KCNJ14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phototransduction, visible light (GO:0007603)9.39661111
2phototransduction (GO:0007602)9.33636845
3detection of visible light (GO:0009584)9.23806255
4detection of light stimulus (GO:0009583)9.11393025
5GMP metabolic process (GO:0046037)9.03763959
6positive regulation of guanylate cyclase activity (GO:0031284)8.74490377
7protein-chromophore linkage (GO:0018298)8.46652904
8visual perception (GO:0007601)7.98077861
9sensory perception of light stimulus (GO:0050953)7.90382910
10regulation of guanylate cyclase activity (GO:0031282)7.89179140
11cellular response to light stimulus (GO:0071482)7.08449169
12photoreceptor cell differentiation (GO:0046530)6.46380343
13eye photoreceptor cell differentiation (GO:0001754)6.46380343
14detection of external stimulus (GO:0009581)6.43212170
15detection of abiotic stimulus (GO:0009582)6.30124442
16regulation of cGMP metabolic process (GO:0030823)5.90495535
17retina development in camera-type eye (GO:0060041)5.87256763
18protein K11-linked deubiquitination (GO:0035871)5.76868813
19positive regulation of cGMP biosynthetic process (GO:0030828)5.53622333
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.43664244
21regulation of cGMP biosynthetic process (GO:0030826)5.19313690
22behavioral response to nicotine (GO:0035095)5.13900348
23positive regulation of cGMP metabolic process (GO:0030825)4.87101717
24L-fucose catabolic process (GO:0042355)4.65464237
25fucose catabolic process (GO:0019317)4.65464237
26L-fucose metabolic process (GO:0042354)4.65464237
27receptor guanylyl cyclase signaling pathway (GO:0007168)4.65451685
28nonmotile primary cilium assembly (GO:0035058)4.61862084
29cellular response to radiation (GO:0071478)4.50791853
30adaptation of signaling pathway (GO:0023058)4.25577415
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.21953676
32detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.14499373
33regulation of voltage-gated calcium channel activity (GO:1901385)4.14385665
34cell morphogenesis involved in neuron differentiation (GO:0048667)4.06640424
35serotonin receptor signaling pathway (GO:0007210)4.01191344
36negative regulation of cytosolic calcium ion concentration (GO:0051481)3.94450310
37regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.93601536
38sulfation (GO:0051923)3.93257501
39protein localization to synapse (GO:0035418)3.84478373
40sensory perception (GO:0007600)3.77062242
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.70180518
42estrogen biosynthetic process (GO:0006703)3.68807572
43regulation of clathrin-mediated endocytosis (GO:2000369)3.68766658
44tryptophan catabolic process (GO:0006569)3.68721497
45indole-containing compound catabolic process (GO:0042436)3.68721497
46indolalkylamine catabolic process (GO:0046218)3.68721497
47response to pheromone (GO:0019236)3.64696742
48sodium ion export (GO:0071436)3.61518595
49response to light stimulus (GO:0009416)3.60886328
50regulation of short-term neuronal synaptic plasticity (GO:0048172)3.58982234
51neuron development (GO:0048666)3.51589009
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.48094312
53regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.45255616
54regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.45255616
55retina layer formation (GO:0010842)3.44895382
56indolalkylamine metabolic process (GO:0006586)3.44759472
57membrane hyperpolarization (GO:0060081)3.42362454
58prenylation (GO:0097354)3.41030706
59protein prenylation (GO:0018342)3.41030706
60piRNA metabolic process (GO:0034587)3.40827099
61cellular response to ATP (GO:0071318)3.40350590
62DNA deamination (GO:0045006)3.39860357
63negative regulation of receptor-mediated endocytosis (GO:0048261)3.31118536
64water-soluble vitamin biosynthetic process (GO:0042364)3.20796109
65positive regulation of sodium ion transmembrane transport (GO:1902307)3.20640011
66positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.20189530
67cellular ketone body metabolic process (GO:0046950)3.16172215
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15692284
69replication fork processing (GO:0031297)3.13832879
70cellular potassium ion homeostasis (GO:0030007)3.13612636
71protein-cofactor linkage (GO:0018065)3.13511530
72behavioral response to ethanol (GO:0048149)3.11179190
73phosphatidylinositol acyl-chain remodeling (GO:0036149)3.09855080
74potassium ion homeostasis (GO:0055075)3.09058672
75negative regulation of telomere maintenance (GO:0032205)3.07181508
76tryptophan metabolic process (GO:0006568)3.05142161
77negative regulation of Ras GTPase activity (GO:0034261)3.02309152
78CDP-diacylglycerol biosynthetic process (GO:0016024)3.02288734
79preassembly of GPI anchor in ER membrane (GO:0016254)3.01725573
80striatum development (GO:0021756)3.01451105
81response to histamine (GO:0034776)3.01423861
82thyroid hormone metabolic process (GO:0042403)3.00479786
83positive regulation of neurotransmitter transport (GO:0051590)3.00413333
84purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00260489
853-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00260489
86reflex (GO:0060004)2.99043262
87platelet dense granule organization (GO:0060155)2.97936454
88protein complex biogenesis (GO:0070271)2.97099805
89synaptic vesicle docking involved in exocytosis (GO:0016081)2.97015936
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96883871
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.96883871
92NADH dehydrogenase complex assembly (GO:0010257)2.96883871
93ketone body metabolic process (GO:1902224)2.96558092
94kynurenine metabolic process (GO:0070189)2.95691671
95regulation of appetite (GO:0032098)2.95203823
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94930572
97synaptic vesicle maturation (GO:0016188)2.94451985
98hematopoietic stem cell proliferation (GO:0071425)2.94236679
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93303415
100interferon-gamma production (GO:0032609)2.91182833
101regulation of cilium movement (GO:0003352)2.90383413
102startle response (GO:0001964)2.88555632
103axon ensheathment in central nervous system (GO:0032291)2.84246591
