KCNJ10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)6.08965311
2* central nervous system myelination (GO:0022010)5.85824281
3* axon ensheathment in central nervous system (GO:0032291)5.85824281
4locomotory exploration behavior (GO:0035641)5.04876412
5synaptic vesicle maturation (GO:0016188)5.00498682
6cellular potassium ion homeostasis (GO:0030007)4.73145144
7gamma-aminobutyric acid transport (GO:0015812)4.67902587
8* L-amino acid import (GO:0043092)4.63255761
9neuronal action potential propagation (GO:0019227)4.59482027
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.53970347
11glycine transport (GO:0015816)4.49820569
12sodium ion export (GO:0071436)4.36400817
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.26893580
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.19896638
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.18512034
16glutamate secretion (GO:0014047)4.15119466
17neuron cell-cell adhesion (GO:0007158)4.08558383
18positive regulation of synapse maturation (GO:0090129)4.07539822
19regulation of synaptic vesicle exocytosis (GO:2000300)4.07072514
20synaptic vesicle exocytosis (GO:0016079)3.99574075
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.96230316
22vocalization behavior (GO:0071625)3.92543059
23* myelination (GO:0042552)3.86910652
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86667571
25* axon ensheathment (GO:0008366)3.82707995
26* ensheathment of neurons (GO:0007272)3.82707995
27positive regulation of dendritic spine development (GO:0060999)3.74590324
28* amino acid import (GO:0043090)3.73238857
29neurotransmitter secretion (GO:0007269)3.72133817
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69357170
31transmission of nerve impulse (GO:0019226)3.67084250
32regulation of synaptic vesicle transport (GO:1902803)3.53370523
33dendritic spine morphogenesis (GO:0060997)3.53123247
34neuromuscular process controlling posture (GO:0050884)3.53041107
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.52489724
36regulation of glutamate receptor signaling pathway (GO:1900449)3.50365029
37negative regulation of neurotransmitter transport (GO:0051589)3.49782293
38exploration behavior (GO:0035640)3.48940590
39glutamate receptor signaling pathway (GO:0007215)3.47520860
40astrocyte differentiation (GO:0048708)3.45835934
41synaptic transmission, glutamatergic (GO:0035249)3.44777236
42cerebellar granule cell differentiation (GO:0021707)3.44590213
43* regulation of neuronal synaptic plasticity (GO:0048168)3.39567285
44layer formation in cerebral cortex (GO:0021819)3.37592720
45protein localization to synapse (GO:0035418)3.34021129
46neuronal ion channel clustering (GO:0045161)3.33822220
47regulation of ARF protein signal transduction (GO:0032012)3.33150869
48* neurotransmitter transport (GO:0006836)3.32170505
49presynaptic membrane organization (GO:0097090)3.32168430
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31976118
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30946748
52response to auditory stimulus (GO:0010996)3.30450016
53fatty acid elongation (GO:0030497)3.30233713
54astrocyte development (GO:0014002)3.29275483
55neuron-neuron synaptic transmission (GO:0007270)3.29019923
56regulation of synapse maturation (GO:0090128)3.25499693
57regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24475351
58synaptic vesicle endocytosis (GO:0048488)3.23163596
59long-term memory (GO:0007616)3.22787834
60presynaptic membrane assembly (GO:0097105)3.19474947
61regulation of dendritic spine development (GO:0060998)3.19247454
62negative regulation of neurotransmitter secretion (GO:0046929)3.19114568
63C4-dicarboxylate transport (GO:0015740)3.18656912
64dendrite morphogenesis (GO:0048813)3.18538421
65* adult walking behavior (GO:0007628)3.17412142
66auditory behavior (GO:0031223)3.16293488
67regulation of dendritic spine morphogenesis (GO:0061001)3.16141082
68long-chain fatty acid biosynthetic process (GO:0042759)3.15266263
69cerebellar Purkinje cell layer development (GO:0021680)3.13498439
70cellular sodium ion homeostasis (GO:0006883)3.12457876
71* acidic amino acid transport (GO:0015800)3.12164828
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12055814
73negative regulation of dendrite morphogenesis (GO:0050774)3.11162033
74neuromuscular process controlling balance (GO:0050885)3.10356360
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09927341
76gamma-aminobutyric acid signaling pathway (GO:0007214)3.08039194
77neurotransmitter-gated ion channel clustering (GO:0072578)3.07407706
78neuron recognition (GO:0008038)3.07018662
79* potassium ion import (GO:0010107)3.06678453
80regulation of synapse structural plasticity (GO:0051823)3.06477613
81* regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04569732
82synaptic vesicle docking involved in exocytosis (GO:0016081)3.03634031
83positive regulation of neurotransmitter secretion (GO:0001956)3.01646864
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00339909
85long-term synaptic potentiation (GO:0060291)3.00044118
86* regulation of neurotransmitter levels (GO:0001505)2.98968971
87negative regulation of protein localization to cell surface (GO:2000009)2.97708958
88positive regulation of neurotransmitter transport (GO:0051590)2.96792729
89cell communication by electrical coupling (GO:0010644)2.95654774
90positive regulation of membrane potential (GO:0045838)2.95131724
91* regulation of synaptic transmission (GO:0050804)2.94241115
92positive regulation of potassium ion transmembrane transport (GO:1901381)2.94189826
93positive regulation of potassium ion transport (GO:0043268)2.92492310
94chondroitin sulfate catabolic process (GO:0030207)2.91734044
95membrane assembly (GO:0071709)2.90849354
96regulation of female receptivity (GO:0045924)2.90782786
97cerebellar Purkinje cell differentiation (GO:0021702)2.90109887
98regulation of vesicle fusion (GO:0031338)2.89536663
99response to methylmercury (GO:0051597)2.88279671
100* neurotransmitter uptake (GO:0001504)2.85712113
101cell communication involved in cardiac conduction (GO:0086065)2.85181586
102myelin maintenance (GO:0043217)2.85027967
103* potassium ion homeostasis (GO:0055075)2.84516893
104membrane depolarization (GO:0051899)2.83901781
105regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82505071
106proline transport (GO:0015824)2.81931656
107axonal fasciculation (GO:0007413)2.80378687
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.77788449
109oligodendrocyte differentiation (GO:0048709)2.77264306
110regulation of neurotransmitter secretion (GO:0046928)2.76556957
111regulation of respiratory system process (GO:0044065)2.75893179
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75780153
113establishment of mitochondrion localization (GO:0051654)2.75384331
114* regulation of synaptic plasticity (GO:0048167)2.75146676
115regulation of voltage-gated calcium channel activity (GO:1901385)2.74893753
116regulation of neurotransmitter transport (GO:0051588)2.73911898
117negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73439877
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72745817
119cerebral cortex radially oriented cell migration (GO:0021799)2.71322724
120mechanosensory behavior (GO:0007638)2.70506757
121mating behavior (GO:0007617)2.70408360
122neurotransmitter catabolic process (GO:0042135)2.70393713
123peptidyl-tyrosine autophosphorylation (GO:0038083)2.70235337
124nerve growth factor signaling pathway (GO:0038180)2.69991212
125regulation of postsynaptic membrane potential (GO:0060078)2.69287926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73798752
2GBX2_23144817_ChIP-Seq_PC3_Human3.14071137
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97598396
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92395298
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82075354
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62708707
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62708707
8DROSHA_22980978_ChIP-Seq_HELA_Human2.52623441
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49195301
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46794789
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41915905
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41478464
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40044019
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39971548
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.29628905
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.28108730
17REST_21632747_ChIP-Seq_MESCs_Mouse2.21487803
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19474082
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.17604642
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17195744
21AR_21572438_ChIP-Seq_LNCaP_Human2.16236678
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.11215424
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.08957204
