KCNJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.01346911
2response to parathyroid hormone (GO:0071107)9.00431822
3polyol transport (GO:0015791)8.84428238
4* excretion (GO:0007588)8.53091792
5urate metabolic process (GO:0046415)8.39845645
6response to mercury ion (GO:0046689)8.37465262
7drug transmembrane transport (GO:0006855)8.01165223
8lysine metabolic process (GO:0006553)7.47894675
9lysine catabolic process (GO:0006554)7.47894675
10metanephric nephron tubule development (GO:0072234)7.15554122
11metanephric tubule development (GO:0072170)7.15554122
12organic cation transport (GO:0015695)6.84804047
13drug transport (GO:0015893)6.72283654
14positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)6.65770507
15phosphate ion transport (GO:0006817)6.60422537
16metanephric nephron epithelium development (GO:0072243)6.57599487
17response to lead ion (GO:0010288)6.53519882
18* renal absorption (GO:0070293)6.46095921
19response to thyroid hormone (GO:0097066)6.39797665
20positive regulation of catenin import into nucleus (GO:0035413)6.30140057
21activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)6.29830799
22metanephric epithelium development (GO:0072207)6.15658518
23positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.10555370
24negative regulation of cholesterol transport (GO:0032375)6.05335702
25negative regulation of sterol transport (GO:0032372)6.05335702
26quaternary ammonium group transport (GO:0015697)5.77513327
27response to magnesium ion (GO:0032026)5.69854612
28phosphate ion transmembrane transport (GO:0035435)5.53062735
29ethanol oxidation (GO:0006069)5.35630601
30one-carbon compound transport (GO:0019755)5.31004570
31nephron tubule development (GO:0072080)5.21460472
32regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.18236731
33mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.17135124
34negative regulation of metanephros development (GO:0072217)5.15612064
35tricarboxylic acid metabolic process (GO:0072350)5.14134856
36valine metabolic process (GO:0006573)5.13037480
37aspartate family amino acid catabolic process (GO:0009068)5.11542104
38hyperosmotic response (GO:0006972)5.09007919
39glyoxylate metabolic process (GO:0046487)5.06561845
40sodium-independent organic anion transport (GO:0043252)5.04625014
41regulation of apoptotic process involved in morphogenesis (GO:1902337)5.04609809
42collecting duct development (GO:0072044)5.02445299
43nephron tubule formation (GO:0072079)5.00966099
44cysteine metabolic process (GO:0006534)4.94220229
45inositol metabolic process (GO:0006020)4.88467453
46branched-chain amino acid metabolic process (GO:0009081)4.84417186
47drug catabolic process (GO:0042737)4.74455898
48short-chain fatty acid metabolic process (GO:0046459)4.74421726
49actin filament depolymerization (GO:0030042)4.70822333
50modified amino acid transport (GO:0072337)4.70542629
51cellular response to ammonium ion (GO:0071242)4.70413019
52regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.68338221
53renal tubule development (GO:0061326)4.61833848
54response to growth hormone (GO:0060416)4.53739041
55exogenous drug catabolic process (GO:0042738)4.48087885
56response to vitamin A (GO:0033189)4.47532284
57vitamin D metabolic process (GO:0042359)4.46012641
58nonribosomal peptide biosynthetic process (GO:0019184)4.41653404
59trivalent inorganic anion homeostasis (GO:0072506)4.36967994
60phosphate ion homeostasis (GO:0055062)4.36967994
61branched-chain amino acid catabolic process (GO:0009083)4.36340212
62bone remodeling (GO:0046849)4.31174325
63toxin transport (GO:1901998)4.31132101
642-oxoglutarate metabolic process (GO:0006103)4.28875159
65nephron epithelium development (GO:0072009)4.27584547
66homocysteine metabolic process (GO:0050667)4.24188149
67regulation of protein localization to cell surface (GO:2000008)4.22952467
68glycoside metabolic process (GO:0016137)4.19396528
69carnitine transport (GO:0015879)4.11125337
70amino-acid betaine transport (GO:0015838)4.11125337
71positive regulation of peptidyl-threonine phosphorylation (GO:0010800)4.11032420
72glomerular visceral epithelial cell development (GO:0072015)4.08841457
73cell volume homeostasis (GO:0006884)4.08058623
74regulation of fever generation (GO:0031620)4.07566891
75indole-containing compound catabolic process (GO:0042436)4.04877335
76indolalkylamine catabolic process (GO:0046218)4.04877335
77tryptophan catabolic process (GO:0006569)4.04877335
78negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.02873305
79fatty acid oxidation (GO:0019395)4.00771143
80mammary gland alveolus development (GO:0060749)4.00198162
81positive regulation of heat generation (GO:0031652)3.98601153
82cellular ketone body metabolic process (GO:0046950)3.97114412
83amino-acid betaine metabolic process (GO:0006577)3.96924065
84pattern specification involved in kidney development (GO:0061004)3.94130131
85regulation of cholesterol efflux (GO:0010874)3.94008698
86lipid oxidation (GO:0034440)3.93454790
87glutathione biosynthetic process (GO:0006750)3.92464654
88response to salt stress (GO:0009651)3.92340185
89aromatic amino acid family catabolic process (GO:0009074)3.91954702
90ERK1 and ERK2 cascade (GO:0070371)3.91583159
91carnitine metabolic process (GO:0009437)3.89996581
92fatty acid beta-oxidation (GO:0006635)3.85461843
93tryptophan metabolic process (GO:0006568)3.77167671