104central nervous system myelination (GO:0022010)2.84246591
105CDP-diacylglycerol metabolic process (GO:0046341)2.84073972
106short-term memory (GO:0007614)2.82603457
107glycerophospholipid catabolic process (GO:0046475)2.80743716
108negative regulation of mast cell activation (GO:0033004)2.80397189
109negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.79771411
110negative regulation of calcium ion transmembrane transport (GO:1903170)2.79771411
111rRNA catabolic process (GO:0016075)2.78563788
112recombinational repair (GO:0000725)2.77833390
113double-strand break repair via homologous recombination (GO:0000724)2.77496218
114nephron tubule morphogenesis (GO:0072078)2.77323481
115nephron epithelium morphogenesis (GO:0072088)2.77323481
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.76958394
117activated T cell proliferation (GO:0050798)2.76145005
118pseudouridine synthesis (GO:0001522)2.75985720
119negative regulation of circadian rhythm (GO:0042754)2.75592260
120neuronal action potential (GO:0019228)2.74376495
121retina homeostasis (GO:0001895)2.73998057
122negative regulation of calcium ion transport into cytosol (GO:0010523)2.72361535
123cornea development in camera-type eye (GO:0061303)2.71154438
124synaptic vesicle exocytosis (GO:0016079)2.70889564
125indole-containing compound metabolic process (GO:0042430)2.70813535
126mitochondrial respiratory chain complex assembly (GO:0033108)2.70700338
127DNA methylation involved in gamete generation (GO:0043046)2.70582457
128seminiferous tubule development (GO:0072520)2.70491853
129peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.70120334
130positive regulation of oligodendrocyte differentiation (GO:0048714)2.68951049
131negative regulation of cation channel activity (GO:2001258)2.67837036
132oxidative demethylation (GO:0070989)2.64696716
133mitochondrion transport along microtubule (GO:0047497)2.64357782
134establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64357782
135epithelial cilium movement (GO:0003351)2.63717271
136phosphatidylserine acyl-chain remodeling (GO:0036150)2.62780977
137cilium or flagellum-dependent cell motility (GO:0001539)2.62530754
138phospholipid translocation (GO:0045332)2.60628430
139lipid translocation (GO:0034204)2.60628430
140innervation (GO:0060384)2.59289762
141regulation of action potential (GO:0098900)2.58948662
142respiratory chain complex IV assembly (GO:0008535)2.57900868
143lactate metabolic process (GO:0006089)2.57456590
144protein import into peroxisome matrix (GO:0016558)2.57126081
145retinoid metabolic process (GO:0001523)2.56785400
146chemosensory behavior (GO:0007635)2.56278493
147regulation of synaptic vesicle exocytosis (GO:2000300)2.56232947
148amine catabolic process (GO:0009310)2.55113765
149cellular biogenic amine catabolic process (GO:0042402)2.55113765
150behavioral response to cocaine (GO:0048148)2.54351297
151DNA double-strand break processing (GO:0000729)2.53181393
152regulation of penile erection (GO:0060405)2.52280165
153detection of chemical stimulus involved in sensory perception (GO:0050907)2.51238284
154cilium morphogenesis (GO:0060271)2.50776337
155synaptic transmission, cholinergic (GO:0007271)2.50519239
156positive regulation of fatty acid transport (GO:2000193)2.49825211
157dopamine receptor signaling pathway (GO:0007212)2.49369449
158protein K63-linked deubiquitination (GO:0070536)2.49333570
159axoneme assembly (GO:0035082)2.49262409
160neural tube formation (GO:0001841)2.49031122
161sperm motility (GO:0030317)2.48605815
162protein K6-linked ubiquitination (GO:0085020)2.48413345
163negative regulation of DNA-dependent DNA replication (GO:2000104)2.48045808
164protein sumoylation (GO:0016925)2.47786771
165primary amino compound metabolic process (GO:1901160)2.47345311
166positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.46804746
167gamma-aminobutyric acid transport (GO:0015812)2.46397983
168multicellular organism reproduction (GO:0032504)2.46319815
169regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.46264026
170protein polyglutamylation (GO:0018095)2.46180550
171synaptic vesicle endocytosis (GO:0048488)2.45971716
172tRNA modification (GO:0006400)2.45871528
173cell communication by electrical coupling (GO:0010644)2.45677502
174regulation of neurotransmitter uptake (GO:0051580)2.44372230
175response to radiation (GO:0009314)2.43352940
176detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.41124432
177positive regulation of cyclase activity (GO:0031281)2.40771167
178regulation of rhodopsin mediated signaling pathway (GO:0022400)16.5546064
179rhodopsin mediated signaling pathway (GO:0016056)16.2961761
180retinal cone cell development (GO:0046549)13.9378101
181detection of light stimulus involved in sensory perception (GO:0050962)11.7542850
182detection of light stimulus involved in visual perception (GO:0050908)11.7542850
183photoreceptor cell development (GO:0042461)11.0374462
184photoreceptor cell maintenance (GO:0045494)10.8557714
185eye photoreceptor cell development (GO:0042462)10.5356304
186retinal rod cell development (GO:0046548)10.0268475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.63019129
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.62099207
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.37738934
4EZH2_22144423_ChIP-Seq_EOC_Human3.15766948
5GBX2_23144817_ChIP-Seq_PC3_Human3.01543672
6DROSHA_22980978_ChIP-Seq_HELA_Human2.71538822
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70467138
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50292346
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.46007162
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45927978
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43642202
12VDR_22108803_ChIP-Seq_LS180_Human2.43489954
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.28893820
14TAF15_26573619_Chip-Seq_HEK293_Human2.28469368
15AR_21572438_ChIP-Seq_LNCaP_Human2.24299536
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17974699
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15079274
18REST_21632747_ChIP-Seq_MESCs_Mouse2.12484670
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.12274851
