KCNJ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)4.82658450
2parturition (GO:0007567)4.61249122
3behavioral response to nicotine (GO:0035095)4.45418935
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.44454051
5DNA deamination (GO:0045006)4.28856487
6sulfation (GO:0051923)4.02160235
7activated T cell proliferation (GO:0050798)3.96841966
8sarcoplasmic reticulum calcium ion transport (GO:0070296)3.96226446
9regulation of cell communication by electrical coupling (GO:0010649)3.86098588
10regulation of germinal center formation (GO:0002634)3.83096205
11myofibril assembly (GO:0030239)3.80001653
12* regulation of skeletal muscle contraction (GO:0014819)3.79813038
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.78864699
14regulation of DNA endoreduplication (GO:0032875)3.78145021
15cellular response to exogenous dsRNA (GO:0071360)3.77654733
16regulation of sarcomere organization (GO:0060297)3.63292188
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57970167
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.57970167
19NADH dehydrogenase complex assembly (GO:0010257)3.57970167
20regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.56264357
21cardiac myofibril assembly (GO:0055003)3.52684829
22negative regulation of systemic arterial blood pressure (GO:0003085)3.51588408
23positive regulation of synapse maturation (GO:0090129)3.47818308
24muscle filament sliding (GO:0030049)3.44116504
25actin-myosin filament sliding (GO:0033275)3.44116504
26regulation of mesoderm development (GO:2000380)3.43397844
27response to xenobiotic stimulus (GO:0009410)3.42971461
28cell proliferation in forebrain (GO:0021846)3.37960646
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.29306732
30regulation of synapse maturation (GO:0090128)3.29256626
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.28143707
32sarcomere organization (GO:0045214)3.26758067
33cellular response to electrical stimulus (GO:0071257)3.26549565
34cellular anion homeostasis (GO:0030002)3.26506848
35positive regulation of cellular amide metabolic process (GO:0034250)3.23037606
36response to electrical stimulus (GO:0051602)3.22151807
37regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.22035704
38positive regulation by symbiont of host defense response (GO:0052509)3.19870155
39modulation by symbiont of host defense response (GO:0052031)3.19870155
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19870155
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19870155
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.19870155
43modulation by symbiont of host immune response (GO:0052553)3.19870155
44water-soluble vitamin biosynthetic process (GO:0042364)3.19423641
45regulation of relaxation of muscle (GO:1901077)3.18647383
46DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16369949
47cardiovascular system development (GO:0072358)3.15418515
48vitamin catabolic process (GO:0009111)3.12361202
49fat-soluble vitamin catabolic process (GO:0042363)3.12361202
50protein complex biogenesis (GO:0070271)3.12086866
51ovulation cycle (GO:0042698)3.07956609
52regulation of actin filament-based movement (GO:1903115)3.04011950
53plasma membrane repair (GO:0001778)3.04011479
54regulation of glomerulus development (GO:0090192)2.96150068
55actin-mediated cell contraction (GO:0070252)2.95770712
56T cell mediated immunity (GO:0002456)2.94480571
57positive regulation of defense response to virus by host (GO:0002230)2.92050649
58dentate gyrus development (GO:0021542)2.90283402
59* membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83530656
60retinal ganglion cell axon guidance (GO:0031290)2.81736672
61negative regulation of appetite (GO:0032099)2.79704762
62negative regulation of response to food (GO:0032096)2.79704762
63positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75647409
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73347731
65skeletal muscle contraction (GO:0003009)2.72384877
66mitochondrial respiratory chain complex assembly (GO:0033108)2.72355091
67macrophage activation involved in immune response (GO:0002281)2.71910831
68cellular response to ATP (GO:0071318)2.71359959
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67665750
70cardiac muscle hypertrophy (GO:0003300)2.67372346
71actomyosin structure organization (GO:0031032)2.66833711
72gamma-aminobutyric acid transport (GO:0015812)2.66044772
733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.65408028
74purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.65408028
75negative regulation of protein localization to cell surface (GO:2000009)2.64818766
76serotonin metabolic process (GO:0042428)2.64639034
77skeletal muscle adaptation (GO:0043501)2.64600702
78DNA damage response, signal transduction resulting in transcription (GO:0042772)2.63709397
79* regulation of striated muscle contraction (GO:0006942)2.63643935
80negative regulation of mast cell activation (GO:0033004)2.63252317
81actin filament-based movement (GO:0030048)2.63119761
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.62745445
83interkinetic nuclear migration (GO:0022027)2.62647089
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61936082
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.61571658
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.60327953
87striated muscle contraction (GO:0006941)2.59240717
88positive regulation of cardiac muscle cell differentiation (GO:2000727)2.56986109
89positive regulation of cAMP-mediated signaling (GO:0043950)2.56586728
90neutrophil activation involved in immune response (GO:0002283)2.56391194
91cardiac muscle contraction (GO:0060048)2.55513228
92striated muscle hypertrophy (GO:0014897)2.55161319
93* relaxation of cardiac muscle (GO:0055119)2.54995414
94endoderm formation (GO:0001706)2.54879428
95regulation of synapse structural plasticity (GO:0051823)2.54699360
96alkaloid metabolic process (GO:0009820)2.54155215
97regulation of cell proliferation involved in kidney development (GO:1901722)2.54075808
98microglial cell activation (GO:0001774)2.51709170
99muscle hypertrophy (GO:0014896)2.50421741
100* regulation of membrane repolarization (GO:0060306)2.50272545
101regulation of calcium ion transmembrane transport (GO:1903169)2.49463564
102regulation of calcium ion transmembrane transporter activity (GO:1901019)2.49463564