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.74480980
95L-phenylalanine metabolic process (GO:0006558)3.74480980
96vitamin transmembrane transport (GO:0035461)3.73219661
97response to water (GO:0009415)3.71854397
98nephron epithelium morphogenesis (GO:0072088)3.71447987
99nephron tubule morphogenesis (GO:0072078)3.71447987
100water transport (GO:0006833)3.68779047
101fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68403329
102protein depolymerization (GO:0051261)3.67437364
103beta-amyloid metabolic process (GO:0050435)3.66855209
104L-phenylalanine catabolic process (GO:0006559)3.64391084
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.64391084
106fructose metabolic process (GO:0006000)3.63197674
107regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.62397684
108transepithelial transport (GO:0070633)3.62338861
109vitamin transport (GO:0051180)3.61064867
110cellular modified amino acid catabolic process (GO:0042219)3.59355800
111positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.58599497
112glomerular epithelial cell development (GO:0072310)3.57604662
113acetyl-CoA metabolic process (GO:0006084)3.51500894
114ethanol metabolic process (GO:0006067)3.50772281
115peptide catabolic process (GO:0043171)3.49691415
116sulfur compound transport (GO:0072348)3.45125656
117response to copper ion (GO:0046688)3.44585233
118NADH metabolic process (GO:0006734)3.42450865
119ketone body metabolic process (GO:1902224)3.38703838
120positive regulation of ERBB signaling pathway (GO:1901186)3.38309419
121tricarboxylic acid cycle (GO:0006099)3.37727950
122S-adenosylmethionine metabolic process (GO:0046500)3.37726515
123regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.37545800
124kynurenine metabolic process (GO:0070189)3.37482255
125surfactant homeostasis (GO:0043129)3.35449504
126serine family amino acid catabolic process (GO:0009071)3.34201978
127primary alcohol catabolic process (GO:0034310)3.32445647
128regulation of anion transport (GO:0044070)3.32353061
129sulfur amino acid catabolic process (GO:0000098)3.30337734
130proline metabolic process (GO:0006560)3.28226245
131L-methionine salvage (GO:0071267)3.27150802
132L-methionine biosynthetic process (GO:0071265)3.27150802
133amino acid salvage (GO:0043102)3.27150802
134fluid transport (GO:0042044)3.25439603
135cell differentiation involved in metanephros development (GO:0072202)3.25074146
136indole-containing compound metabolic process (GO:0042430)3.24172368
137peptide biosynthetic process (GO:0043043)3.23129790
138calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.20243483
139renal tubule morphogenesis (GO:0061333)3.18456837
140glutamate metabolic process (GO:0006536)3.17249298
141positive regulation of digestive system process (GO:0060456)3.16940521
142serine family amino acid metabolic process (GO:0009069)3.16619632
143* sodium ion transport (GO:0006814)3.16461004
144L-ascorbic acid metabolic process (GO:0019852)3.16244955
145fatty acid catabolic process (GO:0009062)3.15075990
146regulation of heat generation (GO:0031650)3.14441858
147cellular amino acid catabolic process (GO:0009063)3.13420365
148response to phenylpropanoid (GO:0080184)3.13074596
149regulation of calcium ion import (GO:0090279)3.10716897
150response to lithium ion (GO:0010226)3.10146180
151glutathione derivative metabolic process (GO:1901685)3.10018520
152negative regulation of lipid transport (GO:0032369)3.07870952
153inorganic anion transport (GO:0015698)3.07694560
154urogenital system development (GO:0001655)3.06720740
155regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.04975903
156regulation of mesenchymal cell apoptotic process (GO:2001053)3.04225247
157chloride transmembrane transport (GO:1902476)3.01381380
158* renal system process (GO:0003014)3.00198478
159mesonephros development (GO:0001823)2.92419745
160inorganic anion transmembrane transport (GO:0098661)2.88783414
161positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.87692351
162histamine transport (GO:0051608)2.86284256
163regulation of catenin import into nucleus (GO:0035412)2.82725109
164chloride transport (GO:0006821)2.79822730
165regulation of stem cell maintenance (GO:2000036)2.79750855
166kidney epithelium development (GO:0072073)2.77306307
167negative regulation of kidney development (GO:0090185)2.76913364
168flavonoid metabolic process (GO:0009812)2.76777563
169regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.70643827
170positive regulation of metanephros development (GO:0072216)2.69088955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.28330549
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.61712356
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.26745425
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.19397861
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.16694933
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.89485120
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.89052838
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.70193472
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.67755212
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.52422086
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.43550186
12GATA1_22025678_ChIP-Seq_K562_Human2.41484749
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23109551
