KCNJ15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)9.63947506
2drug transmembrane transport (GO:0006855)9.50673653
3drug transport (GO:0015893)7.94859086
4organic cation transport (GO:0015695)7.89198592
5phosphate ion transport (GO:0006817)7.66696401
6lysine catabolic process (GO:0006554)6.99383670
7lysine metabolic process (GO:0006553)6.99383670
8phosphate ion transmembrane transport (GO:0035435)6.42412122
9quaternary ammonium group transport (GO:0015697)6.28749100
10exogenous drug catabolic process (GO:0042738)6.09878228
11drug catabolic process (GO:0042737)6.03107471
12cysteine metabolic process (GO:0006534)5.82784058
13renal absorption (GO:0070293)5.78232066
14excretion (GO:0007588)5.76379318
15glyoxylate metabolic process (GO:0046487)5.67527528
16phosphate ion homeostasis (GO:0055062)5.56485199
17trivalent inorganic anion homeostasis (GO:0072506)5.56485199
18nonribosomal peptide biosynthetic process (GO:0019184)5.44245118
19response to mercury ion (GO:0046689)5.39495072
20vitamin D metabolic process (GO:0042359)5.24633985
21tricarboxylic acid metabolic process (GO:0072350)5.22450187
22toxin transport (GO:1901998)5.20242509
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15251804
24negative regulation of cell killing (GO:0031342)5.15251804
25metanephric tubule development (GO:0072170)5.08420022
26metanephric nephron tubule development (GO:0072234)5.08420022
27surfactant homeostasis (GO:0043129)5.03184540
28glutathione biosynthetic process (GO:0006750)4.92540764
29branched-chain amino acid metabolic process (GO:0009081)4.86658492
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79236332
31metanephric nephron epithelium development (GO:0072243)4.71680807
32short-chain fatty acid metabolic process (GO:0046459)4.69381349
33positive regulation by symbiont of host defense response (GO:0052509)4.69333432
34modulation by symbiont of host defense response (GO:0052031)4.69333432
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.69333432
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.69333432
37positive regulation by organism of defense response of other organism involved in symbiotic interact4.69333432
38modulation by symbiont of host immune response (GO:0052553)4.69333432
39sodium-independent organic anion transport (GO:0043252)4.65460142
40valine metabolic process (GO:0006573)4.63880483
41amino-acid betaine transport (GO:0015838)4.55188208
42carnitine transport (GO:0015879)4.55188208
43glycoside metabolic process (GO:0016137)4.52236851
44aspartate family amino acid catabolic process (GO:0009068)4.44326558
45peptide catabolic process (GO:0043171)4.41974844
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.40502054
47activated T cell proliferation (GO:0050798)4.37142501
48microglial cell activation (GO:0001774)4.34822587
49metanephric epithelium development (GO:0072207)4.32490486
50nephron tubule development (GO:0072080)4.27970800
51regulation of B cell receptor signaling pathway (GO:0050855)4.18017464
52homocysteine metabolic process (GO:0050667)4.15677152
53modified amino acid transport (GO:0072337)4.11523566
54cellular response to interleukin-15 (GO:0071350)4.09281776
55positive regulation of gamma-delta T cell activation (GO:0046645)4.08646354
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06786151
57detection of molecule of bacterial origin (GO:0032490)4.04337515
58proline metabolic process (GO:0006560)4.00458748
59chemical homeostasis within a tissue (GO:0048875)3.98058276
60peptide biosynthetic process (GO:0043043)3.93882265
61branched-chain amino acid catabolic process (GO:0009083)3.93308486
62fatty acid beta-oxidation (GO:0006635)3.91990839
63response to interleukin-15 (GO:0070672)3.90608622
64macrophage activation involved in immune response (GO:0002281)3.85687031
65renal tubule development (GO:0061326)3.84989015
66cellular modified amino acid catabolic process (GO:0042219)3.84945487
67indolalkylamine catabolic process (GO:0046218)3.84794383
68tryptophan catabolic process (GO:0006569)3.84794383
69indole-containing compound catabolic process (GO:0042436)3.84794383
70amino-acid betaine metabolic process (GO:0006577)3.79270571
71aromatic amino acid family catabolic process (GO:0009074)3.78685950
72cellular extravasation (GO:0045123)3.76691170
73negative regulation of lymphocyte mediated immunity (GO:0002707)3.74632808
74response to parathyroid hormone (GO:0071107)3.73525132
75leukocyte migration involved in inflammatory response (GO:0002523)3.70717581
76L-phenylalanine metabolic process (GO:0006558)3.68994461
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.68994461
78antigen processing and presentation of endogenous antigen (GO:0019883)3.68519094
79interferon-gamma secretion (GO:0072643)3.65757941
80regulation of interferon-beta biosynthetic process (GO:0045357)3.64373314
81L-phenylalanine catabolic process (GO:0006559)3.63645128
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.63645128
83fatty acid oxidation (GO:0019395)3.62779807
842-oxoglutarate metabolic process (GO:0006103)3.61712257
85nephron epithelium morphogenesis (GO:0072088)3.61612173
86nephron tubule morphogenesis (GO:0072078)3.61612173
87tryptophan metabolic process (GO:0006568)3.60916462
88cellular response to vitamin D (GO:0071305)3.60574851
89serine family amino acid catabolic process (GO:0009071)3.59168175
90neutrophil activation (GO:0042119)3.58198067
91behavioral response to nicotine (GO:0035095)3.57930761
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57419881
93polyol transport (GO:0015791)3.56063009
94lipid oxidation (GO:0034440)3.55717774
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55576626
96serine family amino acid metabolic process (GO:0009069)3.55047622
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.54534113
98carnitine metabolic process (GO:0009437)3.54530431
99nephron epithelium development (GO:0072009)3.53796533
100fructose metabolic process (GO:0006000)3.52784714
101glutathione metabolic process (GO:0006749)3.52262808
102glutathione derivative metabolic process (GO:1901685)3.51847807
103glutathione derivative biosynthetic process (GO:1901687)3.51847807
104regulation of gamma-delta T cell activation (GO:0046643)3.51192831
105response to phenylpropanoid (GO:0080184)3.50164857
106negative regulation of interleukin-1 production (GO:0032692)3.49662863
107oligosaccharide catabolic process (GO:0009313)3.46399363
108acetyl-CoA metabolic process (GO:0006084)3.45378367
109sulfur compound transport (GO:0072348)3.43753701
110neutrophil activation involved in immune response (GO:0002283)3.43426087
111tolerance induction (GO:0002507)3.43388542
112detection of other organism (GO:0098543)3.40291720
113neutrophil mediated immunity (GO:0002446)3.39780237
114response to growth hormone (GO:0060416)3.39660279
115detection of external biotic stimulus (GO:0098581)3.38509313
