KCNJ16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.43521866
2urate metabolic process (GO:0046415)8.78552230
3drug transmembrane transport (GO:0006855)8.76249288
4organic cation transport (GO:0015695)7.50709107
5drug transport (GO:0015893)7.43230528
6nephron tubule formation (GO:0072079)7.19481350
7phosphate ion transport (GO:0006817)7.09759041
8lysine metabolic process (GO:0006553)7.06326323
9lysine catabolic process (GO:0006554)7.06326323
10negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.59349784
11mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.57077516
12membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.48904777
13thyroid gland development (GO:0030878)6.23741507
14renal absorption (GO:0070293)6.07278903
15regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033396.05624719
16regulation of apoptotic process involved in morphogenesis (GO:1902337)5.99623486
17phosphate ion transmembrane transport (GO:0035435)5.97834320
18excretion (GO:0007588)5.97161200
19regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.88832995
20quaternary ammonium group transport (GO:0015697)5.85701042
21negative regulation of metanephros development (GO:0072217)5.84621041
22membrane repolarization during action potential (GO:0086011)5.84402528
23cysteine metabolic process (GO:0006534)5.55469666
24response to mercury ion (GO:0046689)5.39540690
25response to lead ion (GO:0010288)5.35277039
26drug catabolic process (GO:0042737)5.30104868
27metanephric nephron tubule development (GO:0072234)5.30027122
28metanephric tubule development (GO:0072170)5.30027122
29exogenous drug catabolic process (GO:0042738)5.28226038
30regulation of mesenchymal cell apoptotic process (GO:2001053)5.14475889
31nonribosomal peptide biosynthetic process (GO:0019184)5.11320804
32glyoxylate metabolic process (GO:0046487)5.07132520
33toxin transport (GO:1901998)5.05458996
34pattern specification involved in kidney development (GO:0061004)5.03191778
35vitamin D metabolic process (GO:0042359)4.98726559
36sulfate transmembrane transport (GO:1902358)4.97527672
37aspartate family amino acid catabolic process (GO:0009068)4.95401976
38metanephric nephron epithelium development (GO:0072243)4.85792233
39tricarboxylic acid metabolic process (GO:0072350)4.75691264
40glutathione biosynthetic process (GO:0006750)4.56998406
41short-chain fatty acid metabolic process (GO:0046459)4.56875622
42glycoside metabolic process (GO:0016137)4.49620930
43metanephric epithelium development (GO:0072207)4.48253734
44modified amino acid transport (GO:0072337)4.45354332
45branched-chain amino acid metabolic process (GO:0009081)4.39232837
46carnitine transport (GO:0015879)4.38465917
47amino-acid betaine transport (GO:0015838)4.38465917
48valine metabolic process (GO:0006573)4.38200117
49trivalent inorganic anion homeostasis (GO:0072506)4.36727167
50phosphate ion homeostasis (GO:0055062)4.36727167
51sulfate transport (GO:0008272)4.33586777
52nephron tubule development (GO:0072080)4.30834008
53homocysteine metabolic process (GO:0050667)4.28462774
54membrane repolarization (GO:0086009)4.15238668
55cellular modified amino acid catabolic process (GO:0042219)4.08876428
56polyol transport (GO:0015791)4.04457532
57mesonephros development (GO:0001823)4.04300020
58negative regulation of kidney development (GO:0090185)4.00745782
59collecting duct development (GO:0072044)4.00717750
60cardiovascular system development (GO:0072358)3.99226272
61urogenital system development (GO:0001655)3.97753950
62regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.97044773
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95797270
64positive regulation of hormone metabolic process (GO:0032352)3.91027626
65relaxation of cardiac muscle (GO:0055119)3.88218531
66amino-acid betaine metabolic process (GO:0006577)3.80558147
67renal tubule development (GO:0061326)3.80507857
68oligosaccharide catabolic process (GO:0009313)3.74977833
69potassium ion import (GO:0010107)3.74625236
70positive regulation of cellular amine metabolic process (GO:0033240)3.74339340
71peptide biosynthetic process (GO:0043043)3.73684559
72fructose metabolic process (GO:0006000)3.71417023
73glutamate metabolic process (GO:0006536)3.70956320
74sodium ion export (GO:0071436)3.70911466
75carnitine metabolic process (GO:0009437)3.67587967
76cellular potassium ion homeostasis (GO:0030007)3.67105497
77branched-chain amino acid catabolic process (GO:0009083)3.66870510
78indole-containing compound catabolic process (GO:0042436)3.63965854
79indolalkylamine catabolic process (GO:0046218)3.63965854
80tryptophan catabolic process (GO:0006569)3.63965854
81serine family amino acid catabolic process (GO:0009071)3.63490157
822-oxoglutarate metabolic process (GO:0006103)3.63374885
83regulation of stem cell maintenance (GO:2000036)3.60816965
84mesenchymal to epithelial transition (GO:0060231)3.60078957
85aromatic amino acid family catabolic process (GO:0009074)3.55562454
86proline metabolic process (GO:0006560)3.53844759
87regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.53480562
88positive regulation of digestive system process (GO:0060456)3.52829686
89fatty acid beta-oxidation (GO:0006635)3.51433853
90nephron epithelium development (GO:0072009)3.45052607
91nephron tubule morphogenesis (GO:0072078)3.45021064
92nephron epithelium morphogenesis (GO:0072088)3.45021064