14* VDR_24787735_ChIP-Seq_THP-1_Human2.20383468
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.20182889
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15098215
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13442986
18GBX2_23144817_ChIP-Seq_PC3_Human2.04639355
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.02496105
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92363268
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91202006
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89032902
23CLOCK_20551151_ChIP-Seq_293T_Human1.86232544
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.84981686
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.82433778
26SALL4_18804426_ChIP-ChIP_XEN_Mouse1.80729816
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.79200528
28KLF4_18555785_Chip-Seq_ESCs_Mouse1.77970133
29VDR_22108803_ChIP-Seq_LS180_Human1.76930798
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.72985304
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70453739
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61601953
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.57778220
34P53_22127205_ChIP-Seq_FIBROBLAST_Human1.57529829
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57470395
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55027223
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.50172067
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49306354
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.48253233
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.45899445
41GATA4_25053715_ChIP-Seq_YYC3_Human1.41265040
42AHR_22903824_ChIP-Seq_MCF-7_Human1.40724121
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39873920
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.39674481
45SMAD3_21741376_ChIP-Seq_HESCs_Human1.39397672
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39340874
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.38369264
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37989488
49TAF15_26573619_Chip-Seq_HEK293_Human1.36840453
50OCT4_18555785_Chip-Seq_ESCs_Mouse1.35954638
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32654329
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31542785
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.30056488
54SMAD4_21799915_ChIP-Seq_A2780_Human1.29867837
55SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28567090
56P300_18555785_Chip-Seq_ESCs_Mouse1.28138765
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28025023
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.27146390
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26102925
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.25725952
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25489390
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.25369960
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25124468
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.24845842
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.24680576
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22708351
67P53_22387025_ChIP-Seq_ESCs_Mouse1.22201830
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20908199
69* RXR_22108803_ChIP-Seq_LS180_Human1.19026523
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17453752
71PU1_27457419_Chip-Seq_LIVER_Mouse1.17398023
72ZFX_18555785_Chip-Seq_ESCs_Mouse1.17305837
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17198899
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14426330
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.13289597
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13180292
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12609332
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12560174
79CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12396350
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12202117
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12202117
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12123800
83HNF4A_19822575_ChIP-Seq_HepG2_Human1.12074542
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11640029
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11410188
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.11392814
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.11392814
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11319290
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10995786
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10119127
91KDM2B_26808549_Chip-Seq_REH_Human1.09748166
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08439881
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07196699
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06534527
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06381137
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06040772
97SOX2_20726797_ChIP-Seq_SW620_Human1.05985212
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05141813
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.05139407
100* CBP_21632823_ChIP-Seq_H3396_Human1.04991175
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.03944171
102DROSHA_22980978_ChIP-Seq_HELA_Human1.03481140
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03479746
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.02306259
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01169835
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01084094
107GATA6_25053715_ChIP-Seq_YYC3_Human1.01078453
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00787410
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00216202
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99709831
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99709831
112HTT_18923047_ChIP-ChIP_STHdh_Human0.99016066
113CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98747352
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97142612
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96842232
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96115678
117JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95980680
118SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95876392
119NFYA_21822215_ChIP-Seq_K562_Human0.95742239
120NMYC_18555785_Chip-Seq_ESCs_Mouse0.94535815
121CRX_20693478_ChIP-Seq_RETINA_Mouse0.94448759
122TBL1_22424771_ChIP-Seq_293T_Human0.94388612
123* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94191823
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93847093
125EGR1_19032775_ChIP-ChIP_M12_Human0.93780609
126CTCF_27219007_Chip-Seq_Bcells_Human0.93155946
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92905609
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92878964
129TP53_18474530_ChIP-ChIP_U2OS_Human0.92745967
130* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92035836
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91992108
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91803760
133RACK7_27058665_Chip-Seq_MCF-7_Human0.91180859
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91178413
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91077886
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90563428
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.89201685
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88080678
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87691513
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87482835
141* EZH2_27294783_Chip-Seq_ESCs_Mouse0.87133007
142LXR_22292898_ChIP-Seq_THP-1_Human0.87029077
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86344836
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.85952411
145ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84292529
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83696383
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83301612
148CJUN_26792858_Chip-Seq_BT549_Human0.82069637
149CDX2_22108803_ChIP-Seq_LS180_Human0.82021394
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81902812
151GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80328754
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79980382
153AR_21572438_ChIP-Seq_LNCaP_Human0.79849361
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79387334
155* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.78966205
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77799283
157* TP63_23658742_ChIP-Seq_EP156T_Human0.77263150
158AR_21909140_ChIP-Seq_LNCAP_Human0.77233299
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75902655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004043_abnormal_pH_regulation7.52606017
2MP0003195_calcinosis6.72344559
3MP0005360_urolithiasis5.66597355
4MP0004019_abnormal_vitamin_homeostasis4.85124141
5* MP0001756_abnormal_urination4.56667939
6MP0005332_abnormal_amino_acid4.31249561
7* MP0009643_abnormal_urine_homeostasis4.11766384
8* MP0001765_abnormal_ion_homeostasis3.77216416
9MP0002138_abnormal_hepatobiliary_system3.43365134
10* MP0002136_abnormal_kidney_physiology3.23823222
11MP0002139_abnormal_hepatobiliary_system3.12248107
12MP0008875_abnormal_xenobiotic_pharmacok3.09667258
13MP0005377_hearing/vestibular/ear_phenot3.01304863
14MP0003878_abnormal_ear_physiology3.01304863
15* MP0005636_abnormal_mineral_homeostasis3.01191369
16MP0008961_abnormal_basal_metabolism2.53165416
17MP0004885_abnormal_endolymph2.28365460
18MP0000538_abnormal_urinary_bladder2.17478561
19MP0003252_abnormal_bile_duct2.12681248
20MP0001958_emphysema2.02130210
21MP0005365_abnormal_bile_salt1.76433267
22MP0005085_abnormal_gallbladder_physiolo1.60628631
23MP0003186_abnormal_redox_activity1.49427377
24MP0005058_abnormal_lysosome_morphology1.47797161
25MP0002168_other_aberrant_phenotype1.47765896
26MP0000230_abnormal_systemic_arterial1.44144345
27MP0005584_abnormal_enzyme/coenzyme_acti1.34301817
28MP0002876_abnormal_thyroid_physiology1.33373304
29MP0005451_abnormal_body_composition1.19076565
30MP0002928_abnormal_bile_duct1.17861371
31* MP0002135_abnormal_kidney_morphology1.17574553
32MP0010386_abnormal_urinary_bladder1.13434681
33MP0003045_fibrosis1.12780294
34MP0003300_gastrointestinal_ulcer1.12592278
35MP0005319_abnormal_enzyme/_coenzyme1.09762862
36MP0003283_abnormal_digestive_organ1.07897187
37MP0004742_abnormal_vestibular_system1.06578655
38MP0005084_abnormal_gallbladder_morpholo1.05831684
39MP0000534_abnormal_ureter_morphology0.99828616
40MP0005535_abnormal_body_temperature0.99073531
41MP0004264_abnormal_extraembryonic_tissu0.98402107
42MP0000747_muscle_weakness0.97572345
43MP0005670_abnormal_white_adipose0.90969866
44MP0006036_abnormal_mitochondrial_physio0.87428214
45MP0001270_distended_abdomen0.83624041
46MP0001764_abnormal_homeostasis0.83230317
47MP0005165_increased_susceptibility_to0.80528269
48MP0009672_abnormal_birth_weight0.78590872
49MP0003959_abnormal_lean_body0.77803326
50MP0003806_abnormal_nucleotide_metabolis0.77744861
51MP0005666_abnormal_adipose_tissue0.76783566
52MP0005395_other_phenotype0.76719624
53MP0004147_increased_porphyrin_level0.76380248
54MP0003879_abnormal_hair_cell0.73465712
55MP0002089_abnormal_postnatal_growth/wei0.73407790
56MP0002896_abnormal_bone_mineralization0.73330683
57MP0003329_amyloid_beta_deposits0.67916817
58MP0002118_abnormal_lipid_homeostasis0.67409789
59MP0005167_abnormal_blood-brain_barrier0.66559042
60MP0000678_abnormal_parathyroid_gland0.64876564
61* MP0009642_abnormal_blood_homeostasis0.64634116
62MP0001485_abnormal_pinna_reflex0.64258309
63MP0003183_abnormal_peptide_metabolism0.62591799
64MP0003638_abnormal_response/metabolism_0.61954385
65MP0009764_decreased_sensitivity_to0.60773457
66MP0005375_adipose_tissue_phenotype0.59280110
67MP0003646_muscle_fatigue0.58646013
68MP0003191_abnormal_cellular_cholesterol0.58104155
69MP0010368_abnormal_lymphatic_system0.57334521
70MP0002971_abnormal_brown_adipose0.57058382
71MP0004484_altered_response_of0.56967252
72MP0004272_abnormal_basement_membrane0.56625316
73MP0005220_abnormal_exocrine_pancreas0.56169974
74MP0008004_abnormal_stomach_pH0.55965942
75MP0005408_hypopigmentation0.54398854
76MP0003172_abnormal_lysosome_physiology0.54284999
77MP0001879_abnormal_lymphatic_vessel0.54188649
78MP0000371_diluted_coat_color0.53088436
79MP0001177_atelectasis0.52533093
80MP0002098_abnormal_vibrissa_morphology0.51586091
81MP0002796_impaired_skin_barrier0.50723741
82MP0010329_abnormal_lipoprotein_level0.50397446
83MP0003724_increased_susceptibility_to0.49919180
84MP0001666_abnormal_nutrient_absorption0.49620548
85MP0004858_abnormal_nervous_system0.49479337
86MP0001963_abnormal_hearing_physiology0.49262565
87* MP0002069_abnormal_eating/drinking_beha0.48629025
88MP0010234_abnormal_vibrissa_follicle0.47196140
89MP0008872_abnormal_physiological_respon0.46731345
90MP0003303_peritoneal_inflammation0.44620181
91MP0003943_abnormal_hepatobiliary_system0.44443511
92MP0008874_decreased_physiological_sensi0.44432661
93MP0006054_spinal_hemorrhage0.43507809
94MP0003953_abnormal_hormone_level0.42773568
95MP0001664_abnormal_digestion0.41668671
96MP0000604_amyloidosis0.40291504
97MP0003795_abnormal_bone_structure0.39098340
98MP0002078_abnormal_glucose_homeostasis0.38977391
99MP0001663_abnormal_digestive_system0.38899037
100MP0003011_delayed_dark_adaptation0.38569197
101MP0003315_abnormal_perineum_morphology0.38466618
102MP0000026_abnormal_inner_ear0.36802069
103MP0002998_abnormal_bone_remodeling0.36765649
104MP0001731_abnormal_postnatal_growth0.36534255
105MP0000609_abnormal_liver_physiology0.36482319
106MP0001845_abnormal_inflammatory_respons0.35229531
107MP0005501_abnormal_skin_physiology0.34866268
108MP0003690_abnormal_glial_cell0.34429919
109MP0003938_abnormal_ear_development0.34304945
110MP0003075_altered_response_to0.33216451
111MP0008469_abnormal_protein_level0.32798876
112MP0005025_abnormal_response_to0.32744639
113MP0005388_respiratory_system_phenotype0.32067265
114MP0002133_abnormal_respiratory_system0.32067265
115MP0001784_abnormal_fluid_regulation0.31281680
116MP0001661_extended_life_span0.31216977
117MP0009703_decreased_birth_body0.28104013
118* MP0001191_abnormal_skin_condition0.28066937
119MP0001944_abnormal_pancreas_morphology0.25899359
120MP0000681_abnormal_thyroid_gland0.24266332
121MP0003941_abnormal_skin_development0.22681320
122MP0002115_abnormal_skeleton_extremities0.21972967
123MP0004130_abnormal_muscle_cell0.21922472
124MP0006082_CNS_inflammation0.20276186
125MP0000920_abnormal_myelination0.19820318
126MP0004215_abnormal_myocardial_fiber0.16981221
127MP0002082_postnatal_lethality0.15875486
128MP0010770_preweaning_lethality0.15875486
129MP0003633_abnormal_nervous_system0.15740196
130MP0005671_abnormal_response_to0.14645693
131MP0004233_abnormal_muscle_weight0.14355801
132MP0000631_abnormal_neuroendocrine_gland0.12858759
133MP0002877_abnormal_melanocyte_morpholog0.12679717
134MP0003866_abnormal_defecation0.11957773
135MP0003091_abnormal_cell_migration0.11774261
136MP0005464_abnormal_platelet_physiology0.11198650
137MP0003137_abnormal_impulse_conducting0.11195737

Predicted human phenotypes

RankGene SetZ-score
1* Increased circulating renin level (HP:0000848)8.63070607
2* Polyuria (HP:0000103)8.47290077
3* Abnormality of chloride homeostasis (HP:0011422)8.37336442
4* Hypomagnesemia (HP:0002917)8.15047780
5* Abnormal urine output (HP:0012590)7.82689523
6* Hyperactive renin-angiotensin system (HP:0000841)7.72748084
7* Abnormality of renal excretion (HP:0011036)7.11232040
8* Abnormality of magnesium homeostasis (HP:0004921)6.87318231
9* Hyperaldosteronism (HP:0000859)6.75343526
10* Renal salt wasting (HP:0000127)6.59143846
11* Polydipsia (HP:0001959)6.24575291
12* Abnormal drinking behavior (HP:0030082)6.24575291
13Gout (HP:0001997)6.06260579
14* Alkalosis (HP:0001948)5.90434955
15* Tetany (HP:0001281)5.86462768
16* Abnormality of renin-angiotensin system (HP:0000847)5.58564837
17* Hypokalemia (HP:0002900)4.83629063
18Increased purine levels (HP:0004368)4.34449607
19Hyperuricemia (HP:0002149)4.34449607
20Abnormality of sodium homeostasis (HP:0010931)4.22167353
21* Abnormality of potassium homeostasis (HP:0011042)4.00165032
22Proximal tubulopathy (HP:0000114)3.82557338
23Hyponatremia (HP:0002902)3.77310212
24Hyperglycinuria (HP:0003108)3.62011861
25* Hypercalciuria (HP:0002150)3.58963694
26Abnormality of purine metabolism (HP:0004352)3.58033267
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.20135343
28Renal tubular acidosis (HP:0001947)3.19373929
29* Adrenal overactivity (HP:0002717)3.05220287
30Ketoacidosis (HP:0001993)3.04410431
31Decreased circulating renin level (HP:0003351)2.99994531
32Abnormality of serine family amino acid metabolism (HP:0010894)2.95757587
33Abnormality of glycine metabolism (HP:0010895)2.95757587
34* Abnormality of fatty-acid metabolism (HP:0004359)2.83496463
35Generalized aminoaciduria (HP:0002909)2.81471452
36Abnormality of urine glucose concentration (HP:0011016)2.63158209
37Glycosuria (HP:0003076)2.63158209
38* Dehydration (HP:0001944)2.61729811
39* Nephrocalcinosis (HP:0000121)2.55717914
40Abnormality of nucleobase metabolism (HP:0010932)2.51379562
41Ketosis (HP:0001946)2.45927597
42Tubulointerstitial fibrosis (HP:0005576)2.39010050
43Tubular atrophy (HP:0000092)2.31368868
44Hyperphosphaturia (HP:0003109)2.29798366
45Abnormal urine phosphate concentration (HP:0012599)2.18953096
46Hyperglycinemia (HP:0002154)2.17635547
47* Chondrocalcinosis (HP:0000934)2.09023062
48Potter facies (HP:0002009)2.06168579
49Facial shape deformation (HP:0011334)2.06168579
50Nephrolithiasis (HP:0000787)2.05770828
51Abnormality of proline metabolism (HP:0010907)2.03557360
52Hydroxyprolinuria (HP:0003080)2.03557360
53Renal tubular dysfunction (HP:0000124)2.01797661
54* Vomiting (HP:0002013)2.01449368
55Bilateral sensorineural hearing impairment (HP:0008619)2.01289533
56* Metabolic alkalosis (HP:0200114)10.1652076
57* Hypokalemic alkalosis (HP:0001949)10.1434386
58Neonatal onset (HP:0003623)1.99757208
59* Abnormality of Sharpey fibers (HP:0100685)1.97824027
60Glomerulosclerosis (HP:0000096)1.93123288
61Hyperkalemia (HP:0002153)1.91058164
62Focal segmental glomerulosclerosis (HP:0000097)1.91019436
63Vascular calcification (HP:0004934)1.84343179
64Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83880237
65Metabolic acidosis (HP:0001942)1.82868665
66Dicarboxylic aciduria (HP:0003215)1.82868606
67Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82868606
68Hypophosphatemia (HP:0002148)1.82791653
69Delayed epiphyseal ossification (HP:0002663)1.81619909
70Vacuolated lymphocytes (HP:0001922)1.80941683
71Abnormality of the renal cortex (HP:0011035)1.80606425
72Delayed CNS myelination (HP:0002188)1.78261886
73Abnormality of renal resorption (HP:0011038)1.78001799
74Enlarged kidneys (HP:0000105)1.75817118
75Hyperammonemia (HP:0001987)1.75663930
76Nephrogenic diabetes insipidus (HP:0009806)1.73777179
77Rickets (HP:0002748)1.70534465
78Widely patent fontanelles and sutures (HP:0004492)1.68812610
79* Hypotension (HP:0002615)1.67477575
80* Generalized muscle weakness (HP:0003324)1.66177749
81Cardiovascular calcification (HP:0011915)1.62887600
82Irritability (HP:0000737)1.62596190
83Bicornuate uterus (HP:0000813)1.60001960
84Tubulointerstitial abnormality (HP:0001969)1.56007153
85Metaphyseal cupping (HP:0003021)1.55770810
86Methylmalonic aciduria (HP:0012120)1.51722236
87Lethargy (HP:0001254)1.51603130
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.48135816
89Abnormality of the renal medulla (HP:0100957)1.47455282
90Lymphangioma (HP:0100764)1.45583478
91Elevated alkaline phosphatase (HP:0003155)1.44634727
92Hypothermia (HP:0002045)1.44600611
93Abnormality of calcium-phosphate metabolism (HP:0100530)1.41492552
94Abnormality of sulfur amino acid metabolism (HP:0004339)1.40405404
95Confusion (HP:0001289)1.39944919
96Abnormality of aromatic amino acid family metabolism (HP:0004338)1.38601248
97Metaphyseal dysplasia (HP:0100255)1.38018164
98Thin bony cortex (HP:0002753)1.36322943
99Tachypnea (HP:0002789)1.33722951
100Hypoglycemic coma (HP:0001325)1.32492819
101Abnormal enzyme/coenzyme activity (HP:0012379)1.28844036
102Intellectual disability, moderate (HP:0002342)1.28314853
103Abnormal eating behavior (HP:0100738)1.27318644
104Nausea (HP:0002018)1.26757336
105* Premature birth (HP:0001622)1.26104806
106Abnormality of alkaline phosphatase activity (HP:0004379)1.25424892
107Malnutrition (HP:0004395)1.21469066
108Abnormality of serum amino acid levels (HP:0003112)1.21404929
109Dysostosis multiplex (HP:0000943)1.19413618
110Abnormal tarsal ossification (HP:0008369)1.14233458
111Neonatal death (HP:0003811)1.12072664
112Enlarged epiphyses (HP:0010580)1.09461482
113* Osteopenia (HP:0000938)1.07960105
114* Paresthesia (HP:0003401)1.06811519
115Persistence of primary teeth (HP:0006335)1.05366744
116Hypophosphatemic rickets (HP:0004912)1.02738863
117Thyroid-stimulating hormone excess (HP:0002925)0.98345786
118Esophageal varix (HP:0002040)0.97514357
119Metaphyseal irregularity (HP:0003025)0.94983769
120Osteomalacia (HP:0002749)0.94757551
121Abnormality of macular pigmentation (HP:0008002)0.90122707
122Juvenile onset (HP:0003621)0.88097977
123Abnormality of the fingertips (HP:0001211)0.87737932
124* Polyhydramnios (HP:0001561)0.87213141
125Paralysis (HP:0003470)0.86173473
126Hyperphosphatemia (HP:0002905)0.82557769
127Amelogenesis imperfecta (HP:0000705)0.77894264
128Abnormal foot bone ossification (HP:0010675)0.77355643