103somite development (GO:0061053)2.48613134
104interferon-gamma production (GO:0032609)2.48308998
105adaptation of signaling pathway (GO:0023058)2.47785593
106neutrophil mediated immunity (GO:0002446)2.47641438
107positive regulation of meiosis (GO:0045836)2.47377357
108regulation of regulatory T cell differentiation (GO:0045589)2.46870430
109regulation of cardiac muscle cell contraction (GO:0086004)2.46728416
110protein polyglutamylation (GO:0018095)2.46259169
111detection of light stimulus involved in sensory perception (GO:0050962)2.46164866
112detection of light stimulus involved in visual perception (GO:0050908)2.46164866
113negative regulation of fatty acid transport (GO:2000192)2.46003142
114epithelial cell fate commitment (GO:0072148)2.44325196
115flavonoid metabolic process (GO:0009812)2.43898551
116indolalkylamine metabolic process (GO:0006586)2.43242185
117pyrimidine ribonucleoside catabolic process (GO:0046133)2.41917182
118response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.41810451
119regulation of cardiac muscle contraction (GO:0055117)2.41643018
120response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41481983
121response to host immune response (GO:0052572)2.41481983
122negative regulation of ERK1 and ERK2 cascade (GO:0070373)2.41314607
123response to peptidoglycan (GO:0032494)2.40423463
124positive regulation of cation channel activity (GO:2001259)2.40393061
125response to inactivity (GO:0014854)2.39982199
126neuronal action potential (GO:0019228)2.39831627
127regulation of interferon-beta biosynthetic process (GO:0045357)2.38820735
128chemical homeostasis within a tissue (GO:0048875)2.38598428
129primary amino compound metabolic process (GO:1901160)2.38077955
130prostate gland growth (GO:0060736)2.38046724
131monocyte chemotaxis (GO:0002548)2.37613488
132negative regulation of Rho protein signal transduction (GO:0035024)2.36942483
133* cardiac conduction (GO:0061337)2.36705419
134L-amino acid import (GO:0043092)2.35129189
135dendritic spine morphogenesis (GO:0060997)2.35017219
136regulation of potassium ion transmembrane transporter activity (GO:1901016)2.31120757
137establishment of protein localization to mitochondrial membrane (GO:0090151)2.31050601
138positive regulation of meiotic cell cycle (GO:0051446)2.30371909
139detection of calcium ion (GO:0005513)2.28507916
140regulation of non-canonical Wnt signaling pathway (GO:2000050)2.27429393
141surfactant homeostasis (GO:0043129)2.26971156
142striated muscle atrophy (GO:0014891)2.26557805
143* regulation of potassium ion transmembrane transport (GO:1901379)2.25924650
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.25610544
145response to caffeine (GO:0031000)2.25521150
146peptidyl-tyrosine autophosphorylation (GO:0038083)2.25002463
147cAMP catabolic process (GO:0006198)2.24922709
148regulation of sequestering of triglyceride (GO:0010889)2.24724579
149regulation of cation channel activity (GO:2001257)2.24412578
150synaptic transmission, cholinergic (GO:0007271)2.24006094
151response to host defenses (GO:0052200)2.23692023
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.23692023
153response to host (GO:0075136)2.23692023
154positive regulation of interferon-alpha production (GO:0032727)2.23538314
155cytidine metabolic process (GO:0046087)2.22773077
156cytidine catabolic process (GO:0006216)2.22773077
157cytidine deamination (GO:0009972)2.22773077
158regulation of interferon-alpha production (GO:0032647)2.22724497
159segment specification (GO:0007379)2.22172142
160regulation of interleukin-12 biosynthetic process (GO:0045075)2.20555103
161glandular epithelial cell differentiation (GO:0002067)2.18985386
162indole-containing compound catabolic process (GO:0042436)2.17962851
163indolalkylamine catabolic process (GO:0046218)2.17962851
164tryptophan catabolic process (GO:0006569)2.17962851
165pharyngeal system development (GO:0060037)2.17696611
166striated muscle adaptation (GO:0014888)2.17044439
167muscle adaptation (GO:0043500)2.16924908
168striatum development (GO:0021756)2.16203212
169regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.16029053
170negative regulation of sodium ion transport (GO:0010766)2.15681353
171macrophage activation (GO:0042116)2.15567667
172positive regulation of heat generation (GO:0031652)2.15508790
173regulation of action potential (GO:0098900)2.15319169
174heart trabecula formation (GO:0060347)2.14706155
175replicative senescence (GO:0090399)2.14215390
176positive regulation of macrophage cytokine production (GO:0060907)2.14020875
177regulation of heat generation (GO:0031650)2.13813561
178cytokine secretion (GO:0050663)2.13590952
179substrate-dependent cell migration (GO:0006929)2.13546472
180spinal cord motor neuron differentiation (GO:0021522)2.13255844
181regulation of type B pancreatic cell apoptotic process (GO:2000674)2.12672512
182regulation of cardiac muscle cell differentiation (GO:2000725)2.10690953
183positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.10660121
184ganglion development (GO:0061548)2.10485838
185cyclic nucleotide catabolic process (GO:0009214)2.09206207
186muscle atrophy (GO:0014889)2.08545804
187import into cell (GO:0098657)2.06719886
188negative regulation of cytosolic calcium ion concentration (GO:0051481)2.06258347
189adrenergic receptor signaling pathway (GO:0071875)2.05888588
190G-protein coupled receptor internalization (GO:0002031)2.05079797
191cell communication involved in cardiac conduction (GO:0086065)2.04962419
192regulation of p38MAPK cascade (GO:1900744)2.03841820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.93292128
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.58761672
3GBX2_23144817_ChIP-Seq_PC3_Human2.61614069
4VDR_22108803_ChIP-Seq_LS180_Human2.56156769
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45052230
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.31085771
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01935217
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.01531219
9* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96790489
10EP300_21415370_ChIP-Seq_HL-1_Mouse1.95800998
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95796706
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88130490
13EZH2_22144423_ChIP-Seq_EOC_Human1.84441196