116negative regulation of T cell mediated immunity (GO:0002710)3.36150808
117vitamin transport (GO:0051180)3.34553032
118sulfate transmembrane transport (GO:1902358)3.33651468
119cellular response to vitamin (GO:0071295)3.32316415
120L-ascorbic acid metabolic process (GO:0019852)3.29600572
121glucuronate metabolic process (GO:0019585)3.27128639
122uronic acid metabolic process (GO:0006063)3.27128639
123negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26289665
124negative regulation of interleukin-12 production (GO:0032695)3.25832534
125negative regulation of interleukin-1 beta production (GO:0032691)3.25139373
126response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23959828
127response to host immune response (GO:0052572)3.23959828
128regulation of gamma-delta T cell differentiation (GO:0045586)3.23068188
129thyroid hormone metabolic process (GO:0042403)3.20993082
130macrophage activation (GO:0042116)3.20013841
131positive regulation of mast cell activation (GO:0033005)3.19151602
132DNA deamination (GO:0045006)3.18383502
133fatty acid catabolic process (GO:0009062)3.15948015
134positive regulation of T cell mediated cytotoxicity (GO:0001916)3.15278077
135cellular ketone body metabolic process (GO:0046950)3.14546939
136regulation of T cell mediated cytotoxicity (GO:0001914)3.13770188
137response to magnesium ion (GO:0032026)3.13680800
138regulation of germinal center formation (GO:0002634)3.10986487
139thyroid hormone generation (GO:0006590)3.10773640
140biotin metabolic process (GO:0006768)3.10704322
141response to thyroid hormone (GO:0097066)3.10133028
142cobalamin metabolic process (GO:0009235)3.10056638
143renal tubule morphogenesis (GO:0061333)3.08517416
144leukocyte aggregation (GO:0070486)3.07580699
145sulfur amino acid catabolic process (GO:0000098)3.07159006
146sodium ion transport (GO:0006814)3.07103294
147regulation of mast cell activation (GO:0033003)3.05837657
148glutamate metabolic process (GO:0006536)3.05127242
149detection of bacterium (GO:0016045)3.05039745
150cellular amino acid catabolic process (GO:0009063)3.03379625
151regulation of memory T cell differentiation (GO:0043380)3.02727212
152membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.02193542
153regulation of regulatory T cell differentiation (GO:0045589)3.01194084
154dendritic cell migration (GO:0036336)3.00210671
155myeloid leukocyte mediated immunity (GO:0002444)2.98732209
156granulocyte activation (GO:0036230)2.97916789
157regulation of apoptotic process involved in morphogenesis (GO:1902337)2.97505484
158indole-containing compound metabolic process (GO:0042430)2.97361284
159NADH metabolic process (GO:0006734)2.95891307
160detection of biotic stimulus (GO:0009595)2.94954510
161negative regulation of T-helper cell differentiation (GO:0045623)2.94446591
162negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94446591
163myeloid cell activation involved in immune response (GO:0002275)2.93318269
164negative regulation of leukocyte mediated immunity (GO:0002704)2.92446687
165negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.92222431
166positive regulation of interferon-alpha production (GO:0032727)2.91945684
167respiratory burst (GO:0045730)2.91115458
168sulfation (GO:0051923)2.91015010
169regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87819909
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83377513
171production of molecular mediator involved in inflammatory response (GO:0002532)2.82701554
172regulation of interleukin-6 biosynthetic process (GO:0045408)2.80375751
173negative regulation of B cell mediated immunity (GO:0002713)2.79567597
174negative regulation of immunoglobulin mediated immune response (GO:0002890)2.79567597
175mast cell activation (GO:0045576)2.78820127
176regulation of interferon-alpha production (GO:0032647)2.76513893
177response to host defenses (GO:0052200)2.74984721
178response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.74984721
179response to host (GO:0075136)2.74984721
180dendritic cell chemotaxis (GO:0002407)2.74871748
181superoxide anion generation (GO:0042554)2.74095662
182leukocyte degranulation (GO:0043299)2.73095930
183positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70987661
184cellular response to exogenous dsRNA (GO:0071360)2.65582235
185positive regulation of defense response to virus by host (GO:0002230)2.64548808
186negative regulation of adaptive immune response (GO:0002820)2.64062623
187response to interferon-beta (GO:0035456)2.63423275
188regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62087376
189positive regulation of mast cell degranulation (GO:0043306)2.60976220
190positive regulation of mast cell activation involved in immune response (GO:0033008)2.60976220
191response to type I interferon (GO:0034340)2.60657601
192negative regulation of interleukin-6 production (GO:0032715)2.60486343
193membrane repolarization during action potential (GO:0086011)2.59790423
194positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.59303825
195T cell mediated immunity (GO:0002456)2.58211562
196cytidine deamination (GO:0009972)2.58200512
197cytidine metabolic process (GO:0046087)2.58200512
198cytidine catabolic process (GO:0006216)2.58200512
199response to peptidoglycan (GO:0032494)2.56188526
200aminoglycoside antibiotic metabolic process (GO:0030647)10.3371890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.19042922
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.53749751
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.46344865
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.28175588
5EZH2_22144423_ChIP-Seq_EOC_Human3.24695632
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.19869348
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.11077116
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10035169
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.94516443
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62783276
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59924827
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.54195080
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.53604613
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.44085214
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42663834
16ZNF274_21170338_ChIP-Seq_K562_Hela2.33638145
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33352111
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.28164727
19RUNX_20019798_ChIP-Seq_JUKART_Human2.27366898
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.13342834
21CDX2_20551321_ChIP-Seq_CACO-2_Human2.10078928
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90994451
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86544847
24CLOCK_20551151_ChIP-Seq_293T_Human1.86198921
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80416066
