KCNJ11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.55490214
2cardiac myofibril assembly (GO:0055003)5.88501194
3myofibril assembly (GO:0030239)5.59852611
4sarcoplasmic reticulum calcium ion transport (GO:0070296)5.57156936
5negative regulation of potassium ion transmembrane transport (GO:1901380)5.52334501
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.45137257
7plasma membrane repair (GO:0001778)5.42167675
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.41620192
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.34269833
10actin-myosin filament sliding (GO:0033275)5.33600831
11muscle filament sliding (GO:0030049)5.33600831
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.21928004
13cardiac muscle contraction (GO:0060048)5.12314784
14regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.82823970
15regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.80786176
16response to muscle activity (GO:0014850)4.76003751
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.74155081
18regulation of skeletal muscle contraction (GO:0014819)4.64037151
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.59943809
20tricarboxylic acid cycle (GO:0006099)4.59033522
21detection of calcium ion (GO:0005513)4.58792923
22skeletal muscle fiber development (GO:0048741)4.41982781
23actin-mediated cell contraction (GO:0070252)4.38554914
24regulation of membrane repolarization (GO:0060306)4.38492598
25regulation of actin filament-based movement (GO:1903115)4.36349942
26striated muscle contraction (GO:0006941)4.34395917
27neuronal action potential propagation (GO:0019227)4.28127421
28myotube cell development (GO:0014904)4.26953413
29ventricular cardiac muscle cell action potential (GO:0086005)4.25497920
30actomyosin structure organization (GO:0031032)4.25280166
31glycogen catabolic process (GO:0005980)4.19409674
32regulation of cell communication by electrical coupling (GO:0010649)4.17132320
33cardiac muscle cell development (GO:0055013)4.08823257
34cell communication involved in cardiac conduction (GO:0086065)4.07614143
35cell communication by electrical coupling (GO:0010644)4.07321891
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.04025823
37regulation of relaxation of muscle (GO:1901077)3.98635775
38glucan catabolic process (GO:0009251)3.84572384
39regulation of striated muscle contraction (GO:0006942)3.81479680
40carnitine shuttle (GO:0006853)3.81196602
41cardiac muscle hypertrophy (GO:0003300)3.81148104
42relaxation of cardiac muscle (GO:0055119)3.80777666
43cardiac cell development (GO:0055006)3.78791245
44adult heart development (GO:0007512)3.78232688
45regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.76410270
46glycogen biosynthetic process (GO:0005978)3.74350227
47glucan biosynthetic process (GO:0009250)3.74350227
48muscle fiber development (GO:0048747)3.73057950
49striated muscle hypertrophy (GO:0014897)3.67017735
50positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.65614768
51membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.61856131
52regulation of calcium ion transmembrane transporter activity (GO:1901019)3.61458153
53regulation of calcium ion transmembrane transport (GO:1903169)3.61458153
54regulation of sarcomere organization (GO:0060297)3.57899891
55regulation of glucokinase activity (GO:0033131)3.56091298
56regulation of hexokinase activity (GO:1903299)3.56091298
57cellular polysaccharide catabolic process (GO:0044247)3.55119944
58regulation of acyl-CoA biosynthetic process (GO:0050812)3.53090316
59neuromuscular synaptic transmission (GO:0007274)3.51164819
60heart process (GO:0003015)3.50924057
61heart contraction (GO:0060047)3.50924057
62cardiac muscle tissue morphogenesis (GO:0055008)3.49006226
63regulation of the force of heart contraction (GO:0002026)3.48701173
64heart trabecula formation (GO:0060347)3.46852482
65cardiac conduction (GO:0061337)3.46070242
66NADH metabolic process (GO:0006734)3.44370786
67negative regulation of potassium ion transport (GO:0043267)3.44311857
68skeletal muscle contraction (GO:0003009)3.41847049
69muscle cell cellular homeostasis (GO:0046716)3.41794107
70neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.35023405
71response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.34362335
72regulation of heart rate by cardiac conduction (GO:0086091)3.32502502
73bundle of His cell to Purkinje myocyte communication (GO:0086069)3.31473677
74cardiac muscle cell action potential involved in contraction (GO:0086002)3.29620581
75striated muscle adaptation (GO:0014888)3.26512243
76actin filament-based movement (GO:0030048)3.25146914
77cardiac muscle cell action potential (GO:0086001)3.24809310
78ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.23875438
79regulation of heart rate (GO:0002027)3.23473159
80Golgi transport vesicle coating (GO:0048200)3.23300969
81COPI coating of Golgi vesicle (GO:0048205)3.23300969
82membrane repolarization during action potential (GO:0086011)3.20510977
83regulation of cardiac muscle contraction (GO:0055117)3.20209522
84regulation of cofactor metabolic process (GO:0051193)3.19414937
85regulation of coenzyme metabolic process (GO:0051196)3.19414937
86polysaccharide catabolic process (GO:0000272)3.16445681
87ubiquinone biosynthetic process (GO:0006744)3.15937176
88muscle tissue morphogenesis (GO:0060415)3.14979618
89creatine metabolic process (GO:0006600)3.14088450
90muscle hypertrophy (GO:0014896)3.13900972
91fatty acid transmembrane transport (GO:1902001)3.10003925
92skeletal muscle tissue development (GO:0007519)3.08487773
93activation of protein kinase A activity (GO:0034199)3.08052647
94gluconeogenesis (GO:0006094)3.06456275
95regulation of heart contraction (GO:0008016)3.05353816
96negative regulation of calcium ion transmembrane transport (GO:1903170)3.05282034
97negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.05282034
98synaptic vesicle docking involved in exocytosis (GO:0016081)3.05207873
99positive regulation of potassium ion transmembrane transport (GO:1901381)3.05200539
100positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02458253
101growth hormone secretion (GO:0030252)3.02020909
102negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01441903
103muscle contraction (GO:0006936)3.00019690
104regulation of cardiac muscle cell contraction (GO:0086004)2.99101971
105glycogen metabolic process (GO:0005977)2.99012300
106fructose metabolic process (GO:0006000)2.97911616
107cardiac muscle hypertrophy in response to stress (GO:0014898)2.97125062
108muscle hypertrophy in response to stress (GO:0003299)2.97125062
109cardiac muscle adaptation (GO:0014887)2.97125062
110calcium ion import (GO:0070509)2.95062704
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93250837
112response to inactivity (GO:0014854)2.91765984
113regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90927138
114regulation of sodium ion transmembrane transporter activity (GO:2000649)2.90181358
115cellular glucan metabolic process (GO:0006073)2.89987114
116glucan metabolic process (GO:0044042)2.89987114
117positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.89413448
118relaxation of muscle (GO:0090075)2.87433492
119succinate metabolic process (GO:0006105)2.87053587
120regulation of ATPase activity (GO:0043462)2.86848032
121regulation of ATP catabolic process (GO:1903289)2.86848032
122* positive regulation of cation channel activity (GO:2001259)2.85166645
123membrane repolarization (GO:0086009)2.84757483
124regulation of sodium ion transmembrane transport (GO:1902305)2.84388506
125positive regulation of potassium ion transport (GO:0043268)2.83834961
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83460611
127regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.82814390
128muscle system process (GO:0003012)2.82506407
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82373570
130regulation of short-term neuronal synaptic plasticity (GO:0048172)2.82102990
131positive regulation of heart rate (GO:0010460)2.81975133
132muscle organ development (GO:0007517)2.81394166
133skeletal muscle adaptation (GO:0043501)2.81380649
134muscle structure development (GO:0061061)2.81245893
135aspartate family amino acid catabolic process (GO:0009068)2.80983882
136synaptic vesicle maturation (GO:0016188)2.79238293
137striated muscle cell development (GO:0055002)2.78719788
138ubiquinone metabolic process (GO:0006743)2.77929330
139membrane depolarization during action potential (GO:0086010)2.77465932
140hexose biosynthetic process (GO:0019319)2.73603638
141positive regulation of sodium ion transport (GO:0010765)2.72484835
142positive regulation of sodium ion transmembrane transport (GO:1902307)2.72004886
1432-oxoglutarate metabolic process (GO:0006103)2.71555675
144proline transport (GO:0015824)2.68920754
145muscle cell fate commitment (GO:0042693)2.65216213
146muscle organ morphogenesis (GO:0048644)2.61045427
147positive regulation of synapse maturation (GO:0090129)2.60212629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90925714
2EP300_21415370_ChIP-Seq_HL-1_Mouse2.77499480
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.73549811
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61040276
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55378006
6DROSHA_22980978_ChIP-Seq_HELA_Human2.49643779
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.20389411
8* TBX20_22080862_ChIP-Seq_HEART_Mouse2.19450648
9* TBX20_22328084_ChIP-Seq_HEART_Mouse2.19450648
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14887136
11IGF1R_20145208_ChIP-Seq_DFB_Human2.12849587
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07661080
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.03832378
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97582814
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92344145
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91555364
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88703090
18REST_21632747_ChIP-Seq_MESCs_Mouse1.86800161
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85376780
20GATA1_22025678_ChIP-Seq_K562_Human1.82460666
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.80521765
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.80145543
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.78968217
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74398641
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74398641
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74009017
27GBX2_23144817_ChIP-Seq_PC3_Human1.71716433
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.71688080
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68188242
30ZNF274_21170338_ChIP-Seq_K562_Hela1.67492012
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66080318
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65056231
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.63597583
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63449365
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54965609
36MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.54578593
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53995886
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53102133
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53092079
40* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52300256
41HTT_18923047_ChIP-ChIP_STHdh_Human1.51165375
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48242606
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45646859
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43564289
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.40251877
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38078314
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.36141503
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35212070
49ZNF263_19887448_ChIP-Seq_K562_Human1.32254840
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29169261
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.28305604
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27402282
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25240274
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23919399
55* CTCF_27219007_Chip-Seq_Bcells_Human1.23736047
56SMAD4_21799915_ChIP-Seq_A2780_Human1.22307982
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21544372
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20982186
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.20937608
60ER_23166858_ChIP-Seq_MCF-7_Human1.20317404
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20181283
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18892577
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18648521
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18273417
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14619507
66KDM2B_26808549_Chip-Seq_K562_Human1.11757055
67AR_19668381_ChIP-Seq_PC3_Human1.11673770
68* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09465571
69CBP_20019798_ChIP-Seq_JUKART_Human1.09189773
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09189773
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06796882
72AR_21572438_ChIP-Seq_LNCaP_Human1.06365391
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05298084
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04693677
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04302348
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02884900
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02871362
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02813110
79* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02672439
80SMAD4_21741376_ChIP-Seq_HESCs_Human1.02591452
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02501807
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02152785
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02067478
84RNF2_27304074_Chip-Seq_NSC_Mouse1.01736521
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01350732
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00679563
87SOX2_19829295_ChIP-Seq_ESCs_Human0.98503500
88NANOG_19829295_ChIP-Seq_ESCs_Human0.98503500
89* TP53_22573176_ChIP-Seq_HFKS_Human0.98378779
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97688637
91ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97627885
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97606702
93AR_25329375_ChIP-Seq_VCAP_Human0.97230314
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.97132358
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97059539
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96847277
97STAT3_23295773_ChIP-Seq_U87_Human0.96438388
98GATA1_19941826_ChIP-Seq_K562_Human0.96377718
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95715447
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95521712
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.95405167
102FLI1_21867929_ChIP-Seq_TH2_Mouse0.95223372
103* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94821548
104P300_19829295_ChIP-Seq_ESCs_Human0.93850080
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93792117
106BCAT_22108803_ChIP-Seq_LS180_Human0.91835992
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91499788
108CRX_20693478_ChIP-Seq_RETINA_Mouse0.90868469
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90258333
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89890195
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89871456
112SMAD4_21741376_ChIP-Seq_EPCs_Human0.89806225
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89712583
114FOXH1_21741376_ChIP-Seq_ESCs_Human0.89681135
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89579903
116TAF15_26573619_Chip-Seq_HEK293_Human0.88824967
117* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88680376
118HOXB7_26014856_ChIP-Seq_BT474_Human0.88609541
119* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88357144
120KLF4_19829295_ChIP-Seq_ESCs_Human0.88182075
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88125726
122NCOR_22424771_ChIP-Seq_293T_Human0.87812774
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87194741
124AHR_22903824_ChIP-Seq_MCF-7_Human0.86845623
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86687008
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85593323
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.85313523
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85256238
129TCF4_23295773_ChIP-Seq_U87_Human0.85180017
130* LXR_22292898_ChIP-Seq_THP-1_Human0.84948826
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.84510087
132MYC_19829295_ChIP-Seq_ESCs_Human0.84143583
133VDR_22108803_ChIP-Seq_LS180_Human0.84104541
134* CBP_21632823_ChIP-Seq_H3396_Human0.83958412
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.83662866
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83541104
137TP63_22573176_ChIP-Seq_HFKS_Human0.83515371
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83272421
139* FOXA2_19822575_ChIP-Seq_HepG2_Human0.82261496
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82150779
141GATA4_21415370_ChIP-Seq_HL-1_Mouse0.81341709
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.80703063
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80597875
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80118034
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79165179
146OCT4_20526341_ChIP-Seq_ESCs_Human0.79159486
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.79111975
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78683351
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.78533295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.63132549
2MP0003646_muscle_fatigue4.73276777
3MP0000751_myopathy4.51140483
4MP0004084_abnormal_cardiac_muscle4.30863239
5MP0004215_abnormal_myocardial_fiber3.85394563
6MP0004036_abnormal_muscle_relaxation3.85152075
7MP0000749_muscle_degeneration3.62116879
8MP0004145_abnormal_muscle_electrophysio3.35157077
9MP0005330_cardiomyopathy2.82329432
10MP0004087_abnormal_muscle_fiber2.53406632
11MP0002909_abnormal_adrenal_gland2.51689464
12MP0002972_abnormal_cardiac_muscle2.44226831
13MP0005620_abnormal_muscle_contractility2.41145301
14MP0003137_abnormal_impulse_conducting2.33297306
15MP0002106_abnormal_muscle_physiology2.31831774
16MP0004130_abnormal_muscle_cell2.31210444
17MP0002269_muscular_atrophy2.27813086
18MP0000013_abnormal_adipose_tissue2.22841149
19MP0000747_muscle_weakness2.15268717
20MP0009780_abnormal_chondrocyte_physiolo2.13680849
21MP0000750_abnormal_muscle_regeneration2.03303012
22MP0008775_abnormal_heart_ventricle2.03227604
23MP0004043_abnormal_pH_regulation2.02135988
24MP0004085_abnormal_heartbeat1.99016365
25MP0004484_altered_response_of1.95866025
26MP0005369_muscle_phenotype1.94245381
27MP0000759_abnormal_skeletal_muscle1.91346082
28MP0004859_abnormal_synaptic_plasticity1.90139155
29MP0005451_abnormal_body_composition1.80661869
30MP0001544_abnormal_cardiovascular_syste1.80147848
31MP0005385_cardiovascular_system_phenoty1.80147848
32MP0004233_abnormal_muscle_weight1.79549433
33MP0010630_abnormal_cardiac_muscle1.74301594
34MP0002877_abnormal_melanocyte_morpholog1.73819565
35MP0003787_abnormal_imprinting1.73613644
36MP0003283_abnormal_digestive_organ1.70291886
37MP0006138_congestive_heart_failure1.67485856
38MP0004270_analgesia1.65672344
39MP0002234_abnormal_pharynx_morphology1.62802867
40MP0004510_myositis1.56652577
41MP0006036_abnormal_mitochondrial_physio1.44342881
42* MP0002693_abnormal_pancreas_physiology1.41128162
43MP0003195_calcinosis1.33971349
44MP0000003_abnormal_adipose_tissue1.28714039
45MP0005423_abnormal_somatic_nervous1.27973857
46MP0003635_abnormal_synaptic_transmissio1.27264976
47MP0003123_paternal_imprinting1.27133966
48MP0003221_abnormal_cardiomyocyte_apopto1.25737417
49* MP0002078_abnormal_glucose_homeostasis1.24830450
50MP0002822_catalepsy1.22001285
51MP0008961_abnormal_basal_metabolism1.21827978
52MP0002127_abnormal_cardiovascular_syste1.21238030
53MP0000733_abnormal_muscle_development1.19466927
54MP0003828_pulmonary_edema1.18399236
55MP0001984_abnormal_olfaction1.17603416
56MP0001944_abnormal_pancreas_morphology1.15366715
57MP0005375_adipose_tissue_phenotype1.12382237
58MP0005666_abnormal_adipose_tissue1.11237085
59MP0001502_abnormal_circadian_rhythm1.09838377
60MP0001529_abnormal_vocalization1.09336934
61MP0001486_abnormal_startle_reflex1.05504580
62MP0005670_abnormal_white_adipose1.05395011
63MP0002332_abnormal_exercise_endurance1.04883521
64MP0004147_increased_porphyrin_level1.04156210
65MP0008877_abnormal_DNA_methylation1.02087985
66MP0001501_abnormal_sleep_pattern0.96963606
67MP0004142_abnormal_muscle_tone0.95009308
68MP0006276_abnormal_autonomic_nervous0.93471188
69MP0008569_lethality_at_weaning0.91835225
70MP0000678_abnormal_parathyroid_gland0.91229585
71MP0005535_abnormal_body_temperature0.91001515
72MP0009745_abnormal_behavioral_response0.90758695
73MP0004185_abnormal_adipocyte_glucose0.90018828
74MP0002108_abnormal_muscle_morphology0.88670447
75MP0003880_abnormal_central_pattern0.87830464
76MP0001661_extended_life_span0.87404582
77MP0002063_abnormal_learning/memory/cond0.86780619
78* MP0000230_abnormal_systemic_arterial0.84319430
79MP0005646_abnormal_pituitary_gland0.83753135
80MP0002734_abnormal_mechanical_nocicepti0.82976602
81MP0010386_abnormal_urinary_bladder0.82493886
82MP0002064_seizures0.82362317
83MP0002876_abnormal_thyroid_physiology0.82307661
84* MP0002272_abnormal_nervous_system0.79772991
85MP0001968_abnormal_touch/_nociception0.78235869
86MP0004924_abnormal_behavior0.77825617
87MP0005386_behavior/neurological_phenoty0.77825617
88MP0000266_abnormal_heart_morphology0.76901300
89MP0000372_irregular_coat_pigmentation0.76773857
90MP0005187_abnormal_penis_morphology0.76162124
91MP0005551_abnormal_eye_electrophysiolog0.76129180
92MP0008872_abnormal_physiological_respon0.76032317
93MP0009046_muscle_twitch0.75219964
94MP0005165_increased_susceptibility_to0.74696917
95MP0002572_abnormal_emotion/affect_behav0.74042738
96MP0006072_abnormal_retinal_apoptosis0.73792029
97MP0001765_abnormal_ion_homeostasis0.73149366
98MP0003122_maternal_imprinting0.70115962
99MP0006035_abnormal_mitochondrial_morpho0.69597728
100MP0002557_abnormal_social/conspecific_i0.68520725
101MP0005332_abnormal_amino_acid0.68220183
102MP0003183_abnormal_peptide_metabolism0.65463195
103MP0002229_neurodegeneration0.64704503
104MP0005266_abnormal_metabolism0.64702364
105MP0005167_abnormal_blood-brain_barrier0.64556042
106MP0005083_abnormal_biliary_tract0.64079689
107MP0004885_abnormal_endolymph0.63398309
108MP0003045_fibrosis0.62666486
109* MP0003953_abnormal_hormone_level0.61157270
110MP0005379_endocrine/exocrine_gland_phen0.60420711
111MP0002067_abnormal_sensory_capabilities0.59727841
112MP0003879_abnormal_hair_cell0.59234237
113MP0001440_abnormal_grooming_behavior0.57994730
114MP0002896_abnormal_bone_mineralization0.57016931
115MP0001970_abnormal_pain_threshold0.55548535
116MP0002971_abnormal_brown_adipose0.53340079
117MP0003633_abnormal_nervous_system0.53015118
118MP0001299_abnormal_eye_distance/0.52918520
119MP0002733_abnormal_thermal_nociception0.51084456
120MP0004858_abnormal_nervous_system0.50779158
121MP0002066_abnormal_motor_capabilities/c0.50649020
122MP0002638_abnormal_pupillary_reflex0.49528746
123MP0002735_abnormal_chemical_nociception0.49503148
124MP0005645_abnormal_hypothalamus_physiol0.49431836
125MP0005448_abnormal_energy_balance0.49365871
126MP0003329_amyloid_beta_deposits0.48420590

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.54563071
2Exercise-induced myalgia (HP:0003738)6.26554100
3Calf muscle hypertrophy (HP:0008981)5.86148728
4Muscle hypertrophy of the lower extremities (HP:0008968)5.65669058
5Exercise-induced muscle cramps (HP:0003710)5.53560426
6Ventricular tachycardia (HP:0004756)5.05885290
7Myoglobinuria (HP:0002913)4.85735109
8Bundle branch block (HP:0011710)4.68476202
9Atrial fibrillation (HP:0005110)4.66328390
10Muscle fiber splitting (HP:0003555)4.58500414
11Abnormality of the left ventricular outflow tract (HP:0011103)4.54688719
12Subaortic stenosis (HP:0001682)4.54688719
13Abnormality of the calf musculature (HP:0001430)4.52719927
14Hyporeflexia of lower limbs (HP:0002600)4.38690368
15Primary atrial arrhythmia (HP:0001692)4.37784676
16Supraventricular tachycardia (HP:0004755)4.17897582
17Syncope (HP:0001279)4.15259686
18Prolonged QT interval (HP:0001657)4.13300975
19Round ear (HP:0100830)4.11186171
20Supraventricular arrhythmia (HP:0005115)4.08210612
21Asymmetric septal hypertrophy (HP:0001670)3.93478812
22EMG: myopathic abnormalities (HP:0003458)3.80475917
23Hypoglycemic coma (HP:0001325)3.80400153
24Ventricular fibrillation (HP:0001663)3.80226950
25Palpitations (HP:0001962)3.70344601
26Lipoatrophy (HP:0100578)3.67553241
27Myotonia (HP:0002486)3.57492324
28Difficulty running (HP:0009046)3.56621581
29Centrally nucleated skeletal muscle fibers (HP:0003687)3.51739796
30Heart block (HP:0012722)3.47720091
31Ulnar deviation of the wrist (HP:0003049)3.45740059
32Right ventricular cardiomyopathy (HP:0011663)3.41491199
33Ventricular arrhythmia (HP:0004308)3.40533092
34Dilated cardiomyopathy (HP:0001644)3.31381480
35Frequent falls (HP:0002359)3.28656849
36Abnormal atrioventricular conduction (HP:0005150)3.24485101
37Abnormal EKG (HP:0003115)3.19646162
38Atrioventricular block (HP:0001678)3.14516127
39Increased connective tissue (HP:0009025)3.13312758
40Rhabdomyolysis (HP:0003201)3.08728038
41Hypoglycemic seizures (HP:0002173)3.04847855
42Absent phalangeal crease (HP:0006109)3.01581479
43Muscle fiber inclusion bodies (HP:0100299)3.00527011
44Calcaneovalgus deformity (HP:0001848)2.99460103
45* Hyperinsulinemic hypoglycemia (HP:0000825)2.99298617
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.94961140
47Left ventricular hypertrophy (HP:0001712)2.92906571
48Pheochromocytoma (HP:0002666)2.90261170
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.88482793
50* Ketoacidosis (HP:0001993)2.87564717
51Fetal akinesia sequence (HP:0001989)2.84266250
52Type 1 muscle fiber predominance (HP:0003803)2.76067258
53Deformed tarsal bones (HP:0008119)2.70786190
54Difficulty climbing stairs (HP:0003551)2.69720673
55Malignant hyperthermia (HP:0002047)2.66623276
56Muscle stiffness (HP:0003552)2.66304272
57Increased variability in muscle fiber diameter (HP:0003557)2.61413992
58Late onset (HP:0003584)2.52136876
59Symptomatic seizures (HP:0011145)2.51759812
60Neuroendocrine neoplasm (HP:0100634)2.50932039
61Testicular atrophy (HP:0000029)2.45678969
62Abnormal finger flexion creases (HP:0006143)2.43329616
63Generalized muscle weakness (HP:0003324)2.42160261
64Abnormality of skeletal muscle fiber size (HP:0012084)2.39706033
65EMG: neuropathic changes (HP:0003445)2.37760904
66Visual hallucinations (HP:0002367)2.32678635
67Abnormal mitochondria in muscle tissue (HP:0008316)2.32146416
68Neck muscle weakness (HP:0000467)2.30802375
69Mildly elevated creatine phosphokinase (HP:0008180)2.27169764
70Nemaline bodies (HP:0003798)2.25273654
71* Hyperglycemia (HP:0003074)2.24924702
72Hyperkalemia (HP:0002153)2.24464193
73Acute necrotizing encephalopathy (HP:0006965)2.23210282
74Focal motor seizures (HP:0011153)2.22473729
75Dysmetric saccades (HP:0000641)2.21974308
76Decreased circulating renin level (HP:0003351)2.20587390
77Limb-girdle muscle atrophy (HP:0003797)2.14349237
78Areflexia of lower limbs (HP:0002522)2.11530092
79Hepatic necrosis (HP:0002605)2.11467952
80Bulbar palsy (HP:0001283)2.10327940
81Weak cry (HP:0001612)2.09769575
82Myopathic facies (HP:0002058)2.09255957
83* Insulin-resistant diabetes mellitus (HP:0000831)2.09246633
84Abnormality of the neuromuscular junction (HP:0003398)2.07257304
85Fatigable weakness (HP:0003473)2.07257304
86Rimmed vacuoles (HP:0003805)2.05350654
87* Large for gestational age (HP:0001520)2.02057511
88Proximal amyotrophy (HP:0007126)2.00788292
89Central scotoma (HP:0000603)2.00019075
90Distal lower limb muscle weakness (HP:0009053)1.93282297
91Exercise intolerance (HP:0003546)1.91276883
92Hypoplastic ischia (HP:0003175)1.90596641
93Progressive macrocephaly (HP:0004481)1.88717211
94Tinnitus (HP:0000360)1.88240446
95Gowers sign (HP:0003391)1.87931541
96Acute encephalopathy (HP:0006846)1.86943936
97Progressive muscle weakness (HP:0003323)1.85812331
98Palmoplantar keratoderma (HP:0000982)1.84526353
99Hamartoma of the eye (HP:0010568)1.84352850
100Slender build (HP:0001533)1.81233977
101Generalized aminoaciduria (HP:0002909)1.80012442
102Scapular winging (HP:0003691)1.79135547
103Distal lower limb amyotrophy (HP:0008944)1.78551744
104Muscular dystrophy (HP:0003560)1.78361045
105* Ketosis (HP:0001946)1.78262828
106Generalized tonic-clonic seizures (HP:0002069)1.75743567
107Hip contracture (HP:0003273)1.75473133
108Hyperphosphatemia (HP:0002905)1.75267993
109Hypokalemia (HP:0002900)1.73443289
110Febrile seizures (HP:0002373)1.72058616
111Nonprogressive disorder (HP:0003680)1.71539936
112Athetosis (HP:0002305)1.70710511
113Neoplasm of the adrenal gland (HP:0100631)1.70704183
114Conjunctival hamartoma (HP:0100780)1.70431744
115Waddling gait (HP:0002515)1.70018421
116Anxiety (HP:0000739)1.69943412
117Rapidly progressive (HP:0003678)1.69671114
118Sudden cardiac death (HP:0001645)1.69475738
119Abnormality of the ischium (HP:0003174)1.68810994
120Congestive heart failure (HP:0001635)1.67460200
121Abnormality of potassium homeostasis (HP:0011042)1.66710372
122Distal arthrogryposis (HP:0005684)1.66703124
123Ragged-red muscle fibers (HP:0003200)1.66542907
124Hepatocellular necrosis (HP:0001404)1.66228121
125Respiratory insufficiency due to muscle weakness (HP:0002747)1.65515497
126Increased intramyocellular lipid droplets (HP:0012240)1.63193326
127Abnormality of the foot musculature (HP:0001436)1.63161263
128Lower limb amyotrophy (HP:0007210)1.59832410
129Hyperthyroidism (HP:0000836)1.58662905
130Poor eye contact (HP:0000817)1.58440968
131Type 2 muscle fiber atrophy (HP:0003554)1.58065044
132Absence seizures (HP:0002121)1.57262996
133Abnormality of the shoulder girdle musculature (HP:0001435)1.57050910
134Increased muscle lipid content (HP:0009058)1.49955243
135Foot dorsiflexor weakness (HP:0009027)1.49212880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.40930400
2OBSCN3.88091523
3PHKG13.82974570
4PHKG23.82974570
5INSRR3.76236474
6TRIB32.54205466
7LMTK22.52322526
8PRKD32.38508253
9DMPK2.35281047
10PDK32.32706605
11PDK42.32706605
12NTRK32.19905742
13PINK12.12506081
14MYLK1.99627670
15PKN21.95961970
16MUSK1.74148748
17NEK11.60791235
18MAP2K61.51054572
19PIK3CA1.49392779
20MAP3K41.48085315
21PAK31.47832673
22EPHA41.46426980
23CDC42BPA1.46068728
24BCKDK1.44156268
25WNK41.35908492
26TRPM71.29508205
27NME11.27636500
28MAP3K11.25391682
29LIMK11.25240658
30HIPK21.16178567
31CASK1.14174879
32PDK21.14138011
33PRKD11.12890002
34PDGFRA1.10424401
35PRKCH1.09055120
36MAP2K41.08355482
37TAOK31.08189830
38TIE11.05823748
39PASK1.05611892
40MAPK131.03668357
41PRKAA11.03571606
42RIPK11.02175373
43UHMK11.01238572
44MAP3K71.00829332
45MAP3K20.96894807
46* CAMK2D0.96165290
47STK240.95386643
48STK380.94575496
49MAPK150.93827296
50FLT30.93718895
51KSR20.92202334
52PAK60.89739380
53WNK10.89488963
54CAMKK20.88922047
55NTRK10.88262696
56MAP4K20.88244500
57DAPK20.87443499
58CAMKK10.84934382
59CAMK2A0.84574566
60EEF2K0.81155032
61BMPR1B0.80246528
62RET0.77713946
63MAP3K90.77319661
64PIK3CG0.75292746
65GRK70.73965440
66PRKCE0.73850169
67TNK20.73356055
68FER0.71881757
69MAP2K70.70722879
70FGFR20.69306161
71CCNB10.68957545
72AKT20.68247162
73MAPK120.65955002
74CAMK10.65374771
75SGK30.64089182
76ROCK10.63962528
77MAP3K50.63027860
78PDPK10.62973775
79CAMK40.62599199
80CSNK1G10.61215720
81ERBB30.60106308
82CSNK1G20.59058659
83PRKAA20.58625839
84GRK10.56894687
85CDK50.56683497
86WNK30.55911645
87SGK20.54834071
88SGK10.54393338
89PDK10.54159407
90ILK0.54078774
91PTK60.53316075
92CAMK2G0.52278893
93TAOK10.50909369
94CSNK1G30.50166844
95PRKACG0.49714264
96* PRKACA0.49543331
97PRKD20.49075298
98CAMK2B0.49039404
99MARK10.47965942
100SGK2230.47487358
101SGK4940.47487358
102DAPK30.47215234
103NTRK20.46457851
104RPS6KA20.45557656
105ADRBK20.45422995
106MAP2K30.45255009
107PKN10.43613682
108RPS6KA30.43370070
109RPS6KB10.41983688
110MAP2K10.41875555
111GRK50.41317976
112MARK20.41214643
113PTK2B0.41139883
114MINK10.40079701
115STK110.39139058
116TAF10.38889787
117OXSR10.38695628
118PRKACB0.37717219
119FRK0.35697866
120MAPK110.33174304
121EPHA30.32860467
122MOS0.32078966
123PRKG10.32054660
124MAPKAPK30.31713728
125PRKCG0.31597692
126CSNK1A1L0.31002574
127CSNK1A10.30235296
128CSNK1D0.27154326
129DAPK10.26772287
130PLK20.26439285
131ZAK0.25962169
132DYRK1A0.25680722
133PRKCI0.24240063
134NLK0.23793951
135MAPK100.22973848
136MAPK70.21415220

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.35839087
2Cardiac muscle contraction_Homo sapiens_hsa042603.22915983
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.06476790
4Dilated cardiomyopathy_Homo sapiens_hsa054142.93125687
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.69610600
6* Insulin secretion_Homo sapiens_hsa049112.40397699
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33335120
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.08978164
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01498638
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96286444
11Oxidative phosphorylation_Homo sapiens_hsa001901.89046532
12Parkinsons disease_Homo sapiens_hsa050121.86632646
13* Type II diabetes mellitus_Homo sapiens_hsa049301.79605975
14Alzheimers disease_Homo sapiens_hsa050101.71180438
15Arginine and proline metabolism_Homo sapiens_hsa003301.68535356
16Circadian entrainment_Homo sapiens_hsa047131.65714137
17Propanoate metabolism_Homo sapiens_hsa006401.59095632
18Glucagon signaling pathway_Homo sapiens_hsa049221.49951340
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48106717
20Nitrogen metabolism_Homo sapiens_hsa009101.42409626
21Long-term potentiation_Homo sapiens_hsa047201.42080662
22Amphetamine addiction_Homo sapiens_hsa050311.41698725
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39643833
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39184395
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.38508510
26Arginine biosynthesis_Homo sapiens_hsa002201.34268598
27GABAergic synapse_Homo sapiens_hsa047271.33075219
28Calcium signaling pathway_Homo sapiens_hsa040201.32152080
29Phototransduction_Homo sapiens_hsa047441.30606966
30Fatty acid degradation_Homo sapiens_hsa000711.28943686
31Oxytocin signaling pathway_Homo sapiens_hsa049211.27493482
32Taste transduction_Homo sapiens_hsa047421.27418147
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25410909
34Insulin resistance_Homo sapiens_hsa049311.25398251
35Gastric acid secretion_Homo sapiens_hsa049711.24180823
36Renin secretion_Homo sapiens_hsa049241.23690656
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21908931
38Cholinergic synapse_Homo sapiens_hsa047251.21322907
39Morphine addiction_Homo sapiens_hsa050321.20199135
40Carbon metabolism_Homo sapiens_hsa012001.18959343
41Synaptic vesicle cycle_Homo sapiens_hsa047211.17752970
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16272970
43Dopaminergic synapse_Homo sapiens_hsa047281.15343527
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12417499
45Circadian rhythm_Homo sapiens_hsa047101.10970805
46Fatty acid elongation_Homo sapiens_hsa000621.10785914
47Insulin signaling pathway_Homo sapiens_hsa049101.10765841
48Olfactory transduction_Homo sapiens_hsa047401.10276822
49Pancreatic secretion_Homo sapiens_hsa049721.08864509
50Cocaine addiction_Homo sapiens_hsa050301.07206996
51beta-Alanine metabolism_Homo sapiens_hsa004101.07130552
52Glutamatergic synapse_Homo sapiens_hsa047241.06805985
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.06682447
54Huntingtons disease_Homo sapiens_hsa050161.05869357
55Regulation of autophagy_Homo sapiens_hsa041401.04549105
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99818182
57cAMP signaling pathway_Homo sapiens_hsa040240.96173691
58Vitamin B6 metabolism_Homo sapiens_hsa007500.95862829
59Fatty acid metabolism_Homo sapiens_hsa012120.94896435
60Butanoate metabolism_Homo sapiens_hsa006500.94678881
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93178770
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93096392
63Salivary secretion_Homo sapiens_hsa049700.92597041
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91114343
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89490707
66Pentose phosphate pathway_Homo sapiens_hsa000300.86673043
67Pyruvate metabolism_Homo sapiens_hsa006200.85978068
68GnRH signaling pathway_Homo sapiens_hsa049120.84827428
69Type I diabetes mellitus_Homo sapiens_hsa049400.83959217
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.82615323
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82483024
72Nicotine addiction_Homo sapiens_hsa050330.81553190
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80792591
74Vibrio cholerae infection_Homo sapiens_hsa051100.80476578
75Starch and sucrose metabolism_Homo sapiens_hsa005000.80222368
76Estrogen signaling pathway_Homo sapiens_hsa049150.79580676
77Peroxisome_Homo sapiens_hsa041460.78985336
78Sulfur metabolism_Homo sapiens_hsa009200.76683034
79Serotonergic synapse_Homo sapiens_hsa047260.75946923
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74142744
81Protein export_Homo sapiens_hsa030600.72665929
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71778425
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71570264
84AMPK signaling pathway_Homo sapiens_hsa041520.70736640
85Gap junction_Homo sapiens_hsa045400.69649476
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68394297
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65001948
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64678074
89Dorso-ventral axis formation_Homo sapiens_hsa043200.64035584
90Galactose metabolism_Homo sapiens_hsa000520.60402669
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59611831
92Viral myocarditis_Homo sapiens_hsa054160.58561936
93Long-term depression_Homo sapiens_hsa047300.58431907
94mTOR signaling pathway_Homo sapiens_hsa041500.55707244
95Thyroid hormone synthesis_Homo sapiens_hsa049180.55162850
96ABC transporters_Homo sapiens_hsa020100.55086054
97Collecting duct acid secretion_Homo sapiens_hsa049660.54778703
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54002505
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51761233
100Oocyte meiosis_Homo sapiens_hsa041140.48752467
101Biosynthesis of amino acids_Homo sapiens_hsa012300.48588442
102Melanogenesis_Homo sapiens_hsa049160.46329876
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42999075
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41624438
105Fructose and mannose metabolism_Homo sapiens_hsa000510.40623256
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.39083577
107Tight junction_Homo sapiens_hsa045300.39017282
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38289268
109Focal adhesion_Homo sapiens_hsa045100.37988532
110Metabolic pathways_Homo sapiens_hsa011000.37436519
111MAPK signaling pathway_Homo sapiens_hsa040100.37064146
112Bile secretion_Homo sapiens_hsa049760.34565536
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34465657
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33873855
115Phenylalanine metabolism_Homo sapiens_hsa003600.33374104
116Inositol phosphate metabolism_Homo sapiens_hsa005620.33314703
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33029006
118Purine metabolism_Homo sapiens_hsa002300.32348454
119Renal cell carcinoma_Homo sapiens_hsa052110.31265710
120Ovarian steroidogenesis_Homo sapiens_hsa049130.31126317
121Tryptophan metabolism_Homo sapiens_hsa003800.30646547
122Glioma_Homo sapiens_hsa052140.29925838
123Lysine degradation_Homo sapiens_hsa003100.29840071
124HIF-1 signaling pathway_Homo sapiens_hsa040660.28498719
125Prolactin signaling pathway_Homo sapiens_hsa049170.28389624

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »