KCNIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.56971395
2glutamate secretion (GO:0014047)5.82568532
3synaptic vesicle exocytosis (GO:0016079)5.82319190
4locomotory exploration behavior (GO:0035641)5.77887611
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.63929011
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.62669905
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.59408014
8neurotransmitter-gated ion channel clustering (GO:0072578)5.38604028
9vocalization behavior (GO:0071625)5.30022743
10regulation of synaptic vesicle exocytosis (GO:2000300)5.20194750
11synaptic vesicle maturation (GO:0016188)5.19926334
12neuron cell-cell adhesion (GO:0007158)5.09620791
13protein localization to synapse (GO:0035418)4.89582358
14regulation of glutamate receptor signaling pathway (GO:1900449)4.88057618
15neuronal action potential propagation (GO:0019227)4.84563240
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.62841743
17regulation of synaptic vesicle transport (GO:1902803)4.56879357
18presynaptic membrane assembly (GO:0097105)4.49736024
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.39777120
20postsynaptic membrane organization (GO:0001941)4.37493509
21synaptic transmission, glutamatergic (GO:0035249)4.37482128
22neurotransmitter secretion (GO:0007269)4.34806347
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29002498
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.27727184
25exploration behavior (GO:0035640)4.27332237
26presynaptic membrane organization (GO:0097090)4.17832783
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.15895359
28positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.13803889
29cerebellar granule cell differentiation (GO:0021707)4.09955756
30neuron-neuron synaptic transmission (GO:0007270)4.08431737
31regulation of neuronal synaptic plasticity (GO:0048168)4.08172154
32long-term synaptic potentiation (GO:0060291)4.07105023
33glutamate receptor signaling pathway (GO:0007215)4.04709268
34cellular potassium ion homeostasis (GO:0030007)4.01599867
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96564636
36positive regulation of neurotransmitter secretion (GO:0001956)3.93273484
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.92902063
38regulation of synaptic transmission, glutamatergic (GO:0051966)3.90468393
39proline transport (GO:0015824)3.89618182
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.88673596
41regulation of synapse structural plasticity (GO:0051823)3.87445724
42neuronal ion channel clustering (GO:0045161)3.81438064
43potassium ion homeostasis (GO:0055075)3.76783775
44mechanosensory behavior (GO:0007638)3.76576598
45auditory behavior (GO:0031223)3.74821179
46positive regulation of membrane potential (GO:0045838)3.74128426
47regulation of neurotransmitter secretion (GO:0046928)3.73392968
48gamma-aminobutyric acid transport (GO:0015812)3.72887760
49regulation of postsynaptic membrane potential (GO:0060078)3.71695872
50regulation of synaptic plasticity (GO:0048167)3.69108513
51cytoskeletal anchoring at plasma membrane (GO:0007016)3.66416565
52positive regulation of dendritic spine development (GO:0060999)3.65716371
53response to auditory stimulus (GO:0010996)3.63067598
54central nervous system myelination (GO:0022010)3.59361038
55axon ensheathment in central nervous system (GO:0032291)3.59361038
56positive regulation of neurotransmitter transport (GO:0051590)3.57966732
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57959047
58positive regulation of synapse maturation (GO:0090129)3.56501998
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.55783398
60negative regulation of dendrite morphogenesis (GO:0050774)3.53995013
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53181189
62regulation of ARF protein signal transduction (GO:0032012)3.51998896
63potassium ion import (GO:0010107)3.50926552
64sodium ion export (GO:0071436)3.49446108
65neurotransmitter transport (GO:0006836)3.49439547
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45280110
67long-term memory (GO:0007616)3.43247868
68innervation (GO:0060384)3.42059444
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42033422
70response to histamine (GO:0034776)3.41181298
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40825528
72regulation of neurotransmitter transport (GO:0051588)3.39257740
73negative regulation of dendrite development (GO:2000171)3.37273722
74cerebellar Purkinje cell differentiation (GO:0021702)3.37109441
75positive regulation of synaptic transmission (GO:0050806)3.34761282
76L-amino acid import (GO:0043092)3.33157124
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.31886454
78regulation of voltage-gated calcium channel activity (GO:1901385)3.30053816
79membrane depolarization during action potential (GO:0086010)3.25440343
80regulation of neurotransmitter levels (GO:0001505)3.25149588
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24606615
82membrane depolarization (GO:0051899)3.24444018
83dendritic spine morphogenesis (GO:0060997)3.22420958
84cell communication by electrical coupling (GO:0010644)3.22157782
85neuromuscular process controlling balance (GO:0050885)3.15967499
86synaptic vesicle endocytosis (GO:0048488)3.15937750
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15177522
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13148110
89dendritic spine organization (GO:0097061)3.13018148
90cerebellar Purkinje cell layer development (GO:0021680)3.12621992
91regulation of synaptic transmission (GO:0050804)3.09889665
92cellular sodium ion homeostasis (GO:0006883)3.08125030
93membrane hyperpolarization (GO:0060081)3.07546884
94activation of protein kinase A activity (GO:0034199)3.05718392
95acidic amino acid transport (GO:0015800)3.04222219
96layer formation in cerebral cortex (GO:0021819)3.03351770
97startle response (GO:0001964)3.00688408
98regulation of respiratory system process (GO:0044065)3.00572446
99synapse assembly (GO:0007416)2.98746635
100transmission of nerve impulse (GO:0019226)2.98415254
101regulation of dendritic spine development (GO:0060998)2.98259931
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.97780160
103learning (GO:0007612)2.96761114
104synaptic transmission (GO:0007268)2.96081329
105neuromuscular process (GO:0050905)2.93631537
106regulation of synapse maturation (GO:0090128)2.93274594
107response to gravity (GO:0009629)2.92709687
108neurotransmitter uptake (GO:0001504)2.91458443
109regulation of vesicle fusion (GO:0031338)2.90333729
110regulation of dendritic spine morphogenesis (GO:0061001)2.89765149
111calcium ion-dependent exocytosis (GO:0017156)2.89742687
112positive regulation of synapse assembly (GO:0051965)2.88714791
113positive regulation of dendrite development (GO:1900006)2.85366991
114neuron recognition (GO:0008038)2.84979267
115regulation of glutamate secretion (GO:0014048)2.84949827
116regulation of female receptivity (GO:0045924)2.83112449
117vesicle docking involved in exocytosis (GO:0006904)2.82956788
118amino acid import (GO:0043090)2.82448917
119negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.82377761
120prepulse inhibition (GO:0060134)2.81188481
121dicarboxylic acid transport (GO:0006835)2.77325754
122phosphorelay signal transduction system (GO:0000160)2.66013953
123L-glutamate transport (GO:0015813)2.64881522
124cochlea development (GO:0090102)2.59613680
125neuromuscular synaptic transmission (GO:0007274)2.59464582
126regulation of dendrite morphogenesis (GO:0048814)2.59047073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.33660576
2GBX2_23144817_ChIP-Seq_PC3_Human4.19032558
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.30033837
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.22194781
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09495783
6* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.08006511
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81308531
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81308531
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74149183
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.73884725
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71173079
12REST_21632747_ChIP-Seq_MESCs_Mouse2.70110114
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60275741
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.53198787
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.52844947
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52243120
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48387867
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.43417913
19DROSHA_22980978_ChIP-Seq_HELA_Human2.38292336
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.25318335
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.19545903
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18532033
23AR_21572438_ChIP-Seq_LNCaP_Human2.16647582
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14611719
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.13589939
26TAF15_26573619_Chip-Seq_HEK293_Human2.02699568
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01108503
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00856030
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98606246
30KDM2B_26808549_Chip-Seq_K562_Human1.97538646
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95965695
32LXR_22292898_ChIP-Seq_THP-1_Human1.93919972
33* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93177412
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91603894
35SMAD4_21799915_ChIP-Seq_A2780_Human1.79609021