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80030898
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76215277
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.73615366
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69817006
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68631903
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66466676
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66203128
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65761733
34ER_23166858_ChIP-Seq_MCF-7_Human1.64056742
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59847004
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.57351535
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.56075204
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.54749759
39GATA4_25053715_ChIP-Seq_YYC3_Human1.52003739
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51219785
41GATA3_26560356_Chip-Seq_TH2_Human1.49140677
42AHR_22903824_ChIP-Seq_MCF-7_Human1.49067005
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47966393
44* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45691081
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45512102
46SOX2_20726797_ChIP-Seq_SW620_Human1.44446908
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.44358815
48* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43553730
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43313868
50* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42843406
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.42287284
52VDR_22108803_ChIP-Seq_LS180_Human1.42042061
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41289763
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40902472
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.40837573
56TAF15_26573619_Chip-Seq_HEK293_Human1.39362794
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.38041809
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37924337
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35561840
60* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35441508
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.34891384
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34347362
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33581300
64P300_19829295_ChIP-Seq_ESCs_Human1.32834588
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.31554840
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31088630
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29059230
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.28104448
69DROSHA_22980978_ChIP-Seq_HELA_Human1.27347034
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26653197
71* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25792458
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25684834
73GATA3_27048872_Chip-Seq_THYMUS_Human1.25555032
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25471993
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25471993
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25143839
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24721542
78MYB_26560356_Chip-Seq_TH2_Human1.23594400
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23283302
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23194999
81SCL_19346495_ChIP-Seq_HPC-7_Human1.22764104
82GBX2_23144817_ChIP-Seq_PC3_Human1.22762178
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22261748
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21756685
85* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20884627
86GATA1_22025678_ChIP-Seq_K562_Human1.19887911
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.19664043
88EGR1_19032775_ChIP-ChIP_M12_Human1.19586283
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19486743
90TP53_16413492_ChIP-PET_HCT116_Human1.18806283
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18114908
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18114908
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17185660
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.17091093
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16771798
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16657102
97AR_21909140_ChIP-Seq_LNCAP_Human1.14952818
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13857768
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13842934
100* RXR_22108803_ChIP-Seq_LS180_Human1.13001252
101* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11801344
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.11742637
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.11742637
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11516544
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11346419
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11346419
107* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11037606
108* CJUN_26792858_Chip-Seq_BT549_Human1.11015355
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10409508
110STAT3_23295773_ChIP-Seq_U87_Human1.10372381
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10338119
112TP53_18474530_ChIP-ChIP_U2OS_Human1.08223623
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07520546
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.06808839
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05786646
116* SMRT_27268052_Chip-Seq_Bcells_Human1.05527966
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04800255
118IRF1_19129219_ChIP-ChIP_H3396_Human1.04628725
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04042861
120* GATA3_21878914_ChIP-Seq_MCF-7_Human1.03533305
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.03384549
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03384549
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03141750
124GATA2_21666600_ChIP-Seq_HMVEC_Human1.03133133
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02845510
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02231581
127JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02142383
128* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02130476
129EWS_26573619_Chip-Seq_HEK293_Human1.01770898
130SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01437834
131HNF4A_19822575_ChIP-Seq_HepG2_Human1.01341022
132* REST_21632747_ChIP-Seq_MESCs_Mouse1.01134325
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00357355
134EED_16625203_ChIP-ChIP_MESCs_Mouse1.00322664
135NFE2_27457419_Chip-Seq_LIVER_Mouse1.00274095
136AR_25329375_ChIP-Seq_VCAP_Human1.00273809
137VDR_24787735_ChIP-Seq_THP-1_Human1.00088154
138RACK7_27058665_Chip-Seq_MCF-7_Human0.99962244
139CDX2_22108803_ChIP-Seq_LS180_Human0.99541727
140RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99333084
141TCF4_23295773_ChIP-Seq_U87_Human0.98851596
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98790261
