KCNH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.82847240
2vocalization behavior (GO:0071625)5.58106617
3synaptic vesicle exocytosis (GO:0016079)5.54539148
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46075044
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.41263014
6neuronal action potential propagation (GO:0019227)5.40596584
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.33741547
8glutamate secretion (GO:0014047)5.32432325
9neuron cell-cell adhesion (GO:0007158)5.30197683
10protein localization to synapse (GO:0035418)5.27598570
11negative regulation of translation, ncRNA-mediated (GO:0040033)5.09612824
12regulation of translation, ncRNA-mediated (GO:0045974)5.09612824
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.09612824
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.95162923
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.91232685
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.88025611
17regulation of glutamate receptor signaling pathway (GO:1900449)4.86735135
18heparin biosynthetic process (GO:0030210)4.78848409
19heparin metabolic process (GO:0030202)4.78848409
20regulation of synaptic vesicle exocytosis (GO:2000300)4.74756596
21presynaptic membrane assembly (GO:0097105)4.67118822
22glutamate receptor signaling pathway (GO:0007215)4.65788498
23nucleobase catabolic process (GO:0046113)4.58140784
24central nervous system projection neuron axonogenesis (GO:0021952)4.52170931
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.50965517
26locomotory exploration behavior (GO:0035641)4.44865257
27synaptic transmission, glutamatergic (GO:0035249)4.44174727
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.41405898
29synaptic vesicle maturation (GO:0016188)4.38822801
30neuron-neuron synaptic transmission (GO:0007270)4.35870174
31regulation of axon regeneration (GO:0048679)4.32774362
32regulation of neuron projection regeneration (GO:0070570)4.32774362
33regulation of synaptic vesicle transport (GO:1902803)4.24826285
34neuronal ion channel clustering (GO:0045161)4.21849674
35presynaptic membrane organization (GO:0097090)4.21299839
36negative regulation of synaptic transmission, GABAergic (GO:0032229)4.20865785
37central nervous system neuron axonogenesis (GO:0021955)4.07541915
38postsynaptic membrane organization (GO:0001941)4.06808644
39regulation of collateral sprouting (GO:0048670)4.04995802
40neurotransmitter-gated ion channel clustering (GO:0072578)4.04904267
41regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01306617
42neuron recognition (GO:0008038)4.00838465
43neurotransmitter secretion (GO:0007269)3.93891683
44retinal cone cell development (GO:0046549)3.90765228
45regulation of postsynaptic membrane potential (GO:0060078)3.88457392
46olfactory bulb development (GO:0021772)3.87525486
47exploration behavior (GO:0035640)3.87397120
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87143566
49cerebellar Purkinje cell differentiation (GO:0021702)3.83284824
50regulation of neuronal synaptic plasticity (GO:0048168)3.80668222
51regulation of timing of cell differentiation (GO:0048505)3.75650007
52startle response (GO:0001964)3.74817414
53response to histamine (GO:0034776)3.71974335
54long-term synaptic potentiation (GO:0060291)3.71608582
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70039417
56behavioral response to ethanol (GO:0048149)3.69641156
57regulation of development, heterochronic (GO:0040034)3.68497758
58negative regulation of astrocyte differentiation (GO:0048712)3.68219284
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68158597
60axonal fasciculation (GO:0007413)3.67275378
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.66481720
62behavioral response to nicotine (GO:0035095)3.65443785
63positive regulation of membrane potential (GO:0045838)3.65169251
64positive regulation of synapse maturation (GO:0090129)3.63011365
65regulation of synaptic plasticity (GO:0048167)3.57099103
66long-term memory (GO:0007616)3.56395808
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.55025049
68retinal ganglion cell axon guidance (GO:0031290)3.53604660
69gamma-aminobutyric acid transport (GO:0015812)3.47074107
70dendritic spine morphogenesis (GO:0060997)3.46742892
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44544772
72regulation of neurotransmitter secretion (GO:0046928)3.43705683
73membrane depolarization during action potential (GO:0086010)3.41670048
74establishment of mitochondrion localization (GO:0051654)3.40474011
75membrane depolarization (GO:0051899)3.39847294
76negative regulation of dendrite morphogenesis (GO:0050774)3.38660083
77auditory behavior (GO:0031223)3.38650501
78synaptic vesicle endocytosis (GO:0048488)3.37255747
79transmission of nerve impulse (GO:0019226)3.37250901
80proline transport (GO:0015824)3.36960819
81regulation of vesicle fusion (GO:0031338)3.34996646
82innervation (GO:0060384)3.34220028
83positive regulation of mitochondrial fission (GO:0090141)3.34169536
84positive regulation of neurotransmitter secretion (GO:0001956)3.34010478
85negative regulation of dendrite development (GO:2000171)3.32681013
86mechanosensory behavior (GO:0007638)3.30939756
87dentate gyrus development (GO:0021542)3.30364824
88regulation of dendritic spine morphogenesis (GO:0061001)3.27337940
89neurotransmitter transport (GO:0006836)3.27058448
90layer formation in cerebral cortex (GO:0021819)3.26388885
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26088430
92behavioral defense response (GO:0002209)3.21738313
93behavioral fear response (GO:0001662)3.21738313
94response to pheromone (GO:0019236)3.19216826
95positive regulation of developmental pigmentation (GO:0048087)3.18916327
96positive regulation of CREB transcription factor activity (GO:0032793)3.18170609
97fear response (GO:0042596)3.16980718
98synapse assembly (GO:0007416)3.15855070
99cellular potassium ion homeostasis (GO:0030007)3.15442562
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15338865
101cerebellar granule cell differentiation (GO:0021707)3.14704905
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13132596
103regulation of dendritic spine development (GO:0060998)3.11429242
104detection of calcium ion (GO:0005513)3.10170899
105cochlea development (GO:0090102)3.10155270
106membrane hyperpolarization (GO:0060081)3.09976759
107learning (GO:0007612)3.09746977
108negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08915315
109* synaptic transmission (GO:0007268)3.08187779
110G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08079492
111behavioral response to cocaine (GO:0048148)3.05778224
112regulation of neurotransmitter transport (GO:0051588)3.05017287
113positive regulation of synapse assembly (GO:0051965)3.04908075
114detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.04894388
115regulation of synapse maturation (GO:0090128)3.04217094
116serotonin receptor signaling pathway (GO:0007210)3.03713627
117righting reflex (GO:0060013)3.02307899
118regulation of synapse structural plasticity (GO:0051823)3.01573476
119positive regulation of neurotransmitter transport (GO:0051590)3.00583895
120serotonin metabolic process (GO:0042428)2.97265595
121cardiac chamber formation (GO:0003207)2.95656903
122regulation of synaptic transmission (GO:0050804)2.95493276
123long term synaptic depression (GO:0060292)2.94893472
124regulation of neurotransmitter levels (GO:0001505)2.92961042
125chemosensory behavior (GO:0007635)2.92090491
126regulation of voltage-gated calcium channel activity (GO:1901385)2.92005814
127positive regulation of synaptic transmission (GO:0050806)2.91716704
128C4-dicarboxylate transport (GO:0015740)2.89648680
129regulation of synapse assembly (GO:0051963)2.88562272
130regulation of respiratory system process (GO:0044065)2.87166950
131regulation of glutamate secretion (GO:0014048)2.86234549
132regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82410723
133neuromuscular process (GO:0050905)2.81444150
134calcium ion-dependent exocytosis (GO:0017156)2.81121406
135dendrite development (GO:0016358)2.77606988
136protein polyglutamylation (GO:0018095)2.77236191
137heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.76609724
138regulation of sarcomere organization (GO:0060297)2.76076322
139response to auditory stimulus (GO:0010996)2.75426958
140neurofilament cytoskeleton organization (GO:0060052)2.74886812
141ephrin receptor signaling pathway (GO:0048013)2.70288562
142axonogenesis (GO:0007409)2.70141388
143regulation of heat generation (GO:0031650)2.68951740
144cell migration in hindbrain (GO:0021535)2.68733895
145neuromuscular synaptic transmission (GO:0007274)2.68156154
146cerebral cortex radially oriented cell migration (GO:0021799)2.67718374
147dendrite morphogenesis (GO:0048813)2.66832751
148regulation of mitochondrial fission (GO:0090140)2.63940693
149detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.63788661
150hippocampus development (GO:0021766)2.63776810
151cardiac ventricle formation (GO:0003211)2.63622117
152positive regulation of actin cytoskeleton reorganization (GO:2000251)2.63386169
153positive regulation of amino acid transport (GO:0051957)2.61107238
154regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.60115757
155neural tube formation (GO:0001841)2.59632338
156mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.58913435
157positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.58913435
158synapse organization (GO:0050808)2.56790929
159positive regulation of dendritic spine morphogenesis (GO:0061003)2.56294763
160regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.55717301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14532839
2GBX2_23144817_ChIP-Seq_PC3_Human4.48362753
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10624805
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08633017
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94130428
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61321250
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53350481
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53350481
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.49071901
