KCNC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.00358046
2synaptic vesicle maturation (GO:0016188)5.92138122
3glutamate secretion (GO:0014047)5.50998436
4synaptic vesicle exocytosis (GO:0016079)5.25013982
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.23209429
6neuronal action potential propagation (GO:0019227)5.17213974
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.13346697
8locomotory exploration behavior (GO:0035641)5.03127324
9regulation of synaptic vesicle exocytosis (GO:2000300)5.00248836
10behavioral response to nicotine (GO:0035095)4.89340906
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83997030
12vocalization behavior (GO:0071625)4.79251496
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75439094
14regulation of synaptic vesicle transport (GO:1902803)4.48672755
15cellular potassium ion homeostasis (GO:0030007)4.42915431
16neuron cell-cell adhesion (GO:0007158)4.41178914
17regulation of glutamate receptor signaling pathway (GO:1900449)4.38981331
18neurotransmitter secretion (GO:0007269)4.37602495
19protein localization to synapse (GO:0035418)4.29858315
20sensory perception of smell (GO:0007608)4.17835148
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.17247574
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.09539398
23regulation of neuronal synaptic plasticity (GO:0048168)4.06168886
24sodium ion export (GO:0071436)4.03062316
25proline transport (GO:0015824)4.02937212
26activation of protein kinase A activity (GO:0034199)3.99660063
27exploration behavior (GO:0035640)3.98783360
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91778282
29gamma-aminobutyric acid transport (GO:0015812)3.87811790
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.81574368
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.80790894
32layer formation in cerebral cortex (GO:0021819)3.80133927
33cerebellar Purkinje cell differentiation (GO:0021702)3.77865575
34regulation of synapse structural plasticity (GO:0051823)3.76255611
35membrane depolarization during action potential (GO:0086010)3.72996095
36glutamate receptor signaling pathway (GO:0007215)3.71346298
37synaptic transmission, glutamatergic (GO:0035249)3.70106488
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.68014277
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63358816
40negative regulation of cytosolic calcium ion concentration (GO:0051481)3.60281181
41neurotransmitter-gated ion channel clustering (GO:0072578)3.59501301
42cell communication by electrical coupling (GO:0010644)3.58461764
43neurotransmitter transport (GO:0006836)3.57976726
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45511109
45neuron-neuron synaptic transmission (GO:0007270)3.42985930
46glycerophospholipid catabolic process (GO:0046475)3.40985307
47negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.38702488
48long-term memory (GO:0007616)3.38504367
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38303991
50neuromuscular process controlling posture (GO:0050884)3.36240854
51neuromuscular synaptic transmission (GO:0007274)3.34429956
52regulation of synaptic plasticity (GO:0048167)3.29914637
53regulation of neurotransmitter levels (GO:0001505)3.28434055
54* regulation of neurotransmitter secretion (GO:0046928)3.25044824
55regulation of postsynaptic membrane potential (GO:0060078)3.24480284
56synaptic vesicle endocytosis (GO:0048488)3.22701588
57cellular ketone body metabolic process (GO:0046950)3.20724998
58positive regulation of membrane potential (GO:0045838)3.20679576
59glycine transport (GO:0015816)3.20599925
60neuron recognition (GO:0008038)3.20545700
61dendritic spine morphogenesis (GO:0060997)3.19791848
62regulation of hippo signaling (GO:0035330)3.19699738
63positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.19394196
64insulin secretion (GO:0030073)3.16900804
65regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.16660019
66neuromuscular process controlling balance (GO:0050885)3.15147732
67regulation of vesicle fusion (GO:0031338)3.13392816
68membrane depolarization (GO:0051899)3.13254729
69potassium ion import (GO:0010107)3.13226622
70axonal fasciculation (GO:0007413)3.12605400
71potassium ion homeostasis (GO:0055075)3.11014295
72postsynaptic membrane organization (GO:0001941)3.10985278
73dopamine transport (GO:0015872)3.10939835
74cell migration in hindbrain (GO:0021535)3.08151278
75fucose catabolic process (GO:0019317)3.06686799
76L-fucose metabolic process (GO:0042354)3.06686799
77L-fucose catabolic process (GO:0042355)3.06686799
78dendrite morphogenesis (GO:0048813)3.05664389
79positive regulation of potassium ion transmembrane transport (GO:1901381)3.05650469
80positive regulation of synapse maturation (GO:0090129)3.05106608
81detection of light stimulus involved in visual perception (GO:0050908)3.03586841
82detection of light stimulus involved in sensory perception (GO:0050962)3.03586841
83nephron epithelium morphogenesis (GO:0072088)3.01448246
84nephron tubule morphogenesis (GO:0072078)3.01448246
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.01300550
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00928250
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00557814
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00288642
89* regulation of neurotransmitter transport (GO:0051588)2.99360332
90cAMP catabolic process (GO:0006198)2.98834614
91long-term synaptic potentiation (GO:0060291)2.97710777
92retinal cone cell development (GO:0046549)2.97292613
93vesicle transport along microtubule (GO:0047496)2.97205968
94regulation of cell communication by electrical coupling (GO:0010649)2.96953224
95indolalkylamine metabolic process (GO:0006586)2.96539561
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96134748
97transmission of nerve impulse (GO:0019226)2.93757419
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.93385864
99* synaptic transmission (GO:0007268)2.93283118
100reflex (GO:0060004)2.92769243
101positive regulation of neurotransmitter transport (GO:0051590)2.92148267
102regulation of sodium ion transmembrane transporter activity (GO:2000649)2.90770610
103cellular sodium ion homeostasis (GO:0006883)2.89740813
104catecholamine transport (GO:0051937)2.89714669
105chemosensory behavior (GO:0007635)2.89656390
106indole-containing compound catabolic process (GO:0042436)2.89085955
107indolalkylamine catabolic process (GO:0046218)2.89085955
108tryptophan catabolic process (GO:0006569)2.89085955
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88843392
110innervation (GO:0060384)2.87915378
111auditory behavior (GO:0031223)2.86902310
112mating behavior (GO:0007617)2.86577407
113response to auditory stimulus (GO:0010996)2.86110399
114regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84721591
115serotonin metabolic process (GO:0042428)2.84519491
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82904499
117* regulation of synaptic transmission (GO:0050804)2.81513107
118ketone body metabolic process (GO:1902224)2.81402856
119detection of calcium ion (GO:0005513)2.81020746
120cornea development in camera-type eye (GO:0061303)2.80823692
121membrane hyperpolarization (GO:0060081)2.80013654
122cyclic nucleotide catabolic process (GO:0009214)2.80007601
123regulation of voltage-gated calcium channel activity (GO:1901385)2.79587548
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79358800
125neuromuscular process (GO:0050905)2.79264083
126startle response (GO:0001964)2.78277316
127regulation of dendritic spine morphogenesis (GO:0061001)2.78189336
128positive regulation of neurotransmitter secretion (GO:0001956)2.77736111
129regulation of neurotransmitter uptake (GO:0051580)2.76565735
130snRNA transcription (GO:0009301)2.71554696
131signal peptide processing (GO:0006465)2.70505006
132kynurenine metabolic process (GO:0070189)2.68978450
133establishment of protein localization to Golgi (GO:0072600)2.67742393
134photoreceptor cell maintenance (GO:0045494)2.67486432
135indole-containing compound metabolic process (GO:0042430)2.65953412
136renal tubule morphogenesis (GO:0061333)2.65434084
137inositol phosphate catabolic process (GO:0071545)2.65111041
138primary amino compound metabolic process (GO:1901160)2.64837877
139response to pheromone (GO:0019236)2.63898668
140alanine transport (GO:0032328)2.62001588
141regulation of calcium ion-dependent exocytosis (GO:0017158)2.61265347
142positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.59510416
143neuronal action potential (GO:0019228)2.58109745
144spinal cord motor neuron differentiation (GO:0021522)2.53783654
145axoneme assembly (GO:0035082)2.52681699
146regulation of translation, ncRNA-mediated (GO:0045974)2.48246811
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48246811
148negative regulation of translation, ncRNA-mediated (GO:0040033)2.48246811
149regulation of respiratory system process (GO:0044065)2.47936763
150protein localization to cilium (GO:0061512)2.44446209
151positive regulation of meiosis (GO:0045836)2.43638566
152regulation of action potential (GO:0098900)2.42916296
153* potassium ion transmembrane transport (GO:0071805)2.42729677
154* cellular potassium ion transport (GO:0071804)2.42729677
155histone H3-K4 trimethylation (GO:0080182)2.42038180
156auditory receptor cell stereocilium organization (GO:0060088)2.40928475
157phosphorylated carbohydrate dephosphorylation (GO:0046838)2.40155012
158inositol phosphate dephosphorylation (GO:0046855)2.40155012
159polyol catabolic process (GO:0046174)2.39247938
160behavioral response to ethanol (GO:0048149)2.38968440
161tryptophan metabolic process (GO:0006568)2.38689725
162positive regulation of sodium ion transmembrane transport (GO:1902307)2.36879676
163cellular response to ATP (GO:0071318)2.36655180
164righting reflex (GO:0060013)2.36314666
165protein K11-linked deubiquitination (GO:0035871)2.35938914
166* potassium ion transport (GO:0006813)2.34537938
167regulation of gene silencing by RNA (GO:0060966)2.32359238
168regulation of posttranscriptional gene silencing (GO:0060147)2.32359238
169regulation of gene silencing by miRNA (GO:0060964)2.32359238
170regulation of acrosome reaction (GO:0060046)2.30127717
171action potential (GO:0001508)2.29843883
172calcium ion import (GO:0070509)2.29272736
173neurotransmitter metabolic process (GO:0042133)2.26575839
174glycosphingolipid biosynthetic process (GO:0006688)2.25955435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.21006754
2GBX2_23144817_ChIP-Seq_PC3_Human3.21053507
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04571951
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95973865
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89189538
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73571488
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73571488
8REST_21632747_ChIP-Seq_MESCs_Mouse2.65994987
9DROSHA_22980978_ChIP-Seq_HELA_Human2.62839206
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58741457
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54287499
