KCNIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)5.32019990
2synaptic vesicle maturation (GO:0016188)5.14981261
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09154734
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02362707
5locomotory exploration behavior (GO:0035641)4.98177973
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.92666267
7regulation of cell communication by electrical coupling (GO:0010649)4.69253004
8vocalization behavior (GO:0071625)4.56100207
9cellular response to epinephrine stimulus (GO:0071872)4.54555542
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.54489243
11regulation of sequestering of triglyceride (GO:0010889)4.46821484
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.42175698
13regulation of glutamate receptor signaling pathway (GO:1900449)4.37068193
14triglyceride catabolic process (GO:0019433)4.35333148
15regulation of actin filament-based movement (GO:1903115)4.32055675
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.24320676
17synaptic vesicle exocytosis (GO:0016079)4.20522271
18NADH metabolic process (GO:0006734)4.14835030
19regulation of neuronal synaptic plasticity (GO:0048168)4.14227146
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13337430
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09181870
22negative regulation of cytosolic calcium ion concentration (GO:0051481)4.04274062
23acylglycerol catabolic process (GO:0046464)4.03726939
24neutral lipid catabolic process (GO:0046461)4.03726939
25striatum development (GO:0021756)4.02837384
26prepulse inhibition (GO:0060134)3.96228156
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.95607145
28low-density lipoprotein particle clearance (GO:0034383)3.95109925
29response to epinephrine (GO:0071871)3.94154297
30glutamate secretion (GO:0014047)3.88766266
31* detection of calcium ion (GO:0005513)3.87841459
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.86217599
33regulation of synaptic vesicle exocytosis (GO:2000300)3.84969546
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83544796
35cell communication involved in cardiac conduction (GO:0086065)3.82611486
36cell communication by electrical coupling (GO:0010644)3.81910160
37synaptic transmission, dopaminergic (GO:0001963)3.80192101
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.78507372
39neuronal action potential propagation (GO:0019227)3.77267418
40positive regulation of synaptic transmission, GABAergic (GO:0032230)3.76008147
41regulation of dendritic spine morphogenesis (GO:0061001)3.75302739
42protein localization to synapse (GO:0035418)3.71821214
43regulation of membrane repolarization (GO:0060306)3.69741436
44neurotransmitter-gated ion channel clustering (GO:0072578)3.69380205
45cGMP-mediated signaling (GO:0019934)3.68778187
46negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.66769146
47sarcomere organization (GO:0045214)3.64354898
48regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.62754249
49exploration behavior (GO:0035640)3.61605416
50cardiac muscle hypertrophy (GO:0003300)3.61000586
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.60917058
52activation of protein kinase A activity (GO:0034199)3.60225720
53regulation of synaptic vesicle transport (GO:1902803)3.60033536
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56281447
55membrane depolarization during action potential (GO:0086010)3.55603438
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.55047732
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54712527
58regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.54319755
59regulation of cardiac muscle cell contraction (GO:0086004)3.54276230
60dendritic spine morphogenesis (GO:0060997)3.53558397
61neuron-neuron synaptic transmission (GO:0007270)3.52284684
62synaptic transmission, glutamatergic (GO:0035249)3.51361235
63neurotransmitter secretion (GO:0007269)3.51244191
64cellular response to catecholamine stimulus (GO:0071870)3.50697802
65cellular response to monoamine stimulus (GO:0071868)3.50697802
66positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49816282
67myofibril assembly (GO:0030239)3.49085557
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48765025
69long-term memory (GO:0007616)3.48327719
70striated muscle hypertrophy (GO:0014897)3.47148317
71adenosine receptor signaling pathway (GO:0001973)3.46437545
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.45952613
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.44765098
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39733831
75neuromuscular process controlling balance (GO:0050885)3.36517490
76regulation of voltage-gated calcium channel activity (GO:1901385)3.35427643
77dopamine receptor signaling pathway (GO:0007212)3.33213844
78regulation of cAMP-dependent protein kinase activity (GO:2000479)3.32515671
79positive regulation of membrane potential (GO:0045838)3.31185514
