KCNJ13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization (GO:0086009)9.95194265
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.89748540
3regulation of guanylate cyclase activity (GO:0031282)7.76398890
4ventricular cardiac muscle cell action potential (GO:0086005)7.36516318
5lipoprotein transport (GO:0042953)7.30560004
6regulation of heart rate by cardiac conduction (GO:0086091)7.26726583
7folic acid transport (GO:0015884)7.00732300
8regulation of membrane repolarization (GO:0060306)6.70788251
9epoxygenase P450 pathway (GO:0019373)6.70298675
10regulation of bile acid biosynthetic process (GO:0070857)6.68515592
11regulation of potassium ion transmembrane transporter activity (GO:1901016)6.36905141
12NADH metabolic process (GO:0006734)6.32224937
13positive regulation of guanylate cyclase activity (GO:0031284)6.29167086
14fat-soluble vitamin biosynthetic process (GO:0042362)6.21753502
15intestinal absorption (GO:0050892)6.14914534
16cardiac conduction (GO:0061337)6.01983929
17negative regulation of complement activation (GO:0045916)5.74213868
18phenylpropanoid metabolic process (GO:0009698)5.67172857
19omega-hydroxylase P450 pathway (GO:0097267)5.65093934
20regulation of systemic arterial blood pressure by hormone (GO:0001990)5.52399196
21regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.52399196
22endocrine process (GO:0050886)5.52399196
23regulation of cellular extravasation (GO:0002691)5.46332706
24hormone catabolic process (GO:0042447)5.40110152
25fructose metabolic process (GO:0006000)5.21515410
26regulation of cGMP biosynthetic process (GO:0030826)5.03078256
27prostate gland growth (GO:0060736)4.99939191
28drug metabolic process (GO:0017144)4.98892214
29retinol metabolic process (GO:0042572)4.98116147
30mitochondrion distribution (GO:0048311)4.97989243
31regulation of systemic arterial blood pressure (GO:0003073)4.95704969
32valine metabolic process (GO:0006573)4.94329000
33peptide hormone processing (GO:0016486)4.91550326
34cardiac muscle cell action potential involved in contraction (GO:0086002)4.89284822
35regulation of potassium ion transmembrane transport (GO:1901379)4.88581104
36adhesion of symbiont to host cell (GO:0044650)4.86634761
37virion attachment to host cell (GO:0019062)4.86634761
38negative regulation of protein activation cascade (GO:2000258)4.82967915
39positive regulation of glycoprotein biosynthetic process (GO:0010560)4.75798545
40cardiac muscle cell action potential (GO:0086001)4.69623587
41digestion (GO:0007586)4.65694505
42cellular glucuronidation (GO:0052695)4.61790237
43glycerophospholipid catabolic process (GO:0046475)4.61457980
44uronic acid metabolic process (GO:0006063)4.58589237
45glucuronate metabolic process (GO:0019585)4.58589237
46regulation of triglyceride catabolic process (GO:0010896)4.52944894
47bile acid and bile salt transport (GO:0015721)4.50248423
48polyol transport (GO:0015791)4.49650919
49very-low-density lipoprotein particle assembly (GO:0034379)4.43664458
50melanin metabolic process (GO:0006582)4.42970506
51detection of temperature stimulus (GO:0016048)4.42173035
52receptor guanylyl cyclase signaling pathway (GO:0007168)4.37951278
53diacylglycerol metabolic process (GO:0046339)4.36062009
54melanin biosynthetic process (GO:0042438)4.35411243
55cellular copper ion homeostasis (GO:0006878)4.32696745
56regulation of cGMP metabolic process (GO:0030823)4.24100788
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.23528196
58multicellular organismal signaling (GO:0035637)4.15279809
59peptide catabolic process (GO:0043171)4.15058075
60urea cycle (GO:0000050)4.13270520
61tyrosine metabolic process (GO:0006570)4.12661301
62positive regulation of glycoprotein metabolic process (GO:1903020)4.08887383
63antibacterial humoral response (GO:0019731)4.07228287
64negative regulation of humoral immune response (GO:0002921)4.05944466
65xenobiotic catabolic process (GO:0042178)4.05545846
66drug catabolic process (GO:0042737)4.05074343
67alkaloid metabolic process (GO:0009820)4.00764721
68fat-soluble vitamin metabolic process (GO:0006775)3.98317586
69positive regulation of cGMP biosynthetic process (GO:0030828)3.97918785
70secondary metabolite biosynthetic process (GO:0044550)3.97056942
71homocysteine metabolic process (GO:0050667)3.96606368
72urea metabolic process (GO:0019627)3.95480520
73adhesion of symbiont to host (GO:0044406)3.94211692
74regulation of phospholipid biosynthetic process (GO:0071071)3.91274117
75glycolipid catabolic process (GO:0019377)3.90624915
76glycosphingolipid catabolic process (GO:0046479)3.87819528
77vitamin transmembrane transport (GO:0035461)3.86034509
78antimicrobial humoral response (GO:0019730)3.85277525
79drinking behavior (GO:0042756)3.84947250
80plasma lipoprotein particle assembly (GO:0034377)3.81133113
81cGMP biosynthetic process (GO:0006182)3.80192753
82exogenous drug catabolic process (GO:0042738)3.76166028
83cellular response to nitric oxide (GO:0071732)3.75219962
84arginine metabolic process (GO:0006525)3.73338114
85ventricular system development (GO:0021591)3.72049371
86renal system process involved in regulation of blood volume (GO:0001977)3.71037352
87transepithelial transport (GO:0070633)3.66387964
88lipoprotein metabolic process (GO:0042157)3.65669516
89cell volume homeostasis (GO:0006884)3.65481271
90nitrogen cycle metabolic process (GO:0071941)3.58377416
91ear development (GO:0043583)3.48217165
92mRNA modification (GO:0016556)3.48013111
93midgut development (GO:0007494)3.46569510
94activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.46511978
95regulation of vitamin metabolic process (GO:0030656)3.46164753
96neurotransmitter catabolic process (GO:0042135)3.45124632
97positive regulation of cGMP metabolic process (GO:0030825)3.43548293
98glomerulus development (GO:0032835)3.43145070
99hypotonic response (GO:0006971)3.41905385
100positive regulation of pseudopodium assembly (GO:0031274)3.41157942
101bile acid metabolic process (GO:0008206)3.40798984
102glycosylceramide metabolic process (GO:0006677)3.40696927
103vitamin D metabolic process (GO:0042359)3.37079226
104phenol-containing compound catabolic process (GO:0019336)3.35532918
105auditory receptor cell differentiation (GO:0042491)3.34583119
106positive regulation of cellular amide metabolic process (GO:0034250)3.34334765