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53930969
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53382510
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46275800
15VDR_22108803_ChIP-Seq_LS180_Human2.46000299
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43171432
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.39914225
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.32629746
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.24667480
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21899306
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.21592680
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19150869
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.08260950
24IGF1R_20145208_ChIP-Seq_DFB_Human2.06138538
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99921124
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97314391
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96805598
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96197888
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88445526
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87781634
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85928526
32* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80174383
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.76592655
34AR_21572438_ChIP-Seq_LNCaP_Human1.74203477
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.66306602
36BCAT_22108803_ChIP-Seq_LS180_Human1.63872236
37TAF15_26573619_Chip-Seq_HEK293_Human1.62849950
38FUS_26573619_Chip-Seq_HEK293_Human1.59362161
39ER_23166858_ChIP-Seq_MCF-7_Human1.58276296
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56160952
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.54306412
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52863111
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52781030
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51943073
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51735638
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43909718
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43780839
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43669691
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43652292
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38097696
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37903278
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32762972
53EWS_26573619_Chip-Seq_HEK293_Human1.32418637
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.31305058
55ZNF274_21170338_ChIP-Seq_K562_Hela1.30580740
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.29339720
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29302810
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27797615
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.27576673
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26945447
61* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26869058
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26532452
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25633712
64CBP_20019798_ChIP-Seq_JUKART_Human1.25515112
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25515112
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25394544
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24956997
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24755519
69TCF4_22108803_ChIP-Seq_LS180_Human1.21642605
70* KDM2B_26808549_Chip-Seq_K562_Human1.18808479
71AR_19668381_ChIP-Seq_PC3_Human1.18027453
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16807767
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16762822
74P300_19829295_ChIP-Seq_ESCs_Human1.16657474
75* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15944133
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15230374
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14928525
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14736971
79AR_25329375_ChIP-Seq_VCAP_Human1.13767133
80STAT3_23295773_ChIP-Seq_U87_Human1.13553673
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12969855
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.12361886
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12313636
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10844691
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10528196
86* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10085745
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.09688010
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09587727
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09043994
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07209027
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.07159622
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07012600
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.05447846
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.04577075
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.04540433
96NANOG_19829295_ChIP-Seq_ESCs_Human1.04413638
97SOX2_19829295_ChIP-Seq_ESCs_Human1.04413638
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.04349461
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04186671
100TP53_16413492_ChIP-PET_HCT116_Human1.03766102
101AHR_22903824_ChIP-Seq_MCF-7_Human1.03682978
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03110160
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.02745646
104TP53_22573176_ChIP-Seq_HFKS_Human1.02040675
