KCNJ3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.08345453
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.91827182
3vocalization behavior (GO:0071625)5.73848821
4behavioral response to nicotine (GO:0035095)5.69146566
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.51156208
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.50003377
7membrane repolarization during action potential (GO:0086011)5.45379923
8synaptic vesicle exocytosis (GO:0016079)5.39941669
9locomotory exploration behavior (GO:0035641)5.36942158
10glutamate secretion (GO:0014047)5.33983969
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.22344918
12regulation of glutamate receptor signaling pathway (GO:1900449)5.07453996
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.00522078
14neuronal action potential propagation (GO:0019227)4.95631222
15synaptic vesicle maturation (GO:0016188)4.95530423
16protein localization to synapse (GO:0035418)4.86437323
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.81771303
18regulation of synaptic vesicle exocytosis (GO:2000300)4.80016471
19neuron cell-cell adhesion (GO:0007158)4.78884359
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76864255
21glutamate receptor signaling pathway (GO:0007215)4.64429115
22synaptic transmission, glutamatergic (GO:0035249)4.50161099
23neurotransmitter-gated ion channel clustering (GO:0072578)4.36233808
24exploration behavior (GO:0035640)4.35498200
25membrane repolarization (GO:0086009)4.34750621
26regulation of synaptic vesicle transport (GO:1902803)4.34006011
27neuron-neuron synaptic transmission (GO:0007270)4.31231221
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24204774
29regulation of membrane repolarization (GO:0060306)4.22840420
30gamma-aminobutyric acid signaling pathway (GO:0007214)4.18873765
31neurotransmitter secretion (GO:0007269)4.18258570
32positive regulation of synapse maturation (GO:0090129)4.13541370
33regulation of neuronal synaptic plasticity (GO:0048168)4.13492104
34parturition (GO:0007567)4.13392650
35potassium ion import (GO:0010107)4.11786807
36magnesium ion transport (GO:0015693)4.10335073
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08304407
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04818952
39negative regulation of synaptic transmission, GABAergic (GO:0032229)4.04556076
40regulation of skeletal muscle contraction (GO:0014819)3.96779580
41long-term memory (GO:0007616)3.90865472
42presynaptic membrane assembly (GO:0097105)3.90711557
43serotonin metabolic process (GO:0042428)3.86316263
44sulfation (GO:0051923)3.85820752
45regulation of postsynaptic membrane potential (GO:0060078)3.84811259
46gamma-aminobutyric acid transport (GO:0015812)3.80180346
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.76314414
48long-term synaptic potentiation (GO:0060291)3.75834974
49neuron recognition (GO:0008038)3.73674266
50positive regulation of membrane potential (GO:0045838)3.72203057
51postsynaptic membrane organization (GO:0001941)3.71570075
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71560643
53cellular potassium ion homeostasis (GO:0030007)3.70962862
54cerebellar granule cell differentiation (GO:0021707)3.70366230
55presynaptic membrane organization (GO:0097090)3.68488721
56regulation of synaptic plasticity (GO:0048167)3.64799725
57regulation of mesoderm development (GO:2000380)3.62306478
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.62150912
59regulation of synapse structural plasticity (GO:0051823)3.62016492
60proline transport (GO:0015824)3.61092424
61water-soluble vitamin biosynthetic process (GO:0042364)3.54190693
62cell proliferation in forebrain (GO:0021846)3.52570220
63cerebellar Purkinje cell differentiation (GO:0021702)3.52423698
64primary amino compound metabolic process (GO:1901160)3.50222370
65synaptic vesicle endocytosis (GO:0048488)3.48953734
66potassium ion homeostasis (GO:0055075)3.48514544
67cellular anion homeostasis (GO:0030002)3.47897183
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47815223
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.47550917
70NADH dehydrogenase complex assembly (GO:0010257)3.47550917
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47550917
72regulation of heart rate by cardiac conduction (GO:0086091)3.45713284
73response to histamine (GO:0034776)3.44219721
74layer formation in cerebral cortex (GO:0021819)3.43296967
75cell communication by electrical coupling (GO:0010644)3.42933092
76detection of calcium ion (GO:0005513)3.41574308
77neurotransmitter transport (GO:0006836)3.40605600
78regulation of dendritic spine morphogenesis (GO:0061001)3.40568329
79dendritic spine morphogenesis (GO:0060997)3.39901532
80regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.39734201
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39720071
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.37369940
83regulation of neurotransmitter secretion (GO:0046928)3.35970969
84axonal fasciculation (GO:0007413)3.35828616
85positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.34222024
86regulation of cell proliferation involved in kidney development (GO:1901722)3.34075947
87regulation of DNA endoreduplication (GO:0032875)3.31209164
88positive regulation of neurotransmitter secretion (GO:0001956)3.30244046
89membrane depolarization (GO:0051899)3.29982616
90cellular response to electrical stimulus (GO:0071257)3.29107969
91regulation of synapse maturation (GO:0090128)3.28521760
92multicellular organismal signaling (GO:0035637)3.28327612