93sulfur compound transport (GO:0072348)3.44914342
94response to parathyroid hormone (GO:0071107)3.44000286
95sodium-independent organic anion transport (GO:0043252)3.43837175
96embryonic epithelial tube formation (GO:0001838)3.42748871
97sodium ion transport (GO:0006814)3.41430373
98positive regulation of metanephros development (GO:0072216)3.40818662
99lipid oxidation (GO:0034440)3.40476777
100vitamin transport (GO:0051180)3.40368134
101serine family amino acid metabolic process (GO:0009069)3.39746292
102tryptophan metabolic process (GO:0006568)3.39421429
103cochlea development (GO:0090102)3.39379021
104cellular response to gonadotropin stimulus (GO:0071371)3.38524157
105peptide catabolic process (GO:0043171)3.37982202
106L-phenylalanine metabolic process (GO:0006558)3.36702366
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36702366
108fatty acid oxidation (GO:0019395)3.36159548
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.35332242
110L-phenylalanine catabolic process (GO:0006559)3.35332242
111positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.33255737
112response to phenylpropanoid (GO:0080184)3.29504058
113response to lipoprotein particle (GO:0055094)3.29223674
114epithelial tube formation (GO:0072175)3.26350439
115potassium ion homeostasis (GO:0055075)3.25646387
116negative regulation of hormone biosynthetic process (GO:0032353)3.25484087
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25312923
118inositol metabolic process (GO:0006020)3.23655041
119positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.22337970
120cellular ketone body metabolic process (GO:0046950)3.21569515
121glutathione metabolic process (GO:0006749)3.19848057
122glutathione derivative metabolic process (GO:1901685)3.13929127
123glutathione derivative biosynthetic process (GO:1901687)3.13929127
124cellular amino acid catabolic process (GO:0009063)3.13127818
125regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.11690230
126cellular sodium ion homeostasis (GO:0006883)3.10604482
127positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.06102896
128sodium ion homeostasis (GO:0055078)3.05176399
129bicarbonate transport (GO:0015701)3.04363174
130acetyl-CoA metabolic process (GO:0006084)3.00268012
131actin filament depolymerization (GO:0030042)2.99728310
132hydrogen peroxide catabolic process (GO:0042744)2.99288454
133alpha-amino acid catabolic process (GO:1901606)2.99281406
134cellular response to vitamin D (GO:0071305)2.98958524
135positive regulation of mesonephros development (GO:0061213)2.96115958
136specification of organ identity (GO:0010092)2.94853850
137indole-containing compound metabolic process (GO:0042430)2.93638544
138negative regulation of hormone metabolic process (GO:0032351)2.92596225
139transepithelial transport (GO:0070633)2.89705046
140regulation of protein localization to cell surface (GO:2000008)2.88451753
141cobalamin metabolic process (GO:0009235)2.88356136
142hyperosmotic salinity response (GO:0042538)2.88345162
143glutamine family amino acid catabolic process (GO:0009065)2.87853044
144response to water (GO:0009415)2.87276364
145fatty acid catabolic process (GO:0009062)2.85628766
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85056994
147sulfur amino acid catabolic process (GO:0000098)2.84949118
148L-ascorbic acid metabolic process (GO:0019852)2.84720281
149negative regulation of smooth muscle cell differentiation (GO:0051151)2.84055583
150regulation of mesonephros development (GO:0061217)2.83080677
151negative regulation of microtubule polymerization (GO:0031115)2.82681557
152renal tubule morphogenesis (GO:0061333)2.81975533
153one-carbon compound transport (GO:0019755)2.80781999
154carboxylic acid catabolic process (GO:0046395)2.80745980
155organic acid catabolic process (GO:0016054)2.80745980
156dicarboxylic acid biosynthetic process (GO:0043650)2.79951729
157positive regulation of potassium ion transmembrane transport (GO:1901381)2.75316470
158cell communication by electrical coupling (GO:0010644)2.75097625
159flavonoid metabolic process (GO:0009812)2.66404313
160positive regulation of glycogen biosynthetic process (GO:0045725)2.65335945
161inorganic anion transport (GO:0015698)2.64346782
162phenol-containing compound metabolic process (GO:0018958)2.63721687
163cell volume homeostasis (GO:0006884)2.60137068
164cellular anion homeostasis (GO:0030002)2.59349239
165regulation of metanephros development (GO:0072215)2.58529267
166axonemal dynein complex assembly (GO:0070286)2.57400639
167chloride transmembrane transport (GO:1902476)2.55963038
168regulation of potassium ion transmembrane transporter activity (GO:1901016)2.51560522
169positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.47356765
170positive regulation of glycogen metabolic process (GO:0070875)2.43769994
171thymus development (GO:0048538)2.42972658
172thyroid hormone generation (GO:0006590)13.7540818
173thyroid hormone metabolic process (GO:0042403)11.4020532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83764356
2ESR1_21235772_ChIP-Seq_MCF-7_Human2.68090036
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.66655714
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.40636598
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.36929757
6GBX2_23144817_ChIP-Seq_PC3_Human2.20999810
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.06237214
