KCNH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.32725827
2neuron cell-cell adhesion (GO:0007158)5.52930309
3axon ensheathment in central nervous system (GO:0032291)5.34130560
4central nervous system myelination (GO:0022010)5.34130560
5nonmotile primary cilium assembly (GO:0035058)5.19025139
6presynaptic membrane organization (GO:0097090)4.96549601
7response to pheromone (GO:0019236)4.80473581
8nucleobase catabolic process (GO:0046113)4.61140293
9forebrain neuron differentiation (GO:0021879)4.56530563
10negative regulation of microtubule polymerization (GO:0031115)4.53047419
11righting reflex (GO:0060013)4.52004898
12cell migration in hindbrain (GO:0021535)4.43417516
13regulation of chemokine-mediated signaling pathway (GO:0070099)4.39459623
14establishment of mitochondrion localization (GO:0051654)4.11469670
15transmission of nerve impulse (GO:0019226)4.11239628
16neuron recognition (GO:0008038)4.08014370
17neuronal ion channel clustering (GO:0045161)4.06195302
18gamma-aminobutyric acid transport (GO:0015812)4.00459278
19protein localization to synapse (GO:0035418)3.91761076
20regulation of timing of cell differentiation (GO:0048505)3.90481380
21hippocampus development (GO:0021766)3.90163574
22detection of calcium ion (GO:0005513)3.90161725
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.88724487
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.83422429
25negative regulation of oligodendrocyte differentiation (GO:0048715)3.81727400
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80477398
27regulation of respiratory system process (GO:0044065)3.79249681
28ganglion development (GO:0061548)3.76769324
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69920719
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68768002
31synaptic vesicle maturation (GO:0016188)3.66600025
32spinal cord development (GO:0021510)3.60626699
33locomotory exploration behavior (GO:0035641)3.57706546
34protein polyglutamylation (GO:0018095)3.54499695
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.50871890
36dendritic spine morphogenesis (GO:0060997)3.50763852
37axonal fasciculation (GO:0007413)3.50752648
38synaptic transmission, glutamatergic (GO:0035249)3.48581786
39postsynaptic membrane organization (GO:0001941)3.48142336
40regulation of development, heterochronic (GO:0040034)3.47797416
41glutamate receptor signaling pathway (GO:0007215)3.47637147
42regulation of chromatin binding (GO:0035561)3.47060749
43reflex (GO:0060004)3.46743718
44neuronal action potential propagation (GO:0019227)3.44401002
45central nervous system projection neuron axonogenesis (GO:0021952)3.43320596
46startle response (GO:0001964)3.42311169
47cerebellar Purkinje cell differentiation (GO:0021702)3.41808070
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.39482127
49synaptic vesicle exocytosis (GO:0016079)3.38673875
50glutamate secretion (GO:0014047)3.38454837
51innervation (GO:0060384)3.38071054
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.37273688
53urogenital system development (GO:0001655)3.36654540
54neurofilament cytoskeleton organization (GO:0060052)3.35226195
55adult walking behavior (GO:0007628)3.34229579
56neuronal action potential (GO:0019228)3.29985827
57cornea development in camera-type eye (GO:0061303)3.28366338
58exploration behavior (GO:0035640)3.26127094
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25915522
60vocalization behavior (GO:0071625)3.25063634
61glycine transport (GO:0015816)3.24799149
62cerebral cortex radially oriented cell migration (GO:0021799)3.22501103
63axon extension (GO:0048675)3.21000326
64mitochondrion transport along microtubule (GO:0047497)3.18080564
65establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.18080564
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17408826
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.17235105
68regulation of translation, ncRNA-mediated (GO:0045974)3.17235105
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17235105
70neuron-neuron synaptic transmission (GO:0007270)3.16241667
71intraciliary transport (GO:0042073)3.15129587
72regulation of respiratory gaseous exchange (GO:0043576)3.09343229
73neurotransmitter secretion (GO:0007269)3.04285190
74membrane depolarization during action potential (GO:0086010)3.04182392
75response to auditory stimulus (GO:0010996)3.02851927
76regulation of NFAT protein import into nucleus (GO:0051532)3.02419250
77thalamus development (GO:0021794)3.02075401
78negative chemotaxis (GO:0050919)3.01756206
79facial nerve structural organization (GO:0021612)3.01529600
80regulation of synaptic vesicle exocytosis (GO:2000300)3.00723408
81mammary gland epithelial cell differentiation (GO:0060644)2.99963062
82regulation of synapse structural plasticity (GO:0051823)2.98618587
83sensory perception of smell (GO:0007608)2.97786786
84regulation of collateral sprouting (GO:0048670)2.96721938
85olfactory bulb development (GO:0021772)2.96409286
86neuromuscular synaptic transmission (GO:0007274)2.95935074