93regulation of potassium ion transmembrane transport (GO:1901379)3.28322861
94membrane depolarization during action potential (GO:0086010)3.26690126
95behavioral defense response (GO:0002209)3.24299318
96behavioral fear response (GO:0001662)3.24299318
97regulation of glomerulus development (GO:0090192)3.23272474
98cardiac conduction (GO:0061337)3.23176643
99protein complex biogenesis (GO:0070271)3.21114191
100activation of protein kinase A activity (GO:0034199)3.21044676
101transmission of nerve impulse (GO:0019226)3.19950576
102regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.16219467
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15609748
104sodium ion export (GO:0071436)3.15586966
105fear response (GO:0042596)3.13121137
106regulation of neurotransmitter levels (GO:0001505)3.11756488
107regulation of vesicle fusion (GO:0031338)3.11145246
108relaxation of cardiac muscle (GO:0055119)3.10813962
109startle response (GO:0001964)3.10045205
110regulation of dendritic spine development (GO:0060998)3.05695821
111action potential (GO:0001508)3.04974411
112regulation of voltage-gated calcium channel activity (GO:1901385)3.03838113
113negative regulation of systemic arterial blood pressure (GO:0003085)3.03175944
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02316920
115innervation (GO:0060384)3.02211728
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01757878
117cellular response to ATP (GO:0071318)3.01139557
118learning (GO:0007612)3.01112220
119* synaptic transmission (GO:0007268)3.00197057
120neuronal action potential (GO:0019228)2.99741572
121cochlea development (GO:0090102)2.99713545
122regulation of synaptic transmission (GO:0050804)2.98797959
123regulation of neurotransmitter transport (GO:0051588)2.98336216
124long term synaptic depression (GO:0060292)2.98031535
125DNA deamination (GO:0045006)2.96907184
126vitamin catabolic process (GO:0009111)2.96533894
127fat-soluble vitamin catabolic process (GO:0042363)2.96533894
128positive regulation of synaptic transmission (GO:0050806)2.96404020
129positive regulation of neurotransmitter transport (GO:0051590)2.96238742
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93919500
131negative regulation of response to food (GO:0032096)2.93900496
132negative regulation of appetite (GO:0032099)2.93900496
133membrane hyperpolarization (GO:0060081)2.92734688
134neuromuscular process controlling balance (GO:0050885)2.92566022
135protein polyglutamylation (GO:0018095)2.91229150
136neuromuscular process controlling posture (GO:0050884)2.88657483
137positive regulation of potassium ion transmembrane transport (GO:1901381)2.88084504
138negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87241630
139positive regulation of synapse assembly (GO:0051965)2.86552845
140mitochondrial respiratory chain complex assembly (GO:0033108)2.86204095
141regulation of cell communication by electrical coupling (GO:0010649)2.85841113
142positive regulation of potassium ion transport (GO:0043268)2.84886166
143DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.81406180
144purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.81286230
1453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.81286230
146cardiac muscle cell action potential involved in contraction (GO:0086002)2.78076396
147positive regulation of cardiac muscle cell differentiation (GO:2000727)2.77582970
148ovulation cycle (GO:0042698)2.76207805
149cardiac muscle cell action potential (GO:0086001)2.73398508
150indole-containing compound metabolic process (GO:0042430)2.71229537
151positive regulation of meiosis (GO:0045836)2.70100781
152neuromuscular synaptic transmission (GO:0007274)2.66874317
153detection of light stimulus involved in visual perception (GO:0050908)2.65013395
154detection of light stimulus involved in sensory perception (GO:0050962)2.65013395
155positive regulation of fatty acid oxidation (GO:0046321)2.62718561
156mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59564678
157regulation of female receptivity (GO:0045924)2.59444649
158dentate gyrus development (GO:0021542)2.58299046
159establishment of protein localization to mitochondrial membrane (GO:0090151)2.58208522
160retinal ganglion cell axon guidance (GO:0031290)2.54838768
161interferon-gamma secretion (GO:0072643)2.54419384
162positive regulation of meiotic cell cycle (GO:0051446)2.54243762
163positive regulation of fatty acid beta-oxidation (GO:0032000)2.53154915
164indolalkylamine metabolic process (GO:0006586)2.50616680
165somite development (GO:0061053)2.50131542
166phosphate ion homeostasis (GO:0055062)2.49317654
167trivalent inorganic anion homeostasis (GO:0072506)2.49317654
168regulation of action potential (GO:0098900)2.47728485
169regulation of potassium ion transport (GO:0043266)2.46513998
170negative regulation of sodium ion transport (GO:0010766)2.45788639
171regulation of calcium ion-dependent exocytosis (GO:0017158)2.44970759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.36046968
2GBX2_23144817_ChIP-Seq_PC3_Human4.08779794
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.93695888
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18744893
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11294936
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09425413
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73020406
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.68892514
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68045620