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98477945
144SMAD4_21799915_ChIP-Seq_A2780_Human0.98457106
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98352143
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98128591
147* TP63_23658742_ChIP-Seq_EP156T_Human0.96569470
148RUNX2_22187159_ChIP-Seq_PCA_Human0.96542075
149AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96429819
150* OCT1_27270436_Chip-Seq_PROSTATE_Human0.96327184
151IGF1R_20145208_ChIP-Seq_DFB_Human0.95930694
152SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95898256
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95560144
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.95235278
155* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94903459
156AR_21572438_ChIP-Seq_LNCaP_Human0.94894961
157ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94799354
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94637770
159TP53_22573176_ChIP-Seq_HFKS_Human0.94607396
160SPI1_23127762_ChIP-Seq_K562_Human0.92499046
161RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92381303
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92220300
163SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92203130
164GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91937485
165TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91511830
166EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90576125
167GATA6_25053715_ChIP-Seq_YYC3_Human0.90034072
168SPI1_23547873_ChIP-Seq_NB4_Human0.89835603
169SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89814119
170TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89695594
171GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89672625
172FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89421599
173WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88683682
174JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88656487
175OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88163456
176BCAT_22108803_ChIP-Seq_LS180_Human0.88111308
177* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87412627
178AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85924190
179TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85839053
180SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85697251
181WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81723272
182NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81158496
183PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81046998
184* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80642924
185TCF4_22108803_ChIP-Seq_LS180_Human0.79968711
186ERG_21242973_ChIP-ChIP_JURKAT_Human0.77923452
187LXR_22292898_ChIP-Seq_THP-1_Human0.77532137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.51235917
2MP0004043_abnormal_pH_regulation5.97771420
3MP0004019_abnormal_vitamin_homeostasis4.83706694
4MP0005332_abnormal_amino_acid4.45286809
5MP0002138_abnormal_hepatobiliary_system4.41250274
6MP0002139_abnormal_hepatobiliary_system3.85875883
7MP0001958_emphysema3.81131057
8MP0009643_abnormal_urine_homeostasis3.75804806
9MP0000569_abnormal_digit_pigmentation3.75197205
10MP0001765_abnormal_ion_homeostasis3.66020194
11MP0003195_calcinosis3.45979683
12MP0003878_abnormal_ear_physiology3.16803515
13MP0005377_hearing/vestibular/ear_phenot3.16803515
14MP0003436_decreased_susceptibility_to3.00794114
15MP0005671_abnormal_response_to2.99418358
16MP0001756_abnormal_urination2.94144073
17MP0002136_abnormal_kidney_physiology2.93749963
18MP0005636_abnormal_mineral_homeostasis2.86613619
19MP0001835_abnormal_antigen_presentation2.66677716
20MP0008875_abnormal_xenobiotic_pharmacok2.60180264
21MP0000685_abnormal_immune_system2.52339304
22MP0001800_abnormal_humoral_immune2.51469214
23MP0002277_abnormal_respiratory_mucosa2.50348864
24MP0009785_altered_susceptibility_to2.43886490
25MP0002419_abnormal_innate_immunity2.32616683
26MP0008877_abnormal_DNA_methylation2.22316184
27MP0005387_immune_system_phenotype2.19170656
28MP0001790_abnormal_immune_system2.19170656
29MP0002723_abnormal_immune_serum2.16739467
30MP0005000_abnormal_immune_tolerance2.11795621
31MP0005025_abnormal_response_to2.10301579
32MP0003252_abnormal_bile_duct2.10279313
33MP0002876_abnormal_thyroid_physiology2.01788141
34MP0002452_abnormal_antigen_presenting2.01192716
35MP0002420_abnormal_adaptive_immunity1.96149818
36MP0001819_abnormal_immune_cell1.95835816
37MP0005058_abnormal_lysosome_morphology1.92757775
38MP0000538_abnormal_urinary_bladder1.89276473
39MP0002148_abnormal_hypersensitivity_rea1.88628412
40MP0008004_abnormal_stomach_pH1.80018384
41MP0005365_abnormal_bile_salt1.79160009
42MP0001533_abnormal_skeleton_physiology1.75421803
43MP0003186_abnormal_redox_activity1.74087190
44MP0004782_abnormal_surfactant_physiolog1.72972811
45MP0005085_abnormal_gallbladder_physiolo1.72216435
46MP0002653_abnormal_ependyma_morphology1.70536512
47MP0004130_abnormal_muscle_cell1.64453609
48MP0003303_peritoneal_inflammation1.59689738
49MP0002405_respiratory_system_inflammati1.57598561
50MP0001501_abnormal_sleep_pattern1.52778479
51MP0002168_other_aberrant_phenotype1.51239001
52MP0004885_abnormal_endolymph1.49369589
53MP0008961_abnormal_basal_metabolism1.45592529
54MP0003300_gastrointestinal_ulcer1.44516559
55MP0000716_abnormal_immune_system1.39372124
56MP0005084_abnormal_gallbladder_morpholo1.37690344
57MP0003787_abnormal_imprinting1.36282923
58MP0002928_abnormal_bile_duct1.36017582
59MP0005174_abnormal_tail_pigmentation1.34722373
60MP0000465_gastrointestinal_hemorrhage1.34117823
61MP0001845_abnormal_inflammatory_respons1.32370151
62MP0005670_abnormal_white_adipose1.32164002
63MP0003646_muscle_fatigue1.31618031
64MP0005584_abnormal_enzyme/coenzyme_acti1.30496836
65MP0003866_abnormal_defecation1.29841852
66MP0004381_abnormal_hair_follicle1.28333227
67MP0006082_CNS_inflammation1.27851794
68MP0004883_abnormal_blood_vessel1.26270547
69MP0002254_reproductive_system_inflammat1.24945826
70MP0001986_abnormal_taste_sensitivity1.24780130
71MP0004142_abnormal_muscle_tone1.21305328
72MP0001968_abnormal_touch/_nociception1.16610091
73MP0002398_abnormal_bone_marrow1.14583265
74MP0002102_abnormal_ear_morphology1.14487401
75MP0000689_abnormal_spleen_morphology1.14108512
76MP0002896_abnormal_bone_mineralization1.13461662
77MP0005319_abnormal_enzyme/_coenzyme1.12947417
78MP0000678_abnormal_parathyroid_gland1.12214837
79MP0002135_abnormal_kidney_morphology1.10276797
80MP0008872_abnormal_physiological_respon1.09472397
81MP0003191_abnormal_cellular_cholesterol1.09462687
82MP0003724_increased_susceptibility_to1.09034601
83MP0004272_abnormal_basement_membrane1.08840709
84MP0009745_abnormal_behavioral_response1.08355416
85MP0000230_abnormal_systemic_arterial1.06811588
86MP0003763_abnormal_thymus_physiology1.06786543
87MP0001440_abnormal_grooming_behavior1.06091511
