KCNG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.83171152
2cardiac myofibril assembly (GO:0055003)8.81419659
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.94123138
4myofibril assembly (GO:0030239)7.53201129
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.45780792
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.24389037
7cardiac muscle contraction (GO:0060048)6.87974604
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.68434674
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.58411984
10regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.50685076
11cardiac muscle cell development (GO:0055013)6.40443134
12regulation of actin filament-based movement (GO:1903115)6.39178227
13tricarboxylic acid cycle (GO:0006099)6.32477814
14ventricular cardiac muscle cell action potential (GO:0086005)6.13872204
15cardiac cell development (GO:0055006)5.99448048
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.96124065
17ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.83489856
18adult heart development (GO:0007512)5.81801313
19muscle filament sliding (GO:0030049)5.81482026
20actin-myosin filament sliding (GO:0033275)5.81482026
21bundle of His cell to Purkinje myocyte communication (GO:0086069)5.73943171
22cardiac muscle tissue morphogenesis (GO:0055008)5.70769923
23regulation of relaxation of muscle (GO:1901077)5.65572516
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.63752965
25heart trabecula formation (GO:0060347)5.50885912
26regulation of sarcomere organization (GO:0060297)5.49387306
27cardiac muscle hypertrophy (GO:0003300)5.47890575
28actomyosin structure organization (GO:0031032)5.46786968
29plasma membrane repair (GO:0001778)5.46377334
30cell communication involved in cardiac conduction (GO:0086065)5.22574037
31striated muscle hypertrophy (GO:0014897)5.17149353
32regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.16446023
33regulation of striated muscle contraction (GO:0006942)5.14512714
34regulation of the force of heart contraction (GO:0002026)5.10174499
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.08842907
36regulation of membrane repolarization (GO:0060306)5.07535671
37muscle tissue morphogenesis (GO:0060415)5.04804783
38striated muscle contraction (GO:0006941)4.98645004
39regulation of response to osmotic stress (GO:0047484)4.94939154
40regulation of cell communication by electrical coupling (GO:0010649)4.90231728
41cell communication by electrical coupling (GO:0010644)4.89573836
42heart contraction (GO:0060047)4.87887059
43heart process (GO:0003015)4.87887059
44regulation of cardiac muscle cell contraction (GO:0086004)4.81811280
45regulation of skeletal muscle contraction (GO:0014819)4.77135675
46actin-mediated cell contraction (GO:0070252)4.76142677
47regulation of acyl-CoA biosynthetic process (GO:0050812)4.74934668
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.74069406
49carnitine shuttle (GO:0006853)4.73060027
50regulation of cardiac muscle contraction (GO:0055117)4.62437349
51muscle hypertrophy (GO:0014896)4.55263423
52negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.44673333
53energy coupled proton transport, down electrochemical gradient (GO:0015985)4.43584808
54ATP synthesis coupled proton transport (GO:0015986)4.43584808
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.38929005
56regulation of cofactor metabolic process (GO:0051193)4.34810820
57regulation of coenzyme metabolic process (GO:0051196)4.34810820
58complement activation, alternative pathway (GO:0006957)4.33300661
59negative regulation of potassium ion transport (GO:0043267)4.32986674
60sarcoplasmic reticulum calcium ion transport (GO:0070296)4.30262535
61cardiac muscle cell action potential involved in contraction (GO:0086002)4.29387530
62hemoglobin metabolic process (GO:0020027)4.29146349
63relaxation of cardiac muscle (GO:0055119)4.27169886
64respiratory electron transport chain (GO:0022904)4.25782890
65regulation of heart rate (GO:0002027)4.25342813
66cardiac muscle cell action potential (GO:0086001)4.23796954
67positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.21312268
68regulation of cardioblast differentiation (GO:0051890)4.18631205
69electron transport chain (GO:0022900)4.12845921
70fatty acid transmembrane transport (GO:1902001)4.04210131
71negative regulation of striated muscle cell apoptotic process (GO:0010664)4.02129349
72negative regulation of protein localization to cell surface (GO:2000009)4.02067332
73oxidative phosphorylation (GO:0006119)4.00917938
74cardiac muscle adaptation (GO:0014887)3.99006610
75cardiac muscle hypertrophy in response to stress (GO:0014898)3.99006610
76muscle hypertrophy in response to stress (GO:0003299)3.99006610
77ventricular cardiac muscle cell development (GO:0055015)3.94210836
78protein carboxylation (GO:0018214)3.93509574
79peptidyl-glutamic acid carboxylation (GO:0017187)3.93509574
80potassium ion export (GO:0071435)3.90147338
81* regulation of heart contraction (GO:0008016)3.89679097
82cardiac conduction (GO:0061337)3.89483728
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.85316627
84negative regulation of fibrinolysis (GO:0051918)3.84354682
85NADH metabolic process (GO:0006734)3.83934474
86regulation of ATPase activity (GO:0043462)3.83188225
87regulation of ATP catabolic process (GO:1903289)3.83188225
88response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.82811205
89regulation of heart rate by cardiac conduction (GO:0086091)3.80113620
90urea cycle (GO:0000050)3.76261782
91urea metabolic process (GO:0019627)3.71864023
92regulation of triglyceride catabolic process (GO:0010896)3.71220422
93oxygen transport (GO:0015671)3.69195686
94negative regulation of cholesterol transport (GO:0032375)3.67709074
95negative regulation of sterol transport (GO:0032372)3.67709074
96positive regulation of cation channel activity (GO:2001259)3.66105407
972-oxoglutarate metabolic process (GO:0006103)3.59816583
98positive regulation of heart contraction (GO:0045823)3.59077092
99activation of MAPKKK activity (GO:0000185)3.56139929
100actin filament-based movement (GO:0030048)3.56092855
101regulation of calcium ion transmembrane transporter activity (GO:1901019)3.56085704
102regulation of calcium ion transmembrane transport (GO:1903169)3.56085704
103regulation of fibrinolysis (GO:0051917)3.53914398
104regulation of sulfur metabolic process (GO:0042762)3.52353847
105positive regulation of heart rate (GO:0010460)3.51905779
106positive regulation of potassium ion transmembrane transport (GO:1901381)3.49857150
107detection of calcium ion (GO:0005513)3.49546342
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48629347
109striated muscle cell development (GO:0055002)3.48072360
110membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.47228407
111trabecula formation (GO:0060343)3.45847763
112germinal center formation (GO:0002467)3.45626563
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.45576023
114carnitine transmembrane transport (GO:1902603)3.43964200
115nitrogen cycle metabolic process (GO:0071941)3.41571009
116regulation of striated muscle cell apoptotic process (GO:0010662)3.36533341
117mannose metabolic process (GO:0006013)3.35726238
118embryonic camera-type eye morphogenesis (GO:0048596)3.28835389
119negative regulation of lipid transport (GO:0032369)3.28329784
120positive regulation of triglyceride lipase activity (GO:0061365)3.28006606
121positive regulation of lipoprotein lipase activity (GO:0051006)3.28006606
122positive regulation of lipid catabolic process (GO:0050996)3.27889825
123positive regulation of fatty acid beta-oxidation (GO:0032000)3.23216922
124positive regulation of fatty acid biosynthetic process (GO:0045723)3.18649191
125negative regulation of fatty acid transport (GO:2000192)3.17706135
126regulation of hypersensitivity (GO:0002883)3.16015798
127regulation of fatty acid beta-oxidation (GO:0031998)3.14717640
128receptor recycling (GO:0001881)3.11461598
129negative regulation of erythrocyte differentiation (GO:0045647)3.08872542
130response to muramyl dipeptide (GO:0032495)3.07515038
131antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07488963
132phospholipid efflux (GO:0033700)3.00295113
133regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99702971
134positive regulation of blood coagulation (GO:0030194)2.95387466
135positive regulation of hemostasis (GO:1900048)2.95387466
136tooth mineralization (GO:0034505)2.89909938
137positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.89728978
138NIK/NF-kappaB signaling (GO:0038061)2.84560471
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81101001
140regulation of female gonad development (GO:2000194)2.79661293
141response to methylmercury (GO:0051597)2.76039424
142detection of molecule of bacterial origin (GO:0032490)2.73268541
143alkaloid metabolic process (GO:0009820)2.72935095
144regulation of protein activation cascade (GO:2000257)2.72359535
145positive regulation of coagulation (GO:0050820)2.68029865
146regulation of complement activation (GO:0030449)2.66535753
147positive regulation of triglyceride metabolic process (GO:0090208)2.63693173
148positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61637047
149detection of external biotic stimulus (GO:0098581)2.59730556
150chondroitin sulfate biosynthetic process (GO:0030206)2.59004443
151regulation of p38MAPK cascade (GO:1900744)2.57298430
152fibrinolysis (GO:0042730)2.56781887
153cellular hyperosmotic response (GO:0071474)2.55758813
154regulation of fatty acid biosynthetic process (GO:0042304)2.55498825
155regulation of leukocyte degranulation (GO:0043300)2.55052864
156basement membrane organization (GO:0071711)2.54293971
157protein-lipid complex remodeling (GO:0034368)2.53495969
158macromolecular complex remodeling (GO:0034367)2.53495969
159plasma lipoprotein particle remodeling (GO:0034369)2.53495969
160regulation of protein polyubiquitination (GO:1902914)2.51530087
161detection of other organism (GO:0098543)2.50554046
162positive regulation of phagocytosis (GO:0050766)2.49459666
163imidazole-containing compound metabolic process (GO:0052803)2.46760756
164regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.46065730
165negative regulation of type 2 immune response (GO:0002829)2.45879443
166UV protection (GO:0009650)2.45731959
167embryonic eye morphogenesis (GO:0048048)2.44059830
168regulation of plasminogen activation (GO:0010755)2.42864535
169opsonization (GO:0008228)2.42268369
170antigen processing and presentation of endogenous antigen (GO:0019883)2.41860503
171L-phenylalanine catabolic process (GO:0006559)2.40765315
172erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.40765315
173glyoxylate metabolic process (GO:0046487)2.39876127
174positive regulation of fatty acid metabolic process (GO:0045923)2.39703526
175detection of bacterium (GO:0016045)2.39026016
176protein activation cascade (GO:0072376)2.38616995
177regulation of lipid catabolic process (GO:0050994)2.35653574
178macrophage activation involved in immune response (GO:0002281)2.35263374
179regulation of T-helper 2 cell differentiation (GO:0045628)2.34382512
180acute-phase response (GO:0006953)2.33550635
181regulation of interferon-beta biosynthetic process (GO:0045357)2.33370609
182complement activation (GO:0006956)2.32701341
183phosphate ion transmembrane transport (GO:0035435)2.30918986
184regulation of apoptotic cell clearance (GO:2000425)2.30456436
185regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.30266402
186regulation of glucose import in response to insulin stimulus (GO:2001273)2.30014134
187regulation of humoral immune response (GO:0002920)2.29268431
188positive regulation of humoral immune response (GO:0002922)2.28612889
189regulation of cholesterol storage (GO:0010885)2.27650624
190pinocytosis (GO:0006907)2.26595260
191complement activation, classical pathway (GO:0006958)2.26379124
192modulation by symbiont of host cellular process (GO:0044068)2.25879976
193regulation of mast cell degranulation (GO:0043304)2.25313545
194folic acid metabolic process (GO:0046655)2.24791554
195definitive hemopoiesis (GO:0060216)2.24400043
196regulation of phagocytosis (GO:0050764)2.22547706
197lipopolysaccharide-mediated signaling pathway (GO:0031663)2.22304654
198erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.22121665
199L-phenylalanine metabolic process (GO:0006558)2.22121665
200modulation by virus of host process (GO:0019054)2.22116353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.09881302
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.04007931
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.79791306
4VDR_21846776_ChIP-Seq_THP-1_Human3.98546888
5EZH2_22144423_ChIP-Seq_EOC_Human3.95842350
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.91401207
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.91401207
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60492071
9ZNF263_19887448_ChIP-Seq_K562_Human3.38143395
10MYC_22102868_ChIP-Seq_BL_Human3.35448744
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.28970766
12MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.08535358
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98991991
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.80642282
15VDR_24763502_ChIP-Seq_THP-1_Human2.72967250
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57022445
17TCF7_22412390_ChIP-Seq_EML_Mouse2.40333843
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32328859
19SCL_19346495_ChIP-Seq_HPC-7_Human2.28322951
20GATA4_21415370_ChIP-Seq_HL-1_Mouse2.27900130
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23752159
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.22438455
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14412414
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11382238
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09983395
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.09952703
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04425251
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96239782
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.91979173
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90380799
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.90141577
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.88748497
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88193236
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85554219
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77956117
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76321078
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75175115
38DROSHA_22980978_ChIP-Seq_HELA_Human1.73281767
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66282737
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.64786444
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64268025
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61880296
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60578260
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57318297
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56735247
46MAF_26560356_Chip-Seq_TH1_Human1.55832520
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.54864948
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.52381919
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52187801
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.47338024
51* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47335267
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.46811133
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.46652907
54UTX_26944678_Chip-Seq_JUKART_Human1.44741433
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.43232630
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.38823413
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38747553
58CTCF_27219007_Chip-Seq_Bcells_Human1.37184536
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35634842
60BCOR_27268052_Chip-Seq_Bcells_Human1.34555006
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.34500202
62MAF_26560356_Chip-Seq_TH2_Human1.34435510
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33238156
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31985805
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31611385
66KDM2B_26808549_Chip-Seq_DND41_Human1.31361344
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31161225
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30182345
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.30019856
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29836906
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29758344
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29758344
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29613474
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28264661
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24532828
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23034715
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.22664353
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.22447050
79CLOCK_20551151_ChIP-Seq_293T_Human1.21128289
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21113269
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21060730
82GATA1_19941826_ChIP-Seq_K562_Human1.20674257
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20417800
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18120126
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.16124888
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15350051
87* LXR_22292898_ChIP-Seq_THP-1_Human1.14504157
88CREB1_26743006_Chip-Seq_LNCaP_Human1.14499971
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14409310
90TP53_22127205_ChIP-Seq_IMR90_Human1.13026567
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.12805492
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12774422
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12191469
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.12034495
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11579163
96SMC4_20622854_ChIP-Seq_HELA_Human1.11023304
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10973723
98BCL6_27268052_Chip-Seq_Bcells_Human1.10476505
99ZNF274_21170338_ChIP-Seq_K562_Hela1.09788988
100* TP63_22573176_ChIP-Seq_HFKS_Human1.09331296
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.08451009
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08163751
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07346969
104NCOR1_26117541_ChIP-Seq_K562_Human1.06984152
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05200162
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05129276
107TRIM28_21343339_ChIP-Seq_HEK293_Human1.04339058
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03810237
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03579229
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.02783726
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02766068
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02204913
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.01229105
114PHF8_20622854_ChIP-Seq_HELA_Human1.01125008
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00982350
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00773572
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00184466
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.99777454
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99603868
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99298958
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.98959294
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98690713
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98587325
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98576535
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97187748
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95457418
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94808631
128E2F1_20622854_ChIP-Seq_HELA_Human0.94697042
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94667493
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94609068
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94554030
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94517909
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94515013
134SPI1_20517297_ChIP-Seq_HL60_Human0.92612166
135KDM2B_26808549_Chip-Seq_K562_Human0.92386412
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.91221359
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91185183
138RACK7_27058665_Chip-Seq_MCF-7_Human0.90404505
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.89819511
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89431161
141SPI1_23127762_ChIP-Seq_K562_Human0.88652565
142GATA1_22025678_ChIP-Seq_K562_Human0.88203234
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87630102
144P68_20966046_ChIP-Seq_HELA_Human0.87562244
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87241981
146DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87058859
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86168963
148GATA2_19941826_ChIP-Seq_K562_Human0.85997152
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85488441
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85454484
151GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83930726
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82578582
153TP53_23651856_ChIP-Seq_MEFs_Mouse0.81871835
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81870323
155* SOX2_21211035_ChIP-Seq_LN229_Gbm0.81180226
156BCAT_22108803_ChIP-Seq_LS180_Human0.80022293
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79169339
158SUZ12_27294783_Chip-Seq_ESCs_Mouse0.78854569
159ATF3_27146783_Chip-Seq_COLON_Human0.78430294
160JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78331288
161FOXA2_19822575_ChIP-Seq_HepG2_Human0.78184741
162SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.76159503
163OCT4_20526341_ChIP-Seq_ESCs_Human0.76110360
164RNF2_27304074_Chip-Seq_ESCs_Mouse0.75086535
165SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74737530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.00595607
2MP0004084_abnormal_cardiac_muscle6.11368124
3MP0003646_muscle_fatigue5.42432985
4MP0004215_abnormal_myocardial_fiber5.21506033
5MP0000751_myopathy5.11709643
6MP0004036_abnormal_muscle_relaxation4.33772044
7MP0005330_cardiomyopathy4.04045057
8MP0002139_abnormal_hepatobiliary_system3.97762449
9MP0000749_muscle_degeneration3.44816702
10MP0002972_abnormal_cardiac_muscle3.31319432
11MP0003137_abnormal_impulse_conducting3.26112274
12MP0008775_abnormal_heart_ventricle3.10748011
13MP0005360_urolithiasis3.07859025
14MP0002396_abnormal_hematopoietic_system3.04841363
15MP0004087_abnormal_muscle_fiber2.94464910
16MP0009840_abnormal_foam_cell2.87271654
17MP0005385_cardiovascular_system_phenoty2.75244282
18MP0001544_abnormal_cardiovascular_syste2.75244282
19MP0005058_abnormal_lysosome_morphology2.74019114
20MP0005076_abnormal_cell_differentiation2.70392639
21MP0010630_abnormal_cardiac_muscle2.66721796
22MP0005620_abnormal_muscle_contractility2.64209212
23MP0006138_congestive_heart_failure2.62697843
24MP0004484_altered_response_of2.60230540
25MP0003191_abnormal_cellular_cholesterol2.54792372
26MP0000750_abnormal_muscle_regeneration2.50891267
27MP0003828_pulmonary_edema2.42299150
28MP0004085_abnormal_heartbeat2.38183285
29MP0004130_abnormal_muscle_cell2.31529172
30MP0002106_abnormal_muscle_physiology2.30883903
31MP0002138_abnormal_hepatobiliary_system2.24837884
32MP0003091_abnormal_cell_migration2.15223035
33MP0005409_darkened_coat_color2.08295387
34MP0002269_muscular_atrophy2.06544332
35MP0003436_decreased_susceptibility_to2.06408178
36MP0004510_myositis1.97355635
37MP0003172_abnormal_lysosome_physiology1.95690981
38MP0000685_abnormal_immune_system1.95226909
39MP0003221_abnormal_cardiomyocyte_apopto1.94595083
40MP0003303_peritoneal_inflammation1.90796503
41MP0004381_abnormal_hair_follicle1.90333674
42MP0009278_abnormal_bone_marrow1.85050128
43MP0005369_muscle_phenotype1.84609463
44MP0008875_abnormal_xenobiotic_pharmacok1.83647883
45MP0004145_abnormal_muscle_electrophysio1.82270193
46MP0005365_abnormal_bile_salt1.73150230
47MP0002127_abnormal_cardiovascular_syste1.72851819
48MP0001986_abnormal_taste_sensitivity1.71421369
49MP0000747_muscle_weakness1.71242647
50MP0001545_abnormal_hematopoietic_system1.71198808
51MP0005397_hematopoietic_system_phenotyp1.71198808
52MP0006036_abnormal_mitochondrial_physio1.69616094
53MP0000759_abnormal_skeletal_muscle1.69450936
54MP0004233_abnormal_muscle_weight1.61672756
55MP0002089_abnormal_postnatal_growth/wei1.57163032
56MP0001835_abnormal_antigen_presentation1.56039249
57MP0003183_abnormal_peptide_metabolism1.52442906
58MP0004858_abnormal_nervous_system1.50170897
59MP0002419_abnormal_innate_immunity1.44160395
60MP0004808_abnormal_hematopoietic_stem1.42892176
61MP0003950_abnormal_plasma_membrane1.42467961
62MP0005085_abnormal_gallbladder_physiolo1.40252230
63MP0001851_eye_inflammation1.38412535
64MP0008260_abnormal_autophagy1.38327327
65MP0003300_gastrointestinal_ulcer1.37880163
66MP0003567_abnormal_fetal_cardiomyocyte1.37104596
67MP0003195_calcinosis1.30875921
68MP0005464_abnormal_platelet_physiology1.30767006
69MP0005666_abnormal_adipose_tissue1.27474913
70MP0002332_abnormal_exercise_endurance1.26098296
71MP0010329_abnormal_lipoprotein_level1.24529734
72MP0002234_abnormal_pharynx_morphology1.22436098
73MP0005165_increased_susceptibility_to1.21800617
74MP0000604_amyloidosis1.20756918
75MP0000343_altered_response_to1.20501839
76MP0010368_abnormal_lymphatic_system1.20092504
77MP0005025_abnormal_response_to1.19392637
78MP0003879_abnormal_hair_cell1.17535707
79MP0000266_abnormal_heart_morphology1.17316204
80MP0003279_aneurysm1.15281707
81MP0010155_abnormal_intestine_physiology1.15250803
82MP0005670_abnormal_white_adipose1.13980913
83MP0002998_abnormal_bone_remodeling1.12366419
84MP0005171_absent_coat_pigmentation1.08169524
85MP0002405_respiratory_system_inflammati1.06391429
86MP0004947_skin_inflammation1.06149199
87MP0005387_immune_system_phenotype1.04634680
88MP0001790_abnormal_immune_system1.04634680
89MP0002877_abnormal_melanocyte_morpholog1.01823545
90MP0006035_abnormal_mitochondrial_morpho1.01600666
91MP0005000_abnormal_immune_tolerance0.99679931
92MP0000609_abnormal_liver_physiology0.99562717
93MP0005023_abnormal_wound_healing0.99373361
94MP0002398_abnormal_bone_marrow0.96329169
95MP0003075_altered_response_to0.94774591
96MP0008004_abnormal_stomach_pH0.94222626
97MP0001958_emphysema0.94063399
98MP0002420_abnormal_adaptive_immunity0.93143896
99MP0001542_abnormal_bone_strength0.93111692
100MP0005623_abnormal_meninges_morphology0.92309883
101MP0003763_abnormal_thymus_physiology0.91563223
102MP0000858_altered_metastatic_potential0.91519694
103MP0001915_intracranial_hemorrhage0.90388489
104MP0001819_abnormal_immune_cell0.89893583
105MP0003283_abnormal_digestive_organ0.89085204
106MP0009764_decreased_sensitivity_to0.88113491
107MP0000716_abnormal_immune_system0.87595815
108MP0000230_abnormal_systemic_arterial0.87275096
109MP0002722_abnormal_immune_system0.86417368
110MP0008469_abnormal_protein_level0.85795987
111MP0003329_amyloid_beta_deposits0.85337292
112MP0002060_abnormal_skin_morphology0.83376121
113MP0001853_heart_inflammation0.83190348
114MP0001800_abnormal_humoral_immune0.82260751
115MP0009765_abnormal_xenobiotic_induced0.82099434
116MP0002723_abnormal_immune_serum0.82027387
117MP0002128_abnormal_blood_circulation0.81621003
118MP0000015_abnormal_ear_pigmentation0.81181637
119MP0005375_adipose_tissue_phenotype0.80745725
120MP0002452_abnormal_antigen_presenting0.80383440
121MP0001661_extended_life_span0.80368547
122MP0002166_altered_tumor_susceptibility0.80051994
123MP0009333_abnormal_splenocyte_physiolog0.79018686
124MP0005164_abnormal_response_to0.78646073
125MP0003453_abnormal_keratinocyte_physiol0.78610245
126MP0002909_abnormal_adrenal_gland0.78179416
127MP0004185_abnormal_adipocyte_glucose0.78010836
128MP0002933_joint_inflammation0.77279958
129MP0000703_abnormal_thymus_morphology0.76947489
130MP0005166_decreased_susceptibility_to0.76592843
131MP0001533_abnormal_skeleton_physiology0.76398073
132MP0000465_gastrointestinal_hemorrhage0.76090163
133MP0002249_abnormal_larynx_morphology0.75436796
134MP0002429_abnormal_blood_cell0.75072205
135MP0005266_abnormal_metabolism0.72107406
136MP0003566_abnormal_cell_adhesion0.69876725
137MP0004147_increased_porphyrin_level0.68361601
138MP0005451_abnormal_body_composition0.62411083
139MP0001879_abnormal_lymphatic_vessel0.61087224
140MP0002108_abnormal_muscle_morphology0.60785456
141MP0004043_abnormal_pH_regulation0.59303332
142MP0000767_abnormal_smooth_muscle0.55329402
143MP0004272_abnormal_basement_membrane0.54780244
144MP0005187_abnormal_penis_morphology0.52483217
145MP0005386_behavior/neurological_phenoty0.47216222
146MP0004924_abnormal_behavior0.47216222
147MP0004859_abnormal_synaptic_plasticity0.45254764
148MP0002925_abnormal_cardiovascular_devel0.45092392
149MP0005319_abnormal_enzyme/_coenzyme0.43869551
150MP0005535_abnormal_body_temperature0.42128554
151MP0000013_abnormal_adipose_tissue0.41869732
152MP0002822_catalepsy0.41842396
153MP0002078_abnormal_glucose_homeostasis0.41430712
154MP0000003_abnormal_adipose_tissue0.40627525
155MP0009384_cardiac_valve_regurgitation0.39419478
156MP0005595_abnormal_vascular_smooth0.39392459
157MP0001784_abnormal_fluid_regulation0.38684172
158MP0003806_abnormal_nucleotide_metabolis0.38109239
159MP0005167_abnormal_blood-brain_barrier0.37692829
160MP0003878_abnormal_ear_physiology0.37548623
161MP0005377_hearing/vestibular/ear_phenot0.37548623
162MP0003705_abnormal_hypodermis_morpholog0.36800552
163MP0003984_embryonic_growth_retardation0.35439679
164MP0008961_abnormal_basal_metabolism0.35405584
165MP0002088_abnormal_embryonic_growth/wei0.34111741
166MP0001614_abnormal_blood_vessel0.33606901
167MP0002971_abnormal_brown_adipose0.31580886
168MP0000733_abnormal_muscle_development0.30712531
169MP0009780_abnormal_chondrocyte_physiolo0.30453975
170MP0003948_abnormal_gas_homeostasis0.30083784
171MP0002735_abnormal_chemical_nociception0.29259082
172MP0008874_decreased_physiological_sensi0.28727356
173MP0001727_abnormal_embryo_implantation0.28183001
174MP0008569_lethality_at_weaning0.27804417
175MP0002295_abnormal_pulmonary_circulatio0.26158984
176MP0008438_abnormal_cutaneous_collagen0.24579164
177MP0003656_abnormal_erythrocyte_physiolo0.22193090
178MP0002272_abnormal_nervous_system0.20067690
179MP0005388_respiratory_system_phenotype0.19610727
180MP0002133_abnormal_respiratory_system0.19610727
181MP0001485_abnormal_pinna_reflex0.19575033
182MP0003635_abnormal_synaptic_transmissio0.18453658
183MP0000249_abnormal_blood_vessel0.18220953

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.72123477
2Ventricular tachycardia (HP:0004756)7.20877297
3Atrial fibrillation (HP:0005110)6.63664680
4Primary atrial arrhythmia (HP:0001692)6.24329619
5Supraventricular tachycardia (HP:0004755)6.05278021
6Calf muscle hypertrophy (HP:0008981)5.94736621
7Supraventricular arrhythmia (HP:0005115)5.93717337
8Syncope (HP:0001279)5.56394234
9Lipoatrophy (HP:0100578)5.52944127
10Subaortic stenosis (HP:0001682)5.48008097
11Abnormality of the left ventricular outflow tract (HP:0011103)5.48008097
12Muscle hypertrophy of the lower extremities (HP:0008968)5.32771226
13Muscle fiber splitting (HP:0003555)5.25612977
14Abnormality of the calf musculature (HP:0001430)5.14204420
15Exercise-induced muscle cramps (HP:0003710)5.11873315
16Exercise-induced myalgia (HP:0003738)5.06481746
17Right ventricular cardiomyopathy (HP:0011663)5.03071946
18Prolonged QT interval (HP:0001657)4.93353992
19Bundle branch block (HP:0011710)4.92247199
20Palpitations (HP:0001962)4.83821696
21Dilated cardiomyopathy (HP:0001644)4.55402328
22Ventricular fibrillation (HP:0001663)4.54915157
23Deep venous thrombosis (HP:0002625)4.54231272
24Hyporeflexia of lower limbs (HP:0002600)4.53012365
25Ventricular arrhythmia (HP:0004308)4.48545994
26Myoglobinuria (HP:0002913)4.37620984
27Abnormality of monocarboxylic acid metabolism (HP:0010996)4.22659841
28Asymmetric septal hypertrophy (HP:0001670)4.13248756
29Heart block (HP:0012722)4.04524714
30Atrioventricular block (HP:0001678)3.97808177
31EMG: myopathic abnormalities (HP:0003458)3.83841067
32Abnormal atrioventricular conduction (HP:0005150)3.79584347
33Abnormal EKG (HP:0003115)3.68972117
34Complement deficiency (HP:0004431)3.54468764
35Joint hemorrhage (HP:0005261)3.52425627
36Abnormality of complement system (HP:0005339)3.50166036
37Increased connective tissue (HP:0009025)3.41854195
38Abnormal mitochondria in muscle tissue (HP:0008316)3.28241685
39Myotonia (HP:0002486)3.25660732
40Acute necrotizing encephalopathy (HP:0006965)3.25435213
41Rhabdomyolysis (HP:0003201)3.24983186
42Left ventricular hypertrophy (HP:0001712)3.21064994
43Hepatic necrosis (HP:0002605)3.20604951
44Abnormality of the fingertips (HP:0001211)3.10877217
45Axonal loss (HP:0003447)3.08963626
46Hemorrhage of the eye (HP:0011885)2.93216988
47Hepatocellular necrosis (HP:0001404)2.91431920
48Systemic lupus erythematosus (HP:0002725)2.91073047
49Difficulty running (HP:0009046)2.90898074
50Ketoacidosis (HP:0001993)2.76101704
51Acute encephalopathy (HP:0006846)2.75977836
52Mitochondrial inheritance (HP:0001427)2.74591177
53Ragged-red muscle fibers (HP:0003200)2.74116382
54Palmoplantar keratoderma (HP:0000982)2.73996952
55Difficulty climbing stairs (HP:0003551)2.72429403
56Progressive macrocephaly (HP:0004481)2.70056462
57Hyperlipoproteinemia (HP:0010980)2.68196385
58Mitral stenosis (HP:0001718)2.65030685
59Testicular atrophy (HP:0000029)2.56788551
60Prolonged partial thromboplastin time (HP:0003645)2.55834799
61Increased muscle lipid content (HP:0009058)2.55137768
62Increased CSF lactate (HP:0002490)2.54380837
63Ulnar bowing (HP:0003031)2.54341076
64Protrusio acetabuli (HP:0003179)2.54119552
65Hypoalphalipoproteinemia (HP:0003233)2.53468482
66Glomerulonephritis (HP:0000099)2.48765583
67Colitis (HP:0002583)2.46058895
68Hypoglycemic coma (HP:0001325)2.45421313
69Cerebral edema (HP:0002181)2.44396129
70Hypertriglyceridemia (HP:0002155)2.43321248
71Cerebral aneurysm (HP:0004944)2.41344005
72Conjunctival hamartoma (HP:0100780)2.40838595
73Cellulitis (HP:0100658)2.40314728
74Dysostosis multiplex (HP:0000943)2.38447050
75Sudden cardiac death (HP:0001645)2.37739504
76Asymmetry of the thorax (HP:0001555)2.36501502
77Abnormal platelet function (HP:0011869)2.35047251
78Impaired platelet aggregation (HP:0003540)2.35047251
79Pheochromocytoma (HP:0002666)2.33541501
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33280801
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33252001
82Dicarboxylic aciduria (HP:0003215)2.33252001
83Double outlet right ventricle (HP:0001719)2.30690115
84Congenital malformation of the right heart (HP:0011723)2.30690115
85Limb-girdle muscle atrophy (HP:0003797)2.29427506
86Increased intramyocellular lipid droplets (HP:0012240)2.28868331
87Acute lymphatic leukemia (HP:0006721)2.28190987
88Abnormality of fatty-acid metabolism (HP:0004359)2.27179656
89Lactic acidosis (HP:0003128)2.26995779
90Polygenic inheritance (HP:0010982)2.25643167
91Respiratory failure (HP:0002878)2.22932090
92Distal lower limb muscle weakness (HP:0009053)2.22331590
93Exercise intolerance (HP:0003546)2.20403080
94Aortic regurgitation (HP:0001659)2.20306060
95Mediastinal lymphadenopathy (HP:0100721)2.19432079
96Joint stiffness (HP:0001387)2.16200523
97Increased variability in muscle fiber diameter (HP:0003557)2.15794214
98Syringomyelia (HP:0003396)2.15652285
99Spinal cord lesions (HP:0100561)2.15652285
100Increased serum ferritin (HP:0003281)2.15172197
101Xanthomatosis (HP:0000991)2.14184388
102Thin bony cortex (HP:0002753)2.12821054
103Neuroendocrine neoplasm (HP:0100634)2.12704536
104Areflexia of lower limbs (HP:0002522)2.10042834
105Abnormality of the Achilles tendon (HP:0005109)2.09839101
106Myocardial infarction (HP:0001658)2.09122579
107Abnormality of the peritoneum (HP:0002585)2.08158269
108Congestive heart failure (HP:0001635)2.06909753
109Premature rupture of membranes (HP:0001788)2.06400170
110Dysmetric saccades (HP:0000641)2.05303751
111Obstructive sleep apnea (HP:0002870)2.05231738
112Abnormality of the foot musculature (HP:0001436)2.03971298
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02891679
114Abnormality of alanine metabolism (HP:0010916)2.02891679
115Hyperalaninemia (HP:0003348)2.02891679
116Reticulocytosis (HP:0001923)2.01726497
117Stroke (HP:0001297)2.00968802
118Neoplasm of the adrenal gland (HP:0100631)2.00595890
119Muscle stiffness (HP:0003552)2.00241656
120Abnormality of glycolipid metabolism (HP:0010969)2.00008329
121Abnormality of liposaccharide metabolism (HP:0010968)2.00008329
122Abnormality of glycosphingolipid metabolism (HP:0004343)2.00008329
123Hamartoma of the eye (HP:0010568)1.99807398
124Ketosis (HP:0001946)1.99482297
125Aortic aneurysm (HP:0004942)1.97072342
126Blue sclerae (HP:0000592)1.96969383
127Hypoplastic left heart (HP:0004383)1.96697553
128Spondylolisthesis (HP:0003302)1.96471819
129Elevated erythrocyte sedimentation rate (HP:0003565)1.96127164
130Esophageal neoplasm (HP:0100751)1.95293611
131Neoplasm of head and neck (HP:0012288)1.95293611
132Menorrhagia (HP:0000132)1.94589471
133Neck muscle weakness (HP:0000467)1.94156938
134Disproportionate tall stature (HP:0001519)1.93801401
135Large for gestational age (HP:0001520)1.93206761
136Achilles tendon contracture (HP:0001771)1.92463589
137Aneurysm (HP:0002617)1.91135990
138Fragile skin (HP:0001030)1.90629321
139Ectopia lentis (HP:0001083)1.90551492
140Emphysema (HP:0002097)1.90450898
141Lymphangioma (HP:0100764)1.87950980
142Pulmonary artery stenosis (HP:0004415)1.87894867
143EMG: neuropathic changes (HP:0003445)1.86589460
144Lipid accumulation in hepatocytes (HP:0006561)1.85301787
145Gingivitis (HP:0000230)1.85225664
146Nephritis (HP:0000123)1.84915961
147Dilatation of the ascending aorta (HP:0005111)1.84287154
148Bone pain (HP:0002653)1.83958396
149Distal lower limb amyotrophy (HP:0008944)1.82599683
150Foot dorsiflexor weakness (HP:0009027)1.82500289
151Genu recurvatum (HP:0002816)1.82341417
152Abnormality of skeletal muscle fiber size (HP:0012084)1.82100677
153Broad face (HP:0000283)1.81472443
154Abnormality of the thoracic spine (HP:0100711)1.81263486
155Mildly elevated creatine phosphokinase (HP:0008180)1.80369551
156Peritonitis (HP:0002586)1.80070278
157Epistaxis (HP:0000421)1.79866189
158Polycythemia (HP:0001901)1.78891655
159Athetosis (HP:0002305)1.78838126
160Urinary glycosaminoglycan excretion (HP:0003541)1.77722303
161Mucopolysacchariduria (HP:0008155)1.77722303
162Hypochromic anemia (HP:0001931)1.77057865
163Pathologic fracture (HP:0002756)1.76718667
164Hyperinsulinemic hypoglycemia (HP:0000825)1.76617839
165Tinnitus (HP:0000360)1.74896683
166Anteriorly placed anus (HP:0001545)1.74644711
167Central scotoma (HP:0000603)1.74609419
168Elbow flexion contracture (HP:0002987)1.74447904
169Abnormality of the anterior chamber (HP:0000593)1.74152446
170Recurrent gram-negative bacterial infections (HP:0005420)1.73582787
171Abnormality of pyrimidine metabolism (HP:0004353)1.73241907
172Meningitis (HP:0001287)1.72508819
173Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71565244
174Abnormality of polysaccharide metabolism (HP:0011012)1.71565244
175Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71565244
176Flared iliac wings (HP:0002869)1.70753596
177Annular pancreas (HP:0001734)1.70574638
178Muscular dystrophy (HP:0003560)1.69982324
179Hypobetalipoproteinemia (HP:0003563)1.69886099
180Abnormality of sulfur amino acid metabolism (HP:0004339)1.68959027
181Venous abnormality (HP:0002624)1.68745259
182Thin ribs (HP:0000883)1.68564181
183Agammaglobulinemia (HP:0004432)1.68271751
184Gowers sign (HP:0003391)1.68157178
185Myositis (HP:0100614)1.67809308
186Abnormality of the tricuspid valve (HP:0001702)1.66980483
187Bowing of the arm (HP:0006488)1.66425500
188Bowed forearm bones (HP:0003956)1.66425500
189Mitral valve prolapse (HP:0001634)1.65710001
190Gastrointestinal inflammation (HP:0004386)1.65693936
191Premature skin wrinkling (HP:0100678)1.65571443
192Stridor (HP:0010307)1.63521446
193Type 1 muscle fiber predominance (HP:0003803)1.63357970
194Abnormality of iron homeostasis (HP:0011031)1.62752555
195Multiple lipomas (HP:0001012)1.62407222
196Broad metatarsal (HP:0001783)1.60825263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.34423668
2LMTK24.38445035
3MYLK4.31700017
4PHKG23.98036024
5PHKG13.98036024
6PRPF4B3.86867137
7ERN13.64454787
8PKN23.53381237
9PDK43.28613515
10PDK33.28613515
11DMPK3.27955537
12TRIB32.87128772
13OBSCN2.80638528
14CDK122.51195628
15MAP3K132.45326695
16STK242.40207784
17MUSK2.38184608
18BCKDK2.30994970
19TIE12.25210475
20NEK12.22100660
21PIK3CA2.12737305
22MAP4K12.01050994
23MAP3K61.99143630
24EEF2K1.99142307
25PINK11.92315273
26SIK11.90917301
27KIT1.87689229
28PRKD21.85861666
29PDK21.84915213
30TAOK21.84620681
31SMG11.80046343
32PAK31.72373537
33BLK1.68732978
34GRK71.66023150
35CAMK2D1.51916585
36ILK1.46368930
37PRKD11.45284307
38TNK21.40834911
39IRAK31.34972194
40FES1.29710455
41TBK11.28827790
42IRAK21.25430315
43CDC42BPA1.25316587
44GRK61.23328553
45MAP3K141.23312779
46WNK41.17306526
47MAP2K61.17098353
48ZAP701.16398466
49MAP3K111.12880771
50CSF1R1.09587109
51SIK21.09089729
52DAPK31.07827624
53ROCK11.06881388
54MAP3K71.04808089
55CDK81.01673907
56MAPK120.99245349
57PTK2B0.98798149
58STK40.95672315
59MAPKAPK30.94450862
60CAMK40.93673713
61MARK20.92238311
62TAOK10.91743889
63RIPK10.91349213
64MAP3K50.90917146
65ABL20.88267703
66IRAK40.87872062
67FLT30.87182007
68CAMK2A0.86497144
69STK380.86451966
70CAMK10.84637889
71STK38L0.79683805
72PRKAA10.78794042
73CAMK1D0.77215572
74CHUK0.74490495
75PRKAA20.74256158
76ROCK20.73344328
77PKN10.73051746
78IKBKE0.72740714
79KDR0.72620469
80RIPK40.71730746
81BTK0.71554689
82RAF10.70461089
83MAPK40.69564228
84HIPK20.69403622
85PRKD30.69334045
86RPS6KC10.69024559
87RPS6KL10.69024559
88MAPK150.68638707
89FGFR40.68001967
90INSRR0.65628707
91CDK60.65584591
92ZAK0.64351072
93PDGFRA0.64131473
94TRPM70.63995729
95IRAK10.63683638
96PRKCE0.60802487
97CDK70.60615874
98NEK90.60395366
99MAP3K40.59554944
100RPS6KA60.57773887
101PIM20.57417928
102MOS0.56696668
103WNK10.55392661
104PAK20.54946254
105STK390.54186535
106PRKACB0.54101934
107CDK40.51717144
108PDPK10.50308983
109PIK3CG0.50251588
110CSK0.49183347
111ARAF0.49177921
112DDR20.47056724
113PRKACA0.46240799
114HCK0.45695116
115NTRK10.45680327
116PDK10.45545795
117TGFBR20.45405836
118SYK0.45263679
119IKBKB0.45242962
120PRKACG0.44677142
121EPHB10.43887111
122ICK0.43841867
123NME20.43397094
124CAMK2G0.41114180
125PDGFRB0.40814939
126JAK30.40731308
127RET0.38888705
128BMX0.38688638
129FER0.38369081
130LYN0.37378719
131MAP3K80.35252833
132JAK20.34917207
133PAK60.34849732
134DYRK1B0.34679712
135MAPK30.34623475
136MAP2K10.34454435
137PRKCH0.34053881
138MAP3K30.32925224
139MAPK100.32853697
140MAP2K30.29737172
141NTRK30.28991777
142NME10.28709526
143KSR20.28517073
144PTK60.25922209
145RPS6KA10.25830545
146RPS6KA20.25549318
147AKT20.24834078
148MAP3K10.22734764
149LATS20.21755905
150EPHA40.20565778
151SGK30.20076612
152MAP2K40.19944953
153PRKG20.18724113
154CAMK2B0.18322096
155UHMK10.17969266
156RPS6KA30.17070389
157SGK10.16909943
158PRKG10.15366683
159EPHB20.14019103
160PRKCQ0.12993848
161JAK10.12093553
162MTOR0.11952356
163MAP3K100.10265804
164CAMKK10.10229702
165GRK50.09877870
166MAPK110.09364912

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.75150087
2Cardiac muscle contraction_Homo sapiens_hsa042604.58078175
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.12341327
4Dilated cardiomyopathy_Homo sapiens_hsa054143.75557453
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.52689616
6Parkinsons disease_Homo sapiens_hsa050123.46416919
7Oxidative phosphorylation_Homo sapiens_hsa001903.38192329
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15287575
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.08168341
10Propanoate metabolism_Homo sapiens_hsa006402.91648524
11Fatty acid degradation_Homo sapiens_hsa000712.66009577
12Sulfur relay system_Homo sapiens_hsa041222.64210851
13Complement and coagulation cascades_Homo sapiens_hsa046102.63176909
14Alzheimers disease_Homo sapiens_hsa050102.60570484
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.30595501
16Carbon metabolism_Homo sapiens_hsa012002.28923930
17Systemic lupus erythematosus_Homo sapiens_hsa053222.27251286
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23533358
19Huntingtons disease_Homo sapiens_hsa050162.21402335
20Other glycan degradation_Homo sapiens_hsa005112.10756957
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.02824539
22Fatty acid metabolism_Homo sapiens_hsa012121.99529489
23Staphylococcus aureus infection_Homo sapiens_hsa051501.92890059
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91482601
25Pyruvate metabolism_Homo sapiens_hsa006201.69265402
26Viral myocarditis_Homo sapiens_hsa054161.61535515
27Caffeine metabolism_Homo sapiens_hsa002321.54813365
28Acute myeloid leukemia_Homo sapiens_hsa052211.54499323
29Prion diseases_Homo sapiens_hsa050201.53237930
30B cell receptor signaling pathway_Homo sapiens_hsa046621.42283359
31Leishmaniasis_Homo sapiens_hsa051401.36929156
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.33536876
33Osteoclast differentiation_Homo sapiens_hsa043801.31041759
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28605253
35Chronic myeloid leukemia_Homo sapiens_hsa052201.25863559
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18191307
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18060790
38Butanoate metabolism_Homo sapiens_hsa006501.17472571
39Fatty acid elongation_Homo sapiens_hsa000621.12151304
40Notch signaling pathway_Homo sapiens_hsa043301.09923106
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09717159
42Alcoholism_Homo sapiens_hsa050341.09382595
43Toxoplasmosis_Homo sapiens_hsa051451.05249354
44Calcium signaling pathway_Homo sapiens_hsa040201.02571450
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01238244
46Viral carcinogenesis_Homo sapiens_hsa052031.00987918
47Pertussis_Homo sapiens_hsa051330.99942588
48Biosynthesis of amino acids_Homo sapiens_hsa012300.98812690
49Pancreatic cancer_Homo sapiens_hsa052120.98137112
50Glucagon signaling pathway_Homo sapiens_hsa049220.97917527
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97318352
52ABC transporters_Homo sapiens_hsa020100.96242135
53Non-small cell lung cancer_Homo sapiens_hsa052230.95207339
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94662738
55Malaria_Homo sapiens_hsa051440.91538359
56Small cell lung cancer_Homo sapiens_hsa052220.90963128
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.89526325
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.89386222
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89332708
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89241649
61Insulin resistance_Homo sapiens_hsa049310.89024405
62PPAR signaling pathway_Homo sapiens_hsa033200.88604461
63Influenza A_Homo sapiens_hsa051640.86743312
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.84931495
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83311525
66TNF signaling pathway_Homo sapiens_hsa046680.82748776
67Insulin signaling pathway_Homo sapiens_hsa049100.81984473
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.81698586
69FoxO signaling pathway_Homo sapiens_hsa040680.80729380
70Glioma_Homo sapiens_hsa052140.79491206
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78594449
72Oxytocin signaling pathway_Homo sapiens_hsa049210.77588375
73Circadian entrainment_Homo sapiens_hsa047130.76772713
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76665657
75Type II diabetes mellitus_Homo sapiens_hsa049300.76493396
76Tuberculosis_Homo sapiens_hsa051520.75989901
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75801179
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73919373
79Renin secretion_Homo sapiens_hsa049240.73650108
80Hepatitis C_Homo sapiens_hsa051600.73056666
81African trypanosomiasis_Homo sapiens_hsa051430.71409646
82Starch and sucrose metabolism_Homo sapiens_hsa005000.70167314
83Bladder cancer_Homo sapiens_hsa052190.69872044
84Tyrosine metabolism_Homo sapiens_hsa003500.69020341
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68842527
86cAMP signaling pathway_Homo sapiens_hsa040240.68589724
87Hepatitis B_Homo sapiens_hsa051610.68091195
88Gastric acid secretion_Homo sapiens_hsa049710.68085443
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67891287
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.67770729
91Insulin secretion_Homo sapiens_hsa049110.67240259
92HIF-1 signaling pathway_Homo sapiens_hsa040660.67081483
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66936434
94Prolactin signaling pathway_Homo sapiens_hsa049170.66280956
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65011389
96Lysine degradation_Homo sapiens_hsa003100.63823960
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63193475
98Focal adhesion_Homo sapiens_hsa045100.61524775
99Arginine biosynthesis_Homo sapiens_hsa002200.61154187
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60041016
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.59732675
102beta-Alanine metabolism_Homo sapiens_hsa004100.58565707
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57038779
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55872442
105Fatty acid biosynthesis_Homo sapiens_hsa000610.55845031
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.55605718
107AMPK signaling pathway_Homo sapiens_hsa041520.54999307
108Hematopoietic cell lineage_Homo sapiens_hsa046400.54967968
109Tryptophan metabolism_Homo sapiens_hsa003800.54363785
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.54159636
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52457032
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51858709
113Folate biosynthesis_Homo sapiens_hsa007900.51841644
114MAPK signaling pathway_Homo sapiens_hsa040100.51783845
115Apoptosis_Homo sapiens_hsa042100.49920272
116Choline metabolism in cancer_Homo sapiens_hsa052310.49452700
117Olfactory transduction_Homo sapiens_hsa047400.48281539
118Arginine and proline metabolism_Homo sapiens_hsa003300.48065790
119Taste transduction_Homo sapiens_hsa047420.46081923
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.45510914
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45080133
122HTLV-I infection_Homo sapiens_hsa051660.44595370
123Prostate cancer_Homo sapiens_hsa052150.44524794
124Inositol phosphate metabolism_Homo sapiens_hsa005620.44299461
125MicroRNAs in cancer_Homo sapiens_hsa052060.44097899
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.43263169
127Lysosome_Homo sapiens_hsa041420.43031346
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.43019513
129Galactose metabolism_Homo sapiens_hsa000520.40562168
130Long-term potentiation_Homo sapiens_hsa047200.39941580
131Cholinergic synapse_Homo sapiens_hsa047250.38619056
132ECM-receptor interaction_Homo sapiens_hsa045120.38381932
133Salivary secretion_Homo sapiens_hsa049700.38213019
134Tight junction_Homo sapiens_hsa045300.37419899
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36114597
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36033233
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35192253
138Morphine addiction_Homo sapiens_hsa050320.34810570
139GnRH signaling pathway_Homo sapiens_hsa049120.33939966
140Peroxisome_Homo sapiens_hsa041460.32886264
141Gap junction_Homo sapiens_hsa045400.32467127
142Amoebiasis_Homo sapiens_hsa051460.30362520
143Dorso-ventral axis formation_Homo sapiens_hsa043200.29690450
144Phenylalanine metabolism_Homo sapiens_hsa003600.29012495
145VEGF signaling pathway_Homo sapiens_hsa043700.27745471
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27465237
147Glutamatergic synapse_Homo sapiens_hsa047240.27060018
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26013816
149Fructose and mannose metabolism_Homo sapiens_hsa000510.23286631
150GABAergic synapse_Homo sapiens_hsa047270.23005023
151Pancreatic secretion_Homo sapiens_hsa049720.22696283
152Estrogen signaling pathway_Homo sapiens_hsa049150.21213080
153Amphetamine addiction_Homo sapiens_hsa050310.20726190
154Metabolic pathways_Homo sapiens_hsa011000.20566617
155Dopaminergic synapse_Homo sapiens_hsa047280.20550288
156Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18112547
157Ovarian steroidogenesis_Homo sapiens_hsa049130.17441135
158Adherens junction_Homo sapiens_hsa045200.16611584
159Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16352178
160Bile secretion_Homo sapiens_hsa049760.15751579
161Renal cell carcinoma_Homo sapiens_hsa052110.14988005
162Cysteine and methionine metabolism_Homo sapiens_hsa002700.14936633
163Circadian rhythm_Homo sapiens_hsa047100.13394003
164Platelet activation_Homo sapiens_hsa046110.13301188
165mTOR signaling pathway_Homo sapiens_hsa041500.11014352
166Phospholipase D signaling pathway_Homo sapiens_hsa040720.10753374
167Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10201975

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