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68045620
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65450770
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53315688
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50994143
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46368882
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.45280972
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44116605
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.42220370
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39658397
19DROSHA_22980978_ChIP-Seq_HELA_Human2.35006518
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.30467611
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.20620486
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.09912578
23TAF15_26573619_Chip-Seq_HEK293_Human2.09820845
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08946485
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08005267
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04919438
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02003523
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97360215
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94903482
30SMAD4_21799915_ChIP-Seq_A2780_Human1.88856603
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81863023
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78756184
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77620853
34* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77532052
35AR_21572438_ChIP-Seq_LNCaP_Human1.74107576
36IRF1_19129219_ChIP-ChIP_H3396_Human1.72813790
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71729964
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69612159
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68458734
40P300_19829295_ChIP-Seq_ESCs_Human1.64197514
41* EWS_26573619_Chip-Seq_HEK293_Human1.56549152
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54343591
43ZNF274_21170338_ChIP-Seq_K562_Hela1.53974831
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43075538
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.41970904
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41343713
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41232054
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40768715
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40271794
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39301984
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39244329
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39016799
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.38105398
54* AR_25329375_ChIP-Seq_VCAP_Human1.37760323
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37452117
56* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37014425
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36229592
58FUS_26573619_Chip-Seq_HEK293_Human1.35474482
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.32837565
60VDR_22108803_ChIP-Seq_LS180_Human1.32643324
61* PIAS1_25552417_ChIP-Seq_VCAP_Human1.32260471
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.31290251
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30989535
64STAT3_23295773_ChIP-Seq_U87_Human1.29694688
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27444461
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25593344
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22859203
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22736105
69* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22101644
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21910169
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21280514
72* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19997048
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.19506818
74* TCF4_23295773_ChIP-Seq_U87_Human1.19346128
75AR_19668381_ChIP-Seq_PC3_Human1.19093902
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18964053
77* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16076633
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14825470
79IGF1R_20145208_ChIP-Seq_DFB_Human1.14451768
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12611860
81TP53_16413492_ChIP-PET_HCT116_Human1.12073038
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10872089
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.09728556
84AHR_22903824_ChIP-Seq_MCF-7_Human1.08926656
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.07826799
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07395706
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07244674
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06764787
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06560626
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.05856293
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05847870
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05493232
93* CBP_20019798_ChIP-Seq_JUKART_Human1.05493232
94* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04694888
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.04630433
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04390541
97RNF2_27304074_Chip-Seq_NSC_Mouse1.03905920
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03901588
99RUNX2_22187159_ChIP-Seq_PCA_Human1.03001526
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02482889
101ER_23166858_ChIP-Seq_MCF-7_Human1.00099036
102BCAT_22108803_ChIP-Seq_LS180_Human0.99950688
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99606016
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98208668
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98208668
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98073070
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.98056912
108EP300_21415370_ChIP-Seq_HL-1_Mouse0.96896969
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96784588
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96624162
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95871691
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95501196
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.95501196
114TP53_18474530_ChIP-ChIP_U2OS_Human0.95487179
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95416237
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.94914090
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94737353
118TP53_22573176_ChIP-Seq_HFKS_Human0.94411035
119* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94402448
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.93877111
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93573236
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93486353
123MYC_18940864_ChIP-ChIP_HL60_Human0.93353631
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93161032
125* JUN_21703547_ChIP-Seq_K562_Human0.93103305
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.91535689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.40649910
2MP0003880_abnormal_central_pattern5.30805787
3MP0003635_abnormal_synaptic_transmissio4.14868662
4MP0004270_analgesia3.53993528
5MP0009745_abnormal_behavioral_response3.50634489
6MP0009046_muscle_twitch3.32246334
7MP0002063_abnormal_learning/memory/cond3.30622231
8MP0002064_seizures3.22532345
9MP0001968_abnormal_touch/_nociception3.11549836
10MP0002572_abnormal_emotion/affect_behav2.85754264
11MP0002272_abnormal_nervous_system2.70765314
12MP0002736_abnormal_nociception_after2.57746892
13MP0008877_abnormal_DNA_methylation2.51566964
14MP0002837_dystrophic_cardiac_calcinosis2.50885174
15MP0002734_abnormal_mechanical_nocicepti2.46615278
16MP0002735_abnormal_chemical_nociception2.42315312
17MP0001486_abnormal_startle_reflex2.40469697
18MP0001501_abnormal_sleep_pattern2.37064349
19MP0001440_abnormal_grooming_behavior2.27062022
20MP0006292_abnormal_olfactory_placode2.26243677
21MP0005423_abnormal_somatic_nervous2.16567203
22MP0002160_abnormal_reproductive_system2.09469136
23MP0002067_abnormal_sensory_capabilities2.08878042
24MP0009780_abnormal_chondrocyte_physiolo1.97941711
25MP0008569_lethality_at_weaning1.93954930
26MP0002822_catalepsy1.84363931
27MP0001970_abnormal_pain_threshold1.80481454
28MP0002733_abnormal_thermal_nociception1.79610862
29MP0004924_abnormal_behavior1.74406666
30MP0005386_behavior/neurological_phenoty1.74406666
31MP0003879_abnormal_hair_cell1.73695977
32MP0000751_myopathy1.73309356
33MP0002184_abnormal_innervation1.73169632
34MP0003329_amyloid_beta_deposits1.72506422
35MP0002638_abnormal_pupillary_reflex1.66442908
36MP0000778_abnormal_nervous_system1.65727894
37MP0002557_abnormal_social/conspecific_i1.63250920
38MP0004133_heterotaxia1.58934273
39MP0005389_reproductive_system_phenotype1.58621014
40* MP0004215_abnormal_myocardial_fiber1.57980774
41MP0006072_abnormal_retinal_apoptosis1.57643170
42MP0003787_abnormal_imprinting1.57492563
43MP0004811_abnormal_neuron_physiology1.56966506
44MP0000569_abnormal_digit_pigmentation1.56433332
45MP0005646_abnormal_pituitary_gland1.50851944
46MP0004145_abnormal_muscle_electrophysio1.47608561
47MP0006276_abnormal_autonomic_nervous1.46124368
48MP0003123_paternal_imprinting1.43819204
49MP0004484_altered_response_of1.41902777
50MP0003646_muscle_fatigue1.40518462
51MP0004858_abnormal_nervous_system1.38988090
52MP0002066_abnormal_motor_capabilities/c1.38938117
53MP0002909_abnormal_adrenal_gland1.38289219
54MP0002653_abnormal_ependyma_morphology1.36226413
55MP0001984_abnormal_olfaction1.36137667
56MP0003011_delayed_dark_adaptation1.34716630
57MP0000955_abnormal_spinal_cord1.34565207
58MP0003633_abnormal_nervous_system1.29863570
59MP0004142_abnormal_muscle_tone1.29538306
60MP0002882_abnormal_neuron_morphology1.29330488
61MP0003195_calcinosis1.26291863
62MP0002102_abnormal_ear_morphology1.25898430
63MP0003121_genomic_imprinting1.21710846
64MP0002938_white_spotting1.17113486
65MP0009379_abnormal_foot_pigmentation1.14369122
66MP0001529_abnormal_vocalization1.14112437
67* MP0004085_abnormal_heartbeat1.14017014
68MP0004510_myositis1.14007878
69MP0001188_hyperpigmentation1.13583320
70MP0001502_abnormal_circadian_rhythm1.12565030
71MP0003631_nervous_system_phenotype1.10879650
72MP0000049_abnormal_middle_ear1.09417207
73MP0001986_abnormal_taste_sensitivity1.09057472
74MP0005645_abnormal_hypothalamus_physiol1.08411571
75MP0001905_abnormal_dopamine_level1.07942420
76MP0003283_abnormal_digestive_organ1.07853515
77MP0003137_abnormal_impulse_conducting1.07050436
78MP0003122_maternal_imprinting1.05536347
79MP0004885_abnormal_endolymph1.04939371
80MP0002163_abnormal_gland_morphology1.04562744
81MP0004036_abnormal_muscle_relaxation1.03790390
82MP0001765_abnormal_ion_homeostasis1.03482807
83MP0005253_abnormal_eye_physiology1.02954245
84MP0000026_abnormal_inner_ear1.02816138
85MP0002152_abnormal_brain_morphology1.02161514
86MP0001919_abnormal_reproductive_system1.00525740
87MP0004084_abnormal_cardiac_muscle0.98486364
88MP0002928_abnormal_bile_duct0.97723547
89MP0004019_abnormal_vitamin_homeostasis0.92707670
90MP0004134_abnormal_chest_morphology0.92280810
91MP0003938_abnormal_ear_development0.91479256
92MP0008874_decreased_physiological_sensi0.89814399
93MP0000013_abnormal_adipose_tissue0.88652627
94MP0002876_abnormal_thyroid_physiology0.88336498
95MP0008872_abnormal_physiological_respon0.88214858
96MP0002229_neurodegeneration0.87278600
97MP0001963_abnormal_hearing_physiology0.86020651
98MP0002089_abnormal_postnatal_growth/wei0.85934270
99MP0002069_abnormal_eating/drinking_beha0.85520121
100MP0004742_abnormal_vestibular_system0.83634731
101MP0005620_abnormal_muscle_contractility0.83575979
102MP0005535_abnormal_body_temperature0.81921146
103MP0005084_abnormal_gallbladder_morpholo0.81810743
104MP0002972_abnormal_cardiac_muscle0.81026926
105MP0005174_abnormal_tail_pigmentation0.80799529
106MP0005195_abnormal_posterior_eye0.80686739
107MP0005379_endocrine/exocrine_gland_phen0.79766540
108MP0004233_abnormal_muscle_weight0.79454829
109MP0000230_abnormal_systemic_arterial0.79417632
110MP0003937_abnormal_limbs/digits/tail_de0.79398132
111MP0010386_abnormal_urinary_bladder0.79038506
112MP0003638_abnormal_response/metabolism_0.78996171
113MP0005551_abnormal_eye_electrophysiolog0.78804477
114MP0003119_abnormal_digestive_system0.78751248
115MP0000427_abnormal_hair_cycle0.78481913
116MP0004130_abnormal_muscle_cell0.76909310
117MP0003632_abnormal_nervous_system0.76018369
118MP0005448_abnormal_energy_balance0.75478537
119MP0000749_muscle_degeneration0.70431271
120MP0001485_abnormal_pinna_reflex0.69368951
121MP0000604_amyloidosis0.68232704
122MP0005623_abnormal_meninges_morphology0.65658933
123MP0002752_abnormal_somatic_nervous0.64893660
124MP0005330_cardiomyopathy0.62645345
125MP0001177_atelectasis0.61598469
126MP0006138_congestive_heart_failure0.61556814
127MP0003634_abnormal_glial_cell0.61342383
128MP0004043_abnormal_pH_regulation0.60313117
129MP0003075_altered_response_to0.60041495
130MP0003690_abnormal_glial_cell0.59149596
131MP0005187_abnormal_penis_morphology0.58360543
132MP0000631_abnormal_neuroendocrine_gland0.58349009
133MP0005171_absent_coat_pigmentation0.55212465
134MP0001664_abnormal_digestion0.55157809
135MP0008961_abnormal_basal_metabolism0.54881218
136MP0000920_abnormal_myelination0.54799948
137MP0010769_abnormal_survival0.52866668
138MP0005499_abnormal_olfactory_system0.52828149
139MP0005394_taste/olfaction_phenotype0.52828149

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.91618646
2Focal seizures (HP:0007359)5.97973512
3Myokymia (HP:0002411)5.79691178
4Epileptic encephalopathy (HP:0200134)5.62017748
5Atonic seizures (HP:0010819)5.60402849
6Visual hallucinations (HP:0002367)5.19612577
7Febrile seizures (HP:0002373)5.15119155
8Absence seizures (HP:0002121)4.74361109
9Hyperventilation (HP:0002883)4.68120754
10Progressive cerebellar ataxia (HP:0002073)4.43616337
11Dialeptic seizures (HP:0011146)4.35773271
12Generalized tonic-clonic seizures (HP:0002069)4.07968807
13Broad-based gait (HP:0002136)4.05957753
14Gaze-evoked nystagmus (HP:0000640)3.78181238
15Action tremor (HP:0002345)3.68036520
16Poor eye contact (HP:0000817)3.59133316
17Dysdiadochokinesis (HP:0002075)3.33509304
18Pancreatic cysts (HP:0001737)3.27612351
19Abnormal social behavior (HP:0012433)3.23741947
20Impaired social interactions (HP:0000735)3.23741947
21Amblyopia (HP:0000646)3.18912333
22Impaired vibration sensation in the lower limbs (HP:0002166)3.12384148
23Pancreatic fibrosis (HP:0100732)3.09874931
24Nephronophthisis (HP:0000090)3.07964456
25Truncal ataxia (HP:0002078)3.04842074
26Dysmetria (HP:0001310)3.02699241
27True hermaphroditism (HP:0010459)3.00079477
28Congenital stationary night blindness (HP:0007642)2.98628956
29Dysmetric saccades (HP:0000641)2.98063415
30Depression (HP:0000716)2.89661796
31Osteomalacia (HP:0002749)2.89462764
32Drooling (HP:0002307)2.88634214
33Excessive salivation (HP:0003781)2.88634214
34Anxiety (HP:0000739)2.80385898
35Sudden death (HP:0001699)2.78935135
36Impaired smooth pursuit (HP:0007772)2.78428441
37Abolished electroretinogram (ERG) (HP:0000550)2.76590765
38Molar tooth sign on MRI (HP:0002419)2.76108112
39Abnormality of midbrain morphology (HP:0002418)2.76108112
40Epileptiform EEG discharges (HP:0011182)2.76064707
41Abnormality of binocular vision (HP:0011514)2.75702536
42Diplopia (HP:0000651)2.75702536
43Pendular nystagmus (HP:0012043)2.75586715
44Supranuclear gaze palsy (HP:0000605)2.74371234
45Urinary bladder sphincter dysfunction (HP:0002839)2.69019192
46Abnormal eating behavior (HP:0100738)2.68043049
47Decreased circulating renin level (HP:0003351)2.67014814
48Scanning speech (HP:0002168)2.66734311
49Limb dystonia (HP:0002451)2.63798323
50Abnormality of the lower motor neuron (HP:0002366)2.62880337
51Genetic anticipation (HP:0003743)2.58865458
52Progressive inability to walk (HP:0002505)2.56891303
53Postural instability (HP:0002172)2.56798905
54Abnormality of the proximal phalanges of the hand (HP:0009834)2.54517977
55Congenital, generalized hypertrichosis (HP:0004540)2.54067308
56Agitation (HP:0000713)2.53767246
57Hemiparesis (HP:0001269)2.53103551
58Inability to walk (HP:0002540)2.50949188
59Ventricular fibrillation (HP:0001663)2.50922019
60Abnormality of the renal medulla (HP:0100957)2.50238950
61EEG with generalized epileptiform discharges (HP:0011198)2.49384872
62Syncope (HP:0001279)2.48909160
63Pheochromocytoma (HP:0002666)2.47913783
64Methylmalonic acidemia (HP:0002912)2.47859570
65Absent speech (HP:0001344)2.44964083
66Asplenia (HP:0001746)2.44274125
67Small hand (HP:0200055)2.43094490
68Ankle clonus (HP:0011448)2.38542146
69Abnormality of ocular smooth pursuit (HP:0000617)2.38114880
70Conjunctival hamartoma (HP:0100780)2.37200089
71Status epilepticus (HP:0002133)2.36226350
72Stereotypic behavior (HP:0000733)2.31676018
73Hypsarrhythmia (HP:0002521)2.31563856
74Protruding tongue (HP:0010808)2.30835646
75Aplasia/Hypoplasia of the spleen (HP:0010451)2.30424604
76Abnormality of the middle phalanges of the toes (HP:0010183)2.29285841
77Short 1st metacarpal (HP:0010034)2.29282164
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.29282164
79Urinary urgency (HP:0000012)2.29028160
80Bradykinesia (HP:0002067)2.28903001
81Bundle branch block (HP:0011710)2.28897561
82Cerebral inclusion bodies (HP:0100314)2.27713642
83Confusion (HP:0001289)2.27488073
84Fetal akinesia sequence (HP:0001989)2.27092685
85Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26483556
86Short hallux (HP:0010109)2.26268007
87Abnormality of the renal cortex (HP:0011035)2.25928020
88Termporal pattern (HP:0011008)2.24921348
89Insidious onset (HP:0003587)2.24921348
90Short femoral neck (HP:0100864)2.22000045
91Hemiplegia (HP:0002301)2.21854609
92Neuroendocrine neoplasm (HP:0100634)2.20482386
93Abnormal rod and cone electroretinograms (HP:0008323)2.19899747
94Aplasia/Hypoplasia of the hallux (HP:0008362)2.19869125
95Aplasia/Hypoplasia of the tibia (HP:0005772)2.18932957
96Impaired vibratory sensation (HP:0002495)2.18803531
97Furrowed tongue (HP:0000221)2.16340034
98Medial flaring of the eyebrow (HP:0010747)2.16012936
99Mutism (HP:0002300)2.15502380
100Oligodontia (HP:0000677)2.14956463
101Generalized myoclonic seizures (HP:0002123)2.09920096
102Decreased central vision (HP:0007663)2.09863449
103Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.09578543
104Fibular aplasia (HP:0002990)2.08661159
1053-Methylglutaconic aciduria (HP:0003535)2.08342832
106Primary atrial arrhythmia (HP:0001692)2.08279576
107Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08017748
108Spastic gait (HP:0002064)2.07821563
109Atrial fibrillation (HP:0005110)2.07667272
110Intention tremor (HP:0002080)2.07515146
111Type II lissencephaly (HP:0007260)2.07503964
112Short tibia (HP:0005736)2.04530550
113Cystic liver disease (HP:0006706)2.04238810
114Symphalangism affecting the phalanges of the hand (HP:0009773)2.03904748
115Persistence of primary teeth (HP:0006335)2.03527541
116Abnormality of the corticospinal tract (HP:0002492)2.03162327
117Metabolic alkalosis (HP:0200114)2.02595760
118Clumsiness (HP:0002312)2.02463314
119Muscle hypertrophy of the lower extremities (HP:0008968)1.99633994
120Abnormality of the 1st metacarpal (HP:0010009)1.99186730
121Calf muscle hypertrophy (HP:0008981)1.98749268
122Male pseudohermaphroditism (HP:0000037)1.98438400
123Chronic hepatic failure (HP:0100626)1.97678802
124Blue irides (HP:0000635)1.97299563
125Abnormal EKG (HP:0003115)1.97180017
126Gait ataxia (HP:0002066)1.95900451
127Supraventricular tachycardia (HP:0004755)1.95794020
128Abnormality of the phalanges of the 5th finger (HP:0004213)1.95703779
129Papilledema (HP:0001085)1.95267376
130Exercise-induced myalgia (HP:0003738)1.94673471
131Incomplete penetrance (HP:0003829)1.94221863
132Abnormality of the frontal sinuses (HP:0002687)1.92222842
133Specific learning disability (HP:0001328)1.91342384
134Mitochondrial inheritance (HP:0001427)1.91149120
135Polydipsia (HP:0001959)1.91057094
136Abnormal drinking behavior (HP:0030082)1.91057094
137Aplasia/hypoplasia of the uterus (HP:0008684)1.90168132
138Abnormality of salivation (HP:0100755)1.90057481
139Prolonged QT interval (HP:0001657)1.89483735
140Hypoplasia of the uterus (HP:0000013)1.89336932
141Bony spicule pigmentary retinopathy (HP:0007737)1.89214142
142Neurofibrillary tangles (HP:0002185)1.89159104
143Congenital sensorineural hearing impairment (HP:0008527)1.88824141
144Hypoplasia of the ulna (HP:0003022)1.88759716
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.88115123
146Absent/shortened dynein arms (HP:0200106)1.88115123
147Supraventricular arrhythmia (HP:0005115)1.87913499
148Delusions (HP:0000746)1.87559292
149Methylmalonic aciduria (HP:0012120)1.87095450
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87020674
151Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.86408459
152Renal cortical cysts (HP:0000803)1.86183151
153Abnormality of renal resorption (HP:0011038)1.86117628
154Hamartoma of the eye (HP:0010568)1.84712627
155Lower limb muscle weakness (HP:0007340)1.84109273
156Acute necrotizing encephalopathy (HP:0006965)1.83991209
157Goiter (HP:0000853)1.83929966
158Psychosis (HP:0000709)1.83027332
159Polyphagia (HP:0002591)1.82921505
160Preauricular pit (HP:0004467)1.82648559
161Periauricular skin pits (HP:0100277)1.82648559
162Concave nail (HP:0001598)1.82121669
163Attenuation of retinal blood vessels (HP:0007843)1.82111796
164Abnormality of the calf musculature (HP:0001430)1.81793845
165Abnormal mitochondria in muscle tissue (HP:0008316)1.81485892
166Progressive macrocephaly (HP:0004481)1.77516245
167Rapidly progressive (HP:0003678)1.77490329
168Focal dystonia (HP:0004373)1.76524339
169Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74027481
170Gait imbalance (HP:0002141)1.73819064
171Torticollis (HP:0000473)1.71404748
172Myotonia (HP:0002486)1.70265267
173Lower limb asymmetry (HP:0100559)1.70092757
174Horizontal nystagmus (HP:0000666)1.70024700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.70914722
2EPHA44.29835043
3FRK4.20761805
4CASK3.44023391
5MAP3K43.26353538
6TLK13.25353794
7MAP3K93.24487651
8GRK12.91920700
9MAP2K72.88906679
10ADRBK22.76982641
11DAPK22.55445677
12MAP3K122.53666565
13BMPR1B2.40535313
14MINK12.34125097
15MARK12.31784651
16RIPK42.23587020
17WNK42.17667421
18ACVR1B2.15242083
19ZAK2.14810532
20MAP2K42.11745612
21PLK22.04253010
22DAPK11.99861764
23CDK191.94597864
24PAK61.88482381
25TAOK31.74630547
26KSR21.65062372
27NTRK21.61875558
28PRPF4B1.57337158
29WNK31.56279573
30CAMKK11.53881127
31KSR11.50336265
32GRK51.48971491
33STK391.43032254
34PNCK1.41576490
35PRKD31.39148760
36CDK51.37322382
37CAMKK21.31124636
38CCNB11.28139039
39PRKCG1.27268624
40TNIK1.25605092
41CAMK2A1.21934655
42MAP4K21.21782077
43ARAF1.20869120
44STK381.20655991
45NTRK11.17831218
46SIK21.17772858
47PTK2B1.17316079
48INSRR1.16938333
49MAPK131.16571559
50AKT31.16236836
51PIK3CA1.14358410
52NUAK11.12504380
53PHKG11.11110964
54PHKG21.11110964
55TAF11.09713441
56BMPR21.04542085
57MAPKAPK31.04142020
58OXSR11.03197069
59FES1.01373284
60CAMK11.01119548
61ADRBK11.00909839
62CAMK2B0.99854568
63FGFR20.93056685
64STK160.92771756
65PDK30.92584204
66PDK40.92584204
67SGK20.90642207
68SGK4940.89551950
69SGK2230.89551950
70MAP3K130.88686913
71TXK0.85941588
72DYRK20.85012961
73LMTK20.84565209
74UHMK10.83411792
75MAP3K20.82079070
76NME10.81497001
77MAP2K60.78983345
78CSNK1G20.78692518
79RAF10.78391139
80PINK10.76520786
81STK110.75787726
82GRK70.75743237
83CDK180.75548797
84SGK10.75283001
85CAMK2D0.72776200
86* PRKACA0.72266581
87CDK150.72097260
88PAK30.71843810
89VRK10.71345695
90CDK140.68983792
91RPS6KA20.68557324
92SGK30.68242399
93MAPKAPK50.66470618
94PRKCE0.65929116
95LATS20.65466451
96PKN10.65076061
97TYRO30.65039572
98MUSK0.64246263
99FGR0.62571809
100RPS6KA60.61945310
101CDK11A0.61757353
102PRKCH0.61668364
103RET0.61334819
104PDK10.61266948
105CSNK1A10.59021588
106DYRK1A0.58677655
107MAP2K20.58483487
108PRKD20.57807667
109PDPK10.56511167
110FER0.54612537
111CAMK2G0.53955718
112CAMK40.53705658
113DMPK0.52891670
114DAPK30.52805941
115MAPK120.51585928
116PRKCA0.50917325
117ERBB20.49667209
118SIK30.48708737
119MAP3K60.48045767
120MAP3K70.47447840
121NEK10.46986287
122IKBKB0.45926987
123PRKCI0.45815466
124BRAF0.45307293
125PDK20.45192002
126MYLK0.44583634
127RPS6KA30.44321471
128WNK10.44303357
129CSNK1G30.44119395
130PRKG10.44093254
131TIE10.43676286
132MAP3K10.43071025
133ROCK20.43027877
134CSNK1G10.40466106
135OBSCN0.39676402
136TAOK10.39126356
137CDC42BPA0.39006002
138MAP2K10.38706130
139TNK20.37098229
140PRKCQ0.36575980
141CSNK1A1L0.36392595
142FYN0.35390396
143CAMK1G0.35319791
144PRKACG0.35278022
145PRKCZ0.34205570
146MARK20.33959772

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.20417472
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30737379
3Long-term potentiation_Homo sapiens_hsa047202.96261809
4* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82988530
5* Circadian entrainment_Homo sapiens_hsa047132.68791555
6GABAergic synapse_Homo sapiens_hsa047272.61558372
7* Glutamatergic synapse_Homo sapiens_hsa047242.59378486
8Amphetamine addiction_Homo sapiens_hsa050312.53613956
9Olfactory transduction_Homo sapiens_hsa047402.47083711
10* Morphine addiction_Homo sapiens_hsa050322.41318277
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.25715412
12Salivary secretion_Homo sapiens_hsa049702.23061522
13* Dopaminergic synapse_Homo sapiens_hsa047282.01562721
14Insulin secretion_Homo sapiens_hsa049111.99062347
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98985373
16Collecting duct acid secretion_Homo sapiens_hsa049661.97272912
17Taste transduction_Homo sapiens_hsa047421.96398589
18Gastric acid secretion_Homo sapiens_hsa049711.87354189
19Long-term depression_Homo sapiens_hsa047301.77730943
20Calcium signaling pathway_Homo sapiens_hsa040201.77615140
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77083971
22Renin secretion_Homo sapiens_hsa049241.76492470
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75721694
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74211046
25* Oxytocin signaling pathway_Homo sapiens_hsa049211.67740331
26* Cholinergic synapse_Homo sapiens_hsa047251.65147613
27Cardiac muscle contraction_Homo sapiens_hsa042601.63752166
28* Serotonergic synapse_Homo sapiens_hsa047261.57897591
29Linoleic acid metabolism_Homo sapiens_hsa005911.55569631
30Nitrogen metabolism_Homo sapiens_hsa009101.42246943
31GnRH signaling pathway_Homo sapiens_hsa049121.37038002
32cAMP signaling pathway_Homo sapiens_hsa040241.30915617
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30697868
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28226805
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27127835
36Cocaine addiction_Homo sapiens_hsa050301.25639178
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24152983
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22636824
39Sulfur metabolism_Homo sapiens_hsa009201.21205344
40Gap junction_Homo sapiens_hsa045401.20536550
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20268148
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20139451
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17520978
44Type II diabetes mellitus_Homo sapiens_hsa049301.17390556
45Oxidative phosphorylation_Homo sapiens_hsa001901.16484228
46Vitamin digestion and absorption_Homo sapiens_hsa049771.16253034
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15551108
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15166399
49Vibrio cholerae infection_Homo sapiens_hsa051101.13681864
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13054723
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10899127
52Dilated cardiomyopathy_Homo sapiens_hsa054141.09327046
53Alzheimers disease_Homo sapiens_hsa050101.09225513
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.07936770
55Tryptophan metabolism_Homo sapiens_hsa003801.02072127
56Axon guidance_Homo sapiens_hsa043601.00395684
57Chemical carcinogenesis_Homo sapiens_hsa052040.99885001
58Protein export_Homo sapiens_hsa030600.99827986
59Caffeine metabolism_Homo sapiens_hsa002320.99072336
60* Estrogen signaling pathway_Homo sapiens_hsa049150.97858549
61Retinol metabolism_Homo sapiens_hsa008300.97399961
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.96606652
63Glioma_Homo sapiens_hsa052140.96501732
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96444085
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94858398
66Ribosome_Homo sapiens_hsa030100.94775356
67Melanogenesis_Homo sapiens_hsa049160.94623815
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93837663
69Basal transcription factors_Homo sapiens_hsa030220.91819469
70Butanoate metabolism_Homo sapiens_hsa006500.90910564
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90485088
72ErbB signaling pathway_Homo sapiens_hsa040120.90358667
73RNA degradation_Homo sapiens_hsa030180.90103233
74Ether lipid metabolism_Homo sapiens_hsa005650.86773156
75Pancreatic secretion_Homo sapiens_hsa049720.86088262
76Melanoma_Homo sapiens_hsa052180.85372789
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85000598
78Selenocompound metabolism_Homo sapiens_hsa004500.84324937
79Homologous recombination_Homo sapiens_hsa034400.81782608
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.81011194
81Oocyte meiosis_Homo sapiens_hsa041140.79408987
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78472520
83Parkinsons disease_Homo sapiens_hsa050120.76989434
84Dorso-ventral axis formation_Homo sapiens_hsa043200.73127764
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73065811
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72545367
87Phototransduction_Homo sapiens_hsa047440.72523812
88Glucagon signaling pathway_Homo sapiens_hsa049220.72072221
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70822808
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70518998
91MAPK signaling pathway_Homo sapiens_hsa040100.67176933
92Thyroid hormone synthesis_Homo sapiens_hsa049180.66806399
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64374006
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.64181178
95Histidine metabolism_Homo sapiens_hsa003400.63516863
96Regulation of autophagy_Homo sapiens_hsa041400.63070721
97Choline metabolism in cancer_Homo sapiens_hsa052310.60295731
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59914415
99Huntingtons disease_Homo sapiens_hsa050160.59553882
100Mineral absorption_Homo sapiens_hsa049780.58269273
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57990970
102Systemic lupus erythematosus_Homo sapiens_hsa053220.57591163
103RNA polymerase_Homo sapiens_hsa030200.56233801
104VEGF signaling pathway_Homo sapiens_hsa043700.55291919
105Peroxisome_Homo sapiens_hsa041460.54005092
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51902422
107Glycerolipid metabolism_Homo sapiens_hsa005610.51120129
108Ras signaling pathway_Homo sapiens_hsa040140.50417649
109Inositol phosphate metabolism_Homo sapiens_hsa005620.49680375
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48352261
111Hedgehog signaling pathway_Homo sapiens_hsa043400.45901831
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.45836207
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45572462
114Circadian rhythm_Homo sapiens_hsa047100.45232311
115Asthma_Homo sapiens_hsa053100.44304972
116Fanconi anemia pathway_Homo sapiens_hsa034600.44234885
117Rap1 signaling pathway_Homo sapiens_hsa040150.44206286
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43833921
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41833330
120mTOR signaling pathway_Homo sapiens_hsa041500.39114030
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38390428
122African trypanosomiasis_Homo sapiens_hsa051430.37623819
123Insulin signaling pathway_Homo sapiens_hsa049100.37599174
124Arachidonic acid metabolism_Homo sapiens_hsa005900.37286273
125Type I diabetes mellitus_Homo sapiens_hsa049400.36281743
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.35969012
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.35354093
128Basal cell carcinoma_Homo sapiens_hsa052170.35193524
129Rheumatoid arthritis_Homo sapiens_hsa053230.34876699
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33901760
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33783282
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33079824
133Wnt signaling pathway_Homo sapiens_hsa043100.33078973
134Bile secretion_Homo sapiens_hsa049760.30935916
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29511358
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29385265
137Alcoholism_Homo sapiens_hsa050340.28988327
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28342476
139Renal cell carcinoma_Homo sapiens_hsa052110.28056900
140Ovarian steroidogenesis_Homo sapiens_hsa049130.25229431
141Prion diseases_Homo sapiens_hsa050200.24256514
142Endocytosis_Homo sapiens_hsa041440.23288034
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20871724
144Non-small cell lung cancer_Homo sapiens_hsa052230.20149352

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