87chaperone-mediated protein transport (GO:0072321)2.94155506
88neurotransmitter-gated ion channel clustering (GO:0072578)2.93768117
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93598210
90axoneme assembly (GO:0035082)2.92721660
91cell proliferation in forebrain (GO:0021846)2.91649087
92detection of mechanical stimulus involved in sensory perception (GO:0050974)2.91264252
93regulation of glutamate receptor signaling pathway (GO:1900449)2.90707952
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.90179362
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89233741
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88011917
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87729084
98glycosphingolipid biosynthetic process (GO:0006688)2.87602778
99synapse organization (GO:0050808)2.87075028
100negative regulation of axon extension involved in axon guidance (GO:0048843)2.86895147
101sensory perception of taste (GO:0050909)2.84978430
102behavioral response to ethanol (GO:0048149)2.84585340
103cerebellar granule cell differentiation (GO:0021707)2.84309370
104sensory perception of chemical stimulus (GO:0007606)2.83526155
105dendrite morphogenesis (GO:0048813)2.83151141
106inner ear receptor stereocilium organization (GO:0060122)2.83131839
107membrane hyperpolarization (GO:0060081)2.83020477
108mechanosensory behavior (GO:0007638)2.82534001
109negative regulation of axonogenesis (GO:0050771)2.81890233
110bone trabecula formation (GO:0060346)2.81082236
111positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.80516883
112positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80320511
113regulation of synaptic vesicle transport (GO:1902803)2.79086632
114substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.78623337
115substrate-independent telencephalic tangential migration (GO:0021826)2.78623337
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78035052
117positive regulation of oligodendrocyte differentiation (GO:0048714)2.77918403
118protein insertion into membrane (GO:0051205)2.77866785
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.77494983
120central nervous system neuron axonogenesis (GO:0021955)2.76700272
121spinal cord motor neuron differentiation (GO:0021522)2.76695668
122cerebral cortex neuron differentiation (GO:0021895)2.76245188
123presynaptic membrane assembly (GO:0097105)2.75605921
124regulation of synaptic transmission, GABAergic (GO:0032228)2.75124131
125negative regulation of sodium ion transport (GO:0010766)2.74294060
126behavioral fear response (GO:0001662)2.74082925
127behavioral defense response (GO:0002209)2.74082925
128cilium assembly (GO:0042384)2.73942559
129melanosome localization (GO:0032400)2.73703927
130auditory receptor cell stereocilium organization (GO:0060088)2.72519827
131positive regulation of synapse assembly (GO:0051965)2.71640791
132homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.70753258
133behavioral response to nicotine (GO:0035095)2.70415342
134spinal cord association neuron differentiation (GO:0021527)2.69344802
135neuron projection extension (GO:1990138)2.68646462
136auditory behavior (GO:0031223)2.67644322
137neural tube formation (GO:0001841)2.67305607
138regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67060456
139microtubule severing (GO:0051013)2.64568286
140protein localization to cilium (GO:0061512)2.64283807
141sensory perception of pain (GO:0019233)2.62379025
142limb bud formation (GO:0060174)2.61449004
143positive regulation of membrane potential (GO:0045838)2.61010887
144retinal ganglion cell axon guidance (GO:0031290)2.60319414
145axonogenesis (GO:0007409)2.60103052
146pigment granule localization (GO:0051875)2.59950467
147adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.59249588
148cell differentiation in hindbrain (GO:0021533)2.58769678
149synaptic vesicle endocytosis (GO:0048488)2.58277565
150cranial nerve structural organization (GO:0021604)2.56949332
151synapse assembly (GO:0007416)2.56477925
152adult behavior (GO:0030534)2.56395628
153regulation of synapse maturation (GO:0090128)2.55472069
154sympathetic nervous system development (GO:0048485)2.55028775
155positive regulation of filopodium assembly (GO:0051491)2.54978071
156establishment of melanosome localization (GO:0032401)2.54594749
157forebrain neuron development (GO:0021884)2.54574348
158cell differentiation in spinal cord (GO:0021515)2.54302733
159negative regulation of glial cell differentiation (GO:0045686)2.54279840
160protein localization to microtubule cytoskeleton (GO:0072698)2.54107969
161melanosome transport (GO:0032402)2.53908202
162regulation of oligodendrocyte differentiation (GO:0048713)2.53749121
163cilium organization (GO:0044782)2.53739960
164central nervous system neuron differentiation (GO:0021953)2.53505971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16790857
2GBX2_23144817_ChIP-Seq_PC3_Human4.00215393
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11262922
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.73707779
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.57541765
