KCNH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by virus of host process (GO:0019054)8.80609004
2detection of calcium ion (GO:0005513)8.42527695
3modulation by symbiont of host cellular process (GO:0044068)6.94574652
4adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.84453505
5negative regulation of catenin import into nucleus (GO:0035414)6.16487345
6sensory perception of smell (GO:0007608)5.66643513
7layer formation in cerebral cortex (GO:0021819)5.18638522
8neuronal action potential (GO:0019228)5.12997776
9cellular response to virus (GO:0098586)5.02835909
10nerve growth factor signaling pathway (GO:0038180)5.01635270
11response to auditory stimulus (GO:0010996)4.98153136
12G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.83604196
13exploration behavior (GO:0035640)4.81575746
14cellular response to glucagon stimulus (GO:0071377)4.80408035
15neurotransmitter-gated ion channel clustering (GO:0072578)4.61854584
16positive regulation of dendritic spine morphogenesis (GO:0061003)4.59319880
17positive regulation of synapse maturation (GO:0090129)4.55902051
18negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.55060112
19negative regulation of execution phase of apoptosis (GO:1900118)4.54632076
20calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.48498698
21venous blood vessel morphogenesis (GO:0048845)4.42055007
22modulation by virus of host morphology or physiology (GO:0019048)4.40790311
23dopamine receptor signaling pathway (GO:0007212)4.32207850
24sensory perception of chemical stimulus (GO:0007606)4.30599088
25morphogenesis of an endothelium (GO:0003159)4.30332415
26endothelial tube morphogenesis (GO:0061154)4.30332415
27protein insertion into membrane (GO:0051205)4.28805590
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18402221
29regulation of ARF protein signal transduction (GO:0032012)4.12787420
30negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.11845411
31protein localization to cilium (GO:0061512)4.10018195
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98774893
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86973084
34pericardium development (GO:0060039)3.86044974
35regulation of synapse structural plasticity (GO:0051823)3.85227514
36negative regulation of erythrocyte differentiation (GO:0045647)3.83951467
37regulation of telomere maintenance via telomerase (GO:0032210)3.82465280
38negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.78308800
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78114614
40mating behavior (GO:0007617)3.76092755
41neuron cell-cell adhesion (GO:0007158)3.75977790
42regulation of synapse maturation (GO:0090128)3.74998087
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.72146415
44neurotransmitter secretion (GO:0007269)3.71975332
45synaptic vesicle maturation (GO:0016188)3.70171961
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69205444
47positive regulation of dendritic spine development (GO:0060999)3.68239076
48vocalization behavior (GO:0071625)3.61010725
49prepulse inhibition (GO:0060134)3.60531221
50regulation of protein targeting to membrane (GO:0090313)3.58925714
51cerebellar granule cell differentiation (GO:0021707)3.57362698
52neuromuscular process controlling posture (GO:0050884)3.55662214
53neuronal ion channel clustering (GO:0045161)3.55244090
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.53815891
55positive regulation of membrane potential (GO:0045838)3.53450189
56positive regulation of Rap GTPase activity (GO:0032854)3.52499955
57dendritic spine morphogenesis (GO:0060997)3.50789146
58locomotory exploration behavior (GO:0035641)3.49973800
59response to glucagon (GO:0033762)3.49241289
60response to muramyl dipeptide (GO:0032495)3.44568724
61cellular response to prostaglandin stimulus (GO:0071379)3.43910485
62regulation of glutamate receptor signaling pathway (GO:1900449)3.43788755
63regulation of Rap GTPase activity (GO:0032317)3.42327580
64cAMP catabolic process (GO:0006198)3.38733142
65axonal fasciculation (GO:0007413)3.36108194
66iron-sulfur cluster assembly (GO:0016226)3.34218776
67metallo-sulfur cluster assembly (GO:0031163)3.34218776
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28467022
69neuron recognition (GO:0008038)3.28408230
70response to amphetamine (GO:0001975)3.28023297
71cell differentiation in hindbrain (GO:0021533)3.26998748
72auditory behavior (GO:0031223)3.26661823
73negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24484975
74regulation of synaptic vesicle exocytosis (GO:2000300)3.23983771
75regulation of neuronal synaptic plasticity (GO:0048168)3.21863237
76synaptic vesicle exocytosis (GO:0016079)3.19464382
77regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.19379340
78mitochondrion transport along microtubule (GO:0047497)3.16582071
79establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16582071
80regulation of neurotransmitter secretion (GO:0046928)3.14626128
81Peyers patch development (GO:0048541)3.14614329
82mucosal-associated lymphoid tissue development (GO:0048537)3.14614329
83microtubule bundle formation (GO:0001578)3.14018370
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13197949
85regulation of voltage-gated calcium channel activity (GO:1901385)3.11395970
86striatum development (GO:0021756)3.10467563
87cellular potassium ion homeostasis (GO:0030007)3.09973455
88establishment of mitochondrion localization (GO:0051654)3.09015795
89ADP metabolic process (GO:0046031)3.08908199
90synaptic vesicle docking involved in exocytosis (GO:0016081)3.07848181
91activation of MAPKKK activity (GO:0000185)3.06817881
92synaptic transmission, dopaminergic (GO:0001963)3.06693818
93glutamate secretion (GO:0014047)3.03101409
94cyclic nucleotide catabolic process (GO:0009214)3.00295535
95neurofilament cytoskeleton organization (GO:0060052)3.00275888
96synaptic vesicle endocytosis (GO:0048488)2.99783077
97regulation of synaptic plasticity (GO:0048167)2.99196651
98negative regulation of dendrite morphogenesis (GO:0050774)2.99132852
99response to peptidoglycan (GO:0032494)2.98345048
100behavioral response to cocaine (GO:0048148)2.97107200
101cell migration in hindbrain (GO:0021535)2.96809571
102response to nerve growth factor (GO:1990089)2.96135084
103cellular response to nerve growth factor stimulus (GO:1990090)2.96135084
104regulation of protein kinase A signaling (GO:0010738)2.95637807
105positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.95341695
106negative regulation of anoikis (GO:2000811)2.94490712
107positive regulation of CREB transcription factor activity (GO:0032793)2.93164912
108neurotransmitter transport (GO:0006836)2.92976860
109sensory perception of taste (GO:0050909)2.92080920
110regulation of G0 to G1 transition (GO:0070316)2.90499915
111positive regulation of neurotransmitter transport (GO:0051590)2.90459781
112neuronal action potential propagation (GO:0019227)2.86152234
113response to gravity (GO:0009629)2.86081787
114serotonin metabolic process (GO:0042428)2.85995372
115regulation of synaptic vesicle transport (GO:1902803)2.85258435
116postsynaptic membrane organization (GO:0001941)2.85221061
117glutathione biosynthetic process (GO:0006750)2.84943147
118snRNA transcription (GO:0009301)2.82857432
119positive regulation of neurotransmitter secretion (GO:0001956)2.82788775
120long-term memory (GO:0007616)2.81862952
121cerebellar Purkinje cell differentiation (GO:0021702)2.81170467
122neuromuscular process controlling balance (GO:0050885)2.80843660
123ionotropic glutamate receptor signaling pathway (GO:0035235)2.80692542
124regulation of regulated secretory pathway (GO:1903305)2.80070564
125Rap protein signal transduction (GO:0032486)2.79751260
126activation of protein kinase A activity (GO:0034199)2.79523134
127protein localization to synapse (GO:0035418)2.79462600
128action potential (GO:0001508)2.79064753
129regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78553688
130regulation of gamma-delta T cell differentiation (GO:0045586)2.77542382
131synaptic transmission, glutamatergic (GO:0035249)2.77504936
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76573909
133regulation of respiratory gaseous exchange (GO:0043576)2.76011891
134release of cytochrome c from mitochondria (GO:0001836)2.75402604
135negative regulation of Ras GTPase activity (GO:0034261)2.74190547
136cellular response to monoamine stimulus (GO:0071868)2.74075447
137cellular response to catecholamine stimulus (GO:0071870)2.74075447
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73124702
139regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.72617181
140regulation of gamma-delta T cell activation (GO:0046643)2.70076594
141germinal center formation (GO:0002467)2.69618197
142negative regulation of interleukin-12 production (GO:0032695)2.67882053
143regulation of glycogen (starch) synthase activity (GO:2000465)2.66452907
144histone H3-K4 trimethylation (GO:0080182)2.65304486
145regulation of neurotransmitter transport (GO:0051588)2.64389405
146negative regulation of toll-like receptor signaling pathway (GO:0034122)2.60657622
147regulation of dendritic spine morphogenesis (GO:0061001)2.60269123
148regulation of postsynaptic membrane potential (GO:0060078)2.58578402
149chemosensory behavior (GO:0007635)2.58019295
150positive regulation of gamma-delta T cell activation (GO:0046645)2.57770898
151glucocorticoid receptor signaling pathway (GO:0042921)2.56369115
152regulation of neurotransmitter levels (GO:0001505)2.55774425
153regulation of respiratory system process (GO:0044065)2.54846099
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54620917
155membrane depolarization during action potential (GO:0086010)2.54074886
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53747859
157negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53720537
158proline transport (GO:0015824)2.53097612
159neuron-neuron synaptic transmission (GO:0007270)2.49677145
160neutrophil activation (GO:0042119)2.48841445
161regulation of synaptic transmission (GO:0050804)2.44087348
162primary amino compound metabolic process (GO:1901160)2.43452250
163regulation of telomerase activity (GO:0051972)2.43400811
164response to manganese ion (GO:0010042)2.42747563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.84581041
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.98899095
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.41427185
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.58860000
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.28969798
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.28210452
7MYC_22102868_ChIP-Seq_BL_Human3.01479831
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.88564640
9DROSHA_22980978_ChIP-Seq_HELA_Human2.69165218
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64421558
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.54424811
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51318064
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51318064
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51291105
15VDR_21846776_ChIP-Seq_THP-1_Human2.48700180
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45677295
17LXR_22292898_ChIP-Seq_THP-1_Human2.38687686
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34581617
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22591387
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.19603391
21REST_21632747_ChIP-Seq_MESCs_Mouse2.18633062
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17386124
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.15858578
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.14915463
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13377948
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12241970
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11994436
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.10852585
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10752401
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07118390
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02978524
32GBX2_23144817_ChIP-Seq_PC3_Human1.99253568
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97102850
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91053196
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.90536579
36KDM2B_26808549_Chip-Seq_K562_Human1.89183443
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85190612
38TCF7_22412390_ChIP-Seq_EML_Mouse1.81222514
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.78581158
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78384882
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78366935
42SCL_19346495_ChIP-Seq_HPC-7_Human1.78165236
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.76097012
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72925707
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63112033
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62233582
47* MAF_26560356_Chip-Seq_TH1_Human1.61603091
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60184771
49P68_20966046_ChIP-Seq_HELA_Human1.59051881
50SPI1_23127762_ChIP-Seq_K562_Human1.53660863
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.53545284
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52644414
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51487526
54VDR_24763502_ChIP-Seq_THP-1_Human1.49437731
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44405132
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40163799
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.40016489
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39811822
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39669078
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38310426
61UTX_26944678_Chip-Seq_JUKART_Human1.36947694
62SA1_27219007_Chip-Seq_Bcells_Human1.34196756
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31454390
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29695010
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29067744
66* BCOR_27268052_Chip-Seq_Bcells_Human1.28915205
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28537071
68MAF_26560356_Chip-Seq_TH2_Human1.27980829
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.27627287
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.26979307
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.26175578
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.25807811
73CTCF_27219007_Chip-Seq_Bcells_Human1.24751258
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23498501
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23145098
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21519130
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21406090
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.20334218
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18762341
80* BCL6_27268052_Chip-Seq_Bcells_Human1.18322700
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18124030
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17040978
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16256718
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15118043
85AHR_22903824_ChIP-Seq_MCF-7_Human1.14149746
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13959006
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12682882
88* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11100956
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10894854
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09973867
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.09835238
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09594264
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09215758
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.09101013
95* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08715320
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07499906
97CREB1_26743006_Chip-Seq_LNCaP_Human1.06237248
98ETS1_21867929_ChIP-Seq_TH2_Mouse1.04251435
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03876890
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.03800455
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03346115
102SMAD4_21799915_ChIP-Seq_A2780_Human1.02541363
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01904530
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00687099
105DPY_21335234_ChIP-Seq_ESCs_Mouse1.00457227
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.99821756
107AR_19668381_ChIP-Seq_PC3_Human0.98297143
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97772269
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97646088
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97428725
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.97170218
112WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97142333
113CBX2_27304074_Chip-Seq_ESCs_Mouse0.96553919
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96395280
115RUNX_20019798_ChIP-Seq_JUKART_Human0.95658376
116GATA1_19941826_ChIP-Seq_K562_Human0.95542004
117E2F7_22180533_ChIP-Seq_HELA_Human0.95413317
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95231333
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95118094
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95050768
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93624165
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93388089
123* KLF4_19829295_ChIP-Seq_ESCs_Human0.92179112
124* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92134523
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91883591
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91840987
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91624059
128ZNF274_21170338_ChIP-Seq_K562_Hela0.91347151
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89445170
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89445170
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88404803
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88342075
133AR_21572438_ChIP-Seq_LNCaP_Human0.86502837
134OCT4_19829295_ChIP-Seq_ESCs_Human0.86360280
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85313016
136KDM2B_26808549_Chip-Seq_DND41_Human0.83626936
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.83241237
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.81363172
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81309220
140WDR5_24793694_ChIP-Seq_LNCAP_Human0.80860784
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80219915
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79908563
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.78227713
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77585747
145P300_19829295_ChIP-Seq_ESCs_Human0.76947710
146TAF15_26573619_Chip-Seq_HEK293_Human0.76792284
147RUNX2_22187159_ChIP-Seq_PCA_Human0.76544964
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75653297
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.75398067
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75370240
151SMC4_20622854_ChIP-Seq_HELA_Human0.74768941
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74042351
153ELF1_20517297_ChIP-Seq_JURKAT_Human0.74034362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.76248662
2MP0004859_abnormal_synaptic_plasticity5.47849722
3MP0002822_catalepsy4.76733876
4MP0003878_abnormal_ear_physiology3.77551281
5MP0005377_hearing/vestibular/ear_phenot3.77551281
6MP0004270_analgesia3.67573148
7MP0003635_abnormal_synaptic_transmissio3.47020471
8MP0003880_abnormal_central_pattern3.25369316
9MP0004858_abnormal_nervous_system3.00041876
10MP0002063_abnormal_learning/memory/cond2.82596627
11MP0009745_abnormal_behavioral_response2.72164759
12MP0003787_abnormal_imprinting2.69542100
13MP0005645_abnormal_hypothalamus_physiol2.64990932
14MP0001348_abnormal_lacrimal_gland2.64769197
15MP0001486_abnormal_startle_reflex2.60247019
16MP0005423_abnormal_somatic_nervous2.53636416
17MP0005499_abnormal_olfactory_system2.50234660
18MP0005394_taste/olfaction_phenotype2.50234660
19MP0002064_seizures2.38449568
20MP0002572_abnormal_emotion/affect_behav2.35415944
21MP0001485_abnormal_pinna_reflex2.32429394
22MP0000015_abnormal_ear_pigmentation2.32046039
23MP0005646_abnormal_pituitary_gland2.25339278
24MP0009278_abnormal_bone_marrow2.24306070
25MP0003303_peritoneal_inflammation2.14606223
26MP0008789_abnormal_olfactory_epithelium2.13133037
27MP0003436_decreased_susceptibility_to2.08207443
28MP0005451_abnormal_body_composition2.06935909
29MP0008877_abnormal_DNA_methylation2.05067562
30MP0002272_abnormal_nervous_system2.04165549
31MP0003724_increased_susceptibility_to1.94831878
32MP0002184_abnormal_innervation1.93652530
33MP0009046_muscle_twitch1.92731676
34MP0004510_myositis1.92019189
35MP0003646_muscle_fatigue1.89826019
36MP0000778_abnormal_nervous_system1.85358010
37MP0010386_abnormal_urinary_bladder1.84721946
38MP0001529_abnormal_vocalization1.81941560
39MP0004811_abnormal_neuron_physiology1.75618350
40MP0005167_abnormal_blood-brain_barrier1.72552738
41MP0002557_abnormal_social/conspecific_i1.72321139
42MP0001968_abnormal_touch/_nociception1.71134270
43MP0005000_abnormal_immune_tolerance1.69813719
44MP0002734_abnormal_mechanical_nocicepti1.67985095
45MP0003123_paternal_imprinting1.61905874
46MP0010352_gastrointestinal_tract_polyps1.54773173
47MP0004130_abnormal_muscle_cell1.51970588
48MP0004185_abnormal_adipocyte_glucose1.51124593
49MP0002735_abnormal_chemical_nociception1.48956969
50MP0002882_abnormal_neuron_morphology1.47570678
51MP0006276_abnormal_autonomic_nervous1.47539565
52MP0001970_abnormal_pain_threshold1.46102944
53MP0002160_abnormal_reproductive_system1.43942974
54MP0001905_abnormal_dopamine_level1.40675339
55MP0002152_abnormal_brain_morphology1.36196460
56MP0004233_abnormal_muscle_weight1.34490138
57MP0003329_amyloid_beta_deposits1.33493964
58MP0003172_abnormal_lysosome_physiology1.31022995
59MP0002723_abnormal_immune_serum1.30588480
60MP0002909_abnormal_adrenal_gland1.29604523
61MP0005310_abnormal_salivary_gland1.29403345
62MP0001800_abnormal_humoral_immune1.24696099
63MP0005671_abnormal_response_to1.24116915
64MP0002148_abnormal_hypersensitivity_rea1.22025358
65MP0002420_abnormal_adaptive_immunity1.22012979
66MP0005025_abnormal_response_to1.21982312
67MP0002067_abnormal_sensory_capabilities1.21781211
68MP0003075_altered_response_to1.19908297
69MP0001819_abnormal_immune_cell1.19618436
70MP0001501_abnormal_sleep_pattern1.18844920
71MP0005623_abnormal_meninges_morphology1.16442196
72MP0005076_abnormal_cell_differentiation1.15719564
73MP0005386_behavior/neurological_phenoty1.15032980
74MP0004924_abnormal_behavior1.15032980
75MP0000003_abnormal_adipose_tissue1.14715329
76MP0001835_abnormal_antigen_presentation1.14196416
77MP0002398_abnormal_bone_marrow1.14050206
78MP0008569_lethality_at_weaning1.13522640
79MP0002452_abnormal_antigen_presenting1.12911809
80MP0005387_immune_system_phenotype1.11062634
81MP0001790_abnormal_immune_system1.11062634
82MP0001188_hyperpigmentation1.10502564
83MP0003763_abnormal_thymus_physiology1.10111820
84MP0002733_abnormal_thermal_nociception1.09954434
85MP0002066_abnormal_motor_capabilities/c1.09317496
86MP0002419_abnormal_innate_immunity1.08735959
87MP0000013_abnormal_adipose_tissue1.08734685
88MP0009333_abnormal_splenocyte_physiolog1.07858483
89MP0000685_abnormal_immune_system1.07099929
90MP0002127_abnormal_cardiovascular_syste1.06483885
91MP0001502_abnormal_circadian_rhythm1.04675364
92MP0000955_abnormal_spinal_cord1.04646002
93MP0000537_abnormal_urethra_morphology1.01967866
94MP0001963_abnormal_hearing_physiology1.01659019
95MP0002752_abnormal_somatic_nervous1.00450754
96MP0000716_abnormal_immune_system1.00104521
97MP0000678_abnormal_parathyroid_gland0.98524207
98MP0004782_abnormal_surfactant_physiolog0.97750157
99MP0003631_nervous_system_phenotype0.95503553
100MP0008961_abnormal_basal_metabolism0.95093763
101MP0000569_abnormal_digit_pigmentation0.94993491
102MP0004885_abnormal_endolymph0.94403373
103MP0000604_amyloidosis0.93618132
104MP0005397_hematopoietic_system_phenotyp0.93529767
105MP0001545_abnormal_hematopoietic_system0.93529767
106MP0002069_abnormal_eating/drinking_beha0.91178971
107MP0000631_abnormal_neuroendocrine_gland0.90555649
108MP0008874_decreased_physiological_sensi0.89847972
109MP0003252_abnormal_bile_duct0.87796914
110MP0000026_abnormal_inner_ear0.86930753
111MP0001533_abnormal_skeleton_physiology0.86676513
112MP0002229_neurodegeneration0.86185407
113MP0003879_abnormal_hair_cell0.86092647
114MP0003861_abnormal_nervous_system0.85291988
115MP0009785_altered_susceptibility_to0.84126702
116MP0002736_abnormal_nociception_after0.82565019
117MP0003195_calcinosis0.81879226
118MP0002653_abnormal_ependyma_morphology0.81335768
119MP0002429_abnormal_blood_cell0.79219662
120MP0000751_myopathy0.77503125
121MP0004742_abnormal_vestibular_system0.76297578
122MP0003121_genomic_imprinting0.76058193
123MP0005171_absent_coat_pigmentation0.75564564
124MP0000703_abnormal_thymus_morphology0.74484246
125MP0002722_abnormal_immune_system0.74333307
126MP0003283_abnormal_digestive_organ0.74010739
127MP0008872_abnormal_physiological_respon0.73265767
128MP0009764_decreased_sensitivity_to0.72545358
129MP0000467_abnormal_esophagus_morphology0.72150511
130MP0002163_abnormal_gland_morphology0.71200852
131MP0001845_abnormal_inflammatory_respons0.71070814
132MP0000920_abnormal_myelination0.70768070
133MP0000689_abnormal_spleen_morphology0.69944034
134MP0002928_abnormal_bile_duct0.68574866
135MP0002638_abnormal_pupillary_reflex0.68508067
136MP0001440_abnormal_grooming_behavior0.67201470
137MP0002095_abnormal_skin_pigmentation0.66986102
138MP0003045_fibrosis0.66443364
139MP0003633_abnormal_nervous_system0.66024273
140MP0001177_atelectasis0.65384641
141MP0009780_abnormal_chondrocyte_physiolo0.61630070
142MP0003632_abnormal_nervous_system0.60930694
143MP0005535_abnormal_body_temperature0.60813610
144MP0003634_abnormal_glial_cell0.59763488
145MP0002081_perinatal_lethality0.58841782
146MP0003122_maternal_imprinting0.58547671
147MP0005187_abnormal_penis_morphology0.54463740
148MP0000538_abnormal_urinary_bladder0.54038750
149MP0000534_abnormal_ureter_morphology0.53005963
150MP0002082_postnatal_lethality0.52863282
151MP0010770_preweaning_lethality0.52863282
152MP0003690_abnormal_glial_cell0.51647199
153MP0001943_abnormal_respiration0.51416809
154MP0004085_abnormal_heartbeat0.51336932
155MP0001186_pigmentation_phenotype0.51183333
156MP0010769_abnormal_survival0.51079471

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.11875531
2Focal seizures (HP:0007359)4.60840104
3Limb dystonia (HP:0002451)4.56795650
4Focal motor seizures (HP:0011153)4.52157820
5Scanning speech (HP:0002168)4.43208402
6Ankle clonus (HP:0011448)3.94517928
7Febrile seizures (HP:0002373)3.90367528
8Truncal ataxia (HP:0002078)3.80398549
9Torticollis (HP:0000473)3.79884285
10Anosmia (HP:0000458)3.61308893
11Retinal dysplasia (HP:0007973)3.53253180
12Atonic seizures (HP:0010819)3.29293315
13Segmental peripheral demyelination/remyelination (HP:0003481)3.28387258
14Focal dystonia (HP:0004373)3.20398866
15Optic neuritis (HP:0100653)3.14756853
16Retrobulbar optic neuritis (HP:0100654)3.14756853
17Broad-based gait (HP:0002136)3.11094759
18Craniofacial dystonia (HP:0012179)3.09609444
19Poor eye contact (HP:0000817)3.08616311
20Postural instability (HP:0002172)3.06765703
21Polygenic inheritance (HP:0010982)3.03677958
22Abnormal hair whorl (HP:0010721)3.01783798
23Narrow nasal bridge (HP:0000446)3.00488621
24Diplopia (HP:0000651)2.98238383
25Abnormality of binocular vision (HP:0011514)2.98238383
26Pointed chin (HP:0000307)2.95837196
27Hyperventilation (HP:0002883)2.92634437
28Neoplasm of the adrenal cortex (HP:0100641)2.86606331
29Cerebral aneurysm (HP:0004944)2.85470928
30Orchitis (HP:0100796)2.82458694
31Insomnia (HP:0100785)2.76821919
32Fetal akinesia sequence (HP:0001989)2.74640745
33Visual hallucinations (HP:0002367)2.72976360
34Abnormality of the diencephalon (HP:0010662)2.72765409
35Clonus (HP:0002169)2.72581238
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70151049
37Inability to walk (HP:0002540)2.67609759
38Stereotypic behavior (HP:0000733)2.66360679
39Generalized tonic-clonic seizures (HP:0002069)2.66236845
40Dysphonia (HP:0001618)2.63449534
41Bowel diverticulosis (HP:0005222)2.63182780
42Abnormal social behavior (HP:0012433)2.63037963
43Impaired social interactions (HP:0000735)2.63037963
44Peripheral hypomyelination (HP:0007182)2.62250438
45Epileptic encephalopathy (HP:0200134)2.60287705
46Absence seizures (HP:0002121)2.58210458
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.54177396
48Elfin facies (HP:0004428)2.50857334
49Gait imbalance (HP:0002141)2.50465913
50Neuronal loss in central nervous system (HP:0002529)2.49852661
51High anterior hairline (HP:0009890)2.49446848
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49069223
53Increased cerebral lipofuscin (HP:0011813)2.45982013
54Septate vagina (HP:0001153)2.44516083
55Dysmetria (HP:0001310)2.44041131
56Specific learning disability (HP:0001328)2.43417407
57Syncope (HP:0001279)2.40628080
58Exotropia (HP:0000577)2.40197922
59Renovascular hypertension (HP:0100817)2.40066879
60Hypoplasia of the iris (HP:0007676)2.38531085
61Polyphagia (HP:0002591)2.34561727
62Impaired smooth pursuit (HP:0007772)2.31916970
63Abnormal respiratory motile cilium morphology (HP:0005938)2.31910352
64Abnormal respiratory epithelium morphology (HP:0012253)2.31910352
65Tetraplegia (HP:0002445)2.31240397
66Abnormal ciliary motility (HP:0012262)2.29993865
67Spinal canal stenosis (HP:0003416)2.27623676
68Sleep apnea (HP:0010535)2.25665379
69Annular pancreas (HP:0001734)2.23674124
70Blue irides (HP:0000635)2.23316413
71Hyperacusis (HP:0010780)2.22997858
72Bradykinesia (HP:0002067)2.22919014
73Myositis (HP:0100614)2.20943433
74Status epilepticus (HP:0002133)2.20552896
75Amblyopia (HP:0000646)2.20234852
76Supranuclear gaze palsy (HP:0000605)2.20036304
77Methylmalonic acidemia (HP:0002912)2.20026431
78Depression (HP:0000716)2.19206870
79Action tremor (HP:0002345)2.19108321
80Impaired vibration sensation in the lower limbs (HP:0002166)2.17473278
81Urinary urgency (HP:0000012)2.17063753
82Gastrointestinal stroma tumor (HP:0100723)2.15696093
83Abnormal respiratory motile cilium physiology (HP:0012261)2.15633339
84Abnormal eating behavior (HP:0100738)2.14673006
85Dialeptic seizures (HP:0011146)2.14493295
86Abnormality of homocysteine metabolism (HP:0010919)2.13854116
87Homocystinuria (HP:0002156)2.13854116
88Medial flaring of the eyebrow (HP:0010747)2.13471806
89Cystic liver disease (HP:0006706)2.13358037
90Bundle branch block (HP:0011710)2.12884664
91Obstructive sleep apnea (HP:0002870)2.12733249
92Abnormality of the lower motor neuron (HP:0002366)2.12724788
93Autoimmune thrombocytopenia (HP:0001973)2.10988555
94Congenital primary aphakia (HP:0007707)2.10461333
95Gaze-evoked nystagmus (HP:0000640)2.10371765
96Dysmetric saccades (HP:0000641)2.08511696
97Urinary bladder sphincter dysfunction (HP:0002839)2.08113158
98Excessive salivation (HP:0003781)2.07882615
99Drooling (HP:0002307)2.07882615
100Absent speech (HP:0001344)2.06554922
101Sudden death (HP:0001699)2.04453653
102Lower limb muscle weakness (HP:0007340)2.03648929
103Stroke (HP:0001297)2.03457033
104Mutism (HP:0002300)2.02675944
105Megalencephaly (HP:0001355)2.01173593
106Sclerocornea (HP:0000647)2.01062430
107Abdominal situs inversus (HP:0003363)1.99908704
108Abnormality of abdominal situs (HP:0011620)1.99908704
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99305909
110Papilledema (HP:0001085)1.98320087
111Oligodontia (HP:0000677)1.95033337
112Insidious onset (HP:0003587)1.94598692
113Termporal pattern (HP:0011008)1.94598692
114Spastic paraplegia (HP:0001258)1.93502966
115Dysautonomia (HP:0002459)1.92859369
116Nephrogenic diabetes insipidus (HP:0009806)1.90611346
117Persistence of primary teeth (HP:0006335)1.90381124
118Prolonged QT interval (HP:0001657)1.90259344
119Epileptiform EEG discharges (HP:0011182)1.89737218
120Failure to thrive in infancy (HP:0001531)1.89219806
121Overriding aorta (HP:0002623)1.88839408
122Vertigo (HP:0002321)1.88561226
123Acute lymphatic leukemia (HP:0006721)1.88465513
124Anxiety (HP:0000739)1.87438590
125Diminished motivation (HP:0000745)1.86992452
126Spastic gait (HP:0002064)1.86922192
127Abnormality of ocular smooth pursuit (HP:0000617)1.85782930
128Tented upper lip vermilion (HP:0010804)1.85588735
129Submucous cleft hard palate (HP:0000176)1.83702901
130Memory impairment (HP:0002354)1.82573703
131Genetic anticipation (HP:0003743)1.82543323
132Abnormality of saccadic eye movements (HP:0000570)1.82194142
133Hemiparesis (HP:0001269)1.82129154
134Rhinitis (HP:0012384)1.82023865
135Paraplegia (HP:0010550)1.81899790
136Abnormality of salivation (HP:0100755)1.81295699
137Neurodegeneration (HP:0002180)1.80856946
138Ulnar claw (HP:0001178)1.80784991
139Progressive cerebellar ataxia (HP:0002073)1.80385272
140Growth hormone excess (HP:0000845)1.80271090
141Keratoconjunctivitis sicca (HP:0001097)1.79397272
142Autism (HP:0000717)1.79265299
143Agnosia (HP:0010524)1.78628183
144Methylmalonic aciduria (HP:0012120)1.76668699
145Athetosis (HP:0002305)1.75725957
146Aplasia/Hypoplasia of the lens (HP:0008063)1.75640815
147Abnormality of the columella (HP:0009929)1.75221260
148Recurrent bacterial skin infections (HP:0005406)1.72670413
149Onion bulb formation (HP:0003383)1.71550420
150Hypercortisolism (HP:0001578)1.70786585
151Hypsarrhythmia (HP:0002521)1.70702855
152EEG with generalized epileptiform discharges (HP:0011198)1.69784003
153Vasculitis (HP:0002633)1.69017700
154Intention tremor (HP:0002080)1.66936682
155Psychosis (HP:0000709)1.65514713
156Slow saccadic eye movements (HP:0000514)1.64224124
157Epiphyseal dysplasia (HP:0002656)1.62219771
158Limb ataxia (HP:0002070)1.59514743
159Increased IgE level (HP:0003212)1.58901332
160Ocular albinism (HP:0001107)1.57822888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK17.13534614
2ARAF7.01132328
3PIM23.74375822
4IRAK33.51548017
5EPHA43.42815265
6BRAF2.71969455
7MAP3K142.35651453
8TAOK12.33998391
9PRKD32.30705236
10RAF12.28644748
11MARK12.25490858
12PRPF4B2.19229186
13MAP4K11.94503239
14TAOK21.93109449
15TYRO31.91431170
16MAP3K131.90782209
17TAOK31.83176693
18DDR21.77614183
19DAPK21.76954843
20CAMK1D1.71000565
21NTRK31.63100644
22ICK1.55687530
23MARK21.52976893
24MAP3K91.52332081
25MINK11.49203365
26NTRK21.49191370
27MAP2K71.47993840
28DMPK1.41674727
29MAP3K41.37932144
30CASK1.27787293
31IRAK41.24692065
32PRKCH1.23352071
33ERN11.22458313
34PLK31.19541531
35TNK21.19290000
36BCKDK1.15872312
37PAK61.13974186
38MAPK131.13081242
39IRAK21.12927190
40FGR1.10881855
41KSR11.09217644
42PINK11.05035400
43MATK1.01148046
44SIK20.99702469
45GRK50.96868679
46CAMKK10.96342822
47CDK50.91663997
48PLK20.89438295
49SYK0.86627650
50PDK10.86564590
51RPS6KA20.86071952
52TNIK0.85201573
53UHMK10.82411782
54TBK10.82057229
55CAMK2G0.81490706
56CAMKK20.80168951
57MAP3K110.80008985
58GRK60.79851990
59KSR20.79304650
60TXK0.79167876
61PHKG20.78808102
62PHKG10.78808102
63MAP2K40.78467424
64BMPR1B0.77732915
65PDGFRA0.76860460
66JAK30.74340399
67CSNK1A1L0.73712846
68CSNK1G20.73637960
69STK380.72744937
70ERBB30.72709003
71RIPK40.72629145
72IKBKE0.71727246
73CAMK2B0.71581526
74EEF2K0.71394416
75CSK0.70544887
76CAMK1G0.68911532
77MAPK120.66780611
78JAK20.66608779
79MAP2K60.65595500
80STK110.64119686
81DAPK10.63321072
82IKBKB0.63204036
83TRIB30.62579787
84FES0.62119425
85PDPK10.61386445
86BTK0.61239120
87CSNK1G30.58111687
88PNCK0.58067322
89CDC42BPA0.57182306
90CCNB10.56217907
91CDK120.54882103
92CSF1R0.54250070
93PRKCE0.52605573
94MAP3K30.50918494
95SIK30.50010039
96TYK20.49574182
97KIT0.49315149
98HCK0.48924832
99PIM10.46745976
100CHUK0.46338955
101PRKCI0.45769859
102CDK180.45276225
103JAK10.43763119
104HIPK20.42557221
105RPS6KA10.41315358
106FGFR20.40938602
107MAP3K60.40848617
108CDK150.40672314
109EPHB20.40665390
110SGK2230.40403191
111SGK4940.40403191
112MAP3K10.39981264
113MAP3K20.38962559
114ITK0.38881009
115CAMK2D0.38739116
116PRKCQ0.38081949
117TESK20.38048292
118MAP2K20.37687484
119MAPK40.37580871
120ZAP700.37566948
121CSNK1G10.36967442
122BMPR20.36955752
123NTRK10.36520846
124CDK140.35934035
125RPS6KA60.35892261
126FYN0.34394900
127LCK0.34083102
128PRKCZ0.33509170
129DAPK30.33140095
130MAPK90.33006619
131MAP2K30.32599643
132MAPK80.32524749
133PRKCG0.32372912
134PAK30.31171962
135PRKD20.30631234
136CDK11A0.30448827
137CAMK10.29999266
138SGK20.29738834
139CAMK2A0.29572741
140ZAK0.29367004
141MAPK100.29143921
142DYRK20.29098334
143RET0.29032526
144CAMK40.28995367
145ALK0.27970437
146RPS6KC10.26454307
147RPS6KL10.26454307
148PRKD10.26143748

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.56061568
2Morphine addiction_Homo sapiens_hsa050323.38749909
3Circadian entrainment_Homo sapiens_hsa047133.27791283
4GABAergic synapse_Homo sapiens_hsa047273.19847197
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94888245
6Glutamatergic synapse_Homo sapiens_hsa047242.75187572
7Dopaminergic synapse_Homo sapiens_hsa047282.75152221
8Cholinergic synapse_Homo sapiens_hsa047252.61357318
9Serotonergic synapse_Homo sapiens_hsa047262.37993657
10Insulin secretion_Homo sapiens_hsa049112.37278110
11Synaptic vesicle cycle_Homo sapiens_hsa047212.23161159
12Nicotine addiction_Homo sapiens_hsa050332.06149994
13Phototransduction_Homo sapiens_hsa047441.95900433
14Taste transduction_Homo sapiens_hsa047421.88201031
15Amphetamine addiction_Homo sapiens_hsa050311.77588226
16Collecting duct acid secretion_Homo sapiens_hsa049661.65915418
17B cell receptor signaling pathway_Homo sapiens_hsa046621.64232164
18Long-term potentiation_Homo sapiens_hsa047201.63240715
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61383025
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59967233
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54508415
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54005675
23Cocaine addiction_Homo sapiens_hsa050301.52004454
24Caffeine metabolism_Homo sapiens_hsa002321.50471445
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.44279582
26Alcoholism_Homo sapiens_hsa050341.42663042
27Endometrial cancer_Homo sapiens_hsa052131.38409620
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38399854
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35359958
30GnRH signaling pathway_Homo sapiens_hsa049121.34574561
31Acute myeloid leukemia_Homo sapiens_hsa052211.31188611
32Salivary secretion_Homo sapiens_hsa049701.29574471
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28288529
34Oxytocin signaling pathway_Homo sapiens_hsa049211.26990711
35Gastric acid secretion_Homo sapiens_hsa049711.24650254
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23039985
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20444175
38Renin secretion_Homo sapiens_hsa049241.20428784
39Asthma_Homo sapiens_hsa053101.20220639
40Osteoclast differentiation_Homo sapiens_hsa043801.17633624
41Gap junction_Homo sapiens_hsa045401.17626964
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.16688307
43Leishmaniasis_Homo sapiens_hsa051401.14456679
44Ras signaling pathway_Homo sapiens_hsa040141.13296184
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13100561
46Chemokine signaling pathway_Homo sapiens_hsa040621.08632098
47Colorectal cancer_Homo sapiens_hsa052101.07013840
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.05505264
49Calcium signaling pathway_Homo sapiens_hsa040201.04052532
50T cell receptor signaling pathway_Homo sapiens_hsa046601.03905600
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02454452
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.02262391
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01389274
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99525285
55cAMP signaling pathway_Homo sapiens_hsa040240.98573235
56ErbB signaling pathway_Homo sapiens_hsa040120.96323219
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.94966946
58Axon guidance_Homo sapiens_hsa043600.88718214
59Pancreatic cancer_Homo sapiens_hsa052120.88265738
60Long-term depression_Homo sapiens_hsa047300.87738855
61mTOR signaling pathway_Homo sapiens_hsa041500.86484531
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85935639
63Tight junction_Homo sapiens_hsa045300.85074544
64Notch signaling pathway_Homo sapiens_hsa043300.85041027
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83140114
66Inositol phosphate metabolism_Homo sapiens_hsa005620.80374902
67Hepatitis C_Homo sapiens_hsa051600.79237986
68Chronic myeloid leukemia_Homo sapiens_hsa052200.78746974
69VEGF signaling pathway_Homo sapiens_hsa043700.78482942
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78108620
71Estrogen signaling pathway_Homo sapiens_hsa049150.78100630
72TNF signaling pathway_Homo sapiens_hsa046680.75865566
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.75775283
74Endocytosis_Homo sapiens_hsa041440.75513513
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74926036
76Prolactin signaling pathway_Homo sapiens_hsa049170.74060666
77Shigellosis_Homo sapiens_hsa051310.74007970
78Hepatitis B_Homo sapiens_hsa051610.72221893
79Non-small cell lung cancer_Homo sapiens_hsa052230.70875486
80Type II diabetes mellitus_Homo sapiens_hsa049300.70799270
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69569568
82Melanogenesis_Homo sapiens_hsa049160.67503044
83Glioma_Homo sapiens_hsa052140.67389940
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67079149
85Measles_Homo sapiens_hsa051620.65090575
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63251510
87HIF-1 signaling pathway_Homo sapiens_hsa040660.62574850
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62413029
89Insulin signaling pathway_Homo sapiens_hsa049100.61634127
90Salmonella infection_Homo sapiens_hsa051320.60517002
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57615811
92Rap1 signaling pathway_Homo sapiens_hsa040150.56786590
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56273255
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55887674
95Allograft rejection_Homo sapiens_hsa053300.55436763
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53771736
97Influenza A_Homo sapiens_hsa051640.53600052
98Prion diseases_Homo sapiens_hsa050200.51821980
99Pyruvate metabolism_Homo sapiens_hsa006200.51728911
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51144964
101Dilated cardiomyopathy_Homo sapiens_hsa054140.50842894
102Nitrogen metabolism_Homo sapiens_hsa009100.49581869
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.47963575
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.46900182
105Thyroid hormone synthesis_Homo sapiens_hsa049180.46720356
106Lysine degradation_Homo sapiens_hsa003100.46477563
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45779113
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45717439
109Primary immunodeficiency_Homo sapiens_hsa053400.45378155
110Oocyte meiosis_Homo sapiens_hsa041140.44538142
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.43215693
112beta-Alanine metabolism_Homo sapiens_hsa004100.40109693
113Renal cell carcinoma_Homo sapiens_hsa052110.37025102
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36760483
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36584568
116MAPK signaling pathway_Homo sapiens_hsa040100.36295463
117Glucagon signaling pathway_Homo sapiens_hsa049220.36255025
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35788872
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35162564
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34641287
121Wnt signaling pathway_Homo sapiens_hsa043100.34155336
122Pathways in cancer_Homo sapiens_hsa052000.32750086
123African trypanosomiasis_Homo sapiens_hsa051430.30530403
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29662385
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.27625002
126Cardiac muscle contraction_Homo sapiens_hsa042600.26378532
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25490592
128Choline metabolism in cancer_Homo sapiens_hsa052310.24526449
129Pancreatic secretion_Homo sapiens_hsa049720.24317305
130Vibrio cholerae infection_Homo sapiens_hsa051100.23845125
131Dorso-ventral axis formation_Homo sapiens_hsa043200.22694808
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21574132
133Tuberculosis_Homo sapiens_hsa051520.21545708
134Toxoplasmosis_Homo sapiens_hsa051450.20476133
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20428234
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19314142
137Ovarian steroidogenesis_Homo sapiens_hsa049130.18632565
138Bile secretion_Homo sapiens_hsa049760.18191246

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