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78619868
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77228646
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76629929
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74674417
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73519513
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72420968
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.71485440
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.70368035
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68791055
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67631076
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59506238
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58326051
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57770535
49P300_19829295_ChIP-Seq_ESCs_Human1.57072544
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56633585
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55541278
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55129358
53* TET1_21490601_ChIP-Seq_MESCs_Mouse1.54864774
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.54590546
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.53079037
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52343557
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50465485
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47602486
59* CTCF_27219007_Chip-Seq_Bcells_Human1.46807158
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45459560
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44192004
62* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43084401
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41366279
64AR_25329375_ChIP-Seq_VCAP_Human1.39565544
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.38161378
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.37959132
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.34019073
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33741890
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.32567887
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30539560
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29300264
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28933740
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26823230
74* STAT3_23295773_ChIP-Seq_U87_Human1.26176500
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25501652
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.23097587
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22938113
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22694171
79AR_19668381_ChIP-Seq_PC3_Human1.21145411
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.19930917
81SMC4_20622854_ChIP-Seq_HELA_Human1.19256088
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18497777
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18409139
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17701253
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17343648
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16983009
87TCF4_23295773_ChIP-Seq_U87_Human1.16940900
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15209018
89TP53_23651856_ChIP-Seq_MEFs_Mouse1.14554150
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14316209
91RXR_22108803_ChIP-Seq_LS180_Human1.13767400
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.11364343
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10225438
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10032551
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09439281
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09413555
97* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08454562
98RNF2_27304074_Chip-Seq_NSC_Mouse1.07131585
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.05794682
100CREB1_26743006_Chip-Seq_LNCaP_Human1.05630253
101ZNF274_21170338_ChIP-Seq_K562_Hela1.04695670
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04517628
103P68_20966046_ChIP-Seq_HELA_Human1.03652062
104* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03075522
105SMAD3_21741376_ChIP-Seq_ESCs_Human1.02670145
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01517639
107AHR_22903824_ChIP-Seq_MCF-7_Human1.01250141
108KDM2B_26808549_Chip-Seq_DND41_Human1.01006774
109RACK7_27058665_Chip-Seq_MCF-7_Human1.00858943
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.00664710
111RUNX2_22187159_ChIP-Seq_PCA_Human0.98678119
112FUS_26573619_Chip-Seq_HEK293_Human0.98522183
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98344664
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98239494
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98172927
116BCAT_22108803_ChIP-Seq_LS180_Human0.97533159
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.97441510
