KCND2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.65952774
2ionotropic glutamate receptor signaling pathway (GO:0035235)5.55627355
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43819072
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42700455
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.41577583
6glutamate receptor signaling pathway (GO:0007215)5.18291004
7locomotory exploration behavior (GO:0035641)5.18108955
8righting reflex (GO:0060013)5.11932946
9regulation of glutamate receptor signaling pathway (GO:1900449)4.96032130
10neuron cell-cell adhesion (GO:0007158)4.87223866
11neuronal action potential propagation (GO:0019227)4.85764370
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85139785
13protein localization to synapse (GO:0035418)4.83343127
14synaptic vesicle exocytosis (GO:0016079)4.82304685
15synaptic transmission, glutamatergic (GO:0035249)4.65316861
16neuron-neuron synaptic transmission (GO:0007270)4.54162350
17gamma-aminobutyric acid signaling pathway (GO:0007214)4.50935808
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.45698642
19exploration behavior (GO:0035640)4.40284945
20mechanosensory behavior (GO:0007638)4.39771372
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.39053774
22regulation of synaptic vesicle exocytosis (GO:2000300)4.33016732
23L-amino acid import (GO:0043092)4.32743842
24synaptic vesicle maturation (GO:0016188)4.29227047
25glutamate secretion (GO:0014047)4.26048912
26neurotransmitter-gated ion channel clustering (GO:0072578)4.13140421
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.11899932
28neuron recognition (GO:0008038)4.10276644
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.08150082
30long-term memory (GO:0007616)4.07661587
31positive regulation of synapse maturation (GO:0090129)4.04995690
32regulation of neuronal synaptic plasticity (GO:0048168)4.04272812
33neurotransmitter secretion (GO:0007269)4.02495222
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.99029706
35gamma-aminobutyric acid transport (GO:0015812)3.98781065
36transmission of nerve impulse (GO:0019226)3.97661578
37response to auditory stimulus (GO:0010996)3.94391610
38regulation of postsynaptic membrane potential (GO:0060078)3.91767555
39amino acid import (GO:0043090)3.90558094
40potassium ion import (GO:0010107)3.90227858
41regulation of synaptic vesicle transport (GO:1902803)3.90215415
42cellular potassium ion homeostasis (GO:0030007)3.89195349
43neurotransmitter uptake (GO:0001504)3.86874019
44dendritic spine morphogenesis (GO:0060997)3.85775194
45regulation of dendritic spine morphogenesis (GO:0061001)3.83625498
46regulation of synapse structural plasticity (GO:0051823)3.81669161
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.80257607
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.80040550
49potassium ion homeostasis (GO:0055075)3.79416569
50long-term synaptic potentiation (GO:0060291)3.77028036
51response to histamine (GO:0034776)3.76671385
52cerebellar granule cell differentiation (GO:0021707)3.72502079
53layer formation in cerebral cortex (GO:0021819)3.71812667
54axonal fasciculation (GO:0007413)3.71759779
55presynaptic membrane assembly (GO:0097105)3.69981736
56positive regulation of membrane potential (GO:0045838)3.67350472
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.61310467
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60896839
59regulation of synaptic plasticity (GO:0048167)3.59392595
60central nervous system myelination (GO:0022010)3.58585006
61axon ensheathment in central nervous system (GO:0032291)3.58585006
62adult walking behavior (GO:0007628)3.57723148
63cellular sodium ion homeostasis (GO:0006883)3.55015689
64postsynaptic membrane organization (GO:0001941)3.54046099
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.53788713
66behavioral fear response (GO:0001662)3.53323881
67behavioral defense response (GO:0002209)3.53323881
68presynaptic membrane organization (GO:0097090)3.50335848
69neuronal ion channel clustering (GO:0045161)3.45259565
70fear response (GO:0042596)3.40887121
71long term synaptic depression (GO:0060292)3.39240677
72synaptic vesicle endocytosis (GO:0048488)3.38857039
73neurotransmitter transport (GO:0006836)3.37071831
74regulation of vesicle fusion (GO:0031338)3.35568305
75cerebellar Purkinje cell differentiation (GO:0021702)3.34929471
76membrane depolarization (GO:0051899)3.32351563
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.31721438
78neuromuscular process (GO:0050905)3.28722812
79regulation of dendritic spine development (GO:0060998)3.27517390
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25712301
81regulation of female receptivity (GO:0045924)3.25513435
82learning (GO:0007612)3.25374976
83synapse assembly (GO:0007416)3.25338323
84behavioral response to cocaine (GO:0048148)3.21627501
85positive regulation of dendritic spine development (GO:0060999)3.21140008
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21133327
87sodium ion export (GO:0071436)3.20520105
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20106148
89regulation of neurotransmitter transport (GO:0051588)3.19557733
90regulation of synapse maturation (GO:0090128)3.19486623
91regulation of axon regeneration (GO:0048679)3.19395088
92regulation of neuron projection regeneration (GO:0070570)3.19395088
93positive regulation of neurotransmitter secretion (GO:0001956)3.18342751
94membrane assembly (GO:0071709)3.18275253
95regulation of glutamate secretion (GO:0014048)3.17228127
96proline transport (GO:0015824)3.16209767
97neuromuscular process controlling balance (GO:0050885)3.15405703
98membrane depolarization during action potential (GO:0086010)3.15013062
99regulation of neurotransmitter levels (GO:0001505)3.14647409
100dendritic spine organization (GO:0097061)3.10872723
101auditory behavior (GO:0031223)3.10816429
102female mating behavior (GO:0060180)3.09385068
103regulation of neurotransmitter secretion (GO:0046928)3.08801192
104membrane hyperpolarization (GO:0060081)3.08151589
105positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07475990
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07296136
107positive regulation of synapse assembly (GO:0051965)3.07162299
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05645789
109innervation (GO:0060384)3.05419915
110neuromuscular process controlling posture (GO:0050884)3.04401356
111activation of protein kinase A activity (GO:0034199)3.04236914
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03358347
113regulation of voltage-gated calcium channel activity (GO:1901385)3.02738145
114cell communication by electrical coupling (GO:0010644)3.00108607
115cerebellar Purkinje cell layer development (GO:0021680)2.99899371
116startle response (GO:0001964)2.99154460
117cell communication involved in cardiac conduction (GO:0086065)2.98903248
118acidic amino acid transport (GO:0015800)2.98620709
119prepulse inhibition (GO:0060134)2.98025393
120* synaptic transmission (GO:0007268)2.97733603
121detection of calcium ion (GO:0005513)2.97304755
122positive regulation of neurotransmitter transport (GO:0051590)2.96723190
123serotonin metabolic process (GO:0042428)2.96711862
124synapse organization (GO:0050808)2.95741783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.37804577
2* GBX2_23144817_ChIP-Seq_PC3_Human3.81507211
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18260153
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17358494
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14506304
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71601665
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71601665
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71010724
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.64968490
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61815576
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56621411
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53287034
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.52271001
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49176634
15* RARB_27405468_Chip-Seq_BRAIN_Mouse2.42086475
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41143119
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40428095
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.33974079
19DROSHA_22980978_ChIP-Seq_HELA_Human2.30092780
20TAF15_26573619_Chip-Seq_HEK293_Human2.16619617
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.15694392
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15008999
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13568108
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.09764253
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08482258
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02426655
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99831930
28AR_21572438_ChIP-Seq_LNCaP_Human1.93406875
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90123621
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82746245
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.80402341
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78195660
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76756584
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76110655
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73039738
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72802289
37ZNF274_21170338_ChIP-Seq_K562_Hela1.68225017
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65969064
39* P300_19829295_ChIP-Seq_ESCs_Human1.63023036
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56478752
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55701784
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45418645
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.44986355
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.44921685
45* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44079767
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.43803981
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41415018
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40357829
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39538129
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39121026
51FUS_26573619_Chip-Seq_HEK293_Human1.37526618
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36752541
53* AR_25329375_ChIP-Seq_VCAP_Human1.36302202
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36183132
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.36155968
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35471375
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.33341618
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33272600
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32464750
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29485777
61* STAT3_23295773_ChIP-Seq_U87_Human1.26863977
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.25645020
63TP53_16413492_ChIP-PET_HCT116_Human1.25100567
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23669806
65IGF1R_20145208_ChIP-Seq_DFB_Human1.20196413
66AR_19668381_ChIP-Seq_PC3_Human1.18649361
67SOX9_26525672_Chip-Seq_HEART_Mouse1.18050331
68VDR_22108803_ChIP-Seq_LS180_Human1.17466044
69* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16905049
70TCF4_23295773_ChIP-Seq_U87_Human1.16339485
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14349596
72RNF2_27304074_Chip-Seq_NSC_Mouse1.12602957
73RUNX2_22187159_ChIP-Seq_PCA_Human1.10100909
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09947331
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.09582533
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.09575445
77KDM2B_26808549_Chip-Seq_REH_Human1.08584142
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08207494
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07837500
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06759600
81TP53_18474530_ChIP-ChIP_U2OS_Human1.06048705
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05925237
83* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05866370
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05524213
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05339924
86ER_23166858_ChIP-Seq_MCF-7_Human1.05080494
87BCAT_22108803_ChIP-Seq_LS180_Human1.04955394
88EWS_26573619_Chip-Seq_HEK293_Human1.04084579
89* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03791635
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03682522
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02517509
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02436670
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01702683
94* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00468276
95AHR_22903824_ChIP-Seq_MCF-7_Human0.99707196
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99018418
97JUN_21703547_ChIP-Seq_K562_Human0.98799938
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98524563
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98524563
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98138364
101TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98127346
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97444910
103TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96663327
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.96658991
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96111652
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96050032
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95095468
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94346036
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93243950
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.92149465
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91781336
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91158827
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91058817
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.89565571
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.88898610
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88174053
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87715463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.13987520
2MP0003880_abnormal_central_pattern5.49548902
3* MP0003635_abnormal_synaptic_transmissio4.20945779
4MP0009745_abnormal_behavioral_response3.63081039
5MP0004270_analgesia3.53910542
6MP0002063_abnormal_learning/memory/cond3.42288479
7MP0002064_seizures3.24077773
8MP0009046_muscle_twitch3.23896356
9MP0002572_abnormal_emotion/affect_behav2.95733084
10MP0002272_abnormal_nervous_system2.81235778
11* MP0001968_abnormal_touch/_nociception2.72898967
12MP0002822_catalepsy2.58712077
13MP0001501_abnormal_sleep_pattern2.57899131
14MP0001486_abnormal_startle_reflex2.56117675
15MP0005423_abnormal_somatic_nervous2.51745674
16MP0001440_abnormal_grooming_behavior2.49098592
17* MP0002734_abnormal_mechanical_nocicepti2.28790402
18MP0002735_abnormal_chemical_nociception2.26019693
19* MP0002067_abnormal_sensory_capabilities2.08349214
20* MP0002736_abnormal_nociception_after2.02716987
21MP0002184_abnormal_innervation1.94619941
22MP0003329_amyloid_beta_deposits1.92267264
23MP0008569_lethality_at_weaning1.91372536
24MP0000778_abnormal_nervous_system1.86082618
25MP0006276_abnormal_autonomic_nervous1.85849748
26MP0005386_behavior/neurological_phenoty1.83303794
27MP0004924_abnormal_behavior1.83303794
28MP0001529_abnormal_vocalization1.80512776
29* MP0002733_abnormal_thermal_nociception1.80237870
30* MP0001970_abnormal_pain_threshold1.78150661
31MP0002557_abnormal_social/conspecific_i1.74346825
32MP0009780_abnormal_chondrocyte_physiolo1.68802680
33MP0002909_abnormal_adrenal_gland1.63002824
34MP0001188_hyperpigmentation1.61838469
35MP0002837_dystrophic_cardiac_calcinosis1.52587862
36MP0005646_abnormal_pituitary_gland1.50881334
37MP0004145_abnormal_muscle_electrophysio1.50400753
38MP0004811_abnormal_neuron_physiology1.49495284
39MP0001984_abnormal_olfaction1.49140705
40MP0003879_abnormal_hair_cell1.47241712
41MP0004858_abnormal_nervous_system1.45528056
42MP0005645_abnormal_hypothalamus_physiol1.44284435
43MP0002066_abnormal_motor_capabilities/c1.43422728
44MP0000955_abnormal_spinal_cord1.43344125
45MP0004885_abnormal_endolymph1.34694369
46MP0003787_abnormal_imprinting1.34131019
47MP0004142_abnormal_muscle_tone1.33899658
48MP0001502_abnormal_circadian_rhythm1.32870371
49* MP0002882_abnormal_neuron_morphology1.32239832
50MP0004147_increased_porphyrin_level1.28602687
51MP0008877_abnormal_DNA_methylation1.26648519
52MP0003633_abnormal_nervous_system1.25227041
53MP0000751_myopathy1.19818237
54MP0001905_abnormal_dopamine_level1.17453264
55MP0005409_darkened_coat_color1.15873818
56MP0004215_abnormal_myocardial_fiber1.15658625
57MP0002152_abnormal_brain_morphology1.10457633
58MP0003631_nervous_system_phenotype1.09790981
59MP0004742_abnormal_vestibular_system1.08546718
60MP0004484_altered_response_of1.05430719
61MP0003123_paternal_imprinting1.04218919
62MP0004085_abnormal_heartbeat1.00831180
63MP0003122_maternal_imprinting0.98370569
64MP0008872_abnormal_physiological_respon0.97657765
65MP0005551_abnormal_eye_electrophysiolog0.95514946
66MP0003283_abnormal_digestive_organ0.94984904
67MP0002229_neurodegeneration0.93415035
68MP0000579_abnormal_nail_morphology0.90476992
69MP0010386_abnormal_urinary_bladder0.90072475
70MP0003941_abnormal_skin_development0.89595010
71MP0002069_abnormal_eating/drinking_beha0.89113918
72MP0008874_decreased_physiological_sensi0.89075418
73MP0003121_genomic_imprinting0.86440713
74MP0001963_abnormal_hearing_physiology0.85037407
75MP0005535_abnormal_body_temperature0.84979521
76MP0003632_abnormal_nervous_system0.84241243
77MP0000604_amyloidosis0.83943814
78MP0001986_abnormal_taste_sensitivity0.83643713
79MP0003137_abnormal_impulse_conducting0.83215149
80MP0004510_myositis0.81626267
81MP0000013_abnormal_adipose_tissue0.81538636
82MP0000569_abnormal_digit_pigmentation0.81141290
83MP0000631_abnormal_neuroendocrine_gland0.79266012
84MP0005623_abnormal_meninges_morphology0.79194990
85MP0001485_abnormal_pinna_reflex0.77713756
86MP0003890_abnormal_embryonic-extraembry0.76487514
87MP0001177_atelectasis0.76136636
88MP0005499_abnormal_olfactory_system0.74688708
89MP0005394_taste/olfaction_phenotype0.74688708
90MP0002752_abnormal_somatic_nervous0.74573708
91MP0000920_abnormal_myelination0.74328263
92MP0003634_abnormal_glial_cell0.74155523
93MP0001299_abnormal_eye_distance/0.73138845
94MP0005167_abnormal_blood-brain_barrier0.73002463
95MP0003646_muscle_fatigue0.72707228
96MP0003690_abnormal_glial_cell0.72094576
97MP0002876_abnormal_thyroid_physiology0.70841278
98MP0006292_abnormal_olfactory_placode0.70247846
99MP0010770_preweaning_lethality0.68842542
100MP0002082_postnatal_lethality0.68842542
101MP0004233_abnormal_muscle_weight0.68317690
102MP0003119_abnormal_digestive_system0.68125202
103MP0010768_mortality/aging0.67840267
104MP0003136_yellow_coat_color0.64284458
105MP0005187_abnormal_penis_morphology0.63832696
106MP0002638_abnormal_pupillary_reflex0.63253784
107MP0008057_abnormal_DNA_replication0.62968800
108MP0002090_abnormal_vision0.60961600
109MP0001346_abnormal_lacrimal_gland0.59709209
110MP0003075_altered_response_to0.58627904
111MP0000026_abnormal_inner_ear0.57142266
112MP0004043_abnormal_pH_regulation0.56905420
113MP0001664_abnormal_digestion0.56378776
114MP0004133_heterotaxia0.56062454
115MP0001943_abnormal_respiration0.54532124
116MP0003861_abnormal_nervous_system0.54531961
117MP0002089_abnormal_postnatal_growth/wei0.54419409
118MP0003956_abnormal_body_size0.54276643
119MP0000639_abnormal_adrenal_gland0.54246006
120MP0005620_abnormal_muscle_contractility0.53993690
121MP0005171_absent_coat_pigmentation0.53545741
122MP0002234_abnormal_pharynx_morphology0.53151023
123MP0002751_abnormal_autonomic_nervous0.52270183
124MP0010769_abnormal_survival0.51086442
125MP0006072_abnormal_retinal_apoptosis0.50799086

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.50295365
2Focal seizures (HP:0007359)6.11730718
3Myokymia (HP:0002411)5.84566226
4Atonic seizures (HP:0010819)5.43527401
5Visual hallucinations (HP:0002367)5.34996744
6Epileptic encephalopathy (HP:0200134)4.97086667
7Absence seizures (HP:0002121)4.78847346
8Febrile seizures (HP:0002373)4.78626282
9Progressive cerebellar ataxia (HP:0002073)4.44578723
10Hyperventilation (HP:0002883)4.42199943
11Dialeptic seizures (HP:0011146)4.37947952
12Broad-based gait (HP:0002136)4.31927397
13Limb dystonia (HP:0002451)4.09171163
14Generalized tonic-clonic seizures (HP:0002069)4.06435655
15Action tremor (HP:0002345)3.96086147
16Gaze-evoked nystagmus (HP:0000640)3.67852407
17Poor eye contact (HP:0000817)3.51435325
18Dysdiadochokinesis (HP:0002075)3.50113862
19Dysmetria (HP:0001310)3.36034424
20Truncal ataxia (HP:0002078)3.28205890
21Cerebral inclusion bodies (HP:0100314)3.19841095
22Drooling (HP:0002307)3.19423861
23Excessive salivation (HP:0003781)3.19423861
24Impaired social interactions (HP:0000735)3.19245141
25Abnormal social behavior (HP:0012433)3.19245141
26Supranuclear gaze palsy (HP:0000605)3.18820589
27Abnormality of the labia minora (HP:0012880)3.11930271
28Amblyopia (HP:0000646)3.11917814
29Anxiety (HP:0000739)3.10734316
30Scanning speech (HP:0002168)3.06803025
31Abnormality of binocular vision (HP:0011514)3.06599753
32Diplopia (HP:0000651)3.06599753
33Hemiparesis (HP:0001269)3.02691395
34Impaired smooth pursuit (HP:0007772)3.00935964
35Neurofibrillary tangles (HP:0002185)2.96803441
36Impaired vibration sensation in the lower limbs (HP:0002166)2.95598940
37Cerebral hypomyelination (HP:0006808)2.87019614
38Depression (HP:0000716)2.84493667
39Absent speech (HP:0001344)2.75968955
40Progressive inability to walk (HP:0002505)2.74669223
41Epileptiform EEG discharges (HP:0011182)2.72946607
42Abnormal eating behavior (HP:0100738)2.71343568
43Mutism (HP:0002300)2.66403096
44Abnormality of ocular smooth pursuit (HP:0000617)2.59243096
45Akinesia (HP:0002304)2.57612872
46Genetic anticipation (HP:0003743)2.57192106
47Status epilepticus (HP:0002133)2.53851271
48Intention tremor (HP:0002080)2.52552449
49Urinary bladder sphincter dysfunction (HP:0002839)2.52484104
50Dysmetric saccades (HP:0000641)2.50077065
51Stereotypic behavior (HP:0000733)2.49513097
52Protruding tongue (HP:0010808)2.47705978
53EEG with generalized epileptiform discharges (HP:0011198)2.47597279
54Sleep apnea (HP:0010535)2.46158833
55Peripheral hypomyelination (HP:0007182)2.43998549
56Hepatoblastoma (HP:0002884)2.42571052
57Postural instability (HP:0002172)2.42499084
58Abnormality of the lower motor neuron (HP:0002366)2.41526562
59Inability to walk (HP:0002540)2.37290583
60Obstructive sleep apnea (HP:0002870)2.37156440
61Morphological abnormality of the pyramidal tract (HP:0002062)2.35329547
62Hemiplegia (HP:0002301)2.35019196
63Tetraplegia (HP:0002445)2.32856424
64Abnormality of the corticospinal tract (HP:0002492)2.32080755
65Termporal pattern (HP:0011008)2.31684632
66Insidious onset (HP:0003587)2.31684632
67Amyotrophic lateral sclerosis (HP:0007354)2.30576289
68Ankle clonus (HP:0011448)2.27309360
69Hypsarrhythmia (HP:0002521)2.26095305
70Spastic gait (HP:0002064)2.24878770
71Urinary urgency (HP:0000012)2.22969796
72Fetal akinesia sequence (HP:0001989)2.22953058
73Blue irides (HP:0000635)2.22507199
74Abnormality of salivation (HP:0100755)2.17432769
75Bradykinesia (HP:0002067)2.15600540
76Generalized myoclonic seizures (HP:0002123)2.14432019
77Psychosis (HP:0000709)2.08887017
78Alacrima (HP:0000522)2.06922752
79Delusions (HP:0000746)2.04272440
80Gait ataxia (HP:0002066)2.03996262
81Polyphagia (HP:0002591)1.99138915
82Impaired vibratory sensation (HP:0002495)1.98585700
83Neuronal loss in central nervous system (HP:0002529)1.97920574
84Inappropriate behavior (HP:0000719)1.97343943
85Craniofacial dystonia (HP:0012179)1.97073055
86Septo-optic dysplasia (HP:0100842)1.93984796
87Incomplete penetrance (HP:0003829)1.93920629
88Torticollis (HP:0000473)1.90798726
89Lower limb asymmetry (HP:0100559)1.89147576
90Congenital sensorineural hearing impairment (HP:0008527)1.88917210
91Pheochromocytoma (HP:0002666)1.88387234
92CNS hypomyelination (HP:0003429)1.88232264
93Lower limb muscle weakness (HP:0007340)1.85633612
94Papilledema (HP:0001085)1.84580275
95Horizontal nystagmus (HP:0000666)1.84446416
96Fair hair (HP:0002286)1.83909344
97Annular pancreas (HP:0001734)1.82600980
98Syncope (HP:0001279)1.82042479
99Optic nerve hypoplasia (HP:0000609)1.81898298
100Focal dystonia (HP:0004373)1.81843680
101Retinal dysplasia (HP:0007973)1.81152203
102Apathy (HP:0000741)1.81020564
103Hydroureter (HP:0000072)1.81016593
104Thickened helices (HP:0000391)1.80412005
105Generalized hypopigmentation of hair (HP:0011358)1.78859933
106Ventricular fibrillation (HP:0001663)1.77245889
107Spastic tetraplegia (HP:0002510)1.75645959
108Aplasia involving bones of the upper limbs (HP:0009823)1.75553311
109Aplasia of the phalanges of the hand (HP:0009802)1.75553311
110Aplasia involving bones of the extremities (HP:0009825)1.75553311
111Megalencephaly (HP:0001355)1.75188302
112Abnormal EKG (HP:0003115)1.75054015
113Agitation (HP:0000713)1.74789709
114Clumsiness (HP:0002312)1.74521679
115Rigidity (HP:0002063)1.73663311
116Increased circulating renin level (HP:0000848)1.73352456
117Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73110374
118Degeneration of the lateral corticospinal tracts (HP:0002314)1.73110374
119Rapidly progressive (HP:0003678)1.72988133
120Clonus (HP:0002169)1.72875928
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72472824
122Spastic tetraparesis (HP:0001285)1.72149809
123Gait imbalance (HP:0002141)1.72037985
124Lower limb amyotrophy (HP:0007210)1.71364912
125Autism (HP:0000717)1.70733758
126Turricephaly (HP:0000262)1.68397652
127Choreoathetosis (HP:0001266)1.68300796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.31403021
2NTRK34.66679479
3RIPK43.45755209
4MAP3K93.19477705
5MAP3K42.91852253
6CASK2.73467567
7MARK12.67268143
8MINK12.50009319
9MAP2K72.48935130
10PNCK2.23677580
11NTRK22.17997223
12DAPK22.14737325
13MAP3K122.04630701
14MAP2K41.90934054
15TNIK1.75652162
16PAK61.71118209
17PLK21.69275692
18KSR21.68556838
19NTRK11.66077465
20KSR11.65114857
21DAPK11.61023903
22SIK21.60655575
23BMPR21.53627589
24CDK51.43653849
25FES1.41788306
26CAMKK11.41459508
27GRK51.37133228
28CAMKK21.37021601
29PRPF4B1.36191081
30PKN11.34674483
31CDK191.31800065
32PRKCG1.28311801
33MAPK131.28114670
34ARAF1.25856519
35TYRO31.17633214
36* CAMK2A1.17040929
37MAP3K131.14633616
38PTK2B1.09532991
39RIPK11.07162198
40STK381.06965262
41NME11.00575364
42PRKD31.00004315
43GRK70.95928630
44* CAMK2B0.92895873
45DYRK20.91023911
46UHMK10.88732311
47OXSR10.87911986
48ALK0.86357398
49MKNK20.86203532
50RAF10.85661932
51FGR0.84957971
52DYRK1A0.84258552
53CAMK10.81844696
54PHKG10.80625147
55PHKG20.80625147
56CDK180.80304273
57CDK150.77867223
58SGK2230.77230282
59SGK4940.77230282
60SGK10.76770687
61STK110.75672457
62CDK140.75536791
63MAP3K20.75359322
64SGK20.72693981
65AKT30.68438357
66PDGFRA0.67217990
67PAK30.66765742
68CDK11A0.66754803
69PRKCE0.64147623
70PINK10.63319622
71CSNK1G10.60397178
72WNK10.58549550
73FGFR20.57342531
74RET0.55510461
75MAPKAPK50.54788486
76TSSK60.53978314
77* CAMK2D0.53936726
78LATS20.53330368
79CSNK1G30.53159606
80CAMK1G0.52734901
81ROCK20.51518627
82MARK20.51168495
83CSNK1A1L0.50654436
84PRKCH0.49787787
85FER0.48600815
86TNK20.47653349
87SGK30.46665412
88MAP3K60.46626453
89PRKCZ0.46441497
90CCNB10.46383494
91PDPK10.46197341
92ROCK10.46128335
93PDK10.45978208
94CSNK1G20.45711706
95FYN0.45341089
96RPS6KA30.44317579
97MAPK120.43844427
98MAPK100.42099659
99INSRR0.41670780
100MUSK0.41334713
101BCR0.40642261
102PRKG10.40208100
103CSNK1D0.40185856
104CAMK40.40137567
105NEK60.39177480
106CSNK1E0.38404763
107PRKDC0.38332691
108DMPK0.38029250
109MAP3K70.37718788
110BRAF0.37342349
111* PRKACA0.37340254
112PLK30.37119504
113WNK30.35573297
114MAP2K10.34974916
115MAP3K10.33879412
116SIK30.33735655
117* CAMK2G0.33169906
118ADRBK10.32750721
119PRKCB0.32459882
120PRKCA0.30243311
121RPS6KB10.29898494

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52802509
2Long-term potentiation_Homo sapiens_hsa047203.06275546
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.01060069
4Glutamatergic synapse_Homo sapiens_hsa047242.82134118
5Circadian entrainment_Homo sapiens_hsa047132.79442910
6GABAergic synapse_Homo sapiens_hsa047272.75296521
7Synaptic vesicle cycle_Homo sapiens_hsa047212.73694536
8Morphine addiction_Homo sapiens_hsa050322.64152158
9Amphetamine addiction_Homo sapiens_hsa050312.62887385
10Olfactory transduction_Homo sapiens_hsa047402.40427521
11Salivary secretion_Homo sapiens_hsa049702.38723115
12Taste transduction_Homo sapiens_hsa047422.23247273
13Dopaminergic synapse_Homo sapiens_hsa047282.21685441
14Long-term depression_Homo sapiens_hsa047302.07375692
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06027626
16Renin secretion_Homo sapiens_hsa049241.93636165
17Gastric acid secretion_Homo sapiens_hsa049711.88225379
18Insulin secretion_Homo sapiens_hsa049111.84036960
19Calcium signaling pathway_Homo sapiens_hsa040201.82931889
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77273132
21* Serotonergic synapse_Homo sapiens_hsa047261.75426076
22Cholinergic synapse_Homo sapiens_hsa047251.74769482
23Oxytocin signaling pathway_Homo sapiens_hsa049211.72154168
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64883514
25Cocaine addiction_Homo sapiens_hsa050301.57100905
26Collecting duct acid secretion_Homo sapiens_hsa049661.51567258
27GnRH signaling pathway_Homo sapiens_hsa049121.41641467
28Gap junction_Homo sapiens_hsa045401.36820917
29Cardiac muscle contraction_Homo sapiens_hsa042601.36434053
30cAMP signaling pathway_Homo sapiens_hsa040241.34665505
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26256500
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25447032
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23409946
34Vitamin B6 metabolism_Homo sapiens_hsa007501.22003679
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20980365
36Axon guidance_Homo sapiens_hsa043601.11532284
37Estrogen signaling pathway_Homo sapiens_hsa049151.11326083
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10221979
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08840974
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07246836
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07016117
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03072167
43Pancreatic secretion_Homo sapiens_hsa049721.02112468
44Alzheimers disease_Homo sapiens_hsa050101.00880844
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99607747
46Type II diabetes mellitus_Homo sapiens_hsa049300.99251745
47Melanogenesis_Homo sapiens_hsa049160.98132373
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.95471918
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95082828
50Glioma_Homo sapiens_hsa052140.94055282
51Vibrio cholerae infection_Homo sapiens_hsa051100.89576998
52Phototransduction_Homo sapiens_hsa047440.86651395
53ErbB signaling pathway_Homo sapiens_hsa040120.84701828
54Oxidative phosphorylation_Homo sapiens_hsa001900.84032484
55Dilated cardiomyopathy_Homo sapiens_hsa054140.83138407
56Thyroid hormone synthesis_Homo sapiens_hsa049180.81469019
57Oocyte meiosis_Homo sapiens_hsa041140.81320648
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.78432703
59Choline metabolism in cancer_Homo sapiens_hsa052310.74315574
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70249224
61Fatty acid biosynthesis_Homo sapiens_hsa000610.69993569
62MAPK signaling pathway_Homo sapiens_hsa040100.66478264
63VEGF signaling pathway_Homo sapiens_hsa043700.63664649
64Dorso-ventral axis formation_Homo sapiens_hsa043200.63242948
65African trypanosomiasis_Homo sapiens_hsa051430.61469067
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60032505
67Parkinsons disease_Homo sapiens_hsa050120.58213906
68Glucagon signaling pathway_Homo sapiens_hsa049220.57468581
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56463909
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56084007
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53926525
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53632011
73Inositol phosphate metabolism_Homo sapiens_hsa005620.52944977
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52295044
75Hippo signaling pathway_Homo sapiens_hsa043900.52187951
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51698279
77Rap1 signaling pathway_Homo sapiens_hsa040150.50585216
78Ras signaling pathway_Homo sapiens_hsa040140.49422794
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.45443933
80Huntingtons disease_Homo sapiens_hsa050160.44701662
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43497997
82Circadian rhythm_Homo sapiens_hsa047100.43073218
83Tight junction_Homo sapiens_hsa045300.42949412
84Bile secretion_Homo sapiens_hsa049760.42777464
85Alcoholism_Homo sapiens_hsa050340.41837821
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.39161600
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38468935
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36659689
89Wnt signaling pathway_Homo sapiens_hsa043100.36568525
90Type I diabetes mellitus_Homo sapiens_hsa049400.36453201
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35936336
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33274966
93Prion diseases_Homo sapiens_hsa050200.31858519
94beta-Alanine metabolism_Homo sapiens_hsa004100.31256962
95Histidine metabolism_Homo sapiens_hsa003400.29176476
96Ovarian steroidogenesis_Homo sapiens_hsa049130.29135440
97mTOR signaling pathway_Homo sapiens_hsa041500.28037809
98Non-small cell lung cancer_Homo sapiens_hsa052230.28017498
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27559616
100Renal cell carcinoma_Homo sapiens_hsa052110.27532192
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26975821
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26535183
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25406095
104Mineral absorption_Homo sapiens_hsa049780.25008099
105Nitrogen metabolism_Homo sapiens_hsa009100.24988328
106Colorectal cancer_Homo sapiens_hsa052100.24179604
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23116177
108Ether lipid metabolism_Homo sapiens_hsa005650.21870399
109Endocytosis_Homo sapiens_hsa041440.21559831
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21453118
111Arginine and proline metabolism_Homo sapiens_hsa003300.20919617
112Chemokine signaling pathway_Homo sapiens_hsa040620.20546602
113Arginine biosynthesis_Homo sapiens_hsa002200.20495245
114Insulin signaling pathway_Homo sapiens_hsa049100.19759505
115Endometrial cancer_Homo sapiens_hsa052130.19497238

Most similar genes based on co-expression Upload to Enrichr

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