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.82353144
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.81895966
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81401071
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75982644
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72318386
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71644604
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50110893
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49557428
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.47885840
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47503548
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46074144
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45781911
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41867478
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41630852
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41234871
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40085713
40SMAD4_21799915_ChIP-Seq_A2780_Human1.37236417
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37229044
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37164343
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36343120
44TAF15_26573619_Chip-Seq_HEK293_Human1.35127822
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34867808
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33626000
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.31558012
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28700374
49* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28360515
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.26851145
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26824270
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26712969
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26062659
54* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25553936
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.22595535
56STAT3_23295773_ChIP-Seq_U87_Human1.20116589
57P300_19829295_ChIP-Seq_ESCs_Human1.19280961
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18520130
59OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15206471
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.14123648
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12001240
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.11729636
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09577868
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09020400
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.08592937
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08257307
67AR_19668381_ChIP-Seq_PC3_Human1.07113708
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06658054
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06196822
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06164063
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05698639
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04719252
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03737677
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03715483
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.03531624
76AR_25329375_ChIP-Seq_VCAP_Human1.03257309
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02892546
78TCF4_23295773_ChIP-Seq_U87_Human1.02302173
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.02171406
80* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01683241
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.01549488
82TET1_21490601_ChIP-Seq_MESCs_Mouse1.01066352
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00729136
84ER_23166858_ChIP-Seq_MCF-7_Human0.99510828
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98538654
86RXR_22108803_ChIP-Seq_LS180_Human0.97914901
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97867426
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97735340
89AHR_22903824_ChIP-Seq_MCF-7_Human0.97454918
90TP53_16413492_ChIP-PET_HCT116_Human0.95076823
91KDM2B_26808549_Chip-Seq_K562_Human0.93436064
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.91897021
93* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91142797
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.90621305
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90584158
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90379612
97CTCF_27219007_Chip-Seq_Bcells_Human0.89257791
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88352368
