KCNE5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.85124783
2viral transcription (GO:0019083)5.74027186
3translational termination (GO:0006415)5.45021452
4chaperone-mediated protein transport (GO:0072321)5.38525896
5negative regulation of B cell apoptotic process (GO:0002903)5.34753942
6immunoglobulin mediated immune response (GO:0016064)5.11284966
7deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.97178184
8purine deoxyribonucleotide catabolic process (GO:0009155)4.78193203
9mature B cell differentiation involved in immune response (GO:0002313)4.74148625
10negative regulation of growth of symbiont in host (GO:0044130)4.72383503
11negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.72383503
12modulation of growth of symbiont involved in interaction with host (GO:0044144)4.72383503
13regulation of growth of symbiont in host (GO:0044126)4.72383503
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.71060967
15cotranslational protein targeting to membrane (GO:0006613)4.62669065
16protein targeting to ER (GO:0045047)4.60862983
17translational elongation (GO:0006414)4.60006251
18purine nucleotide salvage (GO:0032261)4.52727466
19protein localization to endoplasmic reticulum (GO:0070972)4.41391711
20regulation of germinal center formation (GO:0002634)4.38533004
21ribosomal small subunit assembly (GO:0000028)4.36651767
22inner mitochondrial membrane organization (GO:0007007)4.36409325
23purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.35184949
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.34477005
25chaperone mediated protein folding requiring cofactor (GO:0051085)4.33328110
26phosphatidylglycerol biosynthetic process (GO:0006655)4.31918828
27ribosomal small subunit biogenesis (GO:0042274)4.28212788
28cellular protein complex disassembly (GO:0043624)4.26494679
29viral life cycle (GO:0019058)4.02540532
30negative regulation of multicellular organism growth (GO:0040015)3.97133932
31nucleotide salvage (GO:0043173)3.91088822
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91038136
33B cell mediated immunity (GO:0019724)3.91027610
34cell wall macromolecule catabolic process (GO:0016998)3.89277568
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.79324958
36response to peptidoglycan (GO:0032494)3.78100567
37neutrophil activation involved in immune response (GO:0002283)3.65391272
38positive regulation of antigen processing and presentation (GO:0002579)3.60843481
39protein complex disassembly (GO:0043241)3.59926929
40deoxyribonucleotide catabolic process (GO:0009264)3.55134400
41purine deoxyribonucleotide metabolic process (GO:0009151)3.54281794
42cellular response to interferon-beta (GO:0035458)3.46545308
43translational initiation (GO:0006413)3.45738543
44ATP synthesis coupled proton transport (GO:0015986)3.39074542
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39074542
46deoxyribose phosphate catabolic process (GO:0046386)3.37920127
47maturation of SSU-rRNA (GO:0030490)3.37706145
48cell wall macromolecule metabolic process (GO:0044036)3.35733795
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.33523106
50NADH dehydrogenase complex assembly (GO:0010257)3.33523106
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33523106
52reactive oxygen species biosynthetic process (GO:1903409)3.33222752
53positive regulation of B cell differentiation (GO:0045579)3.30023964
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29063527
55macromolecular complex disassembly (GO:0032984)3.26977119
56DNA strand elongation involved in DNA replication (GO:0006271)3.23756115
57UV protection (GO:0009650)3.22326773
58regulation of B cell apoptotic process (GO:0002902)3.21811022
59glucosamine-containing compound catabolic process (GO:1901072)3.16136636
60indole-containing compound catabolic process (GO:0042436)3.13619260
61indolalkylamine catabolic process (GO:0046218)3.13619260
62tryptophan catabolic process (GO:0006569)3.13619260
63protein complex biogenesis (GO:0070271)3.13022704
64positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.12947880
65cytochrome complex assembly (GO:0017004)3.12480917
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10981283
67DNA strand elongation (GO:0022616)3.07755783
682-deoxyribonucleotide metabolic process (GO:0009394)3.07564167
69telomere maintenance via semi-conservative replication (GO:0032201)3.05190390
70mature B cell differentiation (GO:0002335)3.03615141
71regulation of mitochondrial translation (GO:0070129)2.99142012
72protein targeting to membrane (GO:0006612)2.96364019
73deoxyribose phosphate metabolic process (GO:0019692)2.89130049
74respiratory electron transport chain (GO:0022904)2.89014148
75negative regulation of tissue remodeling (GO:0034104)2.88305384
76negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.88092599
77circadian sleep/wake cycle process (GO:0022410)2.86708304
78purine-containing compound salvage (GO:0043101)2.86266168
79electron transport chain (GO:0022900)2.86193301
80mitochondrial respiratory chain complex assembly (GO:0033108)2.85103534
81RNA catabolic process (GO:0006401)2.83382956
82neurotransmitter catabolic process (GO:0042135)2.82072248
83regulation of T-helper 1 cell differentiation (GO:0045625)2.80211155
84regulation of antigen processing and presentation (GO:0002577)2.77678957
85nuclear-transcribed mRNA catabolic process (GO:0000956)2.75340901
862-deoxyribonucleotide biosynthetic process (GO:0009265)2.74390029
87deoxyribose phosphate biosynthetic process (GO:0046385)2.74390029
88rRNA modification (GO:0000154)2.74090211
89telomere maintenance via recombination (GO:0000722)2.73649534
90regulation of hypersensitivity (GO:0002883)2.73262296
91mRNA catabolic process (GO:0006402)2.72999944
92defense response to protozoan (GO:0042832)2.71239347
93translation (GO:0006412)2.67184518
94response to folic acid (GO:0051593)2.66812398
95purine nucleobase biosynthetic process (GO:0009113)2.66325473
96tryptophan metabolic process (GO:0006568)2.64855290
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.63618994
98microglial cell activation (GO:0001774)2.61296607
99galactose catabolic process (GO:0019388)2.60089301
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59134114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.59600573
2VDR_21846776_ChIP-Seq_THP-1_Human4.39706734
3VDR_24763502_ChIP-Seq_THP-1_Human3.68822587
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.58456126
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35787532
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28117468
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.18518284
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89648886
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82294320
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.75874363
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.70575212
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.63806934
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60976669
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59454050
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.52501816
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.39874040
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.34176380
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29200845
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.26340768
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21016492
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19511256
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17492735
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15896206
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12727560
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.11015985
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10678399
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01434509
28SPI1_23547873_ChIP-Seq_NB4_Human1.96440435
29FOXP3_21729870_ChIP-Seq_TREG_Human1.92252782
30SCL_19346495_ChIP-Seq_HPC-7_Human1.88445668
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.83449511
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79238513
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.76131016
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75196856
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74273474
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71898180
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69489103
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64489361
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64010681
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63573499
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63369345
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58668375
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52829669
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48458987
45VDR_23849224_ChIP-Seq_CD4+_Human1.45079865
46UTX_26944678_Chip-Seq_JUKART_Human1.43749655
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39317550
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37784380
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34014665
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31902512
51STAT1_20625510_ChIP-Seq_HELA_Human1.30999169
52XRN2_22483619_ChIP-Seq_HELA_Human1.29903135
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28749404
54GABP_19822575_ChIP-Seq_HepG2_Human1.28643965
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.26591598
56TTF2_22483619_ChIP-Seq_HELA_Human1.26033432
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25651047
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23491916
59SPI1_20517297_ChIP-Seq_HL60_Human1.22754024
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21041832
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20040142
62PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19984076
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19472149
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17691699
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17378964
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.16306491
67CIITA_25753668_ChIP-Seq_RAJI_Human1.14880451
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14847431
69BCL6_27268052_Chip-Seq_Bcells_Human1.14044272
70E2F1_20622854_ChIP-Seq_HELA_Human1.13690005
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12931686
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11069132
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08976635
74MYB_26560356_Chip-Seq_TH2_Human1.07457969
75SPI1_23127762_ChIP-Seq_K562_Human1.07141398
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06943347
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.06840484
78KDM5A_27292631_Chip-Seq_BREAST_Human1.04653824
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04129141
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03930592
81LXR_22292898_ChIP-Seq_THP-1_Human1.01439421
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01433470
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00700866
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00062875
85MYC_22102868_ChIP-Seq_BL_Human0.98863862
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97419707
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.97267506
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97158322
89ERG_20517297_ChIP-Seq_VCAP_Human0.95888654
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94911022
91MAF_26560356_Chip-Seq_TH1_Human0.94753949
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94118905
93DCP1A_22483619_ChIP-Seq_HELA_Human0.94073502
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93914547
95BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93689644
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.92008667
97TAF2_19829295_ChIP-Seq_ESCs_Human0.91443269
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.91389859
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91266739
100VDR_24787735_ChIP-Seq_THP-1_Human0.91020332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo3.90607187
2MP0003136_yellow_coat_color3.63560989
3MP0001835_abnormal_antigen_presentation3.34265517
4MP0009379_abnormal_foot_pigmentation3.12457515
5MP0002653_abnormal_ependyma_morphology3.06042853
6MP0008007_abnormal_cellular_replicative2.80153940
7MP0009278_abnormal_bone_marrow2.77547752
8MP0002396_abnormal_hematopoietic_system2.74825934
9MP0000015_abnormal_ear_pigmentation2.42906497
10MP0010094_abnormal_chromosome_stability2.34510636
11MP0002419_abnormal_innate_immunity2.31054103
12MP0003172_abnormal_lysosome_physiology2.27555855
13MP0006036_abnormal_mitochondrial_physio2.24192496
14MP0008058_abnormal_DNA_repair2.21160238
15MP0002822_catalepsy2.18374269
16MP0003075_altered_response_to2.12694957
17MP0002148_abnormal_hypersensitivity_rea2.10978715
18MP0008875_abnormal_xenobiotic_pharmacok2.05625005
19MP0001905_abnormal_dopamine_level1.98739077
20MP0005360_urolithiasis1.90627048
21MP0005025_abnormal_response_to1.87393565
22MP0001800_abnormal_humoral_immune1.83760525
23MP0005075_abnormal_melanosome_morpholog1.83193968
24MP0002735_abnormal_chemical_nociception1.76198215
25MP0003806_abnormal_nucleotide_metabolis1.73903518
26MP0002420_abnormal_adaptive_immunity1.71899081
27MP0001853_heart_inflammation1.71756025
28MP0001986_abnormal_taste_sensitivity1.66520771
29MP0004742_abnormal_vestibular_system1.66308878
30MP0001819_abnormal_immune_cell1.66060564
31MP0002452_abnormal_antigen_presenting1.65950718
32MP0002723_abnormal_immune_serum1.58514677
33MP0003436_decreased_susceptibility_to1.55202403
34MP0002095_abnormal_skin_pigmentation1.46026184
35MP0000858_altered_metastatic_potential1.45477813
36MP0005000_abnormal_immune_tolerance1.45216034
37MP0005165_increased_susceptibility_to1.39506169
38MP0009697_abnormal_copulation1.38653270
39MP0000343_altered_response_to1.38216894
40MP0005397_hematopoietic_system_phenotyp1.37878704
41MP0001545_abnormal_hematopoietic_system1.37878704
42MP0002398_abnormal_bone_marrow1.36787476
43MP0006035_abnormal_mitochondrial_morpho1.35838246
44MP0005464_abnormal_platelet_physiology1.35674640
45MP0000716_abnormal_immune_system1.28930613
46MP0009764_decreased_sensitivity_to1.27859448
47MP0005058_abnormal_lysosome_morphology1.27667250
48MP0003186_abnormal_redox_activity1.24987331
49MP0003943_abnormal_hepatobiliary_system1.24590787
50MP0001968_abnormal_touch/_nociception1.20035687
51MP0003252_abnormal_bile_duct1.17354535
52MP0002429_abnormal_blood_cell1.16832902
53MP0000689_abnormal_spleen_morphology1.15849592
54MP0002928_abnormal_bile_duct1.14628381
55MP0005423_abnormal_somatic_nervous1.14254337
56MP0002722_abnormal_immune_system1.13972808
57MP0005166_decreased_susceptibility_to1.11804162
58MP0003638_abnormal_response/metabolism_1.03414779
59MP0008469_abnormal_protein_level1.02920095
60MP0003786_premature_aging1.02036937
61MP0001764_abnormal_homeostasis1.00564739
62MP0004142_abnormal_muscle_tone1.00112067
63MP0009785_altered_susceptibility_to0.99568480
64MP0000685_abnormal_immune_system0.97862468
65MP0005266_abnormal_metabolism0.95622993
66MP0002163_abnormal_gland_morphology0.93805510
67MP0002019_abnormal_tumor_incidence0.92683967
68MP0003077_abnormal_cell_cycle0.88803460
69MP0003283_abnormal_digestive_organ0.86916965
70MP0003315_abnormal_perineum_morphology0.86395370
71MP0005330_cardiomyopathy0.83348013
72MP0008995_early_reproductive_senescence0.82445937
73MP0000372_irregular_coat_pigmentation0.82263537
74MP0000750_abnormal_muscle_regeneration0.81979793
75MP0002277_abnormal_respiratory_mucosa0.80796378
76MP0000703_abnormal_thymus_morphology0.80534764
77MP0010307_abnormal_tumor_latency0.79514298
78MP0001845_abnormal_inflammatory_respons0.76634529
79MP0002166_altered_tumor_susceptibility0.76164859
80MP0002405_respiratory_system_inflammati0.76036711
81MP0002009_preneoplasia0.74220392
82MP0001324_abnormal_eye_pigmentation0.74003098
83MP0005671_abnormal_response_to0.73146526
84MP0004147_increased_porphyrin_level0.72950629
85MP0009763_increased_sensitivity_to0.72557225
86MP0000465_gastrointestinal_hemorrhage0.71010340
87MP0002736_abnormal_nociception_after0.70393852
88MP0006072_abnormal_retinal_apoptosis0.69079914
89MP0004808_abnormal_hematopoietic_stem0.68163470
90MP0005319_abnormal_enzyme/_coenzyme0.68000390
91MP0008877_abnormal_DNA_methylation0.67587069
92MP0005410_abnormal_fertilization0.67549410
93MP0001970_abnormal_pain_threshold0.66652648
94MP0008872_abnormal_physiological_respon0.64945631
95MP0008057_abnormal_DNA_replication0.64556959
96MP0005376_homeostasis/metabolism_phenot0.63798753
97MP0004957_abnormal_blastocyst_morpholog0.61862467
98MP0001963_abnormal_hearing_physiology0.61666190
99MP0000249_abnormal_blood_vessel0.60104852
100MP0001790_abnormal_immune_system0.59426271

Predicted human phenotypes

RankGene SetZ-score
1Amyloidosis (HP:0011034)5.23664001
2Agammaglobulinemia (HP:0004432)5.15969426
3Abnormal number of erythroid precursors (HP:0012131)4.49357709
4Increased IgE level (HP:0003212)4.33408105
5Abnormality of cells of the erythroid lineage (HP:0012130)4.08354493
6Chronic mucocutaneous candidiasis (HP:0002728)3.94474009
7Recurrent cutaneous fungal infections (HP:0011370)3.94474009
8Chronic obstructive pulmonary disease (HP:0006510)3.92478346
9Obstructive lung disease (HP:0006536)3.92478346
10Reticulocytopenia (HP:0001896)3.50242536
11Panhypogammaglobulinemia (HP:0003139)3.47087256
12Thrombocytosis (HP:0001894)3.45182487
13Distal arthrogryposis (HP:0005684)3.39981329
14B lymphocytopenia (HP:0010976)3.21283256
15Polygenic inheritance (HP:0010982)3.18532477
16Macrocytic anemia (HP:0001972)3.13823477
17Recurrent fungal infections (HP:0002841)3.10695140
18Recurrent gram-negative bacterial infections (HP:0005420)3.03955360
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.03260422
20Abnormality of the prostate (HP:0008775)3.03204762
21Meningitis (HP:0001287)2.99036502
22Type 2 muscle fiber atrophy (HP:0003554)2.94720159
23Hepatocellular necrosis (HP:0001404)2.92324182
24Abnormality of B cell number (HP:0010975)2.92210850
25Weak cry (HP:0001612)2.82320584
26Microvesicular hepatic steatosis (HP:0001414)2.80329077
27Acute lymphatic leukemia (HP:0006721)2.78872660
28Muscle fiber atrophy (HP:0100295)2.76546446
29Elevated erythrocyte sedimentation rate (HP:0003565)2.75064460
30Recurrent skin infections (HP:0001581)2.60285251
31Recurrent lower respiratory tract infections (HP:0002783)2.59131548
32Nemaline bodies (HP:0003798)2.57196851
33Mitochondrial inheritance (HP:0001427)2.55662613
34Calcaneovalgus deformity (HP:0001848)2.48664045
35Multiple enchondromatosis (HP:0005701)2.46951214
36Absent/shortened dynein arms (HP:0200106)2.46432420
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.46432420
38Colon cancer (HP:0003003)2.46417230
39Pallor (HP:0000980)2.43891322
40Mediastinal lymphadenopathy (HP:0100721)2.41201119
41Aplasia/Hypoplasia of the thymus (HP:0010515)2.37355868
42Hepatic necrosis (HP:0002605)2.34624512
43Recurrent pneumonia (HP:0006532)2.34476302
44Duplicated collecting system (HP:0000081)2.33935134
45Colitis (HP:0002583)2.31923944
46Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27308510
47Granulocytopenia (HP:0001913)2.25632903
48Renal Fanconi syndrome (HP:0001994)2.25520015
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23901485
50Verrucae (HP:0200043)2.23022668
51Papilloma (HP:0012740)2.23022668
52Sepsis (HP:0100806)2.22905189
53Severe combined immunodeficiency (HP:0004430)2.22366495
54Recurrent viral infections (HP:0004429)2.21842177
55Abnormality of male internal genitalia (HP:0000022)2.20630451
56Recurrent bacterial skin infections (HP:0005406)2.20584789
57Chronic sinusitis (HP:0011109)2.19666627
58Increased intramyocellular lipid droplets (HP:0012240)2.19354245
59Abnormality of DNA repair (HP:0003254)2.18738905
60Gastrointestinal inflammation (HP:0004386)2.15933457
61Hypertensive crisis (HP:0100735)2.12261004
62Recurrent abscess formation (HP:0002722)2.11205435
63Muscle fiber inclusion bodies (HP:0100299)2.11151283
64Abnormal mitochondria in muscle tissue (HP:0008316)2.11083122
65Exertional dyspnea (HP:0002875)2.11026844
66Bulbar palsy (HP:0001283)2.10202302
67Deformed tarsal bones (HP:0008119)2.07747635
68Paralysis (HP:0003470)2.06719555
69Increased CSF lactate (HP:0002490)2.05595303
70Autoimmune thrombocytopenia (HP:0001973)2.04885020
71Abnormality of the renal collecting system (HP:0004742)2.02312704
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01755319
73Skin rash (HP:0000988)2.01615090
74Acute necrotizing encephalopathy (HP:0006965)2.01016047
75Pulmonary fibrosis (HP:0002206)1.99856759
76Increased hepatocellular lipid droplets (HP:0006565)1.98100066
77Prominent metopic ridge (HP:0005487)1.94849661
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93683672
79Poikiloderma (HP:0001029)1.92742208
80Hypergammaglobulinemia (HP:0010702)1.90681958
81Prostate neoplasm (HP:0100787)1.88401635
82True hermaphroditism (HP:0010459)1.87726403
83Rhabdomyolysis (HP:0003201)1.84479822
84Tubulointerstitial nephritis (HP:0001970)1.84435003
85Inflammation of the large intestine (HP:0002037)1.82683992
86Macular degeneration (HP:0000608)1.82319300
87Increased muscle lipid content (HP:0009058)1.81431367
88Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81091813
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81091813
90Cellulitis (HP:0100658)1.80353626
91Abnormality of the pleura (HP:0002103)1.78638338
92Abnormality of T cell physiology (HP:0011840)1.76504377
93Eczematoid dermatitis (HP:0000976)1.76285815
94Spondylolisthesis (HP:0003302)1.72829113
95Lipid accumulation in hepatocytes (HP:0006561)1.71879694
96Testicular atrophy (HP:0000029)1.71588888
97Hypoglycemic seizures (HP:0002173)1.71117806
98Chest pain (HP:0100749)1.71036685
99Mesangial abnormality (HP:0001966)1.70744148
100Fatigable weakness (HP:0003473)1.68979442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.32002824
2MAPK153.80063410
3TSSK63.77823797
4PNCK3.64760916
5TESK23.25181386
6STK162.90232752
7KDR2.70116191
8KIT2.64681946
9RIPK42.45461258
10VRK12.38678806
11FLT32.22332387
12MAP4K12.16998526
13BCKDK2.08658261
14TAF12.01684781
15MOS1.99650888
16ARAF1.98721174
17GRK71.89450936
18CSF1R1.77346361
19TBK11.75265911
20CDK191.66605220
21WEE11.65121200
22CDC71.61253472
23PIM21.59968230
24ABL21.54040173
25TNK21.52970635
26BMPR21.49983321
27TAOK31.45786280
28PIK3CG1.42761000
29MAPKAPK51.41358793
30TYK21.33716830
31IKBKB1.33574425
32TESK11.33025581
33FES1.20650015
34GRK51.17366712
35IRAK41.16018704
36NME21.07064657
37CDK81.00007281
38DYRK20.98843037
39LIMK10.96828558
40SCYL20.96017240
41NUAK10.94731915
42SYK0.94512515
43TEC0.87815133
44MAPKAPK30.81784512
45LYN0.77978643
46IRAK20.75843700
47TIE10.74808375
48LRRK20.71959788
49OBSCN0.71716249
50RET0.70272577
51DAPK10.68223331
52RPS6KB20.67192333
53PLK40.65891676
54TGFBR20.64848577
55RPS6KA40.63112393
56SMG10.62822106
57EIF2AK20.61917739
58IRAK10.60847416
59ATR0.60625180
60PKN10.59564625
61IKBKE0.57294173
62ZAP700.56866589
63CDK90.56610400
64MAPK40.55725233
65RAF10.54859948
66MAPK70.54751410
67PINK10.54380772
68STK100.52914578
69CSNK1G30.49831182
70MAPK120.49554851
71CDK30.46695561
72PRKD10.46412962
73TXK0.44267721
74RPS6KA50.43043846
75MAP2K20.41153197
76GRK60.41093758
77BLK0.40923602
78LCK0.40611084
79MAPK130.38999883
80CSNK1G20.38939901
81ADRBK10.38912449
82ADRBK20.38260341
83CSNK2A20.36184207
84MAP3K70.36013146
85NEK90.34652393
86CDK40.34499215
87MAP3K110.33552941
88ABL10.33090776
89MAP2K30.32380700
90PIM10.31583761
91CSNK2A10.30673238
92MAP3K50.29204113
93MUSK0.28307029
94NTRK20.28270057
95CSNK1A1L0.28027792
96CSNK1G10.27328286
97AURKB0.26734647
98IRAK30.26387086
99MAP4K20.26254181
100DYRK1B0.24709223

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.75509710
2DNA replication_Homo sapiens_hsa030304.53116908
3Asthma_Homo sapiens_hsa053103.83187042
4Oxidative phosphorylation_Homo sapiens_hsa001902.93643230
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.84889179
6Mismatch repair_Homo sapiens_hsa034302.77556057
7Base excision repair_Homo sapiens_hsa034102.63710432
8Parkinsons disease_Homo sapiens_hsa050122.60147280
9Homologous recombination_Homo sapiens_hsa034402.58887096
10Allograft rejection_Homo sapiens_hsa053302.53219514
11Antigen processing and presentation_Homo sapiens_hsa046122.48928849
12Graft-versus-host disease_Homo sapiens_hsa053322.37565925
13Autoimmune thyroid disease_Homo sapiens_hsa053202.36644782
14Leishmaniasis_Homo sapiens_hsa051402.09808966
15Proteasome_Homo sapiens_hsa030502.07365346
16Primary immunodeficiency_Homo sapiens_hsa053401.96120476
17Fanconi anemia pathway_Homo sapiens_hsa034601.95779238
18Huntingtons disease_Homo sapiens_hsa050161.91736983
19Type I diabetes mellitus_Homo sapiens_hsa049401.90062449
20RNA polymerase_Homo sapiens_hsa030201.79752872
21Rheumatoid arthritis_Homo sapiens_hsa053231.74071202
22Nucleotide excision repair_Homo sapiens_hsa034201.72780351
23Staphylococcus aureus infection_Homo sapiens_hsa051501.65300464
24Alzheimers disease_Homo sapiens_hsa050101.60557261
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59120138
26Viral myocarditis_Homo sapiens_hsa054161.59093135
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52149659
28Cardiac muscle contraction_Homo sapiens_hsa042601.51163690
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49195027
30Spliceosome_Homo sapiens_hsa030401.45861407
31Pyrimidine metabolism_Homo sapiens_hsa002401.41027775
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37254914
33Sulfur relay system_Homo sapiens_hsa041221.19431088
34Protein export_Homo sapiens_hsa030601.13588313
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12836016
36Glutathione metabolism_Homo sapiens_hsa004801.12690214
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05105749
38Purine metabolism_Homo sapiens_hsa002300.97825162
39Systemic lupus erythematosus_Homo sapiens_hsa053220.95501230
40Peroxisome_Homo sapiens_hsa041460.90742175
41Influenza A_Homo sapiens_hsa051640.90621385
42Tuberculosis_Homo sapiens_hsa051520.89967646
43Epstein-Barr virus infection_Homo sapiens_hsa051690.85305428
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84914696
45Legionellosis_Homo sapiens_hsa051340.84284922
46Pertussis_Homo sapiens_hsa051330.81877032
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.74720233
48Ether lipid metabolism_Homo sapiens_hsa005650.72965295
49Toxoplasmosis_Homo sapiens_hsa051450.72688421
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70718863
51Hematopoietic cell lineage_Homo sapiens_hsa046400.68059481
52One carbon pool by folate_Homo sapiens_hsa006700.67237624
53Tryptophan metabolism_Homo sapiens_hsa003800.66426572
54Herpes simplex infection_Homo sapiens_hsa051680.61415018
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58005654
56Renin-angiotensin system_Homo sapiens_hsa046140.57923000
57Phototransduction_Homo sapiens_hsa047440.57162424
58Nitrogen metabolism_Homo sapiens_hsa009100.56869732
59Osteoclast differentiation_Homo sapiens_hsa043800.49683770
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49429967
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47514837
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47203096
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45097187
64Salivary secretion_Homo sapiens_hsa049700.42624269
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42365286
66Fatty acid elongation_Homo sapiens_hsa000620.41380209
67Non-homologous end-joining_Homo sapiens_hsa034500.40455575
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39957841
69B cell receptor signaling pathway_Homo sapiens_hsa046620.38562460
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38040762
71Metabolic pathways_Homo sapiens_hsa011000.35813040
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33331206
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.33254925
74Caffeine metabolism_Homo sapiens_hsa002320.33216641
75Phagosome_Homo sapiens_hsa041450.33095989
76Folate biosynthesis_Homo sapiens_hsa007900.30933444
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29650519
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29247831
79Butanoate metabolism_Homo sapiens_hsa006500.29096433
80Salmonella infection_Homo sapiens_hsa051320.28104803
81Arachidonic acid metabolism_Homo sapiens_hsa005900.27811759
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27397910
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27174538
84Notch signaling pathway_Homo sapiens_hsa043300.25191648
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23917219
86Measles_Homo sapiens_hsa051620.22616939
87Other glycan degradation_Homo sapiens_hsa005110.22360799
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21508348
89Fatty acid degradation_Homo sapiens_hsa000710.20636431
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.20087898
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18538696
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.17374899
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17360016
94Shigellosis_Homo sapiens_hsa051310.16646579
95HTLV-I infection_Homo sapiens_hsa051660.15521801
96Olfactory transduction_Homo sapiens_hsa047400.14278854
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13448519
98RNA transport_Homo sapiens_hsa030130.12764670
99Malaria_Homo sapiens_hsa051440.12741199
100RNA degradation_Homo sapiens_hsa030180.12389673

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