88MP0005551_abnormal_eye_electrophysiolog1.03809521
89MP0005666_abnormal_adipose_tissue1.03739197
90MP0002796_impaired_skin_barrier1.03684658
91MP0001177_atelectasis1.02375253
92MP0010234_abnormal_vibrissa_follicle1.02052169
93MP0005164_abnormal_response_to1.01987598
94MP0003011_delayed_dark_adaptation0.99087681
95MP0002722_abnormal_immune_system0.99017517
96MP0005075_abnormal_melanosome_morpholog0.97693886
97MP0008469_abnormal_protein_level0.97524308
98MP0004264_abnormal_extraembryonic_tissu0.97031795
99MP0005451_abnormal_body_composition0.96596942
100MP0002429_abnormal_blood_cell0.94467758
101MP0002098_abnormal_vibrissa_morphology0.93260615
102MP0000427_abnormal_hair_cycle0.92610865
103MP0001666_abnormal_nutrient_absorption0.91448652
104MP0001486_abnormal_startle_reflex0.91438038
105MP0003183_abnormal_peptide_metabolism0.89552308
106MP0010155_abnormal_intestine_physiology0.88797806
107MP0004147_increased_porphyrin_level0.87381663
108MP0003828_pulmonary_edema0.86810431
109MP0005535_abnormal_body_temperature0.85600814
110MP0002272_abnormal_nervous_system0.85556294
111MP0003638_abnormal_response/metabolism_0.85549685
112MP0001919_abnormal_reproductive_system0.85494906
113MP0005464_abnormal_platelet_physiology0.85015067
114MP0000470_abnormal_stomach_morphology0.81014003
115MP0005389_reproductive_system_phenotype0.80991834
116MP0003045_fibrosis0.80712665
117MP0000383_abnormal_hair_follicle0.80620166
118MP0009764_decreased_sensitivity_to0.80451818
119MP0002118_abnormal_lipid_homeostasis0.80115322
120MP0002295_abnormal_pulmonary_circulatio0.79630406
121MP0002133_abnormal_respiratory_system0.76568833
122MP0005388_respiratory_system_phenotype0.76568833
123MP0000703_abnormal_thymus_morphology0.75966835
124MP0000631_abnormal_neuroendocrine_gland0.75577919
125MP0002132_abnormal_respiratory_system0.73934209
126MP0004947_skin_inflammation0.73887206
127MP0002693_abnormal_pancreas_physiology0.72951123
128MP0005167_abnormal_blood-brain_barrier0.72643793
129MP0002064_seizures0.71508362
130MP0002089_abnormal_postnatal_growth/wei0.70270366
131MP0002735_abnormal_chemical_nociception0.70232756
132MP0005395_other_phenotype0.69698635
133MP0001485_abnormal_pinna_reflex0.68791617
134MP0005390_skeleton_phenotype0.68231523
135MP0003879_abnormal_hair_cell0.67752596
136MP0001664_abnormal_digestion0.67699978
137MP0003283_abnormal_digestive_organ0.66775515
138MP0002733_abnormal_thermal_nociception0.66641759
139MP0005165_increased_susceptibility_to0.66525293
140MP0002998_abnormal_bone_remodeling0.66408070
141MP0002166_altered_tumor_susceptibility0.66195803
142MP0010386_abnormal_urinary_bladder0.66132707
143MP0002115_abnormal_skeleton_extremities0.65134297
144MP0001873_stomach_inflammation0.64590165
145MP0005501_abnormal_skin_physiology0.64058963
146MP0002332_abnormal_exercise_endurance0.63342246
147MP0000681_abnormal_thyroid_gland0.62501988
148MP0006036_abnormal_mitochondrial_physio0.62458400
149MP0001661_extended_life_span0.62117275
150MP0001346_abnormal_lacrimal_gland0.61642282
151MP0009642_abnormal_blood_homeostasis0.60315726
152MP0001764_abnormal_homeostasis0.60038732
153MP0000163_abnormal_cartilage_morphology0.59489829
154MP0005408_hypopigmentation0.58800927
155MP0003795_abnormal_bone_structure0.58040411
156MP0000534_abnormal_ureter_morphology0.57529589
157MP0004742_abnormal_vestibular_system0.55877099
158MP0003806_abnormal_nucleotide_metabolis0.55716895
159MP0005220_abnormal_exocrine_pancreas0.54933174
160MP0009780_abnormal_chondrocyte_physiolo0.53952342
161MP0004484_altered_response_of0.53536377
162MP0000762_abnormal_tongue_morphology0.53470507
163MP0000371_diluted_coat_color0.53436308
164MP0005275_abnormal_skin_tensile0.53221569
165MP0004858_abnormal_nervous_system0.50301591
166MP0003172_abnormal_lysosome_physiology0.50000664
167MP0001663_abnormal_digestive_system0.45990616
168MP0005375_adipose_tissue_phenotype0.45836982
169MP0010329_abnormal_lipoprotein_level0.45733748
170MP0003566_abnormal_cell_adhesion0.45158708
171MP0005310_abnormal_salivary_gland0.45127069
172MP0003959_abnormal_lean_body0.44857058
173MP0005083_abnormal_biliary_tract0.42009174
174MP0003075_altered_response_to0.41280745
175MP0008438_abnormal_cutaneous_collagen0.41180248
176MP0000609_abnormal_liver_physiology0.38341383
177MP0003953_abnormal_hormone_level0.37776853
178MP0002113_abnormal_skeleton_development0.37759310

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.57993277
2Hyperactive renin-angiotensin system (HP:0000841)7.41537119
3Hypokalemic alkalosis (HP:0001949)7.15822322
4Metabolic alkalosis (HP:0200114)7.05387076
5Gout (HP:0001997)7.01515230
6Hypomagnesemia (HP:0002917)6.85043881
7Abnormality of chloride homeostasis (HP:0011422)6.54506981
8Polyuria (HP:0000103)6.35982173
9Abnormality of renal excretion (HP:0011036)6.01620204
10Abnormal urine output (HP:0012590)5.98563070
11Abnormality of magnesium homeostasis (HP:0004921)5.73656868
12Tetany (HP:0001281)5.26670738
13Proximal tubulopathy (HP:0000114)5.24315592
14Abnormal drinking behavior (HP:0030082)5.11623998
15Polydipsia (HP:0001959)5.11623998
16Renal salt wasting (HP:0000127)5.11265985
17Abnormality of renin-angiotensin system (HP:0000847)5.02225274
18Increased purine levels (HP:0004368)5.01284529
19Hyperuricemia (HP:0002149)5.01284529
20Hyperaldosteronism (HP:0000859)4.86698017
21Myositis (HP:0100614)4.67255656
22Retrobulbar optic neuritis (HP:0100654)4.66156777
23Optic neuritis (HP:0100653)4.66156777
24Orchitis (HP:0100796)4.55444287
25Alkalosis (HP:0001948)4.51379992
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.43411186
27Abnormality of purine metabolism (HP:0004352)4.43271693
28Hyperglycinuria (HP:0003108)4.33515475
29Stomatitis (HP:0010280)4.21452363
30Hypercalciuria (HP:0002150)3.97063908
31Elevated erythrocyte sedimentation rate (HP:0003565)3.86351054
32Generalized aminoaciduria (HP:0002909)3.75514667
33Eczematoid dermatitis (HP:0000976)3.71673011
34Renal tubular acidosis (HP:0001947)3.67491901
35Recurrent bacterial skin infections (HP:0005406)3.66288178
36Hypokalemia (HP:0002900)3.66057258
37Recurrent abscess formation (HP:0002722)3.51975899
38Abnormality of glycine metabolism (HP:0010895)3.50227472
39Abnormality of serine family amino acid metabolism (HP:0010894)3.50227472
40Glycosuria (HP:0003076)3.48187104
41Abnormality of urine glucose concentration (HP:0011016)3.48187104
42Keratoconjunctivitis (HP:0001096)3.44560612
43Keratoconjunctivitis sicca (HP:0001097)3.37860541
44Pancreatic cysts (HP:0001737)3.37170245
45Ketoacidosis (HP:0001993)3.34757634
46Abnormality of potassium homeostasis (HP:0011042)3.27789653
47Abnormality of proline metabolism (HP:0010907)3.19488268
48Hydroxyprolinuria (HP:0003080)3.19488268
49Recurrent fungal infections (HP:0002841)3.12675849
50Encephalitis (HP:0002383)3.12270144
51Hypochromic microcytic anemia (HP:0004840)3.11828935
52Abnormal delayed hypersensitivity skin test (HP:0002963)3.11344946
53Abnormality of nucleobase metabolism (HP:0010932)3.11178289
54Stomach cancer (HP:0012126)3.01132491
55Hyperphosphaturia (HP:0003109)2.96603925
56Nephrocalcinosis (HP:0000121)2.95261271
57Congenital stationary night blindness (HP:0007642)2.92841903
58Abnormal urine phosphate concentration (HP:0012599)2.91894890
59Delayed epiphyseal ossification (HP:0002663)2.90196283
60Vascular calcification (HP:0004934)2.86318943
61Gastrointestinal infarctions (HP:0005244)2.85691172
62Thyroid-stimulating hormone excess (HP:0002925)2.84301169
63Tubulointerstitial fibrosis (HP:0005576)2.83160660
64Clumsiness (HP:0002312)2.82229347
65Ketosis (HP:0001946)2.81563503
66Congenital, generalized hypertrichosis (HP:0004540)2.80666660
67Pancreatic fibrosis (HP:0100732)2.79927753
68Congenital sensorineural hearing impairment (HP:0008527)2.77968725
69Genetic anticipation (HP:0003743)2.77299933
70Chronic mucocutaneous candidiasis (HP:0002728)2.73916405
71Recurrent cutaneous fungal infections (HP:0011370)2.73916405
72Abnormality of T cell number (HP:0011839)2.72578476
73Nephrolithiasis (HP:0000787)2.72199206
74Recurrent gram-negative bacterial infections (HP:0005420)2.71851958
75Dehydration (HP:0001944)2.71130844
76Mediastinal lymphadenopathy (HP:0100721)2.70946256
77True hermaphroditism (HP:0010459)2.68486668
78Cardiovascular calcification (HP:0011915)2.67663147
79Hyperventilation (HP:0002883)2.65886536
80T lymphocytopenia (HP:0005403)2.63616845
81Abnormality of macrophages (HP:0004311)2.60101470
82Goiter (HP:0000853)2.57571156
83Abnormality of midbrain morphology (HP:0002418)2.55782530
84Molar tooth sign on MRI (HP:0002419)2.55782530
85Hypophosphatemia (HP:0002148)2.55467271
86Hypochromic anemia (HP:0001931)2.55366082
87Recurrent skin infections (HP:0001581)2.55124740
88Rickets (HP:0002748)2.52785103
89Widely patent fontanelles and sutures (HP:0004492)2.51666774
90Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51529495
91Absent/shortened dynein arms (HP:0200106)2.50140387
92Dynein arm defect of respiratory motile cilia (HP:0012255)2.50140387
93Vacuolated lymphocytes (HP:0001922)2.49073158
94Delayed CNS myelination (HP:0002188)2.48983019
95Progressive cerebellar ataxia (HP:0002073)2.47236923
96Tubular atrophy (HP:0000092)2.44654768
97Abolished electroretinogram (ERG) (HP:0000550)2.43908714
98Hemoptysis (HP:0002105)2.42761371
99Abnormality of fatty-acid metabolism (HP:0004359)2.41885496
100Nephronophthisis (HP:0000090)2.37931281
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37573363
102Pulmonary infiltrates (HP:0002113)2.35987426
103Hyperglycinemia (HP:0002154)2.33980859
104Vasculitis (HP:0002633)2.33529581
105Ventricular fibrillation (HP:0001663)2.33228649
106Inability to walk (HP:0002540)2.31890626
107Anorexia (HP:0002039)2.31780018
108Hyponatremia (HP:0002902)2.31397206
109Meningitis (HP:0001287)2.30716610
110Abnormality of sodium homeostasis (HP:0010931)2.29826531
111Adrenal overactivity (HP:0002717)2.29627075
112Abnormality of the renal medulla (HP:0100957)2.29587163
113Episodic fever (HP:0001954)2.29290643
114Abnormality of T cells (HP:0002843)2.29144534
115Progressive inability to walk (HP:0002505)2.28494998
116Bilateral sensorineural hearing impairment (HP:0008619)2.28043884
117Attenuation of retinal blood vessels (HP:0007843)2.27602419
118Abnormality of renal resorption (HP:0011038)2.27534466
119Renal tubular dysfunction (HP:0000124)2.24501430
120Enlarged kidneys (HP:0000105)2.24481194
121Tachypnea (HP:0002789)2.23984300
122Metaphyseal cupping (HP:0003021)2.23380783
123Furrowed tongue (HP:0000221)2.22166108
124Leukocytosis (HP:0001974)2.19271424
125IgG deficiency (HP:0004315)2.16024725
126Potter facies (HP:0002009)2.15987822
127Facial shape deformation (HP:0011334)2.15987822
128Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15760153
129Thin bony cortex (HP:0002753)2.14564867
130Decreased central vision (HP:0007663)2.12360648
131Hemiplegia (HP:0002301)2.12054633
132Hyperkalemia (HP:0002153)2.11661329
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08253141
134Abnormal rod and cone electroretinograms (HP:0008323)2.07944038
135Large for gestational age (HP:0001520)2.07832799
136Malnutrition (HP:0004395)2.06918870
137Abnormal enzyme/coenzyme activity (HP:0012379)2.06433831
138Metabolic acidosis (HP:0001942)2.05842987
139Vomiting (HP:0002013)2.02346722
140Confusion (HP:0001289)2.01050968
141Abnormality of alkaline phosphatase activity (HP:0004379)1.99715001
142Dicarboxylic aciduria (HP:0003215)1.99417973
143Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99417973
144Chronic obstructive pulmonary disease (HP:0006510)1.99059318
145Obstructive lung disease (HP:0006536)1.99059318
146Agitation (HP:0000713)1.99022233
147Abnormality of T cell physiology (HP:0011840)1.96567250
148Chronic otitis media (HP:0000389)1.95645864
149Tubulointerstitial abnormality (HP:0001969)1.94392346
150Urticaria (HP:0001025)1.93807778
151Chondrocalcinosis (HP:0000934)1.93586331
152Decreased circulating renin level (HP:0003351)1.92786941
153Hyperammonemia (HP:0001987)1.92689108
154Gaze-evoked nystagmus (HP:0000640)1.91565022
155Abnormality of eosinophils (HP:0001879)1.90737744
156Pustule (HP:0200039)1.90424729
157Increased IgE level (HP:0003212)1.89639587
158Abnormality of the pleura (HP:0002103)1.89365325
159Peritonitis (HP:0002586)1.88338112
160Abnormality of alanine metabolism (HP:0010916)1.88212118
161Hyperalaninemia (HP:0003348)1.88212118
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88212118
163Cheilitis (HP:0100825)1.87518852
164Keratitis (HP:0000491)1.87109259
165Abnormality of Sharpey fibers (HP:0100685)1.86398457
166Spontaneous hematomas (HP:0007420)1.85971756
167Metaphyseal irregularity (HP:0003025)1.84959307
168Methylmalonic aciduria (HP:0012120)1.84510050
169Interstitial pulmonary disease (HP:0006530)1.83698691
170Glomerulosclerosis (HP:0000096)1.83191670
171Vertigo (HP:0002321)1.82630491
172Eosinophilia (HP:0001880)1.81407473
173Bicornuate uterus (HP:0000813)1.81379280
174Panhypogammaglobulinemia (HP:0003139)1.81329453
175Abnormality of the pericardium (HP:0001697)1.81226923
176Arterial thrombosis (HP:0004420)1.80034219
177Protruding tongue (HP:0010808)1.79721941
178Hypotension (HP:0002615)1.79712031
179Abnormal tarsal ossification (HP:0008369)1.78375912
180Pulmonary embolism (HP:0002204)1.75900133
181Cystic liver disease (HP:0006706)1.75488468
182Lymphangioma (HP:0100764)1.75018867
183Gingivitis (HP:0000230)1.71851300
184Microcytic anemia (HP:0001935)1.71147277
185Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71002541
186Lethargy (HP:0001254)1.70799681
187Abnormality of the costochondral junction (HP:0000919)1.70744557
188Abnormality of the renal cortex (HP:0011035)1.70357625
189Hyperphosphatemia (HP:0002905)1.70122422
190Sensorimotor neuropathy (HP:0007141)1.68147987
191Abnormality of carpal bone ossification (HP:0006257)1.65778816
192Abnormality of sulfur amino acid metabolism (HP:0004339)1.63978542
193Generalized muscle weakness (HP:0003324)1.62734840
194Abnormality of calcium-phosphate metabolism (HP:0100530)1.59960712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.80345874
2WNK37.25102629
3OXSR17.00098261
4STK394.41500780
5TAOK33.44600341
6RIPK43.13979126
7STK38L2.89058781
8TXK2.66215277
9IRAK42.62545637
10BCKDK2.46037730
11ACVR1B2.30497216
12MAP4K12.14101616
13ADRBK22.05882542
14CSK2.02632111
15FES2.00993590
16WNK11.91808768
17BMPR1B1.88445389
18MST41.80052964
19IKBKE1.69924755
20SGK4941.68570360
21SGK2231.68570360
22MST1R1.68551889
23GRK11.65214801
24CAMKK21.59097993
25PDK31.57551733
26PDK41.57551733
27SYK1.54502173
28TLK11.48828111
29TYK21.43620344
30TNK21.41168586
31ZAP701.35848160
32PDK21.34943718
33HCK1.33481695
34BTK1.31377046
35LYN1.31148546
36KIT1.30881350
37ADRBK11.28609014
38EPHB11.28374028
39STK381.22076469
40MAP3K31.19512476
41JAK31.18038338
42FGR1.15274247
43IKBKB1.15266013
44MATK1.13738350
45TEC1.10416144
46FGFR41.08820023
47TIE11.08509533
48MAPK131.08043225
49LRRK21.06772277
50FER1.02003229
51TGFBR21.01519431
52ZAK0.99749175
53SGK20.99183712
54JAK10.98272468
55SGK30.97612763
56INSRR0.97240890
57LCK0.96784352
58SIK20.93419646
59ITK0.91212816
60NEK10.91014407
61MAP3K140.89356792
62LATS10.88810250
63MAPK150.87766820
64MAP2K40.85426015
65GSK3A0.84186208
66MAP3K110.82765346
67MAP2K60.80950941
68GRK70.79942179
69PTK20.78918688
70CSF1R0.78059073
71RPS6KA60.77171686
72MAP4K20.76214514
73ERN10.75260802
74NUAK10.74587850
75CDK190.74476579
76TAOK10.74059307
77MAP3K70.73890197
78MARK30.72027532
79TBK10.69797741
80FRK0.69249233
81NLK0.68424110
82MYLK0.65828625
83PINK10.64367837
84MAP3K60.63460934
85RIPK10.62198120
86PAK40.62046509
87PIM10.61091542
88YES10.59002299
89EPHB20.58447546
90SGK10.58355018
91GRK50.57759347
92DYRK1B0.52964693
93ERBB20.52640451
94FGFR20.52363478
95MET0.51416826
96MARK20.50061213
97CAMKK10.49648600
98PTK60.49153953
99STK240.48515894
100PTK2B0.48123389
101PRKAA20.46591835
102PRKD20.44761694
103FYN0.43796063
104SIK10.43658506
105DYRK30.43655386
106MAP3K20.42865189
107SIK30.42564307
108HIPK20.41412971
109PRKCI0.40663662
110PDPK10.40564171
111GRK60.40538682
112STK100.39254575
113IRAK30.38242106
114PNCK0.37481979
115TNIK0.37430303
116CAMK40.37151390
117ABL20.37031241
118DYRK20.36997236
119RPS6KA50.35771818
120PRKAA10.35008689
121CASK0.34547529
122DAPK20.32106022
123PAK30.31859848
124MAP2K30.31385731
125EPHA30.29669639
126MAPK110.27375341
127IRAK10.26659766
128PRKCZ0.23846977
129PRKCD0.23560935
130NME10.23163654
131EPHA20.22586836
132NTRK10.22197781
133STK30.21521166
134CAMK1G0.21328169
135MAP2K10.21207499
136MAP2K20.17284019
137INSR0.14691921
138ROCK10.13967771
139KDR0.13834153
140BLK0.13488921
141IGF1R0.13266891
142STK110.12874030
143EPHA40.12499044
144PRKACA0.12438903
145PRKCA0.11925059
146PDK10.11583820
147PRKACG0.11427363
148PRKCE0.10911944
149ERBB40.10833420
150CAMK1D0.10719509
151TRPM70.10182696
152PRKCH0.09823399
153SRC0.09699725
154DDR20.09178919
155CHUK0.08207114
156PDGFRB0.08067040
157ABL10.08032200
158PIK3CG0.07669241
159FGFR30.07368489
160ROCK20.07316768
161PRKCQ0.07207524
162JAK20.07010455
163TAOK20.06437757

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.56346953
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.54500484
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38768630
4Pentose and glucuronate interconversions_Homo sapiens_hsa000403.33487330
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.32392345
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14348969
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.03465576
8Propanoate metabolism_Homo sapiens_hsa006403.02479138
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71222734
10Collecting duct acid secretion_Homo sapiens_hsa049662.61588846
11Peroxisome_Homo sapiens_hsa041462.42113361
12Autoimmune thyroid disease_Homo sapiens_hsa053202.36653860
13Vitamin digestion and absorption_Homo sapiens_hsa049772.27357625
14Staphylococcus aureus infection_Homo sapiens_hsa051502.25996460
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23043485
16Pyruvate metabolism_Homo sapiens_hsa006202.21909606
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21498415
18Leishmaniasis_Homo sapiens_hsa051402.18498395
19Fatty acid degradation_Homo sapiens_hsa000712.18086747
20Sulfur metabolism_Homo sapiens_hsa009202.12856029
21Graft-versus-host disease_Homo sapiens_hsa053322.12485469
22Intestinal immune network for IgA production_Homo sapiens_hsa046722.08322876
23Tryptophan metabolism_Homo sapiens_hsa003802.07277028
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06838323
25Linoleic acid metabolism_Homo sapiens_hsa005912.06686270
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97224538
27Primary immunodeficiency_Homo sapiens_hsa053401.95554862
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92708625
29Osteoclast differentiation_Homo sapiens_hsa043801.91470361
30beta-Alanine metabolism_Homo sapiens_hsa004101.91369871
31Allograft rejection_Homo sapiens_hsa053301.89794827
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84336264
33Glutathione metabolism_Homo sapiens_hsa004801.80661135
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77856881
35Mineral absorption_Homo sapiens_hsa049781.76699290
36Fatty acid metabolism_Homo sapiens_hsa012121.63215850
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54560469
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53506888
39Nicotine addiction_Homo sapiens_hsa050331.51907181
40Bile secretion_Homo sapiens_hsa049761.50049766
41Type I diabetes mellitus_Homo sapiens_hsa049401.49725202
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49126686
43Protein digestion and absorption_Homo sapiens_hsa049741.45310791
44Tuberculosis_Homo sapiens_hsa051521.44902679
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.43504798
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41155849
47Ether lipid metabolism_Homo sapiens_hsa005651.40910726
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40426267
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39258406
50Arginine and proline metabolism_Homo sapiens_hsa003301.38480551
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38447570
52Hematopoietic cell lineage_Homo sapiens_hsa046401.37747727
53Other glycan degradation_Homo sapiens_hsa005111.36575493
54Malaria_Homo sapiens_hsa051441.34394560
55Asthma_Homo sapiens_hsa053101.33532074
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29285638
57Morphine addiction_Homo sapiens_hsa050321.27240640
58Phototransduction_Homo sapiens_hsa047441.26587001
59Carbon metabolism_Homo sapiens_hsa012001.25184265
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.24615918