129Nephropathy (HP:0000112)0.75414591
130Choanal stenosis (HP:0000452)0.74302244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR17.96148945
2WNK47.95086987
3STK393.99260914
4TIE13.33558561
5WNK310.2399719
6BCKDK1.94857261
7STK38L1.84879334
8WNK11.79708483
9MST41.38656349
10PDK21.36016343
11PDK41.29606888
12PDK31.29606888
13SIK31.16784208
14STK380.92551780
15INSRR0.89996160
16NEK10.85733767
17PINK10.75490231
18PRKD30.72167556
19MST1R0.70218257
20ERN10.69728736
21* SGK2230.66301349
22* SGK4940.66301349
23SIK10.63895012
24TGFBR20.63793600
25GRK10.61139382
26LRRK20.56590355
27SIK20.52101616
28MAPK150.51830378
29BMX0.51297391
30PRKD20.51190643
31PRKAA10.49797103
32CAMKK20.45771221
33MAP3K70.44621199
34EPHB20.42932370
35PIK3CG0.41229667
36PRKCI0.37824808
37EPHB10.35196605
38MARK30.34942746
39MAP3K120.34613496
40* SGK10.33578268
41STK100.32149785
42FGFR40.31416429
43GSK3A0.31255539
44PRKAA20.30384124
45LATS10.29728527
46TEC0.29326300
47PAK30.28636568
48SCYL20.26953982
49PDPK10.26542020
50PRKCH0.24690610
51PRKCZ0.24337543
52* SGK20.23086830
53CAMK1D0.22783057
54PAK40.22662799
55CAMK1G0.22586274
56DAPK20.21968218
57PTK20.21936478
58PRKCE0.21134597
59MAP3K30.19514510
60FER0.18957992
61GRK60.18149617
62IRAK20.17269392
63CSNK1A10.17038581
64* SGK30.16824951
65RIPK40.16228754
66ZAP700.16140640
67PTK60.15860935
68MAP2K20.15183389
69BTK0.14715537
70ADRBK20.14389479
71NME10.14280938
72KDR0.13264277
73TYK20.12694851
74PRKACG0.12539153
75NTRK10.12220303
76KSR20.11871773
77CAMKK10.11824941
78PRKCG0.11557787
79MARK20.11551033
80ABL20.11222335
81MINK10.11174600
82AKT20.10812064
83MYLK0.10802292
84NLK0.10587566
85CSK0.10066884
86MAPK110.10060620
87MAPK120.09223235
88CAMK40.08805640
89EPHA40.08418822
90BLK0.08335410
91KSR10.08203547
92ITK0.08199285
93RIPK10.08134588
94MAP2K60.07672639
95* PRKACA0.07577006
96MAP3K140.07363228
97ACVR1B0.07260161
98PRKCB0.07248996
99PDK10.07091390
100MAP3K20.07065165
101* PRKCA0.06678969
102GRK70.06139158
103INSR0.06050501
104JAK10.05988688
105DYRK1B0.05849621
106NEK90.05772807
107YES10.05645542
108TXK0.05373340
109ADRBK10.05229277
110TRPM70.05044939
111SYK0.04820409
112CSF1R0.04535131
113MAP3K10.04410088
114PRKCQ0.04038631
115HCK0.03944001
116FGR0.03802321
117NEK60.03729713
118TAOK10.03714922
119IRAK10.03068237
120RET0.02974745
121JAK20.02971680
122TESK10.02915483
123* PRKCD0.02822055
124CDC42BPA0.02815042
125ABL10.02117688
126MET0.02094117
127PTK2B0.02085741
128MAP3K110.02039740
129MAP2K30.01894323
130CSNK1A1L0.01706688
131MAP3K130.01456295
132LCK0.01296543
133MAP2K10.01202170
134FES0.01177521
135TGFBR10.00668613
136FYN0.00249877
137PRKD1-0.0247698
138PDGFRB-0.0241862
139STK3-0.0210899
140STK24-0.0175860
141RAF1-0.0175045
142STK11-0.0089121
143LYN-0.0075030
144MAP3K5-0.0058291
145RPS6KA3-0.0039180
146PRPF4B-0.0020309
147FGFR3-0.0015781
148MATK-0.0009469
149IRAK3-0.0006672
150IGF1R-0.0005971
151CDK3-0.0005483

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.93505662
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43183139
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.24808928
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.22349387
5Butanoate metabolism_Homo sapiens_hsa006503.17229091
6Propanoate metabolism_Homo sapiens_hsa006403.11363110
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.94807829
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.74706467
9Fatty acid degradation_Homo sapiens_hsa000712.72530843
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.56915286
11Sulfur metabolism_Homo sapiens_hsa009202.48523038
12Collecting duct acid secretion_Homo sapiens_hsa049662.45485128
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42049205
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36535812
15Peroxisome_Homo sapiens_hsa041462.17011421
16Pyruvate metabolism_Homo sapiens_hsa006202.04080607
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99431360
18Bile secretion_Homo sapiens_hsa049761.97334379
19Tryptophan metabolism_Homo sapiens_hsa003801.90751957
20beta-Alanine metabolism_Homo sapiens_hsa004101.81915309
21Vitamin digestion and absorption_Homo sapiens_hsa049771.79568040
22* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69232743
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66144951
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65671818
25Carbon metabolism_Homo sapiens_hsa012001.62888698
26Fatty acid metabolism_Homo sapiens_hsa012121.59626772
27Endometrial cancer_Homo sapiens_hsa052131.59284328
28Non-small cell lung cancer_Homo sapiens_hsa052231.54813757
29Other glycan degradation_Homo sapiens_hsa005111.52249945
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46571600
31Glutathione metabolism_Homo sapiens_hsa004801.45025922
32Mineral absorption_Homo sapiens_hsa049781.44614266
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44487062
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41293594
35Pancreatic cancer_Homo sapiens_hsa052121.36830589
36Protein digestion and absorption_Homo sapiens_hsa049741.21603283
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19243819
38PPAR signaling pathway_Homo sapiens_hsa033201.17196646
39Lysine degradation_Homo sapiens_hsa003101.16898258
40Phenylalanine metabolism_Homo sapiens_hsa003601.16051876
41Chemical carcinogenesis_Homo sapiens_hsa052041.14703207
42Glioma_Homo sapiens_hsa052141.12419128