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09693455
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05600773
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.03881837
23FUS_26573619_Chip-Seq_HEK293_Human2.02089599
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01984227
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.01455974
26EWS_26573619_Chip-Seq_HEK293_Human1.95363553
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91140751
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86911188
29P53_22127205_ChIP-Seq_FIBROBLAST_Human1.85140061
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80598788
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80005828
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77410845
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76725790
34SMAD3_21741376_ChIP-Seq_HESCs_Human1.74881171
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74820054
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.74420181
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74217969
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73387912
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73387912
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.71246852
41TP53_22573176_ChIP-Seq_HFKS_Human1.68703382
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67370066
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.62992056
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62871948
45AR_19668381_ChIP-Seq_PC3_Human1.62206336
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57337875
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52052066
48KDM2B_26808549_Chip-Seq_K562_Human1.50578045
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50521190
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.49532354
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48911978
52IRF1_19129219_ChIP-ChIP_H3396_Human1.48745966
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47850635
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.47716529
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46926075
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46219790
57IGF1R_20145208_ChIP-Seq_DFB_Human1.45574288
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40869897
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40869897
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39676787
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.39391312
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39372498
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.39357570
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38677692
65SMAD4_21799915_ChIP-Seq_A2780_Human1.37173904
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.37016836
67MYC_18940864_ChIP-ChIP_HL60_Human1.36984768
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36673225
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.35638787
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34659641
71* FOXA1_25329375_ChIP-Seq_VCAP_Human1.33340127
72* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33340127
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31264941
74CTCF_27219007_Chip-Seq_Bcells_Human1.30820808
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29158915
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28833638
77TCF4_22108803_ChIP-Seq_LS180_Human1.27351642
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27279693
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23155344
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22445636
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.22214963
82SMC4_20622854_ChIP-Seq_HELA_Human1.21929008
83NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.21331357
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20473459
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19901881
86RNF2_27304074_Chip-Seq_NSC_Mouse1.19760515
87SOX2_19829295_ChIP-Seq_ESCs_Human1.19372981
88NANOG_19829295_ChIP-Seq_ESCs_Human1.19372981
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17557505
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.17239585
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17095432
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.16842823
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16290504
94* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14114999
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13959052
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.13942579
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13325908
98RUNX2_22187159_ChIP-Seq_PCA_Human1.13070801
99ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12941987
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.12850819
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12797916
102STAT3_23295773_ChIP-Seq_U87_Human1.12753166
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12744011
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12528874
105AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12281849
106CBP_21632823_ChIP-Seq_H3396_Human1.11961437
107ERA_21632823_ChIP-Seq_H3396_Human1.11405406
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11371822
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11178330
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.11087900
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10685768
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10133958
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.10077291
114EED_16625203_ChIP-ChIP_MESCs_Mouse1.10018709
115TBL1_22424771_ChIP-Seq_293T_Human1.09631115
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.09213843
117TCF4_18268006_ChIP-ChIP_LS174T_Human1.08995040
118EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08949282
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08491197
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.07809668
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07462593
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06054792
123AR_20517297_ChIP-Seq_VCAP_Human1.04219669
124TP53_16413492_ChIP-PET_HCT116_Human1.03717324