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.88318023
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.87514261
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.87448871
102RUNX2_22187159_ChIP-Seq_PCA_Human0.87421161
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87167655
104ZNF274_21170338_ChIP-Seq_K562_Hela0.86842557
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86738536
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85706991
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.85232549
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84647944
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84176823
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83875078
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83693215
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83332254
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83264552
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83221659
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82841359
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82664672
117RNF2_27304074_Chip-Seq_NSC_Mouse0.82653503
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82328517
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82059818
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81473758
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79680785
122OCT4_19829295_ChIP-Seq_ESCs_Human0.79362786
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77381043
124* DPY_21335234_ChIP-Seq_ESCs_Mouse0.77346440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.29153548
2MP0003880_abnormal_central_pattern4.64797677
3MP0004270_analgesia3.67099531
4* MP0003635_abnormal_synaptic_transmissio3.56075495
5MP0005423_abnormal_somatic_nervous3.48618559
6MP0009046_muscle_twitch3.19802342
7* MP0002064_seizures3.17648783
8MP0009745_abnormal_behavioral_response3.07792945
9* MP0000920_abnormal_myelination2.98832630
10* MP0001486_abnormal_startle_reflex2.84091476
11* MP0002272_abnormal_nervous_system2.81753810
12MP0002063_abnormal_learning/memory/cond2.69439570
13MP0003329_amyloid_beta_deposits2.51752595
14* MP0003690_abnormal_glial_cell2.47596779
15MP0002734_abnormal_mechanical_nocicepti2.45670624
16MP0002572_abnormal_emotion/affect_behav2.39913561
17MP0001968_abnormal_touch/_nociception2.35316653
18MP0008569_lethality_at_weaning2.25176984
19MP0004142_abnormal_muscle_tone2.09206937
20MP0001440_abnormal_grooming_behavior2.05123523
21MP0000778_abnormal_nervous_system2.04492919
22* MP0004885_abnormal_endolymph2.02457100
23* MP0002067_abnormal_sensory_capabilities1.92171296
24MP0001501_abnormal_sleep_pattern1.91469191
25* MP0003634_abnormal_glial_cell1.88147100
26MP0001970_abnormal_pain_threshold1.85659265
27MP0002733_abnormal_thermal_nociception1.81375731
28MP0004858_abnormal_nervous_system1.79737187
29MP0005646_abnormal_pituitary_gland1.75957447
30MP0002736_abnormal_nociception_after1.75557679
31MP0004742_abnormal_vestibular_system1.72397816
32* MP0003633_abnormal_nervous_system1.67593299
33* MP0000955_abnormal_spinal_cord1.64495877
34MP0001905_abnormal_dopamine_level1.61586320
35MP0004043_abnormal_pH_regulation1.60515392
36MP0009780_abnormal_chondrocyte_physiolo1.58680597
37* MP0003631_nervous_system_phenotype1.53893942
38MP0002822_catalepsy1.52803435
39MP0004924_abnormal_behavior1.52377024
40MP0005386_behavior/neurological_phenoty1.52377024
41* MP0002882_abnormal_neuron_morphology1.51058816
42* MP0002066_abnormal_motor_capabilities/c1.49405713
43MP0002557_abnormal_social/conspecific_i1.47792613
44MP0002735_abnormal_chemical_nociception1.45719793
45* MP0002229_neurodegeneration1.45056750
46MP0001529_abnormal_vocalization1.42147146
47MP0004811_abnormal_neuron_physiology1.38737769
48MP0005645_abnormal_hypothalamus_physiol1.38232324
49MP0002184_abnormal_innervation1.31675691
50* MP0003632_abnormal_nervous_system1.31308265
51MP0005171_absent_coat_pigmentation1.30788603
52MP0005623_abnormal_meninges_morphology1.25420135
53MP0000604_amyloidosis1.24772313
54MP0003136_yellow_coat_color1.24475813
55MP0001502_abnormal_circadian_rhythm1.23416706
56MP0005167_abnormal_blood-brain_barrier1.22264437
57* MP0001485_abnormal_pinna_reflex1.19473994
58MP0001299_abnormal_eye_distance/1.15617444
59MP0001177_atelectasis1.13895484
60* MP0002152_abnormal_brain_morphology1.11500747
61* MP0005551_abnormal_eye_electrophysiolog1.10920670
62* MP0001963_abnormal_hearing_physiology1.10062739
63MP0005409_darkened_coat_color1.07789726
64MP0001984_abnormal_olfaction1.02697311
65MP0003123_paternal_imprinting1.00472282
66MP0004145_abnormal_muscle_electrophysio1.00273656
67MP0002909_abnormal_adrenal_gland0.99933082
68MP0003075_altered_response_to0.99196649
69MP0001986_abnormal_taste_sensitivity0.95581965
70MP0003950_abnormal_plasma_membrane0.94926712
71MP0006276_abnormal_autonomic_nervous0.94866868
72MP0002653_abnormal_ependyma_morphology0.94234638
73* MP0002752_abnormal_somatic_nervous0.91367442
74MP0003879_abnormal_hair_cell0.89164850
75MP0005410_abnormal_fertilization0.86713620
76MP0003183_abnormal_peptide_metabolism0.86343252
77MP0002090_abnormal_vision0.85730163
78MP0000579_abnormal_nail_morphology0.85567982
79MP0003137_abnormal_impulse_conducting0.81496254
80MP0003172_abnormal_lysosome_physiology0.81242570
81MP0000566_synostosis0.79053584
82MP0008874_decreased_physiological_sensi0.75130343
83MP0002069_abnormal_eating/drinking_beha0.74263508
84MP0000747_muscle_weakness0.74257516
85MP0003787_abnormal_imprinting0.73407077
86MP0000631_abnormal_neuroendocrine_gland0.72933949
87MP0008872_abnormal_physiological_respon0.71060537
88MP0000751_myopathy0.70837062
89MP0001346_abnormal_lacrimal_gland0.70396173
90MP0004134_abnormal_chest_morphology0.65743139
91MP0004130_abnormal_muscle_cell0.65465575
92MP0001943_abnormal_respiration0.62693951
93MP0003122_maternal_imprinting0.62659158
94MP0000013_abnormal_adipose_tissue0.62613531
95MP0004147_increased_porphyrin_level0.62445180
96* MP0000026_abnormal_inner_ear0.62245893
97MP0006072_abnormal_retinal_apoptosis0.61912527
98MP0004085_abnormal_heartbeat0.61332659
99MP0005166_decreased_susceptibility_to0.58365379
100MP0003283_abnormal_digestive_organ0.57926676
101MP0005535_abnormal_body_temperature0.56348008
102MP0002638_abnormal_pupillary_reflex0.55049642
103MP0002089_abnormal_postnatal_growth/wei0.54469573
104MP0003938_abnormal_ear_development0.54353864
105MP0000462_abnormal_digestive_system0.53719619
106* MP0010769_abnormal_survival0.52436970
107MP0005195_abnormal_posterior_eye0.51934983
108MP0003861_abnormal_nervous_system0.51795082
109* MP0010768_mortality/aging0.51074951
110MP0002249_abnormal_larynx_morphology0.50336972
111* MP0003956_abnormal_body_size0.50246675
112* MP0010770_preweaning_lethality0.49292594
113* MP0002082_postnatal_lethality0.49292594
114MP0001664_abnormal_digestion0.48664942
115MP0002133_abnormal_respiratory_system0.45795559
116MP0005388_respiratory_system_phenotype0.45795559
117* MP0001731_abnormal_postnatal_growth0.44138983

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.75880147
2Focal motor seizures (HP:0011153)5.71659842
3Neurofibrillary tangles (HP:0002185)4.94849685
4Supranuclear gaze palsy (HP:0000605)4.91367460
5Action tremor (HP:0002345)4.49801535
6Focal seizures (HP:0007359)4.25062247
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.05103630
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.05103630
9Megalencephaly (HP:0001355)3.96602448
10Ankle clonus (HP:0011448)3.94002473
11Abnormality of the corticospinal tract (HP:0002492)3.77651423
12Cerebral inclusion bodies (HP:0100314)3.72560246
13Dysmetria (HP:0001310)3.72391399
14Obstructive sleep apnea (HP:0002870)3.65405513
15Progressive cerebellar ataxia (HP:0002073)3.63834117
16Epileptic encephalopathy (HP:0200134)3.49610678
17Spastic gait (HP:0002064)3.49097710
18Visual hallucinations (HP:0002367)3.46669413
19Aplasia involving bones of the extremities (HP:0009825)3.45923047
20Aplasia involving bones of the upper limbs (HP:0009823)3.45923047
21Aplasia of the phalanges of the hand (HP:0009802)3.45923047
22Insidious onset (HP:0003587)3.30355715
23Termporal pattern (HP:0011008)3.30355715
24Atonic seizures (HP:0010819)3.24453165
25Scanning speech (HP:0002168)3.22360033
26Hemiparesis (HP:0001269)3.18174346
27Generalized tonic-clonic seizures (HP:0002069)3.16701336
28Postural instability (HP:0002172)3.14547717
29Abnormality of binocular vision (HP:0011514)3.11268348
30Diplopia (HP:0000651)3.11268348
31* Intention tremor (HP:0002080)3.09590321
32Hemiplegia (HP:0002301)3.03285896
33Onion bulb formation (HP:0003383)2.94739051
34Absence seizures (HP:0002121)2.85619935
35Dialeptic seizures (HP:0011146)2.85245882
36Limb dystonia (HP:0002451)2.83426910
37Urinary bladder sphincter dysfunction (HP:0002839)2.82727334
38Urinary urgency (HP:0000012)2.74950437
39Broad-based gait (HP:0002136)2.74196802
40Lower limb muscle weakness (HP:0007340)2.73278072
41Depression (HP:0000716)2.71641191
42Slow saccadic eye movements (HP:0000514)2.71045549
43Gaze-evoked nystagmus (HP:0000640)2.69145403
44Truncal ataxia (HP:0002078)2.66521078
45Febrile seizures (HP:0002373)2.63669621
46Pheochromocytoma (HP:0002666)2.63552283
47Anxiety (HP:0000739)2.60227643
48Clumsiness (HP:0002312)2.59292232
49Mutism (HP:0002300)2.55812241
50Annular pancreas (HP:0001734)2.54828024
51Impaired vibration sensation in the lower limbs (HP:0002166)2.52593342
52Sleep apnea (HP:0010535)2.45745895
53Retinal dysplasia (HP:0007973)2.43702256
54Delusions (HP:0000746)2.42102728
55Abnormal auditory evoked potentials (HP:0006958)2.39235007
56Clonus (HP:0002169)2.38857749
57Epileptiform EEG discharges (HP:0011182)2.36950061
58Apathy (HP:0000741)2.35386909
59* Dysdiadochokinesis (HP:0002075)2.35188700
60Abnormality of saccadic eye movements (HP:0000570)2.32016208
61Poor eye contact (HP:0000817)2.30723154
62* Abnormal eating behavior (HP:0100738)2.27047204
63Alacrima (HP:0000522)2.25150898
64Hyperventilation (HP:0002883)2.22478142
65Split foot (HP:0001839)2.21136470
66Neuronal loss in central nervous system (HP:0002529)2.18658819
67Neuroendocrine neoplasm (HP:0100634)2.17707397
68Abnormal social behavior (HP:0012433)2.16841161
69Impaired social interactions (HP:0000735)2.16841161
70Craniofacial dystonia (HP:0012179)2.16826417
71Generalized myoclonic seizures (HP:0002123)2.13480867
72Rapidly progressive (HP:0003678)2.11947400
73Torticollis (HP:0000473)2.11749010
74Bronchomalacia (HP:0002780)2.11596249
75Abnormality of the periventricular white matter (HP:0002518)2.09467800
76Progressive inability to walk (HP:0002505)2.09203843
77Diminished motivation (HP:0000745)2.07274995
78Postural tremor (HP:0002174)2.06541520
79Cerebral hypomyelination (HP:0006808)2.06076528
80Genetic anticipation (HP:0003743)2.06033876
81EEG with generalized epileptiform discharges (HP:0011198)2.05893167
82Spastic tetraparesis (HP:0001285)2.05071077
83Akinesia (HP:0002304)2.04910718
84Humeroradial synostosis (HP:0003041)2.04398593
85Synostosis involving the elbow (HP:0003938)2.04398593
86Rigidity (HP:0002063)2.01888305
87Thickened helices (HP:0000391)2.00287539
88Sensory axonal neuropathy (HP:0003390)1.99822379
89Bradykinesia (HP:0002067)1.97438607
90Papilledema (HP:0001085)1.97363509
91Insomnia (HP:0100785)1.95257481
92Drooling (HP:0002307)1.92262055
93Excessive salivation (HP:0003781)1.92262055
94Decreased lacrimation (HP:0000633)1.90481640
95Hypsarrhythmia (HP:0002521)1.90436911
96Impaired vibratory sensation (HP:0002495)1.89936223
97Morphological abnormality of the pyramidal tract (HP:0002062)1.89821228
98Blue irides (HP:0000635)1.88033228
99Choreoathetosis (HP:0001266)1.87500947
100Polyphagia (HP:0002591)1.87197999
101Focal dystonia (HP:0004373)1.86860736
102Anomalous pulmonary venous return (HP:0010772)1.86852862
103Psychosis (HP:0000709)1.85337117
104Impaired smooth pursuit (HP:0007772)1.84824041
105Bundle branch block (HP:0011710)1.84806663
106Tetraplegia (HP:0002445)1.84528881
107Gait ataxia (HP:0002066)1.84400245
108Anteriorly placed anus (HP:0001545)1.84006466
109Confusion (HP:0001289)1.81718299
110Abnormal large intestine physiology (HP:0012700)1.81672939
111Turricephaly (HP:0000262)1.81304984
112Status epilepticus (HP:0002133)1.81227384
113Hammertoe (HP:0001765)1.81226545
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80556691
115Spastic paraplegia (HP:0001258)1.80359653
116Amblyopia (HP:0000646)1.80304780
117Abnormality of ocular smooth pursuit (HP:0000617)1.80214461
118Ventricular fibrillation (HP:0001663)1.79195209
119Lower limb asymmetry (HP:0100559)1.76914623
120Abnormality of the middle phalanges of the toes (HP:0010183)1.76413221
121Bowel incontinence (HP:0002607)1.75734750
122Dementia (HP:0000726)1.74718089
123Stereotypic behavior (HP:0000733)1.74630397
124CNS hypomyelination (HP:0003429)1.73816181
125Memory impairment (HP:0002354)1.73382834
126Overriding aorta (HP:0002623)1.72865553
127Abnormality of the lower motor neuron (HP:0002366)1.72799106
128Absent speech (HP:0001344)1.70920289
129Foot dorsiflexor weakness (HP:0009027)1.68391723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.35285662
2NTRK33.09600293
3EPHA43.00468595
4OXSR12.84938178
5PAK62.51709901
6TNIK2.51671424
7MAP3K92.51432566
8NTRK22.42178544
9MARK12.34876333
10NTRK12.17029694
11MAP3K42.08024233
12PRKD31.96841742
13WNK11.95964565
14MINK11.94787172
15UHMK11.88950344
16CDK191.84507029
17SGK2231.66302723
18SGK4941.66302723
19MAP2K71.63506755
20RIPK11.59524564
21TYRO31.58015418
22PRPF4B1.56955421
23PHKG11.50834445
24PHKG21.50834445
25WNK41.49923219
26MAPKAPK51.49119349
27CDK51.47652979
28EPHB11.46974751
29PNCK1.46722172
30CASK1.44978587
31FGFR21.44720632
32PKN11.42261685
33KSR21.39110317
34NEK61.38700148
35LMTK21.32751088
36CAMKK11.28580412
37PINK11.27497797
38DAPK21.26163188
39ROCK21.24535424
40MAP2K41.22569572
41CAMK2B1.20929114
42FES1.17265541
43MAPK131.17031456
44LATS21.10640894
45SIK21.08983579
46STK381.07890944
47PRKCH1.06140080
48PAK31.04747047
49BCR1.00931781
50LIMK10.99898292
51CAMK2A0.98232474
52CAMK2D0.97277569
53CAMK2G0.95798717
54CDK140.92949451
55CDK150.92917946
56PRKCG0.92518479
57STK110.92380058
58CDK180.88791406
59CSNK1G20.88532874
60GRK50.88005935
61MAPK120.84889984
62MAP3K130.84110683
63PLK20.82934490
64CDK11A0.80993863
65ARAF0.79956098
66DAPK10.79637484
67MUSK0.78979848
68ICK0.77042909
69FGR0.76893242
70MARK20.76158635
71TNK20.73519567
72PDPK10.72559630
73MAP3K20.72342828
74SGK30.71805915
75SGK20.70748518
76CSNK1A1L0.70581918
77RIPK40.70269537
78MAP3K120.69147132
79CAMK1G0.66820666
80CAMK10.66285885
81CSNK1G30.65804918
82SGK10.65729516
83ALK0.65563172
84PRKCE0.61182575
85FYN0.61051229
86PRKD10.60886190
87RET0.60426782
88BRSK10.60351344
89KSR10.59543371
90IRAK20.59523850
91PDGFRA0.59346364
92DYRK1A0.59281111
93CAMK40.58859917
94CAMKK20.58094762
95ROCK10.58017902
96PDK10.57615443
97DDR20.54329437
98PRKCQ0.54096845
99WNK30.53067319
100MAPK100.52113418
101BMX0.51859285
102CDC42BPA0.51133689
103MET0.50640880
104ERBB20.50632906
105BMPR20.49011539
106RPS6KA30.48662034
107RAF10.45488888
108CSNK1G10.44376524
109PRKG10.42238881
110PRKCZ0.40540574
111DMPK0.39447894
112FGFR30.36648862
113CSNK1D0.33169215
114PDGFRB0.33079039
115RPS6KB10.32976264
116PRKCA0.32209071
117JAK20.31441784
118PIK3CA0.30385507
119MAPK40.30314711
120DAPK30.29898783
121SRC0.28210092

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.05427286
2Nicotine addiction_Homo sapiens_hsa050332.95269809
3GABAergic synapse_Homo sapiens_hsa047272.78124923
4Synaptic vesicle cycle_Homo sapiens_hsa047212.52607950
5Glutamatergic synapse_Homo sapiens_hsa047242.50130652
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20396027
7Morphine addiction_Homo sapiens_hsa050322.16247129
8Circadian entrainment_Homo sapiens_hsa047132.14566705
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04874530
10Salivary secretion_Homo sapiens_hsa049702.01982025
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99993442
12Olfactory transduction_Homo sapiens_hsa047401.92162760
13Long-term potentiation_Homo sapiens_hsa047201.77598780
14* Gastric acid secretion_Homo sapiens_hsa049711.75226810
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64261691
16Amphetamine addiction_Homo sapiens_hsa050311.63751366
17Insulin secretion_Homo sapiens_hsa049111.63412403
18Dopaminergic synapse_Homo sapiens_hsa047281.61408190
19Long-term depression_Homo sapiens_hsa047301.56107524
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54949365
21Cholinergic synapse_Homo sapiens_hsa047251.50178308
22Serotonergic synapse_Homo sapiens_hsa047261.46948796
23Cocaine addiction_Homo sapiens_hsa050301.45145001
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39414174
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37412157
26Histidine metabolism_Homo sapiens_hsa003401.35949417
27Steroid biosynthesis_Homo sapiens_hsa001001.34797797
28Taste transduction_Homo sapiens_hsa047421.33147635
29Renin secretion_Homo sapiens_hsa049241.30708613
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30494567
31Axon guidance_Homo sapiens_hsa043601.30269231
32Fatty acid elongation_Homo sapiens_hsa000621.29697626
33Ether lipid metabolism_Homo sapiens_hsa005651.26825647
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24665905
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23555165
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23340371
37Fatty acid biosynthesis_Homo sapiens_hsa000611.18278283
38cAMP signaling pathway_Homo sapiens_hsa040241.14468857
39Calcium signaling pathway_Homo sapiens_hsa040201.13617064
40Dorso-ventral axis formation_Homo sapiens_hsa043201.10887882
41Oxytocin signaling pathway_Homo sapiens_hsa049211.10182704
42Gap junction_Homo sapiens_hsa045401.09372463
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07392722
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02726775
45Collecting duct acid secretion_Homo sapiens_hsa049661.02228780
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02223695
47Pancreatic secretion_Homo sapiens_hsa049721.02211981
48GnRH signaling pathway_Homo sapiens_hsa049121.02102305
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.00845874
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98492105
51beta-Alanine metabolism_Homo sapiens_hsa004100.97274726
52Bile secretion_Homo sapiens_hsa049760.92906335
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92234316
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90832122
55Cardiac muscle contraction_Homo sapiens_hsa042600.90462255
56Butanoate metabolism_Homo sapiens_hsa006500.90232902
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89336293
58ErbB signaling pathway_Homo sapiens_hsa040120.88176398
59Arginine and proline metabolism_Homo sapiens_hsa003300.86886726
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.80430944
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79711506
62Estrogen signaling pathway_Homo sapiens_hsa049150.79113038
63Melanogenesis_Homo sapiens_hsa049160.78871505
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.77231000
65Thyroid hormone synthesis_Homo sapiens_hsa049180.76429851
66Vitamin B6 metabolism_Homo sapiens_hsa007500.76169405
67Type II diabetes mellitus_Homo sapiens_hsa049300.75773510
68Mineral absorption_Homo sapiens_hsa049780.73318928
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72025668
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.71545254
71Vibrio cholerae infection_Homo sapiens_hsa051100.70911657
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70585651
73Choline metabolism in cancer_Homo sapiens_hsa052310.69598005
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69169385
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69119484
76Glioma_Homo sapiens_hsa052140.68257560
77Renal cell carcinoma_Homo sapiens_hsa052110.67887848
78Oocyte meiosis_Homo sapiens_hsa041140.67421876
79Endocytosis_Homo sapiens_hsa041440.67080002
80Ras signaling pathway_Homo sapiens_hsa040140.65467860
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61286456
82Circadian rhythm_Homo sapiens_hsa047100.61265387
83Dilated cardiomyopathy_Homo sapiens_hsa054140.60569079
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60245535
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.59936109
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59558426
87Sphingolipid metabolism_Homo sapiens_hsa006000.58751848
88VEGF signaling pathway_Homo sapiens_hsa043700.56724499
89Ovarian steroidogenesis_Homo sapiens_hsa049130.56583427
90MAPK signaling pathway_Homo sapiens_hsa040100.55647552
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54192490
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52515140
93Phototransduction_Homo sapiens_hsa047440.50985030
94Fatty acid metabolism_Homo sapiens_hsa012120.49991395
95Glucagon signaling pathway_Homo sapiens_hsa049220.48806839
96Tight junction_Homo sapiens_hsa045300.47997882
97Rap1 signaling pathway_Homo sapiens_hsa040150.45941293
98Prion diseases_Homo sapiens_hsa050200.45322744
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43481799
100PPAR signaling pathway_Homo sapiens_hsa033200.42933442
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41711875
102Inositol phosphate metabolism_Homo sapiens_hsa005620.41335286
103Endometrial cancer_Homo sapiens_hsa052130.39556800
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37689872
105Hedgehog signaling pathway_Homo sapiens_hsa043400.37533998
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36050894
107Arginine biosynthesis_Homo sapiens_hsa002200.34650737
108Lysosome_Homo sapiens_hsa041420.34594519
109Alcoholism_Homo sapiens_hsa050340.32991555
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32651725
111mTOR signaling pathway_Homo sapiens_hsa041500.30411721
112Wnt signaling pathway_Homo sapiens_hsa043100.29750957
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29565452
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28555762
115Sulfur metabolism_Homo sapiens_hsa009200.28532928
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28470936
117Chemokine signaling pathway_Homo sapiens_hsa040620.28074319
118Hippo signaling pathway_Homo sapiens_hsa043900.27160494
119AMPK signaling pathway_Homo sapiens_hsa041520.24846459
120ABC transporters_Homo sapiens_hsa020100.23355005

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