KCNG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.12898832
2sodium ion export (GO:0071436)7.84645294
3cellular potassium ion homeostasis (GO:0030007)7.35574075
4detection of light stimulus involved in sensory perception (GO:0050962)7.10434572
5detection of light stimulus involved in visual perception (GO:0050908)7.10434572
6G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.68748315
7negative regulation of cytosolic calcium ion concentration (GO:0051481)6.55111504
8synaptic vesicle exocytosis (GO:0016079)6.45031520
9gamma-aminobutyric acid signaling pathway (GO:0007214)6.26907221
10behavioral response to nicotine (GO:0035095)6.17991318
11potassium ion homeostasis (GO:0055075)5.97228307
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.92393216
13positive regulation of synapse maturation (GO:0090129)5.85145400
14synaptic vesicle endocytosis (GO:0048488)5.39452505
15protein localization to synapse (GO:0035418)5.35085647
16retinal rod cell development (GO:0046548)5.31297530
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.25939703
18relaxation of smooth muscle (GO:0044557)5.22048662
19cellular sodium ion homeostasis (GO:0006883)5.13055154
20cell communication by electrical coupling (GO:0010644)5.10941013
21synaptic vesicle maturation (GO:0016188)4.92605366
22cerebellar Purkinje cell differentiation (GO:0021702)4.87119983
23cerebellar granule cell differentiation (GO:0021707)4.78611583
24regulation of synaptic vesicle exocytosis (GO:2000300)4.73038046
25innervation (GO:0060384)4.71103765
26regulation of short-term neuronal synaptic plasticity (GO:0048172)4.69768641
27fucose catabolic process (GO:0019317)4.58747254
28L-fucose metabolic process (GO:0042354)4.58747254
29L-fucose catabolic process (GO:0042355)4.58747254
30regulation of synapse maturation (GO:0090128)4.52588114
31membrane depolarization during action potential (GO:0086010)4.45813427
32potassium ion import (GO:0010107)4.44533685
33mating behavior (GO:0007617)4.44311695
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.38415365
35prepulse inhibition (GO:0060134)4.30227021
36exploration behavior (GO:0035640)4.29700683
37neurotransmitter secretion (GO:0007269)4.28991759
38glutamate receptor signaling pathway (GO:0007215)4.27882002
39vocalization behavior (GO:0071625)4.17078307
40positive regulation of potassium ion transmembrane transport (GO:1901381)3.97901319
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97709830
42regulation of synaptic vesicle transport (GO:1902803)3.97652677
43striatum development (GO:0021756)3.92649892
44cell differentiation in hindbrain (GO:0021533)3.91087449
45neuroblast proliferation (GO:0007405)3.89425750
46establishment of synaptic vesicle localization (GO:0097480)3.85542357
47synaptic vesicle transport (GO:0048489)3.85542357
48calcium ion import (GO:0070509)3.85292109
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82923799
50regulation of voltage-gated calcium channel activity (GO:1901385)3.82641831
51C4-dicarboxylate transport (GO:0015740)3.81812809
52regulation of synapse structural plasticity (GO:0051823)3.81186975
53DNA deamination (GO:0045006)3.77244305
54neurotransmitter transport (GO:0006836)3.71388150
55indolalkylamine metabolic process (GO:0006586)3.66887863
56neuronal action potential propagation (GO:0019227)3.66137366
57tryptophan catabolic process (GO:0006569)3.64088416
58indole-containing compound catabolic process (GO:0042436)3.64088416
59indolalkylamine catabolic process (GO:0046218)3.64088416
60kynurenine metabolic process (GO:0070189)3.63891564
61retinal cone cell development (GO:0046549)3.59729710
62long-term synaptic potentiation (GO:0060291)3.59385104
63glutamate secretion (GO:0014047)3.57486110
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56956210
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55050722
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.52782849
67positive regulation of potassium ion transport (GO:0043268)3.51421869
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49990106
69water-soluble vitamin biosynthetic process (GO:0042364)3.48553287
70axon cargo transport (GO:0008088)3.47851587
71long term synaptic depression (GO:0060292)3.44549097
72regulation of neurotransmitter secretion (GO:0046928)3.40213526
73synapse assembly (GO:0007416)3.37567734
74cellular ketone body metabolic process (GO:0046950)3.37185967
75membrane hyperpolarization (GO:0060081)3.33360355
76cell communication involved in cardiac conduction (GO:0086065)3.32229547
77locomotory exploration behavior (GO:0035641)3.31904198
78neuron-neuron synaptic transmission (GO:0007270)3.28906280
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28241164
80regulation of neurotransmitter transport (GO:0051588)3.26948561
81sulfation (GO:0051923)3.26228145
82ionotropic glutamate receptor signaling pathway (GO:0035235)3.26067049
83sialylation (GO:0097503)3.22489803
84synaptic transmission, glutamatergic (GO:0035249)3.22160621
85glycolytic process (GO:0006096)3.21467189
86gamma-aminobutyric acid transport (GO:0015812)3.20520224
87piRNA metabolic process (GO:0034587)3.17537694
88mitochondrial respiratory chain complex I assembly (GO:0032981)3.17474755
89NADH dehydrogenase complex assembly (GO:0010257)3.17474755
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17474755
91protein polyglutamylation (GO:0018095)3.13956843
92platelet dense granule organization (GO:0060155)3.13107274
93tryptophan metabolic process (GO:0006568)3.12491635
94protein-cofactor linkage (GO:0018065)3.11082387
95regulation of neurotransmitter levels (GO:0001505)3.10876951
96nonmotile primary cilium assembly (GO:0035058)3.10574102
97protein complex biogenesis (GO:0070271)3.10533177
98neuronal action potential (GO:0019228)3.06407585
99regulation of vesicle fusion (GO:0031338)3.06213868
100ketone body metabolic process (GO:1902224)3.06196317
101axoneme assembly (GO:0035082)3.06122715
102sodium ion homeostasis (GO:0055078)3.06085211
103membrane repolarization (GO:0086009)3.05141878
104dendrite morphogenesis (GO:0048813)3.03931725
105epithelial cilium movement (GO:0003351)3.01728953
106regulation of synaptic transmission, glutamatergic (GO:0051966)3.00272468
107* cellular potassium ion transport (GO:0071804)2.98273333
108* potassium ion transmembrane transport (GO:0071805)2.98273333
109positive regulation of sodium ion transmembrane transport (GO:1902307)2.98084930
110nitric oxide mediated signal transduction (GO:0007263)2.97198583
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.95822813
112indole-containing compound metabolic process (GO:0042430)2.95528481
113phosphatidylinositol acyl-chain remodeling (GO:0036149)2.95429051
114regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94541759
115kidney morphogenesis (GO:0060993)2.93194112
116potassium ion export (GO:0071435)2.91783574
117adult walking behavior (GO:0007628)2.90368187
118regulation of membrane repolarization (GO:0060306)2.89990493
119synaptic transmission, cholinergic (GO:0007271)2.89548201
120regulation of ARF protein signal transduction (GO:0032012)2.89019532
121synapse organization (GO:0050808)2.88416500
122establishment of vesicle localization (GO:0051650)2.87926335
123neural tube formation (GO:0001841)2.87850861
124cell migration in hindbrain (GO:0021535)2.87674276
125mitochondrial respiratory chain complex assembly (GO:0033108)2.87555442
126negative regulation of telomere maintenance (GO:0032205)2.87173237
127glycine transport (GO:0015816)2.86185774
128neurotransmitter-gated ion channel clustering (GO:0072578)2.85340064
129apical protein localization (GO:0045176)2.84689223
130layer formation in cerebral cortex (GO:0021819)2.83917035
131acidic amino acid transport (GO:0015800)2.83340156
132lactate metabolic process (GO:0006089)2.82858822
133cornea development in camera-type eye (GO:0061303)2.82342464
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81825148
135negative regulation of mast cell activation (GO:0033004)2.80905253
136* synaptic transmission (GO:0007268)2.80363896
137long-term memory (GO:0007616)2.79667486
138nephron epithelium morphogenesis (GO:0072088)2.79492432
139nephron tubule morphogenesis (GO:0072078)2.79492432
140L-glutamate transport (GO:0015813)2.79406341
141primary amino compound metabolic process (GO:1901160)2.78773512
142ubiquinone biosynthetic process (GO:0006744)2.77746976
143regulation of cilium movement (GO:0003352)2.76696241
144behavioral response to ethanol (GO:0048149)2.76657577
145somite development (GO:0061053)2.70565310
146DNA methylation involved in gamete generation (GO:0043046)2.69349918
147amine catabolic process (GO:0009310)2.69251471
148cellular biogenic amine catabolic process (GO:0042402)2.69251471
149negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67229856
150replication fork processing (GO:0031297)2.66267237
151serotonin metabolic process (GO:0042428)2.66208546
152positive regulation of fatty acid transport (GO:2000193)2.64682452
153cilium morphogenesis (GO:0060271)2.64599479
154photoreceptor cell development (GO:0042461)2.63963984
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.62675428
156phosphatidylserine acyl-chain remodeling (GO:0036150)2.62425912
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62059447
158cAMP catabolic process (GO:0006198)2.61052112
159reflex (GO:0060004)2.60119198
160protein localization to cilium (GO:0061512)2.59378786
161multicellular organism reproduction (GO:0032504)2.58432758
162preassembly of GPI anchor in ER membrane (GO:0016254)2.57859835
163regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57553769
164ubiquinone metabolic process (GO:0006743)2.57212030
165protein K11-linked deubiquitination (GO:0035871)2.56897143
166negative regulation of reactive oxygen species metabolic process (GO:2000378)2.56363523
167mannosylation (GO:0097502)2.55274161
168pseudouridine synthesis (GO:0001522)2.55194843
169energy coupled proton transport, down electrochemical gradient (GO:0015985)2.54598867
170ATP synthesis coupled proton transport (GO:0015986)2.54598867
171cilium organization (GO:0044782)2.53626998
172photoreceptor cell maintenance (GO:0045494)2.53357251
173rhodopsin mediated signaling pathway (GO:0016056)2.52603552
174S-adenosylmethionine metabolic process (GO:0046500)2.51797422
175respiratory chain complex IV assembly (GO:0008535)2.50858366
176spinal cord motor neuron differentiation (GO:0021522)2.50440430
177cell proliferation in forebrain (GO:0021846)2.49973899
178phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.48344435
179negative regulation of T cell differentiation in thymus (GO:0033085)2.47711005
180startle response (GO:0001964)2.47285273
181cilium assembly (GO:0042384)2.44843727
182fucosylation (GO:0036065)2.43210194
183auditory receptor cell stereocilium organization (GO:0060088)2.42866955
184regulation of mesoderm development (GO:2000380)2.42767431
185mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41891584
186cilium movement (GO:0003341)2.41701525
187regulation of action potential (GO:0098900)2.40384196
188regulation of hippo signaling (GO:0035330)2.38515081
189regulation of glucokinase activity (GO:0033131)2.38502198
190regulation of hexokinase activity (GO:1903299)2.38502198
191transmission of nerve impulse (GO:0019226)2.38448592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.39005884
2DROSHA_22980978_ChIP-Seq_HELA_Human3.22224343
3GBX2_23144817_ChIP-Seq_PC3_Human3.09940990
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05849586
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94803632
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.92248538
7EZH2_22144423_ChIP-Seq_EOC_Human2.78309318
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69790601
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.64999320
10* EZH2_27294783_Chip-Seq_ESCs_Mouse2.64878454
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62096968
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56435116
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51703620
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51022096
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51022096
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49604531
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43440073
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.41451491
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.35790673
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33279186
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30669728
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29383661
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.25875459
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.12936038
25AR_21572438_ChIP-Seq_LNCaP_Human2.11681096
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08127363
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07442645
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.06331064
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01881277
30EWS_26573619_Chip-Seq_HEK293_Human2.01042376
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98490179
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.90909935
33P53_22127205_ChIP-Seq_FIBROBLAST_Human1.82666651
34ER_23166858_ChIP-Seq_MCF-7_Human1.82330285
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78112926
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78070100
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77013750
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76893640
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.75313837
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.74968480
41IRF1_19129219_ChIP-ChIP_H3396_Human1.72174394
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69797928
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66582854
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65493763
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65073135
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64025593
47SMAD4_21799915_ChIP-Seq_A2780_Human1.62864628
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61980162
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61884824
50TP53_22573176_ChIP-Seq_HFKS_Human1.58432924
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57827112
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57379783
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54689881
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54042265
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53588649
56IGF1R_20145208_ChIP-Seq_DFB_Human1.53503623
57BCAT_22108803_ChIP-Seq_LS180_Human1.53263546
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.51528224
59AR_19668381_ChIP-Seq_PC3_Human1.46594980
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42731337
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42731337
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41503233
63MYC_18940864_ChIP-ChIP_HL60_Human1.41088340
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.40791599
65AR_25329375_ChIP-Seq_VCAP_Human1.38881326
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33660716
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33532131
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32687049
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32663025
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.32177958
71RNF2_27304074_Chip-Seq_NSC_Mouse1.31910881
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.31619980
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31566019
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30958816
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.30958816
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.29802986
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29662368
78SOX2_19829295_ChIP-Seq_ESCs_Human1.26704714
79NANOG_19829295_ChIP-Seq_ESCs_Human1.26704714
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26268264
81* GATA3_21878914_ChIP-Seq_MCF-7_Human1.25843579
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.24878405
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.23822927
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23533083
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23383427
86TCF4_22108803_ChIP-Seq_LS180_Human1.23055490
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21440872
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20563930
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20474466
90ZNF274_21170338_ChIP-Seq_K562_Hela1.19942526
91NCOR_22424771_ChIP-Seq_293T_Human1.18565830
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17903571
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.16481227
94CBP_20019798_ChIP-Seq_JUKART_Human1.16460831
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16460831
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.15232852
97STAT3_23295773_ChIP-Seq_U87_Human1.14231543
98AR_20517297_ChIP-Seq_VCAP_Human1.13941655
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13658291
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.13391176
101HOXB7_26014856_ChIP-Seq_BT474_Human1.13188853
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12696892
103RUNX2_22187159_ChIP-Seq_PCA_Human1.12539171
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12266469
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11931853
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.11862804
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10677404
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10149798
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09905557
110* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09483469
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09456750
112TCF4_23295773_ChIP-Seq_U87_Human1.09043515
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08316838
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.07139393
115CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05470189
116SMAD3_21741376_ChIP-Seq_ESCs_Human1.05415788
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04280154
118* SMAD4_21741376_ChIP-Seq_HESCs_Human1.04057643
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.03939163
120KDM2B_26808549_Chip-Seq_K562_Human1.01286840
121MYC_19829295_ChIP-Seq_ESCs_Human1.01022292
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99753959
123P53_22387025_ChIP-Seq_ESCs_Mouse0.99380235
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99074933
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98694190
126FLI1_21867929_ChIP-Seq_TH2_Mouse0.98606065
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.98304054
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.98044832
129ERA_21632823_ChIP-Seq_H3396_Human0.97300708
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96003425
131P300_19829295_ChIP-Seq_ESCs_Human0.95926183
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95202240
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.94266388
134POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93949601
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92510793
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92480181
137* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91211646
138* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90977727
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89966286
140TAF15_26573619_Chip-Seq_HEK293_Human0.89944317
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89259534
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.89033161
143FUS_26573619_Chip-Seq_HEK293_Human0.88403981
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87866294
145CTCF_27219007_Chip-Seq_Bcells_Human0.87766417
146* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86329535
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.85843508
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85608576
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85082257
150WDR5_24793694_ChIP-Seq_LNCAP_Human0.85039019
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84855207
152* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83663819
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83330789
154GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82899690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.63452910
2MP0009046_muscle_twitch3.76904809
3MP0006072_abnormal_retinal_apoptosis3.44818701
4MP0002090_abnormal_vision3.43107264
5MP0001984_abnormal_olfaction3.32306169
6MP0004859_abnormal_synaptic_plasticity3.32175568
7MP0003635_abnormal_synaptic_transmissio3.04879737
8MP0004145_abnormal_muscle_electrophysio3.03984048
9MP0004233_abnormal_muscle_weight2.88971694
10MP0001502_abnormal_circadian_rhythm2.84621071
11MP0008877_abnormal_DNA_methylation2.82297045
12MP0001486_abnormal_startle_reflex2.67312105
13MP0003195_calcinosis2.66291953
14MP0008569_lethality_at_weaning2.65123832
15MP0002064_seizures2.64281068
16MP0002272_abnormal_nervous_system2.49398958
17MP0004215_abnormal_myocardial_fiber2.40275962
18MP0002102_abnormal_ear_morphology2.38587772
19MP0003787_abnormal_imprinting2.36729393
20MP0009745_abnormal_behavioral_response2.36568683
21MP0003880_abnormal_central_pattern2.35776313
22MP0004782_abnormal_surfactant_physiolog2.34956780
23MP0002067_abnormal_sensory_capabilities2.32572501
24MP0002734_abnormal_mechanical_nocicepti2.27956752
25MP0002063_abnormal_learning/memory/cond2.21677589
26MP0000569_abnormal_digit_pigmentation2.16246490
27MP0005253_abnormal_eye_physiology2.15190441
28MP0002184_abnormal_innervation2.07142566
29MP0002837_dystrophic_cardiac_calcinosis2.05969697
30MP0005423_abnormal_somatic_nervous1.95976012
31MP0001986_abnormal_taste_sensitivity1.95505502
32MP0004270_analgesia1.94454170
33MP0003136_yellow_coat_color1.94375874
34MP0001968_abnormal_touch/_nociception1.91728679
35MP0001485_abnormal_pinna_reflex1.86484959
36MP0002572_abnormal_emotion/affect_behav1.83013801
37MP0005646_abnormal_pituitary_gland1.82758500
38MP0005195_abnormal_posterior_eye1.78134129
39MP0008875_abnormal_xenobiotic_pharmacok1.78119760
40MP0004133_heterotaxia1.77773903
41MP0004142_abnormal_muscle_tone1.76478454
42MP0005394_taste/olfaction_phenotype1.67365588
43MP0005499_abnormal_olfactory_system1.67365588
44MP0003137_abnormal_impulse_conducting1.64252330
45MP0002876_abnormal_thyroid_physiology1.64022056
46MP0000427_abnormal_hair_cycle1.63792992
47MP0004036_abnormal_muscle_relaxation1.63076577
48MP0002736_abnormal_nociception_after1.62929842
49MP0006292_abnormal_olfactory_placode1.62057162
50MP0001501_abnormal_sleep_pattern1.61688197
51MP0002332_abnormal_exercise_endurance1.61045622
52MP0003329_amyloid_beta_deposits1.59764626
53MP0002229_neurodegeneration1.59082981
54MP0000372_irregular_coat_pigmentation1.56028426
55MP0005645_abnormal_hypothalamus_physiol1.54254266
56MP0002938_white_spotting1.53741262
57MP0008775_abnormal_heart_ventricle1.53526088
58MP0004084_abnormal_cardiac_muscle1.50766179
59MP0002653_abnormal_ependyma_morphology1.49535748
60MP0000751_myopathy1.48163616
61MP0002638_abnormal_pupillary_reflex1.44656403
62MP0002882_abnormal_neuron_morphology1.44275323
63MP0001346_abnormal_lacrimal_gland1.43550652
64MP0000955_abnormal_spinal_cord1.41122875
65MP0002557_abnormal_social/conspecific_i1.38164812
66MP0002752_abnormal_somatic_nervous1.37037229
67MP0003890_abnormal_embryonic-extraembry1.34897354
68MP0005248_abnormal_Harderian_gland1.34783164
69MP0001440_abnormal_grooming_behavior1.33928724
70MP0002160_abnormal_reproductive_system1.33361451
71MP0004043_abnormal_pH_regulation1.33332954
72MP0005389_reproductive_system_phenotype1.33201898
73MP0005670_abnormal_white_adipose1.30645003
74MP0003950_abnormal_plasma_membrane1.28301191
75MP0005377_hearing/vestibular/ear_phenot1.28026376
76MP0003878_abnormal_ear_physiology1.28026376
77MP0002066_abnormal_motor_capabilities/c1.26462263
78MP0001970_abnormal_pain_threshold1.24421235
79MP0008789_abnormal_olfactory_epithelium1.23836169
80MP0004742_abnormal_vestibular_system1.22750455
81MP0004885_abnormal_endolymph1.22723108
82MP0000631_abnormal_neuroendocrine_gland1.20804806
83MP0003633_abnormal_nervous_system1.19970633
84MP0005174_abnormal_tail_pigmentation1.19730762
85MP0005084_abnormal_gallbladder_morpholo1.17216145
86MP0000013_abnormal_adipose_tissue1.16295731
87MP0005595_abnormal_vascular_smooth1.16050181
88MP0001919_abnormal_reproductive_system1.15373877
89MP0004924_abnormal_behavior1.14512854
90MP0005386_behavior/neurological_phenoty1.14512854
91MP0002163_abnormal_gland_morphology1.14510989
92MP0004811_abnormal_neuron_physiology1.11315298
93MP0010386_abnormal_urinary_bladder1.10042277
94MP0003121_genomic_imprinting1.09776167
95MP0003283_abnormal_digestive_organ1.08598887
96MP0003646_muscle_fatigue1.07965959
97MP0003879_abnormal_hair_cell1.06171330
98MP0003634_abnormal_glial_cell1.05794750
99MP0000383_abnormal_hair_follicle1.04903799
100MP0002152_abnormal_brain_morphology1.04855299
101MP0002909_abnormal_adrenal_gland1.00816614
102MP0005379_endocrine/exocrine_gland_phen1.00581225
103MP0002928_abnormal_bile_duct1.00405558
104MP0003631_nervous_system_phenotype0.99756001
105MP0002234_abnormal_pharynx_morphology0.98741952
106MP0000026_abnormal_inner_ear0.98244039
107MP0001529_abnormal_vocalization0.97557755
108MP0001324_abnormal_eye_pigmentation0.96723809
109MP0008872_abnormal_physiological_respon0.94439499
110MP0010030_abnormal_orbit_morphology0.94042422
111MP0002735_abnormal_chemical_nociception0.92968764
112MP0002069_abnormal_eating/drinking_beha0.92900179
113MP0005075_abnormal_melanosome_morpholog0.92197861
114MP0001188_hyperpigmentation0.92164365
115MP0005410_abnormal_fertilization0.91517146
116MP0005167_abnormal_blood-brain_barrier0.91333742
117MP0002277_abnormal_respiratory_mucosa0.91213312
118MP0002095_abnormal_skin_pigmentation0.90607726
119MP0001905_abnormal_dopamine_level0.89990686
120MP0000747_muscle_weakness0.89786414
121MP0000778_abnormal_nervous_system0.88143357
122MP0002733_abnormal_thermal_nociception0.87514575
123MP0003698_abnormal_male_reproductive0.86094621
124MP0002254_reproductive_system_inflammat0.85430853
125MP0003718_maternal_effect0.84580610
126MP0005620_abnormal_muscle_contractility0.83613003
127MP0003122_maternal_imprinting0.83409049
128MP0003119_abnormal_digestive_system0.82508548
129MP0003632_abnormal_nervous_system0.81946966
130MP0004147_increased_porphyrin_level0.80617986
131MP0000230_abnormal_systemic_arterial0.80392713
132MP0000749_muscle_degeneration0.79636178
133MP0008995_early_reproductive_senescence0.78399124
134MP0002089_abnormal_postnatal_growth/wei0.77475894
135MP0002693_abnormal_pancreas_physiology0.76990021
136MP0002269_muscular_atrophy0.76141712
137MP0004085_abnormal_heartbeat0.74081469
138MP0003011_delayed_dark_adaptation0.70970737
139MP0005391_vision/eye_phenotype0.69657077
140MP0001963_abnormal_hearing_physiology0.68081022
141MP0004858_abnormal_nervous_system0.66706711
142MP0000920_abnormal_myelination0.64816748
143MP0006276_abnormal_autonomic_nervous0.64337601
144MP0010769_abnormal_survival0.62401202
145MP0006035_abnormal_mitochondrial_morpho0.61685320

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)7.00369356
2Abnormality of macular pigmentation (HP:0008002)6.02221799
3Severe visual impairment (HP:0001141)5.42352534
4Progressive cerebellar ataxia (HP:0002073)5.36925805
5Septo-optic dysplasia (HP:0100842)5.22257992
6Febrile seizures (HP:0002373)5.21549364
7Epileptic encephalopathy (HP:0200134)4.92213944
8Action tremor (HP:0002345)4.71697109
9Scotoma (HP:0000575)4.54498205
10Visual hallucinations (HP:0002367)4.51262145
11Molar tooth sign on MRI (HP:0002419)4.29253726
12Abnormality of midbrain morphology (HP:0002418)4.29253726
13Pancreatic cysts (HP:0001737)4.27010915
14Abnormal rod and cone electroretinograms (HP:0008323)4.21094483
15Hemiparesis (HP:0001269)4.20008432
16Myokymia (HP:0002411)4.09110677
17Pancreatic fibrosis (HP:0100732)4.07800931
18Dysdiadochokinesis (HP:0002075)3.98131590
19Absence seizures (HP:0002121)3.90278555
20True hermaphroditism (HP:0010459)3.81085297
21Type II lissencephaly (HP:0007260)3.66885117
22Nephronophthisis (HP:0000090)3.62838835
23Aplasia/Hypoplasia of the fovea (HP:0008060)3.57319366
24Hypoplasia of the fovea (HP:0007750)3.57319366
25Albinism (HP:0001022)3.51473820
26Hemiplegia (HP:0002301)3.48048733
27Decreased central vision (HP:0007663)3.41344968
28Exercise-induced myalgia (HP:0003738)3.41196995
29Abnormal gallbladder physiology (HP:0012438)3.37933062
30Cholecystitis (HP:0001082)3.37933062
31Abnormality of the renal cortex (HP:0011035)3.35987614
32Focal motor seizures (HP:0011153)3.33937669
33Dialeptic seizures (HP:0011146)3.27178744
34Mutism (HP:0002300)3.23894342
35Abnormality of the renal medulla (HP:0100957)3.20291213
36Ventricular fibrillation (HP:0001663)3.07449753
37Hyperventilation (HP:0002883)3.04836278
38Atonic seizures (HP:0010819)3.04222126
39Chronic hepatic failure (HP:0100626)3.02202520
40Abnormality of the fovea (HP:0000493)3.01871009
41Gaze-evoked nystagmus (HP:0000640)2.98459439
42Exercise-induced muscle cramps (HP:0003710)2.98295369
43Scanning speech (HP:0002168)2.94779003
44Depression (HP:0000716)2.91718798
45Optic nerve hypoplasia (HP:0000609)2.91322435
46Focal seizures (HP:0007359)2.88345234
47Medial flaring of the eyebrow (HP:0010747)2.86507807
48Absent septum pellucidum (HP:0001331)2.86280945
49Dysmetria (HP:0001310)2.83522850
50Dysmetric saccades (HP:0000641)2.82383957
51Tubular atrophy (HP:0000092)2.82198905
52Pendular nystagmus (HP:0012043)2.78320552
53Abolished electroretinogram (ERG) (HP:0000550)2.76701587
54Supranuclear gaze palsy (HP:0000605)2.74565966
55Abnormality of the lower motor neuron (HP:0002366)2.72150752
56Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.71060251
57Cystic liver disease (HP:0006706)2.60983290
58Prolonged QT interval (HP:0001657)2.59612200
59Abnormal drinking behavior (HP:0030082)2.58456477
60Polydipsia (HP:0001959)2.58456477
61Cerebellar dysplasia (HP:0007033)2.56239506
62Generalized tonic-clonic seizures (HP:0002069)2.53812612
63Genetic anticipation (HP:0003743)2.53525194
64Bony spicule pigmentary retinopathy (HP:0007737)2.52152146
65Ankle clonus (HP:0011448)2.51788629
66Renal cortical cysts (HP:0000803)2.50523826
67Abnormality of alanine metabolism (HP:0010916)2.49537306
68Hyperalaninemia (HP:0003348)2.49537306
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49537306
70Abnormality of the sella turcica (HP:0002679)2.46433784
71Lissencephaly (HP:0001339)2.46288513
72Congenital, generalized hypertrichosis (HP:0004540)2.41555175
73Acute necrotizing encephalopathy (HP:0006965)2.40918442
74Abnormality of ocular smooth pursuit (HP:0000617)2.39899199
75Neoplasm of the heart (HP:0100544)2.38859620
76Truncal ataxia (HP:0002078)2.38705088
77Aplasia/Hypoplasia of the macula (HP:0008059)2.38534675
78Hand muscle atrophy (HP:0009130)2.37039163
79Sclerocornea (HP:0000647)2.35676744
80Aplasia/Hypoplasia affecting the retina (HP:0008061)2.33928786
81Inability to walk (HP:0002540)2.33505760
82Impaired smooth pursuit (HP:0007772)2.33283642
83Abnormality of the septum pellucidum (HP:0007375)2.32396471
84Unsteady gait (HP:0002317)2.31107491
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30096117
86Abnormal pupillary function (HP:0007686)2.28865653
87Chorioretinal atrophy (HP:0000533)2.27432494
88Tetraplegia (HP:0002445)2.26275821
89Anencephaly (HP:0002323)2.24496679
90Acute encephalopathy (HP:0006846)2.21295568
91Congenital primary aphakia (HP:0007707)2.21236747
92Myoglobinuria (HP:0002913)2.19992076
93Increased corneal curvature (HP:0100692)2.19894257
94Keratoconus (HP:0000563)2.19894257
95Intention tremor (HP:0002080)2.19011597
96Furrowed tongue (HP:0000221)2.18085168
97Large for gestational age (HP:0001520)2.17362460
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.16913255
99Mitochondrial inheritance (HP:0001427)2.15531769
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12589815
101Progressive macrocephaly (HP:0004481)2.11558530
102Polyuria (HP:0000103)2.10929763
103Generalized hypopigmentation (HP:0007513)2.10247904
104Muscle stiffness (HP:0003552)2.09877521
105Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09662839
106Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08559742
107Increased CSF lactate (HP:0002490)2.08252709
108Congenital hepatic fibrosis (HP:0002612)2.08217873
109Dynein arm defect of respiratory motile cilia (HP:0012255)2.08050295
110Absent/shortened dynein arms (HP:0200106)2.08050295
111Optic disc pallor (HP:0000543)2.07300422
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.05238230
113Progressive inability to walk (HP:0002505)2.04910593
114Nephrogenic diabetes insipidus (HP:0009806)2.04471168
115Male pseudohermaphroditism (HP:0000037)2.04026792
116Abnormal mitochondria in muscle tissue (HP:0008316)2.03851759
117Anxiety (HP:0000739)2.03532063
118Decreased circulating renin level (HP:0003351)2.02864013
119Postural instability (HP:0002172)2.02417745
120Status epilepticus (HP:0002133)2.02126930
121Congenital stationary night blindness (HP:0007642)11.2785114
122Limb ataxia (HP:0002070)1.99409088
123Bile duct proliferation (HP:0001408)1.98651230
124Abnormal biliary tract physiology (HP:0012439)1.98651230
125Abnormality of the pons (HP:0007361)1.97203851
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.95852428
127Abnormal respiratory epithelium morphology (HP:0012253)1.95799500
128Abnormal respiratory motile cilium morphology (HP:0005938)1.95799500
129Severe muscular hypotonia (HP:0006829)1.95100110
130Severe Myopia (HP:0011003)1.94152074
131Excessive salivation (HP:0003781)1.93584301
132Drooling (HP:0002307)1.93584301
133Protruding tongue (HP:0010808)1.93557492
134Hypoplasia of the pons (HP:0012110)1.93207942
135Pachygyria (HP:0001302)1.92380498
136Fatigue (HP:0012378)1.92105474
137Genital tract atresia (HP:0001827)1.91448812
138Concave nail (HP:0001598)1.89944117
139Attenuation of retinal blood vessels (HP:0007843)1.86398040
140Oligodactyly (hands) (HP:0001180)1.85842624
141Abnormal EKG (HP:0003115)1.84857111
142Increased cerebral lipofuscin (HP:0011813)1.84411775
143Abnormality of binocular vision (HP:0011514)1.84386646
144Diplopia (HP:0000651)1.84386646
145Urinary bladder sphincter dysfunction (HP:0002839)1.84321694
146Growth hormone deficiency (HP:0000824)1.84202606
147Patellar aplasia (HP:0006443)1.83948733
148Methylmalonic acidemia (HP:0002912)1.83945473
149Increased neuronal autofluorescent lipopigment (HP:0002074)1.83507255
150Flat cornea (HP:0007720)1.82874971
151Vaginal atresia (HP:0000148)1.82249131
152Distal upper limb amyotrophy (HP:0007149)1.82191366
153Upper limb amyotrophy (HP:0009129)1.82191366
154Abnormal eating behavior (HP:0100738)1.81915554
155Hyperglycinuria (HP:0003108)1.81395870
156Birth length less than 3rd percentile (HP:0003561)1.81330313
157Congenital sensorineural hearing impairment (HP:0008527)1.81314451
158Aplasia/Hypoplasia of the patella (HP:0006498)1.80679898
159Postaxial foot polydactyly (HP:0001830)1.80151564
160Clonus (HP:0002169)1.79874417
161Occipital encephalocele (HP:0002085)1.79273527
162Asplenia (HP:0001746)1.78896882
163Spastic gait (HP:0002064)1.78466939
164Clumsiness (HP:0002312)1.76353920
165Broad-based gait (HP:0002136)1.76258036
1663-Methylglutaconic aciduria (HP:0003535)1.75894270
167Abnormal ciliary motility (HP:0012262)1.74699313
168Gait imbalance (HP:0002141)1.73534972
169Methylmalonic aciduria (HP:0012120)1.72476501
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.72197191
171Fetal akinesia sequence (HP:0001989)1.71996895
172Abnormality of saccadic eye movements (HP:0000570)1.71281032
173Bilateral microphthalmos (HP:0007633)1.70801328
174Stomach cancer (HP:0012126)1.70182628
175Agitation (HP:0000713)1.69861142
176EEG with generalized epileptiform discharges (HP:0011198)1.69140964
177Incomplete penetrance (HP:0003829)1.67771506
178Epileptiform EEG discharges (HP:0011182)1.63738279
179Retinal dysplasia (HP:0007973)1.62834235
180Primary adrenal insufficiency (HP:0008207)1.62531948
181Cholelithiasis (HP:0001081)1.62134132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.93308988
2ADRBK23.81927012
3PAK63.65864467
4MAP3K43.53574129
5PRPF4B3.12210128
6NEK13.05535555
7PHKG13.04514322
8PHKG23.04514322
9BMPR1B3.01625364
10MAP4K22.88820668
11STK382.81507383
12NUAK12.71762322
13RIPK12.64359772
14WNK42.59943938
15ACVR1B2.59641329
16MAP3K92.52729665
17MINK12.45271732
18GRK12.43723114
19ZAK2.42633130
20TAOK22.34495141
21CAMKK22.20898970
22TAOK32.17614535
23TLK12.14854532
24DYRK1A2.12882762
25NTRK32.05105379
26WNK11.89327016
27TXK1.87538351
28PINK11.78671102
29MARK11.77525531
30MAP2K71.69189513
31TNK21.67421033
32CAMKK11.61624246
33MAP2K41.58358036
34STK391.56083915
35INSRR1.51733512
36PRKCG1.43090135
37TNIK1.40035007
38ADRBK11.35126276
39NTRK21.31558489
40MAP3K71.26207454
41SGK2231.24863617
42SGK4941.24863617
43DYRK21.24499304
44CDK151.24243829
45NME11.22126828
46CDK181.18381574
47CDK141.13971044
48KSR21.13839139
49MKNK21.12187043
50CDK11A1.10481045
51TGFBR11.10410761
52PNCK1.09408818
53CDK51.05102830
54ROCK21.04008581
55CAMK2D1.02396931
56VRK11.00087038
57FER0.99780167
58MAPK150.96765329
59MAPK130.95740839
60ICK0.95608818
61PRKAA10.95397433
62TAF10.94054243
63CDK30.92961343
64CAMK10.92130146
65TRIM280.91441630
66TIE10.91345452
67MAP3K130.90103191
68FES0.89519345
69EPHA30.89080894
70BMX0.88335654
71SGK20.87463057
72CDC42BPA0.85644036
73MST40.82577792
74CDK190.81901165
75PRKG10.80243371
76MAP2K60.79757650
77PLK20.78560284
78GRK50.77779643
79PIK3CA0.77397360
80PTK2B0.76749000
81LMTK20.76606891
82CAMK2G0.76522613
83CDK80.75649344
84MAPK100.75491450
85MAPKAPK30.74572703
86IKBKB0.74551931
87CAMK2A0.73704392
88SGK30.72080039
89BCKDK0.71564200
90DAPK20.70457346
91PRKCQ0.69894951
92KSR10.69465904
93NEK60.68803733
94RPS6KA30.66803988
95CAMK1G0.66500564
96OBSCN0.64574859
97MUSK0.63814889
98BRSK20.62296779
99MAPKAPK50.61775919
100TEC0.61500459
101PRKACB0.61266389
102STK110.61242196
103PRKD30.61169188
104SIK20.60557221
105STK38L0.60479086
106MARK20.60424105
107PAK30.59430964
108EPHA40.59174337
109WEE10.59135610
110PRKACA0.57253278
111NLK0.56095083
112NTRK10.55966475
113IRAK10.55383569
114PRKCA0.55334747
115STK160.54587595
116LATS20.54275219
117CASK0.53229521
118SGK10.52767920
119OXSR10.52541006
120PRKCE0.52464191
121GRK70.52336421
122PRKCH0.51472894
123PLK30.51126147
124CSNK1G20.50987234
125NEK20.50426615
126FGFR20.50193813
127GSK3B0.49666264
128VRK20.49346176
129PDK20.49014418
130MAP2K20.48136520
131ITK0.47528976
132PKN10.47414170
133PRKCZ0.46348887
134RPS6KA50.45494389
135PRKCI0.45195859
136CAMK40.44632904
137ARAF0.44392584
138RET0.43630107
139MKNK10.43189613
140BRD40.43128616
141PRKCB0.43008609
142CSNK1G10.42902368
143CSNK1A10.42524984
144MAPK80.42356816
145STK30.42190394
146FYN0.41481715
147PLK40.41469933
148CAMK2B0.40882668
149WNK30.40495797
150ERBB30.39753798
151CAMK1D0.39254414
152MAPK120.39180842
153PRKG20.38462430
154PTK20.37662459
155MAPK90.36802316
156UHMK10.36228112
157PRKACG0.35284218
158CSNK1G30.33503973
159CHUK0.33375464
160ERBB20.33072843
161CHEK20.32213207
162CSNK1A1L0.29923816
163TSSK60.29857576
164KIT0.29499928

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.07003251
2GABAergic synapse_Homo sapiens_hsa047273.73638218
3Synaptic vesicle cycle_Homo sapiens_hsa047213.52793139
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.41989419
5Morphine addiction_Homo sapiens_hsa050323.13481933
6Linoleic acid metabolism_Homo sapiens_hsa005912.88684676
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86138903
8Circadian entrainment_Homo sapiens_hsa047132.71891860
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.70693663
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57174306
11Oxidative phosphorylation_Homo sapiens_hsa001902.45213909
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36151605
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35679752
14Glutamatergic synapse_Homo sapiens_hsa047242.26678632
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17066418
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13451394
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12938122
18Salivary secretion_Homo sapiens_hsa049702.10160268
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.06183893
20Circadian rhythm_Homo sapiens_hsa047102.00844022
21Insulin secretion_Homo sapiens_hsa049112.00792339
22Butanoate metabolism_Homo sapiens_hsa006501.99207524
23Ether lipid metabolism_Homo sapiens_hsa005651.87692886
24Cardiac muscle contraction_Homo sapiens_hsa042601.86337959
25Parkinsons disease_Homo sapiens_hsa050121.85819872
26Tryptophan metabolism_Homo sapiens_hsa003801.80889865
27Basal transcription factors_Homo sapiens_hsa030221.77421504
28Cholinergic synapse_Homo sapiens_hsa047251.77034389
29Renin secretion_Homo sapiens_hsa049241.76252589
30Oxytocin signaling pathway_Homo sapiens_hsa049211.75293540
31Olfactory transduction_Homo sapiens_hsa047401.73523046
32RNA polymerase_Homo sapiens_hsa030201.71842826
33Selenocompound metabolism_Homo sapiens_hsa004501.71818645
34Fructose and mannose metabolism_Homo sapiens_hsa000511.71282469
35Long-term depression_Homo sapiens_hsa047301.68293021
36Protein export_Homo sapiens_hsa030601.67720034
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66512840
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63076505
39Homologous recombination_Homo sapiens_hsa034401.61730110
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57968990
41Taste transduction_Homo sapiens_hsa047421.55111227
42Dopaminergic synapse_Homo sapiens_hsa047281.54731626
43Caffeine metabolism_Homo sapiens_hsa002321.54316411
44Fanconi anemia pathway_Homo sapiens_hsa034601.48500203
45Serotonergic synapse_Homo sapiens_hsa047261.47932588
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44662036
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39575630
48Calcium signaling pathway_Homo sapiens_hsa040201.37188730
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35336396
50Long-term potentiation_Homo sapiens_hsa047201.34819378
51Propanoate metabolism_Homo sapiens_hsa006401.31708890
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31609654
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31352679
54Huntingtons disease_Homo sapiens_hsa050161.29688433
55Gastric acid secretion_Homo sapiens_hsa049711.26906002
56Alzheimers disease_Homo sapiens_hsa050101.23744345
57Type II diabetes mellitus_Homo sapiens_hsa049301.22838119
58Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21120381
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20938690
60Sulfur relay system_Homo sapiens_hsa041221.19622359
61One carbon pool by folate_Homo sapiens_hsa006701.18977557
62Dilated cardiomyopathy_Homo sapiens_hsa054141.18316738
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.15410424
64Amphetamine addiction_Homo sapiens_hsa050311.14747386
65cAMP signaling pathway_Homo sapiens_hsa040241.12644324
66RNA degradation_Homo sapiens_hsa030181.11787401
67Intestinal immune network for IgA production_Homo sapiens_hsa046721.10614010
68Chemical carcinogenesis_Homo sapiens_hsa052041.09971056
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09207363
70Regulation of autophagy_Homo sapiens_hsa041401.09119516
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07547585
72Pentose phosphate pathway_Homo sapiens_hsa000301.07292126
73Primary bile acid biosynthesis_Homo sapiens_hsa001201.05645590
74Biosynthesis of amino acids_Homo sapiens_hsa012301.05419011
75Mineral absorption_Homo sapiens_hsa049781.04613740
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03926053
77Arachidonic acid metabolism_Homo sapiens_hsa005901.02842327
78Gap junction_Homo sapiens_hsa045401.01953857
79Central carbon metabolism in cancer_Homo sapiens_hsa052301.01518563
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99561821
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96273549
82Peroxisome_Homo sapiens_hsa041460.95807016
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95657376
84Retinol metabolism_Homo sapiens_hsa008300.94691441
85Ribosome_Homo sapiens_hsa030100.93942834
86GnRH signaling pathway_Homo sapiens_hsa049120.93434149
87Sulfur metabolism_Homo sapiens_hsa009200.92533367
88Pancreatic secretion_Homo sapiens_hsa049720.90601335
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.89193526
90Collecting duct acid secretion_Homo sapiens_hsa049660.88388637
91Phototransduction_Homo sapiens_hsa047440.88223465
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83653038
93Bile secretion_Homo sapiens_hsa049760.81983328
94Primary immunodeficiency_Homo sapiens_hsa053400.80444562
95Fat digestion and absorption_Homo sapiens_hsa049750.80249972
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79083871
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75799181
98Glycerolipid metabolism_Homo sapiens_hsa005610.74617862
99Galactose metabolism_Homo sapiens_hsa000520.73209741
100Inositol phosphate metabolism_Homo sapiens_hsa005620.72824410
101Proteasome_Homo sapiens_hsa030500.71248164
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70732959
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69685182
104mTOR signaling pathway_Homo sapiens_hsa041500.69256430
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68241945
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65675613
107Purine metabolism_Homo sapiens_hsa002300.65277483
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.64468310
109Thyroid hormone synthesis_Homo sapiens_hsa049180.61710881
110Metabolic pathways_Homo sapiens_hsa011000.61069221
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60983321
112Histidine metabolism_Homo sapiens_hsa003400.58877930
113Glucagon signaling pathway_Homo sapiens_hsa049220.58497585
114Estrogen signaling pathway_Homo sapiens_hsa049150.56827713
115Cocaine addiction_Homo sapiens_hsa050300.56673195
116Carbon metabolism_Homo sapiens_hsa012000.56279456
117beta-Alanine metabolism_Homo sapiens_hsa004100.55979474
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53440220
119MAPK signaling pathway_Homo sapiens_hsa040100.52585744
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50817871
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50437558
122Asthma_Homo sapiens_hsa053100.49920475
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.49756733
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49217978
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49176057
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46565429
127Choline metabolism in cancer_Homo sapiens_hsa052310.44962656
128Pyrimidine metabolism_Homo sapiens_hsa002400.44916831
129Nucleotide excision repair_Homo sapiens_hsa034200.44670428
130Oocyte meiosis_Homo sapiens_hsa041140.44591969
131AMPK signaling pathway_Homo sapiens_hsa041520.44139829
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44137865
133Dorso-ventral axis formation_Homo sapiens_hsa043200.44069826
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.44057796
135HIF-1 signaling pathway_Homo sapiens_hsa040660.42330540
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41892642
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41485513
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.39711327
139Vitamin digestion and absorption_Homo sapiens_hsa049770.39218147
140Steroid biosynthesis_Homo sapiens_hsa001000.38302269
141Vitamin B6 metabolism_Homo sapiens_hsa007500.37531990
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34548308
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34353932
144Renal cell carcinoma_Homo sapiens_hsa052110.33956070
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33872248
146Fatty acid degradation_Homo sapiens_hsa000710.32797305
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32698357
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32232706
149Type I diabetes mellitus_Homo sapiens_hsa049400.31589663
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29714628
151Nitrogen metabolism_Homo sapiens_hsa009100.29556678
152ABC transporters_Homo sapiens_hsa020100.28686975
153Ovarian steroidogenesis_Homo sapiens_hsa049130.27639384
154Alcoholism_Homo sapiens_hsa050340.27049789
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26935885
156Vibrio cholerae infection_Homo sapiens_hsa051100.26912696
157Endometrial cancer_Homo sapiens_hsa052130.26557599
158ErbB signaling pathway_Homo sapiens_hsa040120.25605798
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24662198
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23644634
161Endocytosis_Homo sapiens_hsa041440.23500246
162Insulin signaling pathway_Homo sapiens_hsa049100.21413868
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20464424
164Fatty acid biosynthesis_Homo sapiens_hsa000610.20096384
165Pyruvate metabolism_Homo sapiens_hsa006200.18748750
166Axon guidance_Homo sapiens_hsa043600.18655612
167Melanogenesis_Homo sapiens_hsa049160.17990142
168Ras signaling pathway_Homo sapiens_hsa040140.17452649
169Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17281870
170Glioma_Homo sapiens_hsa052140.16961383

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