125MYC_19829295_ChIP-Seq_ESCs_Human1.03663971
126KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03085543
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02821403
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02570590
129WDR5_24793694_ChIP-Seq_LNCAP_Human1.02563488
130CDX2_22108803_ChIP-Seq_LS180_Human1.01372910
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00964632
132* HOXB7_26014856_ChIP-Seq_BT474_Human1.00756313
133* P68_20966046_ChIP-Seq_HELA_Human1.00505423
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00307715
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00142801
136P300_19829295_ChIP-Seq_ESCs_Human0.99076173
137ISL1_27105846_Chip-Seq_CPCs_Mouse0.98968962
138BCAT_22108803_ChIP-Seq_LS180_Human0.98515611
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.98407577
140FOXH1_21741376_ChIP-Seq_EPCs_Human0.98283841
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97952258
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97241141
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97081262
144NANOG_20526341_ChIP-Seq_ESCs_Human0.96856767
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96480791
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96351602
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96257558
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.95573157
149EGR1_19032775_ChIP-ChIP_M12_Human0.94873435
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93576285
151TCF4_23295773_ChIP-Seq_U87_Human0.92042290
152AR_25329375_ChIP-Seq_VCAP_Human0.91991342
153NCOR_22424771_ChIP-Seq_293T_Human0.91721289
154CREB1_26743006_Chip-Seq_LNCaP_Human0.91568677
155CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91537040
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91356143
157CBP_20019798_ChIP-Seq_JUKART_Human0.91356143
158SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91284392
159EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90618580
160DPY_21335234_ChIP-Seq_ESCs_Mouse0.90370547
161NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90220417
162EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88660418
163OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88268770
164ER_23166858_ChIP-Seq_MCF-7_Human0.88124925
165LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87784533
166* SOX2_21211035_ChIP-Seq_LN229_Gbm0.87073708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.50707289
2MP0005253_abnormal_eye_physiology6.49419648
3MP0006072_abnormal_retinal_apoptosis6.31159544
4MP0003950_abnormal_plasma_membrane4.14124363
5MP0005195_abnormal_posterior_eye3.74313514
6MP0002090_abnormal_vision3.48316230
7MP0001324_abnormal_eye_pigmentation3.40761907
8MP0000566_synostosis3.09008320
9MP0005391_vision/eye_phenotype3.08962259
10MP0002638_abnormal_pupillary_reflex2.67020184
11MP0005423_abnormal_somatic_nervous2.59456965
12MP0008875_abnormal_xenobiotic_pharmacok2.47906242
13MP0003195_calcinosis2.47291504
14MP0002229_neurodegeneration2.46997351
15MP0003136_yellow_coat_color2.43007151
16MP0002138_abnormal_hepatobiliary_system2.16865585
17MP0002736_abnormal_nociception_after2.13209590
18MP0002876_abnormal_thyroid_physiology2.05124865
19MP0003011_delayed_dark_adaptation10.1317768
20MP0001919_abnormal_reproductive_system1.96362900
21MP0008877_abnormal_DNA_methylation1.92798256
22MP0005389_reproductive_system_phenotype1.91282998
23MP0005174_abnormal_tail_pigmentation1.90175935
24MP0002752_abnormal_somatic_nervous1.89805681
25MP0001764_abnormal_homeostasis1.88604368
26MP0004233_abnormal_muscle_weight1.81708124
27MP0001986_abnormal_taste_sensitivity1.80809198
28MP0008872_abnormal_physiological_respon1.77628669
29MP0001984_abnormal_olfaction1.75197059
30MP0000372_irregular_coat_pigmentation1.73075886
31MP0006276_abnormal_autonomic_nervous1.70926040
32MP0005645_abnormal_hypothalamus_physiol1.68435023
33MP0005646_abnormal_pituitary_gland1.66314256
34MP0002102_abnormal_ear_morphology1.66184371
35MP0001485_abnormal_pinna_reflex1.60917967
36MP0000569_abnormal_digit_pigmentation1.60446828
37MP0002160_abnormal_reproductive_system1.58677545
38MP0002735_abnormal_chemical_nociception1.57019098
39MP0002254_reproductive_system_inflammat1.56011711
40MP0005084_abnormal_gallbladder_morpholo1.52040262
41MP0005171_absent_coat_pigmentation1.49021573
42MP0003787_abnormal_imprinting1.45834337
43MP0002938_white_spotting1.38041181
44MP0002882_abnormal_neuron_morphology1.37100685
45MP0002653_abnormal_ependyma_morphology1.32254833
46MP0000383_abnormal_hair_follicle1.31874036
47MP0001502_abnormal_circadian_rhythm1.30179422
48MP0004215_abnormal_myocardial_fiber1.28358282
49MP0002332_abnormal_exercise_endurance1.27285755
50MP0002163_abnormal_gland_morphology1.26791667
51MP0002928_abnormal_bile_duct1.26510863
52MP0004133_heterotaxia1.23290920
53MP0005310_abnormal_salivary_gland1.23187443
54MP0005377_hearing/vestibular/ear_phenot1.22979648
55MP0003878_abnormal_ear_physiology1.22979648
56MP0000427_abnormal_hair_cycle1.20679767
57MP0001501_abnormal_sleep_pattern1.19769981
58MP0004019_abnormal_vitamin_homeostasis1.17375841
59MP0004147_increased_porphyrin_level1.16823815
60MP0005379_endocrine/exocrine_gland_phen1.11814490
61MP0001905_abnormal_dopamine_level1.10545555
62MP0010386_abnormal_urinary_bladder1.08746645
63MP0001664_abnormal_digestion1.05990443
64MP0001486_abnormal_startle_reflex1.03910713
65MP0002210_abnormal_sex_determination1.02937352
66MP0002557_abnormal_social/conspecific_i1.01966519
67MP0002095_abnormal_skin_pigmentation0.99276190
68MP0005394_taste/olfaction_phenotype0.96980805
69MP0005499_abnormal_olfactory_system0.96980805
70MP0005410_abnormal_fertilization0.96046582
71MP0003718_maternal_effect0.95995421
72MP0002277_abnormal_respiratory_mucosa0.95460586
73MP0008058_abnormal_DNA_repair0.94764971
74MP0004084_abnormal_cardiac_muscle0.93829310
75MP0002751_abnormal_autonomic_nervous0.92452765
76MP0000230_abnormal_systemic_arterial0.91377414
77MP0005248_abnormal_Harderian_gland0.90645929
78MP0003880_abnormal_central_pattern0.90338044
79MP0002127_abnormal_cardiovascular_syste0.87514008
80MP0003698_abnormal_male_reproductive0.85893217
81MP0004782_abnormal_surfactant_physiolog0.85625742
