)2.81000273
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80553369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79866241
2GBX2_23144817_ChIP-Seq_PC3_Human4.45406371
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19844317
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99940279
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97342527
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.73598794
7TAF15_26573619_Chip-Seq_HEK293_Human2.69101084
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60488544
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52515828
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52515828
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52474633
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49159005
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47932750
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47804866
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43836384
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.41681241
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40251312
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38374804
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.37448069
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.28332552
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.19750074
22DROSHA_22980978_ChIP-Seq_HELA_Human2.17756949
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16179241
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15937974
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09004396
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08656144
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04589778
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01185170
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.99771259
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.86410224
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84879162
32AR_21572438_ChIP-Seq_LNCaP_Human1.82959600
33P300_19829295_ChIP-Seq_ESCs_Human1.73852575
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73244791
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72109031
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68969352
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66286078
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59674184
39* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57908457
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55047209
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47050166
42AR_25329375_ChIP-Seq_VCAP_Human1.45604878
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.42067873
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41397539
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.40938581
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40246296
47* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39088790
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37980072
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.37219981
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.35740047
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34910445
52* PIAS1_25552417_ChIP-Seq_VCAP_Human1.34470288
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.33568702
54FUS_26573619_Chip-Seq_HEK293_Human1.33561022
55STAT3_23295773_ChIP-Seq_U87_Human1.32597193
56ZNF274_21170338_ChIP-Seq_K562_Hela1.31628899
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31404302
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22828816
59RNF2_27304074_Chip-Seq_NSC_Mouse1.22439274
60IGF1R_20145208_ChIP-Seq_DFB_Human1.22412089
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22329367
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21113989
63VDR_22108803_ChIP-Seq_LS180_Human1.20997352
64TCF4_23295773_ChIP-Seq_U87_Human1.19743415
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16655488
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16266318
67ER_23166858_ChIP-Seq_MCF-7_Human1.15261219
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12972033
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12481577
70* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12452701
71* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11493784
72RUNX2_22187159_ChIP-Seq_PCA_Human1.09425673
73AR_19668381_ChIP-Seq_PC3_Human1.09038914
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08402997
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08295126
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08232318
77JUN_21703547_ChIP-Seq_K562_Human1.08063892
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05501556
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.05451871
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03563536
81* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03255127
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03247367
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02212187
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01079172
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.00177184
86* AHR_22903824_ChIP-Seq_MCF-7_Human0.98467309
87CBP_20019798_ChIP-Seq_JUKART_Human0.97368991
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97368991
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96028190
90* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95060742
91* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93128468
92TET1_21490601_ChIP-Seq_MESCs_Mouse0.90477363
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.89493297
94* KDM2B_26808549_Chip-Seq_REH_Human0.89071843
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.88945446
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88552209
97* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88036883
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88008801
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87808699
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.87639257
101BCAT_22108803_ChIP-Seq_LS180_Human0.87293260
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87244994
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86908404
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86908404
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.86554538
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86096123
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86024177
108* FLI1_21867929_ChIP-Seq_TH2_Mouse0.85638610
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85633536
110SOX9_26525672_Chip-Seq_HEART_Mouse0.85413609
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.85336981
112* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84183405
113KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83095676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.89845569
2MP0003880_abnormal_central_pattern5.17928388
3MP0003635_abnormal_synaptic_transmissio4.15331067
4* MP0009745_abnormal_behavioral_response3.54842261
5* MP0009046_muscle_twitch3.50913891
6MP0004270_analgesia3.49083554
7* MP0002064_seizures3.47515815
8MP0002063_abnormal_learning/memory/cond3.26954196
9MP0001968_abnormal_touch/_nociception3.23235258
10* MP0002272_abnormal_nervous_system2.87558922
11* MP0002572_abnormal_emotion/affect_behav2.86088647
12MP0002736_abnormal_nociception_after2.62902802
13MP0002734_abnormal_mechanical_nocicepti2.56052212
14MP0001486_abnormal_startle_reflex2.55270556
15MP0002735_abnormal_chemical_nociception2.29243299
16MP0005646_abnormal_pituitary_gland2.24327983
17* MP0001501_abnormal_sleep_pattern2.20701900
18MP0005423_abnormal_somatic_nervous2.18330850
19MP0003787_abnormal_imprinting2.15594779
20MP0002067_abnormal_sensory_capabilities2.14835210
21MP0001440_abnormal_grooming_behavior2.11119051
22MP0009780_abnormal_chondrocyte_physiolo2.07469575
23MP0003122_maternal_imprinting2.06027728
24MP0001970_abnormal_pain_threshold1.98277043
25MP0006276_abnormal_autonomic_nervous1.96593357
26MP0002822_catalepsy1.96283475
27MP0002733_abnormal_thermal_nociception1.94624908
28MP0003879_abnormal_hair_cell1.74374121
29MP0002557_abnormal_social/conspecific_i1.72401229
30MP0008569_lethality_at_weaning1.72237301
31MP0002184_abnormal_innervation1.71657643
32MP0005386_behavior/neurological_phenoty1.66560166
33MP0004924_abnormal_behavior1.66560166
34MP0004142_abnormal_muscle_tone1.63591094
35MP0001984_abnormal_olfaction1.59186827
36MP0004811_abnormal_neuron_physiology1.58484264
37MP0001529_abnormal_vocalization1.58397835
38MP0005645_abnormal_hypothalamus_physiol1.51419287
39MP0003329_amyloid_beta_deposits1.48768586
40MP0004858_abnormal_nervous_system1.46453968
41MP0002909_abnormal_adrenal_gland1.46036341
42MP0002066_abnormal_motor_capabilities/c1.42666082
43MP0000751_myopathy1.42597436
44MP0000778_abnormal_nervous_system1.42370303
45MP0000955_abnormal_spinal_cord1.39118447
46MP0002882_abnormal_neuron_morphology1.34224593
47MP0010386_abnormal_urinary_bladder1.33831258
48MP0002837_dystrophic_cardiac_calcinosis1.30909512
49MP0001905_abnormal_dopamine_level1.28739101
50MP0002876_abnormal_thyroid_physiology1.27942114
51MP0001986_abnormal_taste_sensitivity1.27844291
52MP0004147_increased_porphyrin_level1.27594381
53MP0003633_abnormal_nervous_system1.20764859
54MP0000013_abnormal_adipose_tissue1.19991148
55MP0008872_abnormal_physiological_respon1.10661449
56MP0001502_abnormal_circadian_rhythm1.09123216
57MP0003646_muscle_fatigue1.06526280
58MP0003631_nervous_system_phenotype1.05466242
59MP0002229_neurodegeneration1.04031578
60MP0005551_abnormal_eye_electrophysiolog1.03104486
61MP0008877_abnormal_DNA_methylation1.01967499
62MP0001188_hyperpigmentation0.97960717
63MP0002152_abnormal_brain_morphology0.97527614
64MP0003183_abnormal_peptide_metabolism0.95718315
65MP0001963_abnormal_hearing_physiology0.95445912
66MP0000569_abnormal_digit_pigmentation0.93933166
67MP0002069_abnormal_eating/drinking_beha0.89638235
68MP0004215_abnormal_myocardial_fiber0.89465519
69MP0004885_abnormal_endolymph0.89037877
70MP0008874_decreased_physiological_sensi0.88292356
71MP0004085_abnormal_heartbeat0.86453453
72MP0001177_atelectasis0.85715218
73MP0003121_genomic_imprinting0.84320383
74MP0005499_abnormal_olfactory_system0.83178020
75MP0005394_taste/olfaction_phenotype0.83178020
76MP0003123_paternal_imprinting0.81908827
77MP0004484_altered_response_of0.81898125
78MP0004233_abnormal_muscle_weight0.78481209
79MP0005535_abnormal_body_temperature0.77335779
80MP0000631_abnormal_neuroendocrine_gland0.73892251
81MP0003632_abnormal_nervous_system0.73672463
82MP0004742_abnormal_vestibular_system0.73551741
83MP0005167_abnormal_blood-brain_barrier0.73343960
84MP0003690_abnormal_glial_cell0.72613043
85MP0002752_abnormal_somatic_nervous0.71182747
86MP0004043_abnormal_pH_regulation0.71031782
87MP0003634_abnormal_glial_cell0.70233705
88MP0001664_abnormal_digestion0.69396014
89MP0002163_abnormal_gland_morphology0.66774159
90MP0006035_abnormal_mitochondrial_morpho0.65766200
91MP0004145_abnormal_muscle_electrophysio0.64794674
92MP0002090_abnormal_vision0.63595331
93MP0000604_amyloidosis0.62886293
94MP0003137_abnormal_impulse_conducting0.62605950
95MP0005253_abnormal_eye_physiology0.60982831
96MP0004036_abnormal_muscle_relaxation0.59669101
97MP0001943_abnormal_respiration0.59470100
98MP0002638_abnormal_pupillary_reflex0.58911120
99MP0005379_endocrine/exocrine_gland_phen0.58384475
100MP0000920_abnormal_myelination0.58344984
101MP0003075_altered_response_to0.57561732
102MP0001485_abnormal_pinna_reflex0.57273864
103MP0002332_abnormal_exercise_endurance0.56788830
104MP0005623_abnormal_meninges_morphology0.56027713
105MP0010769_abnormal_survival0.53241088
106MP0001346_abnormal_lacrimal_gland0.52308947
107MP0000026_abnormal_inner_ear0.52262709
108MP0010770_preweaning_lethality0.50916662
109MP0002082_postnatal_lethality0.50916662
110MP0010768_mortality/aging0.50819553
111MP0002234_abnormal_pharynx_morphology0.49736198
112MP0003956_abnormal_body_size0.49597034
113MP0001348_abnormal_lacrimal_gland0.48135319
114MP0004130_abnormal_muscle_cell0.46978170
115MP0003172_abnormal_lysosome_physiology0.45897743

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.35764362
2Atonic seizures (HP:0010819)7.03191085
3Febrile seizures (HP:0002373)6.15823967
4Myokymia (HP:0002411)6.14466632
5Focal seizures (HP:0007359)5.90866355
6Epileptic encephalopathy (HP:0200134)5.51059772
7Absence seizures (HP:0002121)5.34306232
8Dialeptic seizures (HP:0011146)4.61855455
9Generalized tonic-clonic seizures (HP:0002069)4.37124103
10Visual hallucinations (HP:0002367)4.34113790
11Progressive cerebellar ataxia (HP:0002073)4.12237579
12Hyperventilation (HP:0002883)3.90635630
13Pheochromocytoma (HP:0002666)3.47599962
14Progressive inability to walk (HP:0002505)3.47261242
15Abnormal eating behavior (HP:0100738)3.29880877
16Cerebral hypomyelination (HP:0006808)3.18566090
17Neuroendocrine neoplasm (HP:0100634)3.18393926
18Broad-based gait (HP:0002136)3.14490863
19Gaze-evoked nystagmus (HP:0000640)3.13906867
20Dysdiadochokinesis (HP:0002075)3.13238421
21Impaired vibration sensation in the lower limbs (HP:0002166)3.12590470
22Diplopia (HP:0000651)3.10813079
23Abnormality of binocular vision (HP:0011514)3.10813079
24Intention tremor (HP:0002080)3.03080802
25Abnormal hair whorl (HP:0010721)2.93525780
26Delusions (HP:0000746)2.92758721
27Abnormality of the corticospinal tract (HP:0002492)2.88203764
28Polyphagia (HP:0002591)2.86250632
29Neurofibrillary tangles (HP:0002185)2.85904383
30Action tremor (HP:0002345)2.82917723
31Impaired social interactions (HP:0000735)2.80664721
32Abnormal social behavior (HP:0012433)2.80664721
33Truncal ataxia (HP:0002078)2.78607748
34Ankle clonus (HP:0011448)2.78471681
35Poor eye contact (HP:0000817)2.78289237
36Anxiety (HP:0000739)2.78275004
37Depression (HP:0000716)2.72655659
38Dysmetria (HP:0001310)2.72244724
39Status epilepticus (HP:0002133)2.68166230
40Acute necrotizing encephalopathy (HP:0006965)2.68032834
41Epileptiform EEG discharges (HP:0011182)2.67909413
42Abnormal mitochondria in muscle tissue (HP:0008316)2.66197979
43Amblyopia (HP:0000646)2.63955598
44Failure to thrive in infancy (HP:0001531)2.63851987
45Inability to walk (HP:0002540)2.63021263
46Tetraplegia (HP:0002445)2.61002567
47Hemiplegia (HP:0002301)2.56334138
48Supranuclear gaze palsy (HP:0000605)2.54122209
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.53864221
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.53864221
51Urinary bladder sphincter dysfunction (HP:0002839)2.53192076
52Clonus (HP:0002169)2.52918491
53EEG with generalized epileptiform discharges (HP:0011198)2.52713130
54Scanning speech (HP:0002168)2.49785593
55Akinesia (HP:0002304)2.48904781
56Annular pancreas (HP:0001734)2.46933201
57Hemiparesis (HP:0001269)2.46870303
58Progressive macrocephaly (HP:0004481)2.41980280
59Gait imbalance (HP:0002141)2.41326068
60Hypsarrhythmia (HP:0002521)2.36710611
61Fetal akinesia sequence (HP:0001989)2.36048082
62Bradykinesia (HP:0002067)2.32711053
63Generalized myoclonic seizures (HP:0002123)2.32637131
64Excessive salivation (HP:0003781)2.29828264
65Drooling (HP:0002307)2.29828264
66Poor suck (HP:0002033)2.29648814
67Postural instability (HP:0002172)2.28015882
68Resting tremor (HP:0002322)2.26283067
69Urinary urgency (HP:0000012)2.22092124
70Specific learning disability (HP:0001328)2.21872343
71Genetic anticipation (HP:0003743)2.19113540
72Cerebral inclusion bodies (HP:0100314)2.17970332
73Congenital primary aphakia (HP:0007707)2.17840877
74Spastic tetraplegia (HP:0002510)2.17239821
75CNS hypomyelination (HP:0003429)2.16693937
76Morphological abnormality of the pyramidal tract (HP:0002062)2.16524097
77Impaired vibratory sensation (HP:0002495)2.15143122
78Limb dystonia (HP:0002451)2.14112523
79Spastic gait (HP:0002064)2.13785135
80Oligomenorrhea (HP:0000876)2.13405639
81Medial flaring of the eyebrow (HP:0010747)2.12995546
82Abnormality of the labia minora (HP:0012880)2.12146462
83Obstructive sleep apnea (HP:0002870)2.08933625
84Impaired smooth pursuit (HP:0007772)2.07740604
85Nephrogenic diabetes insipidus (HP:0009806)2.07612501
86Neuronal loss in central nervous system (HP:0002529)2.06975185
87Torticollis (HP:0000473)2.06768910
88Blue irides (HP:0000635)2.05963152
89Impaired pain sensation (HP:0007328)2.05711572
90Abnormality of pain sensation (HP:0010832)2.05711572
91Abnormality of the lower motor neuron (HP:0002366)2.04941482
92Absent speech (HP:0001344)2.03879013
93Spastic tetraparesis (HP:0001285)2.02705654
94Focal dystonia (HP:0004373)2.02015332
95Dysmetric saccades (HP:0000641)2.01920476
96Peripheral hypomyelination (HP:0007182)2.01295668
97Incomplete penetrance (HP:0003829)2.00612062
98Mitochondrial inheritance (HP:0001427)2.00396435
99Acute encephalopathy (HP:0006846)2.00034911
100Hyperthyroidism (HP:0000836)1.99803036
101Neoplasm of the peripheral nervous system (HP:0100007)1.98823292
102Apathy (HP:0000741)1.96523606
103Esotropia (HP:0000565)1.95596372
104Psychosis (HP:0000709)1.92309748
105Choreoathetosis (HP:0001266)1.92100945
106Hypoventilation (HP:0002791)1.91579768
107Mutism (HP:0002300)1.91161841
108Papilledema (HP:0001085)1.90508542
109Narrow nasal bridge (HP:0000446)1.90367775
110Cortical visual impairment (HP:0100704)1.90124341
111Generalized hypotonia (HP:0001290)1.87843042
112Split foot (HP:0001839)1.87050568
113Insidious onset (HP:0003587)1.85694436
114Termporal pattern (HP:0011008)1.85694436
115Lower limb muscle weakness (HP:0007340)1.85131393
116Protruding tongue (HP:0010808)1.84305998
117Amyotrophic lateral sclerosis (HP:0007354)1.84291661
118Rigidity (HP:0002063)1.84256977
119Abnormality of ocular smooth pursuit (HP:0000617)1.84070321
120Paraplegia (HP:0010550)1.83835835
121Increased circulating renin level (HP:0000848)1.82976957
122Unsteady gait (HP:0002317)1.82889384
123Stereotypic behavior (HP:0000733)1.82854604
124Sleep apnea (HP:0010535)1.81468413
125Ventricular fibrillation (HP:0001663)1.80714490
126Gait ataxia (HP:0002066)1.79034245
127Abnormal EKG (HP:0003115)1.78143633
128Craniofacial dystonia (HP:0012179)1.77216400
129Spastic paraplegia (HP:0001258)1.75691774
130Diminished motivation (HP:0000745)1.74714370
131Bundle branch block (HP:0011710)1.74699409
132Prolonged QT interval (HP:0001657)1.73827025
133Rapidly progressive (HP:0003678)1.72564145
134Hypoplasia of the corpus callosum (HP:0002079)1.67725047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.39483380
2MAP3K43.73636204
3MAP2K73.49559738
4CASK3.48083384
5MAP3K123.43236149
6EPHA43.24366365
7MAP3K93.21589583
8MINK12.37553438
9MAP2K42.27010111
10DAPK22.26627730
11MARK12.20832633
12NTRK22.08058704
13DAPK12.00153016
14PLK21.86248578
15NTRK11.82870382
16CDK191.68562946
17TSSK61.63588555
18RIPK41.63553851
19PAK61.62362184
20GRK51.56958575
21ARAF1.52068079
22TNIK1.45969237
23CDK51.42811278
24PRKCG1.41067133
25AKT31.39243529
26PNCK1.38461137
27PDK41.37437793
28PDK31.37437793
29NME11.33461758
30PRPF4B1.31124358
31KSR21.30337930
32CAMKK11.26270942
33CCNB11.23336501
34FRK1.23334667
35PRKD31.20078264
36FES1.19647895
37OXSR11.14112771
38MAPK131.11508859
39CAMK2A1.06899536
40SGK2231.06135452
41SGK4941.06135452
42ERBB41.03827559
43STK381.03116148
44UHMK11.02676391
45SGK21.02528555
46TNK21.00589559
47KSR10.99955501
48CAMK2B0.94196799
49SIK20.91501040
50MAP4K20.87843418
51CAMK40.86312253
52GRK70.84580414
53PRKCE0.84134091
54NEK10.81742845
55CDK180.81109959
56CDK140.77482621
57PRKCH0.76997555
58CDK150.76522277
59PDK20.75863420
60SGK30.73337736
61CAMKK20.72962739
62CAMK2D0.72903731
63CAMK10.68394632
64SGK10.65970963
65PINK10.65490642
66PTK2B0.65027213
67MAP3K130.64357995
68CDK11A0.64166144
69PAK30.64007106
70WNK30.63968382
71LATS20.63351831
72BMPR20.62534626
73MAP3K20.62082304
74BRAF0.61087870
75PKN10.61022769
76CAMK2G0.60863043
77MAPK120.59887005
78FGFR20.56115333
79PHKG20.56051966
80PHKG10.56051966
81STK110.55354148
82LIMK10.55213462
83TYRO30.55019921
84CSNK1A1L0.54725372
85FER0.54296934
86CSNK1G30.53646301
87SIK30.51944895
88RET0.51865487
89DYRK1A0.51627890
90PDK10.51346168
91MAPK100.49513833
92CSNK1G20.48964836
93DAPK30.48392238
94STK390.47567852
95RPS6KA30.46735535
96PDPK10.45654667
97MYLK0.44596460
98WNK10.44517322
99MARK20.43741939
100MAP3K10.42970542
101ROCK20.42774235
102BRSK10.42742062
103PRKCA0.42453564
104ALK0.41952258
105RAF10.41619994
106TRIM280.40750666
107CDK80.39578277
108ADRBK20.38674850
109BCR0.38306881
110NEK60.38287576
111PRKACA0.38038583
112PRKCZ0.37985158
113MAP2K10.37954089
114CDC42BPA0.37827775
115LMTK20.37680323
116FYN0.34977199
117DYRK20.34798779
118CSNK1D0.34676132
119CSNK1A10.34386129
120CSNK1G10.33590228
121PRKG10.32971984
122MAP3K110.32160197
123PRKCB0.31336193
124WNK40.29963843

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.28046468
2Synaptic vesicle cycle_Homo sapiens_hsa047214.04378648
3GABAergic synapse_Homo sapiens_hsa047273.00739872
4Collecting duct acid secretion_Homo sapiens_hsa049662.99040663
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86031270
6Morphine addiction_Homo sapiens_hsa050322.58541787
7Olfactory transduction_Homo sapiens_hsa047402.48697061
8Circadian entrainment_Homo sapiens_hsa047132.43562826
9Long-term potentiation_Homo sapiens_hsa047202.35704885
10Glutamatergic synapse_Homo sapiens_hsa047242.30666485
11Amphetamine addiction_Homo sapiens_hsa050312.16645647
12Taste transduction_Homo sapiens_hsa047422.01012639
13Dopaminergic synapse_Homo sapiens_hsa047281.98545437
14Salivary secretion_Homo sapiens_hsa049701.94038855
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91028109
16Insulin secretion_Homo sapiens_hsa049111.88362970
17Vibrio cholerae infection_Homo sapiens_hsa051101.86736661
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86188818
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83546559
20Oxidative phosphorylation_Homo sapiens_hsa001901.82019241
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79186503
22Serotonergic synapse_Homo sapiens_hsa047261.64129151
23Gastric acid secretion_Homo sapiens_hsa049711.59072917
24Long-term depression_Homo sapiens_hsa047301.53499788
25Cholinergic synapse_Homo sapiens_hsa047251.52127313
26Renin secretion_Homo sapiens_hsa049241.47263372
27Calcium signaling pathway_Homo sapiens_hsa040201.45227830
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43072410
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40573829
30Oxytocin signaling pathway_Homo sapiens_hsa049211.34593583
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33463855
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32846547
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32205045
34Cocaine addiction_Homo sapiens_hsa050301.31046902
35Parkinsons disease_Homo sapiens_hsa050121.27024779
36Cardiac muscle contraction_Homo sapiens_hsa042601.19186259
37Alzheimers disease_Homo sapiens_hsa050101.18594236
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17722699
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13433886
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09388316
41GnRH signaling pathway_Homo sapiens_hsa049121.08762750
42Gap junction_Homo sapiens_hsa045401.05829115
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00693168
44cAMP signaling pathway_Homo sapiens_hsa040240.99138232
45Type I diabetes mellitus_Homo sapiens_hsa049400.97861315
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94026822
47Estrogen signaling pathway_Homo sapiens_hsa049150.91874689
48Phototransduction_Homo sapiens_hsa047440.91057684
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89713936
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89656258
51Type II diabetes mellitus_Homo sapiens_hsa049300.86350570
52Huntingtons disease_Homo sapiens_hsa050160.84003446
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83178066
54Rheumatoid arthritis_Homo sapiens_hsa053230.82415610
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.80480857
56ErbB signaling pathway_Homo sapiens_hsa040120.80441518
57Pyruvate metabolism_Homo sapiens_hsa006200.77835863
58Axon guidance_Homo sapiens_hsa043600.76968796
59Melanogenesis_Homo sapiens_hsa049160.75259526
60Glioma_Homo sapiens_hsa052140.68355185
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67063179
62Pancreatic secretion_Homo sapiens_hsa049720.60766838
63Oocyte meiosis_Homo sapiens_hsa041140.60111918
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59551280
65Thyroid hormone synthesis_Homo sapiens_hsa049180.58373135
66MAPK signaling pathway_Homo sapiens_hsa040100.56581861
67Glucagon signaling pathway_Homo sapiens_hsa049220.55234282
68Butanoate metabolism_Homo sapiens_hsa006500.53385485
69Dilated cardiomyopathy_Homo sapiens_hsa054140.53029224
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49243082
71Phagosome_Homo sapiens_hsa041450.48963181
72beta-Alanine metabolism_Homo sapiens_hsa004100.47882177
73Arginine and proline metabolism_Homo sapiens_hsa003300.44324594
74Ether lipid metabolism_Homo sapiens_hsa005650.44187119
75Dorso-ventral axis formation_Homo sapiens_hsa043200.44044102
76Ras signaling pathway_Homo sapiens_hsa040140.42320091
77Inositol phosphate metabolism_Homo sapiens_hsa005620.42075002
78Arginine biosynthesis_Homo sapiens_hsa002200.41930119
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41625192
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.40635335
81Mineral absorption_Homo sapiens_hsa049780.40414312
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40096692
83Regulation of autophagy_Homo sapiens_hsa041400.38929011
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38514775
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38457863
86Vitamin B6 metabolism_Homo sapiens_hsa007500.38327551
87Fatty acid biosynthesis_Homo sapiens_hsa000610.34984217
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33072074
89Choline metabolism in cancer_Homo sapiens_hsa052310.32402635
90Alcoholism_Homo sapiens_hsa050340.31364363
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.30516882
92Nitrogen metabolism_Homo sapiens_hsa009100.30008871
93Rap1 signaling pathway_Homo sapiens_hsa040150.28350595
94Bile secretion_Homo sapiens_hsa049760.27464496
95Endocytosis_Homo sapiens_hsa041440.26933937
96VEGF signaling pathway_Homo sapiens_hsa043700.24631621
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.24349069
98Insulin signaling pathway_Homo sapiens_hsa049100.23987775
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23530656
100Prion diseases_Homo sapiens_hsa050200.22957215
101Ovarian steroidogenesis_Homo sapiens_hsa049130.22713187
102Histidine metabolism_Homo sapiens_hsa003400.22300463
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21330707
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20700846
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.20276570
106Circadian rhythm_Homo sapiens_hsa047100.20083323
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19659120
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19183702
109Wnt signaling pathway_Homo sapiens_hsa043100.19052714
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19033200
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17922793
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15405112
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14340991
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12860989
115Linoleic acid metabolism_Homo sapiens_hsa005910.11918982

Most similar genes based on co-expression Upload to Enrichr

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