KCNE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)9.09270701
2synaptonemal complex assembly (GO:0007130)8.63434969
3chromosome organization involved in meiosis (GO:0070192)8.43857888
4piRNA metabolic process (GO:0034587)8.36440836
5synaptonemal complex organization (GO:0070193)7.75520752
6male meiosis (GO:0007140)7.52799951
7male meiosis I (GO:0007141)7.02389719
8DNA methylation involved in gamete generation (GO:0043046)6.87028668
9surfactant homeostasis (GO:0043129)6.64403157
10resolution of meiotic recombination intermediates (GO:0000712)6.33233505
11DNA synthesis involved in DNA repair (GO:0000731)5.86063639
12substrate-independent telencephalic tangential migration (GO:0021826)5.85237083
13substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.85237083
14meiosis I (GO:0007127)5.79730484
15meiotic nuclear division (GO:0007126)5.73178346
16positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.60669753
17positive regulation of guanylate cyclase activity (GO:0031284)5.52772816
18negative regulation of complement activation (GO:0045916)5.48138716
19chemical homeostasis within a tissue (GO:0048875)5.17110837
20regulation of rhodopsin mediated signaling pathway (GO:0022400)5.16165539
21positive regulation of respiratory burst (GO:0060267)5.10274448
22retinal cone cell development (GO:0046549)5.10229325
23regulation of meiosis I (GO:0060631)5.08356049
24rhodopsin mediated signaling pathway (GO:0016056)5.07446800
25meiotic cell cycle process (GO:1903046)4.92881845
26regulation of guanylate cyclase activity (GO:0031282)4.89493886
27phototransduction, visible light (GO:0007603)4.78700988
28central nervous system myelination (GO:0022010)4.77575347
29axon ensheathment in central nervous system (GO:0032291)4.77575347
30photoreceptor cell development (GO:0042461)4.76059980
31retinal rod cell development (GO:0046548)4.72074378
32phototransduction (GO:0007602)4.65180312
33eye photoreceptor cell development (GO:0042462)4.60660863
34negative regulation of protein activation cascade (GO:2000258)4.55458562
35detection of visible light (GO:0009584)4.52480534
36detection of light stimulus (GO:0009583)4.44271252
37presynaptic membrane organization (GO:0097090)4.43379722
38retinol metabolic process (GO:0042572)4.35572871
39cGMP biosynthetic process (GO:0006182)4.09260760
40cellular copper ion homeostasis (GO:0006878)4.08957246
41sodium-independent organic anion transport (GO:0043252)4.06505745
42hypotonic response (GO:0006971)4.00220123
43mitochondrion distribution (GO:0048311)3.98036003
44detection of light stimulus involved in visual perception (GO:0050908)3.97241025
45detection of light stimulus involved in sensory perception (GO:0050962)3.97241025
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.97120353
47negative regulation of humoral immune response (GO:0002921)3.96800933
48regulation of phospholipid biosynthetic process (GO:0071071)3.92504101
49regulation of cardioblast proliferation (GO:0003264)3.92212150
50regulation of secondary heart field cardioblast proliferation (GO:0003266)3.92212150
51neuronal ion channel clustering (GO:0045161)3.83135049
52regulation of cardioblast differentiation (GO:0051890)3.80476893
53folic acid transport (GO:0015884)3.70677409
54omega-hydroxylase P450 pathway (GO:0097267)3.62721420
55prostate gland growth (GO:0060736)3.57012499
56detection of temperature stimulus (GO:0016048)3.49194306
57regulation of transforming growth factor beta2 production (GO:0032909)3.48614120
58positive regulation of cGMP biosynthetic process (GO:0030828)3.48136022
59proteasome assembly (GO:0043248)3.41248238
60binding of sperm to zona pellucida (GO:0007339)3.39355591
61female gamete generation (GO:0007292)3.38916740
62sister chromatid cohesion (GO:0007062)3.37873773
63detection of external stimulus (GO:0009581)3.36587510
64receptor catabolic process (GO:0032801)3.36478780
65photoreceptor cell maintenance (GO:0045494)3.34152256
66glycerophospholipid catabolic process (GO:0046475)3.33297823
67negative regulation of epidermis development (GO:0045683)3.31453284
68amyloid precursor protein catabolic process (GO:0042987)3.30919037
69pathway-restricted SMAD protein phosphorylation (GO:0060389)3.30436172
70regulation of oxidative stress-induced neuron death (GO:1903203)3.30140366
71regulation of cGMP metabolic process (GO:0030823)3.27730930
72vitamin transmembrane transport (GO:0035461)3.26709983
73detection of abiotic stimulus (GO:0009582)3.25515303
74reciprocal DNA recombination (GO:0035825)3.23777092
75reciprocal meiotic recombination (GO:0007131)3.23777092
76gland morphogenesis (GO:0022612)3.22539570
77regulation of cGMP biosynthetic process (GO:0030826)3.20834276
78response to acidic pH (GO:0010447)3.19300297
79acrosome reaction (GO:0007340)3.15929060
80photoreceptor cell differentiation (GO:0046530)3.13448707
81eye photoreceptor cell differentiation (GO:0001754)3.13448707
82positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.13061964
83positive regulation of cGMP metabolic process (GO:0030825)3.10090303
84oogenesis (GO:0048477)3.09692747
85spermatid development (GO:0007286)3.09374045
86DNA double-strand break processing (GO:0000729)3.08551317
87bicarbonate transport (GO:0015701)3.08377888
88copper ion homeostasis (GO:0055070)3.07874150
89thalamus development (GO:0021794)3.07546445
90cGMP metabolic process (GO:0046068)3.05203256
91negative regulation of epidermal cell differentiation (GO:0045605)3.02623211
92visual perception (GO:0007601)3.02390648
93regulation of dopamine secretion (GO:0014059)3.01176434
94muscle cell fate commitment (GO:0042693)2.99994322
95valine metabolic process (GO:0006573)2.99464266
96peroxisome fission (GO:0016559)2.98248717
97sensory perception of light stimulus (GO:0050953)2.97705364
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.97400015
99retina development in camera-type eye (GO:0060041)2.97211251
100positive regulation of meiotic cell cycle (GO:0051446)2.94741605
101positive regulation of meiosis (GO:0045836)2.93472784
102neuron remodeling (GO:0016322)2.92543583
103lung vasculature development (GO:0060426)2.92179257
104meiotic chromosome segregation (GO:0045132)2.91937222
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.90538339
106epithelial cilium movement (GO:0003351)2.90214841
107meiotic cell cycle (GO:0051321)2.88954481
108phenylpropanoid metabolic process (GO:0009698)2.83960544
109paraxial mesoderm development (GO:0048339)2.83307309
110positive regulation of catecholamine secretion (GO:0033605)2.83069390
111histone exchange (GO:0043486)2.82450736
112cellular potassium ion homeostasis (GO:0030007)2.82194741
113regulation of oxidative phosphorylation (GO:0002082)2.82059971
114DNA alkylation (GO:0006305)2.81367023