107response to nitric oxide (GO:0071731)3.32101690
108ceramide catabolic process (GO:0046514)3.31526090
109cGMP-mediated signaling (GO:0019934)3.30004699
110vitamin biosynthetic process (GO:0009110)3.29263068
111maintenance of gastrointestinal epithelium (GO:0030277)3.28977819
112protein-lipid complex assembly (GO:0065005)3.28792954
113sulfur compound transport (GO:0072348)3.28284314
114regulation of protein glycosylation (GO:0060049)3.27429159
115renal filtration (GO:0097205)3.26710484
116drug transport (GO:0015893)3.25919367
117drug transmembrane transport (GO:0006855)3.24398110
118cobalamin metabolic process (GO:0009235)3.21912399
119primary alcohol metabolic process (GO:0034308)3.20742707
120auditory behavior (GO:0031223)3.18672500
121glycerol metabolic process (GO:0006071)3.17906881
122phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.17549677
123negative regulation of epidermal cell differentiation (GO:0045605)3.12237694
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10467115
125modified amino acid transport (GO:0072337)3.09979961
126phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.09709669
127proline transport (GO:0015824)3.09408063
128fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.07983849
129vitamin transport (GO:0051180)3.06234299
130negative regulation of steroid metabolic process (GO:0045939)3.05922052
131glutamine family amino acid biosynthetic process (GO:0009084)3.04246038
132bicarbonate transport (GO:0015701)3.04126608
133regulation of pseudopodium assembly (GO:0031272)3.03716944
134cellular response to reactive nitrogen species (GO:1902170)3.02321065
135digestive system process (GO:0022600)3.01804169
136urate metabolic process (GO:0046415)3.01142061
137glucose 6-phosphate metabolic process (GO:0051156)2.99954567
138regulation of beta-amyloid formation (GO:1902003)2.99270727
139head development (GO:0060322)2.98939753
140phospholipid efflux (GO:0033700)2.98170517
141vitamin A metabolic process (GO:0006776)2.97812323
142regulation of pigment cell differentiation (GO:0050932)2.97305679
143cytidine deamination (GO:0009972)2.95715467
144cytidine catabolic process (GO:0006216)2.95715467
145otic vesicle formation (GO:0030916)2.94232663
146mammary gland alveolus development (GO:0060749)2.93758866
147removal of superoxide radicals (GO:0019430)2.89838332
148cellular response to superoxide (GO:0071451)2.89838332
149cellular response to oxygen radical (GO:0071450)2.89838332
150dentate gyrus development (GO:0021542)2.82373916
151copper ion homeostasis (GO:0055070)2.80797698
152regulation of potassium ion transport (GO:0043266)2.80212493
153macroautophagy (GO:0016236)2.75671261
154regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.74071735
155positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.74071735
156secondary metabolic process (GO:0019748)2.67446904
157response to auditory stimulus (GO:0010996)2.65990847
158positive regulation of respiratory burst (GO:0060267)2.61159490
159negative regulation of cAMP-mediated signaling (GO:0043951)2.60986394
160negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59925904
161response to nitrosative stress (GO:0051409)2.59818772
162flavonoid metabolic process (GO:0009812)2.54975149
163cerebellar Purkinje cell differentiation (GO:0021702)2.54794728
164regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52949973
165positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52949973
166innervation (GO:0060384)2.50240493
167cellular response to drug (GO:0035690)2.49133845
168lung vasculature development (GO:0060426)2.47246076
169S-adenosylmethionine metabolic process (GO:0046500)2.46586172
170hyperosmotic salinity response (GO:0042538)2.42055195
171regulation of cation channel activity (GO:2001257)2.42014219
172folic acid metabolic process (GO:0046655)2.38838902
173branched-chain amino acid catabolic process (GO:0009083)2.38662022
174glomerular filtration (GO:0003094)2.37394489
175lung epithelium development (GO:0060428)2.35019002
176chloride transmembrane transport (GO:1902476)2.34767027
177regulation of amyloid precursor protein catabolic process (GO:1902991)2.34688018
178relaxation of cardiac muscle (GO:0055119)2.34178211
179glial cell proliferation (GO:0014009)2.33481760
180positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052)2.33358367
181positive regulation of proteasomal protein catabolic process (GO:1901800)2.33223257
182sodium-independent organic anion transport (GO:0043252)2.32859252
183regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.32036823
184positive regulation of bone mineralization (GO:0030501)2.31882521
185serotonin metabolic process (GO:0042428)2.29883657
186positive regulation of cellular protein catabolic process (GO:1903364)2.28325183
187chloride transport (GO:0006821)2.25530821
188negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.25243494
189response to superoxide (GO:0000303)2.24250336
190positive regulation of cholesterol efflux (GO:0010875)2.23867381
191membrane repolarization during action potential (GO:0086011)13.6248997
192tongue development (GO:0043586)13.2838682
193potassium ion export (GO:0071435)12.4460853
194angiotensin maturation (GO:0002003)12.0165098
195regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)10.8473196
196potassium ion import (GO:0010107)10.8060686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human4.01187339
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.68542962
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.29367414
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.21468555
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04499465
6* GATA4_25053715_ChIP-Seq_YYC3_Human2.52032678
7AR_21572438_ChIP-Seq_LNCaP_Human2.49603904
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.40662832
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.33368946
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.29652901
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.26905198
12SALL4_18804426_ChIP-ChIP_XEN_Mouse2.26168465
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16879461
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.11275984
15TP53_18474530_ChIP-ChIP_U2OS_Human2.08910958
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07416959
17CDX2_22108803_ChIP-Seq_LS180_Human2.01365474
18IGF1R_20145208_ChIP-Seq_DFB_Human1.99925376
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96836900
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93455497
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92478178
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92125394
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92125394
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92125394
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86563181
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.84882158
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84858968
28GATA1_22025678_ChIP-Seq_K562_Human1.83183684
29VDR_22108803_ChIP-Seq_LS180_Human1.82716675
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80120675
31DROSHA_22980978_ChIP-Seq_HELA_Human1.79619769
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.77451468
33GATA6_25053715_ChIP-Seq_YYC3_Human1.74458592
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74016772
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74016772
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.73361703
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73154173
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71662554
39BCAT_22108803_ChIP-Seq_LS180_Human1.67688037
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.65685317
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.64599832
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64432944
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62770745
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62414448
45TP53_16413492_ChIP-PET_HCT116_Human1.62389179
46FUS_26573619_Chip-Seq_HEK293_Human1.61048782
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58723972
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.58085169
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57313707
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56645637
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55767219
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50231421
53GBX2_23144817_ChIP-Seq_PC3_Human1.48338005
54RUNX_20019798_ChIP-Seq_JUKART_Human1.45868419
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.45806472
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42881517
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42201891
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41925539
59* TCF4_22108803_ChIP-Seq_LS180_Human1.40594249
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39708981
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37323183
62SOX2_20726797_ChIP-Seq_SW620_Human1.35696466
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35359530
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34708291
65P300_19829295_ChIP-Seq_ESCs_Human1.32505942
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.32095371
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32066820
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.31342836
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30948766
70CLOCK_20551151_ChIP-Seq_293T_Human1.30594332
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.30451061
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28481543
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28257133
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27580862
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.27093987
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27048515
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26379348
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.25250949
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.25213562
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24791959
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23837094
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.23754954
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23495363
84* SMAD4_21799915_ChIP-Seq_A2780_Human1.23304872
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23161861
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.22880784
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22767656
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21268883
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21156134
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20962749
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20934270
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.20027079
93STAT1_20625510_ChIP-Seq_HELA_Human1.19690269
94AHR_22903824_ChIP-Seq_MCF-7_Human1.19634274
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17332048
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16714953
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16652178
98AR_25329375_ChIP-Seq_VCAP_Human1.16449266
99HNF4A_19822575_ChIP-Seq_HepG2_Human1.16383037
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15620452
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15414864
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14926328
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14895317
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14808016
105ER_23166858_ChIP-Seq_MCF-7_Human1.14692352
106IRF8_22096565_ChIP-ChIP_GC-B_Human1.14376443
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.13250542
108STAT3_23295773_ChIP-Seq_U87_Human1.13077705
109CBP_20019798_ChIP-Seq_JUKART_Human1.12647034
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12647034
111TP63_23658742_ChIP-Seq_EP156T_Human1.11979584
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11359923
113* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10988263
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10785044
115HNFA_21074721_ChIP-Seq_CACO-2_Human1.10429968
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10326724
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.10326724
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09959827
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09670842
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09620580
121RXR_22108803_ChIP-Seq_LS180_Human1.08385113
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08347338
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08325120