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48874826
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48379510
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.45934726
13* TAF15_26573619_Chip-Seq_HEK293_Human2.44925727
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38639547
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.37255605
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28988473
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24616748
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23050476
19EWS_26573619_Chip-Seq_HEK293_Human2.22767241
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20599296
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16055923
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07670134
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06436385
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.05420100
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.04218221
26DROSHA_22980978_ChIP-Seq_HELA_Human2.00078365
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99605531
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.98223082
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.96081708
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94562521
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.92889240
32P300_19829295_ChIP-Seq_ESCs_Human1.92844201
33AR_21572438_ChIP-Seq_LNCaP_Human1.90413059
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.86353174
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76545781
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70875323
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70864009
38* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70774948
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64694809
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63440633
41FUS_26573619_Chip-Seq_HEK293_Human1.63320528
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.60187548
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.59598989
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58787214
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.54106295
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54079773
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51843796
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50088161
49IGF1R_20145208_ChIP-Seq_DFB_Human1.49429294
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47423082
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45910724
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45852917
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43105543
54AR_25329375_ChIP-Seq_VCAP_Human1.42673197
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40615227
56VDR_22108803_ChIP-Seq_LS180_Human1.40546411
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39027693
58CBP_20019798_ChIP-Seq_JUKART_Human1.39027693
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38829895
60RNF2_27304074_Chip-Seq_NSC_Mouse1.38784352
61* STAT3_23295773_ChIP-Seq_U87_Human1.37617123
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34801350
63* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33260438
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29972127
65ZNF274_21170338_ChIP-Seq_K562_Hela1.28114955
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27915674
67* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27909486
68* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26959669
69* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26890519
70* TCF4_23295773_ChIP-Seq_U87_Human1.25938818
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25445159
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.25346762
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23600921
74* TAL1_26923725_Chip-Seq_HPCs_Mouse1.23164235
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.21669331
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21545117
77TP53_16413492_ChIP-PET_HCT116_Human1.20867032
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20458054
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19576663
80* SOX9_26525672_Chip-Seq_HEART_Mouse1.18158355
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.18141036
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15949450
83RUNX2_22187159_ChIP-Seq_PCA_Human1.15637274
84* E2F1_18555785_Chip-Seq_ESCs_Mouse1.14974900
85TP53_18474530_ChIP-ChIP_U2OS_Human1.14768263
86ER_23166858_ChIP-Seq_MCF-7_Human1.14595706
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14460510
88TCF4_22108803_ChIP-Seq_LS180_Human1.13731508
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13508084
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13508084
91AHR_22903824_ChIP-Seq_MCF-7_Human1.13443804
92* TP53_22573176_ChIP-Seq_HFKS_Human1.13275945
93JUN_21703547_ChIP-Seq_K562_Human1.12962210
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12633993
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.12468060
96* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11403773
97RXR_22108803_ChIP-Seq_LS180_Human1.11275106
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.10737487
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.10328281
100* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10298066
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09321487
102AR_19668381_ChIP-Seq_PC3_Human1.09227471
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08336715
104* P53_22387025_ChIP-Seq_ESCs_Mouse1.07049079
105BCAT_22108803_ChIP-Seq_LS180_Human1.06771378
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06051516
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05469411
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05349414
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.05303224
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05174973
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05118898
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05063800
113* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04854917
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03129358
115KDM2B_26808549_Chip-Seq_REH_Human1.01811826
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01062841
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00030614
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.99677017
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99487910
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98431484
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98016109
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.96039654
123* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95365863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86882779
2MP0003880_abnormal_central_pattern5.52899284
3MP0003635_abnormal_synaptic_transmissio3.99407187
4MP0004270_analgesia3.93311711
5MP0009745_abnormal_behavioral_response3.51853573
6MP0001968_abnormal_touch/_nociception3.51355844
7MP0002063_abnormal_learning/memory/cond3.24936377
8MP0002064_seizures3.19501397
9MP0009046_muscle_twitch3.19298790
10MP0002572_abnormal_emotion/affect_behav2.91712971
11MP0002735_abnormal_chemical_nociception2.81021853
12MP0002736_abnormal_nociception_after2.80725964
13MP0002734_abnormal_mechanical_nocicepti2.72320678
14MP0002272_abnormal_nervous_system2.72157248
15MP0001486_abnormal_startle_reflex2.68014540
16MP0005423_abnormal_somatic_nervous2.36943882
17MP0001501_abnormal_sleep_pattern2.35045794
18MP0001440_abnormal_grooming_behavior2.23733342
19MP0002067_abnormal_sensory_capabilities2.23126282
20MP0002733_abnormal_thermal_nociception2.09963590
21MP0006276_abnormal_autonomic_nervous2.05100061
22MP0001970_abnormal_pain_threshold2.00390544
23MP0001188_hyperpigmentation1.97708529
24MP0003879_abnormal_hair_cell1.92330047
25MP0002184_abnormal_innervation1.90575425
26MP0000778_abnormal_nervous_system1.87107636
27MP0002822_catalepsy1.82730358
28MP0001984_abnormal_olfaction1.77847669
29MP0002557_abnormal_social/conspecific_i1.75599791
30MP0005386_behavior/neurological_phenoty1.74436314
31MP0004924_abnormal_behavior1.74436314
32MP0005646_abnormal_pituitary_gland1.72743707
33MP0009780_abnormal_chondrocyte_physiolo1.61076919
34MP0008569_lethality_at_weaning1.59345326
35MP0004811_abnormal_neuron_physiology1.57405642
36MP0003787_abnormal_imprinting1.56805529
37MP0001529_abnormal_vocalization1.52054299
38MP0003136_yellow_coat_color1.51799404
39MP0004858_abnormal_nervous_system1.50811106
40MP0003329_amyloid_beta_deposits1.44797714
41MP0005253_abnormal_eye_physiology1.38961081
42MP0000955_abnormal_spinal_cord1.37529245
43MP0002882_abnormal_neuron_morphology1.37450210
44MP0010386_abnormal_urinary_bladder1.35738009
45MP0002066_abnormal_motor_capabilities/c1.35369985
46MP0003890_abnormal_embryonic-extraembry1.34508548
47MP0005187_abnormal_penis_morphology1.33211761
48MP0003121_genomic_imprinting1.31634811
49MP0008877_abnormal_DNA_methylation1.31062497
50MP0001905_abnormal_dopamine_level1.30519964
51MP0004145_abnormal_muscle_electrophysio1.28991597
52MP0004142_abnormal_muscle_tone1.25672558
53MP0003633_abnormal_nervous_system1.25238248
54MP0001502_abnormal_circadian_rhythm1.24529389
55MP0005248_abnormal_Harderian_gland1.23917774
56MP0004043_abnormal_pH_regulation1.22142981
57MP0002837_dystrophic_cardiac_calcinosis1.21700127
58MP0004742_abnormal_vestibular_system1.19705798
59MP0002876_abnormal_thyroid_physiology1.16088254
60MP0005645_abnormal_hypothalamus_physiol1.15929023
61MP0002234_abnormal_pharynx_morphology1.11213186
62MP0002909_abnormal_adrenal_gland1.09577741
63MP0001963_abnormal_hearing_physiology1.09305077
64MP0000427_abnormal_hair_cycle1.08233008
65MP0008872_abnormal_physiological_respon1.08100892
66MP0003122_maternal_imprinting1.05923065
67MP0005551_abnormal_eye_electrophysiolog1.05163946
68MP0003631_nervous_system_phenotype1.04628387
69MP0002152_abnormal_brain_morphology1.02755738
70MP0004084_abnormal_cardiac_muscle1.01162867
71MP0003221_abnormal_cardiomyocyte_apopto1.00905754
72MP0002653_abnormal_ependyma_morphology0.98774458
73MP0001485_abnormal_pinna_reflex0.98317411
74MP0002928_abnormal_bile_duct0.96881436
75MP0002229_neurodegeneration0.95482952
76MP0005409_darkened_coat_color0.95335064
77MP0008874_decreased_physiological_sensi0.90704017
78MP0001986_abnormal_taste_sensitivity0.90246805
79MP0005171_absent_coat_pigmentation0.89982662
80MP0004484_altered_response_of0.89574709
81MP0000538_abnormal_urinary_bladder0.89552228
82MP0000751_myopathy0.89150698
83MP0004215_abnormal_myocardial_fiber0.87368100
84MP0000647_abnormal_sebaceous_gland0.86504170
85MP0002095_abnormal_skin_pigmentation0.86331169
86MP0002752_abnormal_somatic_nervous0.85849833
87MP0002069_abnormal_eating/drinking_beha0.85402664
88MP0004085_abnormal_heartbeat0.85214119
89MP0005195_abnormal_posterior_eye0.84903484
90MP0000631_abnormal_neuroendocrine_gland0.84050412
91MP0003119_abnormal_digestive_system0.83379787
92MP0005499_abnormal_olfactory_system0.79209079
93MP0005394_taste/olfaction_phenotype0.79209079
94MP0003755_abnormal_palate_morphology0.75300644
95MP0000569_abnormal_digit_pigmentation0.74228528
96MP0000026_abnormal_inner_ear0.73805626
97MP0003045_fibrosis0.73489009
98MP0004885_abnormal_endolymph0.72240240
99MP0005367_renal/urinary_system_phenotyp0.72172853
100MP0000516_abnormal_urinary_system0.72172853
101MP0006292_abnormal_olfactory_placode0.72065914
102MP0005535_abnormal_body_temperature0.70440668
103MP0002638_abnormal_pupillary_reflex0.70042739
104MP0001664_abnormal_digestion0.68511856
105MP0000372_irregular_coat_pigmentation0.68162655
106MP0002102_abnormal_ear_morphology0.67831840
107MP0003937_abnormal_limbs/digits/tail_de0.67754682
108MP0002233_abnormal_nose_morphology0.67644688
109MP0004510_myositis0.66898870
110MP0002139_abnormal_hepatobiliary_system0.66331015
111MP0004133_heterotaxia0.65464011
112MP0000015_abnormal_ear_pigmentation0.65322062
113MP0003172_abnormal_lysosome_physiology0.64968237
114MP0002160_abnormal_reproductive_system0.64320255
115MP0002751_abnormal_autonomic_nervous0.63494031
116MP0001177_atelectasis0.63402492
117MP0003632_abnormal_nervous_system0.57723203
118MP0001943_abnormal_respiration0.55412396
119MP0003634_abnormal_glial_cell0.55095737
120MP0002082_postnatal_lethality0.54242020
121MP0010770_preweaning_lethality0.54242020
122MP0003137_abnormal_impulse_conducting0.54064580
123MP0010769_abnormal_survival0.52430928
124MP0000920_abnormal_myelination0.51243964
125MP0003861_abnormal_nervous_system0.51020562
126MP0010768_mortality/aging0.49941109
127MP0000604_amyloidosis0.49351306
128MP0009379_abnormal_foot_pigmentation0.46939166
129MP0005623_abnormal_meninges_morphology0.45902421
130MP0003956_abnormal_body_size0.45630026

Predicted human phenotypes

RankGene SetZ-score
1Focal seizures (HP:0007359)6.33432536
2Epileptic encephalopathy (HP:0200134)6.27183289
3Febrile seizures (HP:0002373)6.19570898
4Atonic seizures (HP:0010819)6.18241723
5Myokymia (HP:0002411)5.75827785
6Hyperventilation (HP:0002883)5.25371622
7Absence seizures (HP:0002121)5.15815408
8Dialeptic seizures (HP:0011146)4.68354941
9Progressive cerebellar ataxia (HP:0002073)4.37147322
10Generalized tonic-clonic seizures (HP:0002069)4.35406615
11Visual hallucinations (HP:0002367)4.18675957
12Broad-based gait (HP:0002136)4.11486635
13Gaze-evoked nystagmus (HP:0000640)3.70410298
14Amblyopia (HP:0000646)3.58340087
15Poor eye contact (HP:0000817)3.45964168
16Hepatoblastoma (HP:0002884)3.35629993
17Pancreatic fibrosis (HP:0100732)3.27668962
18Excessive salivation (HP:0003781)3.18667567
19Drooling (HP:0002307)3.18667567
20Inability to walk (HP:0002540)3.14072835
21Absent speech (HP:0001344)3.12811512
22Truncal ataxia (HP:0002078)3.07491510
23Neoplasm of the adrenal cortex (HP:0100641)3.05268332
24Lissencephaly (HP:0001339)2.96940075
25Epileptiform EEG discharges (HP:0011182)2.96409680
26Impaired social interactions (HP:0000735)2.96360674
27Abnormal social behavior (HP:0012433)2.96360674
28Action tremor (HP:0002345)2.94891304
29Pancreatic cysts (HP:0001737)2.94599408
30Impaired vibration sensation in the lower limbs (HP:0002166)2.92976539
31Protruding tongue (HP:0010808)2.90476390
32Type II lissencephaly (HP:0007260)2.76580605
33Nephronophthisis (HP:0000090)2.76414688
34Dysmetria (HP:0001310)2.72018835
35Peripheral hypomyelination (HP:0007182)2.65430629
36Scanning speech (HP:0002168)2.65375126
37Cerebellar dysplasia (HP:0007033)2.64935165
38Abnormality of midbrain morphology (HP:0002418)2.64812240
39Molar tooth sign on MRI (HP:0002419)2.64812240
40Thyroid-stimulating hormone excess (HP:0002925)2.63697789
41Urinary bladder sphincter dysfunction (HP:0002839)2.63350941
42Dysdiadochokinesis (HP:0002075)2.61425711
43Impaired smooth pursuit (HP:0007772)2.58990092
44True hermaphroditism (HP:0010459)2.56643975
45EEG with generalized epileptiform discharges (HP:0011198)2.55651295
46Progressive inability to walk (HP:0002505)2.55188247
47Supranuclear gaze palsy (HP:0000605)2.54265357
48Colon cancer (HP:0003003)2.54030436
49Fetal akinesia sequence (HP:0001989)2.50864402
50Fair hair (HP:0002286)2.48195826
51Abnormality of the renal medulla (HP:0100957)2.47591246
52Blue irides (HP:0000635)2.43432653
53Insidious onset (HP:0003587)2.43370230
54Termporal pattern (HP:0011008)2.43370230