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81662154
15ZNF274_21170338_ChIP-Seq_K562_Hela1.78836823
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.75925278
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74947641
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.73601894
19IRF1_19129219_ChIP-ChIP_H3396_Human1.72780167
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71328855
21DROSHA_22980978_ChIP-Seq_HELA_Human1.70140589
22AR_21572438_ChIP-Seq_LNCaP_Human1.67457028
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64125875
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64125875
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63059688
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61317236
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55231862
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55069372
29TP53_16413492_ChIP-PET_HCT116_Human1.54381673
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.53475269
31* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53142473
32* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53142473
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52709642
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52148851
35RNF2_27304074_Chip-Seq_NSC_Mouse1.51653651
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50366638
37REST_21632747_ChIP-Seq_MESCs_Mouse1.48554201
38* EWS_26573619_Chip-Seq_HEK293_Human1.47882629
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47255196
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.46943442
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46783234
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46477243
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45867911
44AHR_22903824_ChIP-Seq_MCF-7_Human1.43891959
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.42114459
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40670661
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40642962
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.39827568
49BCAT_22108803_ChIP-Seq_LS180_Human1.39403815
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.39364272
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.39205780
52* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39110421
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39005042
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38141649
55IGF1R_20145208_ChIP-Seq_DFB_Human1.36120893
56* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35305665
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.35152908
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.32217720
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.31457528
60* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31350558
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30299338
62VDR_24787735_ChIP-Seq_THP-1_Human1.30054427
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29365137
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29365137
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.29347435
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29125205
67FUS_26573619_Chip-Seq_HEK293_Human1.27928796
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27794938
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27269753
70TP53_18474530_ChIP-ChIP_U2OS_Human1.27164551
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25181074
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24904808
73SMAD4_21799915_ChIP-Seq_A2780_Human1.23891873
74* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23612507
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.23117449
76* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23074234
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22843072
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22411477
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21450844
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.20395829
81CJUN_26792858_Chip-Seq_BT549_Human1.19857203
82* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17834409
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17611887
84CBP_20019798_ChIP-Seq_JUKART_Human1.17611887
85* PRDM14_20953172_ChIP-Seq_ESCs_Human1.16858767
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16758085
87* TAF15_26573619_Chip-Seq_HEK293_Human1.15242412
88* TCF4_23295773_ChIP-Seq_U87_Human1.15163746
89* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13563930
90ER_23166858_ChIP-Seq_MCF-7_Human1.12444757
91* P300_19829295_ChIP-Seq_ESCs_Human1.12405936
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.12382473
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.12382473
94* RXR_22108803_ChIP-Seq_LS180_Human1.12115544
95* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11637707
96* FLI1_21867929_ChIP-Seq_TH2_Mouse1.10404126
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10219416
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.07820919
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.07439810
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.06969729
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05646367
102* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05534058
103SOX2_19829295_ChIP-Seq_ESCs_Human1.04608007
104NANOG_19829295_ChIP-Seq_ESCs_Human1.04608007
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.03128181
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02492246
107* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02281148
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02180273
109JUN_21703547_ChIP-Seq_K562_Human1.01265845
110STAT3_23295773_ChIP-Seq_U87_Human1.00409679
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00162885
112* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99883977
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99745023
114* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99491665
115SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98908056
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98827315
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98505958
118* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98488598
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98091163
120* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97423796