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55398365
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52575356
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52575356
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.49938033
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42002000
11TAF15_26573619_Chip-Seq_HEK293_Human2.35589239
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.33152364
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.32816507
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30554312
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.30515231
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29983938
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29446232
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23927343
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20128094
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16756605
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.09429737
22RNF2_27304074_Chip-Seq_NSC_Mouse2.07872604
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04194912
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00484030
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.96365922
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95479168
27IGF1R_20145208_ChIP-Seq_DFB_Human1.89837470
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82603520
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77935141
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75504716
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75024259
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71996693
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69342586
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67671176
35AR_21572438_ChIP-Seq_LNCaP_Human1.64862929
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.58063012
37P300_19829295_ChIP-Seq_ESCs_Human1.54665343
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54574863
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52479504
40* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47538301
41FUS_26573619_Chip-Seq_HEK293_Human1.44701664
42* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43676665
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43557943
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42920559
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.41769475
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.39316278
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.37429822
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36723232
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36682391
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35949422
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35282041
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.35241527
53AHR_22903824_ChIP-Seq_MCF-7_Human1.33195425
54ZNF274_21170338_ChIP-Seq_K562_Hela1.32721472
55VDR_22108803_ChIP-Seq_LS180_Human1.31818297
56* PIAS1_25552417_ChIP-Seq_VCAP_Human1.31336110
57DROSHA_22980978_ChIP-Seq_HELA_Human1.31187261
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28790724
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.25205989
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23576203
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22768303
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22266006
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.18652222
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18063577
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17635648
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17635648
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15903932
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15749414
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14564957
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.14348257
71EWS_26573619_Chip-Seq_HEK293_Human1.12010994
72STAT3_23295773_ChIP-Seq_U87_Human1.11595865
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11165230
74RUNX2_22187159_ChIP-Seq_PCA_Human1.10630697
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10593462
76ER_23166858_ChIP-Seq_MCF-7_Human1.09983283
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.09530610
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09359555
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08276405
80* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07435894
81* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06675162
82* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05636910
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.05084096
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04825545
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.04787739
86* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04478196
87AR_19668381_ChIP-Seq_PC3_Human1.04286279
88* CBP_20019798_ChIP-Seq_JUKART_Human1.04253065
89* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04253065