61PPAR signaling pathway_Homo sapiens_hsa033201.24580471
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22899962
63Chemokine signaling pathway_Homo sapiens_hsa040621.20910257
64B cell receptor signaling pathway_Homo sapiens_hsa046621.19393295
65Measles_Homo sapiens_hsa051621.18767161
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18388780
67Starch and sucrose metabolism_Homo sapiens_hsa005001.18122819
68Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17646131
69Dorso-ventral axis formation_Homo sapiens_hsa043201.16341429
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15513425
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11747876
72Lysine degradation_Homo sapiens_hsa003101.11481246
73T cell receptor signaling pathway_Homo sapiens_hsa046601.09269802
74Histidine metabolism_Homo sapiens_hsa003401.08608399
75African trypanosomiasis_Homo sapiens_hsa051431.07563117
76Antigen processing and presentation_Homo sapiens_hsa046121.07093822
77Glycerolipid metabolism_Homo sapiens_hsa005611.01933344
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01384268
79Serotonergic synapse_Homo sapiens_hsa047261.00102291
80Taste transduction_Homo sapiens_hsa047420.99458642
81Phenylalanine metabolism_Homo sapiens_hsa003600.96107283
82TNF signaling pathway_Homo sapiens_hsa046680.94643659
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92790240
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87091607
85Olfactory transduction_Homo sapiens_hsa047400.85404971
86Chemical carcinogenesis_Homo sapiens_hsa052040.85250403
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84806664
88Toxoplasmosis_Homo sapiens_hsa051450.83675555
89Platelet activation_Homo sapiens_hsa046110.82460295
90Regulation of autophagy_Homo sapiens_hsa041400.82224542
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.81791372
92Cholinergic synapse_Homo sapiens_hsa047250.81174388
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80036949
94Arginine biosynthesis_Homo sapiens_hsa002200.80003657
95Lysosome_Homo sapiens_hsa041420.79549700
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79351435
97Legionellosis_Homo sapiens_hsa051340.76561383
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75945257
99Thyroid hormone synthesis_Homo sapiens_hsa049180.74050267
100Selenocompound metabolism_Homo sapiens_hsa004500.72469709
101Circadian entrainment_Homo sapiens_hsa047130.72081077
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.71793295
103Influenza A_Homo sapiens_hsa051640.68612166
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.68449118
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68375464
106Glutamatergic synapse_Homo sapiens_hsa047240.67935047
107MAPK signaling pathway_Homo sapiens_hsa040100.66860480
108Fatty acid elongation_Homo sapiens_hsa000620.66173498
109Renin-angiotensin system_Homo sapiens_hsa046140.65467712
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.63270219
111Herpes simplex infection_Homo sapiens_hsa051680.62087898
112Folate biosynthesis_Homo sapiens_hsa007900.61920072
113Arachidonic acid metabolism_Homo sapiens_hsa005900.61403738
114Ovarian steroidogenesis_Homo sapiens_hsa049130.61403098
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59078478
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58893362
117Fructose and mannose metabolism_Homo sapiens_hsa000510.58716417
118Type II diabetes mellitus_Homo sapiens_hsa049300.57613547
119Retinol metabolism_Homo sapiens_hsa008300.56560887
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.56345320
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56132836
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55896996
123GABAergic synapse_Homo sapiens_hsa047270.54467904
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54202237
125cAMP signaling pathway_Homo sapiens_hsa040240.51858660
126Calcium signaling pathway_Homo sapiens_hsa040200.51706416
127* Gastric acid secretion_Homo sapiens_hsa049710.50610814
128Oxidative phosphorylation_Homo sapiens_hsa001900.49986951
129Oxytocin signaling pathway_Homo sapiens_hsa049210.49659170
130Prolactin signaling pathway_Homo sapiens_hsa049170.49257950
131Long-term depression_Homo sapiens_hsa047300.49008962
132Salivary secretion_Homo sapiens_hsa049700.47801814
133Vibrio cholerae infection_Homo sapiens_hsa051100.45304685
134Ras signaling pathway_Homo sapiens_hsa040140.44981740
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44714225
136Fatty acid biosynthesis_Homo sapiens_hsa000610.44619524
137Biosynthesis of amino acids_Homo sapiens_hsa012300.44466546
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.44296733
139Metabolic pathways_Homo sapiens_hsa011000.44213869
140Caffeine metabolism_Homo sapiens_hsa002320.43527777
141Pertussis_Homo sapiens_hsa051330.43264914
142ECM-receptor interaction_Homo sapiens_hsa045120.42917830
143Viral myocarditis_Homo sapiens_hsa054160.40991289
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40368193
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.40177376
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.33214101
147Sphingolipid metabolism_Homo sapiens_hsa006000.33179879
148ABC transporters_Homo sapiens_hsa020100.33048351
149Rheumatoid arthritis_Homo sapiens_hsa053230.31644453
150Tyrosine metabolism_Homo sapiens_hsa003500.31518690
151Pentose phosphate pathway_Homo sapiens_hsa000300.28295941
152Choline metabolism in cancer_Homo sapiens_hsa052310.27933200
153Nitrogen metabolism_Homo sapiens_hsa009100.25499782
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24154216
155Steroid biosynthesis_Homo sapiens_hsa001000.21117035
156Sulfur relay system_Homo sapiens_hsa041220.18297016
157Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17118722
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.15584355
159Synaptic vesicle cycle_Homo sapiens_hsa047210.15000583
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13122741
161alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12459470
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.11968672
163Inositol phosphate metabolism_Homo sapiens_hsa005620.11578485
164Phagosome_Homo sapiens_hsa041450.10501536
165Insulin resistance_Homo sapiens_hsa049310.10495360
166Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09526106
167Focal adhesion_Homo sapiens_hsa045100.08043290
168Bladder cancer_Homo sapiens_hsa052190.07740620
169Hepatitis C_Homo sapiens_hsa051600.07648678
170Tight junction_Homo sapiens_hsa045300.06906986
171Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06662813
172Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.04086637
173Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03960277
174Parkinsons disease_Homo sapiens_hsa050120.00371491
175AMPK signaling pathway_Homo sapiens_hsa041520.00061622

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