115DNA methylation (GO:0006306)2.81367023
116regulation of meiotic cell cycle (GO:0051445)2.81115161
117gene silencing by RNA (GO:0031047)2.81093216
118cardiac muscle cell proliferation (GO:0060038)2.80902867
119primary alcohol metabolic process (GO:0034308)2.80318882
120mitochondrion degradation (GO:0000422)2.78961376
121substrate-dependent cell migration (GO:0006929)2.76428464
122lung epithelium development (GO:0060428)2.75804300
123retinoid metabolic process (GO:0001523)2.73373574
124phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.73264252
125myoblast migration (GO:0051451)2.73141119
126regulation of hydrogen peroxide-induced cell death (GO:1903205)2.72631005
127negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72002447
128regulation of alkaline phosphatase activity (GO:0010692)2.70401773
129regulation of macrophage cytokine production (GO:0010935)2.68750098
130mating behavior (GO:0007617)2.68283429
131negative regulation of macroautophagy (GO:0016242)2.68062723
132regulation of beta-amyloid formation (GO:1902003)2.67928743
133fertilization (GO:0009566)2.67287518
134synaptic vesicle maturation (GO:0016188)2.66815643
135C21-steroid hormone biosynthetic process (GO:0006700)2.64670381
136layer formation in cerebral cortex (GO:0021819)2.64504202
137cell volume homeostasis (GO:0006884)2.64118390
138fatty acid elongation (GO:0030497)2.63347577
139protein-chromophore linkage (GO:0018298)2.61982765
140germ cell development (GO:0007281)2.60678371
141negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.59809397
142auditory behavior (GO:0031223)2.58556826
143regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58522417
144GMP metabolic process (GO:0046037)2.58030899
145reproductive system development (GO:0061458)2.57579272
146ventricular system development (GO:0021591)2.57076006
147response to misfolded protein (GO:0051788)2.56790833
148protein localization to endosome (GO:0036010)2.56534565
149positive regulation of mitochondrial fission (GO:0090141)2.56129794
150phospholipid translocation (GO:0045332)2.55716809
151lipid translocation (GO:0034204)2.55716809
152genitalia morphogenesis (GO:0035112)2.55139824
153cranial nerve morphogenesis (GO:0021602)2.54573146
154outer ear morphogenesis (GO:0042473)2.54479474
155cilium movement (GO:0003341)2.54396261
156behavioral response to nicotine (GO:0035095)2.53204196
157peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.52681247
158regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51232814
159diterpenoid metabolic process (GO:0016101)2.51062844
160fatty acid transmembrane transport (GO:1902001)2.50677289
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50475019
162multicellular organism reproduction (GO:0032504)2.49721546
163innervation (GO:0060384)2.49265626
164cerebellar Purkinje cell differentiation (GO:0021702)2.49164901
165mammary gland alveolus development (GO:0060749)2.49095317
166regulation of autophagic vacuole assembly (GO:2000785)2.48857656
167renal filtration (GO:0097205)2.48752934
168histone H3-K36 demethylation (GO:0070544)2.48349074
169glomerular filtration (GO:0003094)2.47806419
170protein autoprocessing (GO:0016540)2.47067114
171cellular response to light stimulus (GO:0071482)2.46763538
172motile cilium assembly (GO:0044458)2.46686962
173polyamine biosynthetic process (GO:0006596)2.45393968
174sperm-egg recognition (GO:0035036)2.44907144
175regulation of synapse structural plasticity (GO:0051823)2.43859433
176negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.43785007
177cochlea development (GO:0090102)2.43708772
178vitamin transport (GO:0051180)2.43194168
179lung lobe morphogenesis (GO:0060463)2.42583066
180locomotory exploration behavior (GO:0035641)2.42453738
181head development (GO:0060322)2.41315921
182axonemal dynein complex assembly (GO:0070286)2.39706697
183embryonic digestive tract development (GO:0048566)2.39278885
184tooth mineralization (GO:0034505)2.38161179
185sperm motility (GO:0030317)2.37080840
186histone H3-K9 demethylation (GO:0033169)2.36646894
187protein retention in ER lumen (GO:0006621)2.35193629
188cytoskeletal anchoring at plasma membrane (GO:0007016)2.34839364
189regulation of acrosome reaction (GO:0060046)2.34404968
190negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.33039309
191sex differentiation (GO:0007548)2.32599588
192positive regulation of gastrulation (GO:2000543)2.31352534
193intraciliary transport (GO:0042073)2.30996544
194embryonic camera-type eye development (GO:0031076)2.28712288
195regulation of meiosis (GO:0040020)2.27813604
196regulation of inclusion body assembly (GO:0090083)2.24121461
197cellular response to pH (GO:0071467)2.23406520
198adult walking behavior (GO:0007628)2.18544609
199ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.17419662
200male gamete generation (GO:0048232)2.15874931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49314190
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.47878170
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.95992596
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98738268
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.81577771
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69174555
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48510629
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.27218411
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.26766187
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24654770
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24654770
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.23362605
13RNF2_27304074_Chip-Seq_NSC_Mouse2.18659414
14DROSHA_22980978_ChIP-Seq_HELA_Human2.15509588
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10711484
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10470581
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07137027
18* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06921651
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06319651
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04316900
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01754564
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.99060926
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.97964524
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94132749
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92359529
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90609877
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88084428
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.87277033
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.81856390
30ZNF274_21170338_ChIP-Seq_K562_Hela1.77272229
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76667482
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75354344
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74022687
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.73936709
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68048443
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66975912
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65310889
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.64586028
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.64167309
40DCP1A_22483619_ChIP-Seq_HELA_Human1.62754873
41GABP_19822575_ChIP-Seq_HepG2_Human1.62684744
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61251666
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59235812
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57997088
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57736681
46IGF1R_20145208_ChIP-Seq_DFB_Human1.56555940
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53797535
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51301741
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51157095
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50034152
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.49788787
52CLOCK_20551151_ChIP-Seq_293T_Human1.49042708
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.48947552
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48535642
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.48396839
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.45351548
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.44288344
58* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43123449
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41843646
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41191256
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38285753
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38076884
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.36944301
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36778014
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34929446
66ERA_21632823_ChIP-Seq_H3396_Human1.34765870
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.34564756
68FUS_26573619_Chip-Seq_HEK293_Human1.32058012
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29505517
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29128870
71AHR_22903824_ChIP-Seq_MCF-7_Human1.28421719
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27301427
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27194340
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25884746
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24963307
76KDM2B_26808549_Chip-Seq_K562_Human1.24529759
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.24342067
78MYC_18940864_ChIP-ChIP_HL60_Human1.23129952
79SOX2_20726797_ChIP-Seq_SW620_Human1.21932824
80XRN2_22483619_ChIP-Seq_HELA_Human1.21813377
81* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21594494
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20342351
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20131869
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.19740853
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18961645
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.18125345
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17570116
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16758537
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15611126
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15315687
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.14524484
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.14319468
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13736718
94GBX2_23144817_ChIP-Seq_PC3_Human1.13628934
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12806763
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12452684
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.11232646
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10680138
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.10466159
100CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10279829
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10126285
102KDM5A_27292631_Chip-Seq_BREAST_Human1.09387083
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.08978488
104NANOG_20526341_ChIP-Seq_ESCs_Human1.08895631
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.07767959
106SMC4_20622854_ChIP-Seq_HELA_Human1.07592747
107SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07142636
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06512607
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05424013
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.05380071
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04604487
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04482563
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04418174
114MYC_19829295_ChIP-Seq_ESCs_Human1.04223348
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03479996
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03247266
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03188124
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03019777
119AR_21572438_ChIP-Seq_LNCaP_Human1.02603403
120SMAD_19615063_ChIP-ChIP_OVARY_Human1.02463961
121BCAT_22108803_ChIP-Seq_LS180_Human1.02240561
122CTCF_27219007_Chip-Seq_Bcells_Human1.01867187
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00783120
124P68_20966046_ChIP-Seq_HELA_Human0.99472238
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.99322618
126ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99039198
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98530358
128TTF2_22483619_ChIP-Seq_HELA_Human0.97603770
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97538649
130SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97418923
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.97347035
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.96704580
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96344551
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96344551
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96344551
136SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96226457
137HTT_18923047_ChIP-ChIP_STHdh_Human0.96103433
138MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95968505
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95376299
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94838186
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94771497
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94728342
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94529517
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94370383
145* ISL1_27105846_Chip-Seq_CPCs_Mouse0.94261399
146* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94201384
147* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94201384
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94156072
149REST_21632747_ChIP-Seq_MESCs_Mouse0.94146622
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93450099
151OCT4_20526341_ChIP-Seq_ESCs_Human0.92397503
152TCF4_22108803_ChIP-Seq_LS180_Human0.91621534
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91594542
154LXR_22158963_ChIP-Seq_LIVER_Mouse0.91094213
155SMAD4_21799915_ChIP-Seq_A2780_Human0.91083845
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91053364
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90535589
158CBP_20019798_ChIP-Seq_JUKART_Human0.90535589
159TP53_18474530_ChIP-ChIP_U2OS_Human0.89979402
160AR_19668381_ChIP-Seq_PC3_Human0.89977289
161FOXA2_19822575_ChIP-Seq_HepG2_Human0.89789347
162MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89401290
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89270021
164* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88702479
165* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88245812
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87933854
167RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87905563
168SOX2_21211035_ChIP-Seq_LN229_Gbm0.87797024
169EZH2_27304074_Chip-Seq_ESCs_Mouse0.87603291
170RING1B_27294783_Chip-Seq_ESCs_Mouse0.87332687
171PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86744336
172CTCF_20526341_ChIP-Seq_ESCs_Human0.86742637
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85744269
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.85632800
175PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85581727
176BCL6_27268052_Chip-Seq_Bcells_Human0.85567799
177TP53_16413492_ChIP-PET_HCT116_Human0.85355387
178SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84298260
179KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83973469
180SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83452359
181PHF8_20622854_ChIP-Seq_HELA_Human0.82984154
182FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78920326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation8.31134307
2MP0005423_abnormal_somatic_nervous5.18615999
3MP0008877_abnormal_DNA_methylation5.12076325
4MP0005551_abnormal_eye_electrophysiolog5.01711659
5MP0001958_emphysema4.55829895
6MP0002822_catalepsy4.52215263
7MP0004019_abnormal_vitamin_homeostasis3.74618478
8* MP0008004_abnormal_stomach_pH3.42320469
9MP0005253_abnormal_eye_physiology3.18633059
10MP0006072_abnormal_retinal_apoptosis3.15827415
11MP0002160_abnormal_reproductive_system3.14635713
12MP0004782_abnormal_surfactant_physiolog3.02805861
13MP0003315_abnormal_perineum_morphology2.85240036
14MP0001346_abnormal_lacrimal_gland2.70493526
15MP0002210_abnormal_sex_determination2.69576393
16MP0001929_abnormal_gametogenesis2.39606699
17MP0003693_abnormal_embryo_hatching2.39169349
18MP0001177_atelectasis2.37075255
19MP0005410_abnormal_fertilization2.19565349
20MP0003698_abnormal_male_reproductive2.12927037
21MP0001188_hyperpigmentation2.12245383
22MP0005248_abnormal_Harderian_gland2.10523565
23MP0003718_maternal_effect2.09262815
24MP0001324_abnormal_eye_pigmentation2.05868446
25MP0001145_abnormal_male_reproductive2.04958852
26MP0008438_abnormal_cutaneous_collagen1.94819015
27MP0005195_abnormal_posterior_eye1.93942032
28MP0004272_abnormal_basement_membrane1.93672366
29MP0008058_abnormal_DNA_repair1.89559670
30MP0005187_abnormal_penis_morphology1.88216758
31MP0003950_abnormal_plasma_membrane1.88165977
32MP0000653_abnormal_sex_gland1.87921954
33MP0003329_amyloid_beta_deposits1.87346762
34MP0005666_abnormal_adipose_tissue1.86853213
35MP0002090_abnormal_vision1.84729460
36MP0000049_abnormal_middle_ear1.82654995
37MP0005389_reproductive_system_phenotype1.81685089
38MP0008789_abnormal_olfactory_epithelium1.75644295
39MP0005499_abnormal_olfactory_system1.74522596
40MP0005394_taste/olfaction_phenotype1.74522596
41MP0000566_synostosis1.69259606
42MP0000678_abnormal_parathyroid_gland1.62931291
43MP0005391_vision/eye_phenotype1.55511508
44MP0000372_irregular_coat_pigmentation1.55463177
45MP0000681_abnormal_thyroid_gland1.52821657
46MP0003136_yellow_coat_color1.49237020
47MP0002229_neurodegeneration1.48809296
48MP0001984_abnormal_olfaction1.45445654
49MP0008875_abnormal_xenobiotic_pharmacok1.43809727
50MP0002295_abnormal_pulmonary_circulatio1.43712167
51MP0001529_abnormal_vocalization1.42516861
52MP0010368_abnormal_lymphatic_system1.40433884
53MP0000604_amyloidosis1.40330975
54MP0008995_early_reproductive_senescence1.40026651
55MP0005167_abnormal_blood-brain_barrier1.39646915
56MP0001661_extended_life_span1.36956692
57MP0002161_abnormal_fertility/fecundity1.34774830
58MP0002971_abnormal_brown_adipose1.33778734
59MP0002108_abnormal_muscle_morphology1.33764320
60MP0002638_abnormal_pupillary_reflex1.33414068
61MP0008932_abnormal_embryonic_tissue1.31745609
62MP0003119_abnormal_digestive_system1.30318000
63MP0001765_abnormal_ion_homeostasis1.29140989
64MP0002133_abnormal_respiratory_system1.28243669
65MP0005388_respiratory_system_phenotype1.28243669
66MP0002928_abnormal_bile_duct1.27404786
67MP0009384_cardiac_valve_regurgitation1.26714738
68MP0001919_abnormal_reproductive_system1.26311211
69MP0006035_abnormal_mitochondrial_morpho1.25124197
70MP0002653_abnormal_ependyma_morphology1.24610973
71MP0005375_adipose_tissue_phenotype1.23672809
72MP0002837_dystrophic_cardiac_calcinosis1.22906218
73MP0003938_abnormal_ear_development1.22654203
74MP0005058_abnormal_lysosome_morphology1.22594354
75MP0003632_abnormal_nervous_system1.17729265
76* MP0001664_abnormal_digestion1.17444368
77MP0001119_abnormal_female_reproductive1.16620918
78MP0006036_abnormal_mitochondrial_physio1.16524327
79MP0003123_paternal_imprinting1.16310517
80MP0006276_abnormal_autonomic_nervous1.15920477
81MP0003806_abnormal_nucleotide_metabolis1.15633911
82MP0005647_abnormal_sex_gland1.14213311
83MP0005646_abnormal_pituitary_gland1.13225075
84MP0003699_abnormal_female_reproductive1.13093267
85MP0002127_abnormal_cardiovascular_syste1.09647879
86MP0002249_abnormal_larynx_morphology1.08606425
87MP0000462_abnormal_digestive_system1.06978049
88MP0006292_abnormal_olfactory_placode1.06615509
89MP0000749_muscle_degeneration1.05474372
90MP0003191_abnormal_cellular_cholesterol1.04756539
91MP0002234_abnormal_pharynx_morphology1.04007249
92MP0001440_abnormal_grooming_behavior1.03787650
93MP0009379_abnormal_foot_pigmentation1.03141924
94MP0004859_abnormal_synaptic_plasticity1.02532513
95MP0000955_abnormal_spinal_cord1.01642496
96MP0005083_abnormal_biliary_tract1.00977557
97MP0003279_aneurysm1.00937376
98MP0001879_abnormal_lymphatic_vessel1.00840419
99MP0000639_abnormal_adrenal_gland1.00454875
100MP0000778_abnormal_nervous_system0.99288145
101MP0002184_abnormal_innervation0.99110274
102MP0002752_abnormal_somatic_nervous0.98131254
103MP0002254_reproductive_system_inflammat0.98093073
104MP0005409_darkened_coat_color0.97473499
105MP0009780_abnormal_chondrocyte_physiolo0.96732538
106MP0000631_abnormal_neuroendocrine_gland0.96446935
107MP0008961_abnormal_basal_metabolism0.95921664
108MP0010030_abnormal_orbit_morphology0.94672082
109MP0009250_abnormal_appendicular_skeleto0.93144831
110MP0000026_abnormal_inner_ear0.92351273
111MP0005197_abnormal_uvea_morphology0.92344970
112MP0003646_muscle_fatigue0.91791141
113MP0003879_abnormal_hair_cell0.91543195
114MP0001502_abnormal_circadian_rhythm0.91478855
115MP0002168_other_aberrant_phenotype0.90461371
116MP0001486_abnormal_startle_reflex0.89695343
117MP0010678_abnormal_skin_adnexa0.87562944
118MP0005275_abnormal_skin_tensile0.87070651
119MP0006054_spinal_hemorrhage0.86492030
120MP0009745_abnormal_behavioral_response0.85709545
121MP0003631_nervous_system_phenotype0.85259240
122MP0003890_abnormal_embryonic-extraembry0.85115560
123MP0010234_abnormal_vibrissa_follicle0.83864404
124MP0005165_increased_susceptibility_to0.83634751
125MP0003252_abnormal_bile_duct0.82851863
126MP0000534_abnormal_ureter_morphology0.81742778
127MP0005379_endocrine/exocrine_gland_phen0.80669248
128MP0004883_abnormal_blood_vessel0.79904859
129MP0003937_abnormal_limbs/digits/tail_de0.79183032
130MP0005408_hypopigmentation0.79117125
131MP0002132_abnormal_respiratory_system0.78301702
132MP0003172_abnormal_lysosome_physiology0.78046729
133MP0002882_abnormal_neuron_morphology0.77354526
134MP0003787_abnormal_imprinting0.77153617
135MP0003634_abnormal_glial_cell0.74207547
136MP0004084_abnormal_cardiac_muscle0.72692105
137MP0001963_abnormal_hearing_physiology0.72156798
138MP0000762_abnormal_tongue_morphology0.72084430
139MP0001881_abnormal_mammary_gland0.70552214
140MP0004036_abnormal_muscle_relaxation0.68754229
141MP0003635_abnormal_synaptic_transmissio0.66729287
142MP0001905_abnormal_dopamine_level0.66533861
143MP0002272_abnormal_nervous_system0.66109345
144MP0003690_abnormal_glial_cell0.65821565
145MP0005535_abnormal_body_temperature0.64992884
146MP0003633_abnormal_nervous_system0.64850585
147* MP0000470_abnormal_stomach_morphology0.63231098
148MP0002116_abnormal_craniofacial_bone0.62912784
149MP0001944_abnormal_pancreas_morphology0.62365819
150MP0002735_abnormal_chemical_nociception0.62266412
151MP0001286_abnormal_eye_development0.62055308
152MP0000733_abnormal_muscle_development0.61853592
153MP0002277_abnormal_respiratory_mucosa0.60661772
154MP0003755_abnormal_palate_morphology0.60192298
155MP0000249_abnormal_blood_vessel0.60097116
156MP0003137_abnormal_impulse_conducting0.59995961
157MP0004885_abnormal_endolymph0.59354551
158MP0002736_abnormal_nociception_after0.58844607
159MP0004811_abnormal_neuron_physiology0.58699798
160MP0005623_abnormal_meninges_morphology0.58696808
161MP0001270_distended_abdomen0.57375021
162MP0003861_abnormal_nervous_system0.57250562
163MP0010386_abnormal_urinary_bladder0.56123026
164MP0003936_abnormal_reproductive_system0.56073460
165MP0002233_abnormal_nose_morphology0.56057873
166MP0000537_abnormal_urethra_morphology0.55774465
167MP0003186_abnormal_redox_activity0.55625284
168MP0002909_abnormal_adrenal_gland0.54438536
169MP0001915_intracranial_hemorrhage0.54322922
170MP0001943_abnormal_respiration0.54163875
171MP0004043_abnormal_pH_regulation0.53356087
172MP0001764_abnormal_homeostasis0.52933363
173MP0002998_abnormal_bone_remodeling0.52703212
174MP0005220_abnormal_exocrine_pancreas0.52131869
175MP0002118_abnormal_lipid_homeostasis0.51410067
176MP0004484_altered_response_of0.50781799
177MP0009840_abnormal_foam_cell0.50542117
178MP0003786_premature_aging0.49398350
179MP0003638_abnormal_response/metabolism_0.49353317
180MP0000230_abnormal_systemic_arterial0.48761735

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.96298316
2Arterial tortuosity (HP:0005116)6.24895454
3Bony spicule pigmentary retinopathy (HP:0007737)5.98513893
4Vascular tortuosity (HP:0004948)5.77799162
5Interstitial pulmonary disease (HP:0006530)5.67857926
6Abnormal rod and cone electroretinograms (HP:0008323)5.64580682
7Central scotoma (HP:0000603)5.35327479
8Abnormality of macular pigmentation (HP:0008002)5.25555566
9Scotoma (HP:0000575)5.22452132
10Vascular calcification (HP:0004934)4.94250844
11Choroideremia (HP:0001139)4.81988165
12Cardiovascular calcification (HP:0011915)4.52477389
13Dyschromatopsia (HP:0007641)4.48993318
14Absent rod-and cone-mediated responses on ERG (HP:0007688)4.48639692
15Increased CSF protein (HP:0002922)4.18060212
16Chorioretinal atrophy (HP:0000533)4.16674623
17Pigmentary retinal degeneration (HP:0001146)4.16426130
18Abolished electroretinogram (ERG) (HP:0000550)4.06627035
19Azoospermia (HP:0000027)3.94404710
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.87801834
21Absent/shortened dynein arms (HP:0200106)3.87801834
22Spondylolisthesis (HP:0003302)3.82137586
23Hypoplasia of the uterus (HP:0000013)3.80563109
24Orthostatic hypotension (HP:0001278)3.78142506
25Cone-rod dystrophy (HP:0000548)3.76807451
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60173895
27Abnormal ciliary motility (HP:0012262)3.58352063
28Abnormal respiratory motile cilium physiology (HP:0012261)3.51864488
29Pendular nystagmus (HP:0012043)3.50606239
30Aortic dissection (HP:0002647)3.41477804
31Aplasia/hypoplasia of the uterus (HP:0008684)3.39813741
32Hemiparesis (HP:0001269)3.27230229
33Abnormality of the fovea (HP:0000493)3.17720676
34Abnormal respiratory motile cilium morphology (HP:0005938)3.12093286
35Abnormal respiratory epithelium morphology (HP:0012253)3.12093286
36Decreased central vision (HP:0007663)3.07801154
37Abnormal number of erythroid precursors (HP:0012131)3.00664702
38Infertility (HP:0000789)2.98396419
39Male infertility (HP:0003251)2.96027787
40Congenital malformation of the right heart (HP:0011723)2.94714064
41Double outlet right ventricle (HP:0001719)2.94714064
42Myokymia (HP:0002411)2.91736870
43Thyroid-stimulating hormone excess (HP:0002925)2.87858887
44Abnormality of renal resorption (HP:0011038)2.81821298
45Hyperphosphatemia (HP:0002905)2.81807202
46Abnormality of cells of the erythroid lineage (HP:0012130)2.80056780
47Rhinitis (HP:0012384)2.79152264
48Megaloblastic anemia (HP:0001889)2.77939587
49Abnormal spermatogenesis (HP:0008669)2.77859333
50Macular degeneration (HP:0000608)2.75206294
51Oligomenorrhea (HP:0000876)2.75053713
52Abnormality of vitamin B metabolism (HP:0004340)2.72446537
53Retinal atrophy (HP:0001105)2.71941939
54Photophobia (HP:0000613)2.69046534
55Male pseudohermaphroditism (HP:0000037)2.68874607
56Subcapsular cataract (HP:0000523)2.62811078
57Posterior subcapsular cataract (HP:0007787)2.62790603
58Sex reversal (HP:0012245)2.62408563
59Abnormal sex determination (HP:0012244)2.62408563
60Facial hemangioma (HP:0000329)2.61665262
61Keratoconus (HP:0000563)2.61597403
62Increased corneal curvature (HP:0100692)2.61597403
63Abnormality of DNA repair (HP:0003254)2.61518968
64Abnormality of the aortic arch (HP:0012303)2.60833711
65Anterior segment dysgenesis (HP:0007700)2.58462400
66Rimmed vacuoles (HP:0003805)2.58228677
67Type II diabetes mellitus (HP:0005978)2.57831011
68Sclerocornea (HP:0000647)2.57352670
69Tachypnea (HP:0002789)2.55779983
70Attenuation of retinal blood vessels (HP:0007843)2.54840424
71Oligodactyly (hands) (HP:0001180)2.54047643
72Abnormality of molar (HP:0011077)2.53682554
73Abnormality of molar morphology (HP:0011070)2.53682554
74Abnormality of the dental root (HP:0006486)2.53598329
75Taurodontia (HP:0000679)2.53598329
76Abnormality of permanent molar morphology (HP:0011071)2.53598329
77Hand muscle atrophy (HP:0009130)2.47457585
78Constricted visual fields (HP:0001133)2.46952569
79Aortic aneurysm (HP:0004942)2.45128748
80Abnormal mitochondria in muscle tissue (HP:0008316)2.42407967
81Severe visual impairment (HP:0001141)2.40212317
82Occipital encephalocele (HP:0002085)2.39674825
83Supernumerary spleens (HP:0009799)2.35052520
84Metaphyseal dysplasia (HP:0100255)2.34868750
85Acute necrotizing encephalopathy (HP:0006965)2.34069136
86Osteomalacia (HP:0002749)2.32554844
87Periauricular skin pits (HP:0100277)2.30468243
88Preauricular pit (HP:0004467)2.30468243
89Hepatoblastoma (HP:0002884)2.29790598
90Cerebral aneurysm (HP:0004944)2.29282354
91Hyperthyroidism (HP:0000836)2.27964946
92Hypotension (HP:0002615)2.27335392
93Abnormality of vitamin metabolism (HP:0100508)2.25188820
94Limb dystonia (HP:0002451)2.23352261
95Type II lissencephaly (HP:0007260)2.22857515
96Tubulointerstitial nephritis (HP:0001970)2.22015849
97Abnormality of the dental pulp (HP:0006479)2.17701262
98Progressive visual loss (HP:0000529)2.15525206
99Chronic bronchitis (HP:0004469)2.14869636
100Abdominal situs inversus (HP:0003363)2.14592422
101Abnormality of abdominal situs (HP:0011620)2.14592422
102Meckel diverticulum (HP:0002245)2.11075539
103Gonadotropin excess (HP:0000837)2.10987692
104Absent thumb (HP:0009777)2.10803709
105Aplasia/Hypoplasia of the uvula (HP:0010293)2.09546596
106Dysautonomia (HP:0002459)2.08976602
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08870980
108Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08870980
109Abnormality of the ileum (HP:0001549)2.07745029
110Skin pits (HP:0100276)2.07234786
111Gout (HP:0001997)2.06068433
112Vitreoretinal degeneration (HP:0000655)2.05895166
113Neurofibrillary tangles (HP:0002185)2.03459172
114Upper limb amyotrophy (HP:0009129)2.03449428
115Distal upper limb amyotrophy (HP:0007149)2.03449428
116Tubulointerstitial fibrosis (HP:0005576)2.02957707
117Abnormality of the labia minora (HP:0012880)2.02040356
118Action tremor (HP:0002345)2.00479646
119Ectopic kidney (HP:0000086)1.99977344
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99893474
121Ulnar bowing (HP:0003031)1.99379914
122Abnormal pancreas size (HP:0012094)1.99333722
123Hypoplasia of dental enamel (HP:0006297)1.96993377
124Aplasia/Hypoplasia of the earlobes (HP:0009906)1.95497429
125Nonprogressive disorder (HP:0003680)1.94681916
126Truncus arteriosus (HP:0001660)1.91362374
127Decreased circulating renin level (HP:0003351)1.90346237
128Acute encephalopathy (HP:0006846)1.90149555
129Resting tremor (HP:0002322)1.89210299
130Germ cell neoplasia (HP:0100728)1.88736005
131Respiratory distress (HP:0002098)1.86192368
132Supranuclear gaze palsy (HP:0000605)1.83764907
133Abnormality of renal excretion (HP:0011036)1.83374945
134Macrocytic anemia (HP:0001972)1.82845794
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80673845
136Abnormal protein N-linked glycosylation (HP:0012347)1.80673845
137Abnormal protein glycosylation (HP:0012346)1.80673845
138Abnormal glycosylation (HP:0012345)1.80673845
139Shoulder girdle muscle weakness (HP:0003547)1.80170829
140Anophthalmia (HP:0000528)1.79756055
141Retinitis pigmentosa (HP:0000510)1.78517344
142Malnutrition (HP:0004395)1.77935491
143Annular pancreas (HP:0001734)1.77765378
144Truncal ataxia (HP:0002078)1.77038147
145Reticulocytopenia (HP:0001896)1.76829806
146Cardiomegaly (HP:0001640)1.75946827
147Tubular atrophy (HP:0000092)1.75354448
148Progressive macrocephaly (HP:0004481)1.74619676
149Tarsal synostosis (HP:0008368)1.74561449
150Spinal muscular atrophy (HP:0007269)1.74521351
151Hypoplasia of the radius (HP:0002984)1.74093653
152Increased cerebral lipofuscin (HP:0011813)1.72967071
153Neoplasm of the heart (HP:0100544)1.72466715
154Short nail (HP:0001799)1.72441616
155Urinary urgency (HP:0000012)1.71964755
156Renal dysplasia (HP:0000110)1.71574390
157Capillary hemangiomas (HP:0005306)1.70653528
158Retinal dysplasia (HP:0007973)1.70290951
159Complement deficiency (HP:0004431)1.69975996
160Transposition of the great arteries (HP:0001669)1.69810773
161Abnormal connection of the cardiac segments (HP:0011545)1.69810773
162Abnormal ventriculo-arterial connection (HP:0011563)1.69810773
163Duodenal stenosis (HP:0100867)1.68982970
164Small intestinal stenosis (HP:0012848)1.68982970
165Partial duplication of thumb phalanx (HP:0009944)1.68434269
166Gait imbalance (HP:0002141)1.68022286
167Truncal obesity (HP:0001956)1.67755720
168Anxiety (HP:0000739)1.67012514
169Spontaneous abortion (HP:0005268)1.66802719
170Horizontal nystagmus (HP:0000666)1.66516604
171Pancreatic cysts (HP:0001737)1.65822736
172Increased muscle lipid content (HP:0009058)1.64892528
173Aplasia involving bones of the upper limbs (HP:0009823)1.64745900
174Aplasia of the phalanges of the hand (HP:0009802)1.64745900
175Aplasia involving bones of the extremities (HP:0009825)1.64745900
176Paraplegia (HP:0010550)1.64498841
177Increased neuronal autofluorescent lipopigment (HP:0002074)1.64009478
178Triphalangeal thumb (HP:0001199)1.63900841
179Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63605733
180Abnormality of alanine metabolism (HP:0010916)1.63605733
181Hyperalaninemia (HP:0003348)1.63605733
182Neoplasm of the adrenal cortex (HP:0100641)1.63446856
183Medial flaring of the eyebrow (HP:0010747)1.63380609
184Oligodactyly (HP:0012165)1.63316603
185Preaxial hand polydactyly (HP:0001177)1.61923594
186True hermaphroditism (HP:0010459)1.61373006
187Synostosis involving bones of the lower limbs (HP:0009138)1.59208752
188Synostosis involving bones of the feet (HP:0009140)1.59208752
189Opisthotonus (HP:0002179)1.58752309
190Facial diplegia (HP:0001349)1.57714664
191Cerebral inclusion bodies (HP:0100314)1.54663864
192Abnormal autonomic nervous system physiology (HP:0012332)1.53345402
193Menorrhagia (HP:0000132)1.53338040
194Stroke (HP:0001297)1.50957523
195Ankle contracture (HP:0006466)1.50886143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK17.66829549
2GRK15.43435962
3STK395.13448501
4PNCK4.24822579
5WNK43.71927215
6MST43.37861720
7ARAF2.90934617
8FGFR22.88827439
9TGFBR22.62932930
10MARK32.60586997
11CAMKK12.34587152
12LRRK22.28308288
13RIPK12.24156023
14BRAF2.10440762
15PRKD32.01187518
16MYLK1.97449469
17STK161.92820927
18ZAK1.87652570
19PTK61.82828878
20CAMKK21.79053803
21EPHB11.76062512
22VRK11.76024138
23WNK11.73035829
24INSRR1.64459897
25MAP3K91.61669454
26PDK21.56066427
27CASK1.52618550
28PHKG21.50094294
29PHKG11.50094294
30STK101.49692804
31TLK11.45892994
32MAP3K131.41882053
33MAP3K61.41146863
34CAMK1G1.37114004
35CDK191.34595094
36PBK1.30731728
37LIMK11.30513833
38MAP2K71.29956909
39NEK11.27588251
40TESK11.27327426
41LATS21.22227542
42LMTK21.21660082
43TRIB31.21529352
44PKN21.20345384
45CSNK1G31.15872354
46STK38L1.15030842
47DYRK21.13331184
48ERN11.13080456
49CAMK1D1.13014718
50FER1.11159137
51CDK31.09414991
52EPHA31.09112848
53FGFR31.09101802
54TTK1.06998054
55MOS1.05921864
56LATS11.05125716
57MAPK151.04618960
58PDGFRB1.04345953
59CSNK1A1L1.03347145
60ICK1.03224952
61TESK21.01419205
62JAK21.00515197
63SRPK11.00324521
64TTN0.99181486
65RET0.98482791
66OBSCN0.96807073
67MAPKAPK50.94313502
68CSNK1G10.92803959
69AKT30.91952247
70MAP3K70.88877021
71PRKCQ0.87856231
72FGFR10.86805335
73PAK40.86694145
74PRKAA20.86102708
75ROCK20.85460351
76WEE10.85069483
77CDC42BPA0.85029080
78PRKCZ0.83705837
79MAP3K40.82327870
80PRKCI0.81476221
81PLK40.78410357
82CAMK40.77500498
83AURKA0.77282668
84DYRK30.76479449
85MST1R0.75820664
86PRKCH0.74078875
87TAOK10.72441008
88STK240.72351590
89KSR20.71367794
90NEK20.70988432
91VRK20.70342980
92MAP3K50.69803836
93MAPK130.69674785
94SIK10.68962093
95MAP2K40.68913879
96PTK2B0.68081492
97MET0.67849260
98ERBB20.67051791
99ZAP700.66986667
100ROCK10.64744750
101FGFR40.63022807
102DYRK1B0.62876199
103JAK10.62220135
104WNK30.61849184
105PDGFRA0.61831985
106CAMK10.61663508
107CDK140.61330778
108BRSK10.60817631
109RPS6KA50.60569442
110SGK2230.59057166
111SGK4940.59057166
112TRPM70.57988654
113PLK10.57757622
114TAOK30.57080254
115PDK10.56717556
116CDK50.56691363
117OXSR10.56674415
118MAP3K20.56418568
119MARK10.55220073
120EPHB20.54409933
121PDPK10.53644650
122GSK3A0.51867193
123NME20.51680629
124PAK20.51472642
125PRKD10.51210474
126SRC0.50463118
127KSR10.50326016
128ALK0.50188188
129EEF2K0.50084484
130PIK3CG0.49363118
131BMPR1B0.47917090
132PTK20.46192946
133BUB10.46139571
134MAPK120.46022123
135STK380.43891658
136NTRK10.43349091
137PLK30.43212167
138IRAK20.41885055
139CHEK20.41879249
140SGK30.41367551
141STK110.40617767
142MAP4K20.40110594
143TIE10.40090592
144PRKACA0.39769019
145ADRBK10.39743266
146HIPK20.37983918
147PRKCA0.37800680
148MINK10.37229727
149PAK60.36701965
150DAPK20.36575866
151PAK10.35187829
152CDK11A0.35177202
153MELK0.34973742
154AKT20.34746726
155FES0.34586378
156DYRK1A0.34552258
157ILK0.34164520
158ATM0.33701860
159DMPK0.32881922
160PRKCE0.32554490
161SGK10.32282497
162DDR20.31469193
163SGK20.31071843
164ITK0.30787685
165CSNK1G20.30475128
166GRK50.29244338
167CDK90.28789631
168ABL20.28299512
169PKN10.28059995
170RPS6KB10.27748237
171CDK70.27377999
172NEK60.25820459
173MAP3K10.25645914
174CSNK1E0.25157531
175CDK150.24521968
176PRKAA10.22542737

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.87208354
2Sulfur relay system_Homo sapiens_hsa041224.01960843
3Nitrogen metabolism_Homo sapiens_hsa009102.86493922
4DNA replication_Homo sapiens_hsa030302.71566076
5Parkinsons disease_Homo sapiens_hsa050122.55523324
6Mineral absorption_Homo sapiens_hsa049782.41656818
7Mismatch repair_Homo sapiens_hsa034302.40499686
8Ribosome_Homo sapiens_hsa030102.37640796
9Nucleotide excision repair_Homo sapiens_hsa034202.33734194
10Fanconi anemia pathway_Homo sapiens_hsa034602.18193011
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04697210
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96162484
13Pyruvate metabolism_Homo sapiens_hsa006201.94310588
14Huntingtons disease_Homo sapiens_hsa050161.78776119
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71182081
16Basal transcription factors_Homo sapiens_hsa030221.68552540
17Lysosome_Homo sapiens_hsa041421.67304719
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.67050151
19Synaptic vesicle cycle_Homo sapiens_hsa047211.65022931
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65007896
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63262690
22Fatty acid biosynthesis_Homo sapiens_hsa000611.62134075
23Base excision repair_Homo sapiens_hsa034101.56478601
24Proteasome_Homo sapiens_hsa030501.56341255
25Pyrimidine metabolism_Homo sapiens_hsa002401.51365874
26Collecting duct acid secretion_Homo sapiens_hsa049661.47866604
27* Gastric acid secretion_Homo sapiens_hsa049711.47151384
28Homologous recombination_Homo sapiens_hsa034401.46921206
29Oocyte meiosis_Homo sapiens_hsa041141.46569784
30RNA polymerase_Homo sapiens_hsa030201.45540315
31Cell cycle_Homo sapiens_hsa041101.44672560
32RNA degradation_Homo sapiens_hsa030181.42692432
33Bile secretion_Homo sapiens_hsa049761.42155891
34Retinol metabolism_Homo sapiens_hsa008301.41331963
35RNA transport_Homo sapiens_hsa030131.34945908
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33887042
37GABAergic synapse_Homo sapiens_hsa047271.32629287
38Salivary secretion_Homo sapiens_hsa049701.32078117
39Protein digestion and absorption_Homo sapiens_hsa049741.30425743
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28713128
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27823885
42Protein export_Homo sapiens_hsa030601.24262520
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23420360
44Ether lipid metabolism_Homo sapiens_hsa005651.18219819
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18058967
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.17835712
47Alzheimers disease_Homo sapiens_hsa050101.16765895
48Olfactory transduction_Homo sapiens_hsa047401.14622809
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13733950
50Sulfur metabolism_Homo sapiens_hsa009201.13714699
51mTOR signaling pathway_Homo sapiens_hsa041501.13652461
52Propanoate metabolism_Homo sapiens_hsa006401.13572883
53Dilated cardiomyopathy_Homo sapiens_hsa054141.11583219
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09720236
55Circadian entrainment_Homo sapiens_hsa047131.08788324
56Hedgehog signaling pathway_Homo sapiens_hsa043401.08293223