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01920248
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.01804504
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01109473
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00664640
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00503742
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99675953
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99629746
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96480618
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.96079578
114TCF4_23295773_ChIP-Seq_U87_Human0.95288748
115RNF2_27304074_Chip-Seq_NSC_Mouse0.94878918
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94036997
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93916165
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91860781
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.91717324
120* CTCF_27219007_Chip-Seq_Bcells_Human0.91404465
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89955574
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89794785
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89529708
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89089053
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.88955641
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.88947967
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.86440352
128* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84834578
129RUNX2_22187159_ChIP-Seq_PCA_Human0.83926158
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83023292
131RXR_22108803_ChIP-Seq_LS180_Human0.82311699
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82191880
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82191880
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.81770838
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81746647
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.80642718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03284798
2MP0003880_abnormal_central_pattern4.31274260
3MP0004270_analgesia3.93221534
4MP0003635_abnormal_synaptic_transmissio3.92951212
5MP0001984_abnormal_olfaction3.49761556
6MP0009745_abnormal_behavioral_response3.14476127
7MP0001968_abnormal_touch/_nociception3.10027817
8MP0009046_muscle_twitch3.05329255
9MP0002063_abnormal_learning/memory/cond3.01992764
10MP0002064_seizures2.97973682
11MP0002734_abnormal_mechanical_nocicepti2.91272713
12MP0002272_abnormal_nervous_system2.59125998
13MP0002735_abnormal_chemical_nociception2.57991174
14MP0002572_abnormal_emotion/affect_behav2.53781530
15MP0005423_abnormal_somatic_nervous2.50138041
16MP0002822_catalepsy2.48056914
17MP0002736_abnormal_nociception_after2.44408511
18MP0001486_abnormal_startle_reflex2.36843635
19MP0004145_abnormal_muscle_electrophysio2.31838498
20MP0002138_abnormal_hepatobiliary_system2.26743613
21MP0004858_abnormal_nervous_system2.23601699
22MP0002733_abnormal_thermal_nociception2.16906272
23MP0008877_abnormal_DNA_methylation2.11203755
24MP0001970_abnormal_pain_threshold2.09406525
25MP0001501_abnormal_sleep_pattern2.08711523
26MP0003195_calcinosis2.07711160
27MP0004043_abnormal_pH_regulation2.05814906
28MP0002067_abnormal_sensory_capabilities2.01426891
29MP0002184_abnormal_innervation1.99813019
30MP0001440_abnormal_grooming_behavior1.99238485
31MP0008569_lethality_at_weaning1.97638771
32MP0008057_abnormal_DNA_replication1.96828424
33MP0000751_myopathy1.89781784
34MP0006276_abnormal_autonomic_nervous1.85191095
35MP0003329_amyloid_beta_deposits1.79647874
36MP0002876_abnormal_thyroid_physiology1.75684652
37MP0004811_abnormal_neuron_physiology1.75252555
38MP0000427_abnormal_hair_cycle1.69405689
39MP0005379_endocrine/exocrine_gland_phen1.65427901
40MP0002557_abnormal_social/conspecific_i1.65231801
41MP0009780_abnormal_chondrocyte_physiolo1.62404043
42MP0002254_reproductive_system_inflammat1.60985038
43MP0005174_abnormal_tail_pigmentation1.58215827
44MP0001986_abnormal_taste_sensitivity1.56782124
45MP0003879_abnormal_hair_cell1.55808837
46MP0002909_abnormal_adrenal_gland1.55554316
47MP0000778_abnormal_nervous_system1.55022923
48MP0000955_abnormal_spinal_cord1.54178181
49MP0000631_abnormal_neuroendocrine_gland1.53071277
50MP0002163_abnormal_gland_morphology1.52190282
51MP0005645_abnormal_hypothalamus_physiol1.49627600
52MP0005386_behavior/neurological_phenoty1.48573779
53MP0004924_abnormal_behavior1.48573779
54MP0005646_abnormal_pituitary_gland1.43790520
55MP0003045_fibrosis1.43656552
56MP0002882_abnormal_neuron_morphology1.43012287
57MP0003633_abnormal_nervous_system1.41312153
58MP0002066_abnormal_motor_capabilities/c1.38472505
59MP0004142_abnormal_muscle_tone1.35919347
60MP0004133_heterotaxia1.28610025
61MP0003646_muscle_fatigue1.27962923
62MP0002928_abnormal_bile_duct1.27311363
63MP0002693_abnormal_pancreas_physiology1.26584123
64MP0005253_abnormal_eye_physiology1.22485547
65MP0006072_abnormal_retinal_apoptosis1.20841715
66MP0005499_abnormal_olfactory_system1.20813367
67MP0005394_taste/olfaction_phenotype1.20813367
68MP0004885_abnormal_endolymph1.20170441
69MP0000749_muscle_degeneration1.18573457
70MP0001944_abnormal_pancreas_morphology1.17139914
71MP0003631_nervous_system_phenotype1.17084148
72MP0000747_muscle_weakness1.14355346
73MP0001905_abnormal_dopamine_level1.13174139
74MP0000230_abnormal_systemic_arterial1.11824686
75MP0001502_abnormal_circadian_rhythm1.11708973
76MP0003787_abnormal_imprinting1.10431499
77MP0005167_abnormal_blood-brain_barrier1.09417035