82MP0005197_abnormal_uvea_morphology0.85460604
83MP0003937_abnormal_limbs/digits/tail_de0.85415032
84MP0004885_abnormal_endolymph0.85392486
85MP0005332_abnormal_amino_acid0.85321852
86MP0002272_abnormal_nervous_system0.85214031
87MP0006292_abnormal_olfactory_placode0.84876123
88MP0002733_abnormal_thermal_nociception0.84859388
89MP0003634_abnormal_glial_cell0.82263366
90MP0001663_abnormal_digestive_system0.81956290
91MP0008789_abnormal_olfactory_epithelium0.80299934
92MP0004270_analgesia0.79910431
93MP0004145_abnormal_muscle_electrophysio0.79380330
94MP0000778_abnormal_nervous_system0.79173772
95MP0001529_abnormal_vocalization0.78081942
96MP0002734_abnormal_mechanical_nocicepti0.76458440
97MP0000751_myopathy0.75652866
98MP0008775_abnormal_heart_ventricle0.70530882
99MP0002064_seizures0.69981705
100MP0004036_abnormal_muscle_relaxation0.69920715
101MP0003635_abnormal_synaptic_transmissio0.69789223
102MP0003646_muscle_fatigue0.66091242
103MP0003137_abnormal_impulse_conducting0.66029090
104MP0004859_abnormal_synaptic_plasticity0.64881762
105MP0009046_muscle_twitch0.64229339
106MP0005620_abnormal_muscle_contractility0.60460544
107MP0005187_abnormal_penis_morphology0.58300798
108MP0001346_abnormal_lacrimal_gland0.56973496
109MP0002067_abnormal_sensory_capabilities0.56836491
110MP0004085_abnormal_heartbeat0.56036158
111MP0002063_abnormal_learning/memory/cond0.54796079
112MP0005330_cardiomyopathy0.52221170
113MP0001963_abnormal_hearing_physiology0.49306968
114MP0000749_muscle_degeneration0.46999633
115MP0005670_abnormal_white_adipose0.46153116
116MP0005376_homeostasis/metabolism_phenot0.44683920
117MP0002572_abnormal_emotion/affect_behav0.44375897
118MP0005386_behavior/neurological_phenoty0.43923601
119MP0004924_abnormal_behavior0.43923601
120MP0005595_abnormal_vascular_smooth0.43702160
121MP0010030_abnormal_orbit_morphology0.42870580
122MP0001661_extended_life_span0.42336893
123MP0009745_abnormal_behavioral_response0.42274738
124MP0001286_abnormal_eye_development0.41481048
125MP0008569_lethality_at_weaning0.41462493
126MP0001968_abnormal_touch/_nociception0.40105289
127MP0000631_abnormal_neuroendocrine_gland0.39402882
128MP0002909_abnormal_adrenal_gland0.38557822
129MP0002184_abnormal_innervation0.37928397
130MP0004142_abnormal_muscle_tone0.36028447
131MP0002837_dystrophic_cardiac_calcinosis0.34291534
132MP0002972_abnormal_cardiac_muscle0.33324981
133MP0004043_abnormal_pH_regulation0.32002383
134MP0004130_abnormal_muscle_cell0.31947698
135MP0002108_abnormal_muscle_morphology0.30755779
136MP0008961_abnormal_basal_metabolism0.30524603
137MP0003045_fibrosis0.30162569
138MP0002269_muscular_atrophy0.29041982
139MP0002234_abnormal_pharynx_morphology0.28987744
140MP0004087_abnormal_muscle_fiber0.28654537
141MP0002066_abnormal_motor_capabilities/c0.28586847
142MP0002152_abnormal_brain_morphology0.28496429
143MP0008004_abnormal_stomach_pH0.28446707
144MP0005266_abnormal_metabolism0.27935604
145MP0004811_abnormal_neuron_physiology0.25300707
146MP0010368_abnormal_lymphatic_system0.25172834
147MP0000026_abnormal_inner_ear0.25095273
148MP0000747_muscle_weakness0.24472381
149MP0000465_gastrointestinal_hemorrhage0.24414751
150MP0000759_abnormal_skeletal_muscle0.24292559
151MP0000013_abnormal_adipose_tissue0.23530453
152MP0001970_abnormal_pain_threshold0.22616092
153MP0003633_abnormal_nervous_system0.22395041
154MP0002697_abnormal_eye_size0.22195807
155MP0004742_abnormal_vestibular_system0.20921976
156MP0000955_abnormal_spinal_cord0.20397866

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.76641800
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.17149958
3Central scotoma (HP:0000603)9.14440059
4Pigmentary retinal degeneration (HP:0001146)8.41775080
5Abnormality of macular pigmentation (HP:0008002)8.20500326
6Chorioretinal atrophy (HP:0000533)8.12653343
7Scotoma (HP:0000575)7.93093582
8Attenuation of retinal blood vessels (HP:0007843)7.62863528
9Dyschromatopsia (HP:0007641)7.56850005
10Pendular nystagmus (HP:0012043)7.03869961
11Decreased central vision (HP:0007663)6.13687120
12Abolished electroretinogram (ERG) (HP:0000550)6.00185667
13Type II diabetes mellitus (HP:0005978)5.48999696
14Photophobia (HP:0000613)5.45548303
15Keratoconus (HP:0000563)5.11150831
16Increased corneal curvature (HP:0100692)5.11150831
17Severe visual impairment (HP:0001141)4.86627989
18Cone-rod dystrophy (HP:0000548)4.55052181
19Macular degeneration (HP:0000608)4.47062049
20Choroideremia (HP:0001139)4.46687220
21Retinitis pigmentosa (HP:0000510)4.34080057
22Vitreoretinal degeneration (HP:0000655)4.28946041
23Constricted visual fields (HP:0001133)4.19426872
24Posterior subcapsular cataract (HP:0007787)4.06221003
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.60881644
26Nephronophthisis (HP:0000090)3.44847265
27Large for gestational age (HP:0001520)3.05048505
28Abnormality of the renal medulla (HP:0100957)3.03150560
29Progressive visual loss (HP:0000529)3.01079247
30Abnormal drinking behavior (HP:0030082)2.99802734
31Polydipsia (HP:0001959)2.99802734
32Retinal atrophy (HP:0001105)2.95500768
33Abnormality of the renal cortex (HP:0011035)2.94482080
34Chronic hepatic failure (HP:0100626)2.93558403
35Congenital sensorineural hearing impairment (HP:0008527)2.73085873
36Decreased circulating renin level (HP:0003351)2.71550334
37Tubular atrophy (HP:0000092)2.70799338
38Type II lissencephaly (HP:0007260)2.70375247
39Hyperventilation (HP:0002883)2.65173043
40Optic disc pallor (HP:0000543)2.64702036
41Subcapsular cataract (HP:0000523)2.58946168
42Duplicated collecting system (HP:0000081)2.54730439
43Abnormality of the renal collecting system (HP:0004742)2.53633911
44Wide nasal bridge (HP:0000431)2.46363617
45Polyuria (HP:0000103)2.45874589
46Abnormality of alanine metabolism (HP:0010916)2.43548472
47Hyperalaninemia (HP:0003348)2.43548472
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43548472
49Gait imbalance (HP:0002141)2.40313730
50Male pseudohermaphroditism (HP:0000037)2.38406657
51Congenital primary aphakia (HP:0007707)2.36949014
52Severe muscular hypotonia (HP:0006829)2.29751442
53Bile duct proliferation (HP:0001408)2.25528167
54Abnormal biliary tract physiology (HP:0012439)2.25528167
55Broad-based gait (HP:0002136)2.17494833
56Aplasia/hypoplasia of the uterus (HP:0008684)2.12832918
57Nephrogenic diabetes insipidus (HP:0009806)2.10127931
58Hypoplasia of the uterus (HP:0000013)2.09906315
59Furrowed tongue (HP:0000221)2.07557048
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.07215984
61Congenital hepatic fibrosis (HP:0002612)2.05036642
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.04450669
63Absent thumb (HP:0009777)2.03876018
64Rib fusion (HP:0000902)2.02933663
65Medial flaring of the eyebrow (HP:0010747)2.01958724
66Congenital, generalized hypertrichosis (HP:0004540)2.01458009
67Congenital stationary night blindness (HP:0007642)15.9329922
68Bony spicule pigmentary retinopathy (HP:0007737)11.9263309
69Mitochondrial inheritance (HP:0001427)1.98735970
70Absent speech (HP:0001344)1.96544494
71Patellar aplasia (HP:0006443)1.95852777
72Anencephaly (HP:0002323)1.95791531
73Gaze-evoked nystagmus (HP:0000640)1.94874577
74Aplasia/Hypoplasia of the patella (HP:0006498)1.94427345
75Abnormal urine output (HP:0012590)1.93322960
76Aplasia/Hypoplasia of the tibia (HP:0005772)1.90855185
77Dynein arm defect of respiratory motile cilia (HP:0012255)1.90309366
78Absent/shortened dynein arms (HP:0200106)1.90309366
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89803679
80Increased CSF lactate (HP:0002490)1.89539546
81Clubbing of toes (HP:0100760)1.89140327
82Small hand (HP:0200055)1.88086040
83Inability to walk (HP:0002540)1.87839444
84Optic nerve hypoplasia (HP:0000609)1.87560339
85Hepatocellular necrosis (HP:0001404)1.86717944
86Renal cortical cysts (HP:0000803)1.86048422
87Neoplasm of the adrenal cortex (HP:0100641)1.85509579
88Poor coordination (HP:0002370)1.85461469
89Abnormal pancreas size (HP:0012094)1.83416865
90Abnormal number of erythroid precursors (HP:0012131)1.81632788
91Asplenia (HP:0001746)1.81233780
92Progressive inability to walk (HP:0002505)1.80286346
93Hemiparesis (HP:0001269)1.78977837
94Postaxial foot polydactyly (HP:0001830)1.78045600
95Mesangial abnormality (HP:0001966)1.75456838
96Acute necrotizing encephalopathy (HP:0006965)1.74709694
97Abnormality of renal excretion (HP:0011036)1.74440931
98Epileptic encephalopathy (HP:0200134)1.73730626
99Stomach cancer (HP:0012126)1.73500650
100Hepatic necrosis (HP:0002605)1.72912946
101Hypoplasia of the pons (HP:0012110)1.72865929
102Abnormal respiratory motile cilium morphology (HP:0005938)1.72591683
103Abnormal respiratory epithelium morphology (HP:0012253)1.72591683
104Lissencephaly (HP:0001339)1.72466341
105Abnormality of the ileum (HP:0001549)1.72047427
106Abnormality of the pons (HP:0007361)1.71607951
107Tachypnea (HP:0002789)1.70579579
108Optic atrophy (HP:0000648)1.64188720
109Febrile seizures (HP:0002373)1.63542335
110Dysdiadochokinesis (HP:0002075)1.63378762
111Vaginal atresia (HP:0000148)1.58173154
112Severe Myopia (HP:0011003)1.54444569
113Hypoplasia of the fovea (HP:0007750)1.53739359
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.53739359
115Genital tract atresia (HP:0001827)1.52668787
116Prolonged QT interval (HP:0001657)1.49535355
117Horizontal nystagmus (HP:0000666)1.47967804
118Abnormality of the fovea (HP:0000493)1.47237112
119Polar cataract (HP:0010696)1.40038066
120Septo-optic dysplasia (HP:0100842)1.31246670
121Aplasia/Hypoplasia of the lens (HP:0008063)1.31151069
122Left ventricular hypertrophy (HP:0001712)1.31037415
123Albinism (HP:0001022)1.30845675
124Interstitial pulmonary disease (HP:0006530)1.30700160
125Retinal detachment (HP:0000541)1.29241871
126Astigmatism (HP:0000483)1.27104320
127True hermaphroditism (HP:0010459)1.21746600
128Progressive cerebellar ataxia (HP:0002073)1.21653442
129Chorioretinal coloboma (HP:0000567)1.15693806
130Visual hallucinations (HP:0002367)1.15368604
131Syncope (HP:0001279)1.14729379
132Truncal ataxia (HP:0002078)1.12550785
133Abnormal EKG (HP:0003115)1.12159689
134Atrial fibrillation (HP:0005110)1.09819812
135Pancreatic fibrosis (HP:0100732)1.09815941
136Aplasia/Hypoplasia of the macula (HP:0008059)1.06734209
137Broad foot (HP:0001769)1.02986980
138Specific learning disability (HP:0001328)0.99738088
139Primary atrial arrhythmia (HP:0001692)0.99644142
140Aplasia/Hypoplasia affecting the retina (HP:0008061)0.99152398
141Genetic anticipation (HP:0003743)0.97699195
142Supraventricular tachycardia (HP:0004755)0.94762185
143Cholecystitis (HP:0001082)0.92161492
144Abnormal gallbladder physiology (HP:0012438)0.92161492
145Supraventricular arrhythmia (HP:0005115)0.91663830
146Aplasia/Hypoplasia of the tongue (HP:0010295)0.91055103
147Exercise-induced muscle cramps (HP:0003710)0.90345729
148Dysmetric saccades (HP:0000641)0.87603283
149Ventricular fibrillation (HP:0001663)0.87222528
150Pancreatic cysts (HP:0001737)0.86117930
151Asthma (HP:0002099)0.84544379
152Myoglobinuria (HP:0002913)0.84450407
153Decreased testicular size (HP:0008734)0.83634311
154Molar tooth sign on MRI (HP:0002419)0.81895042
155Abnormality of midbrain morphology (HP:0002418)0.81895042
156Abnormality of dental color (HP:0011073)0.81620330
157Cystic liver disease (HP:0006706)0.81610889
158Cerebellar dysplasia (HP:0007033)0.81134124
159Hypermetropia (HP:0000540)0.80709726
160Sclerocornea (HP:0000647)0.80593441
161Hypoventilation (HP:0002791)0.79786709
162Pheochromocytoma (HP:0002666)0.79224427
163Abnormality of the parathyroid morphology (HP:0011766)0.77917398
164Recurrent sinusitis (HP:0011108)0.75485765
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.75374475
166Depression (HP:0000716)0.74933823
167Exercise-induced myalgia (HP:0003738)0.74213789
168Partial agenesis of the corpus callosum (HP:0001338)0.71276953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.30609279
2PBK5.38441718
3MKNK25.04789460
4WNK34.18480407
5PINK13.07293269
6ADRBK22.93135289
7BMPR1B2.82031421
8MKNK12.74601889
9ZAK2.68013942
10MAP4K22.45953840
11WNK42.41686300
12IRAK22.11550752
13TXK2.10893812
14NEK12.04422089
15PAK62.00127858
16GRK110.5240240
17TLK11.91575400
18NUAK11.84086568
19MAP3K41.77487247
20STK381.71577687
21PHKG11.68260575
22PHKG21.68260575
23MAPK131.62664025
24SIK21.61738311
25ACVR1B1.59606887
26STK391.59411627
27CAMK1D1.56802059
28CAMK1G1.55332339
29INSRR1.53485023
30MARK11.43408286
31CASK1.43104089
32BRD41.30860117
33ADRBK11.30010578
34TAOK11.29275609
35MAPK151.25414070
36OXSR11.25231440
37DYRK1A1.23742849
38SGK2231.21520567
39SGK4941.21520567
40MAPK121.19490880
41DYRK21.17837872
42MAP3K111.13265875
43PRPF4B1.12537268
44TNIK1.08403665
45CDK121.07765893
46MAPKAPK31.06496812
47PRKD31.06267421
48TAOK21.05342248
49CAMKK11.02543817
50MAPK71.00294168
51CAMK2D0.98581578
52SGK20.96786626
53LMTK20.96593200
54PRKCZ0.96033978
55MINK10.95726027
56CSNK1D0.93107178
57HIPK20.92697477
58PRKAA10.92513781
59ICK0.91447364
60TGFBR10.89817261
61LATS10.88778864
62NEK20.88298547
63RPS6KA40.87659034
64PRKCQ0.84564607
65TNK20.84540324
66MAP3K70.84301863
67PRKCH0.84168305
68WNK10.83281404
69VRK10.81427612
70MAP3K30.80504038
71SGK30.80361296
72DAPK20.80120797
73IRAK10.79353469
74VRK20.77432938
75MAPKAPK50.77068087
76STK38L0.76990535
77FES0.75640103
78PRKCE0.72850210
79MAP3K100.72365641
80CAMK10.71250942
81PLK40.71237527
82STK160.71182447
83NTRK30.70822518
84TAOK30.70510367
85ABL20.70387481
86MYLK0.68352566
87TTN0.66504252
88PRKACG0.66228660
89PRKAA20.65927652
90CDK30.65856892
91NME10.63449771
92RPS6KA30.63295720
93PRKCB0.62923574
94TAF10.62335298
95SIK10.60868103
96CSNK1G20.60168109
97GRK50.60097605
98IKBKB0.59175591
99CAMKK20.59089792
100MAP2K70.59035273
101AKT30.58923344
102BCKDK0.57901396
103CDK50.57150337
104NTRK20.56198676
105PNCK0.56011294
106FGFR20.53435226
107WEE10.52917094
108CAMK40.52739018
109CCNB10.52001719
110MUSK0.51879408
111TIE10.51748230
112CAMK2A0.51539619
113PRKCG0.51445791
114MAPK100.50989445
115PLK30.50046477
116GSK3B0.49835922
117CSNK1G30.49656232
118ERBB20.49630930
119MAP3K90.49549802
120CDK90.49399738
121TTK0.49386082
122CSNK1A10.49070065
123PKN10.48523788
124CSNK1G10.47883576
125MAP2K40.47469343
126PDK20.46946492
127PRKACA0.46222521
128MAPK90.42719229
129PIK3CA0.41125366
130AKT20.41062820
131SGK10.40700735
132MAPK140.39785040
133PLK20.39599979
134PRKD20.39251486
135FER0.37630518
136PRKCI0.37184535
137TRIM280.37043493
138PTK2B0.36981363
139PRKDC0.36886250
140MAP2K60.36766232
141PRKCA0.36686992
142CSNK1A1L0.36378166
143CHUK0.35790311
144STK240.35488862
145EPHA40.34717900
146CDK150.34702863
147STK110.34167153
148CHEK20.34066761
149CDC42BPA0.33427438
150PRKG10.32732997
151PAK30.31030083
152CDK11A0.30596667
153PRKACB0.30591289
154CDK180.30499567
155CDK10.30325328
156RPS6KA50.29556524
157FLT30.29179554
158CDK140.28971687
159MAPK80.28634298
160MST40.28564827
161PRKD10.28384948
162TEC0.26145579
163BRSK20.25321726
164MAP2K30.24293002
165KIT0.24087061
166PLK10.23677733

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.69548696
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68237949
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34430082
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33257861
5Butanoate metabolism_Homo sapiens_hsa006502.24116548
6RNA polymerase_Homo sapiens_hsa030202.19978862
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18193283
8Oxidative phosphorylation_Homo sapiens_hsa001902.14599510
9Selenocompound metabolism_Homo sapiens_hsa004502.12884595
10Phototransduction_Homo sapiens_hsa0474415.1702162
11Synaptic vesicle cycle_Homo sapiens_hsa047211.99234720
12Homologous recombination_Homo sapiens_hsa034401.90526084
13Fanconi anemia pathway_Homo sapiens_hsa034601.86662064
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.83283466
15Ether lipid metabolism_Homo sapiens_hsa005651.77236517
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68011446
17Tryptophan metabolism_Homo sapiens_hsa003801.66787434
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66705492
19GABAergic synapse_Homo sapiens_hsa047271.65060429
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63555941
21Parkinsons disease_Homo sapiens_hsa050121.61615551
22Olfactory transduction_Homo sapiens_hsa047401.55151272
23Protein export_Homo sapiens_hsa030601.46282219
24One carbon pool by folate_Homo sapiens_hsa006701.39762651
25Sulfur relay system_Homo sapiens_hsa041221.37737064
26Basal transcription factors_Homo sapiens_hsa030221.36234660
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.30071171
28Huntingtons disease_Homo sapiens_hsa050161.28535042
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27790563
30Morphine addiction_Homo sapiens_hsa050321.25112169
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22146907
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21255038
33Proteasome_Homo sapiens_hsa030501.16840098
34Nicotine addiction_Homo sapiens_hsa050331.16203528
35Arachidonic acid metabolism_Homo sapiens_hsa005901.15627382
36Circadian rhythm_Homo sapiens_hsa047101.09975765
37Alzheimers disease_Homo sapiens_hsa050101.04316627
38Chemical carcinogenesis_Homo sapiens_hsa052041.04241602
39Circadian entrainment_Homo sapiens_hsa047131.03926045
40Peroxisome_Homo sapiens_hsa041461.01423697
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98603831
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95016343
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92121358
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89350605
45RNA degradation_Homo sapiens_hsa030180.88270413
46Dorso-ventral axis formation_Homo sapiens_hsa043200.87667808
47Dopaminergic synapse_Homo sapiens_hsa047280.85760302
48Glutamatergic synapse_Homo sapiens_hsa047240.85681963
49* Cholinergic synapse_Homo sapiens_hsa047250.81558558
50Fructose and mannose metabolism_Homo sapiens_hsa000510.79513922
51Cardiac muscle contraction_Homo sapiens_hsa042600.79502874
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78760659
53Ovarian steroidogenesis_Homo sapiens_hsa049130.78587070
54Insulin secretion_Homo sapiens_hsa049110.77083829
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.76677920
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76227257
57Fat digestion and absorption_Homo sapiens_hsa049750.75160385
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74820545
59Retinol metabolism_Homo sapiens_hsa008300.72820112
60Histidine metabolism_Homo sapiens_hsa003400.71639769
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.71510443
62Dilated cardiomyopathy_Homo sapiens_hsa054140.70862806