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03548285
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.00848898
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91079773
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88747772
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84475856
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83392093
14PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80467812
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.77701942
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76922271
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76606538
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74845721
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70122483
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69476694
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69476694
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63740065
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63225952
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.57825776
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55235661
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54065857
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53779446
28* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53499579
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52839100
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51765493
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50443490
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49297683
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49029403
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48506203
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.48377342
36VDR_22108803_ChIP-Seq_LS180_Human1.46121294
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.45665729
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.38980492
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36204282
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34840828
41SMAD3_21741376_ChIP-Seq_HESCs_Human1.34626153
42AHR_22903824_ChIP-Seq_MCF-7_Human1.32975224
43* RXR_22108803_ChIP-Seq_LS180_Human1.32025942
44REST_21632747_ChIP-Seq_MESCs_Mouse1.31572804
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31511897
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.31013553
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30577961
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29249965
49DROSHA_22980978_ChIP-Seq_HELA_Human1.28919826
50RNF2_27304074_Chip-Seq_NSC_Mouse1.28666360
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27728217
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26574267
53* STAT3_23295773_ChIP-Seq_U87_Human1.25151767
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24838982
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23006028
56TAF15_26573619_Chip-Seq_HEK293_Human1.22734071
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.20755652
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20583628
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.20149281
60* BCAT_22108803_ChIP-Seq_LS180_Human1.19889993
61FUS_26573619_Chip-Seq_HEK293_Human1.18318865
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.17545252
63AR_21572438_ChIP-Seq_LNCaP_Human1.17499573
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17147486
65SMAD4_21741376_ChIP-Seq_HESCs_Human1.16220926
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16190028
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.16018710
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15851158
69TCF4_23295773_ChIP-Seq_U87_Human1.15458315
70TP53_16413492_ChIP-PET_HCT116_Human1.14888698
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13849914
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11786897
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11248230
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.09190957
75* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08911608
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07969103
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06779333
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06652401
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05723136
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05390985
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05019362
82EZH2_22144423_ChIP-Seq_EOC_Human1.03296509
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02930488
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02764255
85AR_25329375_ChIP-Seq_VCAP_Human1.02595757
86* FOXA2_19822575_ChIP-Seq_HepG2_Human1.02580786
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02507026
88CLOCK_20551151_ChIP-Seq_293T_Human1.02065363
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.01976537
90RUNX2_22187159_ChIP-Seq_PCA_Human1.01931396
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01811089
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.01771640
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01005626
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00744638
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99785005
96ISL1_27105846_Chip-Seq_CPCs_Mouse0.99544571
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99219831
98TP53_18474530_ChIP-ChIP_U2OS_Human0.98714354
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98581417
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98419991
101VDR_24787735_ChIP-Seq_THP-1_Human0.97817671
102REST_18959480_ChIP-ChIP_MESCs_Mouse0.97313710
103RNF2_27304074_Chip-Seq_ESCs_Mouse0.95482277
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95231196
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94654833
106ZNF274_21170338_ChIP-Seq_K562_Hela0.94345569
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93741223
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93677955
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93581420
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93463035
111* P300_19829295_ChIP-Seq_ESCs_Human0.93347479
112* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92705952
113RING1B_27294783_Chip-Seq_ESCs_Mouse0.91685105
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91504129
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91278265
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90853409
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90853409
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.89880428
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89094215
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88840701
121GATA4_25053715_ChIP-Seq_YYC3_Human0.87845014
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87304507
123* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87279030
124* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84439976
125HNF4A_19822575_ChIP-Seq_HepG2_Human0.84157482
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.84108279
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83822326
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83797917
129EGR1_19032775_ChIP-ChIP_M12_Human0.83610539
130SOX2_20726797_ChIP-Seq_SW620_Human0.83538829
131TP63_23658742_ChIP-Seq_EP156T_Human0.82719355
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.82685705
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82670348
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82456614
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81869747
136* TCF4_22108803_ChIP-Seq_LS180_Human0.80469050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.09361453
2MP0005360_urolithiasis6.15597017
3MP0004019_abnormal_vitamin_homeostasis4.60866599
4MP0005332_abnormal_amino_acid4.58634490
5MP0000681_abnormal_thyroid_gland4.53815787
6MP0003878_abnormal_ear_physiology4.32961358
7MP0005377_hearing/vestibular/ear_phenot4.32961358
8MP0003195_calcinosis3.66148336
9MP0001765_abnormal_ion_homeostasis3.63587705
10MP0009643_abnormal_urine_homeostasis3.53055035
11MP0002139_abnormal_hepatobiliary_system3.44869059
12MP0002138_abnormal_hepatobiliary_system3.42049422
13MP0001756_abnormal_urination3.15030918
14MP0001958_emphysema2.95481926
15MP0004885_abnormal_endolymph2.90546959
16MP0005636_abnormal_mineral_homeostasis2.78511896
17MP0002136_abnormal_kidney_physiology2.75377465
18MP0002909_abnormal_adrenal_gland2.68563714
19MP0000383_abnormal_hair_follicle2.60445525
20MP0008875_abnormal_xenobiotic_pharmacok2.36204885
21MP0000516_abnormal_urinary_system2.17342639
22MP0005367_renal/urinary_system_phenotyp2.17342639
23MP0010678_abnormal_skin_adnexa1.97509927
24MP0003252_abnormal_bile_duct1.85172768
25MP0002938_white_spotting1.81306259
26MP0008961_abnormal_basal_metabolism1.77123807
27MP0001501_abnormal_sleep_pattern1.72435748
28MP0005365_abnormal_bile_salt1.67024858
29MP0005058_abnormal_lysosome_morphology1.66584473
30MP0000538_abnormal_urinary_bladder1.66349546
31MP0002876_abnormal_thyroid_physiology1.65181269
32MP0001270_distended_abdomen1.57899277
33MP0001485_abnormal_pinna_reflex1.57305238
34MP0003938_abnormal_ear_development1.52039153
35MP0003186_abnormal_redox_activity1.48098173
36MP0005085_abnormal_gallbladder_physiolo1.42193001
37MP0005584_abnormal_enzyme/coenzyme_acti1.39571458
38MP0002168_other_aberrant_phenotype1.28817905
39MP0003300_gastrointestinal_ulcer1.24593873
40MP0004858_abnormal_nervous_system1.22345654
41MP0002089_abnormal_postnatal_growth/wei1.18109710
42MP0000230_abnormal_systemic_arterial1.15420403
43MP0005670_abnormal_white_adipose1.13258272
44MP0002928_abnormal_bile_duct1.09205439
45MP0005084_abnormal_gallbladder_morpholo1.07317228
46MP0008569_lethality_at_weaning1.06796816
47MP0005535_abnormal_body_temperature1.03782082
48MP0003690_abnormal_glial_cell1.03486493
49MP0009250_abnormal_appendicular_skeleto0.98499321
50MP0003879_abnormal_hair_cell0.97079092
51MP0005451_abnormal_body_composition0.94322154
52MP0001963_abnormal_hearing_physiology0.94293937
53MP0000631_abnormal_neuroendocrine_gland0.93083873
54MP0002135_abnormal_kidney_morphology0.92224666
55MP0004742_abnormal_vestibular_system0.91922068
56MP0002653_abnormal_ependyma_morphology0.91435615
57MP0005319_abnormal_enzyme/_coenzyme0.90982883
58MP0001984_abnormal_olfaction0.90242582
59MP0005666_abnormal_adipose_tissue0.86648676
60MP0002896_abnormal_bone_mineralization0.82948345
61MP0005220_abnormal_exocrine_pancreas0.82937476
62MP0003638_abnormal_response/metabolism_0.81883555
63MP0005167_abnormal_blood-brain_barrier0.80512209
64MP0008872_abnormal_physiological_respon0.79940294
65MP0009046_muscle_twitch0.79623011
66MP0003646_muscle_fatigue0.79319809
67MP0003183_abnormal_peptide_metabolism0.78438168
68MP0009764_decreased_sensitivity_to0.77422085