78MP0005670_abnormal_white_adipose1.07870829
79MP0005220_abnormal_exocrine_pancreas1.05981284
80MP0001756_abnormal_urination1.05051712
81MP0000383_abnormal_hair_follicle1.02760103
82MP0002152_abnormal_brain_morphology1.01990504
83MP0000538_abnormal_urinary_bladder1.01636592
84MP0004130_abnormal_muscle_cell0.99342311
85MP0002229_neurodegeneration0.98833954
86MP0002837_dystrophic_cardiac_calcinosis0.95915080
87MP0003122_maternal_imprinting0.95749466
88MP0001664_abnormal_digestion0.94944304
89MP0004233_abnormal_muscle_weight0.94336596
90MP0005448_abnormal_energy_balance0.93208546
91MP0010386_abnormal_urinary_bladder0.88673606
92MP0008874_decreased_physiological_sensi0.88607373
93MP0002752_abnormal_somatic_nervous0.87370695
94MP0001485_abnormal_pinna_reflex0.87230132
95MP0008872_abnormal_physiological_respon0.87003769
96MP0010329_abnormal_lipoprotein_level0.85399382
97MP0003634_abnormal_glial_cell0.85076719
98MP0005310_abnormal_salivary_gland0.84902872
99MP0002160_abnormal_reproductive_system0.84003214
100MP0004215_abnormal_myocardial_fiber0.83969376
101MP0002069_abnormal_eating/drinking_beha0.83275161
102MP0003075_altered_response_to0.82992121
103MP0001765_abnormal_ion_homeostasis0.82461368
104MP0005620_abnormal_muscle_contractility0.81990097
105MP0005332_abnormal_amino_acid0.81737831
106MP0002938_white_spotting0.80755659
107MP0002168_other_aberrant_phenotype0.79516165
108MP0004085_abnormal_heartbeat0.79028467
109MP0002102_abnormal_ear_morphology0.78945305
110MP0004742_abnormal_vestibular_system0.78091146
111MP0001299_abnormal_eye_distance/0.77771478
112MP0003632_abnormal_nervous_system0.77153025
113MP0005535_abnormal_body_temperature0.76771347
114MP0001529_abnormal_vocalization0.76586870
115MP0004036_abnormal_muscle_relaxation0.76400507
116MP0000013_abnormal_adipose_tissue0.76324594
117MP0001963_abnormal_hearing_physiology0.76053095
118MP0004484_altered_response_of0.75919068
119MP0002106_abnormal_muscle_physiology0.74847944
120MP0000604_amyloidosis0.74656395
121MP0000759_abnormal_skeletal_muscle0.73413744
122MP0002078_abnormal_glucose_homeostasis0.72823183
123MP0003953_abnormal_hormone_level0.72757632
124MP0005623_abnormal_meninges_morphology0.72672768
125MP0004147_increased_porphyrin_level0.72600287
126MP0005551_abnormal_eye_electrophysiolog0.72562474
127MP0004510_myositis0.72400531
128MP0002269_muscular_atrophy0.72006359
129MP0002638_abnormal_pupillary_reflex0.71817985
130MP0003690_abnormal_glial_cell0.71421766
131MP0003137_abnormal_impulse_conducting0.70347242
132MP0008961_abnormal_basal_metabolism0.70091863
133MP0005369_muscle_phenotype0.68209904
134MP0000920_abnormal_myelination0.67437712
135MP0008789_abnormal_olfactory_epithelium0.67252993
136MP0001177_atelectasis0.64203155
137MP0003283_abnormal_digestive_organ0.62783905
138MP0000569_abnormal_digit_pigmentation0.59090158
139MP0001188_hyperpigmentation0.58364400
140MP0004087_abnormal_muscle_fiber0.58123854

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.87780806
2Myokymia (HP:0002411)6.61966245
3Focal seizures (HP:0007359)5.36062901
4Visual hallucinations (HP:0002367)5.16113562
5Atonic seizures (HP:0010819)5.12399646
6Febrile seizures (HP:0002373)4.53813122
7Epileptic encephalopathy (HP:0200134)4.30250054
8Absence seizures (HP:0002121)4.27005676
9Action tremor (HP:0002345)4.22854927
10Progressive cerebellar ataxia (HP:0002073)4.10025105
11Generalized tonic-clonic seizures (HP:0002069)3.92757193
12Dialeptic seizures (HP:0011146)3.80390455
13Exercise-induced myalgia (HP:0003738)3.75841364
14Pancreatic cysts (HP:0001737)3.65070361
15Congenital stationary night blindness (HP:0007642)3.64403622
16Ankle clonus (HP:0011448)3.55291678
17Supranuclear gaze palsy (HP:0000605)3.50691918
18Nephronophthisis (HP:0000090)3.41705010
19Abnormality of midbrain morphology (HP:0002418)3.29868176
20Molar tooth sign on MRI (HP:0002419)3.29868176
21Impaired vibration sensation in the lower limbs (HP:0002166)3.18223197
22Pancreatic fibrosis (HP:0100732)3.17954559
23Decreased circulating renin level (HP:0003351)3.17319577
24Depression (HP:0000716)3.11658037
25Abnormality of the renal cortex (HP:0011035)3.11097249
26Abnormality of the renal medulla (HP:0100957)3.10090354
27True hermaphroditism (HP:0010459)3.07318703
28Type II lissencephaly (HP:0007260)3.06683762
29Chronic hepatic failure (HP:0100626)3.04852979
30Tubular atrophy (HP:0000092)3.04055525
31Abnormal drinking behavior (HP:0030082)3.01647962
32Polydipsia (HP:0001959)3.01647962
33Broad-based gait (HP:0002136)2.99274853
34Urinary bladder sphincter dysfunction (HP:0002839)2.99095680
35Attenuation of retinal blood vessels (HP:0007843)2.94745032
36Gaze-evoked nystagmus (HP:0000640)2.89842051
37Poor eye contact (HP:0000817)2.89178002
38Postural instability (HP:0002172)2.88972605
39Amblyopia (HP:0000646)2.88232429
40Myotonia (HP:0002486)2.86951208
41Ventricular fibrillation (HP:0001663)2.83579396
42Clumsiness (HP:0002312)2.83311457
43Dysdiadochokinesis (HP:0002075)2.83213307
44Anxiety (HP:0000739)2.77263668
45Dysmetria (HP:0001310)2.77252255
46Urinary urgency (HP:0000012)2.76733120
47Absent speech (HP:0001344)2.73068219
48Protruding tongue (HP:0010808)2.72646785
49Truncal ataxia (HP:0002078)2.72629948
50Abnormal eating behavior (HP:0100738)2.69636706
51Cystic liver disease (HP:0006706)2.67548400
52Mutism (HP:0002300)2.66877374
53Impaired social interactions (HP:0000735)2.64459667
54Abnormal social behavior (HP:0012433)2.64459667
55Torticollis (HP:0000473)2.64132972
56Muscle hypertrophy of the lower extremities (HP:0008968)2.53129996
57Hemiplegia (HP:0002301)2.53087051
58Large for gestational age (HP:0001520)2.52687490
59Abnormality of the lower motor neuron (HP:0002366)2.52570947
60Limb dystonia (HP:0002451)2.51566267
61Genetic anticipation (HP:0003743)2.49767038
62Exercise-induced muscle cramps (HP:0003710)2.45945468
63Pheochromocytoma (HP:0002666)2.44761659
64Inability to walk (HP:0002540)2.44220206
65Widely spaced teeth (HP:0000687)2.43975635
66Medial flaring of the eyebrow (HP:0010747)2.43802680
67Insidious onset (HP:0003587)2.43260681
68Termporal pattern (HP:0011008)2.43260681
69Spastic gait (HP:0002064)2.42192347
70Focal dystonia (HP:0004373)2.39734869
71Hyperventilation (HP:0002883)2.39447486
72Fetal akinesia sequence (HP:0001989)2.38750983
73Impaired smooth pursuit (HP:0007772)2.34734864
74Fair hair (HP:0002286)2.33809770
75Cerebellar dysplasia (HP:0007033)2.32510215
76Dysmetric saccades (HP:0000641)2.30367532
77Papilledema (HP:0001085)2.29716909
78Retinal dysplasia (HP:0007973)2.29637621
79Scanning speech (HP:0002168)2.27258223
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.26039673
81Hypoplasia of the fovea (HP:0007750)2.26039673
82Lower limb muscle weakness (HP:0007340)2.25988683
83Intention tremor (HP:0002080)2.23432037
84Agitation (HP:0000713)2.21991320
85Progressive inability to walk (HP:0002505)2.21177475
86Bundle branch block (HP:0011710)2.20764163
87Calf muscle hypertrophy (HP:0008981)2.20404026
88Craniofacial dystonia (HP:0012179)2.19466525
89Bradykinesia (HP:0002067)2.19306977
90Impaired vibratory sensation (HP:0002495)2.19201600
91Bony spicule pigmentary retinopathy (HP:0007737)2.18969751
92Increased corneal curvature (HP:0100692)2.17583393
93Keratoconus (HP:0000563)2.17583393
94Stomach cancer (HP:0012126)2.17555958
95Hemiparesis (HP:0001269)2.17298123
96Abolished electroretinogram (ERG) (HP:0000550)2.16065867
97Neoplasm of the adrenal cortex (HP:0100641)2.15561656
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15141752
99Neuroendocrine neoplasm (HP:0100634)2.14403910
100Difficulty running (HP:0009046)2.13498667
101Polyuria (HP:0000103)2.12216483
102Furrowed tongue (HP:0000221)2.11732424
103Megalencephaly (HP:0001355)2.10740966
104Hyperkalemia (HP:0002153)2.10558411
105Sudden death (HP:0001699)2.09476187
106Muscle stiffness (HP:0003552)2.08928309
107Bulbous nose (HP:0000414)2.04664067
108Gait imbalance (HP:0002141)2.04615480
109Epileptiform EEG discharges (HP:0011182)2.03563004
110Abnormality of binocular vision (HP:0011514)2.02994105
111Diplopia (HP:0000651)2.02994105
112Abnormality of the corticospinal tract (HP:0002492)2.02770570
113Distal arthrogryposis (HP:0005684)2.02518097
114Abnormal EKG (HP:0003115)2.01653131
115Excessive salivation (HP:0003781)2.01019912
116Drooling (HP:0002307)2.01019912
117Status epilepticus (HP:0002133)1.99712676
118Abnormality of ocular smooth pursuit (HP:0000617)1.99620511
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.99512453
120Hypothermia (HP:0002045)1.98981294
121Stereotypic behavior (HP:0000733)1.98638116
122Intellectual disability, progressive (HP:0006887)1.98393730
123Rapidly progressive (HP:0003678)1.97418045
124Cerebral inclusion bodies (HP:0100314)1.96085652
125Congenital sensorineural hearing impairment (HP:0008527)1.96049891
126Short chin (HP:0000331)1.95842390
127Abnormality of renin-angiotensin system (HP:0000847)1.94354050
128Muscle fiber inclusion bodies (HP:0100299)1.93750123
129Decreased central vision (HP:0007663)1.93689762
130Intestinal atresia (HP:0011100)1.93062129
131Incomplete penetrance (HP:0003829)1.93041281
132Anosmia (HP:0000458)1.92920605
133EEG with generalized epileptiform discharges (HP:0011198)1.91527646
134Hypoventilation (HP:0002791)1.90618973
135Neurofibrillary tangles (HP:0002185)1.89705365
136Shoulder girdle muscle weakness (HP:0003547)1.89385757
137Severe muscular hypotonia (HP:0006829)1.87989014
138Abnormal rod and cone electroretinograms (HP:0008323)1.87452068
139Congenital hepatic fibrosis (HP:0002612)1.87095663
140Syncope (HP:0001279)1.84510548
141Methylmalonic aciduria (HP:0012120)1.83627655
142Prolonged QT interval (HP:0001657)1.83185133
143Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82807831
144Congenital primary aphakia (HP:0007707)1.82539755
145Hypsarrhythmia (HP:0002521)1.81377143
146Annular pancreas (HP:0001734)1.80559414
147Rigidity (HP:0002063)1.80168299
148Generalized hypopigmentation of hair (HP:0011358)1.78312135
149Ketoacidosis (HP:0001993)1.76551086
150Renal cortical cysts (HP:0000803)1.76329075
151Polyphagia (HP:0002591)1.76327900
152Specific learning disability (HP:0001328)1.74348260
153Clonus (HP:0002169)1.74175854
154Abnormal urine output (HP:0012590)1.73865501
155Delusions (HP:0000746)1.72776765
156Insomnia (HP:0100785)1.72742957
157Generalized myoclonic seizures (HP:0002123)1.72584496
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.72038495
159Highly arched eyebrow (HP:0002553)1.71338236
160Genital tract atresia (HP:0001827)1.69474588
161Lissencephaly (HP:0001339)1.67980155
162Abnormality of renal excretion (HP:0011036)1.67143165
163Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65524233
164Abnormality of the fovea (HP:0000493)1.65258731
165Nephrogenic diabetes insipidus (HP:0009806)1.64778592
166Abnormality of the nasal septum (HP:0000419)1.64545167
167Tented upper lip vermilion (HP:0010804)1.63796206
168Urethral obstruction (HP:0000796)1.61936563
169Oligodactyly (hands) (HP:0001180)1.61921891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.51703337
2NTRK34.37887710
3MAP3K93.75292574
4ACVR1B3.12392530
5PHKG13.00785240
6PHKG23.00785240
7EPHA42.95489771
8MAP3K42.90409001
9BMPR1B2.81706459
10MINK12.72985297
11DAPK22.61496531
12MAP2K72.45918806
13MARK12.45410306
14MAP2K42.24309533
15PAK62.24006588
16WNK32.17802203
17MAP3K122.14422460
18ADRBK22.13046576
19KSR22.07356058
20MAP4K22.01212007
21NUAK11.94348330
22NTRK21.93055353
23NTRK11.88437681
24GRK11.86175327
25INSRR1.81671647
26PRKD31.81305483
27CAMKK11.77698250
28GRK51.76632309
29CASK1.72128726
30WNK41.64892674
31STK391.55955804
32ARAF1.54774288
33TLK11.50850716
34CDK191.49629093
35DAPK11.49351416
36PLK21.47418756
37STK381.46670817
38FGFR21.44056903
39CDK51.39847281
40LMTK21.33965620
41MAPKAPK51.33906293
42CAMKK21.30877077
43MAPK131.27099408
44TNIK1.23557573
45MAP3K21.23140105
46KSR11.21982259
47PRPF4B1.14675277
48TRPM71.13460871
49LATS21.13423354
50PINK11.12867702
51TAOK31.11496480
52ZAK1.09134755
53AKT31.08195451
54RIPK41.04434365
55MKNK21.04197811
56PAK31.04098117
57PNCK1.04097591
58* PRKCG1.02308242
59TIE10.99652859
60NME10.97595989
61SIK20.95866008
62CSNK1G10.95439263
63NLK0.95024503
64CAMK2A0.94594632
65CAMK10.93636088
66SGK2230.93408360
67SGK4940.93408360
68UHMK10.93343635
69CSNK1G30.90469196
70CAMK2B0.89923001
71HIPK20.89395972
72TYRO30.88946057
73NEK10.87886438
74PRKCH0.87318739
75STK110.86003086
76TAOK10.85693248
77CAMK2G0.83783661
78MAPKAPK30.82554634
79PRKAA20.82355449
80CDK180.81051642
81CSNK1A1L0.80840812
82MAP3K70.80096289
83CDK140.79849575
84CDK150.79355081
85PRKAA10.78944247
86RET0.76966271
87SGK20.76424695
88TGFBR10.76108362
89OXSR10.74629224
90ADRBK10.73228861
91OBSCN0.71465484
92CAMK1D0.71181337
93SGK30.70929099
94WNK10.70877493
95CAMK2D0.69293929
96STK160.68813372
97ALK0.68457415
98CDK11A0.67989405
99CSNK1G20.67157261
100TNK20.65696349
101MAP3K130.65399114
102TAF10.64367480
103STK38L0.63548715
104RIPK10.62870875
105CAMK1G0.62565579
106PIK3CG0.62522868
107FES0.62358570
108PTK2B0.62317912
109PDK10.62044427
110MARK20.60684670
111RAF10.60094244
112PDPK10.59107703
113MELK0.58933502
114MAP3K10.58540328
115STK30.58504280
116SGK10.58018662
117MAPK120.58010060
118PRKD20.56035273
119DYRK1A0.54620659
120PKN10.54034522
121CAMK40.51350456
122MAP2K60.49894723
123PRKG20.47736161
124RPS6KA30.47399501
125TEC0.46766765
126CDC42BPA0.46466719
127RPS6KA20.45761153
128MAP2K10.45495297
129PRKCI0.44597701
130FER0.44573882
131CSNK1A10.44304083
132PRKG10.43641330
133CSNK1D0.43115626
134MAPK100.40270636
135LIMK10.40127792
136PRKCZ0.39746750
137DAPK30.39710981
138PRKCE0.39644251
139CCNB10.39153398
140MAPK110.38746332
141MUSK0.37906801
142TRIM280.37106224
143PIK3CA0.36050587
144EEF2K0.35461941
145PRKACA0.34466690
146CHUK0.34062271
147ERBB30.33556845
148FYN0.32997053
149DMPK0.29611074
150ROCK20.29543196
151GRK70.28887169

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.94155290
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36001573
3Nicotine addiction_Homo sapiens_hsa050333.23254702
4Circadian entrainment_Homo sapiens_hsa047132.58531482
5GABAergic synapse_Homo sapiens_hsa047272.47618053
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43717547
7Long-term potentiation_Homo sapiens_hsa047202.39942627
8Glutamatergic synapse_Homo sapiens_hsa047242.36911521
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26627482
10Morphine addiction_Homo sapiens_hsa050322.24592772
11Amphetamine addiction_Homo sapiens_hsa050312.22950821
12Salivary secretion_Homo sapiens_hsa049702.16135725
13Insulin secretion_Homo sapiens_hsa049112.12320764
14Gastric acid secretion_Homo sapiens_hsa049712.03431559
15Dopaminergic synapse_Homo sapiens_hsa047282.03227352
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96383981
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.95523222
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83656698
19Cholinergic synapse_Homo sapiens_hsa047251.83401254
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81121856
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78762381
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78632944
23Butanoate metabolism_Homo sapiens_hsa006501.77920248
24Taste transduction_Homo sapiens_hsa047421.75708814
25ABC transporters_Homo sapiens_hsa020101.73419963
26Oxytocin signaling pathway_Homo sapiens_hsa049211.68729251
27Linoleic acid metabolism_Homo sapiens_hsa005911.68422906
28Ether lipid metabolism_Homo sapiens_hsa005651.65810463
29Calcium signaling pathway_Homo sapiens_hsa040201.63993494
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63751034
31Renin secretion_Homo sapiens_hsa049241.53087210
32GnRH signaling pathway_Homo sapiens_hsa049121.52746116
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49605506
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47337745
35Collecting duct acid secretion_Homo sapiens_hsa049661.46338229
36Serotonergic synapse_Homo sapiens_hsa047261.44720478
37Long-term depression_Homo sapiens_hsa047301.41832091
38Cocaine addiction_Homo sapiens_hsa050301.33290990
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31880058
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31800675
41cAMP signaling pathway_Homo sapiens_hsa040241.31472023
42Cardiac muscle contraction_Homo sapiens_hsa042601.29595550
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24881936
44Selenocompound metabolism_Homo sapiens_hsa004501.24805203
45Gap junction_Homo sapiens_hsa045401.21725607
46Nitrogen metabolism_Homo sapiens_hsa009101.12943280
47Estrogen signaling pathway_Homo sapiens_hsa049151.12612956
