KCND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)6.10265555
2detection of temperature stimulus (GO:0016048)5.92639161
3detection of temperature stimulus involved in sensory perception (GO:0050961)5.79448327
4detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.79448327
5negative regulation of dendrite morphogenesis (GO:0050774)5.73976115
6response to peptidoglycan (GO:0032494)5.70749600
7regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.70592514
8neuronal action potential (GO:0019228)5.59030227
9peripheral nervous system neuron development (GO:0048935)5.39630253
10negative regulation of erythrocyte differentiation (GO:0045647)5.21305229
11neuronal action potential propagation (GO:0019227)5.17410525
12membrane depolarization during action potential (GO:0086010)5.14389407
13response to muramyl dipeptide (GO:0032495)5.07124419
14behavioral response to pain (GO:0048266)5.02574193
15cell migration in hindbrain (GO:0021535)5.01595494
16negative regulation of calcium ion transport into cytosol (GO:0010523)4.98246107
17proline transport (GO:0015824)4.44820575
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35746293
19synaptic vesicle maturation (GO:0016188)4.28060280
20negative regulation of dendrite development (GO:2000171)4.22502187
21response to pain (GO:0048265)4.19541512
22cellular potassium ion homeostasis (GO:0030007)4.14705067
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12028312
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.12028312
25modulation by symbiont of host immune response (GO:0052553)4.12028312
26positive regulation by symbiont of host defense response (GO:0052509)4.12028312
27modulation by symbiont of host defense response (GO:0052031)4.12028312
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12028312
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.11496590
30positive regulation of synaptic transmission, GABAergic (GO:0032230)4.05100911
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03429405
32synaptic vesicle exocytosis (GO:0016079)4.00001883
33sodium ion export (GO:0071436)3.96670281
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.95701887
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.89469778
36glutamate secretion (GO:0014047)3.89442999
37histone H3-K36 demethylation (GO:0070544)3.87233922
38protein localization to synapse (GO:0035418)3.85589705
39cell communication involved in cardiac conduction (GO:0086065)3.82096517
40cell communication by electrical coupling (GO:0010644)3.78239885
41urinary tract smooth muscle contraction (GO:0014848)3.77563688
42positive regulation of gamma-delta T cell activation (GO:0046645)3.77469205
43regulation of synaptic vesicle exocytosis (GO:2000300)3.75630550
44innervation (GO:0060384)3.71225424
45calcium-mediated signaling using intracellular calcium source (GO:0035584)3.70846087
46mannose metabolic process (GO:0006013)3.67379967
47negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.65814414
48negative regulation of cation channel activity (GO:2001258)3.58925434
49neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.57193447
50regulation of interferon-beta biosynthetic process (GO:0045357)3.53566382
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.52845662
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.50843273
53membrane repolarization (GO:0086009)3.47088167
54cerebellar Purkinje cell differentiation (GO:0021702)3.45993003
55cellular sodium ion homeostasis (GO:0006883)3.43964107
56negative regulation of homotypic cell-cell adhesion (GO:0034111)3.41574169
57gamma-aminobutyric acid transport (GO:0015812)3.41349461
58positive regulation of cardiac muscle hypertrophy (GO:0010613)3.38929369
59positive regulation of muscle hypertrophy (GO:0014742)3.38929369
60axon cargo transport (GO:0008088)3.37907663
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.37761311
62detection of molecule of bacterial origin (GO:0032490)3.37638379
63regulation of platelet aggregation (GO:0090330)3.37043532
64neuron cell-cell adhesion (GO:0007158)3.36630697
65sodium ion transmembrane transport (GO:0035725)3.36509349
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36482789
67regulation of T-helper 2 cell differentiation (GO:0045628)3.36080746
68detection of mechanical stimulus involved in sensory perception (GO:0050974)3.35341787
69action potential (GO:0001508)3.34164841
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32795236
71negative regulation of cell killing (GO:0031342)3.32795236
72retinal ganglion cell axon guidance (GO:0031290)3.31496101
73potassium ion export (GO:0071435)3.30115853
74macrophage activation involved in immune response (GO:0002281)3.28370730
75neuromuscular process controlling posture (GO:0050884)3.23012396
76regulation of synaptic vesicle transport (GO:1902803)3.22415906
77detection of other organism (GO:0098543)3.20749302
78response to water (GO:0009415)3.20617630
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20244322
80germinal center formation (GO:0002467)3.20078442
81regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.19664139
82cellular extravasation (GO:0045123)3.18842808
83defense response to protozoan (GO:0042832)3.18769726
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17256686
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16938805
86negative regulation of microtubule polymerization (GO:0031115)3.16893078
87regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.16139586
88response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14046625
89response to host (GO:0075136)3.14046625
90response to host defenses (GO:0052200)3.14046625
91vesicle transport along microtubule (GO:0047496)3.13414243
92establishment of mitochondrion localization (GO:0051654)3.13256787
93modulation by virus of host process (GO:0019054)3.13046736
94leukocyte aggregation (GO:0070486)3.12235056
95negative regulation of toll-like receptor signaling pathway (GO:0034122)3.12212476
96adenosine receptor signaling pathway (GO:0001973)3.10894490
97positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10295756
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08932747
99response to host immune response (GO:0052572)3.08932747
100membrane depolarization (GO:0051899)3.08623582
101positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07497333
102detection of bacterium (GO:0016045)3.06694025
103organelle transport along microtubule (GO:0072384)3.03872607
104neuromuscular synaptic transmission (GO:0007274)3.03170701
105regulation of neuron projection regeneration (GO:0070570)3.02456751
106regulation of axon regeneration (GO:0048679)3.02456751
107enteric nervous system development (GO:0048484)3.02243223
108detection of external biotic stimulus (GO:0098581)2.99679964
109modulation by symbiont of host cellular process (GO:0044068)2.99642081
110regulation of amyloid precursor protein catabolic process (GO:1902991)2.98860695
111positive regulation of potassium ion transmembrane transport (GO:1901381)2.98363418
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.97776479
113antigen processing and presentation of endogenous antigen (GO:0019883)2.97694322
114regulation of ARF GTPase activity (GO:0032312)2.97487318
115histone demethylation (GO:0016577)2.97308514
116lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96074092
117regulation of NFAT protein import into nucleus (GO:0051532)2.95004519
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94702361
119histone lysine demethylation (GO:0070076)2.94236893
120negative regulation of interleukin-12 production (GO:0032695)2.93970198
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.89117973
122regulation of histone H3-K27 methylation (GO:0061085)2.88144975
123negative regulation of heart rate (GO:0010459)2.88131736
124negative regulation of histone methylation (GO:0031061)2.87854245
125purinergic nucleotide receptor signaling pathway (GO:0035590)2.87632503
126locomotory exploration behavior (GO:0035641)2.87183653
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87119392
128mitochondrion transport along microtubule (GO:0047497)2.87119392
129calcium ion-dependent exocytosis (GO:0017156)2.86876751
130positive regulation of amino acid transport (GO:0051957)2.85851884
131negative regulation of sodium ion transport (GO:0010766)2.85624960
132response to protozoan (GO:0001562)2.84020923
133negative regulation of cell size (GO:0045792)2.82157734
134neutrophil activation involved in immune response (GO:0002283)2.80650352
135regulation of neurotransmitter secretion (GO:0046928)2.80318247
136neurotransmitter secretion (GO:0007269)2.80109284
137type I interferon signaling pathway (GO:0060337)2.79568375
138cellular response to type I interferon (GO:0071357)2.79568375
139response to type I interferon (GO:0034340)2.78811963
140synaptic transmission, glutamatergic (GO:0035249)2.77996643
141alanine transport (GO:0032328)2.77598419
142regulation of ARF protein signal transduction (GO:0032012)2.77264377
143multicellular organismal response to stress (GO:0033555)2.76405042
144synaptic vesicle docking involved in exocytosis (GO:0016081)2.75771999
145* potassium ion transmembrane transport (GO:0071805)2.75384235
146* cellular potassium ion transport (GO:0071804)2.75384235
147regulation of respiratory system process (GO:0044065)2.75378308
148regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73066115
149negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.72968209
150regulation of leukocyte degranulation (GO:0043300)2.72534934
151vocalization behavior (GO:0071625)2.72403523
152ionotropic glutamate receptor signaling pathway (GO:0035235)2.71999418
153intracellular estrogen receptor signaling pathway (GO:0030520)2.70305686
154response to laminar fluid shear stress (GO:0034616)2.69912693
155detection of biotic stimulus (GO:0009595)2.69166106
156NIK/NF-kappaB signaling (GO:0038061)2.68795037
157regulation of vesicle fusion (GO:0031338)2.68766006
158sensory perception of pain (GO:0019233)2.68409626
159cellular response to virus (GO:0098586)2.68057458
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.66385151
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.65834324
162protein dealkylation (GO:0008214)2.65632511
163protein demethylation (GO:0006482)2.65632511
164negative regulation of ion transmembrane transporter activity (GO:0032413)2.65359966
165regulation of cell communication by electrical coupling (GO:0010649)2.64941764
166antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64472683
167positive regulation of histone deacetylation (GO:0031065)2.63564629
168positive thymic T cell selection (GO:0045059)2.63001312
169positive regulation of Rap GTPase activity (GO:0032854)2.62568556
170protein retention in ER lumen (GO:0006621)2.62300653
171regulation of chromatin binding (GO:0035561)2.59640468
172stress fiber assembly (GO:0043149)2.59092888
173histone H4 deacetylation (GO:0070933)2.58922403
174regulation of gamma-delta T cell activation (GO:0046643)2.58383241
175signal complex assembly (GO:0007172)2.57557643
176maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55258800
177regulation of mast cell degranulation (GO:0043304)2.54899763
178regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54465149
1793-UTR-mediated mRNA stabilization (GO:0070935)2.54219608
180positive regulation of T cell apoptotic process (GO:0070234)2.52607369
181B cell receptor signaling pathway (GO:0050853)2.51111474
182regulation of interleukin-2 biosynthetic process (GO:0045076)2.48627304
183regulation of regulated secretory pathway (GO:1903305)2.44495374
184positive regulation of gene expression, epigenetic (GO:0045815)2.43406974
185myeloid cell activation involved in immune response (GO:0002275)2.42714191
186positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.41876684
187megakaryocyte development (GO:0035855)2.40710853
188negative regulation of interleukin-8 production (GO:0032717)2.40452856
189positive regulation of protein deacetylation (GO:0090312)2.39837618
190thymic T cell selection (GO:0045061)2.39640361
191peptidyl-tyrosine autophosphorylation (GO:0038083)2.39055326
192protein localization to endosome (GO:0036010)2.37599426
193positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.36548820
194tolerance induction (GO:0002507)2.35218815
195positive regulation of interferon-alpha production (GO:0032727)2.35156439
196positive regulation of B cell differentiation (GO:0045579)2.35111173
197response to interferon-alpha (GO:0035455)2.34043576
198histone H3-K9 demethylation (GO:0033169)2.33734854
199leukocyte migration involved in inflammatory response (GO:0002523)2.33623251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61156490
2GBX2_23144817_ChIP-Seq_PC3_Human3.66281462
3VDR_21846776_ChIP-Seq_THP-1_Human3.39933123
4MYC_22102868_ChIP-Seq_BL_Human3.21565663
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12251821
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.93073714
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92397815
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84474836
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70210680
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70210680
11LXR_22292898_ChIP-Seq_THP-1_Human2.67267915
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64058745
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57078858
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51030314
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50622154
16REST_21632747_ChIP-Seq_MESCs_Mouse2.50250425
17TCF7_22412390_ChIP-Seq_EML_Mouse2.48603936
18KDM2B_26808549_Chip-Seq_DND41_Human2.47639152
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.46016343
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43430309
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38925612
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38503593
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.35643587
24VDR_24763502_ChIP-Seq_THP-1_Human2.34819051
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34531233
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31258973
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.28762037
28MAF_26560356_Chip-Seq_TH1_Human2.28475627
29STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26685006
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22601196
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21358629
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.16919177
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10826283
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.09615706
35UTX_26944678_Chip-Seq_JUKART_Human2.09482286
36MAF_26560356_Chip-Seq_TH2_Human2.09439005
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08291795
38EZH2_27294783_Chip-Seq_ESCs_Mouse2.01102857
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98522585
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98302141
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.97879656
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91133046
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89287227
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84732895
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.83290366
46RACK7_27058665_Chip-Seq_MCF-7_Human1.82393747
47SMAD4_21799915_ChIP-Seq_A2780_Human1.81444098
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.81146971
49* P68_20966046_ChIP-Seq_HELA_Human1.80904713
50TAF15_26573619_Chip-Seq_HEK293_Human1.80899368
51VDR_22108803_ChIP-Seq_LS180_Human1.79040212
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76877391
53DROSHA_22980978_ChIP-Seq_HELA_Human1.76531546
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72032839
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.70271845
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.69557884
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.69104511
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.66859470
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64885132
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62764026
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61490838
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61466418
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60259988
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58736360
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57473762
66NCOR1_26117541_ChIP-Seq_K562_Human1.55748779
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54520925
68SMC4_20622854_ChIP-Seq_HELA_Human1.53178751
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52950199
70SPI1_23127762_ChIP-Seq_K562_Human1.51433074
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.51330425
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51181118
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48805806
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.48661966
75P300_19829295_ChIP-Seq_ESCs_Human1.46624964
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45374381
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44822928
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43704642
79* ELF1_20517297_ChIP-Seq_JURKAT_Human1.43587642
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42544483
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42348455
82BCOR_27268052_Chip-Seq_Bcells_Human1.40960802
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40549488
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40419726
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39275940
86AR_21572438_ChIP-Seq_LNCaP_Human1.38028335
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35883748
88CREB1_26743006_Chip-Seq_LNCaP_Human1.34596282
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34558835
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33903104
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33712395
92RNF2_27304074_Chip-Seq_NSC_Mouse1.31422414
93STAT3_23295773_ChIP-Seq_U87_Human1.30335478
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30147378
95SPI1_23547873_ChIP-Seq_NB4_Human1.29695675
96AHR_22903824_ChIP-Seq_MCF-7_Human1.28701160
97* GATA1_19941827_ChIP-Seq_MEL_Mouse1.27507469
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27305769
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.26805794
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26488844
101* BCL6_27268052_Chip-Seq_Bcells_Human1.24926194
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24899861
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24394589
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24101549
105IGF1R_20145208_ChIP-Seq_DFB_Human1.24020634
106CIITA_25753668_ChIP-Seq_RAJI_Human1.23893982
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23754615
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23728246
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22669353
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22119511
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.22073506
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21953706
113AR_25329375_ChIP-Seq_VCAP_Human1.21229266
114SCL_19346495_ChIP-Seq_HPC-7_Human1.21069338
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.20764670
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20236064
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.20200263
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19865835
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19635150
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19223217
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18229103
122MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18021358
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17966932
124PHF8_20622854_ChIP-Seq_HELA_Human1.17500430
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17450630
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17450630
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17450630
128E2F1_20622854_ChIP-Seq_HELA_Human1.17331372
129KDM2B_26808549_Chip-Seq_K562_Human1.17192775
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17035094
131CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16952059
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16923463
133TP53_20018659_ChIP-ChIP_R1E_Mouse1.16263031
134ESR2_21235772_ChIP-Seq_MCF-7_Human1.16141874
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15622373
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14778695
137ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14570508
138BCAT_22108803_ChIP-Seq_LS180_Human1.14216435
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13260084
140* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12996561
141CTCF_27219007_Chip-Seq_Bcells_Human1.12540519
142SMAD4_21741376_ChIP-Seq_HESCs_Human1.11848952
143TP53_22127205_ChIP-Seq_IMR90_Human1.11371147
144P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11226906
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10257052
146* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09316352
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08890316
148CTCF_21964334_Chip-Seq_Bcells_Human1.08845485
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08748698
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08349996
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07822701
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07361613
153P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07194946
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07127733
155RING1B_27294783_Chip-Seq_ESCs_Mouse1.07026924
156RING1B_27294783_Chip-Seq_NPCs_Mouse1.06751938
157RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06699314
158TET1_21490601_ChIP-Seq_MESCs_Mouse1.06221386
159AR_19668381_ChIP-Seq_PC3_Human1.05657158
160IRF8_27001747_Chip-Seq_BMDM_Mouse1.05472309
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04618049
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03966251
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03677609
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03636709
165MYB_26560356_Chip-Seq_TH1_Human1.03587632
166CBX2_27304074_Chip-Seq_ESCs_Mouse1.03040753
167ATF3_27146783_Chip-Seq_COLON_Human1.02707232
168* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01998821
169YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01895061
170WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01782308
171MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01726544
172SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01428166
173RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01154075
174ARNT_22903824_ChIP-Seq_MCF-7_Human1.01045098
175SMAD3_21741376_ChIP-Seq_ESCs_Human1.00005569
176* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99488783
177TCF4_23295773_ChIP-Seq_U87_Human0.99238619
178PIAS1_25552417_ChIP-Seq_VCAP_Human0.95926545
179PRDM14_20953172_ChIP-Seq_ESCs_Human0.95839184
180ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94702274
181UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93042108
182SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91427608
183LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91418876
184DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90500218
185SMAD3_21741376_ChIP-Seq_HESCs_Human0.89687103
186JUN_21703547_ChIP-Seq_K562_Human0.88770912
187STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88371052
188TCF4_22108803_ChIP-Seq_LS180_Human0.88059205
189TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87656915
190RUNX2_22187159_ChIP-Seq_PCA_Human0.87062841
191ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86918282
192ESR1_20079471_ChIP-ChIP_T-47D_Human0.86569301
193SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85483539
194ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84063793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.61655206
2MP0001968_abnormal_touch/_nociception6.15025674
3MP0002736_abnormal_nociception_after5.78177713
4MP0004270_analgesia4.82751072
5MP0001986_abnormal_taste_sensitivity4.38787042
6MP0004858_abnormal_nervous_system4.16435120
7MP0002733_abnormal_thermal_nociception3.99436313
8MP0009278_abnormal_bone_marrow3.96876785
9MP0002734_abnormal_mechanical_nocicepti3.89425703
10MP0003436_decreased_susceptibility_to3.71302350
11MP0004859_abnormal_synaptic_plasticity3.57579352
12MP0006276_abnormal_autonomic_nervous3.47650289
13MP0001970_abnormal_pain_threshold3.40216952
14MP0003303_peritoneal_inflammation3.37195857
15MP0003705_abnormal_hypodermis_morpholog3.20180400
16MP0002272_abnormal_nervous_system2.46822088
17MP0003635_abnormal_synaptic_transmissio2.46788624
18MP0003300_gastrointestinal_ulcer2.46763291
19MP0003724_increased_susceptibility_to2.45149366
20MP0005058_abnormal_lysosome_morphology2.38747938
21MP0005076_abnormal_cell_differentiation2.28088353
22MP0003880_abnormal_central_pattern2.27744996
23MP0002419_abnormal_innate_immunity2.24256516
24MP0002067_abnormal_sensory_capabilities2.18526149
25MP0005423_abnormal_somatic_nervous2.15196748
26MP0002184_abnormal_innervation2.13555814
27MP0008004_abnormal_stomach_pH2.13056886
28MP0003183_abnormal_peptide_metabolism2.11631964
29MP0005000_abnormal_immune_tolerance2.02710544
30MP0001835_abnormal_antigen_presentation2.01844613
31MP0009046_muscle_twitch2.00855412
32MP0005025_abnormal_response_to2.00121429
33MP0002064_seizures1.94866928
34MP0001545_abnormal_hematopoietic_system1.93824294
35MP0005397_hematopoietic_system_phenotyp1.93824294
36MP0002063_abnormal_learning/memory/cond1.87124146
37MP0009745_abnormal_behavioral_response1.85224589
38MP0001790_abnormal_immune_system1.83924591
39MP0005387_immune_system_phenotype1.83924591
40MP0003763_abnormal_thymus_physiology1.82379419
41MP0002723_abnormal_immune_serum1.76599932
42MP0002254_reproductive_system_inflammat1.76364712
43MP0005409_darkened_coat_color1.74640738
44MP0000685_abnormal_immune_system1.73786925
45MP0002751_abnormal_autonomic_nervous1.73605257
46MP0002420_abnormal_adaptive_immunity1.73467788
47MP0002398_abnormal_bone_marrow1.72616980
48MP0002572_abnormal_emotion/affect_behav1.72199626
49MP0001819_abnormal_immune_cell1.70910513
50MP0000955_abnormal_spinal_cord1.67891607
51MP0003191_abnormal_cellular_cholesterol1.64743650
52MP0001800_abnormal_humoral_immune1.64509226
53MP0002452_abnormal_antigen_presenting1.62793973
54MP0000858_altered_metastatic_potential1.61817257
55MP0004947_skin_inflammation1.59232408
56MP0004510_myositis1.58892851
57MP0004811_abnormal_neuron_physiology1.58632734
58MP0000678_abnormal_parathyroid_gland1.58616940
59MP0005451_abnormal_body_composition1.58464125
60MP0001533_abnormal_skeleton_physiology1.54963355
61MP0005464_abnormal_platelet_physiology1.53654497
62MP0002396_abnormal_hematopoietic_system1.52594392
63MP0004808_abnormal_hematopoietic_stem1.49437329
64MP0002405_respiratory_system_inflammati1.49307256
65MP0009840_abnormal_foam_cell1.47337750
66MP0000703_abnormal_thymus_morphology1.47288084
67MP0000716_abnormal_immune_system1.42051360
68MP0004142_abnormal_muscle_tone1.37934834
69MP0006082_CNS_inflammation1.35278050
70MP0001440_abnormal_grooming_behavior1.31454695
71MP0001348_abnormal_lacrimal_gland1.31343457
72MP0001486_abnormal_startle_reflex1.31185123
73MP0010155_abnormal_intestine_physiology1.27976141
74MP0002998_abnormal_bone_remodeling1.27261792
75MP0002429_abnormal_blood_cell1.26472278
76MP0002132_abnormal_respiratory_system1.25839587
77MP0009785_altered_susceptibility_to1.25722659
78MP0002722_abnormal_immune_system1.24654722
79MP0001501_abnormal_sleep_pattern1.22890796
80MP0004185_abnormal_adipocyte_glucose1.21931254
81MP0002882_abnormal_neuron_morphology1.21922343
82MP0001270_distended_abdomen1.19843564
83MP0003448_altered_tumor_morphology1.18766080
84MP0003453_abnormal_keratinocyte_physiol1.18684969
85MP0008260_abnormal_autophagy1.17922264
86MP0001188_hyperpigmentation1.16832123
87MP0003329_amyloid_beta_deposits1.14859079
88MP0005671_abnormal_response_to1.13956392
89MP0002557_abnormal_social/conspecific_i1.13850948
90MP0009333_abnormal_splenocyte_physiolog1.13380318
91MP0003122_maternal_imprinting1.13274998
92MP0005377_hearing/vestibular/ear_phenot1.11473930
93MP0003878_abnormal_ear_physiology1.11473930
94MP0000778_abnormal_nervous_system1.09991017
95MP0002148_abnormal_hypersensitivity_rea1.09472123
96MP0000689_abnormal_spleen_morphology1.09189814
97MP0003633_abnormal_nervous_system1.08639637
98MP0004885_abnormal_endolymph1.07906229
99MP0003091_abnormal_cell_migration1.06115198
100MP0001984_abnormal_olfaction1.03076799
101MP0002229_neurodegeneration1.02694973
102MP0003566_abnormal_cell_adhesion1.02096231
103MP0003172_abnormal_lysosome_physiology1.01899384
104MP0001845_abnormal_inflammatory_respons1.00806965
105MP0005621_abnormal_cell_physiology1.00379820
106MP0003283_abnormal_digestive_organ1.00035094
107MP0002066_abnormal_motor_capabilities/c0.99166263
108MP0008569_lethality_at_weaning0.98830397
109MP0003075_altered_response_to0.96520124
110MP0001853_heart_inflammation0.95369851
111MP0005386_behavior/neurological_phenoty0.94661125
112MP0004924_abnormal_behavior0.94661125
113MP0005666_abnormal_adipose_tissue0.94553162
114MP0003634_abnormal_glial_cell0.93837899
115MP0005390_skeleton_phenotype0.91348429
116MP0008874_decreased_physiological_sensi0.90862550
117MP0005645_abnormal_hypothalamus_physiol0.90262486
118MP0002909_abnormal_adrenal_gland0.90037159
119MP0000372_irregular_coat_pigmentation0.89296401
120MP0002752_abnormal_somatic_nervous0.88006070
121MP0004145_abnormal_muscle_electrophysio0.87810085
122MP0000534_abnormal_ureter_morphology0.87330103
123MP0004381_abnormal_hair_follicle0.85732586
124MP0000749_muscle_degeneration0.84728599
125MP0003879_abnormal_hair_cell0.82953464
126MP0009931_abnormal_skin_appearance0.82800834
127MP0005310_abnormal_salivary_gland0.82701260
128MP0003690_abnormal_glial_cell0.80827758
129MP0009764_decreased_sensitivity_to0.80822599
130MP0004742_abnormal_vestibular_system0.80760076
131MP0000750_abnormal_muscle_regeneration0.80752385
132MP0003631_nervous_system_phenotype0.79054623
133MP0010386_abnormal_urinary_bladder0.78481824
134MP0000470_abnormal_stomach_morphology0.78376127
135MP0005174_abnormal_tail_pigmentation0.78344444
136MP0005023_abnormal_wound_healing0.77378233
137MP0003828_pulmonary_edema0.77145717
138MP0001299_abnormal_eye_distance/0.76975137
139MP0003111_abnormal_nucleus_morphology0.76678171
140MP0008469_abnormal_protein_level0.75362520
141MP0003045_fibrosis0.74229333
142MP0001664_abnormal_digestion0.72952577
143MP0003656_abnormal_erythrocyte_physiolo0.72875161
144MP0001963_abnormal_hearing_physiology0.72406500
145MP0004085_abnormal_heartbeat0.72019965
146MP0005171_absent_coat_pigmentation0.71850854
147MP0001905_abnormal_dopamine_level0.69319185
148MP0005375_adipose_tissue_phenotype0.69237606
149MP0001851_eye_inflammation0.69222355
150MP0000313_abnormal_cell_death0.68990039
151MP0005257_abnormal_intraocular_pressure0.68186676
152MP0001849_ear_inflammation0.66828807
153MP0002060_abnormal_skin_morphology0.65186908
154MP0005384_cellular_phenotype0.64568341
155MP0001958_emphysema0.64343097
156MP0000569_abnormal_digit_pigmentation0.64319003
157MP0005083_abnormal_biliary_tract0.62399137
158MP0002163_abnormal_gland_morphology0.62118535
159MP0008961_abnormal_basal_metabolism0.59695404
160MP0009780_abnormal_chondrocyte_physiolo0.59508284
161MP0002638_abnormal_pupillary_reflex0.59123896
162MP0001502_abnormal_circadian_rhythm0.58589706
163MP0002837_dystrophic_cardiac_calcinosis0.56717445
164MP0000751_myopathy0.54184951
165MP0002152_abnormal_brain_morphology0.53700353
166MP0005379_endocrine/exocrine_gland_phen0.53130540
167MP0000747_muscle_weakness0.51304989
168MP0000604_amyloidosis0.51067320
169MP0004147_increased_porphyrin_level0.50636755
170MP0001485_abnormal_pinna_reflex0.50088902
171MP0002069_abnormal_eating/drinking_beha0.47618951
172MP0004883_abnormal_blood_vessel0.46914795
173MP0000538_abnormal_urinary_bladder0.45909655
174MP0001943_abnormal_respiration0.45649469
175MP0000015_abnormal_ear_pigmentation0.44328199
176MP0000920_abnormal_myelination0.43005189
177MP0006292_abnormal_olfactory_placode0.42431855
178MP0002822_catalepsy0.42382652
179MP0005646_abnormal_pituitary_gland0.42041277
180MP0008872_abnormal_physiological_respon0.41650299
181MP0002972_abnormal_cardiac_muscle0.41525739
182MP0002928_abnormal_bile_duct0.40324770
183MP0003279_aneurysm0.38344330

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)7.44646091
2Myokymia (HP:0002411)6.28637178
3Action tremor (HP:0002345)4.90452776
4Febrile seizures (HP:0002373)4.79911919
5Focal motor seizures (HP:0011153)4.38940305
6Atonic seizures (HP:0010819)4.38470495
7Segmental peripheral demyelination/remyelination (HP:0003481)4.36226072
8Focal seizures (HP:0007359)4.17600555
9Insidious onset (HP:0003587)4.16122757
10Termporal pattern (HP:0011008)4.16122757
11Dysautonomia (HP:0002459)4.12549129
12Pheochromocytoma (HP:0002666)4.09225598
13Abnormality of pain sensation (HP:0010832)3.99773865
14Impaired pain sensation (HP:0007328)3.99773865
15Neuroendocrine neoplasm (HP:0100634)3.73994584
16Steppage gait (HP:0003376)3.53012150
17Hypothermia (HP:0002045)3.52159746
18Progressive cerebellar ataxia (HP:0002073)3.51615640
19Epileptic encephalopathy (HP:0200134)3.48624582
20Elevated erythrocyte sedimentation rate (HP:0003565)3.45781284
21Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.39822119
22Supranuclear gaze palsy (HP:0000605)3.39442431
23Thoracolumbar scoliosis (HP:0002944)3.32538270
24Visual hallucinations (HP:0002367)3.31817367
25Distal arthrogryposis (HP:0005684)3.20166033
26Hammertoe (HP:0001765)3.17797589
27Thin bony cortex (HP:0002753)3.16406889
28Ankle clonus (HP:0011448)3.09121225
29Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.07499654
30Obstructive sleep apnea (HP:0002870)3.06880956
31Failure to thrive in infancy (HP:0001531)3.05284141
32Eczematoid dermatitis (HP:0000976)3.03297246
33Chronic mucocutaneous candidiasis (HP:0002728)3.02388956
34Recurrent cutaneous fungal infections (HP:0011370)3.02388956
35Generalized tonic-clonic seizures (HP:0002069)2.99967613
36Truncal ataxia (HP:0002078)2.94540305
37Abnormality of macrophages (HP:0004311)2.93152755
38Foot dorsiflexor weakness (HP:0009027)2.92354961
39Absence seizures (HP:0002121)2.91914485
40Abnormality of the fingertips (HP:0001211)2.91715071
41Dialeptic seizures (HP:0011146)2.83402411
42Submucous cleft hard palate (HP:0000176)2.81834013
43Myositis (HP:0100614)2.80954960
44Abnormal autonomic nervous system physiology (HP:0012332)2.73762296
45Broad face (HP:0000283)2.73246140
46Recurrent abscess formation (HP:0002722)2.72204868
47Recurrent fungal infections (HP:0002841)2.67060466
48Recurrent bacterial skin infections (HP:0005406)2.65911639
49Long palpebral fissure (HP:0000637)2.64487902
50Bradycardia (HP:0001662)2.62626896
51Myotonia (HP:0002486)2.62510047
52Abnormality of the foot musculature (HP:0001436)2.61624618
53Peripheral hypomyelination (HP:0007182)2.60924670
54Hypercortisolism (HP:0001578)2.60678454
55Peritonitis (HP:0002586)2.58396233
56Cheilitis (HP:0100825)2.54926626
57Postural tremor (HP:0002174)2.54246101
58Diplopia (HP:0000651)2.54038696
59Abnormality of binocular vision (HP:0011514)2.54038696
60Increased IgE level (HP:0003212)2.51574871
61Abnormality of the vocal cords (HP:0008777)2.49975982
62Distal sensory impairment (HP:0002936)2.47451472
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45692477
64Abnormality of calcium-phosphate metabolism (HP:0100530)2.44859169
65Onion bulb formation (HP:0003383)2.44145904
66Orchitis (HP:0100796)2.42579455
67Recurrent skin infections (HP:0001581)2.42185687
68Chin dimple (HP:0010751)2.40298544
69Hemorrhage of the eye (HP:0011885)2.39894951
70Hypoplasia of the brainstem (HP:0002365)2.38703498
71Aplasia/Hypoplasia of the brainstem (HP:0007362)2.38703498
72Disproportionate tall stature (HP:0001519)2.36786292
73Abnormality of glycolipid metabolism (HP:0010969)2.35639479
74Abnormality of liposaccharide metabolism (HP:0010968)2.35639479
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.35639479
76Urinary bladder sphincter dysfunction (HP:0002839)2.35486465
77Hypoventilation (HP:0002791)2.35090110
78Hemiparesis (HP:0001269)2.34232351
79Vertebral arch anomaly (HP:0008438)2.34157125
80Impaired proprioception (HP:0010831)2.32674571
81Obstructive lung disease (HP:0006536)2.30681752
82Chronic obstructive pulmonary disease (HP:0006510)2.30681752
83Neoplasm of the peripheral nervous system (HP:0100007)2.28728853
84Decreased motor nerve conduction velocity (HP:0003431)2.28477706
85Hyperacusis (HP:0010780)2.27356778
86Mask-like facies (HP:0000298)2.27201098
87Mutism (HP:0002300)2.21927332
88Limb dystonia (HP:0002451)2.21215527
89Urinary urgency (HP:0000012)2.20767793
90Metaphyseal cupping (HP:0003021)2.19803104
91Cellulitis (HP:0100658)2.16874060
92Turricephaly (HP:0000262)2.16514698
93Slow saccadic eye movements (HP:0000514)2.14844566
94Potter facies (HP:0002009)2.14183644
95Facial shape deformation (HP:0011334)2.14183644
96Abnormality of the lower motor neuron (HP:0002366)2.14000045
97Neurofibrillary tangles (HP:0002185)2.13828274
98Retrobulbar optic neuritis (HP:0100654)2.13624284
99Optic neuritis (HP:0100653)2.13624284
100Increased corneal curvature (HP:0100692)2.10763790
101Keratoconus (HP:0000563)2.10763790
102Testicular atrophy (HP:0000029)2.10420211
103Genu recurvatum (HP:0002816)2.09699723
104Long eyelashes (HP:0000527)2.08736665
105Gaze-evoked nystagmus (HP:0000640)2.08714707
106Gastrointestinal infarctions (HP:0005244)2.06788656
107Meningitis (HP:0001287)2.06149901
108Lower limb muscle weakness (HP:0007340)2.04683588
109Thyroid carcinoma (HP:0002890)2.03568175
110Spastic gait (HP:0002064)2.03385770
111Emphysema (HP:0002097)2.02558349
112Agitation (HP:0000713)2.02299786
113Depression (HP:0000716)2.01519407
114Atelectasis (HP:0100750)2.00396307
115Ulnar bowing (HP:0003031)1.98041294
116Prolonged bleeding time (HP:0003010)1.97153088
117Spondylolisthesis (HP:0003302)1.96807845
118Abnormality of the corticospinal tract (HP:0002492)1.96438684
119Truncus arteriosus (HP:0001660)1.96243164
120Mediastinal lymphadenopathy (HP:0100721)1.96025351
121Hypokinesia (HP:0002375)1.95632302
122Abnormal hair whorl (HP:0010721)1.95499859
123Abnormality of the thoracic spine (HP:0100711)1.95115209
124Episodic fever (HP:0001954)1.93390089
125Bowel incontinence (HP:0002607)1.92916927
126Anteriorly placed anus (HP:0001545)1.91843368
127Cutaneous finger syndactyly (HP:0010554)1.88450344
128Abnormality of the aortic arch (HP:0012303)1.88239980
129Progressive external ophthalmoplegia (HP:0000590)1.86806670
130Amblyopia (HP:0000646)1.86645684
131Pointed chin (HP:0000307)1.86410860
132Broad metatarsal (HP:0001783)1.84588929
133Spontaneous hematomas (HP:0007420)1.84518613
134Hemiplegia (HP:0002301)1.83333624
135Insomnia (HP:0100785)1.83311659
136Abnormal delayed hypersensitivity skin test (HP:0002963)1.82952122
137Abnormality of the peritoneum (HP:0002585)1.82602553
138Rapidly progressive (HP:0003678)1.82473018
139Abnormal large intestine physiology (HP:0012700)1.81893473
140Annular pancreas (HP:0001734)1.81141765
141Vasculitis (HP:0002633)1.80780971
142Thoracic kyphosis (HP:0002942)1.80204360
143Thrombocytosis (HP:0001894)1.79989794
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79256761
145Abnormality of polysaccharide metabolism (HP:0011012)1.79256761
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79256761
147Orthostatic hypotension (HP:0001278)1.79107552
148Stomatitis (HP:0010280)1.78771239
149Epistaxis (HP:0000421)1.78671787
150Decreased muscle mass (HP:0003199)1.77789064
151Shallow orbits (HP:0000586)1.77526216
152Spinal canal stenosis (HP:0003416)1.76893849
153Specific learning disability (HP:0001328)1.76514956
154Impaired vibration sensation in the lower limbs (HP:0002166)1.76353849
155Supernumerary nipples (HP:0002558)1.75894209
156Exotropia (HP:0000577)1.75317758
157Hypertensive crisis (HP:0100735)1.74253531
158Menstrual irregularities (HP:0000858)1.74232700
159Paraplegia (HP:0010550)1.74095756
160Overlapping toe (HP:0001845)1.72899999
161Neuronal loss in central nervous system (HP:0002529)1.72863042
162Ventricular fibrillation (HP:0001663)1.72833892
163Spinal cord lesions (HP:0100561)1.72811440
164Syringomyelia (HP:0003396)1.72811440
165Arterial thrombosis (HP:0004420)1.70790169
166Anosmia (HP:0000458)1.70524895
167Cervical subluxation (HP:0003308)1.70501949
168Abnormality of the columella (HP:0009929)1.67991229
169Abnormal eating behavior (HP:0100738)1.67962703
170Recurrent gram-negative bacterial infections (HP:0005420)1.67933752
171Aqueductal stenosis (HP:0002410)1.67873291
172Urticaria (HP:0001025)1.67765009
173Gingivitis (HP:0000230)1.67553152
174Intestinal fistula (HP:0100819)1.66460943
175Premature skin wrinkling (HP:0100678)1.65905425
176Increased CSF protein (HP:0002922)1.65645775
177Supernumerary ribs (HP:0005815)1.65249559
178Polygenic inheritance (HP:0010982)1.65092916
179Basal cell carcinoma (HP:0002671)1.64914287
180Areflexia of lower limbs (HP:0002522)1.64888497
181Dysostosis multiplex (HP:0000943)1.64821873
182Chest pain (HP:0100749)1.63964160
183Rib fusion (HP:0000902)1.63696708
184Hemoptysis (HP:0002105)1.62867340
185Dilatation of the ascending aorta (HP:0005111)1.62618117
186Urinary glycosaminoglycan excretion (HP:0003541)1.61797203
187Mucopolysacchariduria (HP:0008155)1.61797203
188Mitral regurgitation (HP:0001653)1.59392010
189Polycythemia (HP:0001901)1.57163093
190Gastrointestinal inflammation (HP:0004386)1.57066226
191Narrow palate (HP:0000189)1.57046411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.41682466
2NTRK34.33667743
3NTRK13.73236250
4CDK123.72468504
5CASK3.30697627
6SMG13.27013786
7KSR23.22832381
8TRIB33.19252189
9GRK53.18146240
10LMTK23.12086528
11ERN13.08150695
12MAP4K13.06050999
13MINK12.98975799
14MAP3K22.40105588
15RIPK42.33522718
16MATK2.29700077
17LATS22.24751150
18MAP2K32.23790301
19SIK12.21860112
20RET2.01337353
21LIMK12.00478918
22IRAK41.95731457
23MAP3K121.93846656
24MAPKAPK31.81652791
25SIK31.80304120
26ARAF1.73861947
27MAP3K111.72259426
28IRAK31.71649063
29MAP2K71.68486682
30PHKG21.64338824
31PHKG11.64338824
32ICK1.64081935
33MAPK131.63455631
34PRKD31.60670484
35TYK21.57420134
36EPHB11.57187356
37ZAP701.57105344
38TBK11.51674329
39MAP3K41.51606181
40MAP3K141.49862095
41FGFR41.47440722
42MAP2K41.39882533
43TAOK21.37676428
44TESK21.36777791
45JAK31.34106208
46PAK61.30002128
47BRD41.29818605
48BLK1.23636967
49SGK21.22207049
50TAOK11.19269773
51MAP3K71.17779533
52SGK2231.15450660
53SGK4941.15450660
54MARK31.13369348
55CSK1.12945306
56SIK21.11705151
57RIPK11.11702946
58FGR1.11120760
59MARK11.10071674
60DAPK21.09820409
61CDK51.09750041
62RPS6KA21.04685292
63TYRO31.00886856
64BTK1.00491206
65MAP2K10.99696824
66GRK60.98158385
67WNK10.97472805
68MAP3K10.95944275
69PKN20.95536090
70MTOR0.94848314
71IKBKE0.94844333
72CAMKK20.92280475
73TNK20.89405128
74JAK10.88934569
75IRAK20.88841024
76HCK0.88308171
77BMX0.87042426
78SGK30.86710092
79DAPK10.86132571
80FER0.85402979
81PTK60.84818234
82PTK2B0.79154586
83MAP3K60.78335609
84CAMKK10.78183906
85CDK140.78112077
86STK110.77160922
87PRKD20.76125766
88EEF2K0.75669551
89PDGFRA0.74354910
90MAP3K30.74028337
91UHMK10.73324625
92ADRBK20.73319697
93PLK20.72800520
94CDK90.72511406
95CDC42BPA0.70709769
96PRKCG0.70365675
97GRK70.70195990
98EPHA30.69674039
99PRKG20.68450288
100MAP3K130.65504152
101JAK20.65150228
102ADRBK10.63951256
103HIPK20.62445098
104STK380.61730868
105CDK40.61152539
106EPHA40.60621926
107MAP3K80.60531763
108PDK10.59098213
109MAPK70.58567322
110FES0.58291234
111RPS6KL10.57576484
112RPS6KC10.57576484
113PRKCH0.57375788
114CSNK1G20.56812346
115LRRK20.56805540
116SYK0.56606739
117PRKCE0.56555544
118STK240.56234284
119PINK10.55539867
120FLT30.55220490
121MAPKAPK50.54835316
122MAP3K100.54316143
123CAMK2A0.54258992
124MAPK120.54244683
125DDR20.54141347
126IRAK10.54096775
127CAMK10.53013164
128PDPK10.51790021
129AKT30.51358033
130MARK20.51214484
131PASK0.51075164
132PTK20.50058012
133DYRK1B0.49672002
134PRPF4B0.48911747
135CDK180.48316492
136PDGFRB0.47845307
137CSF1R0.47034811
138CDK70.44943060
139CAMK2D0.44013918
140CLK10.43339429
141CDK150.43050053
142YES10.42240188
143FGFR30.42041837
144LCK0.42039169
145NTRK20.41697983
146MAPK150.41459370
147CAMK40.41398503
148ITK0.41176663
149RPS6KA60.39557105
150BRAF0.39116191
151ALK0.39011553
152SCYL20.38662910
153MAP2K60.38573616
154TNIK0.38455880
155MUSK0.38388416
156PRKCZ0.38240184
157PRKACA0.37554453
158MELK0.36949019
159CDK11A0.35870775
160LYN0.35248065
161MAPK100.35024252
162IKBKB0.34111857
163CSNK1A1L0.31787676
164MAP2K20.30592270
165KSR10.27521238
166RAF10.27514094
167PAK30.26807160
168PRKACG0.26659688
169CSNK1G30.26433161

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.28178733
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.05112213
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.53991406
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.39435449
5Taste transduction_Homo sapiens_hsa047422.36334243
6Nicotine addiction_Homo sapiens_hsa050332.31530060
7Other glycan degradation_Homo sapiens_hsa005112.27814419
8Olfactory transduction_Homo sapiens_hsa047402.23030026
9Acute myeloid leukemia_Homo sapiens_hsa052212.20336233
10Insulin secretion_Homo sapiens_hsa049112.17960279
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.17956662
12Osteoclast differentiation_Homo sapiens_hsa043802.12606589
13Long-term potentiation_Homo sapiens_hsa047202.01552198
14Circadian entrainment_Homo sapiens_hsa047131.96561921
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94095375
16Chronic myeloid leukemia_Homo sapiens_hsa052201.91222696
17Glutamatergic synapse_Homo sapiens_hsa047241.88905612
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88265220
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86581828
20B cell receptor signaling pathway_Homo sapiens_hsa046621.82372375
21Salivary secretion_Homo sapiens_hsa049701.82099842
22Dopaminergic synapse_Homo sapiens_hsa047281.81785673
23Leishmaniasis_Homo sapiens_hsa051401.78934052
24Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.78722747
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72426354
26GABAergic synapse_Homo sapiens_hsa047271.68438594
27Cholinergic synapse_Homo sapiens_hsa047251.65951411
28Morphine addiction_Homo sapiens_hsa050321.64428849
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62865756
30Serotonergic synapse_Homo sapiens_hsa047261.62056404
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.60670100
32Dorso-ventral axis formation_Homo sapiens_hsa043201.50214271
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48766857
34Pancreatic cancer_Homo sapiens_hsa052121.47792739
35Amphetamine addiction_Homo sapiens_hsa050311.45796529
36Malaria_Homo sapiens_hsa051441.45701027
37Notch signaling pathway_Homo sapiens_hsa043301.45204186
38Long-term depression_Homo sapiens_hsa047301.43618746
39Measles_Homo sapiens_hsa051621.41564526
40Influenza A_Homo sapiens_hsa051641.41276325
41Thyroid cancer_Homo sapiens_hsa052161.40281510
42Tuberculosis_Homo sapiens_hsa051521.37316575
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36451651
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.35426168
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30064270
46GnRH signaling pathway_Homo sapiens_hsa049121.29649380
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.29405353
48TNF signaling pathway_Homo sapiens_hsa046681.29082186
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28083039
50Hepatitis B_Homo sapiens_hsa051611.27779878
51Gap junction_Homo sapiens_hsa045401.26407586
52Renin secretion_Homo sapiens_hsa049241.26142852
53Collecting duct acid secretion_Homo sapiens_hsa049661.23701022
54Shigellosis_Homo sapiens_hsa051311.23234071
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.23181019
56Gastric acid secretion_Homo sapiens_hsa049711.22789044
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22167627
58Calcium signaling pathway_Homo sapiens_hsa040201.22111208
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19988438
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19884590
61Renal cell carcinoma_Homo sapiens_hsa052111.19181530
62Cardiac muscle contraction_Homo sapiens_hsa042601.18939795
63T cell receptor signaling pathway_Homo sapiens_hsa046601.18751530
64Chemokine signaling pathway_Homo sapiens_hsa040621.18331665
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17376508
66Oxytocin signaling pathway_Homo sapiens_hsa049211.16732187
67Hepatitis C_Homo sapiens_hsa051601.14944232
68Glioma_Homo sapiens_hsa052141.13369443
69Toxoplasmosis_Homo sapiens_hsa051451.12710783
70Regulation of autophagy_Homo sapiens_hsa041401.11174895
71Herpes simplex infection_Homo sapiens_hsa051681.09666070
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07443821
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01744573
74Amoebiasis_Homo sapiens_hsa051461.01668325
75Bladder cancer_Homo sapiens_hsa052191.01641866
76Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01638922
77Phospholipase D signaling pathway_Homo sapiens_hsa040721.01501522
78Melanogenesis_Homo sapiens_hsa049161.00287438
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99533536
80ErbB signaling pathway_Homo sapiens_hsa040120.99454649
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.97055155
82Type II diabetes mellitus_Homo sapiens_hsa049300.96729953
83Estrogen signaling pathway_Homo sapiens_hsa049150.96473766
84Melanoma_Homo sapiens_hsa052180.96310622
85Prostate cancer_Homo sapiens_hsa052150.94935591
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94272593
87Legionellosis_Homo sapiens_hsa051340.94061261
88Choline metabolism in cancer_Homo sapiens_hsa052310.93673346
89Cocaine addiction_Homo sapiens_hsa050300.92683381
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.89991132
91Apoptosis_Homo sapiens_hsa042100.89653414
92cAMP signaling pathway_Homo sapiens_hsa040240.89470731
93Axon guidance_Homo sapiens_hsa043600.88239491
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.88110309
95Vibrio cholerae infection_Homo sapiens_hsa051100.85576291
96Oocyte meiosis_Homo sapiens_hsa041140.84139603
97Mineral absorption_Homo sapiens_hsa049780.83260254
98Endometrial cancer_Homo sapiens_hsa052130.82979935
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82123437
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81937891
101VEGF signaling pathway_Homo sapiens_hsa043700.81794005
102Epstein-Barr virus infection_Homo sapiens_hsa051690.80992874
103HTLV-I infection_Homo sapiens_hsa051660.79685281
104MAPK signaling pathway_Homo sapiens_hsa040100.79215940
105Rap1 signaling pathway_Homo sapiens_hsa040150.78164245
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77868598
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77303674
108Pancreatic secretion_Homo sapiens_hsa049720.75201657
109Thyroid hormone synthesis_Homo sapiens_hsa049180.73937917
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73719689
111Insulin signaling pathway_Homo sapiens_hsa049100.73022327
112Pertussis_Homo sapiens_hsa051330.72734712
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.72496393
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.69889138
115Ras signaling pathway_Homo sapiens_hsa040140.69158071
116mRNA surveillance pathway_Homo sapiens_hsa030150.68623243
117Prolactin signaling pathway_Homo sapiens_hsa049170.68403076
118mTOR signaling pathway_Homo sapiens_hsa041500.68157648
119FoxO signaling pathway_Homo sapiens_hsa040680.67096633
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66160608
121Endocytosis_Homo sapiens_hsa041440.66077999
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65777892
123Salmonella infection_Homo sapiens_hsa051320.65615354
124Hedgehog signaling pathway_Homo sapiens_hsa043400.65502736
125MicroRNAs in cancer_Homo sapiens_hsa052060.64109663
126Primary immunodeficiency_Homo sapiens_hsa053400.63828849
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62715007
128Staphylococcus aureus infection_Homo sapiens_hsa051500.62668097
129Phototransduction_Homo sapiens_hsa047440.62216931
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61931154
131Prion diseases_Homo sapiens_hsa050200.58438041
132Hematopoietic cell lineage_Homo sapiens_hsa046400.57903296
133Insulin resistance_Homo sapiens_hsa049310.57761627
134HIF-1 signaling pathway_Homo sapiens_hsa040660.57603211
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.57548737
136Phagosome_Homo sapiens_hsa041450.55878011
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54639371
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54224436
139Viral carcinogenesis_Homo sapiens_hsa052030.53967593
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.53918703
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52814804
142Proteoglycans in cancer_Homo sapiens_hsa052050.51970919
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47709957
144Wnt signaling pathway_Homo sapiens_hsa043100.46248068
145Glucagon signaling pathway_Homo sapiens_hsa049220.45942273
146Inositol phosphate metabolism_Homo sapiens_hsa005620.41858061
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40387595
148Rheumatoid arthritis_Homo sapiens_hsa053230.39990280
149Non-small cell lung cancer_Homo sapiens_hsa052230.39093010
150Alzheimers disease_Homo sapiens_hsa050100.38467076
151Renin-angiotensin system_Homo sapiens_hsa046140.38223434
152Platelet activation_Homo sapiens_hsa046110.37291530
153Dilated cardiomyopathy_Homo sapiens_hsa054140.36082341
154Lysosome_Homo sapiens_hsa041420.34269330
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34127684
156Colorectal cancer_Homo sapiens_hsa052100.32880296
157African trypanosomiasis_Homo sapiens_hsa051430.32381806
158Parkinsons disease_Homo sapiens_hsa050120.32185101

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