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.08135736
125CJUN_26792858_Chip-Seq_BT549_Human1.07548177
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06694893
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.06172880
128SMAD3_21741376_ChIP-Seq_HESCs_Human1.05929988
129VDR_24787735_ChIP-Seq_THP-1_Human1.05554783
130* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05346602
131* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05327922
132TRIM28_21343339_ChIP-Seq_HEK293_Human1.05238351
133LXR_22158963_ChIP-Seq_LIVER_Mouse1.04700700
134TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04470333
135TAL1_26923725_Chip-Seq_HPCs_Mouse1.04132667
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03506539
137NFYA_21822215_ChIP-Seq_K562_Human1.02873303
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02246192
139ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02175571
140ETV1_20927104_ChIP-Seq_GIST48_Human1.02159925
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01951172
142EZH2_27294783_Chip-Seq_ESCs_Mouse1.01838517
143NFYB_21822215_ChIP-Seq_K562_Human1.01358904
144TBL1_22424771_ChIP-Seq_293T_Human1.01280110
145ESR1_21235772_ChIP-Seq_MCF-7_Human1.01272072
146NCOR_22424771_ChIP-Seq_293T_Human0.99500658
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99402053
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98720627
149TCF4_23295773_ChIP-Seq_U87_Human0.98585183
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.97810818
151PHF8_20622853_ChIP-Seq_HELA_Human0.97716557
152AR_20517297_ChIP-Seq_VCAP_Human0.97617041
153RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96541311
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96512586
155NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95776499
156KDM2B_26808549_Chip-Seq_REH_Human0.95502030
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.95432199
158FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94718810
159PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94094193
160RXR_22158963_ChIP-Seq_LIVER_Mouse0.93858387
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.93566073
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93044057
163NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93044057
164RNF2_27304074_Chip-Seq_ESCs_Mouse0.92968458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.35289940
2MP0000372_irregular_coat_pigmentation5.64020038
3MP0001666_abnormal_nutrient_absorption5.00328167
4MP0003011_delayed_dark_adaptation4.82076436
5MP0003183_abnormal_peptide_metabolism4.53113467
6MP0004147_increased_porphyrin_level4.15781765
7MP0001346_abnormal_lacrimal_gland4.14164113
8MP0005365_abnormal_bile_salt3.76276189
9MP0004019_abnormal_vitamin_homeostasis3.63124950
10MP0004264_abnormal_extraembryonic_tissu3.51964950
11MP0009379_abnormal_foot_pigmentation3.40861326
12MP0005171_absent_coat_pigmentation3.17114615
13MP0000566_synostosis3.10623790
14MP0005248_abnormal_Harderian_gland2.97894907
15MP0001958_emphysema2.70379330
16MP0005408_hypopigmentation2.59297456
17MP0010155_abnormal_intestine_physiology2.32573464
18MP0010234_abnormal_vibrissa_follicle2.12267656
19MP0003868_abnormal_feces_composition2.09226589
20MP0008004_abnormal_stomach_pH13.4681082
21MP0001764_abnormal_homeostasis1.95867279
22MP0005409_darkened_coat_color1.88551653
23MP0003806_abnormal_nucleotide_metabolis1.86194655
24MP0000538_abnormal_urinary_bladder1.77472424
25MP0009643_abnormal_urine_homeostasis1.74718136
26MP0003252_abnormal_bile_duct1.70796178
27MP0005379_endocrine/exocrine_gland_phen1.64581763
28MP0004272_abnormal_basement_membrane1.63966971
29MP0002876_abnormal_thyroid_physiology1.61536477
30MP0008789_abnormal_olfactory_epithelium1.57961348
31MP0010030_abnormal_orbit_morphology1.57670163
32MP0005174_abnormal_tail_pigmentation1.57501398
33MP0005666_abnormal_adipose_tissue1.54921731
34MP0003866_abnormal_defecation1.51865853
35MP0001177_atelectasis1.50824185
36MP0002822_catalepsy1.49165056
37MP0003718_maternal_effect1.48442088
38MP0003186_abnormal_redox_activity1.46066861
39MP0002108_abnormal_muscle_morphology1.39024180
40MP0000490_abnormal_crypts_of1.38929149
41MP0005394_taste/olfaction_phenotype1.37707738
42MP0005499_abnormal_olfactory_system1.37707738
43MP0001188_hyperpigmentation1.36774224
44MP0001765_abnormal_ion_homeostasis1.36433689
45MP0004782_abnormal_surfactant_physiolog1.34678325
46MP0001501_abnormal_sleep_pattern1.33969298
47MP0005636_abnormal_mineral_homeostasis1.33170088
48MP0000462_abnormal_digestive_system1.30957660
49MP0001324_abnormal_eye_pigmentation1.27819174
50MP0004270_analgesia1.25676918
51MP0000477_abnormal_intestine_morphology1.23389818
52MP0002971_abnormal_brown_adipose1.22844999
53MP0009840_abnormal_foam_cell1.18271799
54MP0005448_abnormal_energy_balance1.17668329
55MP0002136_abnormal_kidney_physiology1.16541414
56MP0005075_abnormal_melanosome_morpholog1.14566395
57MP0005166_decreased_susceptibility_to1.14016636
58MP0002118_abnormal_lipid_homeostasis1.13725673
59MP0001664_abnormal_digestion1.12777028
60MP0000569_abnormal_digit_pigmentation1.12393639
61MP0000678_abnormal_parathyroid_gland1.12044033
62MP0001873_stomach_inflammation1.10911170
63MP0005670_abnormal_white_adipose1.10693954
64MP0010352_gastrointestinal_tract_polyps1.09748707
65MP0003632_abnormal_nervous_system1.09618408
66MP0003279_aneurysm1.08179182
67MP0000470_abnormal_stomach_morphology1.08143271
68MP0005367_renal/urinary_system_phenotyp1.07326769
69MP0000516_abnormal_urinary_system1.07326769
70MP0000015_abnormal_ear_pigmentation1.05305005
71MP0001756_abnormal_urination1.04065301
72MP0003786_premature_aging1.00966544
73MP0000371_diluted_coat_color0.99438877
74MP0003136_yellow_coat_color0.96718820
75MP0000537_abnormal_urethra_morphology0.94621660
76MP0004043_abnormal_pH_regulation0.94444282
77MP0001663_abnormal_digestive_system0.93043832
78MP0002877_abnormal_melanocyte_morpholog0.92943428
79MP0000631_abnormal_neuroendocrine_gland0.92737385
80MP0003191_abnormal_cellular_cholesterol0.92273627
81MP0000230_abnormal_systemic_arterial0.90849551
82MP0010678_abnormal_skin_adnexa0.88597922
83MP0005646_abnormal_pituitary_gland0.88108854
84MP0002928_abnormal_bile_duct0.87558343
85MP0003941_abnormal_skin_development0.87548950
86MP0003879_abnormal_hair_cell0.86076512
87MP0009697_abnormal_copulation0.85502727
88MP0003690_abnormal_glial_cell0.85490473
89MP0001919_abnormal_reproductive_system0.84295819
90MP0005375_adipose_tissue_phenotype0.82926547
91MP0009780_abnormal_chondrocyte_physiolo0.82341380
92MP0002168_other_aberrant_phenotype0.81491871
93MP0005381_digestive/alimentary_phenotyp0.81379466
94MP0002295_abnormal_pulmonary_circulatio0.79028295
95MP0005388_respiratory_system_phenotype0.78803964
96MP0002133_abnormal_respiratory_system0.78803964
97MP0002254_reproductive_system_inflammat0.77994088
98MP0000609_abnormal_liver_physiology0.77385770
99MP0009115_abnormal_fat_cell0.76860417
100MP0004381_abnormal_hair_follicle0.74303113
101MP0002090_abnormal_vision0.73415610
102MP0004859_abnormal_synaptic_plasticity0.72490174
103MP0009384_cardiac_valve_regurgitation0.71634079
104MP0005197_abnormal_uvea_morphology0.71144462
105MP0003631_nervous_system_phenotype0.70722384
106MP0000383_abnormal_hair_follicle0.70606071
107MP0005319_abnormal_enzyme/_coenzyme0.70353061
108MP0005535_abnormal_body_temperature0.69615327
109MP0003938_abnormal_ear_development0.69538788
110MP0008875_abnormal_xenobiotic_pharmacok0.69523301
111MP0005584_abnormal_enzyme/coenzyme_acti0.69262531
112MP0005085_abnormal_gallbladder_physiolo0.68957271
113MP0008961_abnormal_basal_metabolism0.66919880
114MP0005551_abnormal_eye_electrophysiolog0.65798696
115MP0008438_abnormal_cutaneous_collagen0.64696756
116MP0001186_pigmentation_phenotype0.64421364
117MP0005253_abnormal_eye_physiology0.63976720
118MP0002098_abnormal_vibrissa_morphology0.63450288
119MP0008775_abnormal_heart_ventricle0.63405685
120MP0001440_abnormal_grooming_behavior0.60750363
121MP0008872_abnormal_physiological_respon0.58607135
122MP0005332_abnormal_amino_acid0.58449048
123MP0000778_abnormal_nervous_system0.57697215
124MP0002938_white_spotting0.57520712
125MP0002095_abnormal_skin_pigmentation0.56506549
126MP0004142_abnormal_muscle_tone0.56431025
127MP0009642_abnormal_blood_homeostasis0.56135295
128MP0005376_homeostasis/metabolism_phenot0.55058761
129MP0003300_gastrointestinal_ulcer0.50293405
130MP0003638_abnormal_response/metabolism_0.50070129
131MP0001845_abnormal_inflammatory_respons0.50029744
132MP0003137_abnormal_impulse_conducting0.49845309
133MP0002078_abnormal_glucose_homeostasis0.49722013
134MP0001485_abnormal_pinna_reflex0.49433713
135MP0005257_abnormal_intraocular_pressure0.48948100
136MP0004883_abnormal_blood_vessel0.48888990
137MP0000427_abnormal_hair_cycle0.48769376
138MP0004484_altered_response_of0.48733425
139MP0009764_decreased_sensitivity_to0.48012187
140MP0005503_abnormal_tendon_morphology0.47869661
141MP0002075_abnormal_coat/hair_pigmentati0.46648963
142MP0005410_abnormal_fertilization0.46319035
143MP0003315_abnormal_perineum_morphology0.46210166
144MP0000613_abnormal_salivary_gland0.45044964
145MP0002557_abnormal_social/conspecific_i0.45021452
146MP0000534_abnormal_ureter_morphology0.44488595
147MP0002396_abnormal_hematopoietic_system0.44396161
148MP0002751_abnormal_autonomic_nervous0.44179980
149MP0000762_abnormal_tongue_morphology0.44073815
150MP0010329_abnormal_lipoprotein_level0.43995279
151MP0004215_abnormal_myocardial_fiber0.43706322
152MP0002166_altered_tumor_susceptibility0.43479788
153MP0006138_congestive_heart_failure0.43018864
154MP0008469_abnormal_protein_level0.42988863
155MP0002896_abnormal_bone_mineralization0.42501460
156MP0002139_abnormal_hepatobiliary_system0.41792654
157MP0000647_abnormal_sebaceous_gland0.41786465
158MP0003633_abnormal_nervous_system0.41526313
159MP0000465_gastrointestinal_hemorrhage0.40875136
160MP0001944_abnormal_pancreas_morphology0.40469609
161MP0004233_abnormal_muscle_weight0.40227079
162MP0003953_abnormal_hormone_level0.39870929
163MP0005083_abnormal_biliary_tract0.37354866
164MP0002233_abnormal_nose_morphology0.35527416
165MP0000367_abnormal_coat/_hair0.34398606
166MP0008995_early_reproductive_senescence0.33604668
167MP0000681_abnormal_thyroid_gland0.32970029
168MP0001502_abnormal_circadian_rhythm0.32420881
169MP0003329_amyloid_beta_deposits0.31911763

Predicted human phenotypes

RankGene SetZ-score
1Prolonged QT interval (HP:0001657)7.14313650
2Hydroxyprolinuria (HP:0003080)6.91953289
3Abnormality of proline metabolism (HP:0010907)6.91953289
4Malnutrition (HP:0004395)6.86245662
5Abnormality of the fovea (HP:0000493)6.19717775
6Vascular calcification (HP:0004934)6.16592577
7Hypobetalipoproteinemia (HP:0003563)5.97830609
8Syncope (HP:0001279)5.64612733
9Abnormality of the vitamin B12 metabolism (HP:0004341)5.62151080
10Chronic diarrhea (HP:0002028)5.58720333
11Cardiovascular calcification (HP:0011915)5.57235494
12Increased CSF protein (HP:0002922)5.40936802
13Acanthocytosis (HP:0001927)5.01638160
14Fat malabsorption (HP:0002630)4.84422789
15Confusion (HP:0001289)4.82512136
16Widely patent fontanelles and sutures (HP:0004492)4.75434994
17Orthostatic hypotension (HP:0001278)4.63050667
18Pigmentary retinal degeneration (HP:0001146)4.38545368
19Ileus (HP:0002595)4.37921276
20Hyperglycinuria (HP:0003108)4.23222581
21Glycosuria (HP:0003076)4.19885260
22Abnormality of urine glucose concentration (HP:0011016)4.19885260
23Abnormality of renal resorption (HP:0011038)3.99274722
24Hyperphosphatemia (HP:0002905)3.87867348
25Atrial fibrillation (HP:0005110)3.86364602
26Proximal tubulopathy (HP:0000114)3.86128101
27Choroideremia (HP:0001139)3.80744694
28Congenital sensorineural hearing impairment (HP:0008527)3.70484142
29Abnormal EKG (HP:0003115)3.66862274
30Metabolic alkalosis (HP:0200114)3.59691396
31Primary atrial arrhythmia (HP:0001692)3.59551640
32Abnormality of serine family amino acid metabolism (HP:0010894)3.55401143
33Abnormality of glycine metabolism (HP:0010895)3.55401143
34Hypoplasia of the fovea (HP:0007750)3.47400374
35Aplasia/Hypoplasia of the fovea (HP:0008060)3.47400374
36Ventricular arrhythmia (HP:0004308)3.43217001
37Supraventricular tachycardia (HP:0004755)3.41458288
38Facial shape deformation (HP:0011334)3.40956634
39Potter facies (HP:0002009)3.40956634
40Posterior subcapsular cataract (HP:0007787)3.38291331
41Supraventricular arrhythmia (HP:0005115)3.29549952
42Abnormality of permanent molar morphology (HP:0011071)3.27256120
43Abnormality of the dental root (HP:0006486)3.27256120
44Taurodontia (HP:0000679)3.27256120
45Nausea (HP:0002018)3.25096850
46Decreased circulating renin level (HP:0003351)3.23353185
47Hemiparesis (HP:0001269)3.21281367
48Abnormality of vitamin B metabolism (HP:0004340)3.21203963
49Abnormality of aspartate family amino acid metabolism (HP:0010899)3.18006242
50Hyperactive renin-angiotensin system (HP:0000841)3.17646297
51Wide cranial sutures (HP:0010537)3.15338087
52Steatorrhea (HP:0002570)3.11987581
53Abdominal distention (HP:0003270)3.07088830
54Systemic lupus erythematosus (HP:0002725)3.06451926
55Nephrolithiasis (HP:0000787)3.06131351
56Abnormality of molar (HP:0011077)3.05819023
57Abnormality of molar morphology (HP:0011070)3.05819023
58Aplasia involving bones of the upper limbs (HP:0009823)3.04271580
59Aplasia of the phalanges of the hand (HP:0009802)3.04271580
60Aplasia involving bones of the extremities (HP:0009825)3.04271580
61Enlarged epiphyses (HP:0010580)3.00581861
62Nonprogressive disorder (HP:0003680)2.97818800
63Arterial tortuosity (HP:0005116)2.95446808
64Oligomenorrhea (HP:0000876)2.94603020
65Alkalosis (HP:0001948)2.88346849
66Abnormality of the dental pulp (HP:0006479)2.83900176
67Thin bony cortex (HP:0002753)2.83113317
68Abnormality of the middle phalanges of the toes (HP:0010183)2.82977679
69Hypolipoproteinemia (HP:0010981)2.82393718
70Spinal muscular atrophy (HP:0007269)2.77423547
71Dysautonomia (HP:0002459)2.77028935
72Aplasia/Hypoplasia affecting the retina (HP:0008061)2.75159668
73Protuberant abdomen (HP:0001538)2.72142463
74Vascular tortuosity (HP:0004948)2.71878851
75Abnormality of renin-angiotensin system (HP:0000847)2.70733733
76Abnormality of vitamin metabolism (HP:0100508)2.69202285
77Megaloblastic anemia (HP:0001889)2.68877040
78White forelock (HP:0002211)2.68513790
79Aplasia/Hypoplasia of the macula (HP:0008059)2.64594604
80Urethral obstruction (HP:0000796)2.64491857
81Hyperphosphaturia (HP:0003109)2.62481228
82Hyperuricemia (HP:0002149)2.61891638
83Increased purine levels (HP:0004368)2.61891638
84Patchy hypopigmentation of hair (HP:0011365)2.61131205
85Abnormality of incisor morphology (HP:0011063)2.58620735
86Abnormal urine phosphate concentration (HP:0012599)2.57243375
87Hypopigmentation of the fundus (HP:0007894)2.57205828
88Hand muscle atrophy (HP:0009130)2.55094317
89Hypoplasia of the uterus (HP:0000013)2.52073859
90Xanthomatosis (HP:0000991)2.52003123
91Bilateral microphthalmos (HP:0007633)2.47639512
92Paraplegia (HP:0010550)2.46934869
93Delayed epiphyseal ossification (HP:0002663)2.45651301
94Neonatal short-limb short stature (HP:0008921)2.45214228
95Hypophosphatemia (HP:0002148)2.43724252
96Villous atrophy (HP:0011473)2.42003301
97Abnormality of small intestinal villus morphology (HP:0011472)2.42003301
98Hypothermia (HP:0002045)2.40415654
99Distal lower limb muscle weakness (HP:0009053)2.39188789
100Epidermoid cyst (HP:0200040)2.38922887
101Obstructive sleep apnea (HP:0002870)2.38158107
102Tarsal synostosis (HP:0008368)2.37871415
103Abnormal glucose tolerance (HP:0001952)2.34643379
104Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.33413542
105Neurodegeneration (HP:0002180)2.31127317
106True hermaphroditism (HP:0010459)2.30897360
107Abnormality of purine metabolism (HP:0004352)2.29526687
108Hyperammonemia (HP:0001987)2.28577576
109Synostosis involving bones of the feet (HP:0009140)2.27110756
110Synostosis involving bones of the lower limbs (HP:0009138)2.27110756
111Abnormality of magnesium homeostasis (HP:0004921)2.26503958
112Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26284719
113Abnormal biliary tract morphology (HP:0012440)2.26003057
114Blue irides (HP:0000635)2.25704214
115Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23406809
116Carpal synostosis (HP:0009702)2.22239248
117Sleep apnea (HP:0010535)2.19747732
118Menorrhagia (HP:0000132)2.19552610
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19279123
120Poikilocytosis (HP:0004447)2.18850711
121Epiphyseal dysplasia (HP:0002656)2.17211684
122Abnormality of the costochondral junction (HP:0000919)2.17027122
123Subcapsular cataract (HP:0000523)2.16196965
124Chorioretinal atrophy (HP:0000533)2.14198424
125Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13771094
126Tubulointerstitial nephritis (HP:0001970)2.13589934
127Synostosis of carpal bones (HP:0005048)2.13563048
128Flat acetabular roof (HP:0003180)2.13500543
129Abnormality of sulfur amino acid metabolism (HP:0004339)2.13054206
130Increased circulating renin level (HP:0000848)2.12184466
131Abnormality of the aortic arch (HP:0012303)2.11847319
132Stomach cancer (HP:0012126)2.10510304
133Interstitial pulmonary disease (HP:0006530)2.08075914
134Enlarged kidneys (HP:0000105)2.04929030
135Abnormality of nucleobase metabolism (HP:0010932)2.04500860
136Metabolic acidosis (HP:0001942)2.03869219
137Abnormal autonomic nervous system physiology (HP:0012332)2.02676532
138Right ventricular cardiomyopathy (HP:0011663)2.02388234
139Scotoma (HP:0000575)2.01129642
140Upper limb amyotrophy (HP:0009129)2.00147959
141Distal upper limb amyotrophy (HP:0007149)2.00147959
142Ventricular fibrillation (HP:0001663)12.2453786
143Abnormality of glutamine family amino acid metabolism (HP:0010902)10.1951483
144Biliary tract neoplasm (HP:0100574)1.99550838
145Abnormality of renal excretion (HP:0011036)1.99349459
146Abnormality of the vitreous humor (HP:0004327)1.97463500
147Sudden cardiac death (HP:0001645)1.95748625
148Hyperventilation (HP:0002883)1.95384766
149Hypoplasia of dental enamel (HP:0006297)1.93408155
150Fetal akinesia sequence (HP:0001989)1.92489791
151Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91383841
152Focal segmental glomerulosclerosis (HP:0000097)1.90850542
153Hypoalphalipoproteinemia (HP:0003233)1.86354832
154Renal tubular acidosis (HP:0001947)1.86281090
155Abnormality of the nasal septum (HP:0000419)1.84982198
156Hypokalemia (HP:0002900)1.83709811
157Abnormal albumin level (HP:0012116)1.83524205
158Hypoalbuminemia (HP:0003073)1.83524205
159Abnormal pancreas size (HP:0012094)1.82945869
160Rhinitis (HP:0012384)1.82584538
161Annular pancreas (HP:0001734)1.78542015
162Pancreatitis (HP:0001733)1.78525903
163Hypocalcemia (HP:0002901)1.78153355
164Symptomatic seizures (HP:0011145)1.77834020
165Synostosis involving bones of the hand (HP:0004278)1.77010358
166Hypotension (HP:0002615)1.76341725
167Abnormality of the distal phalanges of the toes (HP:0010182)1.76246707
168Aplasia/hypoplasia of the uterus (HP:0008684)1.74439899
169Action tremor (HP:0002345)1.72844843
170Carpal bone hypoplasia (HP:0001498)1.71620010
171Long clavicles (HP:0000890)1.68648997
172Pancreatic fibrosis (HP:0100732)1.67541723
173Metaphyseal irregularity (HP:0003025)1.67080975
174Cerebral palsy (HP:0100021)1.66844864
175Petechiae (HP:0000967)1.65749603
176Lethargy (HP:0001254)1.64654851
177Hyperaldosteronism (HP:0000859)1.64301323
178Abnormality of the humerus (HP:0003063)1.64026390
179Renal tubular dysfunction (HP:0000124)1.63380891
180Abnormality of the lacrimal duct (HP:0011481)1.62744364
181Bifid scrotum (HP:0000048)1.62432651
182Intrahepatic cholestasis (HP:0001406)1.60116949
183Hyperparathyroidism (HP:0000843)1.59560154
184Irritability (HP:0000737)1.57624373
185Occipital encephalocele (HP:0002085)1.57292749
186Tetany (HP:0001281)1.57162167
187Abnormal respiratory motile cilium physiology (HP:0012261)1.56568337
188Hypophosphatemic rickets (HP:0004912)1.56539465
189Scanning speech (HP:0002168)1.56311556
190Abnormality of the upper arm (HP:0001454)1.55319560
191Abnormal urine output (HP:0012590)1.53908519
192Dicarboxylic aciduria (HP:0003215)1.53827041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.45925156
2STK396.58058633
3WNK45.07753809
4MST44.38161092
5GRK14.17394069
6FRK3.86080376
7RIPK12.77787017
8CAMKK12.46291443
9MAP3K102.26096822
10CAMKK22.17950773
11WNK12.10445510
12AKT32.01758849
13MAP3K21.97357648
14LMTK21.93474715
15TESK21.91757965
16STK101.86102751
17FGFR21.85842900
18TRPM71.71104672
19BMPR1B1.67631196
20EPHB21.67276202
21MST1R1.64348827
22MAP3K31.51606244
23WNK31.47375608
24NEK61.46260410
25ERN11.45929843
26SGK21.41414972
27MAP3K121.41101557
28PDK21.38366145
29TESK11.36846537
30PINK11.34706619
31EPHA31.31082069
32ERBB21.30573671
33GRK61.28869013
34PRPF4B1.21616510
35PRKCQ1.20793764
36PHKG11.18146581
37PHKG21.18146581
38JAK21.18115642
39SIK11.17831982
40EPHA41.17561030
41ERBB31.17540949
42DDR21.17344975
43MYLK1.17207445
44MAP3K141.13930283
45LRRK21.13593638
46BMPR21.11795034
47EPHA21.11762594
48PTK61.05724789
49SGK2231.04218724
50SGK4941.04218724
51TNIK1.01216612
52OXSR10.98577895
53FGFR30.96798591
54CDK80.96141632
55INSRR0.95147487
56EPHB10.92418689
57IRAK10.92100209
58SGK30.88923693
59MAP4K20.88012669
60PRKCE0.86854126
61BRSK20.85245819
62LIMK10.83560017
63MET0.82701323
64CSNK1A1L0.78985235
65CAMK40.77825660
66JAK10.75493721
67ZAK0.75164702
68GRK70.74802993
69TYK20.74766515
70PRKAA20.73390860
71TGFBR20.70717570
72CASK0.69146658
73MAP2K60.68758421
74STK38L0.66266359
75NLK0.65948906
76ADRBK20.65802858
77STK240.65580386
78MELK0.64647501
79PRKCZ0.64617657
80ITK0.64588358
81NUAK10.64554432
82CHUK0.63966787
83FER0.63652159
84PIM10.63203588
85MAPK150.61978298
86PRKACG0.61631484
87ROCK10.59971631
88CDK50.59568591
89CSNK1G10.59300310
90MAP3K10.59024163
91PRKCG0.58544088
92FGFR40.57785236
93SGK10.57287501
94TGFBR10.56715050
95PLK20.55986807
96RPS6KB10.55501536
97MATK0.55345532
98ROCK20.54379318
99PDGFRB0.53826222
100LATS10.52729315
101PKN20.52531835
102* PRKCA0.52503076
103AKT20.52321200
104CDK60.48744052
105MARK30.48305563
106PRKG20.47069630
107RET0.46656424
108PAK40.46562494
109MAPK40.45609425
110BMX0.45327471
111HIPK20.44748438
112MAP2K70.43671357
113RPS6KB20.43603120
114MAPK130.43492106
115PIK3CA0.43197325
116CAMK1D0.42024070
117PTK2B0.41659990
118DYRK1A0.41586718
119PDK10.41182180
120DYRK1B0.39949400
121TEC0.39485391
122OBSCN0.39456763
123GSK3A0.38358204
124CSNK1A10.38233205
125MAP3K70.37030573
126ALK0.36702393
127RIPK40.36533595
128FGFR10.36084383
129PRKG10.35824942
130MAP4K10.35641553
131NTRK30.34986102
132STK30.33914876
133PIK3CG0.33793278
134PKN10.32977440
135CAMK1G0.32582615
136* PRKACA0.32541209
137BTK0.32399509
138CSNK1G30.32322597
139CSF1R0.31439609
140MAP2K20.31119864
141CAMK2A0.31080764
142CDC42BPA0.29702632
143PDPK10.28979466
144SRC0.28628736
145ERBB40.28583700
146CAMK2D0.28258496
147NEK90.28181580
148PTK20.27982738
149STK110.27631033
150STK380.27378935
151PRKCH0.27329964
152PRKCB0.26581829
153ADRBK10.25746517
154IGF1R0.23816942
155PRKCD0.23309969
156TAOK30.21305377

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.02962798
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.67832556
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.40446104
4Fat digestion and absorption_Homo sapiens_hsa049754.35433528
5Renin-angiotensin system_Homo sapiens_hsa046144.33834048
6Starch and sucrose metabolism_Homo sapiens_hsa005003.23201108
7Gastric acid secretion_Homo sapiens_hsa049713.03410751
8* Protein digestion and absorption_Homo sapiens_hsa049742.69658019
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55814168
10Nitrogen metabolism_Homo sapiens_hsa009102.55037496
11Caffeine metabolism_Homo sapiens_hsa002322.48783667
12Mineral absorption_Homo sapiens_hsa049782.36536479
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.36005460
14Propanoate metabolism_Homo sapiens_hsa006402.32332804
15Linoleic acid metabolism_Homo sapiens_hsa005912.26331936
16Retinol metabolism_Homo sapiens_hsa008302.22609620
17Arginine biosynthesis_Homo sapiens_hsa002202.20190915
18Histidine metabolism_Homo sapiens_hsa003402.13267461
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08977628
20Tyrosine metabolism_Homo sapiens_hsa003502.06332471
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95158956
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92567834
23beta-Alanine metabolism_Homo sapiens_hsa004101.92345447
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.87424737
25Phenylalanine metabolism_Homo sapiens_hsa003601.73285666
26Bile secretion_Homo sapiens_hsa049761.64241376
27Sulfur metabolism_Homo sapiens_hsa009201.54719614
28Chemical carcinogenesis_Homo sapiens_hsa052041.51012102
29Fructose and mannose metabolism_Homo sapiens_hsa000511.47368476
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46825097
31Fatty acid elongation_Homo sapiens_hsa000621.42633158
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41338290
33Vitamin digestion and absorption_Homo sapiens_hsa049771.31582043
34Glycerolipid metabolism_Homo sapiens_hsa005611.27908426
35Oxidative phosphorylation_Homo sapiens_hsa001901.27321347
36Ether lipid metabolism_Homo sapiens_hsa005651.25764756
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21747955
38Complement and coagulation cascades_Homo sapiens_hsa046101.20745687
39Arginine and proline metabolism_Homo sapiens_hsa003301.18330006
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.17771200
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14814614
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14782356
43Butanoate metabolism_Homo sapiens_hsa006501.13765967
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13075095
45Inositol phosphate metabolism_Homo sapiens_hsa005621.04960648
46Arachidonic acid metabolism_Homo sapiens_hsa005901.00159297
47Galactose metabolism_Homo sapiens_hsa000520.97272863
48Regulation of autophagy_Homo sapiens_hsa041400.96307028
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.96034427
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93589145
51Glutathione metabolism_Homo sapiens_hsa004800.89721614
52Asthma_Homo sapiens_hsa053100.89625286
53Fatty acid metabolism_Homo sapiens_hsa012120.88532033
54Salivary secretion_Homo sapiens_hsa049700.88128895
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87852821
56Lysosome_Homo sapiens_hsa041420.85672106
57Peroxisome_Homo sapiens_hsa041460.81835501
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80504373
59Phagosome_Homo sapiens_hsa041450.77839937
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77446002
61Amphetamine addiction_Homo sapiens_hsa050310.75958011
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.75011162
63Prostate cancer_Homo sapiens_hsa052150.74386804
64Sphingolipid metabolism_Homo sapiens_hsa006000.72891177
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.72637769
66Fatty acid degradation_Homo sapiens_hsa000710.72005390
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71335341
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70281950
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69286544
70Alzheimers disease_Homo sapiens_hsa050100.68541008
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66745845
72Thyroid hormone synthesis_Homo sapiens_hsa049180.66340528
73Fatty acid biosynthesis_Homo sapiens_hsa000610.65759547
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64289217
75Cardiac muscle contraction_Homo sapiens_hsa042600.62263536
76Type II diabetes mellitus_Homo sapiens_hsa049300.62179053
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61413799
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60993365
79ABC transporters_Homo sapiens_hsa020100.59416264
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58511167
81Huntingtons disease_Homo sapiens_hsa050160.57856948
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57221317
83Parkinsons disease_Homo sapiens_hsa050120.56632691
84Vibrio cholerae infection_Homo sapiens_hsa051100.56079876
85Olfactory transduction_Homo sapiens_hsa047400.55370339
86Steroid biosynthesis_Homo sapiens_hsa001000.54723205
87Allograft rejection_Homo sapiens_hsa053300.54233071
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53254750
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51570424
90Melanogenesis_Homo sapiens_hsa049160.51332508
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51000209
92mTOR signaling pathway_Homo sapiens_hsa041500.50749771
93Autoimmune thyroid disease_Homo sapiens_hsa053200.48842985
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48574592
95Tryptophan metabolism_Homo sapiens_hsa003800.48137220
96Graft-versus-host disease_Homo sapiens_hsa053320.48008520
97Circadian entrainment_Homo sapiens_hsa047130.47706060
98Dilated cardiomyopathy_Homo sapiens_hsa054140.46244370
99ECM-receptor interaction_Homo sapiens_hsa045120.45123967
100Carbon metabolism_Homo sapiens_hsa012000.44427526
101Gap junction_Homo sapiens_hsa045400.43239108
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43030789
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41570316
104Synaptic vesicle cycle_Homo sapiens_hsa047210.40154026
105Type I diabetes mellitus_Homo sapiens_hsa049400.40036126
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39323174
107Staphylococcus aureus infection_Homo sapiens_hsa051500.37812426
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37782443
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37666817
110Cocaine addiction_Homo sapiens_hsa050300.37642138
111Insulin secretion_Homo sapiens_hsa049110.37279695
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36734940
113Calcium signaling pathway_Homo sapiens_hsa040200.36356271
114cAMP signaling pathway_Homo sapiens_hsa040240.36176084
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.35918602
116Folate biosynthesis_Homo sapiens_hsa007900.35586488
117Pancreatic secretion_Homo sapiens_hsa049720.33880348
118Collecting duct acid secretion_Homo sapiens_hsa049660.28867752
119Glucagon signaling pathway_Homo sapiens_hsa049220.28498276
120Renin secretion_Homo sapiens_hsa049240.27926908
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26756042
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26574606
123Metabolic pathways_Homo sapiens_hsa011000.26390911
124Prion diseases_Homo sapiens_hsa050200.25754897
125PPAR signaling pathway_Homo sapiens_hsa033200.25401572
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.24429422
127Serotonergic synapse_Homo sapiens_hsa047260.22114073
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.21714195
129Insulin resistance_Homo sapiens_hsa049310.19054394
130Antigen processing and presentation_Homo sapiens_hsa046120.18646614
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.14020477
132Pyruvate metabolism_Homo sapiens_hsa006200.13123550
133Tight junction_Homo sapiens_hsa045300.12979785
134Other glycan degradation_Homo sapiens_hsa005110.09085702
135Phototransduction_Homo sapiens_hsa047440.08251742
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.04608092
137Ovarian steroidogenesis_Homo sapiens_hsa049130.02185124
138African trypanosomiasis_Homo sapiens_hsa05143-0.0466133
139Pentose phosphate pathway_Homo sapiens_hsa00030-0.0415679
140AMPK signaling pathway_Homo sapiens_hsa04152-0.0324781
141Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0248156

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »