KCNF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.80663076
2synaptic vesicle maturation (GO:0016188)6.51981768
3locomotory exploration behavior (GO:0035641)6.39463548
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.96532432
5glutamate secretion (GO:0014047)5.96121111
6synaptic vesicle exocytosis (GO:0016079)5.91078742
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.79809772
8vocalization behavior (GO:0071625)5.79140057
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52892580
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.47805367
11regulation of synaptic vesicle exocytosis (GO:2000300)5.42977882
12regulation of glutamate receptor signaling pathway (GO:1900449)5.24358959
13protein localization to synapse (GO:0035418)4.99963689
14L-amino acid import (GO:0043092)4.98408198
15regulation of synaptic vesicle transport (GO:1902803)4.83047792
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.73503445
17regulation of neuronal synaptic plasticity (GO:0048168)4.71848781
18exploration behavior (GO:0035640)4.71097864
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.61754228
20amino acid import (GO:0043090)4.55908872
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.54142968
22neurotransmitter secretion (GO:0007269)4.53794056
23regulation of synapse structural plasticity (GO:0051823)4.45836858
24neuronal action potential propagation (GO:0019227)4.45724127
25neurotransmitter-gated ion channel clustering (GO:0072578)4.41504310
26synaptic transmission, glutamatergic (GO:0035249)4.34280018
27cerebellar granule cell differentiation (GO:0021707)4.33922106
28neuron cell-cell adhesion (GO:0007158)4.33077565
29layer formation in cerebral cortex (GO:0021819)4.30479530
30dendritic spine morphogenesis (GO:0060997)4.25841580
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.25352472
32glutamate receptor signaling pathway (GO:0007215)4.17329233
33proline transport (GO:0015824)4.14639262
34neuron-neuron synaptic transmission (GO:0007270)4.07531407
35negative regulation of dendrite morphogenesis (GO:0050774)4.04555845
36long-term memory (GO:0007616)4.02656409
37positive regulation of membrane potential (GO:0045838)4.00053304
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.97804822
39activation of protein kinase A activity (GO:0034199)3.95039445
40regulation of synaptic plasticity (GO:0048167)3.87467110
41positive regulation of dendritic spine morphogenesis (GO:0061003)3.85446490
42regulation of dendritic spine morphogenesis (GO:0061001)3.80338704
43regulation of postsynaptic membrane potential (GO:0060078)3.76359117
44gamma-aminobutyric acid transport (GO:0015812)3.76217403
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76047538
46potassium ion homeostasis (GO:0055075)3.75135593
47positive regulation of synapse maturation (GO:0090129)3.68364850
48cellular potassium ion homeostasis (GO:0030007)3.67682168
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.63735176
50long-term synaptic potentiation (GO:0060291)3.63683751
51regulation of neurotransmitter secretion (GO:0046928)3.61433122
52neurotransmitter transport (GO:0006836)3.55943783
53neuromuscular process controlling balance (GO:0050885)3.51233867
54neuron recognition (GO:0008038)3.49048206
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.48681754
56regulation of synapse maturation (GO:0090128)3.48636883
57positive regulation of neurotransmitter secretion (GO:0001956)3.46930869
58potassium ion import (GO:0010107)3.46420400
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44914457
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.43839567
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.42737680
62central nervous system myelination (GO:0022010)3.39671756
63axon ensheathment in central nervous system (GO:0032291)3.39671756
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38508953
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36671777
66regulation of vesicle fusion (GO:0031338)3.36575277
67positive regulation of neurotransmitter transport (GO:0051590)3.36419357
68synaptic vesicle endocytosis (GO:0048488)3.34186272
69postsynaptic membrane organization (GO:0001941)3.33737442
70sodium ion export (GO:0071436)3.31816315
71regulation of neurotransmitter transport (GO:0051588)3.30469353
72regulation of neurotransmitter levels (GO:0001505)3.29396424
73transmission of nerve impulse (GO:0019226)3.29329786
74regulation of dendritic spine development (GO:0060998)3.24981906
75dendritic spine organization (GO:0097061)3.24076386
76behavioral fear response (GO:0001662)3.22930470
77behavioral defense response (GO:0002209)3.22930470
78acidic amino acid transport (GO:0015800)3.21795216
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21161073
80axonal fasciculation (GO:0007413)3.20163365
81dendrite morphogenesis (GO:0048813)3.16454037
82cerebellar Purkinje cell layer development (GO:0021680)3.16056713
83membrane depolarization (GO:0051899)3.15979780
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15547673
85response to histamine (GO:0034776)3.14660940
86auditory behavior (GO:0031223)3.14415699
87negative regulation of amino acid transport (GO:0051956)3.12899583
88positive regulation of synaptic transmission (GO:0050806)3.11941103
89cell migration in hindbrain (GO:0021535)3.11114478
90regulation of synaptic transmission (GO:0050804)3.10807731
91vesicle docking involved in exocytosis (GO:0006904)3.10579418
92learning (GO:0007612)3.09801113
93neuromuscular synaptic transmission (GO:0007274)3.09760772
94positive regulation of dendrite development (GO:1900006)3.09331497
95cellular sodium ion homeostasis (GO:0006883)3.08744162
96vesicle transport along microtubule (GO:0047496)3.07961362
97fear response (GO:0042596)3.06968596
98membrane depolarization during action potential (GO:0086010)3.03664713
99response to auditory stimulus (GO:0010996)3.03360772
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02912374
101cerebellar Purkinje cell differentiation (GO:0021702)3.02904902
102* synaptic transmission (GO:0007268)3.01689122
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.01477180
104glycine transport (GO:0015816)3.00859335
105regulation of glutamate secretion (GO:0014048)3.00489644
106presynaptic membrane assembly (GO:0097105)3.00347411
107regulation of dendrite morphogenesis (GO:0048814)3.00265430
108neuromuscular process (GO:0050905)3.00022278
109social behavior (GO:0035176)2.99425359
110intraspecies interaction between organisms (GO:0051703)2.99425359
111synaptic vesicle transport (GO:0048489)2.98554783
112establishment of synaptic vesicle localization (GO:0097480)2.98554783
113regulation of exocytosis (GO:0017157)2.97493278
114regulation of voltage-gated calcium channel activity (GO:1901385)2.97436032
115prepulse inhibition (GO:0060134)2.97125914
116chemosensory behavior (GO:0007635)2.97092838
117dicarboxylic acid transport (GO:0006835)2.96970358
118neuronal ion channel clustering (GO:0045161)2.96697592
119positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94943493
120membrane hyperpolarization (GO:0060081)2.94826449
121regulation of ARF protein signal transduction (GO:0032012)2.92753937
122positive regulation of dendritic spine development (GO:0060999)2.91909195
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91823221
124behavioral response to cocaine (GO:0048148)2.91151448
125cell communication by electrical coupling (GO:0010644)2.90061118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38629025
2GBX2_23144817_ChIP-Seq_PC3_Human3.35304788
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18690889
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13452952
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08063756
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.02204660
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.85180071
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79042831
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79042831
10REST_21632747_ChIP-Seq_MESCs_Mouse2.77711840
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72276852
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66740975
13DROSHA_22980978_ChIP-Seq_HELA_Human2.63614341
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57862706
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57713252
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54000609
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51178242
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.49966252
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28875527
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.27101989
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.25713393
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23161924
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21379646
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11921665
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10412483
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93950474
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92969326
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89281185
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86509506
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.77909082
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.77114538
32AR_21572438_ChIP-Seq_LNCaP_Human1.76261430
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74736660
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73021777
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62883756
36TAF15_26573619_Chip-Seq_HEK293_Human1.58885950
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57230560
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.55497986
39* LXR_22292898_ChIP-Seq_THP-1_Human1.47600941
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.38887176
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38008492
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37960319
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34560092
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34510298
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34046998
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.32413737
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32110395
48* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28513288
49ZNF274_21170338_ChIP-Seq_K562_Hela1.27874069
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26846447
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.25686987
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25532800
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25095557
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24960771
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24516219
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23420219
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23319656
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22598557
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21194439
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21165084
61AR_19668381_ChIP-Seq_PC3_Human1.21133806
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21117215
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20369098
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19503427
65AR_25329375_ChIP-Seq_VCAP_Human1.19058951
66P300_19829295_ChIP-Seq_ESCs_Human1.19052429
67KDM2B_26808549_Chip-Seq_K562_Human1.15449663
68* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14144133
69STAT3_23295773_ChIP-Seq_U87_Human1.13559266
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13092047
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12399245
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12358063
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12319993
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11067711
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.09896517
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09816336
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.08440075
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07657666
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06709160
80* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05017359
81TCF4_23295773_ChIP-Seq_U87_Human1.03990238
82SMC4_20622854_ChIP-Seq_HELA_Human1.03956126
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03629842
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.03357961
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.02986089
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.00934256
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.00770194
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00439400
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00286523
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00183449
91* AHR_22903824_ChIP-Seq_MCF-7_Human0.99731252
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99337879
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99094792
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98387406
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98365671
96CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97796098
97OCT4_19829295_ChIP-Seq_ESCs_Human0.97027886
98RXR_22108803_ChIP-Seq_LS180_Human0.96585529
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95897100
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.95641619
101BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95484473
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95470973
103KDM2B_26808549_Chip-Seq_DND41_Human0.95298102
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.94927347
105* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93917793
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93695618
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93667012
108RNF2_27304074_Chip-Seq_NSC_Mouse0.93184404
109CREB1_26743006_Chip-Seq_LNCaP_Human0.92485572
110TP53_16413492_ChIP-PET_HCT116_Human0.91705356
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90891724
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90693455
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90557751
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90140444
115DPY_21335234_ChIP-Seq_ESCs_Mouse0.89936438
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89307732
117KLF4_19829295_ChIP-Seq_ESCs_Human0.88984716
118* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87717495
119* RUNX2_22187159_ChIP-Seq_PCA_Human0.87121178
120TET1_21490601_ChIP-Seq_MESCs_Mouse0.87001154
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86489460
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85716644
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.84714294
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.84657891
125* CTCF_27219007_Chip-Seq_Bcells_Human0.83554436
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83051689
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83051689
128P68_20966046_ChIP-Seq_HELA_Human0.82659797
129FUS_26573619_Chip-Seq_HEK293_Human0.82390196
130RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81543576
131* JUN_21703547_ChIP-Seq_K562_Human0.81484953
132EGR1_19032775_ChIP-ChIP_M12_Human0.81308552
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79956335
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.79336145
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77087481
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77000148
137MYC_19915707_ChIP-ChIP_AK7_Human0.76814242
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76008622
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.75591994
140SMAD4_21741376_ChIP-Seq_ESCs_Human0.75087381
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.73081235
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71548762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.36813662
2MP0003880_abnormal_central_pattern4.64606040
3MP0003635_abnormal_synaptic_transmissio4.43804439
4MP0004270_analgesia3.99512958
5MP0009745_abnormal_behavioral_response3.61253554
6MP0002063_abnormal_learning/memory/cond3.57928004
7MP0002064_seizures3.27147616
8MP0001968_abnormal_touch/_nociception3.17489040
9MP0002822_catalepsy3.16692406
10MP0009046_muscle_twitch2.98584224
11MP0002572_abnormal_emotion/affect_behav2.88999046
12MP0005423_abnormal_somatic_nervous2.81409685
13MP0002734_abnormal_mechanical_nocicepti2.72129213
14MP0001486_abnormal_startle_reflex2.57693621
15MP0002272_abnormal_nervous_system2.50473477
16MP0002736_abnormal_nociception_after2.43519089
17MP0009780_abnormal_chondrocyte_physiolo2.38878876
18MP0001501_abnormal_sleep_pattern2.27795403
19MP0002735_abnormal_chemical_nociception2.17659792
20MP0001440_abnormal_grooming_behavior2.15672552
21MP0001970_abnormal_pain_threshold1.98545734
22MP0003329_amyloid_beta_deposits1.98099331
23MP0002733_abnormal_thermal_nociception1.98014698
24MP0003879_abnormal_hair_cell1.92984616
25MP0008569_lethality_at_weaning1.87068168
26MP0002067_abnormal_sensory_capabilities1.80666356
27MP0004811_abnormal_neuron_physiology1.79711745
28MP0004858_abnormal_nervous_system1.73818423
29MP0002909_abnormal_adrenal_gland1.67921724
30MP0002557_abnormal_social/conspecific_i1.67067842
31MP0004924_abnormal_behavior1.61248980
32MP0005386_behavior/neurological_phenoty1.61248980
33MP0000778_abnormal_nervous_system1.61204567
34MP0002184_abnormal_innervation1.60232736
35MP0005646_abnormal_pituitary_gland1.57497820
36MP0003787_abnormal_imprinting1.51898296
37MP0000955_abnormal_spinal_cord1.41090553
38MP0002066_abnormal_motor_capabilities/c1.38786362
39MP0003633_abnormal_nervous_system1.36345281
40MP0004885_abnormal_endolymph1.35480444
41MP0002882_abnormal_neuron_morphology1.33075204
42MP0001984_abnormal_olfaction1.24919564
43MP0000751_myopathy1.19945860
44MP0005645_abnormal_hypothalamus_physiol1.17038829
45MP0003122_maternal_imprinting1.16443340
46MP0001502_abnormal_circadian_rhythm1.15832744
47MP0003631_nervous_system_phenotype1.12384680
48MP0001905_abnormal_dopamine_level1.10877827
49MP0000013_abnormal_adipose_tissue1.09822209
50MP0003075_altered_response_to1.08526225
51MP0006276_abnormal_autonomic_nervous1.08204780
52MP0002152_abnormal_brain_morphology1.05435027
53MP0008961_abnormal_basal_metabolism1.04204362
54MP0001177_atelectasis1.03555242
55MP0008872_abnormal_physiological_respon1.03329620
56MP0004142_abnormal_muscle_tone1.00605044
57MP0008874_decreased_physiological_sensi0.97994351
58MP0001529_abnormal_vocalization0.97592192
59MP0002069_abnormal_eating/drinking_beha0.95767816
60MP0003283_abnormal_digestive_organ0.91709159
61MP0010386_abnormal_urinary_bladder0.91618031
62MP0003183_abnormal_peptide_metabolism0.88187686
63MP0000604_amyloidosis0.87442066
64MP0001346_abnormal_lacrimal_gland0.86665111
65MP0010234_abnormal_vibrissa_follicle0.85939468
66MP0005623_abnormal_meninges_morphology0.85760663
67MP0003172_abnormal_lysosome_physiology0.82223760
68MP0001188_hyperpigmentation0.81549019
69MP0004085_abnormal_heartbeat0.80532805
70MP0005535_abnormal_body_temperature0.79324812
71MP0004145_abnormal_muscle_electrophysio0.78782689
72MP0002229_neurodegeneration0.76833486
73MP0002837_dystrophic_cardiac_calcinosis0.76680866
74MP0001664_abnormal_digestion0.75754074
75MP0002876_abnormal_thyroid_physiology0.75147401
76MP0000569_abnormal_digit_pigmentation0.73663911
77MP0001963_abnormal_hearing_physiology0.73582250
78MP0003690_abnormal_glial_cell0.73400383
79MP0005167_abnormal_blood-brain_barrier0.72975803
80MP0002090_abnormal_vision0.72575509
81MP0003632_abnormal_nervous_system0.70376753
82MP0004484_altered_response_of0.70120190
83MP0003634_abnormal_glial_cell0.67691690
84MP0004510_myositis0.66737958
85MP0002089_abnormal_postnatal_growth/wei0.66468374
86MP0004233_abnormal_muscle_weight0.65423473
87MP0001348_abnormal_lacrimal_gland0.64878880
88MP0000920_abnormal_myelination0.63133284
89MP0000579_abnormal_nail_morphology0.62272715
90MP0005394_taste/olfaction_phenotype0.62168112
91MP0005499_abnormal_olfactory_system0.62168112
92MP0004215_abnormal_myocardial_fiber0.62057022
93MP0000631_abnormal_neuroendocrine_gland0.61274718
94MP0001986_abnormal_taste_sensitivity0.61205766
95MP0005551_abnormal_eye_electrophysiolog0.60699707
96MP0002638_abnormal_pupillary_reflex0.58709752
97MP0005409_darkened_coat_color0.57491927
98MP0003123_paternal_imprinting0.55695667
99MP0003861_abnormal_nervous_system0.55597013
100MP0001485_abnormal_pinna_reflex0.55365868
101MP0002752_abnormal_somatic_nervous0.55358783
102MP0004742_abnormal_vestibular_system0.55128370
103MP0001943_abnormal_respiration0.55097788
104MP0002653_abnormal_ependyma_morphology0.54259301
105MP0003137_abnormal_impulse_conducting0.54162959
106MP0005166_decreased_susceptibility_to0.53436726
107MP0004130_abnormal_muscle_cell0.52251344
108MP0010769_abnormal_survival0.51892804
109MP0001299_abnormal_eye_distance/0.49720409
110MP0001765_abnormal_ion_homeostasis0.49712758
111MP0010770_preweaning_lethality0.49183079
112MP0002082_postnatal_lethality0.49183079
113MP0010768_mortality/aging0.49126167
114MP0003121_genomic_imprinting0.48498934
115MP0000026_abnormal_inner_ear0.47996908
116MP0003956_abnormal_body_size0.46729400
117MP0002873_normal_phenotype0.43529283
118MP0002249_abnormal_larynx_morphology0.42621374
119MP0003938_abnormal_ear_development0.42275599

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.07604157
2Myokymia (HP:0002411)7.21536989
3Focal seizures (HP:0007359)6.03031824
4Visual hallucinations (HP:0002367)5.42905709
5Epileptic encephalopathy (HP:0200134)5.27420736
6Atonic seizures (HP:0010819)4.89626796
7Febrile seizures (HP:0002373)4.48453972
8Absence seizures (HP:0002121)4.28396240
9Progressive cerebellar ataxia (HP:0002073)4.05237023
10Generalized tonic-clonic seizures (HP:0002069)4.03357651
11Dialeptic seizures (HP:0011146)3.92236728
12Poor eye contact (HP:0000817)3.76970026
13Impaired vibration sensation in the lower limbs (HP:0002166)3.71252538
14Broad-based gait (HP:0002136)3.67501563
15Papilledema (HP:0001085)3.62391673
16Ankle clonus (HP:0011448)3.59558059
17Impaired social interactions (HP:0000735)3.41018665
18Abnormal social behavior (HP:0012433)3.41018665
19Action tremor (HP:0002345)3.40540280
20Urinary bladder sphincter dysfunction (HP:0002839)3.36865090
21Gaze-evoked nystagmus (HP:0000640)3.34454840
22Depression (HP:0000716)3.26034116
23Akinesia (HP:0002304)3.23995450
24Tetraplegia (HP:0002445)3.19900953
25Supranuclear gaze palsy (HP:0000605)3.19409369
26Hyperventilation (HP:0002883)3.16629467
27Amblyopia (HP:0000646)3.13117033
28Postural instability (HP:0002172)3.03719624
29Dysdiadochokinesis (HP:0002075)3.01160729
30Dysmetria (HP:0001310)3.00607982
31Abnormality of the lower motor neuron (HP:0002366)2.98367955
32Apathy (HP:0000741)2.97502686
33Mutism (HP:0002300)2.96733367
34Abnormal eating behavior (HP:0100738)2.95403109
35Anxiety (HP:0000739)2.92207649
36Urinary urgency (HP:0000012)2.89794476
37Cerebral hypomyelination (HP:0006808)2.87005418
38Truncal ataxia (HP:0002078)2.82414587
39Genetic anticipation (HP:0003743)2.77646446
40Impaired smooth pursuit (HP:0007772)2.74533582
41Torticollis (HP:0000473)2.73804847
42Diminished motivation (HP:0000745)2.69923334
43Epileptiform EEG discharges (HP:0011182)2.67799162
44Progressive inability to walk (HP:0002505)2.63679875
45Drooling (HP:0002307)2.58940206
46Excessive salivation (HP:0003781)2.58940206
47Stereotypic behavior (HP:0000733)2.58462796
48Fetal akinesia sequence (HP:0001989)2.56918208
49Focal dystonia (HP:0004373)2.55330032
50Spastic gait (HP:0002064)2.54770484
51Bradykinesia (HP:0002067)2.53860956
52EEG with generalized epileptiform discharges (HP:0011198)2.49957109
53Impaired vibratory sensation (HP:0002495)2.49527984
54Ventricular fibrillation (HP:0001663)2.41264852
55Diplopia (HP:0000651)2.40805774
56Abnormality of binocular vision (HP:0011514)2.40805774
57Hypsarrhythmia (HP:0002521)2.40188596
58Peripheral hypomyelination (HP:0007182)2.39557187
59Termporal pattern (HP:0011008)2.38010295
60Insidious onset (HP:0003587)2.38010295
61Hemiplegia (HP:0002301)2.37813061
62Dysmetric saccades (HP:0000641)2.34610190
63Inability to walk (HP:0002540)2.32544458
64Absent speech (HP:0001344)2.31995086
65Abnormality of ocular smooth pursuit (HP:0000617)2.29880491
66Status epilepticus (HP:0002133)2.28724623
67Spastic tetraparesis (HP:0001285)2.27910534
68Split foot (HP:0001839)2.27752379
69Scanning speech (HP:0002168)2.27602480
70Resting tremor (HP:0002322)2.26899414
71Megalencephaly (HP:0001355)2.26575161
72Annular pancreas (HP:0001734)2.25903878
73Hyperacusis (HP:0010780)2.25761257
74Hemiparesis (HP:0001269)2.25125314
75Intention tremor (HP:0002080)2.24032885
76Craniofacial dystonia (HP:0012179)2.23467659
77Cerebral inclusion bodies (HP:0100314)2.23134555
78Lower limb amyotrophy (HP:0007210)2.22996210
79Lower limb muscle weakness (HP:0007340)2.20509810
80Bundle branch block (HP:0011710)2.20349285
81Neurofibrillary tangles (HP:0002185)2.17435446
82Obstructive sleep apnea (HP:0002870)2.15004065
83Generalized myoclonic seizures (HP:0002123)2.14680508
84Polyphagia (HP:0002591)2.09569178
85Upper limb amyotrophy (HP:0009129)2.08974055
86Distal upper limb amyotrophy (HP:0007149)2.08974055
87Pointed chin (HP:0000307)2.08856813
88Ankyloglossia (HP:0010296)2.08417569
89Turricephaly (HP:0000262)2.08220339
90Overriding aorta (HP:0002623)2.05851670
91Incomplete penetrance (HP:0003829)1.99125366
92Hand muscle atrophy (HP:0009130)1.96825204
93Abnormality of the corticospinal tract (HP:0002492)1.96360030
94Aplasia involving bones of the upper limbs (HP:0009823)1.96290286
95Aplasia of the phalanges of the hand (HP:0009802)1.96290286
96Aplasia involving bones of the extremities (HP:0009825)1.96290286
97Elfin facies (HP:0004428)1.93989461
98Dementia (HP:0000726)1.93898221
99Bronchomalacia (HP:0002780)1.93489600
100Pheochromocytoma (HP:0002666)1.92984176
101Rapidly progressive (HP:0003678)1.92966016
102Morphological abnormality of the pyramidal tract (HP:0002062)1.90719685
103Blue irides (HP:0000635)1.90315271
104Clonus (HP:0002169)1.90144812
105Spinal canal stenosis (HP:0003416)1.89408383
106Gait ataxia (HP:0002066)1.87256662
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86906807
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.85597037
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85597037
110Agitation (HP:0000713)1.85187465
111Delusions (HP:0000746)1.85138889
112Choreoathetosis (HP:0001266)1.84279484
113Intellectual disability, profound (HP:0002187)1.80896610
114Insomnia (HP:0100785)1.80481619
115Limb dystonia (HP:0002451)1.80157903
116Neuronal loss in central nervous system (HP:0002529)1.77498878
117Inappropriate behavior (HP:0000719)1.77315263
118Rigidity (HP:0002063)1.77301476
119CNS hypomyelination (HP:0003429)1.75735713
120Abnormality of salivation (HP:0100755)1.75125465
121Abnormal EKG (HP:0003115)1.75000742
122Lower limb asymmetry (HP:0100559)1.74154007
123Abnormality of the periventricular white matter (HP:0002518)1.74051835
124Protruding tongue (HP:0010808)1.73838405
125Sleep apnea (HP:0010535)1.73823364
126Increased circulating renin level (HP:0000848)1.72603370
127Hyperthyroidism (HP:0000836)1.71164141
128Heterochromia iridis (HP:0001100)1.64838222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.80849783
2NTRK34.67116690
3MAP3K94.15484412
4DAPK23.22136513
5MAP3K42.83397358
6MARK12.77529244
7MINK12.51424242
8MAP2K72.40714454
9PAK62.39122187
10KSR22.35665429
11PRKD32.21582054
12DAPK12.01443866
13MAP3K121.99622786
14NTRK21.90354129
15CAMKK11.88845175
16RIPK41.86917992
17MAP2K41.86276145
18NTRK11.81095801
19KSR11.68364872
20PLK21.59447652
21CDK191.59204279
22CDK51.58329208
23CASK1.57142658
24MAP3K21.48610470
25ARAF1.38423428
26PRPF4B1.35079355
27SIK21.29577586
28GRK51.27479568
29TYRO31.24077788
30TAOK11.23830101
31MAP3K131.23512080
32STK381.23072339
33TNIK1.18604843
34PRKCG1.18262806
35MAPK131.17040894
36FES1.09729001
37UHMK11.07706085
38LATS21.03421777
39CAMK11.02595466
40CCNB11.01349039
41TESK11.00451030
42RAF10.99890993
43PNCK0.95707544
44CAMKK20.95006817
45CDK180.94416016
46LIMK10.94404176
47CDK150.93980325
48STK110.92740007
49MAP3K110.89628984
50CAMK2A0.89065841
51CDK140.87290491
52PRKCH0.85032178
53MARK20.84044311
54CDK11A0.81409251
55ALK0.80943988
56PAK30.80391130
57OXSR10.79626806
58RET0.76603430
59CAMK2B0.74570859
60PDK10.73771835
61PHKG20.72688400
62PHKG10.72688400
63PKN10.71989469
64PTK2B0.70344263
65CSNK1G20.69976716
66PINK10.69433145
67SGK10.68530663
68SGK2230.68011115
69SGK4940.68011115
70PDPK10.67670648
71MAP3K10.66752675
72BMPR20.65575619
73DAPK30.65343253
74DMPK0.63169241
75SCYL20.61886379
76ROCK20.57915472
77SGK30.57625962
78SGK20.57476849
79NEK10.56239944
80MAP2K10.55906473
81DYRK1A0.49423291
82CAMK2D0.48889532
83AKT30.48767447
84TRIB30.48740696
85RPS6KA30.48026164
86TNK20.47350390
87LMTK20.46664659
88BRSK10.46131261
89MAP3K60.45676418
90PRKCE0.45134040
91MAP3K70.44558650
92NME10.42981650
93CDC42BPA0.42442338
94FYN0.42345808
95PRKCZ0.41810647
96CAMK2G0.41365959
97PRKG20.40783798
98FER0.40217248
99CAMK40.39555559
100ROCK10.39305828
101BRAF0.37482839
102ERBB20.37028135
103PDK40.35414812
104PDK30.35414812
105NEK60.35091775
106MAPK120.34992461
107RIPK10.34616194
108MAPK100.34328674
109MOS0.32331677
110CAMK1G0.30843039
111IRAK20.30545151
112PRKCA0.30227611
113PTK20.29817780
114MAPK80.28678978
115PDGFRA0.27727356
116SRC0.25339250
117CSNK1D0.23772736

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46217276
2Synaptic vesicle cycle_Homo sapiens_hsa047213.41906600
3Olfactory transduction_Homo sapiens_hsa047402.90489405
4Circadian entrainment_Homo sapiens_hsa047132.73073945
5Long-term potentiation_Homo sapiens_hsa047202.67633936
6GABAergic synapse_Homo sapiens_hsa047272.61198484
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60163614
8Glutamatergic synapse_Homo sapiens_hsa047242.53504844
9Morphine addiction_Homo sapiens_hsa050322.49245051
10Amphetamine addiction_Homo sapiens_hsa050312.48646196
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28228793
12Salivary secretion_Homo sapiens_hsa049702.20417314
13Dopaminergic synapse_Homo sapiens_hsa047282.11346399
14Insulin secretion_Homo sapiens_hsa049112.10192522
15Gastric acid secretion_Homo sapiens_hsa049711.99074192
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94121114
17Cholinergic synapse_Homo sapiens_hsa047251.92806616
18Oxytocin signaling pathway_Homo sapiens_hsa049211.76569575
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70962294
20Renin secretion_Homo sapiens_hsa049241.67743235
21Long-term depression_Homo sapiens_hsa047301.67628397
22Cocaine addiction_Homo sapiens_hsa050301.62555086
23Vitamin B6 metabolism_Homo sapiens_hsa007501.62540702
24Calcium signaling pathway_Homo sapiens_hsa040201.57787733
25Taste transduction_Homo sapiens_hsa047421.56491359
26Collecting duct acid secretion_Homo sapiens_hsa049661.54425185
27Serotonergic synapse_Homo sapiens_hsa047261.51112211
28GnRH signaling pathway_Homo sapiens_hsa049121.48665464
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45540669
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45192049
31Gap junction_Homo sapiens_hsa045401.35341404
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33345453
33cAMP signaling pathway_Homo sapiens_hsa040241.26652229
34Glioma_Homo sapiens_hsa052141.25236039
35Estrogen signaling pathway_Homo sapiens_hsa049151.19958227
36Type II diabetes mellitus_Homo sapiens_hsa049301.18018186
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12883455
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10645764
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09214271
40Melanogenesis_Homo sapiens_hsa049161.07286213
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06130452
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.05384594
43ErbB signaling pathway_Homo sapiens_hsa040121.04851575
44Axon guidance_Homo sapiens_hsa043601.02473060
45Vibrio cholerae infection_Homo sapiens_hsa051101.01889533
46Nitrogen metabolism_Homo sapiens_hsa009101.01022372
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95033492
48Oocyte meiosis_Homo sapiens_hsa041140.90343208
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86606734
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86034587
51Dilated cardiomyopathy_Homo sapiens_hsa054140.84099889
52Cardiac muscle contraction_Homo sapiens_hsa042600.83815457
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.82385665
54Thyroid hormone synthesis_Homo sapiens_hsa049180.81358395
55Pancreatic secretion_Homo sapiens_hsa049720.79320179
56Dorso-ventral axis formation_Homo sapiens_hsa043200.78513061
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75963511
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75611068
59MAPK signaling pathway_Homo sapiens_hsa040100.70460943
60VEGF signaling pathway_Homo sapiens_hsa043700.68427130
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.64980571
62Choline metabolism in cancer_Homo sapiens_hsa052310.63642804
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62117036
64Glucagon signaling pathway_Homo sapiens_hsa049220.61760801
65Type I diabetes mellitus_Homo sapiens_hsa049400.60866160
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60469328
67Rap1 signaling pathway_Homo sapiens_hsa040150.59234801
68mTOR signaling pathway_Homo sapiens_hsa041500.58684317
69Ras signaling pathway_Homo sapiens_hsa040140.57846546
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55115503
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53113654
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51991011
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.51597310
74Endocytosis_Homo sapiens_hsa041440.51582661
75Circadian rhythm_Homo sapiens_hsa047100.50813875
76Phototransduction_Homo sapiens_hsa047440.49821754
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48467072
78Bile secretion_Homo sapiens_hsa049760.48426055
79Inositol phosphate metabolism_Homo sapiens_hsa005620.48308160
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45205278
81Prion diseases_Homo sapiens_hsa050200.45175711
82Non-small cell lung cancer_Homo sapiens_hsa052230.44872945
83Alcoholism_Homo sapiens_hsa050340.44463070
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43950641
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43915068
86Endometrial cancer_Homo sapiens_hsa052130.43851912
87Insulin signaling pathway_Homo sapiens_hsa049100.42473510
88Renal cell carcinoma_Homo sapiens_hsa052110.42241131
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42226478
90Wnt signaling pathway_Homo sapiens_hsa043100.40110656
91Ovarian steroidogenesis_Homo sapiens_hsa049130.38694141
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38538025
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37388637
94Tight junction_Homo sapiens_hsa045300.37316052
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36523701
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36420276
97Hippo signaling pathway_Homo sapiens_hsa043900.34748304
98Chemokine signaling pathway_Homo sapiens_hsa040620.33729163
99Arginine and proline metabolism_Homo sapiens_hsa003300.32205747
100African trypanosomiasis_Homo sapiens_hsa051430.32049377
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30712735
102Arginine biosynthesis_Homo sapiens_hsa002200.30367936
103AMPK signaling pathway_Homo sapiens_hsa041520.29774764
104Platelet activation_Homo sapiens_hsa046110.29430409
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29031112
106HIF-1 signaling pathway_Homo sapiens_hsa040660.28941553
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28744950
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28634976
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25000548
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24145790

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