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03804540
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03205109
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01716120
93KDM2B_26808549_Chip-Seq_REH_Human1.01428107
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00471556
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00125685
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.00049494
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99953937
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99833695
99* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99702555
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.99607272
101BCAT_22108803_ChIP-Seq_LS180_Human0.99597173
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99301555
103* AR_25329375_ChIP-Seq_VCAP_Human0.98942011
104* SOX9_26525672_Chip-Seq_HEART_Mouse0.98704538
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98395757
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98068194
107* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97849706
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97327212
109P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96891122
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96234720
111P53_22387025_ChIP-Seq_ESCs_Mouse0.96131758
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.95876300
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95294005
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94976499
115PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94767447
116ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93565939
117TCF4_23295773_ChIP-Seq_U87_Human0.91187729
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91147270
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90037236
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89841094
121RARB_27405468_Chip-Seq_BRAIN_Mouse0.87390927
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86799926
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.86715706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol3.78839822
2MP0006276_abnormal_autonomic_nervous3.49907128
3MP0001984_abnormal_olfaction3.30293114
4MP0000778_abnormal_nervous_system3.01362329
5MP0003122_maternal_imprinting2.89132097
6MP0003880_abnormal_central_pattern2.69618611
7MP0008789_abnormal_olfactory_epithelium2.64166517
8MP0004858_abnormal_nervous_system2.61053812
9MP0002184_abnormal_innervation2.57460207
10MP0005423_abnormal_somatic_nervous2.29737108
11MP0005499_abnormal_olfactory_system2.29557567
12MP0005394_taste/olfaction_phenotype2.29557567
13MP0002102_abnormal_ear_morphology2.29410636
14MP0002557_abnormal_social/conspecific_i2.20852201
15MP0004270_analgesia2.18661374
16MP0002638_abnormal_pupillary_reflex2.17568309
17MP0004859_abnormal_synaptic_plasticity2.12945260
18MP0001529_abnormal_vocalization2.10865743
19MP0009046_muscle_twitch2.07664742
20MP0003183_abnormal_peptide_metabolism2.03686372
21MP0001486_abnormal_startle_reflex2.03103516
22MP0003941_abnormal_skin_development1.97200879
23MP0002734_abnormal_mechanical_nocicepti1.96521792
24MP0001968_abnormal_touch/_nociception1.95059013
25MP0004885_abnormal_endolymph1.93228876
26MP0002736_abnormal_nociception_after1.91603974
27MP0010386_abnormal_urinary_bladder1.91366185
28MP0003635_abnormal_synaptic_transmissio1.87518823
29MP0004742_abnormal_vestibular_system1.86715324
30MP0002733_abnormal_thermal_nociception1.78806580
31MP0010030_abnormal_orbit_morphology1.72238085
32MP0002067_abnormal_sensory_capabilities1.65716716
33MP0002735_abnormal_chemical_nociception1.65163492
34MP0002063_abnormal_learning/memory/cond1.64170543
35MP0003136_yellow_coat_color1.62776642
36MP0002822_catalepsy1.62706032
37MP0002272_abnormal_nervous_system1.62061759
38MP0000955_abnormal_spinal_cord1.59447245
39MP0006072_abnormal_retinal_apoptosis1.58063535
40MP0005167_abnormal_blood-brain_barrier1.57605678
41MP0002751_abnormal_autonomic_nervous1.54402695
42MP0003121_genomic_imprinting1.51979030
43MP0001970_abnormal_pain_threshold1.51693195
44MP0004133_heterotaxia1.50023634
45MP0002938_white_spotting1.47978037
46MP0002572_abnormal_emotion/affect_behav1.45705897
47MP0004142_abnormal_muscle_tone1.43282864
48MP0003283_abnormal_digestive_organ1.41140970
49MP0001188_hyperpigmentation1.41138698
50MP0004811_abnormal_neuron_physiology1.39549020
51MP0000566_synostosis1.39247480
52MP0002882_abnormal_neuron_morphology1.37382944
53MP0002909_abnormal_adrenal_gland1.34513335
54MP0006292_abnormal_olfactory_placode1.33831579
55MP0002752_abnormal_somatic_nervous1.31970447
56MP0002249_abnormal_larynx_morphology1.31361888
57MP0000631_abnormal_neuroendocrine_gland1.30230279
58MP0008877_abnormal_DNA_methylation1.27062243
59MP0009745_abnormal_behavioral_response1.25390936
60MP0001502_abnormal_circadian_rhythm1.25317905
61MP0005646_abnormal_pituitary_gland1.23847838
62MP0001501_abnormal_sleep_pattern1.23324759
63MP0009697_abnormal_copulation1.20629749
64MP0001986_abnormal_taste_sensitivity1.19619639
65MP0000026_abnormal_inner_ear1.18572781
66MP0001963_abnormal_hearing_physiology1.18093005