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97397114
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.96595065
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95881638
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94817389
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94669836
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94544650
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.93257360
125TP53_18474530_ChIP-ChIP_U2OS_Human0.93162209
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93005694
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92876001
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92266290
129* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92263969
130* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91785306
131SOX9_26525672_Chip-Seq_HEART_Mouse0.91716806
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.91654990
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91556757
134* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91535362
135OCT4_19829295_ChIP-Seq_ESCs_Human0.91155920
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90730059
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90730059
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.89851051
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89476126
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89449394
141TP53_16413492_ChIP-PET_HCT116_Human0.89264971
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87719619
143JUN_21703547_ChIP-Seq_K562_Human0.87033081
144MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86339421
145KLF4_19829295_ChIP-Seq_ESCs_Human0.83277951
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.82197957
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82156946
148CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80415478
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.79827291
150TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79023029
151* MITF_21258399_ChIP-Seq_MELANOMA_Human0.78721178
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78013090
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77972483
154GATA1_26923725_Chip-Seq_HPCs_Mouse0.77922884
155MYC_19915707_ChIP-ChIP_AK7_Human0.77714947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.95597215
2MP0003880_abnormal_central_pattern5.08195990
3* MP0003635_abnormal_synaptic_transmissio4.02730737
4MP0004270_analgesia3.77768478
5* MP0001968_abnormal_touch/_nociception3.49386460
6MP0009745_abnormal_behavioral_response3.45045204
7MP0009046_muscle_twitch3.33289664
8MP0002064_seizures3.27873639
9* MP0002063_abnormal_learning/memory/cond3.24736010
10* MP0002736_abnormal_nociception_after2.88131047
11* MP0002572_abnormal_emotion/affect_behav2.85319353
12MP0009780_abnormal_chondrocyte_physiolo2.71346622
13MP0001486_abnormal_startle_reflex2.71140061
14MP0003705_abnormal_hypodermis_morpholog2.68175280
15MP0002272_abnormal_nervous_system2.67825491
16* MP0002734_abnormal_mechanical_nocicepti2.64659387
17MP0004858_abnormal_nervous_system2.52286599
18MP0005423_abnormal_somatic_nervous2.51049320
19* MP0002735_abnormal_chemical_nociception2.47024722
20MP0005646_abnormal_pituitary_gland2.45919191
21* MP0002067_abnormal_sensory_capabilities2.26515106
22MP0002822_catalepsy2.17729553
23MP0008569_lethality_at_weaning2.13895149
24MP0001440_abnormal_grooming_behavior2.13427473
25* MP0002733_abnormal_thermal_nociception2.09410389
26* MP0001970_abnormal_pain_threshold2.06714262
27MP0003879_abnormal_hair_cell2.05427289
28MP0001501_abnormal_sleep_pattern1.99112303
29MP0002557_abnormal_social/conspecific_i1.78266650
30MP0001984_abnormal_olfaction1.74186124
31MP0005386_behavior/neurological_phenoty1.69394336
32MP0004924_abnormal_behavior1.69394336
33MP0004811_abnormal_neuron_physiology1.67300962
34MP0002184_abnormal_innervation1.66230667
35MP0000778_abnormal_nervous_system1.65433556
36MP0005623_abnormal_meninges_morphology1.60111701
37MP0003329_amyloid_beta_deposits1.59422917
38MP0006276_abnormal_autonomic_nervous1.59386159
39MP0001502_abnormal_circadian_rhythm1.55749388
40MP0003633_abnormal_nervous_system1.48757144
41MP0000955_abnormal_spinal_cord1.48628109
42MP0002909_abnormal_adrenal_gland1.46887972
43MP0005645_abnormal_hypothalamus_physiol1.43847068
44MP0004885_abnormal_endolymph1.42766152
45MP0002882_abnormal_neuron_morphology1.39191008
46* MP0002066_abnormal_motor_capabilities/c1.37963001
47MP0001188_hyperpigmentation1.34769701
48MP0001348_abnormal_lacrimal_gland1.27762553
49MP0004142_abnormal_muscle_tone1.27761330
50MP0001958_emphysema1.26645889
51MP0003787_abnormal_imprinting1.26224899
52MP0008438_abnormal_cutaneous_collagen1.25395783
53MP0003631_nervous_system_phenotype1.24009747
54MP0002876_abnormal_thyroid_physiology1.23311906
55MP0001905_abnormal_dopamine_level1.18118145
56MP0001529_abnormal_vocalization1.13901956
57MP0003690_abnormal_glial_cell1.13713180
58MP0004742_abnormal_vestibular_system1.08614334
59MP0001963_abnormal_hearing_physiology1.08503071
60MP0005670_abnormal_white_adipose1.05405246
61MP0002152_abnormal_brain_morphology1.03606032
62MP0005171_absent_coat_pigmentation1.03327507
63MP0000013_abnormal_adipose_tissue1.03180788
64MP0002229_neurodegeneration0.98479642
65MP0008874_decreased_physiological_sensi0.97600823
66MP0002249_abnormal_larynx_morphology0.97039238
67MP0003634_abnormal_glial_cell0.95651900
68MP0001485_abnormal_pinna_reflex0.94181313
69MP0001986_abnormal_taste_sensitivity0.93398409
70MP0003075_altered_response_to0.93260068
71MP0008872_abnormal_physiological_respon0.93186021
72MP0005551_abnormal_eye_electrophysiolog0.91061855
73MP0000579_abnormal_nail_morphology0.90016298
74MP0000534_abnormal_ureter_morphology0.89976419
75MP0002069_abnormal_eating/drinking_beha0.89270702
76MP0004130_abnormal_muscle_cell0.88178287
77MP0003283_abnormal_digestive_organ0.87549065
78MP0003632_abnormal_nervous_system0.85829325
79MP0000751_myopathy0.85620694
80MP0002653_abnormal_ependyma_morphology0.83263961
81MP0000003_abnormal_adipose_tissue0.80608384
82MP0003122_maternal_imprinting0.80595102
83MP0005503_abnormal_tendon_morphology0.80561224
84MP0008004_abnormal_stomach_pH0.80150099
85MP0004215_abnormal_myocardial_fiber0.80001890
86MP0000631_abnormal_neuroendocrine_gland0.78930272
87MP0002089_abnormal_postnatal_growth/wei0.78130326
88MP0001664_abnormal_digestion0.78130027
89MP0004085_abnormal_heartbeat0.77431863
90MP0000747_muscle_weakness0.76933912
91MP0000920_abnormal_myelination0.75604230
92MP0003123_paternal_imprinting0.74246709
93MP0002752_abnormal_somatic_nervous0.73516322
94MP0003279_aneurysm0.71274624
95MP0001177_atelectasis0.70357440
96MP0005535_abnormal_body_temperature0.69514819
97MP0004145_abnormal_muscle_electrophysio0.68145345
98MP0003045_fibrosis0.65312535
99MP0000678_abnormal_parathyroid_gland0.64290203
100MP0004484_altered_response_of0.63760998
101MP0000569_abnormal_digit_pigmentation0.63563658
102MP0002090_abnormal_vision0.63391560
103MP0001943_abnormal_respiration0.62929018
104MP0000026_abnormal_inner_ear0.62916977
105MP0005167_abnormal_blood-brain_barrier0.62255675
106MP0004043_abnormal_pH_regulation0.61947417
107MP0003172_abnormal_lysosome_physiology0.61428645
108MP0000604_amyloidosis0.61137855
109MP0001346_abnormal_lacrimal_gland0.60946161
110MP0002295_abnormal_pulmonary_circulatio0.59377591
111MP0002896_abnormal_bone_mineralization0.58842442
112MP0002638_abnormal_pupillary_reflex0.57689141
113MP0001299_abnormal_eye_distance/0.57523347
114MP0000681_abnormal_thyroid_gland0.54456607
115MP0003137_abnormal_impulse_conducting0.53427136
116MP0010769_abnormal_survival0.52325162
117MP0005394_taste/olfaction_phenotype0.51971984
118MP0005499_abnormal_olfactory_system0.51971984
119MP0005595_abnormal_vascular_smooth0.51437584
120MP0010770_preweaning_lethality0.50567863
121MP0002082_postnatal_lethality0.50567863
122MP0002751_abnormal_autonomic_nervous0.50439652
123MP0001849_ear_inflammation0.50144904
124MP0005409_darkened_coat_color0.49800031
125MP0003861_abnormal_nervous_system0.49445182
126MP0005257_abnormal_intraocular_pressure0.49328089
127MP0010768_mortality/aging0.48647207
128MP0010386_abnormal_urinary_bladder0.48573388

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.48435311
2Myokymia (HP:0002411)6.88403839
3Epileptic encephalopathy (HP:0200134)6.06234986
4Focal seizures (HP:0007359)5.66570188
5Atonic seizures (HP:0010819)5.17068752
6Febrile seizures (HP:0002373)5.03592424
7Visual hallucinations (HP:0002367)4.60105582
8Hyperventilation (HP:0002883)4.57971629
9Progressive cerebellar ataxia (HP:0002073)4.54980458
10Action tremor (HP:0002345)4.33433850
11Neurofibrillary tangles (HP:0002185)4.10738690
12Absence seizures (HP:0002121)4.05857468
13Generalized tonic-clonic seizures (HP:0002069)3.93989604
14Dialeptic seizures (HP:0011146)3.88922991
15Obstructive sleep apnea (HP:0002870)3.88281000
16Gaze-evoked nystagmus (HP:0000640)3.79118059
17Broad-based gait (HP:0002136)3.74435504
18Impaired vibration sensation in the lower limbs (HP:0002166)3.41465150
19Cerebral inclusion bodies (HP:0100314)3.40851387
20Insomnia (HP:0100785)3.29963188
21Dysdiadochokinesis (HP:0002075)3.24755116
22Truncal ataxia (HP:0002078)3.15438404
23Abnormal eating behavior (HP:0100738)3.14913638
24Poor eye contact (HP:0000817)3.13592313
25Depression (HP:0000716)3.10068708
26Ankle clonus (HP:0011448)3.06039965
27Urinary bladder sphincter dysfunction (HP:0002839)3.03890232
28Pheochromocytoma (HP:0002666)2.95155158
29Megalencephaly (HP:0001355)2.85877133
30Dysmetric saccades (HP:0000641)2.85194627
31Postural instability (HP:0002172)2.83844291
32Anxiety (HP:0000739)2.77830946
33Impaired smooth pursuit (HP:0007772)2.73860507
34Fetal akinesia sequence (HP:0001989)2.73844234
35Amblyopia (HP:0000646)2.72274045
36Abnormal social behavior (HP:0012433)2.70843429
37Impaired social interactions (HP:0000735)2.70843429
38Shallow orbits (HP:0000586)2.70054997
39Dysmetria (HP:0001310)2.69052947
40Supranuclear gaze palsy (HP:0000605)2.65186728
41Akinesia (HP:0002304)2.64069533
42Hemiplegia (HP:0002301)2.62051963
43Scanning speech (HP:0002168)2.60098384
44Cerebral hypomyelination (HP:0006808)2.58689164
45Epileptiform EEG discharges (HP:0011182)2.58011313
46Neuroendocrine neoplasm (HP:0100634)2.57059969
47Diplopia (HP:0000651)2.53815723
48Abnormality of binocular vision (HP:0011514)2.53815723
49Impaired vibratory sensation (HP:0002495)2.53262395
50Protrusio acetabuli (HP:0003179)2.53170234
51Clonus (HP:0002169)2.52642075
52Hemiparesis (HP:0001269)2.52539541
53Genetic anticipation (HP:0003743)2.49644162
54Aplasia involving bones of the extremities (HP:0009825)2.49468512
55Aplasia involving bones of the upper limbs (HP:0009823)2.49468512
56Aplasia of the phalanges of the hand (HP:0009802)2.49468512
57Neuronal loss in central nervous system (HP:0002529)2.48292145
58Tetraplegia (HP:0002445)2.48033295
59Hyperacusis (HP:0010780)2.46441318
60Bradykinesia (HP:0002067)2.45930651
61Delusions (HP:0000746)2.45526550
62Urinary urgency (HP:0000012)2.44742229
63Turricephaly (HP:0000262)2.44207831
64Abnormality of ocular smooth pursuit (HP:0000617)2.43514941
65Status epilepticus (HP:0002133)2.39026806
66Stereotypic behavior (HP:0000733)2.38998984
67Excessive salivation (HP:0003781)2.37865936
68Drooling (HP:0002307)2.37865936
69Spastic gait (HP:0002064)2.37336742
70Termporal pattern (HP:0011008)2.36646646
71Insidious onset (HP:0003587)2.36646646
72Lower limb amyotrophy (HP:0007210)2.35353418
73Blue irides (HP:0000635)2.34033837
74EEG with generalized epileptiform discharges (HP:0011198)2.30193132
75Torticollis (HP:0000473)2.27967879
76Distal upper limb amyotrophy (HP:0007149)2.27764300
77Upper limb amyotrophy (HP:0009129)2.27764300
78Absent speech (HP:0001344)2.26581637
79Abnormality of the lower motor neuron (HP:0002366)2.26267571
80Annular pancreas (HP:0001734)2.25263181
81Apathy (HP:0000741)2.24553529
82Neoplasm of the peripheral nervous system (HP:0100007)2.23025604
83Mild short stature (HP:0003502)2.21070812
84Spinal canal stenosis (HP:0003416)2.19819173
85Lower limb muscle weakness (HP:0007340)2.19648422
86Incomplete penetrance (HP:0003829)2.17653069
87Hypsarrhythmia (HP:0002521)2.17570032
88Focal dystonia (HP:0004373)2.17480423
89Mutism (HP:0002300)2.16876785
90Polyphagia (HP:0002591)2.13577811
91Inability to walk (HP:0002540)2.12956707
92Premature rupture of membranes (HP:0001788)2.12916013
93Heterochromia iridis (HP:0001100)2.11888285
94Resting tremor (HP:0002322)2.09438920
95Protruding tongue (HP:0010808)2.08239515
96Increased circulating renin level (HP:0000848)2.05185091
97Narrow nasal bridge (HP:0000446)2.02023372
98Failure to thrive in infancy (HP:0001531)1.99848411
99Gait ataxia (HP:0002066)1.99809105
100Rapidly progressive (HP:0003678)1.98223312
101Abnormal hair whorl (HP:0010721)1.97334227
102Diminished motivation (HP:0000745)1.96019502
103Cerebral aneurysm (HP:0004944)1.95752079
104Specific learning disability (HP:0001328)1.93522339
105Hand muscle atrophy (HP:0009130)1.93302265
106Hypoventilation (HP:0002791)1.91205911
107Craniofacial dystonia (HP:0012179)1.87576278
108Papilledema (HP:0001085)1.87273091
109Bladder diverticulum (HP:0000015)1.87183554
110Intention tremor (HP:0002080)1.86722609
111Bowel diverticulosis (HP:0005222)1.86435237
112Ulnar claw (HP:0001178)1.85679498
113Limb dystonia (HP:0002451)1.85481011
114Gait imbalance (HP:0002141)1.85133922
115Rigidity (HP:0002063)1.84237039
116Progressive inability to walk (HP:0002505)1.84209753
117Abnormality of the corticospinal tract (HP:0002492)1.83429740
118Vascular tortuosity (HP:0004948)1.83173226
119Ventricular fibrillation (HP:0001663)1.82879168
120Hammertoe (HP:0001765)1.81526241
121Hyperthyroidism (HP:0000836)1.79506551
122Postural tremor (HP:0002174)1.78739033
123Bronchomalacia (HP:0002780)1.77357943
124Poor suck (HP:0002033)1.76649229
125Split foot (HP:0001839)1.75239582
126Limb ataxia (HP:0002070)1.74399234
127Abnormality of saccadic eye movements (HP:0000570)1.73898901
128Distal sensory impairment (HP:0002936)1.73514272
129Broad metatarsal (HP:0001783)1.73362998
130Hyperparathyroidism (HP:0000843)1.72032709
131Wormian bones (HP:0002645)1.70533951
132Generalized myoclonic seizures (HP:0002123)1.70475022
133Bundle branch block (HP:0011710)1.69954972
134Peripheral hypomyelination (HP:0007182)1.69905859
135Overriding aorta (HP:0002623)1.68490062
136Clumsiness (HP:0002312)1.67600371