80auditory behavior (GO:0031223)3.30673918
81regulation of synaptic plasticity (GO:0048167)3.30129992
82positive regulation of neurotransmitter transport (GO:0051590)3.30015166
83regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.29299478
84regulation of postsynaptic membrane potential (GO:0060078)3.29235993
85glutamate receptor signaling pathway (GO:0007215)3.28855159
86behavioral response to cocaine (GO:0048148)3.28298409
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.24440441
88regulation of glycogen (starch) synthase activity (GO:2000465)3.21409132
89cellular potassium ion homeostasis (GO:0030007)3.20434590
90ventricular cardiac muscle cell action potential (GO:0086005)3.20046385
91regulation of relaxation of muscle (GO:1901077)3.19768827
92sodium ion export (GO:0071436)3.18431127
93striated muscle contraction (GO:0006941)3.18104440
94response to dietary excess (GO:0002021)3.17834311
95layer formation in cerebral cortex (GO:0021819)3.17244597
96muscle filament sliding (GO:0030049)3.17023854
97actin-myosin filament sliding (GO:0033275)3.17023854
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16903715
99muscle hypertrophy (GO:0014896)3.16658079
100regulation of calcium ion transmembrane transport (GO:1903169)3.15820519
101regulation of calcium ion transmembrane transporter activity (GO:1901019)3.15820519
102regulation of the force of heart contraction (GO:0002026)3.15820506
103cardiac muscle contraction (GO:0060048)3.14723490
104response to amphetamine (GO:0001975)3.13922104
105regulation of synaptic transmission, glutamatergic (GO:0051966)3.13816955
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.13380483
107positive regulation of neurotransmitter secretion (GO:0001956)3.12825170
108cardiac conduction (GO:0061337)3.11602024
109regulation of female receptivity (GO:0045924)3.11564805
110response to catecholamine (GO:0071869)3.10372857
111response to monoamine (GO:0071867)3.10372857
112glycerolipid catabolic process (GO:0046503)3.09106908
113membrane depolarization (GO:0051899)3.08747697
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07264281
115cardiac myofibril assembly (GO:0055003)3.06382751
116creatine metabolic process (GO:0006600)3.06063573
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.99976751
118response to auditory stimulus (GO:0010996)2.99487678
119regulation of dendritic spine development (GO:0060998)2.99413530
120neuronal action potential (GO:0019228)2.98909104
121negative regulation of amino acid transport (GO:0051956)2.98370355
122behavioral fear response (GO:0001662)2.98135938
123behavioral defense response (GO:0002209)2.98135938
124regulation of striated muscle contraction (GO:0006942)2.98041989
125transmission of nerve impulse (GO:0019226)2.98026599
126plasma membrane repair (GO:0001778)2.97179584
127gamma-aminobutyric acid transport (GO:0015812)2.96456430
128regulation of glutamate secretion (GO:0014048)2.96452102
129cAMP biosynthetic process (GO:0006171)2.95678356
130negative regulation of dendrite morphogenesis (GO:0050774)2.95566781
131fatty acid homeostasis (GO:0055089)2.95370979
132potassium ion import (GO:0010107)2.93648583
133sarcoplasmic reticulum calcium ion transport (GO:0070296)2.93589643
134* regulation of ion transmembrane transporter activity (GO:0032412)2.91412828
135ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.91389771
136regulation of heart rate (GO:0002027)2.91184628
137regulation of synapse maturation (GO:0090128)2.90883718
138proline transport (GO:0015824)2.89229547
139long-term synaptic potentiation (GO:0060291)2.89036601
140multicellular organismal signaling (GO:0035637)2.88658740
141negative regulation of dendrite development (GO:2000171)2.88621702
142regulation of heart rate by cardiac conduction (GO:0086091)2.88501494
143cardiac muscle cell action potential involved in contraction (GO:0086002)2.87961674
144cardiac muscle cell action potential (GO:0086001)2.87901941
145negative regulation of calcium ion transmembrane transport (GO:1903170)2.87622640
146negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87622640
147fatty acid transmembrane transport (GO:1902001)2.83869504
148heart process (GO:0003015)2.81135009
149heart contraction (GO:0060047)2.81135009
150regulation of cardiac muscle contraction (GO:0055117)2.78400394
151positive regulation of potassium ion transport (GO:0043268)2.77736485
152lipid particle organization (GO:0034389)2.77622488
153positive regulation of synapse maturation (GO:0090129)2.77561718
154cardiac muscle hypertrophy in response to stress (GO:0014898)2.75540930
155muscle hypertrophy in response to stress (GO:0003299)2.75540930
156cardiac muscle adaptation (GO:0014887)2.75540930
157L-amino acid import (GO:0043092)2.74741159
158adrenergic receptor signaling pathway (GO:0071875)2.73875206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70697735
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.16034000