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.97036524
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.96518754
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.96517895
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96512783
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95768880
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95414439
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94490028
128* AR_25329375_ChIP-Seq_VCAP_Human0.94430772
129FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93918647
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.93918647
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93849984
132* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93788426
133* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93672392
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.93296954
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.93211589
136* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92733172
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92588142
138* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90628275
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90585538
140* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89567928
141RUNX_20019798_ChIP-Seq_JUKART_Human0.88317888
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.87901970
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87386383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy3.38853633
2MP0002837_dystrophic_cardiac_calcinosis3.25378720
3MP0003646_muscle_fatigue3.21240603
4MP0003724_increased_susceptibility_to3.18504114
5MP0004885_abnormal_endolymph3.07249065
6MP0000749_muscle_degeneration3.01444302
7MP0004084_abnormal_cardiac_muscle2.98816200
8MP0004036_abnormal_muscle_relaxation2.85372297
9MP0004215_abnormal_myocardial_fiber2.85073035
10MP0008877_abnormal_DNA_methylation2.81177781
11MP0004484_altered_response_of2.51682629
12MP0003690_abnormal_glial_cell2.44971809
13MP0004130_abnormal_muscle_cell2.39472890
14MP0004145_abnormal_muscle_electrophysio2.38097074
15MP0002972_abnormal_cardiac_muscle2.37452188
16MP0005620_abnormal_muscle_contractility2.27024243
17MP0005646_abnormal_pituitary_gland2.24007137
18MP0004087_abnormal_muscle_fiber2.15997666
19MP0005167_abnormal_blood-brain_barrier2.15077029
20MP0002160_abnormal_reproductive_system2.12936490
21MP0004510_myositis2.11862039
22MP0005330_cardiomyopathy2.06851559
23MP0004859_abnormal_synaptic_plasticity2.03262455
24MP0002638_abnormal_pupillary_reflex2.01288756
25MP0002106_abnormal_muscle_physiology1.99269681
26MP0005389_reproductive_system_phenotype1.98829249
27MP0002138_abnormal_hepatobiliary_system1.96286058
28MP0003787_abnormal_imprinting1.95072559
29MP0003828_pulmonary_edema1.94660195
30MP0000569_abnormal_digit_pigmentation1.92963755
31MP0003283_abnormal_digestive_organ1.92770631
32MP0003011_delayed_dark_adaptation1.92323737
33MP0001485_abnormal_pinna_reflex1.92189575
34MP0005671_abnormal_response_to1.84539099
35MP0002332_abnormal_exercise_endurance1.77771501
36MP0006292_abnormal_olfactory_placode1.76921456
37MP0004142_abnormal_muscle_tone1.76279752
38MP0002822_catalepsy1.76251473
39MP0002272_abnormal_nervous_system1.76002584
40MP0005058_abnormal_lysosome_morphology1.75551118
41MP0006072_abnormal_retinal_apoptosis1.74247158
42MP0005171_absent_coat_pigmentation1.73441878
43MP0005369_muscle_phenotype1.69814267
44MP0006082_CNS_inflammation1.68794831
45MP0010630_abnormal_cardiac_muscle1.68107910
46MP0000920_abnormal_myelination1.68013448
47MP0001544_abnormal_cardiovascular_syste1.67371811
48MP0005385_cardiovascular_system_phenoty1.67371811
49MP0000750_abnormal_muscle_regeneration1.66300503
50MP0003303_peritoneal_inflammation1.65669795
51MP0003950_abnormal_plasma_membrane1.64469120
52MP0006138_congestive_heart_failure1.58967335
53MP0003137_abnormal_impulse_conducting1.57363243
54MP0002876_abnormal_thyroid_physiology1.56738454
55MP0003879_abnormal_hair_cell1.55595721
56MP0000631_abnormal_neuroendocrine_gland1.55094524
57MP0008775_abnormal_heart_ventricle1.52158468
58MP0004085_abnormal_heartbeat1.51288750
59MP0000759_abnormal_skeletal_muscle1.51110403
60MP0005551_abnormal_eye_electrophysiolog1.49837143
61MP0002163_abnormal_gland_morphology1.49646115
62MP0001968_abnormal_touch/_nociception1.48856907
63MP0003075_altered_response_to1.47978222
64MP0000747_muscle_weakness1.41221596
65MP0009764_decreased_sensitivity_to1.40983911
66MP0003195_calcinosis1.35289693
67MP0000049_abnormal_middle_ear1.34956119
68MP0000685_abnormal_immune_system1.32496817
69MP0000343_altered_response_to1.31574876
70MP0005174_abnormal_tail_pigmentation1.29926213
71MP0001919_abnormal_reproductive_system1.28814586
72MP0002419_abnormal_innate_immunity1.26994258
73MP0004019_abnormal_vitamin_homeostasis1.26516878
74MP0001486_abnormal_startle_reflex1.26353673
75MP0004742_abnormal_vestibular_system1.26044204
76MP0001958_emphysema1.25761326
77MP0002735_abnormal_chemical_nociception1.25731404
78MP0005379_endocrine/exocrine_gland_phen1.25292738
79MP0001765_abnormal_ion_homeostasis1.25043793
80MP0001879_abnormal_lymphatic_vessel1.25018541
81MP0001986_abnormal_taste_sensitivity1.22714206
82MP0004133_heterotaxia1.22482639
83MP0002653_abnormal_ependyma_morphology1.22260459
84MP0003172_abnormal_lysosome_physiology1.22066714
85MP0001851_eye_inflammation1.21233245
86MP0002102_abnormal_ear_morphology1.20683523
87MP0005084_abnormal_gallbladder_morpholo1.18765619
88MP0008004_abnormal_stomach_pH1.18603710
89MP0009785_altered_susceptibility_to1.18600894
90MP0003633_abnormal_nervous_system1.17946579
91MP0004270_analgesia1.17863438
92MP0003183_abnormal_peptide_metabolism1.17148587
93MP0005409_darkened_coat_color1.16943460
94MP0000733_abnormal_muscle_development1.16614311
95MP0001800_abnormal_humoral_immune1.16489168
96MP0000230_abnormal_systemic_arterial1.16263211
97MP0003300_gastrointestinal_ulcer1.15996867
98MP0001970_abnormal_pain_threshold1.15093074
99MP0009780_abnormal_chondrocyte_physiolo1.14806328
100MP0005253_abnormal_eye_physiology1.14269225
101MP0002733_abnormal_thermal_nociception1.12569587
102MP0002090_abnormal_vision1.12478011
103MP0008872_abnormal_physiological_respon1.12118469
104MP0004134_abnormal_chest_morphology1.10445020
105MP0009745_abnormal_behavioral_response1.08669824
