KCNE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)8.74248862
2cell wall macromolecule catabolic process (GO:0016998)8.74248862
3ribosomal small subunit assembly (GO:0000028)7.92043589
4regulation of respiratory burst (GO:0060263)7.78355143
5viral transcription (GO:0019083)7.20994022
6translational termination (GO:0006415)7.00107932
7ribosomal large subunit biogenesis (GO:0042273)6.63545535
8fusion of sperm to egg plasma membrane (GO:0007342)6.55057039
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.13522591
10maturation of SSU-rRNA (GO:0030490)6.09018713
11translational elongation (GO:0006414)5.82499103
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.82425799
13positive regulation by organism of defense response of other organism involved in symbiotic interact5.82425799
14modulation by symbiont of host immune response (GO:0052553)5.82425799
15positive regulation by symbiont of host defense response (GO:0052509)5.82425799
16modulation by symbiont of host defense response (GO:0052031)5.82425799
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.82425799
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.81446647
19negative regulation of cell killing (GO:0031342)5.81446647
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.70474297
21cellular protein complex disassembly (GO:0043624)5.61177900
22positive regulation of gamma-delta T cell activation (GO:0046645)5.58010880
23cotranslational protein targeting to membrane (GO:0006613)5.57842862
24protein targeting to ER (GO:0045047)5.57511304
25ribosomal small subunit biogenesis (GO:0042274)5.54335363
26neutrophil activation involved in immune response (GO:0002283)5.43772863
27cytidine deamination (GO:0009972)5.41615056
28cytidine metabolic process (GO:0046087)5.41615056
29cytidine catabolic process (GO:0006216)5.41615056
30viral life cycle (GO:0019058)5.38843356
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.36114577
32establishment of protein localization to endoplasmic reticulum (GO:0072599)5.30007662
33detection of other organism (GO:0098543)5.20945331
34protein localization to endoplasmic reticulum (GO:0070972)5.18660997
35antigen processing and presentation of endogenous antigen (GO:0019883)5.16174472
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11719406
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.10032422
38negative regulation of glial cell proliferation (GO:0060253)5.04953351
39multicellular organism reproduction (GO:0032504)4.98667825
40regulation of hydrogen peroxide metabolic process (GO:0010310)4.98580415
41macrophage activation involved in immune response (GO:0002281)4.91996663
42sperm capacitation (GO:0048240)4.85010961
43detection of bacterium (GO:0016045)4.83811834
44translational initiation (GO:0006413)4.83800256
45protein complex disassembly (GO:0043241)4.80985305
46plasma membrane fusion (GO:0045026)4.80920573
47cilium or flagellum-dependent cell motility (GO:0001539)4.77958837
48response to peptidoglycan (GO:0032494)4.76750348
49detection of molecule of bacterial origin (GO:0032490)4.75935927
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63994038
51detection of external biotic stimulus (GO:0098581)4.62860756
52sperm-egg recognition (GO:0035036)4.62400862
53energy coupled proton transport, down electrochemical gradient (GO:0015985)4.59074108
54ATP synthesis coupled proton transport (GO:0015986)4.59074108
55acrosome assembly (GO:0001675)4.57597239
56macromolecular complex disassembly (GO:0032984)4.55795592
57pyrimidine ribonucleoside catabolic process (GO:0046133)4.53621070
58positive regulation of respiratory burst (GO:0060267)4.49396287
59glycerol ether metabolic process (GO:0006662)4.47335483
60negative regulation of interleukin-12 production (GO:0032695)4.44289441
61regulation of B cell receptor signaling pathway (GO:0050855)4.42676366
62respiratory electron transport chain (GO:0022904)4.42182487
63microglial cell activation (GO:0001774)4.41586347
64sperm motility (GO:0030317)4.39176501
65motile cilium assembly (GO:0044458)4.38866285
66electron transport chain (GO:0022900)4.32825292
67neutrophil activation (GO:0042119)4.26389894
68positive regulation of chemokine secretion (GO:0090197)4.23474407
69membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.23362278
70respiratory burst (GO:0045730)4.21629491
71positive regulation of digestive system process (GO:0060456)4.20687216
72regulation of chemokine secretion (GO:0090196)4.18919969
73reproduction (GO:0000003)4.18796377
74regulation of gamma-delta T cell activation (GO:0046643)4.15174678
75epithelial cilium movement (GO:0003351)4.13053691
76cell-cell recognition (GO:0009988)4.11967961
77ether metabolic process (GO:0018904)4.11799627
78regulation of interferon-beta biosynthetic process (GO:0045357)4.09748549
79detection of biotic stimulus (GO:0009595)4.07962993
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05816969
81positive regulation of mast cell activation (GO:0033005)4.05596631
82leukocyte migration involved in inflammatory response (GO:0002523)4.04442284
83negative regulation of lymphocyte mediated immunity (GO:0002707)4.02345872
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95851799
85regulation of mast cell degranulation (GO:0043304)3.95682797
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.94260540
87response to host immune response (GO:0052572)3.94260540
88cardiovascular system development (GO:0072358)3.93700973
89macrophage activation (GO:0042116)3.92364676
90immunoglobulin mediated immune response (GO:0016064)3.91262956
91granulocyte activation (GO:0036230)3.85135918
92ether lipid metabolic process (GO:0046485)3.82829994
93proline biosynthetic process (GO:0006561)3.82630244
94spermatid development (GO:0007286)3.79983698
95acrosome reaction (GO:0007340)3.77617928
96binding of sperm to zona pellucida (GO:0007339)3.75572132
97cellular extravasation (GO:0045123)3.75542113
98regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.73750780
99membrane repolarization during action potential (GO:0086011)3.73389515
100intestinal epithelial cell development (GO:0060576)3.72142225
101regulation of mast cell activation (GO:0033003)3.72072590
102leukocyte aggregation (GO:0070486)3.70306806
103regulation of mast cell activation involved in immune response (GO:0033006)3.69879921
104intestinal absorption (GO:0050892)3.68297006
105regulation of gamma-delta T cell differentiation (GO:0045586)3.65875282
106axonemal dynein complex assembly (GO:0070286)3.65875083
107protein targeting to membrane (GO:0006612)3.64596771
108negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.64248928
109regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.63374068
110regulation of myeloid leukocyte mediated immunity (GO:0002886)3.62943531
111myeloid cell activation involved in immune response (GO:0002275)3.62268612