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.46292200
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05578218
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03881602
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86817690
7GBX2_23144817_ChIP-Seq_PC3_Human2.78177946
8DROSHA_22980978_ChIP-Seq_HELA_Human2.73354761
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71718920
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71718920
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62818782
12REST_21632747_ChIP-Seq_MESCs_Mouse2.58474130
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56718003
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50199474
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49785662
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48982279
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.41023438
18* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36865014
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24893332
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.24056385
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.23529110
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22057175
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.13403388
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12903821
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.07648900
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.92917280
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90846134
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90533074
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.77305106
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68776752
31AR_21572438_ChIP-Seq_LNCaP_Human1.65411236
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61636734
33* TBX20_22328084_ChIP-Seq_HEART_Mouse1.60221079
34* TBX20_22080862_ChIP-Seq_HEART_Mouse1.60221079
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55302900
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52765192
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.50414230
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.47719382
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46127089
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45897560
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42147108
42SMAD4_21799915_ChIP-Seq_A2780_Human1.41451343
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39451492
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37173953
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36895080
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35472402
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.34102191
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33818104
49KDM2B_26808549_Chip-Seq_K562_Human1.32545552
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31611070
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31325970
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29982247
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.29875083
54* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27945515
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.26202624
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23111781
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22787480
58* CTCF_27219007_Chip-Seq_Bcells_Human1.21891352
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20375917
60* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19734638
61TAF15_26573619_Chip-Seq_HEK293_Human1.16913001
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16826604
63* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16775987
64AR_19668381_ChIP-Seq_PC3_Human1.15462924
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13550754
66ZNF274_21170338_ChIP-Seq_K562_Hela1.13182005
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12593194
68SMC4_20622854_ChIP-Seq_HELA_Human1.11867886
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11712032
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10031793
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07948913
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05966810
73CLOCK_20551151_ChIP-Seq_293T_Human1.03073733
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02923650
75* SMAD3_21741376_ChIP-Seq_HESCs_Human1.02902398
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.02632728
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02094371
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01461810
79* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99101114
80STAT3_23295773_ChIP-Seq_U87_Human0.98744185
81AHR_22903824_ChIP-Seq_MCF-7_Human0.98493646
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98427770
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98117425
84* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97330044
85* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97215537
86RING1B_27294783_Chip-Seq_NPCs_Mouse0.95883000
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95386895
88* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95319694
89KLF4_19829295_ChIP-Seq_ESCs_Human0.95019689
90AR_25329375_ChIP-Seq_VCAP_Human0.94713437
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94452248
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93950781
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93243774
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90802740
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90560202
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89820103
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88940113
98OCT4_19829295_ChIP-Seq_ESCs_Human0.88906616
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88664126
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.88207546
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.87885366
102TCF4_23295773_ChIP-Seq_U87_Human0.87378077
103TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87060512
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85944728
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85901933
106P300_19829295_ChIP-Seq_ESCs_Human0.85150820
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85120117
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.85004031
109KDM2B_26808549_Chip-Seq_DND41_Human0.84968262
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.83988842
111RXR_22108803_ChIP-Seq_LS180_Human0.83166423
112* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82819124
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82404410
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.81727830
115* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81383912
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81021284
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80606120
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80455657
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80438364
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79821233
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.79342786
122LXR_22292898_ChIP-Seq_THP-1_Human0.78674378
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78232833
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.78066278
125BCAT_22108803_ChIP-Seq_LS180_Human0.77917540
126* TP53_20018659_ChIP-ChIP_R1E_Mouse0.77054500
127ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76911559
128P68_20966046_ChIP-Seq_HELA_Human0.74702921
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74501265
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.73966994
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73144526
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.72130420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.18375295
2MP0002822_catalepsy5.54061074
3MP0005670_abnormal_white_adipose5.22188904
4MP0003880_abnormal_central_pattern3.80725154
5MP0003635_abnormal_synaptic_transmissio3.64471679
6MP0002837_dystrophic_cardiac_calcinosis3.37524876
7MP0005666_abnormal_adipose_tissue3.29128251
8MP0004270_analgesia3.15322510
9MP0009745_abnormal_behavioral_response3.13567194
10MP0001968_abnormal_touch/_nociception3.05146212
11MP0002063_abnormal_learning/memory/cond2.97497333
12MP0000751_myopathy2.90269272
13MP0002064_seizures2.68103421
14MP0003646_muscle_fatigue2.63360005
15MP0004215_abnormal_myocardial_fiber2.51593035
16MP0002736_abnormal_nociception_after2.43448004
17MP0002572_abnormal_emotion/affect_behav2.37300831
18MP0002272_abnormal_nervous_system2.36815599
19MP0009046_muscle_twitch2.33301159
20MP0002735_abnormal_chemical_nociception2.29093746
21MP0005375_adipose_tissue_phenotype2.28040554
22MP0004084_abnormal_cardiac_muscle2.23483426
23MP0001486_abnormal_startle_reflex2.13433453
24MP0002734_abnormal_mechanical_nocicepti2.11566472
25MP0002909_abnormal_adrenal_gland2.09097578
26MP0002971_abnormal_brown_adipose2.06405731
27MP0004036_abnormal_muscle_relaxation1.95965294
28MP0005423_abnormal_somatic_nervous1.89210463
29MP0001970_abnormal_pain_threshold1.87761605
30MP0002733_abnormal_thermal_nociception1.86460613
31MP0001501_abnormal_sleep_pattern1.75226303
32MP0001529_abnormal_vocalization1.73547879
33MP0005386_behavior/neurological_phenoty1.68662057
34MP0004924_abnormal_behavior1.68662057
35MP0003828_pulmonary_edema1.64918641
36MP0001440_abnormal_grooming_behavior1.62216233
37* MP0004085_abnormal_heartbeat1.61431083
38MP0008569_lethality_at_weaning1.60282624
39MP0005330_cardiomyopathy1.59747330
40MP0009780_abnormal_chondrocyte_physiolo1.59540039
41MP0000749_muscle_degeneration1.59447511
42MP0004185_abnormal_adipocyte_glucose1.55846561
43* MP0003137_abnormal_impulse_conducting1.53156988
44MP0004858_abnormal_nervous_system1.50101402
45MP0002067_abnormal_sensory_capabilities1.49940240