106MP0005166_decreased_susceptibility_to1.06985435
107MP0003880_abnormal_central_pattern1.05160025
108MP0003045_fibrosis1.04467000
109MP0002064_seizures1.04171527
110MP0004147_increased_porphyrin_level1.03905934
111MP0001905_abnormal_dopamine_level1.02505098
112MP0002133_abnormal_respiratory_system1.02205901
113MP0005388_respiratory_system_phenotype1.02205901
114MP0005165_increased_susceptibility_to1.01798685
115MP0002998_abnormal_bone_remodeling1.01146467
116MP0002928_abnormal_bile_duct1.00161832
117MP0003121_genomic_imprinting1.00061840
118MP0003436_decreased_susceptibility_to0.99018454
119MP0009379_abnormal_foot_pigmentation0.98156644
120MP0003191_abnormal_cellular_cholesterol0.97873854
121MP0002572_abnormal_emotion/affect_behav0.97014206
122MP0001790_abnormal_immune_system0.96833486
123MP0005387_immune_system_phenotype0.96833486
124MP0001188_hyperpigmentation0.96337187
125MP0003635_abnormal_synaptic_transmissio0.94723798
126MP0001835_abnormal_antigen_presentation0.94325942
127MP0002736_abnormal_nociception_after0.93369388
128MP0001542_abnormal_bone_strength0.93320439
129MP0009046_muscle_twitch0.93176116
130MP0008438_abnormal_cutaneous_collagen0.92610276
131MP0002269_muscular_atrophy0.90248706
132MP0002067_abnormal_sensory_capabilities0.90205820
133MP0000026_abnormal_inner_ear0.90084837
134MP0001533_abnormal_skeleton_physiology0.89958064
135MP0001984_abnormal_olfaction0.89931245
136MP0002108_abnormal_muscle_morphology0.89259826
137MP0009765_abnormal_xenobiotic_induced0.88935746
138MP0009250_abnormal_appendicular_skeleto0.87849234
139MP0006276_abnormal_autonomic_nervous0.86829084
140MP0002938_white_spotting0.86300060
141MP0002723_abnormal_immune_serum0.84105941
142MP0001177_atelectasis0.84075733
143MP0003566_abnormal_cell_adhesion0.83975284
144MP0003634_abnormal_glial_cell0.83929917
145MP0002063_abnormal_learning/memory/cond0.83492891
146MP0003279_aneurysm0.83252560
147MP0005423_abnormal_somatic_nervous0.81965960
148MP0000767_abnormal_smooth_muscle0.81107813
149MP0010678_abnormal_skin_adnexa0.80523849
150MP0005000_abnormal_immune_tolerance0.80428308
151MP0001502_abnormal_circadian_rhythm0.80189382
152MP0002148_abnormal_hypersensitivity_rea0.79957118
153MP0010368_abnormal_lymphatic_system0.79760727
154MP0002452_abnormal_antigen_presenting0.79739044
155MP0005195_abnormal_posterior_eye0.79612546
156MP0005386_behavior/neurological_phenoty0.78092847
157MP0004924_abnormal_behavior0.78092847
158MP0001963_abnormal_hearing_physiology0.77942671
159MP0003221_abnormal_cardiomyocyte_apopto0.77922395
160MP0000383_abnormal_hair_follicle0.76814202
161MP0002557_abnormal_social/conspecific_i0.76645030
162MP0002734_abnormal_mechanical_nocicepti0.76476501
163MP0001501_abnormal_sleep_pattern0.76268527
164MP0003938_abnormal_ear_development0.75872500
165MP0000470_abnormal_stomach_morphology0.74473594
166MP0004782_abnormal_surfactant_physiolog0.74347669
167MP0002277_abnormal_respiratory_mucosa0.73025381
168MP0001440_abnormal_grooming_behavior0.72593004
169MP0001663_abnormal_digestive_system0.72531190
170MP0004185_abnormal_adipocyte_glucose0.71670363
171MP0003631_nervous_system_phenotype0.71662202
172MP0009278_abnormal_bone_marrow0.70966384
173MP0004233_abnormal_muscle_weight0.69320745
174MP0001299_abnormal_eye_distance/0.69236522
175MP0005666_abnormal_adipose_tissue0.66596515
176MP0005623_abnormal_meninges_morphology0.63903953

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)5.73746788
2Exercise-induced myalgia (HP:0003738)5.31297684
3Muscle hypertrophy of the lower extremities (HP:0008968)5.07224414
4Sudden death (HP:0001699)5.04530809
5Calf muscle hypertrophy (HP:0008981)4.83794245
6Muscle fiber splitting (HP:0003555)4.36601311
7Muscle fiber inclusion bodies (HP:0100299)4.28395091
8* Atrial fibrillation (HP:0005110)4.21256253
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.15287909
10Abnormality of the calf musculature (HP:0001430)3.91424110
11* Primary atrial arrhythmia (HP:0001692)3.87725663
12Hyporeflexia of lower limbs (HP:0002600)3.87449086
13EMG: myopathic abnormalities (HP:0003458)3.82788953
14Nemaline bodies (HP:0003798)3.77807431
15Ventricular tachycardia (HP:0004756)3.69184773
16Osteomalacia (HP:0002749)3.62807632
17* Supraventricular tachycardia (HP:0004755)3.58051726
18Decreased circulating renin level (HP:0003351)3.52004352
19* Supraventricular arrhythmia (HP:0005115)3.50631670
20Axonal loss (HP:0003447)3.49305024
21Recurrent abscess formation (HP:0002722)3.45112954
22Type 1 muscle fiber predominance (HP:0003803)3.39924815
23Difficulty running (HP:0009046)3.39221729
24Prolonged QT interval (HP:0001657)3.38171008
25Pancreatic cysts (HP:0001737)3.37707324
26Subaortic stenosis (HP:0001682)3.35995640
27Abnormality of the left ventricular outflow tract (HP:0011103)3.35995640
28Eczematoid dermatitis (HP:0000976)3.33568065
29Increased cerebral lipofuscin (HP:0011813)3.32774431
30Conjunctival hamartoma (HP:0100780)3.27437497
31Nephronophthisis (HP:0000090)3.21387807
32Congenital, generalized hypertrichosis (HP:0004540)3.21339576
33* Syncope (HP:0001279)3.19833026
34Congenital stationary night blindness (HP:0007642)3.17779293
35Progressive cerebellar ataxia (HP:0002073)3.12220000
36Increased neuronal autofluorescent lipopigment (HP:0002074)3.11376526
37Pancreatic fibrosis (HP:0100732)3.11257077
38Clumsiness (HP:0002312)3.08900788
39Distal lower limb amyotrophy (HP:0008944)3.07695243
40Bundle branch block (HP:0011710)3.05947878
41Abolished electroretinogram (ERG) (HP:0000550)3.03937564
42Increased connective tissue (HP:0009025)3.02882632
43Abnormality of the phalanges of the 2nd finger (HP:0009541)3.00920903
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.98882703
45True hermaphroditism (HP:0010459)2.97986633
46Short femoral neck (HP:0100864)2.97810161
47Genetic anticipation (HP:0003743)2.93848474
48Abnormality of midbrain morphology (HP:0002418)2.88636178
49Molar tooth sign on MRI (HP:0002419)2.88636178
50Lipoatrophy (HP:0100578)2.87452315
51Recurrent bacterial skin infections (HP:0005406)2.84257401
52Thick nail (HP:0001805)2.84155313
53Asplenia (HP:0001746)2.81590737
54Abnormality of the renal medulla (HP:0100957)2.77663714
55Lower limb amyotrophy (HP:0007210)2.75829556
56Asymmetric septal hypertrophy (HP:0001670)2.74793442
57Short hallux (HP:0010109)2.73641452
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.72359356
59Dilated cardiomyopathy (HP:0001644)2.68145268
60Heart block (HP:0012722)2.66932160
61Anomalous pulmonary venous return (HP:0010772)2.64626816
62Right ventricular cardiomyopathy (HP:0011663)2.64492486
63Abnormality of the middle phalanges of the toes (HP:0010183)2.63483682
64Furrowed tongue (HP:0000221)2.62966159
65Myotonia (HP:0002486)2.62068334
66Myoglobinuria (HP:0002913)2.61402575
67Aplasia/Hypoplasia of the hallux (HP:0008362)2.61220911
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.61194641
69Increased variability in muscle fiber diameter (HP:0003557)2.57067443
70Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.56142134
71Abnormality of skeletal muscle fiber size (HP:0012084)2.55902876
72Abnormal atrioventricular conduction (HP:0005150)2.54002652
73Abnormality of the phalanges of the 5th finger (HP:0004213)2.52449538
74Abnormal rod and cone electroretinograms (HP:0008323)2.52319741
75Adactyly (HP:0009776)2.52128185
76Megalencephaly (HP:0001355)2.51391350
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50649674
78Abnormality of the pulmonary veins (HP:0011718)2.50381663
79Abnormality of the renal cortex (HP:0011035)2.47634608
80Hemiplegia (HP:0002301)2.46333546
81Muscle stiffness (HP:0003552)2.45893700
82Short 1st metacarpal (HP:0010034)2.44007670
83Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.44007670
84Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.40556063
85Prostate neoplasm (HP:0100787)2.40045230
86Hematochezia (HP:0002573)2.39824461
87Frequent falls (HP:0002359)2.38651511
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.38651061
89Absent/shortened dynein arms (HP:0200106)2.38651061
90Congenital sensorineural hearing impairment (HP:0008527)2.36867696
91Hamartoma of the eye (HP:0010568)2.36826425
92Focal motor seizures (HP:0011153)2.36218960
93Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35637053
94Distal arthrogryposis (HP:0005684)2.31889124
95Fibular aplasia (HP:0002990)2.31722193
96Abnormality of renal resorption (HP:0011038)2.31639336
97Hypoplasia of the uterus (HP:0000013)2.31442847
98Round ear (HP:0100830)2.30485409
99Abnormal drinking behavior (HP:0030082)2.28945969
100Polydipsia (HP:0001959)2.28945969
101Hypoplasia of the ulna (HP:0003022)2.28207869
102Decreased central vision (HP:0007663)2.27862022
103* Ventricular arrhythmia (HP:0004308)2.27714192
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.26330041
105Disinhibition (HP:0000734)2.25642127
106Abnormality of macrophages (HP:0004311)2.25570194
107Mesomelia (HP:0003027)2.24488161
108Symphalangism affecting the phalanges of the hand (HP:0009773)2.24163388
109Stomach cancer (HP:0012126)2.23047358
110Metabolic alkalosis (HP:0200114)2.22787882
111Pendular nystagmus (HP:0012043)2.22098440
112Atrioventricular block (HP:0001678)2.21905677
113Distal lower limb muscle weakness (HP:0009053)2.21365793
114Recurrent gram-negative bacterial infections (HP:0005420)2.19908956
115* Abnormal EKG (HP:0003115)2.19729352
116Facial diplegia (HP:0001349)2.19410631
117Hypoplastic ischia (HP:0003175)2.18786011
118Stenosis of the external auditory canal (HP:0000402)2.15990524
119Aplasia/hypoplasia of the uterus (HP:0008684)2.11685113
120Arterial tortuosity (HP:0005116)2.11582001
121Abnormality of the 1st metacarpal (HP:0010009)2.09885001
122Agitation (HP:0000713)2.09451208
123Hypoplasia of the iris (HP:0007676)2.08736242
124Abnormality of renal excretion (HP:0011036)2.07384782
125Abnormality of secondary sexual hair (HP:0009888)2.07247013
126Abnormality of the axillary hair (HP:0100134)2.07247013
127Short tibia (HP:0005736)2.07023696
128Gaze-evoked nystagmus (HP:0000640)2.06490876
129Short 4th metacarpal (HP:0010044)2.04190509
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04190509
131Retrobulbar optic neuritis (HP:0100654)2.04178672
132Optic neuritis (HP:0100653)2.04178672
133Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.03870758
134Oral leukoplakia (HP:0002745)2.03749429
135Left ventricular hypertrophy (HP:0001712)2.01573151
136Neck muscle weakness (HP:0000467)2.01458937
137Medial flaring of the eyebrow (HP:0010747)2.00942826
138Abnormality of the renal collecting system (HP:0004742)2.00008783
139Male pseudohermaphroditism (HP:0000037)1.99570582
140Abnormal respiratory motile cilium morphology (HP:0005938)1.99228377
141Abnormal respiratory epithelium morphology (HP:0012253)1.99228377
142* Scapular winging (HP:0003691)1.98615733
143Foot dorsiflexor weakness (HP:0009027)1.97906063
144Aplasia/Hypoplasia of the fibula (HP:0006492)1.97802805
145Bone cyst (HP:0012062)1.97399003
146Goiter (HP:0000853)1.95878866
147Ventricular fibrillation (HP:0001663)1.94045856
148Abnormality of glycolipid metabolism (HP:0010969)1.93775520
149Abnormality of liposaccharide metabolism (HP:0010968)1.93775520
150Abnormality of glycosphingolipid metabolism (HP:0004343)1.93775520
151Bony spicule pigmentary retinopathy (HP:0007737)1.93146169
152Abnormality of the nasal septum (HP:0000419)1.90832104
153Gowers sign (HP:0003391)1.89145180
154Abnormality of DNA repair (HP:0003254)1.88673221
155Mediastinal lymphadenopathy (HP:0100721)1.88071179
156Methylmalonic acidemia (HP:0002912)1.87944045
157Inappropriate behavior (HP:0000719)1.87927237
158Attenuation of retinal blood vessels (HP:0007843)1.87122707
159Abnormality of renin-angiotensin system (HP:0000847)1.87019135
160Systemic lupus erythematosus (HP:0002725)1.86521480
161Chronic hepatic failure (HP:0100626)1.86487841
162Abnormality of the ischium (HP:0003174)1.86201807
163Aplasia/hypoplasia of the femur (HP:0005613)1.85275797
164Vascular calcification (HP:0004934)1.85195553
165Abnormality of the foot musculature (HP:0001436)1.84707674
166Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84518046
167Cystic liver disease (HP:0006706)1.84078863
168Muscular dystrophy (HP:0003560)1.84063905
169Gingivitis (HP:0000230)1.83601615
1703-Methylglutaconic aciduria (HP:0003535)1.83549911
171Hyperkalemia (HP:0002153)1.82622112
172Cerebral aneurysm (HP:0004944)1.81703520
173Abnormal ciliary motility (HP:0012262)1.80802054
174Radial bowing (HP:0002986)1.80544707
175Vascular tortuosity (HP:0004948)1.80513640
176Abnormality of the right ventricle (HP:0001707)1.80242922
177Limb dystonia (HP:0002451)1.79407166
178Sudden cardiac death (HP:0001645)1.79194673
179Polyuria (HP:0000103)1.76555278
180Neurofibrillary tangles (HP:0002185)1.75435955
181Tubular atrophy (HP:0000092)1.75368877
182Centrally nucleated skeletal muscle fibers (HP:0003687)1.75047514
183Onion bulb formation (HP:0003383)1.74847397
184IgG deficiency (HP:0004315)1.74784299
185Renal cortical cysts (HP:0000803)1.74495328
186Degeneration of the lateral corticospinal tracts (HP:0002314)1.73596806
187Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73596806
188Rhabdomyolysis (HP:0003201)1.73462019
189Difficulty climbing stairs (HP:0003551)1.72607941
190Bell-shaped thorax (HP:0001591)1.70378859
191Urinary bladder sphincter dysfunction (HP:0002839)1.68867427
192Broad-based gait (HP:0002136)1.67925952
193Rapidly progressive (HP:0003678)1.61438379
194Generalized muscle weakness (HP:0003324)1.60259332
195Progressive visual loss (HP:0000529)1.59901809
196Stomatitis (HP:0010280)1.58736674
197Febrile seizures (HP:0002373)1.57454308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.21527097
2TTN3.77362187
3OBSCN3.76295644
4TLK13.63107783
5BLK3.06576173
6TAOK32.84431898
7PHKG22.76948267
8PHKG12.76948267
9ADRBK22.58760279
10RIPK42.48599616
11TGFBR22.46204248
12EPHA42.43847649
13BMPR1B2.23947728
14GRK72.14572275
15ACVR1B2.13688535
16DMPK2.11549992
17TXK1.91443434
18PIK3CA1.80067832
19TRPM71.78903603
20AKT31.68754181
21WNK41.61223365
22EPHB11.59471674
23DAPK21.48291052
24CAMK1D1.40622752
25PDK21.37871937
26PRPF4B1.35395405
27CAMK1G1.33195155
28MAPK131.31557162
29INSRR1.29767419
30PINK11.27776133
31LMTK21.25474357
32MAPK121.25202062
33TNIK1.22394269
34PIK3CG1.21111014
35RIPK11.17947770
36IKBKB1.12661845
37MAP2K41.11076893
38PKN11.10147561
39CSK1.10147237
40CASK1.08555656
41PDPK11.06517598
42TEC1.05287984
43STK391.04988758
44BMPR21.04950225
45ADRBK11.04211671
46SYK1.03320646
47MAPK71.00962904
48RPS6KA61.00216102
49SGK30.99700526
50CAMK2D0.99388577
51SGK20.98134969
52MAP3K140.95407298
53PRKCE0.94219770
54TRIB30.94049248
55TAF10.93587130
56PRKD10.92629736
57ERBB30.92577142
58STK160.92523871
59GRK60.91357265
60WNK30.91161431
61CAMK40.89500247
62JAK10.88715385
63RPS6KA20.88284452
64PRKCH0.88223508
65GRK50.87879955
66NTRK30.87842063
67ITK0.86772737
68PDK40.84630649
69PDK30.84630649
70STK240.84054252
71STK110.83722598
72PRKD20.83470676
73SGK2230.81536508
74SGK4940.81536508
75CAMKK20.80876420
76MAP3K20.79624155
77MAP3K130.79458085
78PRKAA20.79032793
79LYN0.78311969
80FGR0.77231846
81SGK10.76641109
82OXSR10.75336567
83MAP3K40.74779207
84RPS6KC10.72652305
85RPS6KL10.72652305
86PRKCG0.72465790
87MAP3K70.71481432
88PLK20.71333875
89PDK10.71174159
90CAMK2A0.71143864
91ZAK0.70965857
92MAP2K60.70595284
93EPHA30.69413548
94CAMK10.69367855
95FGFR20.68727318
96NTRK20.66981972
97MAP2K70.66916036
98MAP4K20.62880173
99MYLK0.62307208
100FRK0.61247821
101TNK20.61099286
102NLK0.61028840
103MAPKAPK50.60982872
104WNK10.60883459
105MATK0.60788111
106BMX0.60023476
107PDGFRB0.59960092
108* PRKACA0.59557909
109FES0.58146843
110HCK0.57806852
111KIT0.57737983
112IRAK40.56780633
113IRAK10.53969482
114CDK50.53927241
115NEK90.53452242
116PIM10.52647376
117BTK0.52114528
118NUAK10.51467686
119PAK30.51310999
120ERBB20.50067906
121CAMK2B0.49906398
122IRAK30.48187611
123SIK20.48083055
124FYN0.46970676
125CAMKK10.46961610
126PRKG10.46841376
127FGFR30.46515981
128LCK0.45594924
129TBK10.45576234
130PNCK0.45477983
131CAMK2G0.45164806
132CHUK0.45161229
133EGFR0.45030250
134DYRK30.44061971
135DYRK20.43878875
136ZAP700.43504965
137KDR0.43184614
138GRK10.42206230
139MAP3K90.42204249
140MUSK0.41702570
141NME10.41364535
142PRKACG0.41259940
143PTK2B0.40403374
144PRKCQ0.39569769
145HIPK20.38700601
146CLK10.38115108
147PRKCZ0.36810202
148MARK20.35900341
149NTRK10.34944076
150YES10.32841146
151IKBKE0.32232354

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.38411684
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.25063035
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11146873
4Intestinal immune network for IgA production_Homo sapiens_hsa046721.96687623
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95308026
6Phototransduction_Homo sapiens_hsa047441.90982430
7Olfactory transduction_Homo sapiens_hsa047401.84690493
8Oxidative phosphorylation_Homo sapiens_hsa001901.81416212
9Rheumatoid arthritis_Homo sapiens_hsa053231.73769684
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69428285
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.60610800
12Linoleic acid metabolism_Homo sapiens_hsa005911.59995365
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54820575
14Sulfur metabolism_Homo sapiens_hsa009201.51844936
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42311800
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41399613
17Morphine addiction_Homo sapiens_hsa050321.39137839
18Osteoclast differentiation_Homo sapiens_hsa043801.38566074
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37470612
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36263368
21Parkinsons disease_Homo sapiens_hsa050121.30100271
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29925652
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29205814
24Cardiac muscle contraction_Homo sapiens_hsa042601.29131885
25Circadian entrainment_Homo sapiens_hsa047131.28348737
26Leishmaniasis_Homo sapiens_hsa051401.28347263
27Calcium signaling pathway_Homo sapiens_hsa040201.28337357
28Lysosome_Homo sapiens_hsa041421.27129664
29Type II diabetes mellitus_Homo sapiens_hsa049301.26572733
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24674780
31Tuberculosis_Homo sapiens_hsa051521.22957998
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22146320
33Phagosome_Homo sapiens_hsa041451.21805387
34Asthma_Homo sapiens_hsa053101.20964693
35* Oxytocin signaling pathway_Homo sapiens_hsa049211.20579733
36Alzheimers disease_Homo sapiens_hsa050101.20058899
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16249941
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16138212
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12605590
40* Renin secretion_Homo sapiens_hsa049241.12353280
41* Cholinergic synapse_Homo sapiens_hsa047251.10307665
42Malaria_Homo sapiens_hsa051441.09554095
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06544215
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06247420
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.05593817
46Allograft rejection_Homo sapiens_hsa053301.05285802
47Pertussis_Homo sapiens_hsa051331.05155044
48* Gastric acid secretion_Homo sapiens_hsa049711.05066776
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04289549
50Nitrogen metabolism_Homo sapiens_hsa009101.04019523
51Salivary secretion_Homo sapiens_hsa049701.02924341
52Type I diabetes mellitus_Homo sapiens_hsa049401.01425885
53cAMP signaling pathway_Homo sapiens_hsa040241.01280099
54Collecting duct acid secretion_Homo sapiens_hsa049660.99635874
55Chemical carcinogenesis_Homo sapiens_hsa052040.99549791
56Graft-versus-host disease_Homo sapiens_hsa053320.99192924
57Glutamatergic synapse_Homo sapiens_hsa047240.98961881
58Staphylococcus aureus infection_Homo sapiens_hsa051500.98719748
59GnRH signaling pathway_Homo sapiens_hsa049120.98063934
60Retinol metabolism_Homo sapiens_hsa008300.97960527
61GABAergic synapse_Homo sapiens_hsa047270.97602398
62Caffeine metabolism_Homo sapiens_hsa002320.96118335
63Mineral absorption_Homo sapiens_hsa049780.94672681
64Ether lipid metabolism_Homo sapiens_hsa005650.94454266
65Salmonella infection_Homo sapiens_hsa051320.94075269
66Autoimmune thyroid disease_Homo sapiens_hsa053200.93800885
67Renal cell carcinoma_Homo sapiens_hsa052110.93275736
68Chemokine signaling pathway_Homo sapiens_hsa040620.93135936
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92281695
70Systemic lupus erythematosus_Homo sapiens_hsa053220.92019485
71Amoebiasis_Homo sapiens_hsa051460.91458984
72Rap1 signaling pathway_Homo sapiens_hsa040150.90122730
73Primary immunodeficiency_Homo sapiens_hsa053400.89526631
74HIF-1 signaling pathway_Homo sapiens_hsa040660.88748618
75Regulation of autophagy_Homo sapiens_hsa041400.88519925
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87807747
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87561088
78Insulin resistance_Homo sapiens_hsa049310.87357249
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.86583802
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85811381
81African trypanosomiasis_Homo sapiens_hsa051430.84990530
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.83926425
83TNF signaling pathway_Homo sapiens_hsa046680.83569069
84Focal adhesion_Homo sapiens_hsa045100.83281957
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83153553
86Platelet activation_Homo sapiens_hsa046110.81611769
87Adherens junction_Homo sapiens_hsa045200.81502087
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80259940
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80116388
90B cell receptor signaling pathway_Homo sapiens_hsa046620.79984701
91Long-term potentiation_Homo sapiens_hsa047200.77940420
92Synaptic vesicle cycle_Homo sapiens_hsa047210.77459521
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.77126835
94Dorso-ventral axis formation_Homo sapiens_hsa043200.76614162
95Vitamin digestion and absorption_Homo sapiens_hsa049770.75951804
96Ras signaling pathway_Homo sapiens_hsa040140.75328796
97MAPK signaling pathway_Homo sapiens_hsa040100.74625932
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73569987
99Serotonergic synapse_Homo sapiens_hsa047260.73181225
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.73014247
101Glioma_Homo sapiens_hsa052140.72310348
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72156156
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70595131
104Arachidonic acid metabolism_Homo sapiens_hsa005900.70559130
105Insulin secretion_Homo sapiens_hsa049110.70459231
106Protein export_Homo sapiens_hsa030600.69516558
107Toxoplasmosis_Homo sapiens_hsa051450.69208403
108Selenocompound metabolism_Homo sapiens_hsa004500.69039653
109Legionellosis_Homo sapiens_hsa051340.68243532
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68227287
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68116722
112Amphetamine addiction_Homo sapiens_hsa050310.67765173
113VEGF signaling pathway_Homo sapiens_hsa043700.67696026
114Viral myocarditis_Homo sapiens_hsa054160.67275230
115FoxO signaling pathway_Homo sapiens_hsa040680.67161609
116Hematopoietic cell lineage_Homo sapiens_hsa046400.67045522
117Nicotine addiction_Homo sapiens_hsa050330.66943371
118Ovarian steroidogenesis_Homo sapiens_hsa049130.66340709
119Huntingtons disease_Homo sapiens_hsa050160.65875733
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.65862732
121Dopaminergic synapse_Homo sapiens_hsa047280.65789816
122Cocaine addiction_Homo sapiens_hsa050300.65561865
123Axon guidance_Homo sapiens_hsa043600.64763804
124Tryptophan metabolism_Homo sapiens_hsa003800.64639469
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.63339175
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63108378
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.61396984
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.60952244
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59512386
130Taste transduction_Homo sapiens_hsa047420.59137923
131Tight junction_Homo sapiens_hsa045300.59120892
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59113076
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59108537
134Starch and sucrose metabolism_Homo sapiens_hsa005000.59102785
135ErbB signaling pathway_Homo sapiens_hsa040120.58976891
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58781728
137Basal transcription factors_Homo sapiens_hsa030220.58523056
138Estrogen signaling pathway_Homo sapiens_hsa049150.58123158
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58073318
140Proteoglycans in cancer_Homo sapiens_hsa052050.57610426
141Long-term depression_Homo sapiens_hsa047300.57160489
142Circadian rhythm_Homo sapiens_hsa047100.57101329
143Insulin signaling pathway_Homo sapiens_hsa049100.56411382
144Melanoma_Homo sapiens_hsa052180.55438492
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54162829
146Gap junction_Homo sapiens_hsa045400.53339756
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51526780
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50780583
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49948541
150Glycerolipid metabolism_Homo sapiens_hsa005610.49221550
151Ribosome_Homo sapiens_hsa030100.48465303

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