69MP0009780_abnormal_chondrocyte_physiolo0.77176903
70MP0004147_increased_porphyrin_level0.76570908
71MP0005165_increased_susceptibility_to0.76340469
72MP0000678_abnormal_parathyroid_gland0.76091589
73MP0003329_amyloid_beta_deposits0.74817192
74MP0002064_seizures0.73247754
75MP0003283_abnormal_digestive_organ0.72987125
76MP0003633_abnormal_nervous_system0.72507724
77MP0004133_heterotaxia0.72497818
78MP0010386_abnormal_urinary_bladder0.72116229
79MP0003172_abnormal_lysosome_physiology0.71664323
80MP0000026_abnormal_inner_ear0.71496988
81MP0001177_atelectasis0.69231433
82MP0002118_abnormal_lipid_homeostasis0.68131808
83MP0001486_abnormal_startle_reflex0.67739772
84MP0005508_abnormal_skeleton_morphology0.65830757
85MP0004270_analgesia0.65720079
86MP0001664_abnormal_digestion0.65604531
87MP0003136_yellow_coat_color0.65344717
88MP0001440_abnormal_grooming_behavior0.64843528
89MP0002067_abnormal_sensory_capabilities0.64098965
90MP0001666_abnormal_nutrient_absorption0.64054292
91MP0006036_abnormal_mitochondrial_physio0.63761413
92MP0002638_abnormal_pupillary_reflex0.63282597
93MP0000778_abnormal_nervous_system0.62585725
94MP0004215_abnormal_myocardial_fiber0.62555590
95MP0000566_synostosis0.61404179
96MP0009384_cardiac_valve_regurgitation0.60991366
97MP0008004_abnormal_stomach_pH0.60329810
98MP0001502_abnormal_circadian_rhythm0.58882254
99MP0005423_abnormal_somatic_nervous0.58504701
100MP0009745_abnormal_behavioral_response0.57324341
101MP0002108_abnormal_muscle_morphology0.56778514
102MP0002735_abnormal_chemical_nociception0.56720101
103MP0001764_abnormal_homeostasis0.56581950
104MP0003075_altered_response_to0.56492033
105MP0005646_abnormal_pituitary_gland0.56392210
106MP0000163_abnormal_cartilage_morphology0.56057571
107MP0005395_other_phenotype0.55717472
108MP0001944_abnormal_pancreas_morphology0.55656975
109MP0009642_abnormal_blood_homeostasis0.55415901
110MP0003941_abnormal_skin_development0.54667962
111MP0002069_abnormal_eating/drinking_beha0.54102227
112MP0002249_abnormal_larynx_morphology0.54093099
113MP0001968_abnormal_touch/_nociception0.52877851
114MP0003045_fibrosis0.52435275
115MP0002572_abnormal_emotion/affect_behav0.52362216
116MP0000462_abnormal_digestive_system0.51929278
117MP0002796_impaired_skin_barrier0.50480688
118MP0000920_abnormal_myelination0.50365699
119MP0002932_abnormal_joint_morphology0.50245415
120MP0002272_abnormal_nervous_system0.49846111
121MP0002736_abnormal_nociception_after0.48866492
122MP0001661_extended_life_span0.48508576
123MP0002115_abnormal_skeleton_extremities0.47868978
124MP0002734_abnormal_mechanical_nocicepti0.47834845
125MP0004134_abnormal_chest_morphology0.47772385
126MP0003953_abnormal_hormone_level0.46977998
127MP0000534_abnormal_ureter_morphology0.46265956
128MP0004484_altered_response_of0.45904326
129MP0002063_abnormal_learning/memory/cond0.45610673
130MP0005595_abnormal_vascular_smooth0.45498018
131MP0001731_abnormal_postnatal_growth0.44865774
132MP0002998_abnormal_bone_remodeling0.44373171
133MP0000049_abnormal_middle_ear0.43865721
134MP0002229_neurodegeneration0.43509948
135MP0002116_abnormal_craniofacial_bone0.43097650
136MP0003631_nervous_system_phenotype0.42972536
137MP0006276_abnormal_autonomic_nervous0.42451434
138MP0003191_abnormal_cellular_cholesterol0.41805854
139MP0004859_abnormal_synaptic_plasticity0.41784018
140MP0003943_abnormal_hepatobiliary_system0.41744320
141MP0003634_abnormal_glial_cell0.41415491
142MP0003942_abnormal_urinary_system0.41293447
143MP0004264_abnormal_extraembryonic_tissu0.41185873
144MP0010329_abnormal_lipoprotein_level0.41180184
145MP0005503_abnormal_tendon_morphology0.40731329
146MP0009703_decreased_birth_body0.39994958

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.75632660
2Metabolic alkalosis (HP:0200114)8.33302674
3Hypokalemic alkalosis (HP:0001949)8.11743610
4Hypomagnesemia (HP:0002917)7.59552275
5Hyperactive renin-angiotensin system (HP:0000841)7.43795815
6Polyuria (HP:0000103)7.14980045
7Abnormal urine output (HP:0012590)6.84954103
8Thyroid-stimulating hormone excess (HP:0002925)6.56945276
9Abnormality of chloride homeostasis (HP:0011422)6.53481789
10Abnormality of renal excretion (HP:0011036)6.47709773
11Abnormality of magnesium homeostasis (HP:0004921)6.37800966
12Gout (HP:0001997)6.24606795
13Goiter (HP:0000853)6.12350829
14Abnormal drinking behavior (HP:0030082)5.98514914
15Polydipsia (HP:0001959)5.98514914
16Hyperaldosteronism (HP:0000859)5.47118355
17Hyperphosphatemia (HP:0002905)5.43963230
18Tetany (HP:0001281)5.43511685
19Abnormality of renin-angiotensin system (HP:0000847)5.33714303
20Renal salt wasting (HP:0000127)5.30837945
21Alkalosis (HP:0001948)5.01533193
22Proximal tubulopathy (HP:0000114)4.75282681
23Hyperuricemia (HP:0002149)4.52025420
24Increased purine levels (HP:0004368)4.52025420
25Hyperglycinuria (HP:0003108)4.30705747
26Hypercalciuria (HP:0002150)4.06834530
27Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04842067
28Hypokalemia (HP:0002900)4.02427093
29Renal tubular acidosis (HP:0001947)3.89641115
30Abnormality of purine metabolism (HP:0004352)3.84635483
31Congenital sensorineural hearing impairment (HP:0008527)3.60510262
32Abnormality of glycine metabolism (HP:0010895)3.48844214
33Abnormality of serine family amino acid metabolism (HP:0010894)3.48844214
34Abnormality of potassium homeostasis (HP:0011042)3.34027100