46MP0004811_abnormal_neuron_physiology1.48752785
47MP0002972_abnormal_cardiac_muscle1.45583890
48MP0004484_altered_response_of1.44558288
49MP0005646_abnormal_pituitary_gland1.44047135
50MP0009115_abnormal_fat_cell1.43265933
51MP0003329_amyloid_beta_deposits1.41355897
52MP0004130_abnormal_muscle_cell1.39753050
53MP0005620_abnormal_muscle_contractility1.36725859
54MP0002638_abnormal_pupillary_reflex1.36091653
55MP0002557_abnormal_social/conspecific_i1.29807187
56MP0004510_myositis1.28609350
57MP0004087_abnormal_muscle_fiber1.26322693
58MP0003879_abnormal_hair_cell1.23074174
59MP0003633_abnormal_nervous_system1.22596468
60MP0001984_abnormal_olfaction1.21828718
61MP0000003_abnormal_adipose_tissue1.20532522
62MP0002184_abnormal_innervation1.19911532
63MP0003075_altered_response_to1.18063779
64MP0000343_altered_response_to1.16989826
65MP0008874_decreased_physiological_sensi1.16140786
66MP0002066_abnormal_motor_capabilities/c1.15581105
67MP0008775_abnormal_heart_ventricle1.15273379
68MP0005334_abnormal_fat_pad1.09813137
69MP0008961_abnormal_basal_metabolism1.09293875
70MP0001905_abnormal_dopamine_level1.09073429
71MP0005165_increased_susceptibility_to1.08694270
72MP0000955_abnormal_spinal_cord1.07918358
73MP0005385_cardiovascular_system_phenoty1.07104377
74MP0001544_abnormal_cardiovascular_syste1.07104377
75MP0002127_abnormal_cardiovascular_syste1.06783876
76MP0000013_abnormal_adipose_tissue1.03268600
77MP0002882_abnormal_neuron_morphology1.03002478
78MP0006138_congestive_heart_failure1.02036014
79MP0004233_abnormal_muscle_weight1.01348868
80MP0004145_abnormal_muscle_electrophysio0.99927343
81MP0000747_muscle_weakness0.98401766
82MP0006276_abnormal_autonomic_nervous0.98337048
83MP0005167_abnormal_blood-brain_barrier0.97304978
84MP0002269_muscular_atrophy0.96725568
85MP0000778_abnormal_nervous_system0.95699785
86MP0002876_abnormal_thyroid_physiology0.95323367
87MP0010329_abnormal_lipoprotein_level0.94848696
88MP0002106_abnormal_muscle_physiology0.94593383
89MP0005535_abnormal_body_temperature0.94258879
90MP0003631_nervous_system_phenotype0.91665554
91MP0003959_abnormal_lean_body0.91390739
92MP0004885_abnormal_endolymph0.91024091
93MP0005409_darkened_coat_color0.90924839
94MP0005448_abnormal_energy_balance0.90578398
95MP0002970_abnormal_white_adipose0.87587127
96MP0002295_abnormal_pulmonary_circulatio0.85007328
97MP0008872_abnormal_physiological_respon0.84511659
98MP0000759_abnormal_skeletal_muscle0.82058542
99MP0001502_abnormal_circadian_rhythm0.81975523
100MP0002118_abnormal_lipid_homeostasis0.81160915
101MP0005503_abnormal_tendon_morphology0.79875966
102MP0005369_muscle_phenotype0.78558132
103MP0010630_abnormal_cardiac_muscle0.78553283
104MP0002108_abnormal_muscle_morphology0.78187511
105MP0010368_abnormal_lymphatic_system0.77920693
106MP0004142_abnormal_muscle_tone0.77332398
107MP0005452_abnormal_adipose_tissue0.77278185
108MP0002069_abnormal_eating/drinking_beha0.73691195
109MP0002078_abnormal_glucose_homeostasis0.72270997
110MP0002152_abnormal_brain_morphology0.70307814
111MP0002229_neurodegeneration0.69783569
112MP0005595_abnormal_vascular_smooth0.69572148
113MP0002234_abnormal_pharynx_morphology0.69017198
114MP0003283_abnormal_digestive_organ0.68150148
115MP0004043_abnormal_pH_regulation0.67477380
116MP0002090_abnormal_vision0.66703243
117MP0000750_abnormal_muscle_regeneration0.65957367
118MP0000230_abnormal_systemic_arterial0.65605781
119MP0001177_atelectasis0.65345609
120MP0000920_abnormal_myelination0.64481950
121MP0003787_abnormal_imprinting0.63295529
122MP0003690_abnormal_glial_cell0.62761851
123MP0003634_abnormal_glial_cell0.61952412
124MP0006036_abnormal_mitochondrial_physio0.61000213
125MP0010234_abnormal_vibrissa_follicle0.58767894
126MP0005623_abnormal_meninges_morphology0.58227375

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.35331873
2Focal motor seizures (HP:0011153)6.43932653
3Sudden death (HP:0001699)5.10682727
4Focal seizures (HP:0007359)4.80834329
5Bundle branch block (HP:0011710)4.35829451
6Atrial fibrillation (HP:0005110)4.27336883
7Primary atrial arrhythmia (HP:0001692)4.16752623
8Ventricular fibrillation (HP:0001663)4.12667941
9Prolonged QT interval (HP:0001657)3.99574094
10Supraventricular tachycardia (HP:0004755)3.98301190
11Supraventricular arrhythmia (HP:0005115)3.87064906
12Visual hallucinations (HP:0002367)3.84340245
13Oligomenorrhea (HP:0000876)3.72103928
14Syncope (HP:0001279)3.67985938
15Heart block (HP:0012722)3.55251929
16Exercise-induced myalgia (HP:0003738)3.54895895
17Abnormal EKG (HP:0003115)3.50397368
18Atrioventricular block (HP:0001678)3.47691021
19Action tremor (HP:0002345)3.43769197
20Calf muscle hypertrophy (HP:0008981)3.31990771
21Epileptic encephalopathy (HP:0200134)3.31796400
22Poor eye contact (HP:0000817)3.30490247
23Abnormal atrioventricular conduction (HP:0005150)3.27242269
24Febrile seizures (HP:0002373)3.24577020
25Atonic seizures (HP:0010819)3.19860540