67MP0003861_abnormal_nervous_system1.17641032
68MP0001485_abnormal_pinna_reflex1.16951973
69MP0000049_abnormal_middle_ear1.15786158
70MP0003890_abnormal_embryonic-extraembry1.14998037
71MP0008569_lethality_at_weaning1.14875333
72MP0002152_abnormal_brain_morphology1.14753402
73MP0002064_seizures1.13425502
74MP0001905_abnormal_dopamine_level1.13221280
75MP0001440_abnormal_grooming_behavior1.11987369
76MP0003938_abnormal_ear_development1.10994462
77MP0000538_abnormal_urinary_bladder1.10260154
78MP0002234_abnormal_pharynx_morphology1.09513181
79MP0002653_abnormal_ependyma_morphology1.08762014
80MP0003119_abnormal_digestive_system1.06459781
81MP0008995_early_reproductive_senescence1.05519309
82MP0003633_abnormal_nervous_system1.04062382
83MP0004924_abnormal_behavior1.02602288
84MP0005386_behavior/neurological_phenoty1.02602288
85MP0001270_distended_abdomen1.02469587
86MP0003123_paternal_imprinting1.02255244
87MP0002277_abnormal_respiratory_mucosa1.01086747
88MP0005377_hearing/vestibular/ear_phenot0.99897770
89MP0003878_abnormal_ear_physiology0.99897770
90MP0000462_abnormal_digestive_system0.99640464
91MP0005551_abnormal_eye_electrophysiolog0.95288172
92MP0003690_abnormal_glial_cell0.94708454
93MP0003631_nervous_system_phenotype0.94414432
94MP0005195_abnormal_posterior_eye0.94126691
95MP0001346_abnormal_lacrimal_gland0.94105778
96MP0002066_abnormal_motor_capabilities/c0.93558590
97MP0003879_abnormal_hair_cell0.92861929
98MP0000920_abnormal_myelination0.90962280
99MP0003632_abnormal_nervous_system0.90259122
100MP0008057_abnormal_DNA_replication0.89442330
101MP0002160_abnormal_reproductive_system0.89299970
102MP0002233_abnormal_nose_morphology0.88542554
103MP0003787_abnormal_imprinting0.87630590
104MP0002116_abnormal_craniofacial_bone0.86216039
105MP0000372_irregular_coat_pigmentation0.86147696
106MP0005410_abnormal_fertilization0.80035824
107MP0002069_abnormal_eating/drinking_beha0.77734567
108MP0003634_abnormal_glial_cell0.77345988
109MP0002229_neurodegeneration0.76130456
110MP0005187_abnormal_penis_morphology0.74683844
111MP0003755_abnormal_palate_morphology0.74494172
112MP0001177_atelectasis0.73119779
113MP0003942_abnormal_urinary_system0.71295003
114MP0005253_abnormal_eye_physiology0.70591267
115MP0002081_perinatal_lethality0.69908733
116MP0004145_abnormal_muscle_electrophysio0.67646897
117MP0001293_anophthalmia0.67388048
118MP0000534_abnormal_ureter_morphology0.67127081
119MP0001299_abnormal_eye_distance/0.66773727
120MP0001943_abnormal_respiration0.66664356
121MP0003329_amyloid_beta_deposits0.66084498
122MP0003137_abnormal_impulse_conducting0.64719585
123MP0003868_abnormal_feces_composition0.64554711
124MP0000569_abnormal_digit_pigmentation0.63867853
125MP0000427_abnormal_hair_cycle0.63457264

Predicted human phenotypes

RankGene SetZ-score
1Split foot (HP:0001839)6.37086796
2Oligodactyly (hands) (HP:0001180)4.61760820
3Absent hand (HP:0004050)4.08483468
4Congenital sensorineural hearing impairment (HP:0008527)3.94153634
5Hypothermia (HP:0002045)3.90192012
6Failure to thrive in infancy (HP:0001531)3.76638881
7Focal motor seizures (HP:0011153)3.65650334
8Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.56963914
9Oligodactyly (HP:0012165)3.51890464
10Facial cleft (HP:0002006)3.51452025
11Progressive cerebellar ataxia (HP:0002073)3.43360605
12Atonic seizures (HP:0010819)3.42652368
13Drooling (HP:0002307)3.40877799
14Polyphagia (HP:0002591)3.34789590
15Hyperventilation (HP:0002883)3.16925761
16Excessive salivation (HP:0003781)3.14619906
17Epileptic encephalopathy (HP:0200134)3.12155505
18Fibular aplasia (HP:0002990)3.11119133
19Limb dystonia (HP:0002451)3.09243590
20Morphological abnormality of the middle ear (HP:0008609)3.07853170
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.05111571
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.05111571
23Hypomagnesemia (HP:0002917)2.99269175
24Intellectual disability, moderate (HP:0002342)2.98058272
25Myokymia (HP:0002411)2.94241410
26Genetic anticipation (HP:0003743)2.93802874
27Median cleft lip (HP:0000161)2.87996089
28Bifid tongue (HP:0010297)2.87244589
29Peripheral hypomyelination (HP:0007182)2.80500373
30Dialeptic seizures (HP:0011146)2.77778268
31Severe visual impairment (HP:0001141)2.74891481
32Action tremor (HP:0002345)2.72804119
33Pancreatic fibrosis (HP:0100732)2.71408451
34Cutaneous syndactyly (HP:0012725)2.69695459
35Progressive sensorineural hearing impairment (HP:0000408)2.66693084
36Hepatoblastoma (HP:0002884)2.64963291
37Cutaneous finger syndactyly (HP:0010554)2.64371528
38Spastic gait (HP:0002064)2.58772089
39Agitation (HP:0000713)2.57247210
40Abnormality of macular pigmentation (HP:0008002)2.53953088
41Esotropia (HP:0000565)2.53255926
42Symptomatic seizures (HP:0011145)2.52210858
43Generalized hypotonia (HP:0001290)2.49792244
44Generalized tonic-clonic seizures (HP:0002069)2.48594748
45Chronic hepatic failure (HP:0100626)2.48388799
46Urinary bladder sphincter dysfunction (HP:0002839)2.47549066
47Abnormality of magnesium homeostasis (HP:0004921)2.47049419