57Thyroid hormone synthesis_Homo sapiens_hsa049181.07476388
58Glycerolipid metabolism_Homo sapiens_hsa005611.05682315
59Fatty acid elongation_Homo sapiens_hsa000621.05129277
60Starch and sucrose metabolism_Homo sapiens_hsa005001.04025085
61Vitamin digestion and absorption_Homo sapiens_hsa049771.02445054
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01586368
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01073276
64Folate biosynthesis_Homo sapiens_hsa007901.00168756
65mRNA surveillance pathway_Homo sapiens_hsa030150.98691883
66Fat digestion and absorption_Homo sapiens_hsa049750.97788396
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97289272
68Purine metabolism_Homo sapiens_hsa002300.96512584
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95715144
70ECM-receptor interaction_Homo sapiens_hsa045120.91543441
71Inositol phosphate metabolism_Homo sapiens_hsa005620.90542724
72Histidine metabolism_Homo sapiens_hsa003400.90093096
73Vibrio cholerae infection_Homo sapiens_hsa051100.88857811
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87573917
75Rheumatoid arthritis_Homo sapiens_hsa053230.87206196
76Renal cell carcinoma_Homo sapiens_hsa052110.87076922
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86435766
78Renin secretion_Homo sapiens_hsa049240.84949440
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83063742
80Complement and coagulation cascades_Homo sapiens_hsa046100.82839489
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80900829
82Dorso-ventral axis formation_Homo sapiens_hsa043200.79819094
83Phagosome_Homo sapiens_hsa041450.79524920
84Glutamatergic synapse_Homo sapiens_hsa047240.79350499
85Non-homologous end-joining_Homo sapiens_hsa034500.79179900
86Butanoate metabolism_Homo sapiens_hsa006500.78901747
87Insulin secretion_Homo sapiens_hsa049110.77689304
88Amphetamine addiction_Homo sapiens_hsa050310.73130550
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72647190
90Glutathione metabolism_Homo sapiens_hsa004800.72358519
91ABC transporters_Homo sapiens_hsa020100.71470620
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71365867
93Cardiac muscle contraction_Homo sapiens_hsa042600.71262800
94Cholinergic synapse_Homo sapiens_hsa047250.70017629
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69875942
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.69486907
97Arginine and proline metabolism_Homo sapiens_hsa003300.67466958
98Metabolic pathways_Homo sapiens_hsa011000.67302144
99Pentose phosphate pathway_Homo sapiens_hsa000300.67117288
100Oxytocin signaling pathway_Homo sapiens_hsa049210.66653225
101Morphine addiction_Homo sapiens_hsa050320.65383081
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64989233
103Amoebiasis_Homo sapiens_hsa051460.64893661
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64564854
105Phenylalanine metabolism_Homo sapiens_hsa003600.61643383
106Serotonergic synapse_Homo sapiens_hsa047260.61618028
107Fatty acid metabolism_Homo sapiens_hsa012120.60486157
108Cocaine addiction_Homo sapiens_hsa050300.58826623
109cAMP signaling pathway_Homo sapiens_hsa040240.58739798
110Focal adhesion_Homo sapiens_hsa045100.58175201
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.57401233
112Proteoglycans in cancer_Homo sapiens_hsa052050.56942629
113Selenocompound metabolism_Homo sapiens_hsa004500.56821314
114Other glycan degradation_Homo sapiens_hsa005110.56139709
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55652136
116Dopaminergic synapse_Homo sapiens_hsa047280.55571904
117Regulation of autophagy_Homo sapiens_hsa041400.54990797
118Nicotine addiction_Homo sapiens_hsa050330.54893917
119Fatty acid degradation_Homo sapiens_hsa000710.54396273
120Tyrosine metabolism_Homo sapiens_hsa003500.53460106
121Basal cell carcinoma_Homo sapiens_hsa052170.53435981
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53379019
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52896252
124Gap junction_Homo sapiens_hsa045400.52737744
125Tight junction_Homo sapiens_hsa045300.52412426
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52270755
127Ovarian steroidogenesis_Homo sapiens_hsa049130.52165295
128Pancreatic secretion_Homo sapiens_hsa049720.52083141
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52043281
130Arachidonic acid metabolism_Homo sapiens_hsa005900.50215521
131Endocytosis_Homo sapiens_hsa041440.48267280
132Circadian rhythm_Homo sapiens_hsa047100.47172009
133GnRH signaling pathway_Homo sapiens_hsa049120.46705694
134beta-Alanine metabolism_Homo sapiens_hsa004100.45166945
135Tuberculosis_Homo sapiens_hsa051520.45113904
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45030096
137Pancreatic cancer_Homo sapiens_hsa052120.44938314
138Hippo signaling pathway_Homo sapiens_hsa043900.44735646
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44666077
140Glioma_Homo sapiens_hsa052140.44432493
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.44133059
142Alcoholism_Homo sapiens_hsa050340.44089162
143Endometrial cancer_Homo sapiens_hsa052130.43812059
144Spliceosome_Homo sapiens_hsa030400.43075506
145Staphylococcus aureus infection_Homo sapiens_hsa051500.41990995
146Apoptosis_Homo sapiens_hsa042100.41929623
147Long-term potentiation_Homo sapiens_hsa047200.41845016
148Calcium signaling pathway_Homo sapiens_hsa040200.41826980
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.41655067
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38998291
151Axon guidance_Homo sapiens_hsa043600.38568047
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38527637
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.37706591
154Adherens junction_Homo sapiens_hsa045200.37163636
155Glucagon signaling pathway_Homo sapiens_hsa049220.36963970
156AMPK signaling pathway_Homo sapiens_hsa041520.36899078
157Steroid biosynthesis_Homo sapiens_hsa001000.36745976
158Notch signaling pathway_Homo sapiens_hsa043300.36571879
159Oxidative phosphorylation_Homo sapiens_hsa001900.35905098
160TGF-beta signaling pathway_Homo sapiens_hsa043500.35886045
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35615719
162Peroxisome_Homo sapiens_hsa041460.32989336
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.32780117
164Carbon metabolism_Homo sapiens_hsa012000.30855772
165Steroid hormone biosynthesis_Homo sapiens_hsa001400.30211518
166Long-term depression_Homo sapiens_hsa047300.29288045
167PPAR signaling pathway_Homo sapiens_hsa033200.28792537
168Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28179131
169Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28103535
170Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27772916
171p53 signaling pathway_Homo sapiens_hsa041150.26681481

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