112neutrophil mediated immunity (GO:0002446)3.60482822
113regulation of metalloenzyme activity (GO:0048552)3.58432323
114translation (GO:0006412)3.57054630
115regulation of cellular extravasation (GO:0002691)3.56653698
116positive regulation of mast cell degranulation (GO:0043306)3.56010101
117positive regulation of mast cell activation involved in immune response (GO:0033008)3.56010101
118response to host (GO:0075136)3.53371011
119response to host defenses (GO:0052200)3.53371011
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.53371011
121positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52221100
122negative regulation of leukocyte mediated immunity (GO:0002704)3.52167625
123antibacterial humoral response (GO:0019731)3.52094918
124flavonoid metabolic process (GO:0009812)3.49269497
125production of molecular mediator involved in inflammatory response (GO:0002532)3.46936338
126regulation of cilium movement (GO:0003352)3.45857979
127sulfation (GO:0051923)3.44595330
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.44370169
129potassium ion export (GO:0071435)3.43599443
130regulation of leukocyte degranulation (GO:0043300)3.43480614
131regulation of tolerance induction (GO:0002643)3.41628260
132antigen processing and presentation via MHC class Ib (GO:0002475)3.41277675
133transepithelial transport (GO:0070633)3.39775708
134response to interleukin-15 (GO:0070672)3.39558410
135nuclear-transcribed mRNA catabolic process (GO:0000956)3.37567337
136antimicrobial humoral response (GO:0019730)3.36943907
137cilium movement (GO:0003341)3.36240551
138bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33105431
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.32943442
140dendritic cell migration (GO:0036336)3.30881117
141regulation of vitamin metabolic process (GO:0030656)3.30854908
142ATP biosynthetic process (GO:0006754)3.27765148
143purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.26394464
144negative regulation of T cell mediated immunity (GO:0002710)3.26264482
145negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22824599
146GTP biosynthetic process (GO:0006183)3.21597072
147atrial cardiac muscle cell action potential (GO:0086014)3.21397769
148negative regulation of epidermal cell differentiation (GO:0045605)3.21375646
149regulation of mitochondrial translation (GO:0070129)3.21222392
150purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19858820
151positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.18430998
152ribonucleoprotein complex biogenesis (GO:0022613)3.18314225
153dendritic cell chemotaxis (GO:0002407)3.17901475
154mRNA catabolic process (GO:0006402)3.15806488
155B cell receptor signaling pathway (GO:0050853)3.14386365
156superoxide anion generation (GO:0042554)3.13323389
157single fertilization (GO:0007338)3.13033826
158positive regulation of cellular amide metabolic process (GO:0034250)3.12256085
159cellular response to interleukin-15 (GO:0071350)3.12025226
160myeloid leukocyte mediated immunity (GO:0002444)3.10095470
161diol metabolic process (GO:0034311)3.09156357
162interferon-gamma-mediated signaling pathway (GO:0060333)3.08667082
163B cell mediated immunity (GO:0019724)3.05308378
164regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04127460
165hydrogen ion transmembrane transport (GO:1902600)3.02587954
166nucleoside salvage (GO:0043174)3.02541761
167leukocyte degranulation (GO:0043299)3.01622995
168regulation of regulated secretory pathway (GO:1903305)3.00831341
169regulation of T cell tolerance induction (GO:0002664)3.00635622
170positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00456472
171cell differentiation involved in embryonic placenta development (GO:0060706)2.99382027
172positive regulation of B cell differentiation (GO:0045579)2.97149976
173regulation of glial cell proliferation (GO:0060251)2.96093863
174UTP metabolic process (GO:0046051)2.96073428
175regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95396537
176regulation of T cell mediated cytotoxicity (GO:0001914)2.93402702
177chromosome condensation (GO:0030261)2.93235507
178chromatin remodeling at centromere (GO:0031055)2.92610338
179defense response to protozoan (GO:0042832)2.91253513
180negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90929345
181response to type I interferon (GO:0034340)2.90283512
182tolerance induction (GO:0002507)2.90194909
183cellular response to type I interferon (GO:0071357)2.89533935
184type I interferon signaling pathway (GO:0060337)2.89533935
185negative regulation of interleukin-6 production (GO:0032715)2.89518710
186regulation of B cell differentiation (GO:0045577)2.89431863
187positive regulation of tolerance induction (GO:0002645)2.87703586
188positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86872310
189positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84713195
190regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.84668909
191neutrophil chemotaxis (GO:0030593)2.83899661
192activated T cell proliferation (GO:0050798)2.83884465
193regulation of regulatory T cell differentiation (GO:0045589)2.83760675
194regulation of interleukin-6 biosynthetic process (GO:0045408)2.83625970
195hydrogen peroxide biosynthetic process (GO:0050665)2.83271562
196response to muramyl dipeptide (GO:0032495)2.82852225
197myeloid leukocyte activation (GO:0002274)2.81587878
198germinal center formation (GO:0002467)2.80230021
199regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79788155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.83997402
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.56713453
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.54511799
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.46683491
5E2F7_22180533_ChIP-Seq_HELA_Human4.23613414
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.78178363
7CDX2_20551321_ChIP-Seq_CACO-2_Human3.71770553
8EZH2_22144423_ChIP-Seq_EOC_Human3.62214899
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50277146
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.48623651
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48289641
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.43407534
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.41543393
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26753959
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21747325
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10362272
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.95355633
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.93601533
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76370097
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69615600
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63002836
22SPI1_23127762_ChIP-Seq_K562_Human2.60940680
23SPI1_23547873_ChIP-Seq_NB4_Human2.59910975
24SOX2_27498859_Chip-Seq_STOMACH_Mouse2.59845062