35Hypothermia (HP:0002045)3.31382461
36Ketoacidosis (HP:0001993)3.28716920
37Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)3.25764340
38Generalized aminoaciduria (HP:0002909)3.23431796
39Abnormality of urine glucose concentration (HP:0011016)3.13382739
40Glycosuria (HP:0003076)3.13382739
41Alacrima (HP:0000522)3.03202795
42Nephrocalcinosis (HP:0000121)3.02161413
43Abnormality of cochlea (HP:0000375)2.91783789
44Hydroxyprolinuria (HP:0003080)2.84407089
45Abnormality of proline metabolism (HP:0010907)2.84407089
46Hyperphosphaturia (HP:0003109)2.78337839
47Hyperthyroidism (HP:0000836)2.75523996
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.73401263
49Confusion (HP:0001289)2.72893910
50Abnormality of nucleobase metabolism (HP:0010932)2.68274794
51Abnormal urine phosphate concentration (HP:0012599)2.66916058
52Abnormality of fatty-acid metabolism (HP:0004359)2.62607128
53Ketosis (HP:0001946)2.61820759
54Potter facies (HP:0002009)2.57620033
55Facial shape deformation (HP:0011334)2.57620033
56Delayed epiphyseal ossification (HP:0002663)2.55601083
57Dehydration (HP:0001944)2.52669780
58Abnormality of sodium homeostasis (HP:0010931)2.49173381
59Hypoparathyroidism (HP:0000829)2.48958344
60Adrenal overactivity (HP:0002717)2.48349074
61Widely patent fontanelles and sutures (HP:0004492)2.47313228
62Decreased lacrimation (HP:0000633)2.43058320
63Vascular calcification (HP:0004934)2.42228531
64Pili torti (HP:0003777)2.40981535
65Vacuolated lymphocytes (HP:0001922)2.40821464
66Nephrolithiasis (HP:0000787)2.39728486
67Thyroid carcinoma (HP:0002890)2.39542688
68Hyperglycinemia (HP:0002154)2.37425862
69Renal tubular dysfunction (HP:0000124)2.36200291
70Delayed CNS myelination (HP:0002188)2.36018980
71Small epiphyses (HP:0010585)2.31854156
72Hyponatremia (HP:0002902)2.31239181
73Morphological abnormality of the inner ear (HP:0011390)2.29445032
74Hypophosphatemia (HP:0002148)2.23116710
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22842695
76Intellectual disability, moderate (HP:0002342)2.21589541
77Tubular atrophy (HP:0000092)2.19497875
78Abnormality of renal resorption (HP:0011038)2.15532884
79Tubulointerstitial fibrosis (HP:0005576)2.15079138
80Enlarged kidneys (HP:0000105)2.13317193
81Microretrognathia (HP:0000308)2.12564375
82Rickets (HP:0002748)2.12499487
83Cardiovascular calcification (HP:0011915)2.11328671
84Hyperparathyroidism (HP:0000843)2.07266680
85Nasolacrimal duct obstruction (HP:0000579)2.02944506
86Mixed hearing impairment (HP:0000410)2.01402375
87Hyperammonemia (HP:0001987)1.98704999
88Vomiting (HP:0002013)1.97259118
89Large eyes (HP:0001090)1.97199938
90Bilateral sensorineural hearing impairment (HP:0008619)1.96947671
91Decreased circulating renin level (HP:0003351)1.96033685
92Abnormal eating behavior (HP:0100738)1.94220813
93Chondrocalcinosis (HP:0000934)1.92705799
94Hypothyroidism (HP:0000821)1.91771175
95Hypocalcemia (HP:0002901)1.86677004
96Abnormality of Sharpey fibers (HP:0100685)1.84157790
97Metabolic acidosis (HP:0001942)1.82977199
98Methylmalonic aciduria (HP:0012120)1.82560583
99Abnormal ciliary motility (HP:0012262)1.80933938
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.79962171
101Absent/shortened dynein arms (HP:0200106)1.79962171
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78038113
103Dicarboxylic aciduria (HP:0003215)1.78038113
104Hypotension (HP:0002615)1.77703471
105Hyperpituitarism (HP:0010514)1.75221133
106Abnormality of the renal medulla (HP:0100957)1.74397085
107Abnormality of the lacrimal duct (HP:0011481)1.71485634
108Malnutrition (HP:0004395)1.71014250
109Metaphyseal cupping (HP:0003021)1.70945528
110Abnormal respiratory motile cilium physiology (HP:0012261)1.67173439
111Abnormality of the dental root (HP:0006486)1.66389161
112Taurodontia (HP:0000679)1.66389161
113Abnormality of permanent molar morphology (HP:0011071)1.66389161
114Lethargy (HP:0001254)1.66206993
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66032090
116Abnormal enzyme/coenzyme activity (HP:0012379)1.64523049
117Sensorimotor neuropathy (HP:0007141)1.64348391
118Polyphagia (HP:0002591)1.62746564
119Abnormal respiratory epithelium morphology (HP:0012253)1.61301073
120Abnormal respiratory motile cilium morphology (HP:0005938)1.61301073
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.60633683
122Abnormality of alkaline phosphatase activity (HP:0004379)1.59463751
123Generalized muscle weakness (HP:0003324)1.59282135
124Focal segmental glomerulosclerosis (HP:0000097)1.58785865
125Abnormality of the dental pulp (HP:0006479)1.58684723
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.58312651
127Glomerulosclerosis (HP:0000096)1.57419336
128Bicornuate uterus (HP:0000813)1.56740529
129Pancreatic cysts (HP:0001737)1.55908629
130Preauricular pit (HP:0004467)1.55621651
131Periauricular skin pits (HP:0100277)1.55621651
132Nephrogenic diabetes insipidus (HP:0009806)1.54905167
133Constipation (HP:0002019)1.54742513
134Metaphyseal irregularity (HP:0003025)1.53909832
135Tubulointerstitial abnormality (HP:0001969)1.53184009
136Abnormality of molar (HP:0011077)1.52946651
137Abnormality of molar morphology (HP:0011070)1.52946651
138Abnormality of calcium-phosphate metabolism (HP:0100530)1.52211180
139Thin bony cortex (HP:0002753)1.51210205
140Hyperkalemia (HP:0002153)1.49517404
141Tachypnea (HP:0002789)1.48290308
142Abnormality of the nasolacrimal system (HP:0000614)1.46897290
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.46556624
144Abnormality of the renal cortex (HP:0011035)1.46459604
145Coarse facial features (HP:0000280)1.45888916
146Abnormality of the costochondral junction (HP:0000919)1.45834924
147Hyperventilation (HP:0002883)1.44729979
148Dysostosis multiplex (HP:0000943)1.43100087
149Abnormality of macular pigmentation (HP:0008002)1.37325455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.05035074
2WNK37.92850489
3OXSR17.15262264
4STK394.12833274
5SGK2232.51705350
6SGK4942.51705350
7STK38L2.29190388
8SGK22.07549397
9WNK12.00536341
10AKT31.90973708
11BCKDK1.89331883
12PNCK1.86212360
13SGK31.79364277
14MST41.51510029
15STK381.49060117
16PDK21.48848824
17EPHA21.39479602
18PDK41.33390224
19PDK31.33390224
20MST1R1.29428369
21FRK1.25976618
22MAP3K121.07742774
23NEK11.04863625
24PINK10.96818653
25MUSK0.96067084
26RET0.91240641
27EPHA40.82561009
28SGK10.80896908
29EPHB10.79007694
30MAPK150.78597026
31BMPR1B0.76406561
32NTRK20.75785224
33INSRR0.74495842
34FGFR40.72662188
35GRK10.69803314
36ADRBK20.65023093
37GSK3A0.63966462
38NLK0.62145565
39ERBB20.61655614
40RIPK10.61579898
41LATS10.60316660
42CASK0.59909944
43DAPK20.59003596
44IRAK10.57632223
45IRAK30.57527557
46MAP3K70.54588114
47FER0.54248645
48IRAK20.51803552
49MAP3K20.51783491
50NTRK10.49971967
51TIE10.49942435
52LRRK20.49867920
53TNK20.49307911
54MINK10.48968359
55PRKAA10.47906947
56DDR20.46934648
57NEK60.46620012
58MYLK0.46302465
59PRKD30.46083004
60SIK30.44483215
61PDPK10.44175589
62SIK10.43595051
63PAK30.42818595
64PRKAA20.42280963
65NTRK30.39565989
66PASK0.39021134
67PHKG20.38664763
68PHKG10.38664763
69LMTK20.38421874
70ERBB40.38214749
71MAP2K70.38182740
72MAP3K30.37133632
73PRKCZ0.36348102
74PTK60.35999381
75MAP2K20.35884231
76GRK60.35733952
77MAPK130.34465940
78CSNK1A1L0.33266759
79MAP2K60.32554439
80PRKD20.32546554
81TNIK0.32226497
82PRKCG0.31074921
83MAPK70.30999070
84STK30.30503647
85MAP2K10.29803029
86PKN10.29723452
87PRKCE0.29228422
88PRKCH0.28211020
89MAPK120.27607550
90PRKCA0.27295478
91PTK20.27118950
92STK240.26860576
93CSNK1G20.26804332
94PRKCD0.25555130
95MAP4K20.25483925
96PDK10.24347561
97TRIB30.24326441
98STK110.24174237
99FGFR20.23722713
100ROCK10.23595558
101CAMK1G0.23246949
102PRKACA0.22082308
103DMPK0.22019394
104PRKACG0.21975850
105PAK60.21839519
106MARK10.21285976
107MAPK110.21087754
108CAMKK20.20930173
109CDK50.20843059
110MAP2K40.20479876
111BCR0.20439258
112EPHB20.19308761
113TGFBR20.18070063
114MAPKAPK30.17666671
115PRKG20.17651568
116MAP3K140.17296330
117ERBB30.16906587
118EPHA30.16523815
119PRKCI0.16052595
120ABL20.15926706
121PIK3CA0.15896310
122CSNK1A10.15030483
123FGFR30.15007917
124TRPM70.14914638
125MAP3K40.14465242
126SIK20.13731938
127AKT20.13619938
128TYRO30.12937050
129ADRBK10.12824946
130SRC0.12316227
131IGF1R0.12268943
132DYRK1A0.11748164
133RPS6KA30.11676427
134MET0.11360340
135PRKCQ0.11335833
136ROCK20.11242169

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.27895950
2Butanoate metabolism_Homo sapiens_hsa006503.31119165
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14080683
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.99360249
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82901979
6Propanoate metabolism_Homo sapiens_hsa006402.71924506
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61978635
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59843998
9Collecting duct acid secretion_Homo sapiens_hsa049662.50840233
10Fatty acid degradation_Homo sapiens_hsa000712.40975934
11Nitrogen metabolism_Homo sapiens_hsa009102.40714699
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38620656
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36597507
14Autoimmune thyroid disease_Homo sapiens_hsa053202.29451309
15Peroxisome_Homo sapiens_hsa041462.26819985
16Vitamin digestion and absorption_Homo sapiens_hsa049772.16771873
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01871173
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94803727
19Bile secretion_Homo sapiens_hsa049761.94431932
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87775618
21Fatty acid metabolism_Homo sapiens_hsa012121.85971626
22Pyruvate metabolism_Homo sapiens_hsa006201.85281982
23Sulfur metabolism_Homo sapiens_hsa009201.81155517
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.74026904
25Tryptophan metabolism_Homo sapiens_hsa003801.73689503
26beta-Alanine metabolism_Homo sapiens_hsa004101.70923913
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69423492
28Mineral absorption_Homo sapiens_hsa049781.62175052
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56758661
30Other glycan degradation_Homo sapiens_hsa005111.46958738
31Glutathione metabolism_Homo sapiens_hsa004801.44223898
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37321804
33PPAR signaling pathway_Homo sapiens_hsa033201.34102338
34Protein digestion and absorption_Homo sapiens_hsa049741.31191438
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27316263
36Carbon metabolism_Homo sapiens_hsa012001.25167940
37Arginine and proline metabolism_Homo sapiens_hsa003301.19551378
38Arginine biosynthesis_Homo sapiens_hsa002201.15481713
39ECM-receptor interaction_Homo sapiens_hsa045121.12243388
40Circadian rhythm_Homo sapiens_hsa047101.10182825
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10097388
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05969236
43Lysine degradation_Homo sapiens_hsa003101.02479542
44* Gastric acid secretion_Homo sapiens_hsa049711.01916852
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92606620
46Thyroid hormone synthesis_Homo sapiens_hsa049180.88896336
47Glycerolipid metabolism_Homo sapiens_hsa005610.86388733
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85432938
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84259747
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82456956
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81538251
52Starch and sucrose metabolism_Homo sapiens_hsa005000.81016099
53Phototransduction_Homo sapiens_hsa047440.77897311
54Thyroid cancer_Homo sapiens_hsa052160.75723295
55Complement and coagulation cascades_Homo sapiens_hsa046100.74413842
56Fatty acid elongation_Homo sapiens_hsa000620.73622848
57Histidine metabolism_Homo sapiens_hsa003400.73555114
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.71960085
59Phenylalanine metabolism_Homo sapiens_hsa003600.71511599
60Lysosome_Homo sapiens_hsa041420.69039036
61cAMP signaling pathway_Homo sapiens_hsa040240.68998527
62Chemical carcinogenesis_Homo sapiens_hsa052040.68696970
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67967450
64Renin-angiotensin system_Homo sapiens_hsa046140.66229827
65Morphine addiction_Homo sapiens_hsa050320.65936506
66Tight junction_Homo sapiens_hsa045300.65735617
67Synaptic vesicle cycle_Homo sapiens_hsa047210.65617560
68Dorso-ventral axis formation_Homo sapiens_hsa043200.65380775
69Serotonergic synapse_Homo sapiens_hsa047260.65106188
70Biosynthesis of amino acids_Homo sapiens_hsa012300.63336632
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61852990
72Fructose and mannose metabolism_Homo sapiens_hsa000510.59962412
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58017798
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57741269
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55682924
76Oxidative phosphorylation_Homo sapiens_hsa001900.55572801
77Ether lipid metabolism_Homo sapiens_hsa005650.55346418
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55210397
79Cocaine addiction_Homo sapiens_hsa050300.53211045
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.51388786
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51036606
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.50596544
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.49284494
84Circadian entrainment_Homo sapiens_hsa047130.48439326
85Selenocompound metabolism_Homo sapiens_hsa004500.47048502
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46709023
87Arachidonic acid metabolism_Homo sapiens_hsa005900.46377512
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44756000
89Steroid biosynthesis_Homo sapiens_hsa001000.43827367
90Retinol metabolism_Homo sapiens_hsa008300.43078679
91Fatty acid biosynthesis_Homo sapiens_hsa000610.42412133
92Metabolic pathways_Homo sapiens_hsa011000.41120406
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40265492
94Focal adhesion_Homo sapiens_hsa045100.39877348
95Linoleic acid metabolism_Homo sapiens_hsa005910.39833440
96Salivary secretion_Homo sapiens_hsa049700.38682258
97Dopaminergic synapse_Homo sapiens_hsa047280.37619693
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37088203
99Choline metabolism in cancer_Homo sapiens_hsa052310.37010135
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.34945191
101Amphetamine addiction_Homo sapiens_hsa050310.34378956
102Hippo signaling pathway_Homo sapiens_hsa043900.33731719
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32422957
104GABAergic synapse_Homo sapiens_hsa047270.31494100
105Vibrio cholerae infection_Homo sapiens_hsa051100.31436632
106Folate biosynthesis_Homo sapiens_hsa007900.30994214
107Sphingolipid metabolism_Homo sapiens_hsa006000.30645645
108Pentose phosphate pathway_Homo sapiens_hsa000300.30397841
109Tyrosine metabolism_Homo sapiens_hsa003500.29955384
110Pancreatic secretion_Homo sapiens_hsa049720.28001744
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27316466
112Cardiac muscle contraction_Homo sapiens_hsa042600.27170974
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.25658993
114Regulation of autophagy_Homo sapiens_hsa041400.25516602
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25001541
116Nicotine addiction_Homo sapiens_hsa050330.24760247
117ABC transporters_Homo sapiens_hsa020100.23728965
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.22196805
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22089422
120Insulin secretion_Homo sapiens_hsa049110.21933812
121Rheumatoid arthritis_Homo sapiens_hsa053230.18514961
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15547170
123Sulfur relay system_Homo sapiens_hsa041220.14747328
124Parkinsons disease_Homo sapiens_hsa050120.13027053
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12205965
126Inositol phosphate metabolism_Homo sapiens_hsa005620.10666892
127Taste transduction_Homo sapiens_hsa047420.10229353
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08524352
129Hedgehog signaling pathway_Homo sapiens_hsa043400.07973000
130Glutamatergic synapse_Homo sapiens_hsa047240.03258450
131Renin secretion_Homo sapiens_hsa049240.03229253

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