26Anxiety (HP:0000739)3.16846808
27Annular pancreas (HP:0001734)3.14758383
28Depression (HP:0000716)3.10845555
29Impaired vibration sensation in the lower limbs (HP:0002166)3.09316594
30Generalized tonic-clonic seizures (HP:0002069)3.07827343
31Absence seizures (HP:0002121)3.07063262
32Abnormal social behavior (HP:0012433)3.06192883
33Impaired social interactions (HP:0000735)3.06192883
34Dysmetric saccades (HP:0000641)3.01403671
35Ankle clonus (HP:0011448)3.00207069
36Resting tremor (HP:0002322)2.99705486
37Ventricular tachycardia (HP:0004756)2.98845214
38Ventricular arrhythmia (HP:0004308)2.97606602
39Muscle hypertrophy of the lower extremities (HP:0008968)2.97262804
40Torticollis (HP:0000473)2.91525725
41EMG: neuropathic changes (HP:0003445)2.91287926
42Dialeptic seizures (HP:0011146)2.87435993
43Abnormality of the calf musculature (HP:0001430)2.87117145
44Dysdiadochokinesis (HP:0002075)2.83897830
45Exercise-induced muscle cramps (HP:0003710)2.73544144
46Progressive cerebellar ataxia (HP:0002073)2.73488429
47Pheochromocytoma (HP:0002666)2.72964131
48Abnormality of skeletal muscle fiber size (HP:0012084)2.72428278
49Distal lower limb muscle weakness (HP:0009053)2.72420016
50Urinary bladder sphincter dysfunction (HP:0002839)2.70559088
51Postural instability (HP:0002172)2.69078087
52Urinary urgency (HP:0000012)2.66617410
53Lower limb amyotrophy (HP:0007210)2.66146501
54Broad-based gait (HP:0002136)2.65415597
55Acanthosis nigricans (HP:0000956)2.64330441
56Dysmetria (HP:0001310)2.61904812
57Gaze-evoked nystagmus (HP:0000640)2.61495943
58Focal dystonia (HP:0004373)2.58588774
59Myotonia (HP:0002486)2.55150047
60Frequent falls (HP:0002359)2.53442020
61Diplopia (HP:0000651)2.53289990
62Abnormality of binocular vision (HP:0011514)2.53289990
63Palpitations (HP:0001962)2.53228560
64Increased connective tissue (HP:0009025)2.52147844
65Mutism (HP:0002300)2.46976446
66Abnormality of the lower motor neuron (HP:0002366)2.41577426
67Craniofacial dystonia (HP:0012179)2.41071401
68Hyporeflexia of lower limbs (HP:0002600)2.39530910
69Hemiplegia (HP:0002301)2.38782979
70Hypertriglyceridemia (HP:0002155)2.38520957
71Neck muscle weakness (HP:0000467)2.38317706
72Neuroendocrine neoplasm (HP:0100634)2.36923435
73Supranuclear gaze palsy (HP:0000605)2.34707254
74Distal lower limb amyotrophy (HP:0008944)2.32519519
75Obstructive sleep apnea (HP:0002870)2.32317716
76Ragged-red muscle fibers (HP:0003200)2.29661207
77Truncal ataxia (HP:0002078)2.29519579
78Myoglobinuria (HP:0002913)2.28502811
79Sudden cardiac death (HP:0001645)2.24360842
80Amblyopia (HP:0000646)2.22870876
81Skin nodule (HP:0200036)2.22558027
82Muscle fiber splitting (HP:0003555)2.21801779
83Neurofibrillary tangles (HP:0002185)2.20503157
84Termporal pattern (HP:0011008)2.20295907
85Insidious onset (HP:0003587)2.20295907
86Bradycardia (HP:0001662)2.20084051
87Abnormal eating behavior (HP:0100738)2.16997039
88Left ventricular hypertrophy (HP:0001712)2.15680317
89Rapidly progressive (HP:0003678)2.15020300
90Abnormality of pain sensation (HP:0010832)2.14692776
91Impaired pain sensation (HP:0007328)2.14692776
92Pointed chin (HP:0000307)2.14431504
93Hypercortisolism (HP:0001578)2.13588556
94Subaortic stenosis (HP:0001682)2.13376730
95Abnormality of the left ventricular outflow tract (HP:0011103)2.13376730
96EMG: myopathic abnormalities (HP:0003458)2.13158657
97Tetraplegia (HP:0002445)2.12446657
98Increased serum pyruvate (HP:0003542)2.12373682
99Steppage gait (HP:0003376)2.12084378
100Lipoatrophy (HP:0100578)2.11397842
101Abnormality of glycolysis (HP:0004366)2.09627995
102Stereotypic behavior (HP:0000733)2.09098608
103Progressive inability to walk (HP:0002505)2.09020947
104Papilledema (HP:0001085)2.07965968
105Bradykinesia (HP:0002067)2.06310432
106Difficulty running (HP:0009046)2.05916815
107Impaired vibratory sensation (HP:0002495)2.04224480
108Neoplasm of the peripheral nervous system (HP:0100007)2.03812871
109Right ventricular cardiomyopathy (HP:0011663)2.02280772
110Cerebral inclusion bodies (HP:0100314)2.01888242
111Scanning speech (HP:0002168)2.01229741
112Hyperventilation (HP:0002883)2.00956475
113Spastic gait (HP:0002064)1.97901642
114Dilated cardiomyopathy (HP:0001644)1.96270370
115Athetosis (HP:0002305)1.94106092
116Scapular winging (HP:0003691)1.92500562
117Polyphagia (HP:0002591)1.92399222
118Asymmetric septal hypertrophy (HP:0001670)1.91965151
119Lower limb asymmetry (HP:0100559)1.91817767
120Axonal loss (HP:0003447)1.91416160
121Testicular atrophy (HP:0000029)1.90404330
122Rimmed vacuoles (HP:0003805)1.89988717
123Foot dorsiflexor weakness (HP:0009027)1.89799129
124Increased variability in muscle fiber diameter (HP:0003557)1.89631653
125Lower limb muscle weakness (HP:0007340)1.88705625
126Incomplete penetrance (HP:0003829)1.88353998
127Intention tremor (HP:0002080)1.86571976
128Abnormality of the foot musculature (HP:0001436)1.86186892
129Slow progression (HP:0003677)1.84340946
130Increased muscle lipid content (HP:0009058)1.83524954
131Megalencephaly (HP:0001355)1.83256161
132Insulin-resistant diabetes mellitus (HP:0000831)1.82621248
133Central scotoma (HP:0000603)1.81941136
134Hyperlipoproteinemia (HP:0010980)1.76707346
135Rhabdomyolysis (HP:0003201)1.76435936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.01825486
2NTRK33.97434414
3MAP3K93.46539025
4KSR22.81921923
5PRKD32.69305593
6DAPK22.64024813
7LMTK22.32129728
8RIPK42.16169512
9MINK12.13239603
10MAP3K42.10232728
11PAK61.95218382
12ARAF1.91303047
13CAMKK11.88229590
14PHKG21.82330229
15PHKG11.82330229
16PINK11.69106675
17MAP3K131.58324010
18NEK11.58293376
19NTRK11.57968474
20TIE11.55121877
21KSR11.54428652
22DAPK11.46733475
23STK381.45594863
24CDK51.43352742
25MAP2K71.40200326
26MARK11.39106751
27NTRK21.36446133
28FES1.35454096
29TAOK11.31749057
30MAP3K21.30568416
31DMPK1.30304318
32OBSCN1.28136317
33MAP2K41.27775078
34PDK41.26442239
35PDK31.26442239
36PRPF4B1.19809512
37MAP3K61.15237649
38TTN1.15173221
39GRK51.12984529
40PTK2B1.12090534
41PRKAA21.11788074
42PKN11.09286354
43MAP3K121.08681010
44MAPK41.08460559
45TYRO31.06912283
46RAF11.06802645
47TNIK1.06617872
48SIK21.05078502
49TESK11.02201058
50CAMK2A1.01967662
51TRIB31.01148960
52CAMK11.00415816
53DDR20.96847692
54CASK0.96323574
55PRKCH0.95545137
56PAK30.95359206
57SGK2230.93378353
58SGK4940.93378353
59CAMKK20.93046098
60MUSK0.89652547
61RET0.89304428
62PDK10.88840012
63PRKCG0.88706235
64PRKAA10.87296164
65PDPK10.86836358
66MAP3K10.86810581
67SGK20.85566948
68SGK30.84782838
69MYLK0.83109334
70CAMK2D0.82854497
71ROCK20.79956163
72EPHB20.79689778
73UHMK10.78400835
74NEK90.75794704
75MAP3K50.74518471
76CAMK2B0.74219220
77DAPK30.73150463
78PKN20.72193432
79STK110.72153415
80SGK10.71073162
81CAMK40.70879664
82PRKG10.70266582
83TGFBR20.68334662
84PLK20.67091353
85MARK20.66401864
86CDK140.66199185
87CDK180.65958135
88CDK150.64520264
89MAP3K70.63962716
90CDC42BPA0.63854171
91MAPK100.62306638
92MAPKAPK30.61822508
93MAP2K10.60602205
94ALK0.58249303
95CAMK1D0.57202231
96MAPK130.56727980
97PDK20.56609455
98RIPK10.55239244
99DYRK1A0.54389736
100CDK11A0.54313848
101PRKD10.54111034
102PRKCE0.52767916
103BMPR20.51124248
104LATS20.50884238
105RPS6KA30.50463387
106CAMK1G0.48678662
107CAMK2G0.48624107
108STK38L0.46964419
109PIK3CA0.46648267
110WNK10.43607991
111LIMK10.42008522
112ROCK10.40759078
113FYN0.40527740
114PRKCZ0.39882628
115MAPK120.39335115
116PDGFRA0.39012493
117GRK70.38873086
118TNK20.37380569
119CDK190.37237995
120PRKACG0.36979324
121PRKACA0.36906676
122RPS6KA20.36826929
123FER0.36516436
124BRAF0.36388552

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.04297368
2Nicotine addiction_Homo sapiens_hsa050332.60925747
3Synaptic vesicle cycle_Homo sapiens_hsa047212.59365690
4Circadian entrainment_Homo sapiens_hsa047132.57714647
5Long-term potentiation_Homo sapiens_hsa047202.46808673
6Morphine addiction_Homo sapiens_hsa050322.37850154
7PPAR signaling pathway_Homo sapiens_hsa033202.35441397
8Amphetamine addiction_Homo sapiens_hsa050312.35260880
9GABAergic synapse_Homo sapiens_hsa047272.31752170
10Glutamatergic synapse_Homo sapiens_hsa047242.25479748
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20831771
12Cardiac muscle contraction_Homo sapiens_hsa042602.12348428
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.09155718
14Dopaminergic synapse_Homo sapiens_hsa047282.06309680
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02395611
16Salivary secretion_Homo sapiens_hsa049701.93256117
17Cholinergic synapse_Homo sapiens_hsa047251.91492169
18Insulin secretion_Homo sapiens_hsa049111.90593204
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88779030
20Phenylalanine metabolism_Homo sapiens_hsa003601.80675611
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79691104
22Gastric acid secretion_Homo sapiens_hsa049711.78535916
23Cocaine addiction_Homo sapiens_hsa050301.77396372
24Calcium signaling pathway_Homo sapiens_hsa040201.76092852
25Oxytocin signaling pathway_Homo sapiens_hsa049211.71372394
26Dilated cardiomyopathy_Homo sapiens_hsa054141.71036909
27Renin secretion_Homo sapiens_hsa049241.70806247
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64355992
29Taste transduction_Homo sapiens_hsa047421.45959062
30GnRH signaling pathway_Homo sapiens_hsa049121.38313413
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36120584
32Fatty acid biosynthesis_Homo sapiens_hsa000611.35344998
33Pyruvate metabolism_Homo sapiens_hsa006201.35330863
34cAMP signaling pathway_Homo sapiens_hsa040241.32909188
35Gap junction_Homo sapiens_hsa045401.32808078
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29472448
37Serotonergic synapse_Homo sapiens_hsa047261.27821359
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26185162
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26054320
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24054828
