KCNJ6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08429724
2glutamate secretion (GO:0014047)5.54238178
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30873949
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.28764071
5synaptic vesicle exocytosis (GO:0016079)5.20796381
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19507130
7glutamate receptor signaling pathway (GO:0007215)5.15776068
8vocalization behavior (GO:0071625)5.07276757
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00163115
10protein localization to synapse (GO:0035418)4.94121194
11locomotory exploration behavior (GO:0035641)4.93612329
12G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.88721707
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.81686044
14synaptic vesicle maturation (GO:0016188)4.81100137
15regulation of glutamate receptor signaling pathway (GO:1900449)4.77050455
16synaptic transmission, glutamatergic (GO:0035249)4.76729655
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.58367257
18regulation of synaptic vesicle exocytosis (GO:2000300)4.47383269
19neuron cell-cell adhesion (GO:0007158)4.45965148
20neuron-neuron synaptic transmission (GO:0007270)4.39578526
21behavioral response to nicotine (GO:0035095)4.35129665
22regulation of neuronal synaptic plasticity (GO:0048168)4.32800607
23neuronal action potential propagation (GO:0019227)4.28367555
24cellular ketone body metabolic process (GO:0046950)4.24935813
25regulation of synaptic vesicle transport (GO:1902803)4.18917683
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09747304
27long-term memory (GO:0007616)4.08690428
28exploration behavior (GO:0035640)4.06348622
29positive regulation of synapse maturation (GO:0090129)4.04317381
30neurotransmitter-gated ion channel clustering (GO:0072578)3.95856181
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87238389
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.83141058
33neurotransmitter secretion (GO:0007269)3.81742654
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81352275
35ketone body metabolic process (GO:1902224)3.75039852
36long-term synaptic potentiation (GO:0060291)3.74880400
37regulation of postsynaptic membrane potential (GO:0060078)3.73324287
38regulation of synaptic plasticity (GO:0048167)3.71063374
39membrane depolarization during action potential (GO:0086010)3.70562209
40neuron recognition (GO:0008038)3.70532357
41presynaptic membrane assembly (GO:0097105)3.67635975
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.65924506
43regulation of vesicle fusion (GO:0031338)3.65094995
44serotonin metabolic process (GO:0042428)3.61988241
45cerebellar Purkinje cell differentiation (GO:0021702)3.56544022
46positive regulation of membrane potential (GO:0045838)3.56154543
47dendritic spine morphogenesis (GO:0060997)3.51988964
48negative regulation of amino acid transport (GO:0051956)3.50847721
49detection of light stimulus involved in sensory perception (GO:0050962)3.50703698
50detection of light stimulus involved in visual perception (GO:0050908)3.50703698
51protein polyglutamylation (GO:0018095)3.48046872
52regulation of glutamate secretion (GO:0014048)3.46195065
53axonal fasciculation (GO:0007413)3.45639982
54neuronal action potential (GO:0019228)3.45559844
55presynaptic membrane organization (GO:0097090)3.45104447
56startle response (GO:0001964)3.44112788
57response to histamine (GO:0034776)3.43690252
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41657098
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.39930271
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.37082429
61membrane depolarization (GO:0051899)3.37080978
62innervation (GO:0060384)3.35677927
63postsynaptic membrane organization (GO:0001941)3.34584231
64regulation of synapse maturation (GO:0090128)3.33410672
65dendrite morphogenesis (GO:0048813)3.32971285
66transmission of nerve impulse (GO:0019226)3.32846750
67regulation of neurotransmitter secretion (GO:0046928)3.31452397
68calcium ion-dependent exocytosis (GO:0017156)3.30350604
69cellular potassium ion homeostasis (GO:0030007)3.29923253
70behavioral fear response (GO:0001662)3.27884867
71behavioral defense response (GO:0002209)3.27884867
72neurotransmitter transport (GO:0006836)3.25956813
73dendritic spine organization (GO:0097061)3.24435892
74L-fucose catabolic process (GO:0042355)3.23945577
75fucose catabolic process (GO:0019317)3.23945577
76L-fucose metabolic process (GO:0042354)3.23945577
77regulation of sarcomere organization (GO:0060297)3.22638457
78synaptic vesicle endocytosis (GO:0048488)3.22139314
79gamma-aminobutyric acid transport (GO:0015812)3.19316672
80sperm motility (GO:0030317)3.18787672
81cellular sodium ion homeostasis (GO:0006883)3.15484484
82proline transport (GO:0015824)3.14948216
83negative regulation of translation, ncRNA-mediated (GO:0040033)3.14939019
84regulation of translation, ncRNA-mediated (GO:0045974)3.14939019
85negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.14939019
86chemosensory behavior (GO:0007635)3.14200686
87regulation of synapse structural plasticity (GO:0051823)3.14075507
88fear response (GO:0042596)3.11715363
89indolalkylamine metabolic process (GO:0006586)3.10625580
90central nervous system projection neuron axonogenesis (GO:0021952)3.10485606
91regulation of calcium ion-dependent exocytosis (GO:0017158)3.10379153
92indole-containing compound catabolic process (GO:0042436)3.10212472
93indolalkylamine catabolic process (GO:0046218)3.10212472
94tryptophan catabolic process (GO:0006569)3.10212472
95inner ear receptor cell development (GO:0060119)3.10130684
96primary amino compound metabolic process (GO:1901160)3.08547678
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08390301
98learning (GO:0007612)3.07502385
99reflex (GO:0060004)3.07391128
100regulation of dendritic spine morphogenesis (GO:0061001)3.06991133
101regulation of synaptic transmission (GO:0050804)3.06776549
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05963033
103detection of calcium ion (GO:0005513)3.05035492
104positive regulation of dendritic spine morphogenesis (GO:0061003)3.04765962
105cochlea development (GO:0090102)3.03537865
106* synaptic transmission (GO:0007268)3.03034677
107positive regulation of fibroblast migration (GO:0010763)3.02160087
108calcium ion import (GO:0070509)3.01503770
109regulation of neurotransmitter transport (GO:0051588)3.01460022
110cerebellar granule cell differentiation (GO:0021707)3.01029733
111dopamine biosynthetic process (GO:0042416)3.00583026
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00307998
113regulation of neurotransmitter levels (GO:0001505)2.98516840
114positive regulation of neurotransmitter secretion (GO:0001956)2.98151046
115cAMP catabolic process (GO:0006198)2.96856008
116indole-containing compound metabolic process (GO:0042430)2.96733717
117kynurenine metabolic process (GO:0070189)2.96555719
118behavioral response to cocaine (GO:0048148)2.95664001
119auditory behavior (GO:0031223)2.95633380
120establishment of protein localization to Golgi (GO:0072600)2.95321830
121acrosome reaction (GO:0007340)2.92790100
122social behavior (GO:0035176)2.92193469
123intraspecies interaction between organisms (GO:0051703)2.92193469
124regulation of inositol phosphate biosynthetic process (GO:0010919)2.91913781
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91869696
126nephron tubule morphogenesis (GO:0072078)2.91481412
127nephron epithelium morphogenesis (GO:0072088)2.91481412
128positive regulation of synaptic transmission (GO:0050806)2.91389239
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89273084
130negative regulation of neurotransmitter transport (GO:0051589)2.89110245
131insulin secretion (GO:0030073)2.88001912
132sleep (GO:0030431)2.87914889
133peristalsis (GO:0030432)2.86109075
134cyclic nucleotide catabolic process (GO:0009214)2.85821652
135neuromuscular synaptic transmission (GO:0007274)2.83255614
136response to pheromone (GO:0019236)2.79408845
137alanine transport (GO:0032328)2.76969496
138musculoskeletal movement (GO:0050881)2.76819265
139multicellular organismal movement (GO:0050879)2.76819265
140regulation of action potential (GO:0098900)2.75455661
141urinary tract smooth muscle contraction (GO:0014848)2.72304790
142regulation of neurotransmitter uptake (GO:0051580)2.71696811
143membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.67083149
144signal peptide processing (GO:0006465)2.65891802
145spinal cord motor neuron differentiation (GO:0021522)2.65310766
146regulation of cilium movement (GO:0003352)2.64465340
147renal tubule morphogenesis (GO:0061333)2.64033021
148action potential (GO:0001508)2.62291814
149protein localization to cilium (GO:0061512)2.60051933
150adaptation of signaling pathway (GO:0023058)2.59244199
151glycerophospholipid catabolic process (GO:0046475)2.59021304
152regulation of glucokinase activity (GO:0033131)2.57568394
153regulation of hexokinase activity (GO:1903299)2.57568394
154* cellular potassium ion transport (GO:0071804)2.54282944
155* potassium ion transmembrane transport (GO:0071805)2.54282944
156multicellular organismal signaling (GO:0035637)2.54148750
157regulation of female gonad development (GO:2000194)2.54136854
158positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.53870468
159tryptophan metabolic process (GO:0006568)2.53141694
160nonmotile primary cilium assembly (GO:0035058)2.52276127
161protein targeting to Golgi (GO:0000042)2.50728262
162positive regulation of meiosis (GO:0045836)2.50047166
163regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.50031493
164regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.50031493
165detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49848418
166dopamine transport (GO:0015872)2.49778850
167cilium or flagellum-dependent cell motility (GO:0001539)2.48983735
168multicellular organism reproduction (GO:0032504)2.47978959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human6.03301103
2GBX2_23144817_ChIP-Seq_PC3_Human4.30223095
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08338484
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03722692
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98682457
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95139674
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58095593
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56408359
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56408359
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56286749
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55019956
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.54533049
13DROSHA_22980978_ChIP-Seq_HELA_Human2.45050333
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.44410181
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38385627
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35382478
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35191545
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.30634426
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16400892
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.15899939
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.14498522
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14079123
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11901329
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.09169104
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04334019
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01808336
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.97684046
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96628618
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94383384
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87484895
31SMAD4_21799915_ChIP-Seq_A2780_Human1.83425637
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80180323
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78012547
34TAF15_26573619_Chip-Seq_HEK293_Human1.71919830
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65226262
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63722710
37P300_19829295_ChIP-Seq_ESCs_Human1.57653138
38ZNF274_21170338_ChIP-Seq_K562_Hela1.57512895
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50752055
40AR_21572438_ChIP-Seq_LNCaP_Human1.46301793
41IGF1R_20145208_ChIP-Seq_DFB_Human1.44609586
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43736875
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.43469712
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42257081
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40486292
46* STAT3_23295773_ChIP-Seq_U87_Human1.40190261
47FUS_26573619_Chip-Seq_HEK293_Human1.39956734
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39688977
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.38947875
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.38495107
51* BCAT_22108803_ChIP-Seq_LS180_Human1.37803476
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37033114
53CBP_20019798_ChIP-Seq_JUKART_Human1.35844206
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35844206
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35581593
56* AR_25329375_ChIP-Seq_VCAP_Human1.33837605
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31679734
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31356207
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29661231
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28096888
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26707732
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26628639
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26209261
64* TCF4_23295773_ChIP-Seq_U87_Human1.26054834
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20274580
66* AR_19668381_ChIP-Seq_PC3_Human1.19805687
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18221999
68* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17887787
69* SMAD4_21741376_ChIP-Seq_EPCs_Human1.16774514
70VDR_22108803_ChIP-Seq_LS180_Human1.15507544
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.15218594
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.15164266
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15163252
74RNF2_27304074_Chip-Seq_NSC_Mouse1.14977602
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14319217
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13176852
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12666456
78EWS_26573619_Chip-Seq_HEK293_Human1.12416445
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.12261836
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11593944
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.11516665
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.10843357
83TP53_16413492_ChIP-PET_HCT116_Human1.10352239
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09611372
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09611372
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07895341
87* TCF4_22108803_ChIP-Seq_LS180_Human1.07286370
88* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06692322
89TP53_22573176_ChIP-Seq_HFKS_Human1.06356074
90KDM2B_26808549_Chip-Seq_REH_Human1.06343568
91NANOG_19829295_ChIP-Seq_ESCs_Human1.06181570
92SOX2_19829295_ChIP-Seq_ESCs_Human1.06181570
93* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06059948
94RUNX2_22187159_ChIP-Seq_PCA_Human1.05781988
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05602880
96* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05073099
97* SMAD3_21741376_ChIP-Seq_ESCs_Human1.04951885
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04654617
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04385038
100TP53_18474530_ChIP-ChIP_U2OS_Human1.04301935
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03679521
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03575760
103* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03369290
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02708645
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.02395818
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01935336
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01420080
108* AHR_22903824_ChIP-Seq_MCF-7_Human1.01399844
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.01399814
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00714633
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00197918
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00189223
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.98758231
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98753530
115PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97898864
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96518130
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95860765
118ER_23166858_ChIP-Seq_MCF-7_Human0.95054183
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.95046870
120* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93885769
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.92366874
122P53_22387025_ChIP-Seq_ESCs_Mouse0.92311853
123* JUN_21703547_ChIP-Seq_K562_Human0.92179175
124* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91519547
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90979852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.81230683
2MP0003880_abnormal_central_pattern5.09408667
3* MP0003635_abnormal_synaptic_transmissio4.07209057
4MP0004270_analgesia3.58584329
5* MP0009745_abnormal_behavioral_response3.47882691
6MP0002063_abnormal_learning/memory/cond3.26985438
7MP0009046_muscle_twitch3.08681115
8* MP0002064_seizures3.08545894
9MP0001968_abnormal_touch/_nociception2.92736671
10MP0002572_abnormal_emotion/affect_behav2.92440492
11MP0002735_abnormal_chemical_nociception2.73463284
12MP0005423_abnormal_somatic_nervous2.57135424
13MP0002272_abnormal_nervous_system2.54378644
14MP0003787_abnormal_imprinting2.48163842
15MP0001501_abnormal_sleep_pattern2.43765187
16MP0002734_abnormal_mechanical_nocicepti2.39448880
17MP0001486_abnormal_startle_reflex2.39264265
18MP0003195_calcinosis2.35774729
19MP0002736_abnormal_nociception_after2.32557731
20MP0001440_abnormal_grooming_behavior2.21376010
21* MP0002067_abnormal_sensory_capabilities1.94508531
22MP0002822_catalepsy1.91511669
23MP0003879_abnormal_hair_cell1.88130726
24MP0002733_abnormal_thermal_nociception1.86722077
25MP0001970_abnormal_pain_threshold1.80109709
26MP0001188_hyperpigmentation1.79210786
27MP0009780_abnormal_chondrocyte_physiolo1.71447567
28MP0001502_abnormal_circadian_rhythm1.69504458
29MP0005645_abnormal_hypothalamus_physiol1.68590599
30MP0006276_abnormal_autonomic_nervous1.67939299
31MP0002184_abnormal_innervation1.67887118
32MP0005646_abnormal_pituitary_gland1.66018856
33MP0000778_abnormal_nervous_system1.64964639
34* MP0002557_abnormal_social/conspecific_i1.63006576
35MP0003122_maternal_imprinting1.60570352
36MP0004924_abnormal_behavior1.56147882
37MP0005386_behavior/neurological_phenoty1.56147882
38MP0004133_heterotaxia1.55320456
39* MP0008569_lethality_at_weaning1.51898887
40MP0002163_abnormal_gland_morphology1.48244334
41MP0002909_abnormal_adrenal_gland1.47708055
42MP0003878_abnormal_ear_physiology1.47214580
43MP0005377_hearing/vestibular/ear_phenot1.47214580
44MP0005171_absent_coat_pigmentation1.46119364
45* MP0001905_abnormal_dopamine_level1.45821890
46MP0004811_abnormal_neuron_physiology1.45563242
47MP0004858_abnormal_nervous_system1.44006706
48MP0001944_abnormal_pancreas_morphology1.39151310
49MP0003633_abnormal_nervous_system1.33690957
50* MP0002882_abnormal_neuron_morphology1.31270741
51MP0002693_abnormal_pancreas_physiology1.29762725
52* MP0002066_abnormal_motor_capabilities/c1.28979395
53MP0000955_abnormal_spinal_cord1.28796580
54MP0001984_abnormal_olfaction1.27297879
55MP0005253_abnormal_eye_physiology1.26201686
56MP0003329_amyloid_beta_deposits1.19730296
57MP0002928_abnormal_bile_duct1.16052937
58MP0002876_abnormal_thyroid_physiology1.13333614
59MP0004885_abnormal_endolymph1.11909168
60MP0008961_abnormal_basal_metabolism1.08294926
61MP0003183_abnormal_peptide_metabolism1.07301170
62* MP0004142_abnormal_muscle_tone1.07059991
63MP0003646_muscle_fatigue1.06544270
64MP0005409_darkened_coat_color1.05968360
65MP0004145_abnormal_muscle_electrophysio1.05088819
66MP0010386_abnormal_urinary_bladder1.04826070
67* MP0003698_abnormal_male_reproductive1.01969842
68* MP0003631_nervous_system_phenotype1.00901093
69MP0000427_abnormal_hair_cycle0.99788509
70MP0005551_abnormal_eye_electrophysiolog0.99353805
71MP0001529_abnormal_vocalization0.98104258
72MP0008877_abnormal_DNA_methylation0.97231294
73MP0004147_increased_porphyrin_level0.96931711
74* MP0002152_abnormal_brain_morphology0.96004100
75MP0005448_abnormal_energy_balance0.94092325
76MP0000569_abnormal_digit_pigmentation0.93911599
77MP0001963_abnormal_hearing_physiology0.93404263
78MP0000230_abnormal_systemic_arterial0.93400008
79MP0001986_abnormal_taste_sensitivity0.93037706
80MP0002638_abnormal_pupillary_reflex0.92753271
81MP0000751_myopathy0.91267406
82MP0002078_abnormal_glucose_homeostasis0.91059779
83MP0008875_abnormal_xenobiotic_pharmacok0.90098947
84MP0002229_neurodegeneration0.90089221
85MP0003011_delayed_dark_adaptation0.88272051
86MP0002837_dystrophic_cardiac_calcinosis0.86803715
87MP0002938_white_spotting0.86632247
88* MP0002069_abnormal_eating/drinking_beha0.85988526
89MP0000013_abnormal_adipose_tissue0.85086214
90* MP0003953_abnormal_hormone_level0.84947411
91MP0003137_abnormal_impulse_conducting0.84763893
92MP0010329_abnormal_lipoprotein_level0.84421940
93MP0002102_abnormal_ear_morphology0.83467738
94MP0005174_abnormal_tail_pigmentation0.82798112
95MP0005195_abnormal_posterior_eye0.81425819
96MP0001485_abnormal_pinna_reflex0.81385349
97MP0004085_abnormal_heartbeat0.81197992
98MP0008872_abnormal_physiological_respon0.81193226
99MP0006292_abnormal_olfactory_placode0.80830842
100MP0005535_abnormal_body_temperature0.80041351
101MP0005220_abnormal_exocrine_pancreas0.79013644
102MP0005410_abnormal_fertilization0.78807098
103MP0004742_abnormal_vestibular_system0.78542341
104MP0002234_abnormal_pharynx_morphology0.76437920
105MP0004043_abnormal_pH_regulation0.76114556
106MP0006072_abnormal_retinal_apoptosis0.74687709
107MP0000631_abnormal_neuroendocrine_gland0.74195838
108* MP0001765_abnormal_ion_homeostasis0.73303098
109MP0000015_abnormal_ear_pigmentation0.72300551
110MP0003075_altered_response_to0.71879385
111MP0001664_abnormal_digestion0.71360587
112MP0003123_paternal_imprinting0.70599568
113MP0008874_decreased_physiological_sensi0.69944474
114MP0002752_abnormal_somatic_nervous0.67853270
115MP0003121_genomic_imprinting0.67349134
116MP0005379_endocrine/exocrine_gland_phen0.64513419
117MP0000678_abnormal_parathyroid_gland0.64143540
118MP0001177_atelectasis0.64063863
119MP0000026_abnormal_inner_ear0.61985153
120MP0004484_altered_response_of0.60301584
121MP0004215_abnormal_myocardial_fiber0.59768826
122MP0003634_abnormal_glial_cell0.58898465
123MP0003690_abnormal_glial_cell0.57425030
124MP0003283_abnormal_digestive_organ0.56858919
125MP0003172_abnormal_lysosome_physiology0.55336643
126MP0004510_myositis0.54709039

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.85421800
2Focal seizures (HP:0007359)5.92339811
3Myokymia (HP:0002411)5.66522646
4Epileptic encephalopathy (HP:0200134)5.53459139
5Progressive cerebellar ataxia (HP:0002073)5.15936485
6Febrile seizures (HP:0002373)4.80472134
7Visual hallucinations (HP:0002367)4.76064870
8Atonic seizures (HP:0010819)4.68466787
9Decreased circulating renin level (HP:0003351)4.32796905
10Congenital stationary night blindness (HP:0007642)4.31936651
11Dialeptic seizures (HP:0011146)4.14377108
12Generalized tonic-clonic seizures (HP:0002069)4.02078379
13Absence seizures (HP:0002121)3.99835368
14Gaze-evoked nystagmus (HP:0000640)3.89849867
15Hyperventilation (HP:0002883)3.66287255
16Amblyopia (HP:0000646)3.60489163
17Broad-based gait (HP:0002136)3.52808176
18Increased circulating renin level (HP:0000848)3.46696590
19Nephronophthisis (HP:0000090)3.41757321
20Action tremor (HP:0002345)3.39586709
21Pancreatic cysts (HP:0001737)3.28767512
22Dysmetria (HP:0001310)3.21725444
23Genetic anticipation (HP:0003743)3.21314953
24Pancreatic fibrosis (HP:0100732)3.20554435
25Abnormality of midbrain morphology (HP:0002418)3.16711583
26Molar tooth sign on MRI (HP:0002419)3.16711583
27Large for gestational age (HP:0001520)3.15570245
28Epileptiform EEG discharges (HP:0011182)3.12685929
29Dysdiadochokinesis (HP:0002075)3.09292414
30Hyperkalemia (HP:0002153)3.05208888
31True hermaphroditism (HP:0010459)3.04712354
32Hyperactive renin-angiotensin system (HP:0000841)3.04306216
33Attenuation of retinal blood vessels (HP:0007843)3.03870960
34Abnormality of the lower motor neuron (HP:0002366)3.02279620
35Abnormality of the renal medulla (HP:0100957)2.94358346
36Truncal ataxia (HP:0002078)2.94293836
37Abnormal rod and cone electroretinograms (HP:0008323)2.93777622
38Impaired vibration sensation in the lower limbs (HP:0002166)2.86754378
39Impaired smooth pursuit (HP:0007772)2.84428881
40Drooling (HP:0002307)2.79252432
41Excessive salivation (HP:0003781)2.79252432
42Hemiparesis (HP:0001269)2.75486217
43Hypothermia (HP:0002045)2.73768692
44Abnormality of the renal cortex (HP:0011035)2.69237798
45Depression (HP:0000716)2.68743055
46Severe visual impairment (HP:0001141)2.68266006
47Polydipsia (HP:0001959)2.66329806
48Abnormal drinking behavior (HP:0030082)2.66329806
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.65522057
50Absent/shortened dynein arms (HP:0200106)2.65522057
51EEG with generalized epileptiform discharges (HP:0011198)2.65113759
52Medial flaring of the eyebrow (HP:0010747)2.63042977
53Anxiety (HP:0000739)2.60793675
54Supranuclear gaze palsy (HP:0000605)2.56919978
55Bony spicule pigmentary retinopathy (HP:0007737)2.56322257
56Limb dystonia (HP:0002451)2.53128854
57Ankle clonus (HP:0011448)2.48709731
58Abnormality of ocular smooth pursuit (HP:0000617)2.48178263
59Poor eye contact (HP:0000817)2.46932458
60Chronic hepatic failure (HP:0100626)2.46572201
61Congenital sensorineural hearing impairment (HP:0008527)2.43775684
62Scanning speech (HP:0002168)2.43295673
63Blue irides (HP:0000635)2.42764000
64Hypsarrhythmia (HP:0002521)2.40698679
65Diplopia (HP:0000651)2.38986875
66Abnormality of binocular vision (HP:0011514)2.38986875
67Abnormality of macular pigmentation (HP:0008002)2.38326141
68Abnormal eating behavior (HP:0100738)2.38308462
69Protruding tongue (HP:0010808)2.38008300
70Postural instability (HP:0002172)2.37105003
71Gait imbalance (HP:0002141)2.36888910
72Cystic liver disease (HP:0006706)2.36744844
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.35397897
74Hypoplasia of the fovea (HP:0007750)2.35397897
75Agitation (HP:0000713)2.34022487
76Urinary bladder sphincter dysfunction (HP:0002839)2.33450675
77Absent speech (HP:0001344)2.31763861
78Tubular atrophy (HP:0000092)2.29821004
79Ketoacidosis (HP:0001993)2.28434903
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28349458
81Intestinal atresia (HP:0011100)2.26833937
82Polyphagia (HP:0002591)2.26488184
83Sclerocornea (HP:0000647)2.26047735
84Stereotypic behavior (HP:0000733)2.23023210
85Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.22276032
86Impaired social interactions (HP:0000735)2.21050302
87Abnormal social behavior (HP:0012433)2.21050302
88Abnormality of renin-angiotensin system (HP:0000847)2.20042669
89Bradykinesia (HP:0002067)2.16345825
90Hypoplastic ischia (HP:0003175)2.16135388
91Hemiplegia (HP:0002301)2.15385885
92Dysmetric saccades (HP:0000641)2.14140337
93Abnormality of calcium-phosphate metabolism (HP:0100530)2.13566279
94Decreased central vision (HP:0007663)2.12816063
95Abolished electroretinogram (ERG) (HP:0000550)2.10146152
96Abnormal ciliary motility (HP:0012262)2.09446732
97Retinal dysplasia (HP:0007973)2.06877980
98Pheochromocytoma (HP:0002666)2.05469567
99Spastic gait (HP:0002064)2.05193310
100Cerebellar dysplasia (HP:0007033)2.04811063
101Impaired vibratory sensation (HP:0002495)2.04601492
102Hyperaldosteronism (HP:0000859)2.04520093
103Polyuria (HP:0000103)2.03570863
104Congenital primary aphakia (HP:0007707)2.02855773
105Prolonged QT interval (HP:0001657)2.01935393
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00202784
107Status epilepticus (HP:0002133)1.99290327
108Severe muscular hypotonia (HP:0006829)1.96947917
109Lissencephaly (HP:0001339)1.95684999
110Fetal akinesia sequence (HP:0001989)1.95295325
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.94481566
112Tubulointerstitial nephritis (HP:0001970)1.93883903
113Abnormal respiratory epithelium morphology (HP:0012253)1.93812581
114Abnormal respiratory motile cilium morphology (HP:0005938)1.93812581
115Incomplete penetrance (HP:0003829)1.92793478
116Ketosis (HP:0001946)1.91674874
117Urinary urgency (HP:0000012)1.91035138
118Furrowed tongue (HP:0000221)1.90367816
119Abnormality of salivation (HP:0100755)1.88848169
120Type II lissencephaly (HP:0007260)1.88676760
121Abnormal respiratory motile cilium physiology (HP:0012261)1.86433345
122Dyskinesia (HP:0100660)1.84457136
123Generalized myoclonic seizures (HP:0002123)1.83915587
124Pachygyria (HP:0001302)1.83598350
125Renal cortical cysts (HP:0000803)1.83449307
126Genital tract atresia (HP:0001827)1.83218063
127Clumsiness (HP:0002312)1.82235490
128Abnormality of the ischium (HP:0003174)1.81740588
129Abnormality of the fovea (HP:0000493)1.81300944
130Keratoconus (HP:0000563)1.80428098
131Increased corneal curvature (HP:0100692)1.80428098
132Congenital hepatic fibrosis (HP:0002612)1.80311157
133Abnormality of saccadic eye movements (HP:0000570)1.80017446
134Gait ataxia (HP:0002066)1.79512527
135Nephrogenic diabetes insipidus (HP:0009806)1.78917712
136Intention tremor (HP:0002080)1.78618101
137Progressive inability to walk (HP:0002505)1.77769455
138Toxemia of pregnancy (HP:0100603)1.77537045
139Widely spaced teeth (HP:0000687)1.74967306
140Focal dystonia (HP:0004373)1.74514480
141Optic nerve hypoplasia (HP:0000609)1.74090450
142Lower limb amyotrophy (HP:0007210)1.73673226
143Vaginal atresia (HP:0000148)1.72764054
144Thickened helices (HP:0000391)1.71858840
145Confusion (HP:0001289)1.70945212
146Neuroendocrine neoplasm (HP:0100634)1.70287392
147Bradycardia (HP:0001662)1.70065447
148Torticollis (HP:0000473)1.69913032
149Hypoventilation (HP:0002791)1.69713536
150Ventricular fibrillation (HP:0001663)1.69657481
151Psychosis (HP:0000709)1.69633988
152Mutism (HP:0002300)1.69209390
153Inability to walk (HP:0002540)1.68724360
154Generalized hypopigmentation of hair (HP:0011358)1.67727662
155Lower limb muscle weakness (HP:0007340)1.66323767
156Cerebral inclusion bodies (HP:0100314)1.66216871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.23437044
2NTRK36.23628656
3EPHA44.23897012
4MAP3K93.09971771
5TNIK3.01339093
6MAP3K43.00910723
7MAP2K72.88563765
8CASK2.68264056
9ACVR1B2.12441718
10DAPK22.08475661
11BMPR1B2.07419252
12MINK12.05795986
13MARK12.03065864
14GRK12.01456945
15PRPF4B2.00527752
16MAP4K21.99653647
17PRKD31.96152609
18NTRK21.92727814
19DAPK11.82632879
20MAP2K41.77968617
21PAK61.64956049
22MAPK131.59058786
23MAP3K121.58280124
24PLK21.55360716
25TLK11.54748528
26KSR11.45824850
27RIPK41.45762924
28CAMK2B1.43818186
29CDK191.39048454
30MAP3K131.38627118
31CDK51.37488571
32CAMK2A1.34596978
33FGFR21.33287125
34KSR21.29289351
35FES1.24926060
36ZAK1.24576021
37GRK51.22694198
38PTK2B1.22558102
39PRKCG1.22295386
40MARK21.21678980
41CAMKK11.15705694
42NTRK11.14895045
43UHMK11.13082887
44AKT31.11271843
45SIK21.10750451
46STK381.09971627
47CSNK1G21.08637157
48MAPK151.08046295
49MKNK21.07820282
50CAMK11.07205766
51INSRR1.05077561
52PNCK1.04596741
53WNK31.04496503
54NME10.99977739
55CAMKK20.98812622
56MAP3K20.96962674
57MUSK0.96495308
58SGK2230.95978799
59SGK4940.95978799
60SGK20.95453387
61ADRBK10.94068122
62ARAF0.92051062
63STK390.90336786
64TAOK30.87569201
65CDC42BPA0.84782972
66STK38L0.84351808
67SGK10.83782935
68MAP2K60.83594189
69CAMK2D0.79381586
70OXSR10.78984042
71DYRK20.78040063
72PAK30.77267148
73BMPR20.77049232
74DYRK1A0.74593155
75CDK180.74273133
76CDK150.72362233
77MAPKAPK50.71530328
78FER0.69585802
79CAMK1D0.69568281
80PRKAA10.69445487
81WNK40.68943956
82MAPKAPK30.65779289
83PRKCH0.65429128
84TNK20.65346950
85CDK140.64469046
86CDK11A0.64423603
87MAP3K70.63941761
88PKN10.63179134
89SGK30.63156411
90PRKCE0.63091174
91PDK10.61251409
92CAMK2G0.59868704
93NEK60.59845244
94CSNK1G10.59335030
95MAP3K60.58888431
96STK110.58396335
97PRKAA20.58276065
98PRKCZ0.57473640
99CSNK1G30.56484666
100SIK30.56418847
101BRAF0.52888326
102RET0.51562017
103NUAK10.48939751
104PDPK10.48496373
105PINK10.47815467
106FGR0.46821883
107CAMK40.46704615
108RAF10.45974475
109RPS6KA30.45551220
110CAMK1G0.43370120
111DMPK0.41757262
112TRPM70.41056457
113PRKG10.40813237
114PHKG20.40254104
115PHKG10.40254104
116WNK10.40019270
117ADRBK20.39866492
118CSNK1D0.38430717
119MAP3K10.38167995
120STK30.37619642
121PRKCA0.37280325
122PTK20.36806440
123CDK30.36549386
124FYN0.36191660
125PRKACA0.34468612
126TYRO30.34468153
127PRKACB0.33414895
128CSNK1A1L0.32892306
129CSNK1A10.32608058
130PRKCB0.32360891
131CSNK1E0.32297825
132CCNB10.32093490
133ERBB30.31778292
134CHUK0.28933526
135TIE10.27017839
136GSK3B0.26355047
137MAP2K10.25960373

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.40575863
2Synaptic vesicle cycle_Homo sapiens_hsa047213.28977658
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.16758700
4* Circadian entrainment_Homo sapiens_hsa047133.08161883
5Amphetamine addiction_Homo sapiens_hsa050312.97175268
6Long-term potentiation_Homo sapiens_hsa047202.91050787
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90604242
8Glutamatergic synapse_Homo sapiens_hsa047242.89152602
9* GABAergic synapse_Homo sapiens_hsa047272.52842048
10Butanoate metabolism_Homo sapiens_hsa006502.51896008
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43886004
12* Morphine addiction_Homo sapiens_hsa050322.42187405
13Insulin secretion_Homo sapiens_hsa049112.36603276
14Olfactory transduction_Homo sapiens_hsa047402.32842490
15Salivary secretion_Homo sapiens_hsa049702.19127486
16* Dopaminergic synapse_Homo sapiens_hsa047282.17657815
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07837145
18Cocaine addiction_Homo sapiens_hsa050302.05313885
19Taste transduction_Homo sapiens_hsa047422.04360240
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99378874
21Selenocompound metabolism_Homo sapiens_hsa004501.92932468
22Long-term depression_Homo sapiens_hsa047301.89355782
23* Serotonergic synapse_Homo sapiens_hsa047261.87517440
24Calcium signaling pathway_Homo sapiens_hsa040201.84285399
25* Cholinergic synapse_Homo sapiens_hsa047251.78624353
26Linoleic acid metabolism_Homo sapiens_hsa005911.70057098
27Collecting duct acid secretion_Homo sapiens_hsa049661.66977754
28Renin secretion_Homo sapiens_hsa049241.65766270
29Gastric acid secretion_Homo sapiens_hsa049711.65561397
30* Oxytocin signaling pathway_Homo sapiens_hsa049211.65046715
31Tryptophan metabolism_Homo sapiens_hsa003801.61058126
32Type II diabetes mellitus_Homo sapiens_hsa049301.49643859
33Nitrogen metabolism_Homo sapiens_hsa009101.49236911
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48702410
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48419531
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47721620
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46488938
38cAMP signaling pathway_Homo sapiens_hsa040241.43374313
39GnRH signaling pathway_Homo sapiens_hsa049121.39821430
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39038733
41Ether lipid metabolism_Homo sapiens_hsa005651.36757210
42ABC transporters_Homo sapiens_hsa020101.24314457
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24189261
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19326472
45Vibrio cholerae infection_Homo sapiens_hsa051101.16798228
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16591260
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15956904
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14002193
49Axon guidance_Homo sapiens_hsa043601.13773070
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.12888222
51Circadian rhythm_Homo sapiens_hsa047101.09396640
52Gap junction_Homo sapiens_hsa045401.09327973
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03597325
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01229055
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97106146
56Fatty acid biosynthesis_Homo sapiens_hsa000610.97086963
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.96765549
58Cardiac muscle contraction_Homo sapiens_hsa042600.96701236
59* Estrogen signaling pathway_Homo sapiens_hsa049150.94728362
60Pancreatic secretion_Homo sapiens_hsa049720.92980453
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92962086
62Melanogenesis_Homo sapiens_hsa049160.89567034
63ErbB signaling pathway_Homo sapiens_hsa040120.88675631
64Thyroid hormone synthesis_Homo sapiens_hsa049180.87400313
65Phototransduction_Homo sapiens_hsa047440.85006082
66Glioma_Homo sapiens_hsa052140.84557606
67Protein export_Homo sapiens_hsa030600.82228272
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78667434
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.77645243
70Dilated cardiomyopathy_Homo sapiens_hsa054140.74560295
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74460321
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.72974099
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72496523
74Choline metabolism in cancer_Homo sapiens_hsa052310.72050078
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71877146
76Histidine metabolism_Homo sapiens_hsa003400.71829539
77Retinol metabolism_Homo sapiens_hsa008300.70862261
78MAPK signaling pathway_Homo sapiens_hsa040100.68915233
79Regulation of autophagy_Homo sapiens_hsa041400.68900330
80beta-Alanine metabolism_Homo sapiens_hsa004100.68674294
81Glucagon signaling pathway_Homo sapiens_hsa049220.68056778
82Vitamin B6 metabolism_Homo sapiens_hsa007500.67837937
83Caffeine metabolism_Homo sapiens_hsa002320.67186332
84Dorso-ventral axis formation_Homo sapiens_hsa043200.66983480
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65237067
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64687114
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62849945
88Peroxisome_Homo sapiens_hsa041460.59992228
89Ras signaling pathway_Homo sapiens_hsa040140.59360153
90Inositol phosphate metabolism_Homo sapiens_hsa005620.58548146
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56932821
92Lysine degradation_Homo sapiens_hsa003100.56414638
93Oocyte meiosis_Homo sapiens_hsa041140.56059833
94Chemical carcinogenesis_Homo sapiens_hsa052040.55046772
95Glycerolipid metabolism_Homo sapiens_hsa005610.52900145
96Parkinsons disease_Homo sapiens_hsa050120.51977616
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50508091
98Ovarian steroidogenesis_Homo sapiens_hsa049130.50144542
99Arachidonic acid metabolism_Homo sapiens_hsa005900.47845156
100Alzheimers disease_Homo sapiens_hsa050100.47799817
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47552283
102Rap1 signaling pathway_Homo sapiens_hsa040150.46064467
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45779978
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45600989
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45539015
106Propanoate metabolism_Homo sapiens_hsa006400.45209502
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44048651
108Alcoholism_Homo sapiens_hsa050340.42744593
109African trypanosomiasis_Homo sapiens_hsa051430.42676135
110Sphingolipid metabolism_Homo sapiens_hsa006000.41627563
111Wnt signaling pathway_Homo sapiens_hsa043100.39741443
112VEGF signaling pathway_Homo sapiens_hsa043700.38995422
113Huntingtons disease_Homo sapiens_hsa050160.38833843
114Type I diabetes mellitus_Homo sapiens_hsa049400.38117138
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37637490
116Bile secretion_Homo sapiens_hsa049760.35596009
117Prion diseases_Homo sapiens_hsa050200.34784593
118Folate biosynthesis_Homo sapiens_hsa007900.34026477
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32860183
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32521841
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.32370942
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.30885580
123Rheumatoid arthritis_Homo sapiens_hsa053230.30232664
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29597155
125Oxidative phosphorylation_Homo sapiens_hsa001900.29477135
126Mineral absorption_Homo sapiens_hsa049780.26633807
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25736069
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.25093193
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24057133
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22269295
131Endocytosis_Homo sapiens_hsa041440.21045258
132Insulin signaling pathway_Homo sapiens_hsa049100.19898093
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19468301
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18801684
135mTOR signaling pathway_Homo sapiens_hsa041500.17502669
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17326571
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15688572
138Chemokine signaling pathway_Homo sapiens_hsa040620.14599874

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