48Nephronophthisis (HP:0000090)2.46930958
49Absence seizures (HP:0002121)2.42489480
50Molar tooth sign on MRI (HP:0002419)2.41302370
51Abnormality of midbrain morphology (HP:0002418)2.41302370
52Gait imbalance (HP:0002141)2.41293517
53Lissencephaly (HP:0001339)2.41078883
54Absent eyebrow (HP:0002223)2.40413471
55Genital tract atresia (HP:0001827)2.36830516
56Pachygyria (HP:0001302)2.36616692
57Medial flaring of the eyebrow (HP:0010747)2.35069960
58Severe Myopia (HP:0011003)2.34801578
59Specific learning disability (HP:0001328)2.33534738
60Poor suck (HP:0002033)2.30979313
61Hemiparesis (HP:0001269)2.30901112
62Hypoplasia of the brainstem (HP:0002365)2.30802329
63Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30802329
64Sex reversal (HP:0012245)2.29666343
65Abnormal sex determination (HP:0012244)2.29666343
66Megalencephaly (HP:0001355)2.29076726
67Febrile seizures (HP:0002373)2.29019808
68Tubulointerstitial nephritis (HP:0001970)2.27761140
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26532619
70Epileptiform EEG discharges (HP:0011182)2.24997726
71Labial hypoplasia (HP:0000066)2.22759822
72Hyperphosphatemia (HP:0002905)2.19278567
73Hypoglycemic seizures (HP:0002173)2.17336922
74Urinary urgency (HP:0000012)2.17317191
75Myelomeningocele (HP:0002475)2.17021454
76Aplasia/Hypoplasia of the lens (HP:0008063)2.16547359
77Hypsarrhythmia (HP:0002521)2.16422631
78Nephrogenic diabetes insipidus (HP:0009806)2.16103165
79Vaginal atresia (HP:0000148)2.16061006
80Abnormality of the labia minora (HP:0012880)2.16026064
81Postaxial hand polydactyly (HP:0001162)2.15571345
82Thyroid-stimulating hormone excess (HP:0002925)2.15336576
83Intestinal atresia (HP:0011100)2.15150829
84Inability to walk (HP:0002540)2.14911317
85Sleep apnea (HP:0010535)2.14622894
86EEG with generalized epileptiform discharges (HP:0011198)2.14524775
87Abnormal eating behavior (HP:0100738)2.14480034
88Ankle clonus (HP:0011448)2.13857548
89Abnormality of the corticospinal tract (HP:0002492)2.13499806
90True hermaphroditism (HP:0010459)2.12897848
91Abnormality of the renal medulla (HP:0100957)2.11533773
92Broad-based gait (HP:0002136)2.11125701
93Hypoplasia of the fovea (HP:0007750)2.10443229
94Aplasia/Hypoplasia of the fovea (HP:0008060)2.10443229
95Aqueductal stenosis (HP:0002410)2.09521513
96Exotropia (HP:0000577)2.09182260
97Abnormality of the fovea (HP:0000493)2.08655742
98Bilateral microphthalmos (HP:0007633)2.08470640
99Spastic tetraplegia (HP:0002510)2.03849584
100Optic nerve hypoplasia (HP:0000609)2.03406090
101Protruding tongue (HP:0010808)2.03103483
102Ectopic anus (HP:0004397)2.03071179
103Abnormal hair whorl (HP:0010721)2.01492446
104Abnormality of the pubic bones (HP:0003172)2.01121853
105Bradycardia (HP:0001662)2.01023005
106Congenital primary aphakia (HP:0007707)1.97441393
107Anterior segment dysgenesis (HP:0007700)1.96549508
108Focal seizures (HP:0007359)1.96412079
109Status epilepticus (HP:0002133)1.95038749
110Ulnar claw (HP:0001178)1.94037264
111Anencephaly (HP:0002323)1.93619073
112Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.92917289
113Hypoplastic female external genitalia (HP:0012815)1.92064686
114Omphalocele (HP:0001539)1.91604746
115Septo-optic dysplasia (HP:0100842)1.91405867
116Congenital hepatic fibrosis (HP:0002612)1.91058375
117Retinal dysplasia (HP:0007973)1.91003026
118Pancreatic cysts (HP:0001737)1.90790794
119Hypoplasia of the corpus callosum (HP:0002079)1.90414115
120Preaxial hand polydactyly (HP:0001177)1.90251035
121Morphological abnormality of the pyramidal tract (HP:0002062)1.89757848
122Osteomalacia (HP:0002749)1.88668087
123Growth hormone deficiency (HP:0000824)1.88579378
124Gaze-evoked nystagmus (HP:0000640)1.88415659
125Absent speech (HP:0001344)1.88197023
126Torticollis (HP:0000473)1.88171843
127Lower limb muscle weakness (HP:0007340)1.88144451
128Absent eyelashes (HP:0000561)1.87607661
129Congenital stationary night blindness (HP:0007642)1.86902969
130Narrow forehead (HP:0000341)1.86721186
131Postaxial foot polydactyly (HP:0001830)1.86032526
132Esophageal atresia (HP:0002032)1.85862337
133Abnormality of salivation (HP:0100755)1.85064620
134Absent forearm bone (HP:0003953)1.84380319
135Aplasia involving forearm bones (HP:0009822)1.84380319
136Abdominal situs inversus (HP:0003363)1.84304152
137Abnormality of abdominal situs (HP:0011620)1.84304152
138Intellectual disability, severe (HP:0010864)1.83179419
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.82933249
140Amblyopia (HP:0000646)1.82858623
141Tented upper lip vermilion (HP:0010804)1.80867715
142Impaired vibration sensation in the lower limbs (HP:0002166)1.80741094
143Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80054623
144Meningocele (HP:0002435)1.79288410
145Amyotrophic lateral sclerosis (HP:0007354)1.77881745
146Abnormality of pain sensation (HP:0010832)1.77465718
147Impaired pain sensation (HP:0007328)1.77465718
148Abnormality of calcium-phosphate metabolism (HP:0100530)1.76043391
149Occipital encephalocele (HP:0002085)1.73907668