137Pointed chin (HP:0000307)1.67393338
138Mitral regurgitation (HP:0001653)1.67251069
139Ulnar bowing (HP:0003031)1.67203174
140Congenital primary aphakia (HP:0007707)1.67146066
141Sleep apnea (HP:0010535)1.66406996
142Dementia (HP:0000726)1.64400343
143Alacrima (HP:0000522)1.63417612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.45461829
2EPHA44.03749590
3NTRK33.92851892
4DAPK23.25220069
5CDK192.93406052
6MAP3K42.91643970
7MAP2K72.88849722
8MAP3K122.81238224
9MAP3K92.67947818
10MINK12.29451701
11DAPK12.20956216
12PRPF4B2.08039224
13MAP2K41.92150466
14PLK21.83126822
15RIPK11.82550750
16NTRK21.80585439
17TNIK1.73448188
18RIPK41.69544315
19CAMKK11.67203523
20KSR21.66229696
21PAK61.61712946
22CCNB11.59183208
23AKT31.58991937
24PRKD31.58742294
25TRIB31.55561515
26CAMKK21.49877020
27MAPK131.47469515
28SGK21.47260729
29OXSR11.39493451
30SIK31.36243319
31MARK11.35290222
32SGK4941.34721828
33SGK2231.34721828
34GRK51.34289251
35LMTK21.33607526
36NTRK11.32727321
37CDK51.32572412
38PDGFRA1.28572578
39TESK11.26507973
40PRKCG1.20916228
41KSR11.19952833
42ARAF1.18765023
43SGK31.08659363
44PTK2B1.04907103
45LIMK11.03230072
46ICK1.03113009
47PHKG21.01458756
48PHKG11.01458756
49BRSK10.97021911
50RET0.90007949
51CAMK2A0.87726395
52PTK20.86745196
53FES0.86433383
54MAP3K20.85224779
55STK380.84108623
56CDK180.83214357
57SIK20.78668060
58CAMK10.78120796
59CDK150.77367749
60MAP3K130.73280849
61TSSK60.72598068
62CDK140.72122776
63PKN10.70916552
64PINK10.70647817
65MAP3K110.70207701
66UHMK10.69188611
67ALK0.67617129
68BMPR20.66940444
69CDK11A0.66705812
70PDK10.63507323
71SGK10.63305562
72PRKCH0.63260949
73TYRO30.62834505
74BRAF0.61700072
75STK110.60437565
76PDPK10.59412298
77MUSK0.58860991
78ROCK10.58634979
79PAK20.57973752
80DAPK30.57883403
81CAMK2B0.56820121
82INSRR0.55988548
83TNK20.55088327
84NEK60.54852812
85TAOK10.54663586
86DDR20.54639534
87CAMK40.52897774
88PRKCE0.52355275
89MAPK70.50578765
90RAF10.50437679
91MAP3K10.50140737
92TTN0.48920865
93BMX0.46901937
94DYRK1A0.45550333
95CAMK1G0.44715676
96MAPK120.44636183
97ADRBK20.43901872
98MOS0.43875174
99PRKG20.43072743
100PRKD20.43039218
101FER0.41602623
102DMPK0.41449437
103SIK10.41185474
104RPS6KA30.39244787
105MAP3K30.39107034
106PRKD10.37941026
107PAK30.37351201
108CAMK2G0.37187393
109IRAK20.37059636
110FGR0.36759594
111SMG10.36740952
112CDC42BPA0.36039248
113CAMK1D0.34912972
114NEK10.34592434
115MAP2K10.33970052
116ABL20.33815757
117MARK20.30582606
118ROCK20.29875938
119RPS6KA20.29696648
120LATS20.29481734
121CSNK1G20.27565467
122CAMK2D0.27522387
123PRKCA0.26475187
124WNK10.26300657
125FYN0.26284862
126PRKCZ0.26108419
127CDK30.25810318
128PNCK0.25685783
129MAPK100.25650796
130MAP3K70.24573708

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.87860474
2Nicotine addiction_Homo sapiens_hsa050333.68914394
3Olfactory transduction_Homo sapiens_hsa047403.01487579
4Circadian entrainment_Homo sapiens_hsa047132.62057105
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59064839
6Long-term potentiation_Homo sapiens_hsa047202.58064143
7Glutamatergic synapse_Homo sapiens_hsa047242.54179583
8Morphine addiction_Homo sapiens_hsa050322.49269274
9Amphetamine addiction_Homo sapiens_hsa050312.46038588
10GABAergic synapse_Homo sapiens_hsa047272.41451641
11Salivary secretion_Homo sapiens_hsa049702.14001198
12Insulin secretion_Homo sapiens_hsa049112.12304130
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08769240
14Dopaminergic synapse_Homo sapiens_hsa047282.03889476
15Collecting duct acid secretion_Homo sapiens_hsa049662.00133552
16Gastric acid secretion_Homo sapiens_hsa049711.97657185
17Taste transduction_Homo sapiens_hsa047421.80094212
18Vitamin B6 metabolism_Homo sapiens_hsa007501.73707621
19Cholinergic synapse_Homo sapiens_hsa047251.69848604
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68121530
21Calcium signaling pathway_Homo sapiens_hsa040201.65603850
22Renin secretion_Homo sapiens_hsa049241.63378334
23Long-term depression_Homo sapiens_hsa047301.59484424
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58179660
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55574667
26Oxytocin signaling pathway_Homo sapiens_hsa049211.50842036
27Serotonergic synapse_Homo sapiens_hsa047261.48513623
28Cocaine addiction_Homo sapiens_hsa050301.48462662
29Nitrogen metabolism_Homo sapiens_hsa009101.41054640
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37260866
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35969224
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32601894
33GnRH signaling pathway_Homo sapiens_hsa049121.30457593
34cAMP signaling pathway_Homo sapiens_hsa040241.28979077
35Gap junction_Homo sapiens_hsa045401.24233666
36Vibrio cholerae infection_Homo sapiens_hsa051101.20846579
37Glioma_Homo sapiens_hsa052141.17470597
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15961503
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15862852
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15248468
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13577988
42ErbB signaling pathway_Homo sapiens_hsa040121.06175095
43Type II diabetes mellitus_Homo sapiens_hsa049301.04140330
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98544899
45Estrogen signaling pathway_Homo sapiens_hsa049150.97147416
46Melanogenesis_Homo sapiens_hsa049160.95671611
47Prion diseases_Homo sapiens_hsa050200.95109209
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93311848
49Dorso-ventral axis formation_Homo sapiens_hsa043200.92240529
50Axon guidance_Homo sapiens_hsa043600.87234127
51Arginine biosynthesis_Homo sapiens_hsa002200.84699843
52Phototransduction_Homo sapiens_hsa047440.83339857
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.81968079
54Circadian rhythm_Homo sapiens_hsa047100.81471043
55Thyroid hormone synthesis_Homo sapiens_hsa049180.79676315
56Cardiac muscle contraction_Homo sapiens_hsa042600.77798631
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77347313
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75738879
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73846811
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.72574844
61Pancreatic secretion_Homo sapiens_hsa049720.72509460
62MAPK signaling pathway_Homo sapiens_hsa040100.70610860
63Oocyte meiosis_Homo sapiens_hsa041140.70122113
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.69011191
65Focal adhesion_Homo sapiens_hsa045100.68687615
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65793663
67ECM-receptor interaction_Homo sapiens_hsa045120.65688859
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62491797
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61773734
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59254422
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58724278
72Dilated cardiomyopathy_Homo sapiens_hsa054140.56956640
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55945269
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55315069
75Choline metabolism in cancer_Homo sapiens_hsa052310.54919926
76Rap1 signaling pathway_Homo sapiens_hsa040150.54754953
77Ras signaling pathway_Homo sapiens_hsa040140.54700549
78Hippo signaling pathway_Homo sapiens_hsa043900.54624308
79Glucagon signaling pathway_Homo sapiens_hsa049220.54427506
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.52650522
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51150924
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50640709
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49243277
84Inositol phosphate metabolism_Homo sapiens_hsa005620.48256213
85Arginine and proline metabolism_Homo sapiens_hsa003300.48063061
86AMPK signaling pathway_Homo sapiens_hsa041520.47996092
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46742799
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46368361
89Rheumatoid arthritis_Homo sapiens_hsa053230.45719518
90Fatty acid biosynthesis_Homo sapiens_hsa000610.45404199
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44464680
92VEGF signaling pathway_Homo sapiens_hsa043700.44417636
93African trypanosomiasis_Homo sapiens_hsa051430.43757961
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42391415
95Endocytosis_Homo sapiens_hsa041440.40406610
96Protein digestion and absorption_Homo sapiens_hsa049740.40326847
97Renal cell carcinoma_Homo sapiens_hsa052110.39625238
98Insulin signaling pathway_Homo sapiens_hsa049100.39146671
99Melanoma_Homo sapiens_hsa052180.38642104
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38262009
101Proteoglycans in cancer_Homo sapiens_hsa052050.38009628
102Bile secretion_Homo sapiens_hsa049760.37875554
103Endometrial cancer_Homo sapiens_hsa052130.37791488
104Type I diabetes mellitus_Homo sapiens_hsa049400.37278828
105Amoebiasis_Homo sapiens_hsa051460.37229944
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37118286
107Alcoholism_Homo sapiens_hsa050340.34715578
108Wnt signaling pathway_Homo sapiens_hsa043100.34281811
109Non-small cell lung cancer_Homo sapiens_hsa052230.34217616
110mTOR signaling pathway_Homo sapiens_hsa041500.31113398
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30751989
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30489399
113Phagosome_Homo sapiens_hsa041450.29926067
114Chemokine signaling pathway_Homo sapiens_hsa040620.28089932
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27232527
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.26390771
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26215280
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25700358

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