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59808966
26RUNX_20019798_ChIP-Seq_JUKART_Human2.53777780
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52391670
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52353380
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49815750
30AR_21909140_ChIP-Seq_LNCAP_Human2.47825091
31VDR_24763502_ChIP-Seq_THP-1_Human2.39514375
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38057428
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.37899860
34SCL_19346495_ChIP-Seq_HPC-7_Human2.35555624
35* GATA4_25053715_ChIP-Seq_YYC3_Human2.34267077
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30101600
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29683722
38VDR_24787735_ChIP-Seq_THP-1_Human2.12672215
39MYB_26560356_Chip-Seq_TH2_Human2.03038974
40* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00759629
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99963023
42KAP1_22055183_ChIP-Seq_ESCs_Mouse1.99937584
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.98566931
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98269188
45* GATA6_25053715_ChIP-Seq_YYC3_Human1.95403787
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93415304
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91911140
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91746991
49VDR_21846776_ChIP-Seq_THP-1_Human1.89036334
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87474568
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86199222
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85579161
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.83978380
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83866519
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82207346
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82163782
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79016638
58MAF_26560356_Chip-Seq_TH1_Human1.75317254
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74524115
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74254136
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70232331
62XRN2_22483619_ChIP-Seq_HELA_Human1.70186773
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68774308
64MYB_26560356_Chip-Seq_TH1_Human1.66291547
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65220748
66GATA3_27048872_Chip-Seq_THYMUS_Human1.65121715
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65107963
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62573116
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60028291
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59717301
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.59637488
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58539255
73UTX_26944678_Chip-Seq_JUKART_Human1.55461542
74DCP1A_22483619_ChIP-Seq_HELA_Human1.55389990
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53853873
76* SOX2_20726797_ChIP-Seq_SW620_Human1.53399045
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.52730518
78* GATA1_19941827_ChIP-Seq_MEL_Mouse1.52478606
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51679750
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51532631
81GATA3_26560356_Chip-Seq_TH2_Human1.47778706
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.46944000
83GATA1_19941826_ChIP-Seq_K562_Human1.45250732
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45057667
85GATA1_22025678_ChIP-Seq_K562_Human1.44582556
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43591712
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42229826
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41383513
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.39994706
90* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39107879
91* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38511598
92EST1_17652178_ChIP-ChIP_JURKAT_Human1.37396757
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36919157
94TTF2_22483619_ChIP-Seq_HELA_Human1.35464410
95NANOG_20526341_ChIP-Seq_ESCs_Human1.33858429
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33715376
97MYC_18940864_ChIP-ChIP_HL60_Human1.30859020
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29276760
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28734615
100PU_27001747_Chip-Seq_BMDM_Mouse1.27045309
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25985559
102TCF7_22412390_ChIP-Seq_EML_Mouse1.24496880
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23807733
104GATA2_19941826_ChIP-Seq_K562_Human1.23318997
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22349086
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22184076
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22145571
108GATA3_21867929_ChIP-Seq_CD8_Mouse1.21649771
109* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20206303
110GATA2_21666600_ChIP-Seq_HMVEC_Human1.19524799
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18672031
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18564704
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17340455
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17183882
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16588478
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16220777
117CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15608931
118* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14029645
119MAF_26560356_Chip-Seq_TH2_Human1.11368298
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10213200
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08814373
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05231953
123GABP_17652178_ChIP-ChIP_JURKAT_Human1.04999813
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.04548962
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04445738
126OCT4_18555785_Chip-Seq_ESCs_Mouse1.03616704
127* STAT1_17558387_ChIP-Seq_HELA_Human1.03340234
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.02608986
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02597305
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02553326
131MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02365815
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02344076
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.01598645
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99977170
135* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99763355
136P53_21459846_ChIP-Seq_SAOS-2_Human0.99429950
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99353470
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.99353470
139TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99231879
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98770099
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98387012
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98104420
143* SMRT_27268052_Chip-Seq_Bcells_Human0.98053640
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.97771591
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97509416
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96876739
147FOXP3_21729870_ChIP-Seq_TREG_Human0.95177866
148BCL6_27268052_Chip-Seq_Bcells_Human0.94913136
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94696898
150ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94237045
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94208143
152STAT1_20625510_ChIP-Seq_HELA_Human0.94006118
153KDM2B_26808549_Chip-Seq_DND41_Human0.93302308
154P53_22387025_ChIP-Seq_ESCs_Mouse0.92711770
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.91449851
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91221890
157ESRRB_18555785_Chip-Seq_ESCs_Mouse0.87876832
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87864483
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87485066
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.87432812
161P300_18555785_Chip-Seq_ESCs_Mouse0.86640678
162JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86491955
163SOX2_22085726_ChIP-Seq_NPCs_Mouse0.86469479
164CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85290094
165BCOR_27268052_Chip-Seq_Bcells_Human0.84690277
166KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83574396
167MYC_19829295_ChIP-Seq_ESCs_Human0.83255358
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81980542
169RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81965282
170ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81954369
171GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80412723
172KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79714596
173DROSHA_22980978_ChIP-Seq_HELA_Human0.79114597
174ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78831910
175SPI1_20517297_ChIP-Seq_HL60_Human0.78702849
176CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78422234
177CDX2_22108803_ChIP-Seq_LS180_Human0.78179023
178MYC_22102868_ChIP-Seq_BL_Human0.77690846
179GATA3_21878914_ChIP-Seq_MCF-7_Human0.77619490
180AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77543575
181LXR_22158963_ChIP-Seq_LIVER_Mouse0.77450843
182KLF4_18555785_Chip-Seq_ESCs_Mouse0.77381044
183FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77351851
184KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77187031
185NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77145933
186SOX2_18555785_Chip-Seq_ESCs_Mouse0.77119871
187SMAD1_18555785_Chip-Seq_ESCs_Mouse0.77101786
188PU1_27457419_Chip-Seq_LIVER_Mouse0.75167574
189PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74516550
190EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.74417855
191FOXO3_23340844_ChIP-Seq_DLD1_Human0.72984585
192RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71361398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.67318195
2MP0008004_abnormal_stomach_pH5.54867577
3MP0003724_increased_susceptibility_to5.23021385
4MP0005410_abnormal_fertilization4.32573889
5MP0003300_gastrointestinal_ulcer4.10256178
6MP0003787_abnormal_imprinting3.91964744
7MP0000462_abnormal_digestive_system3.89683929
8MP0003123_paternal_imprinting3.87443575
9MP0003436_decreased_susceptibility_to3.82983106
10MP0001835_abnormal_antigen_presentation3.68546742
11MP0003303_peritoneal_inflammation3.55666164
12MP0000490_abnormal_crypts_of3.22516995
13MP0002419_abnormal_innate_immunity3.08981319
14MP0001873_stomach_inflammation2.98557172
15MP0009785_altered_susceptibility_to2.92137750
16MP0005671_abnormal_response_to2.90861157
17MP0005025_abnormal_response_to2.84679551
18MP0003693_abnormal_embryo_hatching2.78933170
19MP0006082_CNS_inflammation2.77349963
20MP0001790_abnormal_immune_system2.75880215
21MP0005387_immune_system_phenotype2.75880215
22MP0001800_abnormal_humoral_immune2.71077728
23MP0000685_abnormal_immune_system2.60955472
24MP0005000_abnormal_immune_tolerance2.55837894
25MP0005085_abnormal_gallbladder_physiolo2.54707131
26MP0002148_abnormal_hypersensitivity_rea2.44670899
27MP0002723_abnormal_immune_serum2.43149457
28MP0002132_abnormal_respiratory_system2.43018496
29MP0002452_abnormal_antigen_presenting2.39152829
30* MP0001663_abnormal_digestive_system2.38967528
31MP0005360_urolithiasis2.34569937
32MP0002420_abnormal_adaptive_immunity2.33469643
33MP0005464_abnormal_platelet_physiology2.32268931
34* MP0010155_abnormal_intestine_physiology2.32217086
35MP0001819_abnormal_immune_cell2.31577154
36MP0002277_abnormal_respiratory_mucosa2.28012723
37MP0010234_abnormal_vibrissa_follicle2.23907815
38* MP0005381_digestive/alimentary_phenotyp2.19741556
39MP0002138_abnormal_hepatobiliary_system2.19061463
40MP0001533_abnormal_skeleton_physiology2.16734860
41MP0003866_abnormal_defecation2.14711858
42MP0003191_abnormal_cellular_cholesterol2.13289984
43MP0000537_abnormal_urethra_morphology2.12593873
44MP0004264_abnormal_extraembryonic_tissu2.07297919
45MP0002139_abnormal_hepatobiliary_system2.05946460
46MP0001664_abnormal_digestion2.05465408
47MP0001485_abnormal_pinna_reflex2.02825669
48MP0001666_abnormal_nutrient_absorption2.02794107
49MP0000566_synostosis2.02557087
50MP0003172_abnormal_lysosome_physiology1.95866032
51MP0000465_gastrointestinal_hemorrhage1.94648704
52MP0004957_abnormal_blastocyst_morpholog1.92875104
53MP0001845_abnormal_inflammatory_respons1.86541485
54MP0002405_respiratory_system_inflammati1.85149069
55MP0003828_pulmonary_edema1.83996353
56MP0003252_abnormal_bile_duct1.82493878
57MP0000477_abnormal_intestine_morphology1.76876913
58MP0004019_abnormal_vitamin_homeostasis1.72427456
59MP0009764_decreased_sensitivity_to1.70874605
60MP0000716_abnormal_immune_system1.68204579
61MP0008260_abnormal_autophagy1.67737122
62MP0005365_abnormal_bile_salt1.65669148
63MP0002398_abnormal_bone_marrow1.60331739
64MP0002163_abnormal_gland_morphology1.59316815
65MP0001929_abnormal_gametogenesis1.58304039
66MP0004883_abnormal_blood_vessel1.57000903
67MP0005310_abnormal_salivary_gland1.55946469
68MP0003698_abnormal_male_reproductive1.54643564
69MP0010352_gastrointestinal_tract_polyps1.53643878
70MP0008469_abnormal_protein_level1.51447589
71MP0003075_altered_response_to1.44422352
72MP0009278_abnormal_bone_marrow1.43383290
73MP0004947_skin_inflammation1.42670464
74MP0003763_abnormal_thymus_physiology1.42543023
75MP0003011_delayed_dark_adaptation1.42408542
76MP0005058_abnormal_lysosome_morphology1.41473017
77MP0000689_abnormal_spleen_morphology1.40353137
78MP0009333_abnormal_splenocyte_physiolog1.39787864
79MP0003315_abnormal_perineum_morphology1.37647942
80MP0000613_abnormal_salivary_gland1.37397803
81MP0002722_abnormal_immune_system1.35830881
82MP0001545_abnormal_hematopoietic_system1.32087691
83MP0005397_hematopoietic_system_phenotyp1.32087691
84MP0001348_abnormal_lacrimal_gland1.31985084
85MP0002429_abnormal_blood_cell1.31205009
86MP0005164_abnormal_response_to1.30106335
87MP0005451_abnormal_body_composition1.29251141
88MP0000470_abnormal_stomach_morphology1.27990123
89MP0002998_abnormal_bone_remodeling1.25666091
90MP0000858_altered_metastatic_potential1.21336219
91MP0000343_altered_response_to1.20871640
92MP0002928_abnormal_bile_duct1.17917364
93MP0002396_abnormal_hematopoietic_system1.14706239
94MP0000604_amyloidosis1.13228967
95MP0003690_abnormal_glial_cell1.12190073
96MP0003283_abnormal_digestive_organ1.07692035
97MP0003119_abnormal_digestive_system1.07305838
98MP0005174_abnormal_tail_pigmentation1.06051407
99MP0004381_abnormal_hair_follicle1.05670526
100MP0003656_abnormal_erythrocyte_physiolo1.05124764
101MP0000538_abnormal_urinary_bladder1.03499424
102MP0009697_abnormal_copulation1.03182599
103MP0001851_eye_inflammation1.01717830
104MP0000703_abnormal_thymus_morphology1.00615748
105MP0002210_abnormal_sex_determination1.00354995
106MP0005636_abnormal_mineral_homeostasis0.99954896
107MP0001765_abnormal_ion_homeostasis0.97203274
108MP0005083_abnormal_biliary_tract0.96906184
109MP0001986_abnormal_taste_sensitivity0.95785838
110MP0002009_preneoplasia0.92265736
111MP0001145_abnormal_male_reproductive0.92147750
112MP0002166_altered_tumor_susceptibility0.92019164
113MP0002098_abnormal_vibrissa_morphology0.90453751
114MP0010094_abnormal_chromosome_stability0.90249219
115MP0008877_abnormal_DNA_methylation0.89937667
116MP0002736_abnormal_nociception_after0.88346398
117MP0000653_abnormal_sex_gland0.87150783
118MP0003448_altered_tumor_morphology0.86740577
119MP0009763_increased_sensitivity_to0.86191942
120MP0003453_abnormal_keratinocyte_physiol0.84072624
121MP0000015_abnormal_ear_pigmentation0.83742013
122MP0008875_abnormal_xenobiotic_pharmacok0.83166329
123MP0003718_maternal_effect0.82575726
124MP0000569_abnormal_digit_pigmentation0.82544055
125MP0005390_skeleton_phenotype0.80954444
126MP0008932_abnormal_embryonic_tissue0.79935171
127MP0003111_abnormal_nucleus_morphology0.79062238
128MP0009840_abnormal_foam_cell0.78767839
129MP0009643_abnormal_urine_homeostasis0.78303960
130MP0001849_ear_inflammation0.78047114
131MP0002006_tumorigenesis0.77863331
132MP0000249_abnormal_blood_vessel0.77838990
133MP0005167_abnormal_blood-brain_barrier0.75409884
134MP0006054_spinal_hemorrhage0.75234962
135MP0002796_impaired_skin_barrier0.74906843
136MP0003077_abnormal_cell_cycle0.74740652
137MP0006036_abnormal_mitochondrial_physio0.73890006
138MP0004510_myositis0.73835950
139MP0005084_abnormal_gallbladder_morpholo0.73818453
140MP0010386_abnormal_urinary_bladder0.73434773
141MP0005220_abnormal_exocrine_pancreas0.73378814
142MP0005379_endocrine/exocrine_gland_phen0.71241802
143MP0003806_abnormal_nucleotide_metabolis0.70676218
144MP0003186_abnormal_redox_activity0.70612187
145MP0004484_altered_response_of0.70469063
146MP0001764_abnormal_homeostasis0.70360959
147MP0003045_fibrosis0.69628333
148MP0009765_abnormal_xenobiotic_induced0.68272639
149MP0001853_heart_inflammation0.67795788
150MP0004130_abnormal_muscle_cell0.67681472
151MP0003868_abnormal_feces_composition0.67401779
152MP0005075_abnormal_melanosome_morpholog0.65029094
153MP0003795_abnormal_bone_structure0.64989739
154MP0002161_abnormal_fertility/fecundity0.64095395
155MP0002254_reproductive_system_inflammat0.62002713
156MP0005166_decreased_susceptibility_to0.61347154
157MP0003121_genomic_imprinting0.61318418
158MP0002060_abnormal_skin_morphology0.59220332
159MP0005319_abnormal_enzyme/_coenzyme0.59082365
160MP0001756_abnormal_urination0.57542090
161* MP0008872_abnormal_physiological_respon0.56920366
162MP0000313_abnormal_cell_death0.56235499
163MP0008874_decreased_physiological_sensi0.56068991
164MP0005501_abnormal_skin_physiology0.55589455
165MP0001216_abnormal_epidermal_layer0.54921261
166MP0000579_abnormal_nail_morphology0.52842918
167MP0010771_integument_phenotype0.50508133
168MP0003183_abnormal_peptide_metabolism0.50327560
169MP0003137_abnormal_impulse_conducting0.50236315
170MP0005408_hypopigmentation0.50230412
171MP0001270_distended_abdomen0.48446347
172MP0001730_embryonic_growth_arrest0.47312921
173MP0000678_abnormal_parathyroid_gland0.45504825
174MP0000762_abnormal_tongue_morphology0.45079334

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.00586306
2Eczematoid dermatitis (HP:0000976)6.64374784
3Abnormal hemoglobin (HP:0011902)6.43279657
4Recurrent bacterial skin infections (HP:0005406)6.09769904
5Recurrent abscess formation (HP:0002722)6.05750653
6Myositis (HP:0100614)5.66274303
7Orchitis (HP:0100796)5.39257946
8Abnormality of macrophages (HP:0004311)5.31399207
9Optic neuritis (HP:0100653)5.14799821
10Retrobulbar optic neuritis (HP:0100654)5.14799821
11Congenital sensorineural hearing impairment (HP:0008527)5.05413307
12Recurrent gram-negative bacterial infections (HP:0005420)5.05277621
13Reticulocytopenia (HP:0001896)4.93521065
14Stomatitis (HP:0010280)4.91132140
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.71766997
16Elevated erythrocyte sedimentation rate (HP:0003565)4.46785302
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.41554172
18Absent/shortened dynein arms (HP:0200106)4.41554172
19Macrocytic anemia (HP:0001972)4.15638851
20Male infertility (HP:0003251)4.09496329
21Rectal prolapse (HP:0002035)4.09228618
22Recurrent fungal infections (HP:0002841)4.03930401
23Colon cancer (HP:0003003)4.03464202
24Abnormality of cells of the erythroid lineage (HP:0012130)4.03241899
25Obstructive lung disease (HP:0006536)4.00683743
26Chronic obstructive pulmonary disease (HP:0006510)4.00683743
27* Ventricular fibrillation (HP:0001663)3.99801944
28Recurrent skin infections (HP:0001581)3.99438834
29Aplasia/Hypoplasia of the sacrum (HP:0008517)3.98315284
30Increased hepatocellular lipid droplets (HP:0006565)3.95235947
31Gastrointestinal infarctions (HP:0005244)3.92520130
32Abnormal number of erythroid precursors (HP:0012131)3.86429320
33Decreased activity of mitochondrial respiratory chain (HP:0008972)3.84329968
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.84329968
35Mediastinal lymphadenopathy (HP:0100721)3.84019026
36Spontaneous hematomas (HP:0007420)3.80896540
37Keratoconjunctivitis sicca (HP:0001097)3.70791659
38Hepatic necrosis (HP:0002605)3.70646423
39Lipid accumulation in hepatocytes (HP:0006561)3.70567923
40Increased intramyocellular lipid droplets (HP:0012240)3.66581009
41Pallor (HP:0000980)3.64413154
42Hepatocellular necrosis (HP:0001404)3.63298654
43Meningitis (HP:0001287)3.59685569
44Prolonged bleeding time (HP:0003010)3.59592834
45Gingivitis (HP:0000230)3.56046053
46Encephalitis (HP:0002383)3.55949105
47Abnormal delayed hypersensitivity skin test (HP:0002963)3.52903600
48Chronic mucocutaneous candidiasis (HP:0002728)3.51154087
49Recurrent cutaneous fungal infections (HP:0011370)3.51154087
50Keratoconjunctivitis (HP:0001096)3.48434746
51Mitochondrial inheritance (HP:0001427)3.46292181
52Increased muscle lipid content (HP:0009058)3.43354996
53Trismus (HP:0000211)3.42402608
54Abnormal respiratory epithelium morphology (HP:0012253)3.29045602
55Abnormal respiratory motile cilium morphology (HP:0005938)3.29045602
56Vasculitis (HP:0002633)3.25097610
57Hemoptysis (HP:0002105)3.19876670
58Urticaria (HP:0001025)3.19343167
59Abnormal respiratory motile cilium physiology (HP:0012261)3.16481525
60Abnormality of renal resorption (HP:0011038)3.12484618
61Pustule (HP:0200039)3.07177710
6211 pairs of ribs (HP:0000878)3.04367856
63Renal Fanconi syndrome (HP:0001994)3.01178518
64Abnormal biliary tract morphology (HP:0012440)2.99821330
65Abnormality of placental membranes (HP:0011409)2.99745264
66Amniotic constriction ring (HP:0009775)2.99745264
67Gingival bleeding (HP:0000225)2.98166340
68Pulmonary infiltrates (HP:0002113)2.97498839
69Petechiae (HP:0000967)2.95610761
70Hypochromic microcytic anemia (HP:0004840)2.94643605
71Oral leukoplakia (HP:0002745)2.94127964
72Increased CSF lactate (HP:0002490)2.93800878
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.91279079
74Increased cerebral lipofuscin (HP:0011813)2.90743758
75Epistaxis (HP:0000421)2.89125240
76Glycosuria (HP:0003076)2.87932283
77Abnormality of urine glucose concentration (HP:0011016)2.87932283
78Chest pain (HP:0100749)2.87908406
79Abnormality of liposaccharide metabolism (HP:0010968)2.87602795
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.87602795
81Abnormality of glycolipid metabolism (HP:0010969)2.87602795
82Exertional dyspnea (HP:0002875)2.87375768
83Right ventricular cardiomyopathy (HP:0011663)2.84008294
84Arterial thrombosis (HP:0004420)2.82967892
85T lymphocytopenia (HP:0005403)2.79459936
86Biliary tract neoplasm (HP:0100574)2.79149157
87Episodic fever (HP:0001954)2.79018907
88Amyloidosis (HP:0011034)2.78534710
89Abnormality of T cell number (HP:0011839)2.75879144
90Poikiloderma (HP:0001029)2.74132899
91Abnormal spermatogenesis (HP:0008669)2.72765331
92Purpura (HP:0000979)2.71790505
93Ankyloglossia (HP:0010296)2.70265618
94Leukocytosis (HP:0001974)2.69618434
95Increased serum lactate (HP:0002151)2.67161316
96Pulmonary embolism (HP:0002204)2.67081288
97Abnormal mitochondria in muscle tissue (HP:0008316)2.65350720
98Hypochromic anemia (HP:0001931)2.62883343
99Cheilitis (HP:0100825)2.61674211
100Acute encephalopathy (HP:0006846)2.61554715
101Anorexia (HP:0002039)2.60242656
102Acute necrotizing encephalopathy (HP:0006965)2.58076638
103Increased IgE level (HP:0003212)2.55369331
104Cellulitis (HP:0100658)2.54621108
105Chronic otitis media (HP:0000389)2.53977382
106Inflammation of the large intestine (HP:0002037)2.53151482
107Increased neuronal autofluorescent lipopigment (HP:0002074)2.51401769
108Infertility (HP:0000789)2.50277306
109Abnormality of chloride homeostasis (HP:0011422)2.50225900
110Abnormal ciliary motility (HP:0012262)2.49284733
111Rhinitis (HP:0012384)2.49199166
112Prolonged QT interval (HP:0001657)2.48873351
113Chronic bronchitis (HP:0004469)2.47774481
114Syncope (HP:0001279)2.46318919
115Peritonitis (HP:0002586)2.45801685
116Systemic lupus erythematosus (HP:0002725)2.44183143
117Recurrent viral infections (HP:0004429)2.44022006
118Osteomyelitis (HP:0002754)2.40253467
119Abnormality of T cells (HP:0002843)2.38931071
120Thin bony cortex (HP:0002753)2.37167761
121Premature loss of primary teeth (HP:0006323)2.36463713
122Abnormality of the nasal mucosa (HP:0000433)2.36455711
123Gastrointestinal inflammation (HP:0004386)2.35756266
124Bronchiectasis (HP:0002110)2.35139331
125Ridged nail (HP:0001807)2.33855451
126Progressive macrocephaly (HP:0004481)2.32664411
127Fragile skin (HP:0001030)2.31509588
128Azoospermia (HP:0000027)2.30473667
129Gangrene (HP:0100758)2.30422509
130Recurrent sinusitis (HP:0011108)2.29912557
131Multiple enchondromatosis (HP:0005701)2.28194094
132Absent thumb (HP:0009777)2.26754460
133Pili torti (HP:0003777)2.25347899
134Abnormality of the pleura (HP:0002103)2.24917530
135Conjugated hyperbilirubinemia (HP:0002908)2.23444904
136Panhypogammaglobulinemia (HP:0003139)2.19325441
137Thrombocytosis (HP:0001894)2.19279513
138Microcytic anemia (HP:0001935)2.18953974
139Rough bone trabeculation (HP:0100670)2.17619747
140Malnutrition (HP:0004395)2.15636075
141Villous atrophy (HP:0011473)2.14151879
142Abnormality of small intestinal villus morphology (HP:0011472)2.14151879
143Vacuolated lymphocytes (HP:0001922)2.13834229
144Acne (HP:0001061)2.12673785
145Increased IgM level (HP:0003496)2.09370116
146Granulocytopenia (HP:0001913)2.09020957
147Abnormality of iron homeostasis (HP:0011031)2.08499620
148Posterior subcapsular cataract (HP:0007787)2.07700253
149Micronodular cirrhosis (HP:0001413)2.07648299
150Hyperphosphaturia (HP:0003109)2.07372617
151Abnormality of the right ventricle (HP:0001707)2.06974157
152Vertigo (HP:0002321)2.06686044
153Recurrent pneumonia (HP:0006532)2.05872517
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04103953
155Hematochezia (HP:0002573)2.04093998
156Colitis (HP:0002583)2.03625560
157Abnormal platelet volume (HP:0011876)2.02995910
158Abnormality of T cell physiology (HP:0011840)2.02597761
159Gastrointestinal dysmotility (HP:0002579)2.02415570
160Loss of speech (HP:0002371)2.02157955
161Increased serum ferritin (HP:0003281)2.02132000
162Xerostomia (HP:0000217)2.01244859
163Polyneuropathy (HP:0001271)1.98380935
164Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98347542
165Autoimmune thrombocytopenia (HP:0001973)1.97951861
166Abnormality of the endocardium (HP:0004306)1.97318428
167Abnormality of the preputium (HP:0100587)1.96858583
168Periodontitis (HP:0000704)1.96678820
169Dysostosis multiplex (HP:0000943)1.96511572
170Respiratory failure (HP:0002878)1.95652634
171Disinhibition (HP:0000734)1.95353148
172Recurrent bronchitis (HP:0002837)1.94490491
173Glomerulopathy (HP:0100820)1.93835456
174Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92612553
175Lactic acidosis (HP:0003128)1.92404969
176Nasal polyposis (HP:0100582)1.92367040
177Neoplasm of the colon (HP:0100273)1.92184734
178Exercise intolerance (HP:0003546)1.89918840
179Neoplasm of the rectum (HP:0100743)1.88828824
180Hepatosplenomegaly (HP:0001433)1.88650396
181Neoplasm of the small intestine (HP:0100833)1.87632699
182Pulmonary fibrosis (HP:0002206)1.86698810
183Delayed epiphyseal ossification (HP:0002663)1.84797773
184Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84097225
185Chorioretinal atrophy (HP:0000533)1.83006909
186Respiratory difficulties (HP:0002880)1.81005714
187Abdominal distention (HP:0003270)1.80705701
188Missing ribs (HP:0000921)1.80321201
189Cerebral edema (HP:0002181)1.80284225
190Enlarged epiphyses (HP:0010580)1.80093122
191Aplastic anemia (HP:0001915)1.79770352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK28.58282738
2RIPK45.31175583
3NME13.67891014
4PBK3.26075773
5EIF2AK13.18537238
6PDK43.09350833
7PDK33.09350833
8IRAK43.07536560
9MAP4K12.97393269
10TYK22.95802552
11CSK2.91439776
12FRK2.78189059
13STK392.77966244
14MAP2K32.68535521
15PRKG22.68465175
16TLK12.66449760
17FES2.50737201
18MAP2K62.38900400
19GRK62.36197337
20ZAP702.29226096
21NUAK12.27880768
22MST1R2.21993693
23FGR2.04327560
24MAP2K22.04022338
25MST41.99738704
26TTK1.96252754
27TXK1.92632672
28PRKD31.89898633
29TNK21.88449451
30EPHB11.86101804
31BTK1.84934355
32PDK21.78636281
33SYK1.75908136
34JAK31.73967629
35NME21.72320513
36IRAK31.70527067
37MAP3K31.64657175
38HCK1.64053499
39NEK21.59582442
40TESK11.57073906
41PKN21.55983085
42EPHB21.54023186
43LYN1.51854150
44MAP3K141.50846318
45TAOK11.49056746
46ACVR1B1.47359492
47JAK21.47022603
48CDK121.46579466
49IKBKE1.44027815
50YES11.43025284
51PRPF4B1.39804956
52KIT1.33586048
53JAK11.33491687
54RIPK11.31306924
55MAP3K11.29393332
56ERBB21.28989188
57CSF1R1.28705341
58WNK41.23800707
59AURKB1.18282757
60KSR21.13249953
61TGFBR21.12754178
62LCK1.11990825
63BMPR21.10281111
64CDK191.09916033
65ITK1.08648346
66OXSR11.07675492
67RPS6KA41.05286708
68DAPK21.01277745
69MARK31.00969170
70MAP3K131.00764212
71STK38L0.97741476
72PTK2B0.95494115
73TAOK30.94276965
74VRK10.91075936
75PLK10.90855914
76PIK3CA0.89516231
77IKBKB0.89404542
78CAMKK20.89195192
79GRK10.85322036
80EPHA20.85097072
81MAP3K60.84783600
82RPS6KB20.84780886
83IRAK20.84768283
84EPHA30.82794027
85PDPK10.81064674
86BUB10.80507642
87STK160.80307433
88SIK30.78773311
89CDC70.78697640
90MARK20.78434508
91CHEK20.75105865
92LRRK20.74646919
93MAP2K40.73779515
94MAP3K20.72292115
95FGFR30.71560284
96PRKCQ0.70887224
97BLK0.69015918
98PASK0.67176647
99STK100.67175268
100NEK90.65296860
101TEC0.63705806
102FYN0.63642021
103MAPK120.61956504
104NLK0.60950733
105STK110.58111226
106PTK60.56684405
107PRKD20.52386487
108SCYL20.51523295
109MAP3K50.50906310
110SGK30.49714677
111CDC42BPA0.49674407
112MAP3K80.48055153
113MYLK0.47536470
114SGK20.47407270
115CCNB10.46917025
116KSR10.45892548
117RET0.45830295
118BRSK20.44730335
119STK240.42679758
120MAP3K110.42207561
121GRK70.42011504
122ADRBK20.41112215
123MELK0.40910827
124HIPK20.40591607
125ABL20.40375513
126PIM10.39933572
127MAPK70.39578506
128ADRBK10.38581765
129RPS6KA60.37952517
130PRKAA20.36621094
131PAK40.35907507
132RPS6KC10.35889822
133RPS6KL10.35889822
134PIK3CG0.35853573
135PAK10.35566772
136AURKA0.35543166
137CSNK2A10.35266783
138FGFR40.35067794
139PRKCD0.34106907
140TAOK20.33840516
141STK40.33791421
142PRKCZ0.32741166
143RAF10.31987806
144ABL10.31542001
145CDK90.28623779
146KDR0.28348475
147MAPKAPK20.28340362
148WEE10.27590668
149CSNK2A20.26910419
150STK380.24920252
151* PRKCA0.22363139
152ATM0.22257827
153TBK10.21622461
154PDK10.21500747
155IRAK10.21445962
156MAPK150.20688794
157CAMK10.20624078
158STK30.20318093
159MAP2K10.19587701
160CDK40.19339659
161PRKCI0.19297237
162EIF2AK20.19277369
163MATK0.18015830
164CDK70.17930122
165CAMK2D0.17501525
166CHEK10.16887841
167CSNK1A10.16739664
168CAMK2G0.15639148
169ATR0.15268736
170MAP3K70.15001555
171DYRK1B0.14446182
172CSNK1E0.14287132
173ERN10.13925615
174PRKACA0.12982573
175ERBB40.12324115
176FLT30.12012473
177BCR0.11360212
178ROCK10.11302232
179MAPK110.11274825
180PRKDC0.11026747

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.03130328
2Oxidative phosphorylation_Homo sapiens_hsa001903.63459578
3Staphylococcus aureus infection_Homo sapiens_hsa051503.35078564
4Parkinsons disease_Homo sapiens_hsa050123.26819220
5Leishmaniasis_Homo sapiens_hsa051403.11236829
6Homologous recombination_Homo sapiens_hsa034402.92358340
7Osteoclast differentiation_Homo sapiens_hsa043802.89456486
8Huntingtons disease_Homo sapiens_hsa050162.83620152
9Alzheimers disease_Homo sapiens_hsa050102.60283177
10Mismatch repair_Homo sapiens_hsa034302.56427887
11Graft-versus-host disease_Homo sapiens_hsa053322.48391491
12Allograft rejection_Homo sapiens_hsa053302.47092587
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.43915954
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.40117299
15Pentose phosphate pathway_Homo sapiens_hsa000302.32119777
16Autoimmune thyroid disease_Homo sapiens_hsa053202.32058445
17Tuberculosis_Homo sapiens_hsa051522.30651482
18Folate biosynthesis_Homo sapiens_hsa007902.11290724
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04007716
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03585241
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96010907
22B cell receptor signaling pathway_Homo sapiens_hsa046621.92680563
23Sulfur metabolism_Homo sapiens_hsa009201.89929425
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88324795
25Type I diabetes mellitus_Homo sapiens_hsa049401.87250125
26Hematopoietic cell lineage_Homo sapiens_hsa046401.84748294
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83923246
28Asthma_Homo sapiens_hsa053101.81251631
29Mineral absorption_Homo sapiens_hsa049781.80936224
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.80552809
31Cardiac muscle contraction_Homo sapiens_hsa042601.80491720
32Pyrimidine metabolism_Homo sapiens_hsa002401.76918355
33DNA replication_Homo sapiens_hsa030301.70323644
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69363315
35Antigen processing and presentation_Homo sapiens_hsa046121.69213855
36Malaria_Homo sapiens_hsa051441.69172099
37Glutathione metabolism_Homo sapiens_hsa004801.68591311
38Chemokine signaling pathway_Homo sapiens_hsa040621.67745895
39Phagosome_Homo sapiens_hsa041451.61708769
40Primary immunodeficiency_Homo sapiens_hsa053401.59904747
41Pyruvate metabolism_Homo sapiens_hsa006201.52279695
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50647012
43Fat digestion and absorption_Homo sapiens_hsa049751.50424709
44Other glycan degradation_Homo sapiens_hsa005111.46452675
45Toxoplasmosis_Homo sapiens_hsa051451.44148774
46Nitrogen metabolism_Homo sapiens_hsa009101.42269616
47Measles_Homo sapiens_hsa051621.40637379
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.38971549
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35858623
50Fanconi anemia pathway_Homo sapiens_hsa034601.32026303
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31824880
52Fructose and mannose metabolism_Homo sapiens_hsa000511.30464706
53T cell receptor signaling pathway_Homo sapiens_hsa046601.30055171
54Rheumatoid arthritis_Homo sapiens_hsa053231.29458921
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29221144
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28783068
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27577149
58Platelet activation_Homo sapiens_hsa046111.26731046
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25657891
60Lysosome_Homo sapiens_hsa041421.24178045
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.24134503
62Viral myocarditis_Homo sapiens_hsa054161.22243971
63Fatty acid degradation_Homo sapiens_hsa000711.20347501