55Abnormal eating behavior (HP:0100738)2.42633831
56Stereotypic behavior (HP:0000733)2.39453185
57Status epilepticus (HP:0002133)2.39448613
58Hemiparesis (HP:0001269)2.39401100
59Anxiety (HP:0000739)2.39245497
60Generalized hypopigmentation of hair (HP:0011358)2.36908393
61Epidermoid cyst (HP:0200040)2.36847231
62Vaginal atresia (HP:0000148)2.33416474
63Ankle clonus (HP:0011448)2.30357277
64Abnormality of salivation (HP:0100755)2.29167723
65Depression (HP:0000716)2.28709349
66Chronic hepatic failure (HP:0100626)2.28380467
67Abnormality of the metopic suture (HP:0005556)2.26411152
68Hypsarrhythmia (HP:0002521)2.26017326
69Exotropia (HP:0000577)2.25173531
70Gait imbalance (HP:0002141)2.23827409
71Intellectual disability, severe (HP:0010864)2.22957104
72Genetic anticipation (HP:0003743)2.22917578
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.21511272
74Generalized myoclonic seizures (HP:0002123)2.20678641
75Abnormality of binocular vision (HP:0011514)2.18928650
76Diplopia (HP:0000651)2.18928650
77Pheochromocytoma (HP:0002666)2.17115286
78Abnormality of the lower motor neuron (HP:0002366)2.15731231
79Impaired vibratory sensation (HP:0002495)2.15379245
80Urinary urgency (HP:0000012)2.14187395
81Pachygyria (HP:0001302)2.13749686
82Amyotrophic lateral sclerosis (HP:0007354)2.10623113
83Abnormality of ocular smooth pursuit (HP:0000617)2.08448526
84Tented upper lip vermilion (HP:0010804)2.07302520
85Astrocytoma (HP:0009592)2.06367105
86Abnormality of the astrocytes (HP:0100707)2.06367105
87Postaxial foot polydactyly (HP:0001830)2.06158448
88Abnormality of the pubic bones (HP:0003172)2.05031363
89Postural instability (HP:0002172)2.03107676
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02874980
91Glioma (HP:0009733)2.02553460
92Abnormality of the renal cortex (HP:0011035)2.02460354
93Stomach cancer (HP:0012126)2.00979598
94Polyphagia (HP:0002591)2.00671231
95Medial flaring of the eyebrow (HP:0010747)2.00647678
96Widely spaced teeth (HP:0000687)2.00568098
97Neuroendocrine neoplasm (HP:0100634)2.00379842
98Focal motor seizures (HP:0011153)10.0108214
99Abnormality of the vocal cords (HP:0008777)1.99556070
100Spastic gait (HP:0002064)1.98677382
101Abnormality of the corticospinal tract (HP:0002492)1.98327472
102Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96909850
103Hypoplasia of the brainstem (HP:0002365)1.96909850
104Congenital primary aphakia (HP:0007707)1.95927341
105Incomplete penetrance (HP:0003829)1.95568014
106Dysmetric saccades (HP:0000641)1.94661910
107Narrow forehead (HP:0000341)1.93184579
108Nephrogenic diabetes insipidus (HP:0009806)1.92472827
109Specific learning disability (HP:0001328)1.92383629
110Inappropriate behavior (HP:0000719)1.91037077
111Absent/shortened dynein arms (HP:0200106)1.90498000
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.90498000
113CNS hypomyelination (HP:0003429)1.89391871
114Abnormal hair whorl (HP:0010721)1.89241309
115Postaxial hand polydactyly (HP:0001162)1.89117525
116Mutism (HP:0002300)1.88788184
117Bradykinesia (HP:0002067)1.87889716
118Acanthocytosis (HP:0001927)1.87521801
119Papillary thyroid carcinoma (HP:0002895)1.86218891
120Renal cortical cysts (HP:0000803)1.85987620
121Cupped ear (HP:0000378)1.85477178
122Retinal dysplasia (HP:0007973)1.84451159
123Prominent metopic ridge (HP:0005487)1.83026319
124Medulloblastoma (HP:0002885)1.82737899
125Cystic liver disease (HP:0006706)1.81800198
126Deeply set eye (HP:0000490)1.81727998
127Poor coordination (HP:0002370)1.81427236
128Gait ataxia (HP:0002066)1.81374511
129Hyperthyroidism (HP:0000836)1.80917422
130Ulnar claw (HP:0001178)1.80762657
131Papilledema (HP:0001085)1.80536267
132Esotropia (HP:0000565)1.79391034
133Absent eyebrow (HP:0002223)1.78977151
134Hypoplasia of the corpus callosum (HP:0002079)1.78881000
135Hyperglycinemia (HP:0002154)1.77236385
136Autism (HP:0000717)1.76885685
137Bile duct proliferation (HP:0001408)1.76861684
138Abnormal biliary tract physiology (HP:0012439)1.76861684
139Clumsiness (HP:0002312)1.76695910
140Thickened helices (HP:0000391)1.76263353
141Volvulus (HP:0002580)1.74070604
142Abnormality of the labia minora (HP:0012880)1.72695491
143Lower limb muscle weakness (HP:0007340)1.71377467
144Cortical dysplasia (HP:0002539)1.70699078
145Gastroesophageal reflux (HP:0002020)1.70037922
146Focal dystonia (HP:0004373)1.68747628
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.68277592
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68277592
149Torticollis (HP:0000473)1.65773150
150Delusions (HP:0000746)1.65650939
151Cerebral inclusion bodies (HP:0100314)1.65126656
152Genital tract atresia (HP:0001827)1.64469998
153Psychosis (HP:0000709)1.62084682
154Neurofibrillary tangles (HP:0002185)1.59640069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.67297727
2NTRK34.59654865
3CASK4.32843044
4EPHA44.30002777
5MAP3K43.37435262
6MAP2K73.31870141
7MAP3K92.95651750
8RIPK42.91474068
9MAP3K122.58022431
10DAPK22.56354636
11MINK12.33540047
12MAP4K22.26077681
13MARK12.23668703
14DAPK12.15647283
15MAP2K42.10406044
16TRIM282.03143167
17CDK191.96117213
18PLK21.95472824
19TNIK1.84524740
20CCNB11.80209087
21PAK61.70665408
22PNCK1.61490054
23MAPK131.59797868
24NTRK11.56932113
25NTRK21.49888438
26BMPR21.47445156
27ERBB31.46014339
28KSR11.45247675
29CSNK1A1L1.43478569
30DYRK21.41655929
31GRK51.36261793
32EPHB11.35799297
33STK38L1.34798298
34CDK51.33825398
35LATS11.33047059
36SIK31.29774298
37SIK21.27844849
38AKT31.25144447
39CSNK1G31.24824058
40OXSR11.23366079
41KSR21.23123553
42PRPF4B1.20208842
43CAMKK21.20194322
44PRKCG1.19814659
45EPHA31.18454493
46CAMKK11.16544275
47CAMK2A1.15818398
48DYRK31.09802652
49CAMK2B1.09459753
50FGFR21.06577798
51CSNK1G11.04513892
52FES0.98116070
53PINK10.97754284
54ARAF0.97534937
55SGK20.96496480
56SGK4940.95778860
57SGK2230.95778860
58PIK3CA0.94395373
59UHMK10.90439456
60OBSCN0.87642365
61MAP3K20.85691604
62PTK2B0.84819852
63MAP3K130.83546942
64NME10.81600832
65CDK180.76853898
66ZAK0.76323445
67MAP3K50.75875808
68CAMK10.75256062
69RPS6KA40.73587178
70IRAK20.73529291
71SGK10.72485788
72PRKCE0.71479737
73IRAK10.70581417
74CDK150.69695107
75CDK140.69449230
76PRKD30.68275075
77BCR0.68045014
78BMPR1B0.67802530
79STK380.66891842
80MAP3K60.66150555
81CAMK40.63828153
82STK110.62842103
83PKN20.61941489
84RAF10.60951610
85GRK70.60505949
86CDK11A0.60023586
87NEK60.59549787
88BCKDK0.59377468
89FGR0.57554422
90LATS20.56709480
91DYRK1A0.56188457
92TNK20.54445596
93SGK30.53767090
94CAMK2D0.53589512
95RET0.53063210
96PHKG20.51918605
97PHKG10.51918605
98NUAK10.50162783
99PAK30.50031093
100MUSK0.49519968
101CSNK1G20.47919849
102WNK30.47725429
103ACVR1B0.47053114
104PDK10.47048860
105BRAF0.46808336
106FER0.45384110
107CSNK1D0.45131174
108PRKG10.44851821
109YES10.43688505
110PKN10.42513523
111INSRR0.42062422
112PDPK10.41558275
113MAP2K10.41469484
114CAMK2G0.41428761
115ADRBK20.41284259
116ADRBK10.40887898
117MAPK120.40463359
118STK390.39293104
119TAOK10.38860707
120CSNK1E0.38523941
121DYRK1B0.38475996
122DAPK30.38418841
123CAMK1G0.37643637
124FLT30.36268861
125TYRO30.36019878
126PRKCZ0.35960830
127MARK20.35846340
128RPS6KA30.35577218
129CDK30.34471498
130ROCK20.34158329
131PRKACA0.33375339
132WNK10.33182585
133CDC42BPA0.32929427
134FYN0.32408604
135LMTK20.32392597
136MAPK70.30308036
137CSNK1A10.27589867
138BRD40.24613352
139PRKCB0.22643313
140RPS6KB10.21168560
141DMPK0.20986826
142IGF1R0.20165879

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.54083705
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26176780
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.22231733
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.04601726
5Long-term potentiation_Homo sapiens_hsa047202.87863667
6Steroid biosynthesis_Homo sapiens_hsa001002.81682588
7Circadian entrainment_Homo sapiens_hsa047132.78343074
8Glutamatergic synapse_Homo sapiens_hsa047242.70848145
9Morphine addiction_Homo sapiens_hsa050322.63573189
10Amphetamine addiction_Homo sapiens_hsa050312.61852030
11GABAergic synapse_Homo sapiens_hsa047272.59993178
12Olfactory transduction_Homo sapiens_hsa047402.46208448
13Salivary secretion_Homo sapiens_hsa049702.33397198
14Butanoate metabolism_Homo sapiens_hsa006502.31090860
15Taste transduction_Homo sapiens_hsa047422.30089803
16Dopaminergic synapse_Homo sapiens_hsa047282.22706312
17Insulin secretion_Homo sapiens_hsa049112.04467458
18Collecting duct acid secretion_Homo sapiens_hsa049662.01435728
19Serotonergic synapse_Homo sapiens_hsa047262.01076244
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91414063
21Renin secretion_Homo sapiens_hsa049241.86708314
22Cholinergic synapse_Homo sapiens_hsa047251.81273372
23Calcium signaling pathway_Homo sapiens_hsa040201.76905572
24Long-term depression_Homo sapiens_hsa047301.76156047
25Gastric acid secretion_Homo sapiens_hsa049711.73626226
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69788083
27Oxytocin signaling pathway_Homo sapiens_hsa049211.69679283
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62285996
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57076748
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55437615
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46625342
32Cocaine addiction_Homo sapiens_hsa050301.39354682
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36062192
34GnRH signaling pathway_Homo sapiens_hsa049121.34398846
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29547691
36Cardiac muscle contraction_Homo sapiens_hsa042601.26943202
37cAMP signaling pathway_Homo sapiens_hsa040241.26514344
38Phototransduction_Homo sapiens_hsa047441.25849813
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22614915
40Axon guidance_Homo sapiens_hsa043601.22249974
41Gap junction_Homo sapiens_hsa045401.21756899
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12101654
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11244515
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10960600
45Vibrio cholerae infection_Homo sapiens_hsa051101.10069679
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10003593
47Oxidative phosphorylation_Homo sapiens_hsa001901.05806025
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04750720
49Type II diabetes mellitus_Homo sapiens_hsa049301.03518246
50Alzheimers disease_Homo sapiens_hsa050101.02191475
51ErbB signaling pathway_Homo sapiens_hsa040121.00392653
52Propanoate metabolism_Homo sapiens_hsa006401.00215863
53Sphingolipid metabolism_Homo sapiens_hsa006000.99855089
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99294926
55Estrogen signaling pathway_Homo sapiens_hsa049150.96814447
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.96591052
57Melanogenesis_Homo sapiens_hsa049160.94791816
58Basal transcription factors_Homo sapiens_hsa030220.93773167
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93408408
60Glioma_Homo sapiens_hsa052140.91276715
61Pancreatic secretion_Homo sapiens_hsa049720.89660669
62Fatty acid metabolism_Homo sapiens_hsa012120.88166397
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82261381
64Regulation of autophagy_Homo sapiens_hsa041400.79936604
65Oocyte meiosis_Homo sapiens_hsa041140.75780345
66Dorso-ventral axis formation_Homo sapiens_hsa043200.75755307
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74735921
68MAPK signaling pathway_Homo sapiens_hsa040100.74678877
69Tryptophan metabolism_Homo sapiens_hsa003800.71396792
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70356261
71African trypanosomiasis_Homo sapiens_hsa051430.69928523
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65588554
73Dilated cardiomyopathy_Homo sapiens_hsa054140.65363205
74Thyroid hormone synthesis_Homo sapiens_hsa049180.64144073
75Ras signaling pathway_Homo sapiens_hsa040140.63574966
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63201727
77Circadian rhythm_Homo sapiens_hsa047100.62574513
78Choline metabolism in cancer_Homo sapiens_hsa052310.62344449
79Parkinsons disease_Homo sapiens_hsa050120.61375501
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60736800
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60555393
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58906158
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58340147
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.58027843
85Glucagon signaling pathway_Homo sapiens_hsa049220.56409906
86Colorectal cancer_Homo sapiens_hsa052100.55553865
87VEGF signaling pathway_Homo sapiens_hsa043700.55165007
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53696454
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53381517
90Fatty acid elongation_Homo sapiens_hsa000620.53177268
91Rap1 signaling pathway_Homo sapiens_hsa040150.50322237
92Huntingtons disease_Homo sapiens_hsa050160.50140972
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48547655
94Rheumatoid arthritis_Homo sapiens_hsa053230.48519689
95Hedgehog signaling pathway_Homo sapiens_hsa043400.48075600
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47874094
97Inositol phosphate metabolism_Homo sapiens_hsa005620.47803284
98Wnt signaling pathway_Homo sapiens_hsa043100.47115626
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.45575314
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.43498235
101Endometrial cancer_Homo sapiens_hsa052130.43156115
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42189252
103Nitrogen metabolism_Homo sapiens_hsa009100.41731870
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.40510146
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40361131
106Peroxisome_Homo sapiens_hsa041460.39220625
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.38389238
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38115559
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37166456
110AMPK signaling pathway_Homo sapiens_hsa041520.36926830
111Lysine degradation_Homo sapiens_hsa003100.36462906
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35809254
113Alcoholism_Homo sapiens_hsa050340.35807886
114Type I diabetes mellitus_Homo sapiens_hsa049400.35316595
115ABC transporters_Homo sapiens_hsa020100.33195843
116Hippo signaling pathway_Homo sapiens_hsa043900.31026922
117Ovarian steroidogenesis_Homo sapiens_hsa049130.30265949
118Tight junction_Homo sapiens_hsa045300.27923260
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27227205
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26936344
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26380061
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25929677
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25824356
124Melanoma_Homo sapiens_hsa052180.25484368
125Insulin signaling pathway_Homo sapiens_hsa049100.22861201
126Phagosome_Homo sapiens_hsa041450.22824195
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22009335
128mTOR signaling pathway_Homo sapiens_hsa041500.20796111
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20079401
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19586113
131Prion diseases_Homo sapiens_hsa050200.19345754
132Chemokine signaling pathway_Homo sapiens_hsa040620.18463433
133Mineral absorption_Homo sapiens_hsa049780.18145655
134Renal cell carcinoma_Homo sapiens_hsa052110.18074703

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