150Hypoplastic pelvis (HP:0008839)1.73846369
151Hip dysplasia (HP:0001385)1.73113232
152Elfin facies (HP:0004428)1.73063113
153Cortical dysplasia (HP:0002539)1.72957425
154Abnormality of the antihelix (HP:0009738)1.71787917
155Cystic liver disease (HP:0006706)1.71563276
156Supranuclear gaze palsy (HP:0000605)1.69112395
157Abnormality of the intervertebral disk (HP:0005108)1.68374311
158Anophthalmia (HP:0000528)1.65568023
159Gastrointestinal atresia (HP:0002589)1.64403614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.77762806
2MAP3K93.84571579
3MARK13.48852002
4INSRR3.45433069
5EPHA43.24965362
6ACVR1B3.06179078
7NTRK22.53430331
8MAPK132.27596384
9DYRK22.22778194
10SRPK12.22761397
11WNK32.20777119
12MAP3K42.09646932
13UHMK12.07292622
14PHKG12.04268604
15PHKG22.04268604
16MAP2K72.01137004
17GRK12.00500148
18NTRK31.85941031
19BCR1.76576340
20MAP3K121.73401341
21ERBB31.65608595
22TYRO31.63114317
23PRKD31.61454449
24PNCK1.57339333
25CDK191.56306263
26MINK11.53185695
27FRK1.41136037
28SIK31.33389726
29PDGFRA1.29835134
30PINK11.29334571
31CAMKK11.23119146
32IRAK11.22778119
33RPS6KA21.17425117
34TESK21.15456998
35SGK4941.14806366
36SGK2231.14806366
37CAMK11.10301314
38PAK31.08878569
39SGK21.07460215
40HIPK21.01026509
41STK111.00308865
42BMPR1B0.99151962
43MAP4K20.95623871
44DDR20.94818799
45OXSR10.93652912
46EPHB20.90192094
47PRKCG0.89023285
48CSNK1A1L0.87868759
49EPHA30.86916001
50MAP2K40.86065875
51TNIK0.84771563
52MAPK150.84769895
53CAMKK20.84462405
54ARAF0.83335254
55AKT30.80710723
56TESK10.80217081
57BRD40.78167011
58LIMK10.77014440
59TLK10.75216979
60ERBB40.74948078
61CDK50.72431336
62ICK0.71326628
63RET0.70452445
64NTRK10.70223004
65WNK40.69782913
66CSNK1G10.67961515
67TNK20.67007227
68PAK60.65470769
69CSNK1G20.64462577
70ADRBK10.63030663
71TRIM280.62291301
72NUAK10.61704014
73PRKCE0.58903788
74CSNK1G30.58107301
75DYRK1A0.57525555
76CAMK1G0.56664375
77IRAK20.55860058
78CSNK1E0.55381105
79BLK0.54584756
80CAMK40.54211452
81STK240.54194908
82MAP2K20.53682691
83AKT20.51867006
84MAPK100.51770946
85MKNK20.51248238
86PRKAA10.50628732
87BRAF0.50246807
88DYRK1B0.49587005
89PRKCZ0.49343400
90KSR10.49049832
91ZAK0.48886395
92RPS6KA30.47217039
93CDK30.47204846
94PRKG10.47047014
95BMPR20.46957778
96PRKCH0.46752038
97CDK150.44668565
98CAMK2B0.43250080
99CDK11A0.43242102
100STK390.42205763
101FER0.41611110
102SIK20.41585112
103PLK20.41404538
104PKN10.40267210
105CAMK2G0.39981178
106FGFR40.39962009
107CSNK1A10.39852103
108GSK3B0.38799219
109LATS10.38784583
110ERBB20.38659015
111MAPK80.38562422
112SGK10.38314771
113GRK50.38242488
114CSNK1D0.38230886
115GRK70.38190764
116YES10.37409918
117WNK10.37354763
118CAMK1D0.37244997
119MKNK10.36572811
120PIK3CG0.36515145
121PLK40.36391561
122SGK30.34803299
123CDC42BPA0.34444812
124MAP2K10.34053757
125PRKACA0.33816849
126MAPK40.33681649
127ADRBK20.33600946
128CAMK2A0.33595237
129DYRK30.33563251
130FGFR20.33136333
131CDK180.32790695
132MAP3K10.31641556
133MAP3K130.31208180
134CDK140.31059904
135AURKA0.29713417
136DAPK20.27276785
137CAMK2D0.26833181
138MARK20.26742784

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.71395265
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.90491410
3Taste transduction_Homo sapiens_hsa047422.61349552
4Axon guidance_Homo sapiens_hsa043602.60705680
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.60490135
6Insulin secretion_Homo sapiens_hsa049112.55762221
7Nicotine addiction_Homo sapiens_hsa050332.32868773
8Phototransduction_Homo sapiens_hsa047442.02776372
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98031861
10Morphine addiction_Homo sapiens_hsa050321.91078326
11Cholinergic synapse_Homo sapiens_hsa047251.84615399
12Synaptic vesicle cycle_Homo sapiens_hsa047211.81042184
13Dopaminergic synapse_Homo sapiens_hsa047281.80738970
14Serotonergic synapse_Homo sapiens_hsa047261.78979602
15GABAergic synapse_Homo sapiens_hsa047271.74893250
16Circadian entrainment_Homo sapiens_hsa047131.71361197
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70131217
18Glutamatergic synapse_Homo sapiens_hsa047241.70109825
19Hedgehog signaling pathway_Homo sapiens_hsa043401.59463301
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56741912
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53618000
22Sphingolipid metabolism_Homo sapiens_hsa006001.50986787
23Type II diabetes mellitus_Homo sapiens_hsa049301.44781577
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31816177
25Basal cell carcinoma_Homo sapiens_hsa052171.31193696
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29344822
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29148387
28Gap junction_Homo sapiens_hsa045401.24588100
29Cardiac muscle contraction_Homo sapiens_hsa042601.24198969
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20518732
31Butanoate metabolism_Homo sapiens_hsa006501.18510902
32Steroid biosynthesis_Homo sapiens_hsa001001.18447309
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18337759
34Linoleic acid metabolism_Homo sapiens_hsa005911.14853979
35Melanogenesis_Homo sapiens_hsa049161.12221389