48Tryptophan metabolism_Homo sapiens_hsa003801.12496990
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09615820
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08953796
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06593205
52Lysine degradation_Homo sapiens_hsa003101.05795124
53Type II diabetes mellitus_Homo sapiens_hsa049301.03652083
54Vibrio cholerae infection_Homo sapiens_hsa051101.03127621
55Glioma_Homo sapiens_hsa052141.02764728
56Melanogenesis_Homo sapiens_hsa049161.01339539
57Dilated cardiomyopathy_Homo sapiens_hsa054140.99367664
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97460522
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.94241840
60Sphingolipid metabolism_Homo sapiens_hsa006000.91775185
61Thyroid hormone synthesis_Homo sapiens_hsa049180.90801561
62Axon guidance_Homo sapiens_hsa043600.90504387
63ErbB signaling pathway_Homo sapiens_hsa040120.88427256
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87610743
65Pancreatic secretion_Homo sapiens_hsa049720.87481241
66Glycerolipid metabolism_Homo sapiens_hsa005610.85222918
67Glucagon signaling pathway_Homo sapiens_hsa049220.84207805
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81010081
69Dorso-ventral axis formation_Homo sapiens_hsa043200.81005165
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80833544
71Oocyte meiosis_Homo sapiens_hsa041140.80201792
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79314163
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.79200648
74Phototransduction_Homo sapiens_hsa047440.77078478
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.75644180
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75382783
77Bile secretion_Homo sapiens_hsa049760.74314149
78Homologous recombination_Homo sapiens_hsa034400.73287702
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73155738
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68298085
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.67966685
82Insulin signaling pathway_Homo sapiens_hsa049100.67836686
83MAPK signaling pathway_Homo sapiens_hsa040100.67404923
84beta-Alanine metabolism_Homo sapiens_hsa004100.63920420
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.63090667
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61351428
87Vitamin B6 metabolism_Homo sapiens_hsa007500.60871354
88Histidine metabolism_Homo sapiens_hsa003400.60384743
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59749677
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58818920
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58676050
92Circadian rhythm_Homo sapiens_hsa047100.57756694
93Arachidonic acid metabolism_Homo sapiens_hsa005900.57238555
94Choline metabolism in cancer_Homo sapiens_hsa052310.57015847
95Retinol metabolism_Homo sapiens_hsa008300.54456002
96VEGF signaling pathway_Homo sapiens_hsa043700.54106895
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53630975
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53006484
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51168299
100RNA polymerase_Homo sapiens_hsa030200.49245518
101Ras signaling pathway_Homo sapiens_hsa040140.48917513
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48791218
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47869508
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47432365
105Regulation of autophagy_Homo sapiens_hsa041400.46985215
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46815500
107Rap1 signaling pathway_Homo sapiens_hsa040150.46265381
108Basal transcription factors_Homo sapiens_hsa030220.45969453
109Alzheimers disease_Homo sapiens_hsa050100.45404899
110Ovarian steroidogenesis_Homo sapiens_hsa049130.45273535
111Fatty acid biosynthesis_Homo sapiens_hsa000610.44462311
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44452609
113mTOR signaling pathway_Homo sapiens_hsa041500.44329977
114Fanconi anemia pathway_Homo sapiens_hsa034600.43854177
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.43794435
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43604564
117Propanoate metabolism_Homo sapiens_hsa006400.43224020
118Chemical carcinogenesis_Homo sapiens_hsa052040.42680047
119Endocytosis_Homo sapiens_hsa041440.41818820
120Alcoholism_Homo sapiens_hsa050340.40622057
121Inositol phosphate metabolism_Homo sapiens_hsa005620.39490548
122Mineral absorption_Homo sapiens_hsa049780.36891360
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36711776
124Hedgehog signaling pathway_Homo sapiens_hsa043400.36587870
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.34960860
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34861519
127Prion diseases_Homo sapiens_hsa050200.34097263
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32941906
129Endometrial cancer_Homo sapiens_hsa052130.32073623
130Sulfur metabolism_Homo sapiens_hsa009200.31907632
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.31694704
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.31411048
133Caffeine metabolism_Homo sapiens_hsa002320.30821910
134Wnt signaling pathway_Homo sapiens_hsa043100.27915908
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.26366803
136Renal cell carcinoma_Homo sapiens_hsa052110.26197645
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25919888
138Oxidative phosphorylation_Homo sapiens_hsa001900.24222031
139Chemokine signaling pathway_Homo sapiens_hsa040620.22635310
140Tight junction_Homo sapiens_hsa045300.22623457

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