41Fatty acid degradation_Homo sapiens_hsa000711.23938687
42Long-term depression_Homo sapiens_hsa047301.22344568
43Nitrogen metabolism_Homo sapiens_hsa009101.20687214
44Glycerolipid metabolism_Homo sapiens_hsa005611.20400506
45Type II diabetes mellitus_Homo sapiens_hsa049301.19553354
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18767725
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16571906
48Fatty acid metabolism_Homo sapiens_hsa012121.13312265
49Parkinsons disease_Homo sapiens_hsa050121.12791312
50beta-Alanine metabolism_Homo sapiens_hsa004101.12688770
51AMPK signaling pathway_Homo sapiens_hsa041521.11545553
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09856583
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.05832521
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04996748
55Glioma_Homo sapiens_hsa052141.03251381
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00940696
57Collecting duct acid secretion_Homo sapiens_hsa049660.99555474
58Estrogen signaling pathway_Homo sapiens_hsa049150.96795967
59Histidine metabolism_Homo sapiens_hsa003400.94893904
60Alzheimers disease_Homo sapiens_hsa050100.94325224
61Melanogenesis_Homo sapiens_hsa049160.87220239
62Ovarian steroidogenesis_Homo sapiens_hsa049130.86632499
63Fatty acid elongation_Homo sapiens_hsa000620.85398563
64Oxidative phosphorylation_Homo sapiens_hsa001900.84228400
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83741599
66Pancreatic secretion_Homo sapiens_hsa049720.83298846
67Arginine and proline metabolism_Homo sapiens_hsa003300.80989011
68Dorso-ventral axis formation_Homo sapiens_hsa043200.80538707
69Glucagon signaling pathway_Homo sapiens_hsa049220.79143803
70ErbB signaling pathway_Homo sapiens_hsa040120.76886014
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75227339
72VEGF signaling pathway_Homo sapiens_hsa043700.75021029
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74779209
74Vitamin B6 metabolism_Homo sapiens_hsa007500.74137819
75Tyrosine metabolism_Homo sapiens_hsa003500.73001509
76Oocyte meiosis_Homo sapiens_hsa041140.72458102
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70878325
78Axon guidance_Homo sapiens_hsa043600.67296686
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65003922
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64666727
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64103583
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63828189
83Rap1 signaling pathway_Homo sapiens_hsa040150.62099663
84Thyroid hormone synthesis_Homo sapiens_hsa049180.61048323
85Insulin signaling pathway_Homo sapiens_hsa049100.59980246
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.58570159
87Choline metabolism in cancer_Homo sapiens_hsa052310.58084979
88Non-small cell lung cancer_Homo sapiens_hsa052230.57989807
89MAPK signaling pathway_Homo sapiens_hsa040100.57569180
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57258879
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.54021417
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52181049
93mTOR signaling pathway_Homo sapiens_hsa041500.52063902
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51912002
95Vibrio cholerae infection_Homo sapiens_hsa051100.51494179
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51244341
97Focal adhesion_Homo sapiens_hsa045100.50879675
98Huntingtons disease_Homo sapiens_hsa050160.49765451
99Tryptophan metabolism_Homo sapiens_hsa003800.49215525
100Butanoate metabolism_Homo sapiens_hsa006500.48569759
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48296254
102Bile secretion_Homo sapiens_hsa049760.47978723
103Arginine biosynthesis_Homo sapiens_hsa002200.46483481
104Propanoate metabolism_Homo sapiens_hsa006400.46118558
105Phototransduction_Homo sapiens_hsa047440.45502500
106Ras signaling pathway_Homo sapiens_hsa040140.45193486
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44852903
108ECM-receptor interaction_Homo sapiens_hsa045120.42246603
109Carbon metabolism_Homo sapiens_hsa012000.41974737
110Endocytosis_Homo sapiens_hsa041440.40500608
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.39721955
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39343924
113Alcoholism_Homo sapiens_hsa050340.39030207
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.38156276
115Circadian rhythm_Homo sapiens_hsa047100.37880890
116Inositol phosphate metabolism_Homo sapiens_hsa005620.37576676
117Type I diabetes mellitus_Homo sapiens_hsa049400.34855778
118Endometrial cancer_Homo sapiens_hsa052130.33188427
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.32914142
120Renal cell carcinoma_Homo sapiens_hsa052110.32704424
121HIF-1 signaling pathway_Homo sapiens_hsa040660.32594443
122Prion diseases_Homo sapiens_hsa050200.31803504
123Insulin resistance_Homo sapiens_hsa049310.29285441

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