36Alcoholism_Homo sapiens_hsa050341.09510485
37Cocaine addiction_Homo sapiens_hsa050301.08613799
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08156502
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08145119
40Protein export_Homo sapiens_hsa030601.06005891
41Wnt signaling pathway_Homo sapiens_hsa043101.05333296
42Amphetamine addiction_Homo sapiens_hsa050311.02299786
43ErbB signaling pathway_Homo sapiens_hsa040121.00109545
44Colorectal cancer_Homo sapiens_hsa052100.99435697
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98882169
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97531986
47Oxidative phosphorylation_Homo sapiens_hsa001900.96273671
48Calcium signaling pathway_Homo sapiens_hsa040200.93694652
49Vibrio cholerae infection_Homo sapiens_hsa051100.91733483
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91111250
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90173836
52Parkinsons disease_Homo sapiens_hsa050120.89168693
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88436226
54GnRH signaling pathway_Homo sapiens_hsa049120.88234283
55Endometrial cancer_Homo sapiens_hsa052130.87285062
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.86938805
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85994740
58Regulation of autophagy_Homo sapiens_hsa041400.85251571
59Dorso-ventral axis formation_Homo sapiens_hsa043200.84803100
60Alzheimers disease_Homo sapiens_hsa050100.84471570
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83348074
62Hippo signaling pathway_Homo sapiens_hsa043900.83324369
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81775188
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79471176
65cAMP signaling pathway_Homo sapiens_hsa040240.77596448
66Estrogen signaling pathway_Homo sapiens_hsa049150.75593978
67Rap1 signaling pathway_Homo sapiens_hsa040150.75179312
68Long-term depression_Homo sapiens_hsa047300.75051033
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74752088
70Long-term potentiation_Homo sapiens_hsa047200.74701517
71Renin secretion_Homo sapiens_hsa049240.74203163
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72960746
73Bile secretion_Homo sapiens_hsa049760.71103495
74Tight junction_Homo sapiens_hsa045300.70834174
75Glioma_Homo sapiens_hsa052140.69433897
76Prolactin signaling pathway_Homo sapiens_hsa049170.69298369
77Collecting duct acid secretion_Homo sapiens_hsa049660.68522905
78Ovarian steroidogenesis_Homo sapiens_hsa049130.66826599
79beta-Alanine metabolism_Homo sapiens_hsa004100.66090823
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.65064847
81Ras signaling pathway_Homo sapiens_hsa040140.64837921
82Glucagon signaling pathway_Homo sapiens_hsa049220.64235367
83MAPK signaling pathway_Homo sapiens_hsa040100.62673247
84Oxytocin signaling pathway_Homo sapiens_hsa049210.62457750
85Melanoma_Homo sapiens_hsa052180.61919627
86Basal transcription factors_Homo sapiens_hsa030220.61829439
87Huntingtons disease_Homo sapiens_hsa050160.61707481
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59542516
89Sulfur metabolism_Homo sapiens_hsa009200.58080906
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55142228
91Circadian rhythm_Homo sapiens_hsa047100.54689945
92Oocyte meiosis_Homo sapiens_hsa041140.54599686
93Pancreatic secretion_Homo sapiens_hsa049720.54527347
94Salivary secretion_Homo sapiens_hsa049700.53518009
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52640566
96Insulin signaling pathway_Homo sapiens_hsa049100.52092185
97Gastric acid secretion_Homo sapiens_hsa049710.51413148
98Phagosome_Homo sapiens_hsa041450.50934269
99Dilated cardiomyopathy_Homo sapiens_hsa054140.50873390
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50091480
101Hepatitis C_Homo sapiens_hsa051600.50057510
102Thyroid hormone synthesis_Homo sapiens_hsa049180.49106423
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47119687
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.46260007
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46192444
106ABC transporters_Homo sapiens_hsa020100.45065037
107Choline metabolism in cancer_Homo sapiens_hsa052310.44373830
108Type I diabetes mellitus_Homo sapiens_hsa049400.43283651
109Ether lipid metabolism_Homo sapiens_hsa005650.43052194
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42035073
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42020925
112Histidine metabolism_Homo sapiens_hsa003400.41554262
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41015535
114Notch signaling pathway_Homo sapiens_hsa043300.40565301
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.39996170
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39895948
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39131676
118Inositol phosphate metabolism_Homo sapiens_hsa005620.38249073
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36506615
120Lysine degradation_Homo sapiens_hsa003100.35723388
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34282246

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