63Serotonergic synapse_Homo sapiens_hsa047260.70394091
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69845041
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69630329
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67360128
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66141987
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.66112036
69Metabolic pathways_Homo sapiens_hsa011000.65715668
70Nitrogen metabolism_Homo sapiens_hsa009100.64319906
71Pyrimidine metabolism_Homo sapiens_hsa002400.62690612
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61765774
73beta-Alanine metabolism_Homo sapiens_hsa004100.61641245
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61614235
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61607482
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61559756
77ABC transporters_Homo sapiens_hsa020100.61312422
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59896105
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58885631
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.58135525
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57877431
82Nucleotide excision repair_Homo sapiens_hsa034200.57840074
83Vitamin digestion and absorption_Homo sapiens_hsa049770.57799475
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.57672885
85Hedgehog signaling pathway_Homo sapiens_hsa043400.57516999
86Renin secretion_Homo sapiens_hsa049240.57197319
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57151988
88Regulation of autophagy_Homo sapiens_hsa041400.55274291
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52936974
90Biosynthesis of amino acids_Homo sapiens_hsa012300.52339093
91Fatty acid degradation_Homo sapiens_hsa000710.52171545
92Salivary secretion_Homo sapiens_hsa049700.51348789
93* Oxytocin signaling pathway_Homo sapiens_hsa049210.50589983
94Ribosome_Homo sapiens_hsa030100.49063218
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47574593
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46391396
97cAMP signaling pathway_Homo sapiens_hsa040240.46335569
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44235988
99Galactose metabolism_Homo sapiens_hsa000520.43696571
100Sulfur metabolism_Homo sapiens_hsa009200.43224787
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.42573609
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42569934
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42457960
104RNA transport_Homo sapiens_hsa030130.41905181
105Non-homologous end-joining_Homo sapiens_hsa034500.41437614
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40039026
107Primary immunodeficiency_Homo sapiens_hsa053400.38751249
108mTOR signaling pathway_Homo sapiens_hsa041500.38709026
109Purine metabolism_Homo sapiens_hsa002300.38240886
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37965778
111Basal cell carcinoma_Homo sapiens_hsa052170.37622365
112Type II diabetes mellitus_Homo sapiens_hsa049300.37615229
113HIF-1 signaling pathway_Homo sapiens_hsa040660.35403464
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34790994
115Calcium signaling pathway_Homo sapiens_hsa040200.34088915
116Carbon metabolism_Homo sapiens_hsa012000.33623283
117Inositol phosphate metabolism_Homo sapiens_hsa005620.33612421
118Glycerolipid metabolism_Homo sapiens_hsa005610.32457854
119Arginine biosynthesis_Homo sapiens_hsa002200.32363434
120Gastric acid secretion_Homo sapiens_hsa049710.31882067
121AMPK signaling pathway_Homo sapiens_hsa041520.31221261
122Glucagon signaling pathway_Homo sapiens_hsa049220.30935032
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.29985805
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27305743
125Cocaine addiction_Homo sapiens_hsa050300.26167762
126Fatty acid elongation_Homo sapiens_hsa000620.25842804
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23114053
128Caffeine metabolism_Homo sapiens_hsa002320.22750852
129Lysine degradation_Homo sapiens_hsa003100.22520828
130Collecting duct acid secretion_Homo sapiens_hsa049660.22125499
131Mineral absorption_Homo sapiens_hsa049780.22080343
132Pentose phosphate pathway_Homo sapiens_hsa000300.21738136
133Long-term potentiation_Homo sapiens_hsa047200.21650191
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.21446274
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20274688
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18696235
137Fatty acid metabolism_Homo sapiens_hsa012120.17959511
138Amphetamine addiction_Homo sapiens_hsa050310.17637793
139Pyruvate metabolism_Homo sapiens_hsa006200.17425962
140GnRH signaling pathway_Homo sapiens_hsa049120.16583873
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16420812
142Bile secretion_Homo sapiens_hsa049760.14799941
143MAPK signaling pathway_Homo sapiens_hsa040100.14217232
144Alcoholism_Homo sapiens_hsa050340.14140681
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.14091135
146Renal cell carcinoma_Homo sapiens_hsa052110.13943704
147Pancreatic secretion_Homo sapiens_hsa049720.13690989
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13642116
149Fatty acid biosynthesis_Homo sapiens_hsa000610.12917121
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12403654
151Taste transduction_Homo sapiens_hsa047420.12227204
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11613487
153Ras signaling pathway_Homo sapiens_hsa040140.11267554
154Insulin resistance_Homo sapiens_hsa049310.11149447
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.11034818
156Gap junction_Homo sapiens_hsa045400.10946486
157Insulin signaling pathway_Homo sapiens_hsa049100.10705501
158Chemokine signaling pathway_Homo sapiens_hsa040620.10367384
159Choline metabolism in cancer_Homo sapiens_hsa052310.08128765
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07864997
161Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07510265
162Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06806258
163Propanoate metabolism_Homo sapiens_hsa006400.05352246
164ErbB signaling pathway_Homo sapiens_hsa040120.04464611
165Hippo signaling pathway_Homo sapiens_hsa043900.04247523

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »