KCNH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1relaxation of smooth muscle (GO:0044557)7.74679701
2response to pheromone (GO:0019236)7.57091692
3retinal rod cell development (GO:0046548)7.53259522
4sodium ion export (GO:0071436)7.21870258
5G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.31538852
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.70302664
7synaptic vesicle exocytosis (GO:0016079)5.60097669
8potassium ion homeostasis (GO:0055075)5.50402078
9innervation (GO:0060384)5.47090001
10behavioral response to nicotine (GO:0035095)5.38665907
11cellular potassium ion homeostasis (GO:0030007)5.21607190
12synaptic vesicle endocytosis (GO:0048488)5.21475868
13positive regulation of synapse maturation (GO:0090129)5.19578025
14striatum development (GO:0021756)4.99643187
15cell communication by electrical coupling (GO:0010644)4.85339140
16cellular sodium ion homeostasis (GO:0006883)4.70762214
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65175154
18mating behavior (GO:0007617)4.63003688
19calcium ion import (GO:0070509)4.55799930
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.54795362
21nitric oxide mediated signal transduction (GO:0007263)4.49282413
22retinal cone cell development (GO:0046549)4.16051334
23piRNA metabolic process (GO:0034587)4.11707904
24fucose catabolic process (GO:0019317)4.06876987
25L-fucose metabolic process (GO:0042354)4.06876987
26L-fucose catabolic process (GO:0042355)4.06876987
27membrane depolarization during action potential (GO:0086010)4.02963216
28prepulse inhibition (GO:0060134)3.99599119
29cellular ketone body metabolic process (GO:0046950)3.97857527
30regulation of synapse maturation (GO:0090128)3.97501289
31potassium ion export (GO:0071435)3.95191593
32synaptic vesicle transport (GO:0048489)3.94751527
33establishment of synaptic vesicle localization (GO:0097480)3.94751527
34regulation of synaptic vesicle exocytosis (GO:2000300)3.91609616
35regulation of synapse structural plasticity (GO:0051823)3.87502288
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86114400
37response to host (GO:0075136)3.86114400
38response to host defenses (GO:0052200)3.86114400
39eye photoreceptor cell development (GO:0042462)3.76863359
40protein localization to synapse (GO:0035418)3.76429162
41synaptic vesicle maturation (GO:0016188)3.73175948
42neuroblast proliferation (GO:0007405)3.69049448
43photoreceptor cell development (GO:0042461)3.68582063
44positive regulation of gastrulation (GO:2000543)3.67135496
45retinal ganglion cell axon guidance (GO:0031290)3.66032703
46regulation of cardioblast proliferation (GO:0003264)3.63327246
47regulation of secondary heart field cardioblast proliferation (GO:0003266)3.63327246
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.62891697
49substrate-independent telencephalic tangential migration (GO:0021826)3.62891697
50water-soluble vitamin biosynthetic process (GO:0042364)3.62747026
51peristalsis (GO:0030432)3.61349424
52ketone body metabolic process (GO:1902224)3.59610053
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.53573136
54positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.51964190
55glycerophospholipid catabolic process (GO:0046475)3.51474070
56nephron epithelium morphogenesis (GO:0072088)3.50966375
57nephron tubule morphogenesis (GO:0072078)3.50966375
58regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.50665875
59regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.50665875
60response to host immune response (GO:0052572)3.49350073
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49350073
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46563317
63axon cargo transport (GO:0008088)3.45138108
64kidney morphogenesis (GO:0060993)3.41473461
65urinary tract smooth muscle contraction (GO:0014848)3.40824543
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39579741
67synapse assembly (GO:0007416)3.38268883
68atrial cardiac muscle cell action potential (GO:0086014)3.32118329
69regulation of action potential (GO:0098900)3.27965340
70anterograde axon cargo transport (GO:0008089)3.26528671
71positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.26287204
72positive regulation of calcium ion import (GO:0090280)3.26256628
73respiratory chain complex IV assembly (GO:0008535)3.25685010
74regulation of hexokinase activity (GO:1903299)3.24103216
75regulation of glucokinase activity (GO:0033131)3.24103216
76glycolytic process (GO:0006096)3.20457639
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.19217017
78cell communication involved in cardiac conduction (GO:0086065)3.18684100
79sialylation (GO:0097503)3.17347870
80phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.16044538
81sodium ion homeostasis (GO:0055078)3.14052265
82regulation of transforming growth factor beta2 production (GO:0032909)3.13641053
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11486381
84photoreceptor cell maintenance (GO:0045494)3.10889330
85protein polyglutamylation (GO:0018095)3.10424516
86DNA methylation involved in gamete generation (GO:0043046)3.08757249
87membrane hyperpolarization (GO:0060081)3.08215264
88axoneme assembly (GO:0035082)3.08045551
89dopamine transport (GO:0015872)3.07840494
90regulation of synaptic vesicle transport (GO:1902803)3.05064942
91relaxation of muscle (GO:0090075)3.04229586
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04199529
93cGMP biosynthetic process (GO:0006182)3.03446816
94reflex (GO:0060004)3.02694081
95regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.00497407
96endocardial cushion morphogenesis (GO:0003203)2.99548233
97negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.98715653
98alanine transport (GO:0032328)2.98628367
99regulation of bile acid biosynthetic process (GO:0070857)2.98413073
100platelet dense granule organization (GO:0060155)2.97500930
101endocrine pancreas development (GO:0031018)2.96225374
102protein complex biogenesis (GO:0070271)2.95629555
103positive regulation of TOR signaling (GO:0032008)2.95231663
104male sex determination (GO:0030238)2.93538804
105lactate metabolic process (GO:0006089)2.93320755
106pancreas development (GO:0031016)2.93173612
107positive regulation of potassium ion transmembrane transport (GO:1901381)2.92274730
108calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.92112431
109renal tubule morphogenesis (GO:0061333)2.91976778
110dentate gyrus development (GO:0021542)2.91439793
111regulation of voltage-gated calcium channel activity (GO:1901385)2.89749298
112proline transport (GO:0015824)2.87644003
113positive regulation of potassium ion transport (GO:0043268)2.87067513
114primary amino compound metabolic process (GO:1901160)2.85986013
115long-term synaptic potentiation (GO:0060291)2.85816239
116positive regulation of cGMP biosynthetic process (GO:0030828)2.85730502
117neuronal action potential (GO:0019228)2.84898187
118nonmotile primary cilium assembly (GO:0035058)2.82883603
119establishment of vesicle localization (GO:0051650)2.82818679
120long term synaptic depression (GO:0060292)2.81044219
121neurotransmitter secretion (GO:0007269)2.80543180
122sensory perception of light stimulus (GO:0050953)2.79355518
123cytochrome complex assembly (GO:0017004)2.78410041
124visual perception (GO:0007601)2.78340340
125secondary heart field specification (GO:0003139)2.76889068
126heart field specification (GO:0003128)2.76889068
127regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.76697157
128epithelial cilium movement (GO:0003351)2.75751045
129positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.75020778
130homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.74965124
131mitochondrial respiratory chain complex assembly (GO:0033108)2.74712067
132apical protein localization (GO:0045176)2.74515325
133indolalkylamine metabolic process (GO:0006586)2.73720763
134gamma-aminobutyric acid transport (GO:0015812)2.71969008
135insulin secretion (GO:0030073)2.69843244
136behavioral response to ethanol (GO:0048149)2.66213984
137serotonin metabolic process (GO:0042428)2.65090690
138auditory receptor cell differentiation (GO:0042491)2.64409264
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64349027
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.64349027
141NADH dehydrogenase complex assembly (GO:0010257)2.64349027
142indole-containing compound catabolic process (GO:0042436)2.62881752
143indolalkylamine catabolic process (GO:0046218)2.62881752
144tryptophan catabolic process (GO:0006569)2.62881752
145DNA deamination (GO:0045006)2.62829142
146regulation of neurotransmitter uptake (GO:0051580)2.61705327
147synaptic transmission, cholinergic (GO:0007271)2.60069194
148artery development (GO:0060840)2.59455800
149ubiquinone metabolic process (GO:0006743)2.59267920
150preassembly of GPI anchor in ER membrane (GO:0016254)2.55603921
151positive regulation of meiosis (GO:0045836)2.54368276
152ubiquinone biosynthetic process (GO:0006744)2.52952547
153adaptation of signaling pathway (GO:0023058)2.52592479
154negative regulation of telomere maintenance (GO:0032205)2.52208553
155somite rostral/caudal axis specification (GO:0032525)2.51167031
156adult feeding behavior (GO:0008343)2.50268558
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49717689
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.49484180
1593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.49484180
160mitotic cell cycle arrest (GO:0071850)2.47932515
161regulation of calcium ion-dependent exocytosis (GO:0017158)2.47183170
162dendritic spine morphogenesis (GO:0060997)2.45993760
163phasic smooth muscle contraction (GO:0014821)2.45866162
164auditory receptor cell stereocilium organization (GO:0060088)2.44405623
165positive regulation of action potential (GO:0045760)2.42872479
166regulation of cilium movement (GO:0003352)2.42639302
167indole-containing compound metabolic process (GO:0042430)2.41925648
168startle response (GO:0001964)2.40115163
169neuron fate specification (GO:0048665)2.39364525
170catecholamine transport (GO:0051937)2.39186379
171macroautophagy (GO:0016236)2.37898241
172cilium morphogenesis (GO:0060271)2.37827395
173cilium movement (GO:0003341)2.37521645
174positive regulation of meiotic cell cycle (GO:0051446)2.37171431
175regulation of meiosis I (GO:0060631)2.36337221
176positive regulation of insulin secretion (GO:0032024)2.36279753
177basic amino acid transport (GO:0015802)2.34346396
178nucleobase catabolic process (GO:0046113)2.34291944
179action potential (GO:0001508)2.34097538
180positive regulation of sodium ion transmembrane transport (GO:1902307)2.33942234
181spinal cord motor neuron differentiation (GO:0021522)2.33681559
182GPI anchor metabolic process (GO:0006505)2.32169474
183membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.32022925
184positive regulation of oligodendrocyte differentiation (GO:0048714)2.29537075
185detection of light stimulus involved in visual perception (GO:0050908)10.9963584
186detection of light stimulus involved in sensory perception (GO:0050962)10.9963584
187negative regulation of cytosolic calcium ion concentration (GO:0051481)10.0267525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.20446465
2ZNF274_21170338_ChIP-Seq_K562_Hela3.58252290
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17385866
4GBX2_23144817_ChIP-Seq_PC3_Human3.16530261
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.05655169
6VDR_22108803_ChIP-Seq_LS180_Human3.05208357
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.91139837
8DROSHA_22980978_ChIP-Seq_HELA_Human2.83030674
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.72580899
10EZH2_22144423_ChIP-Seq_EOC_Human2.71799376
11* EZH2_27294783_Chip-Seq_ESCs_Mouse2.67644025
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.65248737
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60279037
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.53644397
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48600748
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48195622
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47741803
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43522749
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42127594
20P53_22127205_ChIP-Seq_FIBROBLAST_Human2.29991316
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29846395
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.28961646
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.27961333
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15611454
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14971585
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.08197167
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05833186
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01259334
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95283908
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.89154238
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86325894
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84972614
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83801653
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83801653
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81105357
36IGF1R_20145208_ChIP-Seq_DFB_Human1.80882990
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.80127878
38ER_23166858_ChIP-Seq_MCF-7_Human1.78770941
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78002417
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77466145
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71976930
42* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71632050
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68078865
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.65975248
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65891363
46BCAT_22108803_ChIP-Seq_LS180_Human1.64992677
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63455493
48EWS_26573619_Chip-Seq_HEK293_Human1.59276956
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.58693797
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58156540
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.55207492
52SMAD4_21799915_ChIP-Seq_A2780_Human1.52879598
53CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.52055821
54RNF2_27304074_Chip-Seq_NSC_Mouse1.50874404
55AR_21572438_ChIP-Seq_LNCaP_Human1.49875984
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49790358
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49555928
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48955333
59TAF15_26573619_Chip-Seq_HEK293_Human1.47020275
60TP53_22573176_ChIP-Seq_HFKS_Human1.46654842
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.45793280
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44646181
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44646181
64AR_19668381_ChIP-Seq_PC3_Human1.42575913
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.40510057
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39922334
67CBP_20019798_ChIP-Seq_JUKART_Human1.38671533
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38671533
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38615569
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.38417416
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38044067
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37622629
73* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36616435
74* FOXA1_25329375_ChIP-Seq_VCAP_Human1.36616435
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36316850
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35158110
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34792812
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34383234
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32050003
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.30507386
81FUS_26573619_Chip-Seq_HEK293_Human1.29706979
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.29542341
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29455803
84TCF4_22108803_ChIP-Seq_LS180_Human1.28699427
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28647101
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28643246
87RUNX2_22187159_ChIP-Seq_PCA_Human1.28184136
88HTT_18923047_ChIP-ChIP_STHdh_Human1.27500920
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27474751
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27187556
91NANOG_19829295_ChIP-Seq_ESCs_Human1.24735768
92SOX2_19829295_ChIP-Seq_ESCs_Human1.24735768
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.24221792
94* AR_20517297_ChIP-Seq_VCAP_Human1.23826577
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23445228
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23379643
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22476719
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.22294362
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21766360
100AR_25329375_ChIP-Seq_VCAP_Human1.21231213
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17950670
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17757201
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.17266560
104* GATA3_21878914_ChIP-Seq_MCF-7_Human1.16731403
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.15209137
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.15087865
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.14834778
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14336870
109* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12792456
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.12334607
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12172873
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11945846
113NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.11664468
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11608694
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10407025
116ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09977162
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08619593
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.08242277
119IRF1_19129219_ChIP-ChIP_H3396_Human1.07642000
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06879910
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06719098
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06262334
123HOXB7_26014856_ChIP-Seq_BT474_Human1.06184806
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.06151190
125NCOR_22424771_ChIP-Seq_293T_Human1.05819169
126CDX2_22108803_ChIP-Seq_LS180_Human1.05593563
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05493729
128TCF4_23295773_ChIP-Seq_U87_Human1.04931466
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04483945
130STAT3_23295773_ChIP-Seq_U87_Human1.03620254
131* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03057769
132P53_22387025_ChIP-Seq_ESCs_Mouse1.02806370
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02608889
134P300_19829295_ChIP-Seq_ESCs_Human1.01866330
135CTCF_27219007_Chip-Seq_Bcells_Human1.00549308
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00374296
137POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99503995
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99018068
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.98170232
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97850533
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.97358861
142MYC_19829295_ChIP-Seq_ESCs_Human0.97010451
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96030547
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.96007327
145MYC_18940864_ChIP-ChIP_HL60_Human0.95714001
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95231947
147* FOXA1_25552417_ChIP-Seq_VCAP_Human0.94860072
148CBP_21632823_ChIP-Seq_H3396_Human0.92348906
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91304998
150CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90355764
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89027338
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88851863
153TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87859004
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85297330
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84954347
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.82259536
157SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.82210307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog6.12630700
2MP0006072_abnormal_retinal_apoptosis5.05643288
3MP0002090_abnormal_vision5.00052922
4MP0004782_abnormal_surfactant_physiolog4.44467593
5MP0001346_abnormal_lacrimal_gland3.76781938
6MP0001984_abnormal_olfaction3.55150330
7MP0005248_abnormal_Harderian_gland3.32639637
8MP0001502_abnormal_circadian_rhythm3.28065960
9MP0004233_abnormal_muscle_weight3.19886104
10MP0005253_abnormal_eye_physiology3.09486403
11MP0002837_dystrophic_cardiac_calcinosis2.87867288
12MP0003283_abnormal_digestive_organ2.62877339
13MP0003195_calcinosis2.51403377
14MP0006292_abnormal_olfactory_placode2.46249453
15MP0008877_abnormal_DNA_methylation2.45975047
16MP0005195_abnormal_posterior_eye2.38156623
17MP0002876_abnormal_thyroid_physiology2.26985478
18MP0008775_abnormal_heart_ventricle2.18553285
19MP0005379_endocrine/exocrine_gland_phen2.15038561
20MP0004215_abnormal_myocardial_fiber2.11895590
21MP0002163_abnormal_gland_morphology2.10994410
22MP0010386_abnormal_urinary_bladder2.10947729
23MP0004084_abnormal_cardiac_muscle2.10935320
24MP0003787_abnormal_imprinting2.07520787
25MP0005670_abnormal_white_adipose1.97457399
26MP0001485_abnormal_pinna_reflex1.94935741
27MP0000631_abnormal_neuroendocrine_gland1.91571371
28MP0000013_abnormal_adipose_tissue1.87494133
29MP0002909_abnormal_adrenal_gland1.84392113
30MP0001486_abnormal_startle_reflex1.74590159
31MP0002184_abnormal_innervation1.72460398
32MP0008789_abnormal_olfactory_epithelium1.72286947
33MP0006276_abnormal_autonomic_nervous1.71898101
34MP0004043_abnormal_pH_regulation1.71730263
35MP0004885_abnormal_endolymph1.69985712
36MP0005499_abnormal_olfactory_system1.69234372
37MP0005394_taste/olfaction_phenotype1.69234372
38MP0004133_heterotaxia1.69151639
39MP0004145_abnormal_muscle_electrophysio1.67476468
40MP0002938_white_spotting1.65070878
41MP0001324_abnormal_eye_pigmentation1.63688615
42MP0004036_abnormal_muscle_relaxation1.62064165
43MP0002234_abnormal_pharynx_morphology1.59848249
44MP0000569_abnormal_digit_pigmentation1.57874728
45MP0008872_abnormal_physiological_respon1.56187445
46MP0003136_yellow_coat_color1.55065629
47MP0002332_abnormal_exercise_endurance1.54030431
48MP0003635_abnormal_synaptic_transmissio1.51602540
49MP0002734_abnormal_mechanical_nocicepti1.49708582
50MP0002229_neurodegeneration1.48694924
51MP0002102_abnormal_ear_morphology1.48642606
52MP0002272_abnormal_nervous_system1.47788988
53MP0005595_abnormal_vascular_smooth1.47030851
54MP0005084_abnormal_gallbladder_morpholo1.46315165
55MP0002064_seizures1.46098827
56MP0005220_abnormal_exocrine_pancreas1.44544515
57MP0001188_hyperpigmentation1.40401204
58MP0005174_abnormal_tail_pigmentation1.38691970
59MP0002638_abnormal_pupillary_reflex1.36178473
60MP0002733_abnormal_thermal_nociception1.36126516
61MP0002752_abnormal_somatic_nervous1.35563941
62MP0003646_muscle_fatigue1.35384969
63MP0000538_abnormal_urinary_bladder1.34669589
64MP0003137_abnormal_impulse_conducting1.34315408
65MP0010030_abnormal_orbit_morphology1.31558719
66MP0004019_abnormal_vitamin_homeostasis1.31392707
67MP0002067_abnormal_sensory_capabilities1.31263505
68MP0010329_abnormal_lipoprotein_level1.29783410
69MP0005332_abnormal_amino_acid1.26694457
70MP0005167_abnormal_blood-brain_barrier1.25952620
71MP0003950_abnormal_plasma_membrane1.25088321
72MP0008875_abnormal_xenobiotic_pharmacok1.24655487
73MP0009046_muscle_twitch1.24520696
74MP0003122_maternal_imprinting1.24121955
75MP0002277_abnormal_respiratory_mucosa1.22622743
76MP0005391_vision/eye_phenotype1.22578717
77MP0005448_abnormal_energy_balance1.19472060
78MP0002063_abnormal_learning/memory/cond1.18737993
79MP0002653_abnormal_ependyma_morphology1.17952572
80MP0000427_abnormal_hair_cycle1.17729184
81MP0003879_abnormal_hair_cell1.13707346
82MP0001756_abnormal_urination1.11797989
83MP0002882_abnormal_neuron_morphology1.11641312
84MP0003183_abnormal_peptide_metabolism1.10371168
85MP0001905_abnormal_dopamine_level1.07528591
86MP0002138_abnormal_hepatobiliary_system1.07405560
87MP0004147_increased_porphyrin_level1.07088177
88MP0004742_abnormal_vestibular_system1.06209982
89MP0009745_abnormal_behavioral_response1.06154064
90MP0000372_irregular_coat_pigmentation1.05234617
91MP0000955_abnormal_spinal_cord1.03776521
92MP0001968_abnormal_touch/_nociception1.02882557
93MP0005386_behavior/neurological_phenoty1.02731721
94MP0004924_abnormal_behavior1.02731721
95MP0002139_abnormal_hepatobiliary_system1.01723421
96MP0001764_abnormal_homeostasis1.01158802
97MP0005075_abnormal_melanosome_morpholog0.99959700
98MP0000003_abnormal_adipose_tissue0.99942757
99MP0001919_abnormal_reproductive_system0.98583148
100MP0008569_lethality_at_weaning0.96871649
101MP0003634_abnormal_glial_cell0.96140207
102MP0003878_abnormal_ear_physiology0.96105402
103MP0005377_hearing/vestibular/ear_phenot0.96105402
104MP0003172_abnormal_lysosome_physiology0.95668255
105MP0002572_abnormal_emotion/affect_behav0.95565798
106MP0002751_abnormal_autonomic_nervous0.95249373
107MP0003953_abnormal_hormone_level0.94168986
108MP0001944_abnormal_pancreas_morphology0.93823446
109MP0005636_abnormal_mineral_homeostasis0.93734090
110MP0001765_abnormal_ion_homeostasis0.93006221
111MP0005310_abnormal_salivary_gland0.92788264
112MP0005389_reproductive_system_phenotype0.92777819
113MP0004270_analgesia0.92033741
114MP0009672_abnormal_birth_weight0.91978675
115MP0002069_abnormal_eating/drinking_beha0.91672847
116MP0002160_abnormal_reproductive_system0.90372893
117MP0004859_abnormal_synaptic_plasticity0.88678509
118MP0002928_abnormal_bile_duct0.88325182
119MP0005365_abnormal_bile_salt0.87629067
120MP0005423_abnormal_somatic_nervous0.84806823
121MP0002736_abnormal_nociception_after0.83922851
122MP0001970_abnormal_pain_threshold0.80914672
123MP0003329_amyloid_beta_deposits0.80844483
124MP0002557_abnormal_social/conspecific_i0.80562596
125MP0002822_catalepsy0.80146810
126MP0004085_abnormal_heartbeat0.79835608
127MP0005646_abnormal_pituitary_gland0.77818285
128MP0003959_abnormal_lean_body0.77651359
129MP0008004_abnormal_stomach_pH0.77341100
130MP0001661_extended_life_span0.75780535
131MP0003011_delayed_dark_adaptation0.75418229
132MP0001501_abnormal_sleep_pattern0.74708651
133MP0010368_abnormal_lymphatic_system0.74407078
134MP0001986_abnormal_taste_sensitivity0.74075758
135MP0004811_abnormal_neuron_physiology0.73752095
136MP0000230_abnormal_systemic_arterial0.73678146
137MP0002693_abnormal_pancreas_physiology0.71840670
138MP0005645_abnormal_hypothalamus_physiol0.71820067
139MP0003880_abnormal_central_pattern0.71634027
140MP0001529_abnormal_vocalization0.71188299
141MP0002078_abnormal_glucose_homeostasis0.70873561
142MP0004142_abnormal_muscle_tone0.70458739
143MP0003633_abnormal_nervous_system0.69903439
144MP0003890_abnormal_embryonic-extraembry0.67742962
145MP0008961_abnormal_basal_metabolism0.63442845
146MP0002152_abnormal_brain_morphology0.61399076
147MP0006035_abnormal_mitochondrial_morpho0.60783929
148MP0009780_abnormal_chondrocyte_physiolo0.60346064
149MP0002066_abnormal_motor_capabilities/c0.59661980
150MP0002697_abnormal_eye_size0.58341130
151MP0004858_abnormal_nervous_system0.57845038
152MP0002735_abnormal_chemical_nociception0.57629066
153MP0002269_muscular_atrophy0.57079929

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.72067006
2Severe visual impairment (HP:0001141)7.68958887
3Abnormality of macular pigmentation (HP:0008002)7.50456178
4Septo-optic dysplasia (HP:0100842)6.75731123
5Abnormal rod and cone electroretinograms (HP:0008323)6.08207516
6Hypoplasia of the fovea (HP:0007750)5.60659043
7Aplasia/Hypoplasia of the fovea (HP:0008060)5.60659043
8Scotoma (HP:0000575)5.50553031
9Albinism (HP:0001022)5.30034930
10Abnormality of the fovea (HP:0000493)4.62741905
11Decreased central vision (HP:0007663)4.29168383
12Pancreatic cysts (HP:0001737)4.04210956
13Pancreatic fibrosis (HP:0100732)3.89839318
14Molar tooth sign on MRI (HP:0002419)3.78538415
15Abnormality of midbrain morphology (HP:0002418)3.78538415
16Abnormal gallbladder physiology (HP:0012438)3.70316512
17Cholecystitis (HP:0001082)3.70316512
18Aplasia/Hypoplasia of the macula (HP:0008059)3.66744278
19Aplasia/Hypoplasia affecting the retina (HP:0008061)3.53015143
20Optic nerve hypoplasia (HP:0000609)3.47391285
21True hermaphroditism (HP:0010459)3.43677742
22Bony spicule pigmentary retinopathy (HP:0007737)3.42717995
23Epileptic encephalopathy (HP:0200134)3.42707988
24Absent septum pellucidum (HP:0001331)3.38271783
25Hemiparesis (HP:0001269)3.38126672
26Nephronophthisis (HP:0000090)3.34512918
27Hypothermia (HP:0002045)3.30206859
28Febrile seizures (HP:0002373)3.25332012
29Abnormality of the renal cortex (HP:0011035)3.22949386
30Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.20044835
31Severe Myopia (HP:0011003)3.10235186
32Type II lissencephaly (HP:0007260)3.07842323
33Neoplasm of the heart (HP:0100544)3.02126150
34Hyperventilation (HP:0002883)2.99342452
35Abnormality of the renal medulla (HP:0100957)2.95429402
36Visual hallucinations (HP:0002367)2.87190666
37Abnormal pupillary function (HP:0007686)2.85073637
38Generalized hypopigmentation (HP:0007513)2.82913160
39Gaze-evoked nystagmus (HP:0000640)2.81188798
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.75301635
41Abnormality of the septum pellucidum (HP:0007375)2.74070219
42Abnormality of the sella turcica (HP:0002679)2.72834513
43Prolonged QT interval (HP:0001657)2.65745562
44Cystic liver disease (HP:0006706)2.60656579
45Ketoacidosis (HP:0001993)2.60372770
46Tubular atrophy (HP:0000092)2.57860934
47Absence seizures (HP:0002121)2.56476086
48Increased corneal curvature (HP:0100692)2.55956420
49Keratoconus (HP:0000563)2.55956420
50Polydipsia (HP:0001959)2.51483126
51Abnormal drinking behavior (HP:0030082)2.51483126
52Abolished electroretinogram (ERG) (HP:0000550)2.47705963
53Intestinal atresia (HP:0011100)2.45089438
54Abnormality of vitamin B metabolism (HP:0004340)2.44282797
55Primary adrenal insufficiency (HP:0008207)2.43584332
56Agitation (HP:0000713)2.43153009
57Chronic hepatic failure (HP:0100626)2.42516488
58Large for gestational age (HP:0001520)2.41093021
59Fatigue (HP:0012378)2.40132129
60Ketosis (HP:0001946)2.38420462
61Sclerocornea (HP:0000647)2.37473345
62Renal cortical cysts (HP:0000803)2.36516306
63Attenuation of retinal blood vessels (HP:0007843)2.34455336
64Growth hormone deficiency (HP:0000824)2.31949213
65Aplasia/hypoplasia of the uterus (HP:0008684)2.26032629
66Inability to walk (HP:0002540)2.25899967
67Hypoglycemic seizures (HP:0002173)2.25472722
68Methylmalonic acidemia (HP:0002912)2.24958933
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24128505
70Hypomagnesemia (HP:0002917)2.19772425
71Lissencephaly (HP:0001339)2.19743674
72Furrowed tongue (HP:0000221)2.19553028
73Progressive cerebellar ataxia (HP:0002073)2.17781670
74Congenital sensorineural hearing impairment (HP:0008527)2.17759428
75Dialeptic seizures (HP:0011146)2.14803387
76Pancreatic islet-cell hyperplasia (HP:0004510)2.13253332
77Cerebellar dysplasia (HP:0007033)2.13041599
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12925811
79Abnormality of alanine metabolism (HP:0010916)2.12925811
80Hyperalaninemia (HP:0003348)2.12925811
81Gait imbalance (HP:0002141)2.12268067
82Male pseudohermaphroditism (HP:0000037)2.12028934
83Bile duct proliferation (HP:0001408)2.10561932
84Abnormal biliary tract physiology (HP:0012439)2.10561932
85Abnormality of the pancreatic islet cells (HP:0006476)2.08663473
86Abnormality of endocrine pancreas physiology (HP:0012093)2.08663473
87Genetic anticipation (HP:0003743)2.07768761
88Mutism (HP:0002300)2.07545219
89Broad-based gait (HP:0002136)2.07436102
90Tachypnea (HP:0002789)2.06262581
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06055711
92Congenital primary aphakia (HP:0007707)2.04067128
93Hypoglycemic coma (HP:0001325)2.03468212
94Polyuria (HP:0000103)2.02632741
95Methylmalonic aciduria (HP:0012120)2.00763483
96Aplasia/Hypoplasia of the tibia (HP:0005772)2.00330849
97Depression (HP:0000716)2.00191834
98Congenital stationary night blindness (HP:0007642)15.6725577
99EEG with generalized epileptiform discharges (HP:0011198)1.99320887
100Unsteady gait (HP:0002317)1.98430612
101Mitochondrial inheritance (HP:0001427)1.98363288
102Congenital, generalized hypertrichosis (HP:0004540)1.97163941
103Abnormality of the pons (HP:0007361)1.96027136
104Progressive inability to walk (HP:0002505)1.93835904
105Type II diabetes mellitus (HP:0005978)1.93303314
106Abnormality of urine glucose concentration (HP:0011016)1.92412990
107Glycosuria (HP:0003076)1.92412990
108Hyperinsulinemic hypoglycemia (HP:0000825)1.91188475
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.91127333
110Hyperglycinuria (HP:0003108)1.90637153
111Epileptiform EEG discharges (HP:0011182)1.89949972
112Photophobia (HP:0000613)1.89696891
113Acute necrotizing encephalopathy (HP:0006965)1.89183811
114Limb dystonia (HP:0002451)1.87992161
115Medial flaring of the eyebrow (HP:0010747)1.87414930
116Hypoplasia of the pons (HP:0012110)1.86892911
117Progressive macrocephaly (HP:0004481)1.86809519
118Oligodactyly (hands) (HP:0001180)1.86485063
119Pachygyria (HP:0001302)1.86194840
120Ventricular fibrillation (HP:0001663)1.85905890
121Acute encephalopathy (HP:0006846)1.84907216
122Decreased circulating renin level (HP:0003351)1.84354908
123Increased CSF lactate (HP:0002490)1.84274356
124Hepatic necrosis (HP:0002605)1.84263257
125Nephrogenic diabetes insipidus (HP:0009806)1.83539657
126Anencephaly (HP:0002323)1.83049847
127Hypoplasia of the uterus (HP:0000013)1.82560646
128Chorioretinal coloboma (HP:0000567)1.82529661
129Disproportionate short-trunk short stature (HP:0003521)1.81924629
130Congenital hepatic fibrosis (HP:0002612)1.81025370
131Absent/shortened dynein arms (HP:0200106)1.79475085
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.79475085
133Pigmentary retinal degeneration (HP:0001146)1.78947091
1343-Methylglutaconic aciduria (HP:0003535)1.77905731
135Abnormal albumin level (HP:0012116)1.77462254
136Hypoalbuminemia (HP:0003073)1.77462254
137Microretrognathia (HP:0000308)1.77327257
138Neoplasm of the adrenal cortex (HP:0100641)1.77174760
139Abnormal pancreas size (HP:0012094)1.76725752
140Poor coordination (HP:0002370)1.75784776
141Increased neuronal autofluorescent lipopigment (HP:0002074)1.75752772
142Ependymoma (HP:0002888)1.74294326
143Ankle clonus (HP:0011448)1.72011266
144Myoglobinuria (HP:0002913)1.70290118
145Pendular nystagmus (HP:0012043)1.69478619
146Action tremor (HP:0002345)1.68421464
147Flat cornea (HP:0007720)1.68144655
148Symptomatic seizures (HP:0011145)1.67521422
149Long toe (HP:0010511)1.65556689
150Hand muscle atrophy (HP:0009130)1.65254493
151Hypsarrhythmia (HP:0002521)1.61206198
152Dysdiadochokinesis (HP:0002075)1.60671222
153Abdominal situs inversus (HP:0003363)1.59852958
154Abnormality of abdominal situs (HP:0011620)1.59852958
155Increased cerebral lipofuscin (HP:0011813)1.59783708
156Pheochromocytoma (HP:0002666)1.57252782
157Retinal dysplasia (HP:0007973)1.57131863
158Abnormal EKG (HP:0003115)1.54811398
159Left ventricular hypertrophy (HP:0001712)1.52633198
160Abnormality of calcium-phosphate metabolism (HP:0100530)1.52628662
161Volvulus (HP:0002580)1.52273249
162Supranuclear gaze palsy (HP:0000605)1.51002686
163Palpitations (HP:0001962)1.50319857
164Abnormal gallbladder morphology (HP:0012437)1.48221319
165Absent rod-and cone-mediated responses on ERG (HP:0007688)1.46918932
166Myokymia (HP:0002411)1.46399114
167Hyperkalemia (HP:0002153)1.46280404
168Insulin-resistant diabetes mellitus (HP:0000831)1.46111717
169Cholelithiasis (HP:0001081)1.43466819
170Retinitis pigmentosa (HP:0000510)1.43358561
171Arterial tortuosity (HP:0005116)1.42749161
172Excessive salivation (HP:0003781)1.40881727
173Drooling (HP:0002307)1.40881727
174Aplasia/Hypoplasia of the lens (HP:0008063)1.39582195
175Genital tract atresia (HP:0001827)1.39075459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.67303880
2EPHA35.31151532
3INSRR4.88002161
4PAK63.98069838
5ADRBK23.03245905
6PRPF4B2.99788903
7ACVR1B2.93000717
8MAP3K92.70911497
9BMPR1B2.61238304
10CDK82.44060183
11NEK12.42306742
12PHKG22.33944184
13PHKG12.33944184
14MAP4K22.27755484
15WNK32.27070019
16DYRK1A2.24451626
17MAPK152.23006542
18MAP3K42.20919107
19CAMK1D2.20649300
20TAOK22.18151776
21CAMK1G1.98579965
22DAPK21.98141305
23MAP3K71.92249451
24ZAK1.76645527
25PNCK1.75456731
26TAOK31.71676475
27TLK11.67804219
28RIPK11.64354857
29MINK11.63272036
30TAOK11.57812054
31NME11.56741109
32FGFR21.51625949
33TNK21.50530284
34FER1.48648419
35MAPK131.47978481
36STK391.38821994
37OXSR11.35441376
38MST41.33723586
39CLK11.27648761
40MAPKAPK31.26235678
41NUAK11.23574551
42TXK1.22852552
43MARK11.20613969
44MAP2K61.20223551
45MAP3K131.18443883
46HIPK21.17216571
47NTRK31.11556946
48BCKDK1.10181750
49PRKCI1.10024549
50CDK91.10014507
51CAMK2D1.08411656
52MKNK21.06822420
53TNIK1.06688606
54NTRK11.04874171
55ARAF1.03221852
56CSNK1G21.00208730
57CDC42BPA0.99968216
58STK160.98363619
59CSNK1G10.97316544
60CDK140.92719808
61STK30.92626217
62SGK4940.92014742
63SGK2230.92014742
64NLK0.91656389
65CDK30.90418489
66CDK50.90056398
67CSNK1G30.89686486
68PAK30.87009140
69BRSK20.86697375
70ROCK20.85607950
71CDK150.85490500
72KSR20.85477581
73STK380.83418720
74PRKAA10.81992683
75TGFBR10.81803553
76PTK2B0.81160693
77RPS6KA50.80835730
78MAP3K10.80529845
79CDK180.80370196
80ADRBK10.80161974
81CDK11A0.77864607
82CAMKK20.77316415
83STK110.77200192
84PRKG20.76944282
85DYRK20.76619444
86PRKCE0.72934447
87MAP2K70.72626631
88PIK3CG0.72340300
89PRKCG0.72207853
90PASK0.71326637
91STK38L0.69079958
92BRAF0.67902274
93CAMK10.66560771
94SIK20.65700038
95MAPK100.65279902
96GRK50.63805634
97UHMK10.62039654
98TIE10.62025543
99PTK20.61818227
100CASK0.61490884
101BRD40.60899582
102FES0.59148151
103PRKG10.58353751
104PLK30.55919639
105RPS6KA30.55742390
106AKT30.55584254
107CSNK1A10.55468422
108PRKCA0.55127974
109PRKCZ0.55103516
110PINK10.54994159
111PRKACB0.54665439
112VRK10.54076030
113CCNB10.53786965
114DYRK1B0.53780691
115ERBB30.51053327
116PRKAA20.50936691
117FGFR40.50894941
118PRKACA0.50703939
119GSK3B0.50449195
120IRAK10.50275998
121NEK60.49601090
122CAMK2A0.47824364
123CAMKK10.47750924
124MARK20.47288839
125CHUK0.46985573
126ICK0.46603187
127EPHA40.46583835
128SIK10.45888088
129ROCK10.44643898
130TRPM70.43301685
131BMX0.43038039
132TSSK60.42090587
133TRIM280.42065362
134RPS6KA20.41808638
135PRKD20.41111611
136GRK10.40905280
137MUSK0.40594527
138MAPK140.40477668
139BCR0.39684199
140EPHB10.39605351
141AKT10.39130216
142PRKACG0.39067464
143PRKCB0.38460644
144KSR10.38001143
145PKN10.37965233
146TEC0.37905061
147FYN0.37878518
148NTRK20.36787983
149MAPK80.36361139
150FLT30.36239482
151MAPK90.36204281
152PRKD30.35370547
153WNK40.35175284
154PLK20.34185682
155CSNK1A1L0.33954403
156ITK0.33796959
157PRKCQ0.31736517
158PIK3CA0.28665304
159CSNK1E0.28540476
160CSNK1D0.28035614

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.95984833
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69485257
3GABAergic synapse_Homo sapiens_hsa047273.64047252
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.53255682
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94732179
6Morphine addiction_Homo sapiens_hsa050322.91207768
7Insulin secretion_Homo sapiens_hsa049112.85757589
8Fructose and mannose metabolism_Homo sapiens_hsa000512.43660459
9Butanoate metabolism_Homo sapiens_hsa006502.40556304
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.38984578
11Circadian entrainment_Homo sapiens_hsa047132.37226881
12Circadian rhythm_Homo sapiens_hsa047102.36688088
13Linoleic acid metabolism_Homo sapiens_hsa005912.33176270
14Fatty acid biosynthesis_Homo sapiens_hsa000612.23771632
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12892266
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12070927
17Selenocompound metabolism_Homo sapiens_hsa004502.02050683
18Renin secretion_Homo sapiens_hsa049241.98316939
19Phototransduction_Homo sapiens_hsa047441.97199712
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.97072174
21Nitrogen metabolism_Homo sapiens_hsa009101.94741197
22Oxidative phosphorylation_Homo sapiens_hsa001901.91897192
23Sulfur metabolism_Homo sapiens_hsa009201.89346599
24Cardiac muscle contraction_Homo sapiens_hsa042601.75650050
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71243317
26Cholinergic synapse_Homo sapiens_hsa047251.67373173
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66409967
28Olfactory transduction_Homo sapiens_hsa047401.61185881
29Serotonergic synapse_Homo sapiens_hsa047261.61084463
30Ether lipid metabolism_Homo sapiens_hsa005651.60127467
31Galactose metabolism_Homo sapiens_hsa000521.55844279
32Salivary secretion_Homo sapiens_hsa049701.55674106
33Pentose phosphate pathway_Homo sapiens_hsa000301.55254883
34Oxytocin signaling pathway_Homo sapiens_hsa049211.54128983
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53762779
36Type II diabetes mellitus_Homo sapiens_hsa049301.53430491
37Tryptophan metabolism_Homo sapiens_hsa003801.48576215
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46750679
39Propanoate metabolism_Homo sapiens_hsa006401.46386091
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45512541
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44587272
42Biosynthesis of amino acids_Homo sapiens_hsa012301.41057971
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40261640
44Collecting duct acid secretion_Homo sapiens_hsa049661.39206650
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.34984015
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34749819
47Mineral absorption_Homo sapiens_hsa049781.34735867
48Peroxisome_Homo sapiens_hsa041461.31991520
49Dilated cardiomyopathy_Homo sapiens_hsa054141.29878682
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28581764
51Parkinsons disease_Homo sapiens_hsa050121.28024407
52Dopaminergic synapse_Homo sapiens_hsa047281.27412181
53Glutamatergic synapse_Homo sapiens_hsa047241.26994666
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26278704
55Caffeine metabolism_Homo sapiens_hsa002321.23067788
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22820052
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20788443
58Calcium signaling pathway_Homo sapiens_hsa040201.09490496
59Steroid biosynthesis_Homo sapiens_hsa001001.07692116
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03355143
61Basal transcription factors_Homo sapiens_hsa030221.03135987
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99735080
63Taste transduction_Homo sapiens_hsa047420.99694223
64Chemical carcinogenesis_Homo sapiens_hsa052040.98538804
65Vitamin digestion and absorption_Homo sapiens_hsa049770.98473491
66Vibrio cholerae infection_Homo sapiens_hsa051100.97943271
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97190740
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.96277762
69Fat digestion and absorption_Homo sapiens_hsa049750.96129880
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.95424364
71Ovarian steroidogenesis_Homo sapiens_hsa049130.94991718
72Retinol metabolism_Homo sapiens_hsa008300.94891664
73Alzheimers disease_Homo sapiens_hsa050100.94841569
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94166255
75RNA polymerase_Homo sapiens_hsa030200.92785391
76Cocaine addiction_Homo sapiens_hsa050300.92420158
77cAMP signaling pathway_Homo sapiens_hsa040240.91058475
78Gap junction_Homo sapiens_hsa045400.89763830
79Arachidonic acid metabolism_Homo sapiens_hsa005900.89052324
80Homologous recombination_Homo sapiens_hsa034400.86463717
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.85296499
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84553876
83Fatty acid metabolism_Homo sapiens_hsa012120.84508157
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83496454
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82464928
86Huntingtons disease_Homo sapiens_hsa050160.79921054
87mTOR signaling pathway_Homo sapiens_hsa041500.77838145
88Folate biosynthesis_Homo sapiens_hsa007900.77192030
89Amphetamine addiction_Homo sapiens_hsa050310.75669880
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.75333409
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74526656
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68876678
93One carbon pool by folate_Homo sapiens_hsa006700.68441187
94Carbon metabolism_Homo sapiens_hsa012000.67654772
95ABC transporters_Homo sapiens_hsa020100.67480372
96Fanconi anemia pathway_Homo sapiens_hsa034600.67397592
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67297516
98Long-term depression_Homo sapiens_hsa047300.67153890
99Renin-angiotensin system_Homo sapiens_hsa046140.66770148
100Histidine metabolism_Homo sapiens_hsa003400.66578492
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66066316
102beta-Alanine metabolism_Homo sapiens_hsa004100.65753482
103Metabolic pathways_Homo sapiens_hsa011000.65212405
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64429834
105Dorso-ventral axis formation_Homo sapiens_hsa043200.63907305
106Fatty acid degradation_Homo sapiens_hsa000710.60159408
107Pancreatic secretion_Homo sapiens_hsa049720.59447518
108Regulation of autophagy_Homo sapiens_hsa041400.59123292
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58775277
110Glucagon signaling pathway_Homo sapiens_hsa049220.58566940
111Inositol phosphate metabolism_Homo sapiens_hsa005620.58327866
112RNA degradation_Homo sapiens_hsa030180.58001587
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56243761
114Glycerolipid metabolism_Homo sapiens_hsa005610.55364944
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55247060
116Alcoholism_Homo sapiens_hsa050340.52959748
117HIF-1 signaling pathway_Homo sapiens_hsa040660.52790972
118GnRH signaling pathway_Homo sapiens_hsa049120.52014668
119Arginine and proline metabolism_Homo sapiens_hsa003300.51693034
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51548656
121Lysosome_Homo sapiens_hsa041420.51134007
122Purine metabolism_Homo sapiens_hsa002300.49612306
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49256802
124AMPK signaling pathway_Homo sapiens_hsa041520.48744607
125Protein digestion and absorption_Homo sapiens_hsa049740.46743350
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42853117
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42354210
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42148278
129Starch and sucrose metabolism_Homo sapiens_hsa005000.39711484
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39612093
131Bile secretion_Homo sapiens_hsa049760.39437469
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39383704
133N-Glycan biosynthesis_Homo sapiens_hsa005100.39056324
134Gastric acid secretion_Homo sapiens_hsa049710.36007872
135MAPK signaling pathway_Homo sapiens_hsa040100.35631559
136Renal cell carcinoma_Homo sapiens_hsa052110.34721128
137Thyroid hormone synthesis_Homo sapiens_hsa049180.30218360
138Sphingolipid metabolism_Homo sapiens_hsa006000.27943010
139Other glycan degradation_Homo sapiens_hsa005110.27389852
140Insulin signaling pathway_Homo sapiens_hsa049100.26148749
141Endometrial cancer_Homo sapiens_hsa052130.25680156
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23556545
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.23297159
144Pyruvate metabolism_Homo sapiens_hsa006200.21870140
145Type I diabetes mellitus_Homo sapiens_hsa049400.21677185
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20981611
147Choline metabolism in cancer_Homo sapiens_hsa052310.16721834
148Protein export_Homo sapiens_hsa030600.16030777
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15973167
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15886585
151Estrogen signaling pathway_Homo sapiens_hsa049150.15594140
152Phenylalanine metabolism_Homo sapiens_hsa003600.13636271

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