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09444586
44Oxidative phosphorylation_Homo sapiens_hsa001901.09325771
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08915648
46Inositol phosphate metabolism_Homo sapiens_hsa005621.03624236
47Tyrosine metabolism_Homo sapiens_hsa003500.99777636
48Arginine biosynthesis_Homo sapiens_hsa002200.99112719
49Melanoma_Homo sapiens_hsa052180.99081115
50Vitamin B6 metabolism_Homo sapiens_hsa007500.98501855
51Arginine and proline metabolism_Homo sapiens_hsa003300.96769535
52Selenocompound metabolism_Homo sapiens_hsa004500.93699376
53FoxO signaling pathway_Homo sapiens_hsa040680.91857789
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90904866
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.89134170
56Fructose and mannose metabolism_Homo sapiens_hsa000510.89131382
57Histidine metabolism_Homo sapiens_hsa003400.88444600
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88349119
59Biosynthesis of amino acids_Homo sapiens_hsa012300.87255972
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78767454
61Gap junction_Homo sapiens_hsa045400.77807337
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.77746408
63Fatty acid elongation_Homo sapiens_hsa000620.75315551
64Thyroid hormone synthesis_Homo sapiens_hsa049180.74775054
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73333505
66Glycerolipid metabolism_Homo sapiens_hsa005610.73103733
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70287831
68Renin-angiotensin system_Homo sapiens_hsa046140.70185559
69ErbB signaling pathway_Homo sapiens_hsa040120.70057690
70Parkinsons disease_Homo sapiens_hsa050120.69968739
71* Gastric acid secretion_Homo sapiens_hsa049710.68090603
72HIF-1 signaling pathway_Homo sapiens_hsa040660.67855505
73Starch and sucrose metabolism_Homo sapiens_hsa005000.67598909
74Retinol metabolism_Homo sapiens_hsa008300.66556644
75Prostate cancer_Homo sapiens_hsa052150.66422045
76Lysosome_Homo sapiens_hsa041420.61012613
77Nitrogen metabolism_Homo sapiens_hsa009100.59277157
78Folate biosynthesis_Homo sapiens_hsa007900.59228534
79Sulfur relay system_Homo sapiens_hsa041220.56903773
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55769875
81Pentose phosphate pathway_Homo sapiens_hsa000300.49886269
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.46577904
83Metabolic pathways_Homo sapiens_hsa011000.46321301
84Phagosome_Homo sapiens_hsa041450.46160636
85Synaptic vesicle cycle_Homo sapiens_hsa047210.44011036
86Alzheimers disease_Homo sapiens_hsa050100.43360129
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.43320162
88Vibrio cholerae infection_Homo sapiens_hsa051100.43141909
89Complement and coagulation cascades_Homo sapiens_hsa046100.41883725
90Cardiac muscle contraction_Homo sapiens_hsa042600.39935107
91Rheumatoid arthritis_Homo sapiens_hsa053230.39860848
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39324926
93Tuberculosis_Homo sapiens_hsa051520.36361221
94ABC transporters_Homo sapiens_hsa020100.36073998
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.34673340
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34267867
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33296386
98Thyroid cancer_Homo sapiens_hsa052160.32114841
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30949155
100Rap1 signaling pathway_Homo sapiens_hsa040150.30753350
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.27196869
102Focal adhesion_Homo sapiens_hsa045100.26001602
103Glucagon signaling pathway_Homo sapiens_hsa049220.24901756
104Endocytosis_Homo sapiens_hsa041440.24577194
105Osteoclast differentiation_Homo sapiens_hsa043800.23047764
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20039445
107Sphingolipid metabolism_Homo sapiens_hsa006000.18666599
108Arachidonic acid metabolism_Homo sapiens_hsa005900.18149520
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18120884
110Dorso-ventral axis formation_Homo sapiens_hsa043200.16237808
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.16203966
112Choline metabolism in cancer_Homo sapiens_hsa052310.15834186
113Circadian rhythm_Homo sapiens_hsa047100.15610466
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15525479
115Huntingtons disease_Homo sapiens_hsa050160.15441454
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15368073
117Renin secretion_Homo sapiens_hsa049240.15314456
118B cell receptor signaling pathway_Homo sapiens_hsa046620.14723843
119Salivary secretion_Homo sapiens_hsa049700.14227913
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.11304381
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10816964
122Hepatitis C_Homo sapiens_hsa051600.10785936
123Bladder cancer_Homo sapiens_hsa052190.07815983
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.07151383
125Galactose metabolism_Homo sapiens_hsa000520.07013908
126Pancreatic secretion_Homo sapiens_hsa049720.06173290
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.05651402
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05260809
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04669596
130Insulin resistance_Homo sapiens_hsa049310.04137499
131Tight junction_Homo sapiens_hsa045300.03530217
132Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0085403
133Insulin secretion_Homo sapiens_hsa04911-0.0074849

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