64Propanoate metabolism_Homo sapiens_hsa006401.19307173
65One carbon pool by folate_Homo sapiens_hsa006701.18369752
66Histidine metabolism_Homo sapiens_hsa003401.18219824
67Carbon metabolism_Homo sapiens_hsa012001.16080363
68Acute myeloid leukemia_Homo sapiens_hsa052211.15392676
69Cyanoamino acid metabolism_Homo sapiens_hsa004601.14360665
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13777433
71TNF signaling pathway_Homo sapiens_hsa046681.11836732
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09553570
73Drug metabolism - other enzymes_Homo sapiens_hsa009831.06240209
74Purine metabolism_Homo sapiens_hsa002301.05979459
75Pancreatic secretion_Homo sapiens_hsa049721.04947136
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03561191
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03318974
78Intestinal immune network for IgA production_Homo sapiens_hsa046721.02801106
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01646613
80Herpes simplex infection_Homo sapiens_hsa051681.01047496
81African trypanosomiasis_Homo sapiens_hsa051430.99094779
82Bile secretion_Homo sapiens_hsa049760.98277156
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96147193
84RNA polymerase_Homo sapiens_hsa030200.95555883
85Butanoate metabolism_Homo sapiens_hsa006500.94412183
86Renin-angiotensin system_Homo sapiens_hsa046140.92932363
87Chemical carcinogenesis_Homo sapiens_hsa052040.90864919
88Tryptophan metabolism_Homo sapiens_hsa003800.89043391
89Glycerolipid metabolism_Homo sapiens_hsa005610.88569164
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87347199
91Retinol metabolism_Homo sapiens_hsa008300.86643767
92Metabolic pathways_Homo sapiens_hsa011000.83639461
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83391913
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82733298
95Base excision repair_Homo sapiens_hsa034100.82163142
96Arginine and proline metabolism_Homo sapiens_hsa003300.81122982
97* Protein digestion and absorption_Homo sapiens_hsa049740.79024171
98Hepatitis B_Homo sapiens_hsa051610.78946227
99Spliceosome_Homo sapiens_hsa030400.78832736
100Selenocompound metabolism_Homo sapiens_hsa004500.78696682
101Arachidonic acid metabolism_Homo sapiens_hsa005900.78025427
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75822202
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75421628
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74846875
105Linoleic acid metabolism_Homo sapiens_hsa005910.74170418
106Apoptosis_Homo sapiens_hsa042100.72462621
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72431876
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72407365
109Dorso-ventral axis formation_Homo sapiens_hsa043200.72363722
110Proteasome_Homo sapiens_hsa030500.72047527
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.70226368
112RNA transport_Homo sapiens_hsa030130.69861137
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69696357
114Non-small cell lung cancer_Homo sapiens_hsa052230.69389506
115Protein export_Homo sapiens_hsa030600.67864413
116Collecting duct acid secretion_Homo sapiens_hsa049660.67388927
117Tight junction_Homo sapiens_hsa045300.67208687
118N-Glycan biosynthesis_Homo sapiens_hsa005100.65465232
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64823387
120Nucleotide excision repair_Homo sapiens_hsa034200.62973121
121Endocytosis_Homo sapiens_hsa041440.60517158
122Regulation of autophagy_Homo sapiens_hsa041400.60337301
123Shigellosis_Homo sapiens_hsa051310.60254417
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60088163
125Pancreatic cancer_Homo sapiens_hsa052120.59763937
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.59560742
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.59318188
128Prolactin signaling pathway_Homo sapiens_hsa049170.59229729
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.56040794
130Gastric acid secretion_Homo sapiens_hsa049710.54993659
131VEGF signaling pathway_Homo sapiens_hsa043700.54858357
132Amoebiasis_Homo sapiens_hsa051460.54329550
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.53146205
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52330960
135Systemic lupus erythematosus_Homo sapiens_hsa053220.49741107
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49433021
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.49049073
138GnRH signaling pathway_Homo sapiens_hsa049120.48426482
139Galactose metabolism_Homo sapiens_hsa000520.47911247
140Notch signaling pathway_Homo sapiens_hsa043300.47740208
141Renal cell carcinoma_Homo sapiens_hsa052110.47711905
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.47637268
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47074365
144Starch and sucrose metabolism_Homo sapiens_hsa005000.46763160
145Choline metabolism in cancer_Homo sapiens_hsa052310.46236266
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45835678
147Basal transcription factors_Homo sapiens_hsa030220.45768148
148Complement and coagulation cascades_Homo sapiens_hsa046100.45235529
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43504154
150Vitamin digestion and absorption_Homo sapiens_hsa049770.43394182
151Thyroid hormone synthesis_Homo sapiens_hsa049180.43186096
152FoxO signaling pathway_Homo sapiens_hsa040680.41979604
153Insulin resistance_Homo sapiens_hsa049310.41059723
154Vibrio cholerae infection_Homo sapiens_hsa051100.41021608
155NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40981774
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40558851
157Ether lipid metabolism_Homo sapiens_hsa005650.40358554
158Bladder cancer_Homo sapiens_hsa052190.40273259
159Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39691479
160Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38146424
161Chronic myeloid leukemia_Homo sapiens_hsa052200.37656774
162Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37382078
163HIF-1 signaling pathway_Homo sapiens_hsa040660.36903038
164Type II diabetes mellitus_Homo sapiens_hsa049300.36767141
165Hepatitis C_Homo sapiens_hsa051600.36143143
166Influenza A_Homo sapiens_hsa051640.34759797
167Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34456908
168Sulfur relay system_Homo sapiens_hsa041220.31594673
169Legionellosis_Homo sapiens_hsa051340.30511251
170beta-Alanine metabolism_Homo sapiens_hsa004100.29010059
171Adherens junction_Homo sapiens_hsa045200.27811984
172ABC transporters_Homo sapiens_hsa020100.27321359
173Sphingolipid metabolism_Homo sapiens_hsa006000.26195265
174PPAR signaling pathway_Homo sapiens_hsa033200.23645384
175Pertussis_Homo sapiens_hsa051330.22053018
176Salmonella infection_Homo sapiens_hsa051320.21646187
177Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18741453
178Steroid hormone biosynthesis_Homo sapiens_hsa001400.18648091
179Vitamin B6 metabolism_Homo sapiens_hsa007500.17104067

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