KCNJ8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)9.17791101
2vascular endothelial growth factor signaling pathway (GO:0038084)7.87523355
3lymphangiogenesis (GO:0001946)6.83982992
4cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.16222559
5endothelium development (GO:0003158)5.04800999
6L-phenylalanine catabolic process (GO:0006559)5.02662080
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.02662080
8cardiac myofibril assembly (GO:0055003)4.97634804
9positive regulation of protein kinase C signaling (GO:0090037)4.64035262
10L-phenylalanine metabolic process (GO:0006558)4.56484724
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.56484724
12artery smooth muscle contraction (GO:0014824)4.50939266
13vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.44934341
14retina vasculature morphogenesis in camera-type eye (GO:0061299)4.39840207
15heart trabecula formation (GO:0060347)4.35045838
16transcytosis (GO:0045056)4.34294402
17interleukin-6-mediated signaling pathway (GO:0070102)4.23438635
18myofibril assembly (GO:0030239)4.22807942
19tonic smooth muscle contraction (GO:0014820)4.22554803
20sarcomere organization (GO:0045214)4.17550512
21cell migration involved in heart development (GO:0060973)4.11491466
22positive regulation of astrocyte differentiation (GO:0048711)3.99670839
23regulation of protein activation cascade (GO:2000257)3.79446382
24exogenous drug catabolic process (GO:0042738)3.79413504
25epoxygenase P450 pathway (GO:0019373)3.72945951
26regulation of cholesterol esterification (GO:0010872)3.72445119
27atrioventricular valve morphogenesis (GO:0003181)3.70299156
28complement activation, alternative pathway (GO:0006957)3.70074753
29drug catabolic process (GO:0042737)3.69858522
30negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.68185949
31ethanol oxidation (GO:0006069)3.63971487
32regulation of sequestering of triglyceride (GO:0010889)3.62483030
33regulation of complement activation (GO:0030449)3.61179684
34glyoxylate metabolic process (GO:0046487)3.59346626
35glomerular filtration (GO:0003094)3.58825300
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.57001460
37positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.53734868
38omega-hydroxylase P450 pathway (GO:0097267)3.52215402
39protein heterotrimerization (GO:0070208)3.50545253
40plasma membrane repair (GO:0001778)3.44413752
41carnitine shuttle (GO:0006853)3.44087663
42fatty acid transmembrane transport (GO:1902001)3.43782101
43cellular ketone body metabolic process (GO:0046950)3.42805496
44* potassium ion import (GO:0010107)3.40215647
45vascular smooth muscle contraction (GO:0014829)3.40175320
46aromatic amino acid family catabolic process (GO:0009074)3.36426147
47blood vessel endothelial cell migration (GO:0043534)3.35750012
48actin-myosin filament sliding (GO:0033275)3.35744893
49muscle filament sliding (GO:0030049)3.35744893
50regulation of actin filament-based movement (GO:1903115)3.34925670
51leukocyte tethering or rolling (GO:0050901)3.34786609
52negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34045222
53positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.32027722
54regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.30307447
55blood coagulation, intrinsic pathway (GO:0007597)3.27746584
56positive regulation of vasculogenesis (GO:2001214)3.25467452
57regulation of fibrinolysis (GO:0051917)3.25302683
58regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.25100160
59triglyceride homeostasis (GO:0070328)3.23609418
60acylglycerol homeostasis (GO:0055090)3.23609418
61xenobiotic catabolic process (GO:0042178)3.22497901
62positive regulation of fatty acid oxidation (GO:0046321)3.21555949
63patterning of blood vessels (GO:0001569)3.21158880
64cGMP-mediated signaling (GO:0019934)3.19094374
65tricarboxylic acid cycle (GO:0006099)3.16791317
66triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15066281
67endocardial cushion morphogenesis (GO:0003203)3.14303739
68renal filtration (GO:0097205)3.14168801
69negative regulation of potassium ion transmembrane transport (GO:1901380)3.13515929
70ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.13468959
71sprouting angiogenesis (GO:0002040)3.12163057
72cell migration involved in sprouting angiogenesis (GO:0002042)3.12132487
73regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11050798
74regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.08715790
75positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.08467953
76positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.07961980
77relaxation of smooth muscle (GO:0044557)3.07653852
78peptidyl-glutamic acid carboxylation (GO:0017187)3.05648096
79protein carboxylation (GO:0018214)3.05648096
80plasma lipoprotein particle remodeling (GO:0034369)3.05072507
81protein-lipid complex remodeling (GO:0034368)3.05072507
82macromolecular complex remodeling (GO:0034367)3.05072507
83trabecula formation (GO:0060343)3.04639675
84cardiac muscle tissue morphogenesis (GO:0055008)3.02278842
85cardiac muscle contraction (GO:0060048)3.01865371
86positive regulation of smooth muscle cell migration (GO:0014911)3.01219425
87drug metabolic process (GO:0017144)2.98982318
88bile acid biosynthetic process (GO:0006699)2.98860751
89negative regulation of protein activation cascade (GO:2000258)2.98343555
90phenylpropanoid metabolic process (GO:0009698)2.97689236
91bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97583350
92regulation of fatty acid oxidation (GO:0046320)2.97188530
93surfactant homeostasis (GO:0043129)2.97134549
94actomyosin structure organization (GO:0031032)2.96945028
95cardiac muscle cell development (GO:0055013)2.96789315
96ketone body metabolic process (GO:1902224)2.95667790
97regulation of skeletal muscle contraction (GO:0014819)2.95602140
98regulation of phospholipase A2 activity (GO:0032429)2.95566153
99cardiac muscle cell proliferation (GO:0060038)2.95464763
100endothelial cell differentiation (GO:0045446)2.95450354
101regulation of vasculogenesis (GO:2001212)2.94796267
102sexual reproduction (GO:0019953)2.93660097
103basement membrane organization (GO:0071711)2.93346083
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87221710
105regulation of endothelial cell differentiation (GO:0045601)2.85504208
106muscle tissue morphogenesis (GO:0060415)2.85318314
107negative regulation of blood vessel endothelial cell migration (GO:0043537)2.83713137
108cardiac cell development (GO:0055006)2.83702936
109regulation of lipoprotein metabolic process (GO:0050746)2.83518527
110oxidative demethylation (GO:0070989)2.82627013
111actin-mediated cell contraction (GO:0070252)2.82262870
112regulation of relaxation of muscle (GO:1901077)2.82212216
113positive regulation of cardiac muscle hypertrophy (GO:0010613)2.81110196
114positive regulation of muscle hypertrophy (GO:0014742)2.81110196
115lysine catabolic process (GO:0006554)2.77708469
116lysine metabolic process (GO:0006553)2.77708469
117mesenchyme morphogenesis (GO:0072132)2.76427941
118regulation of triglyceride catabolic process (GO:0010896)2.76127611
119striated muscle hypertrophy (GO:0014897)2.76055035
120fatty acid beta-oxidation (GO:0006635)2.74514611
121substrate-dependent cell migration (GO:0006929)2.73094949
122detection of calcium ion (GO:0005513)2.72486066
1232-oxoglutarate metabolic process (GO:0006103)2.70811601
124ethanol metabolic process (GO:0006067)2.70691140
125endothelial tube morphogenesis (GO:0061154)2.69371263
126morphogenesis of an endothelium (GO:0003159)2.69371263
127embryonic heart tube development (GO:0035050)2.68933025
128positive regulation vascular endothelial growth factor production (GO:0010575)2.68777761
129regulation of cardiac muscle cell contraction (GO:0086004)2.68641651
130negative regulation of fibrinolysis (GO:0051918)2.68156559
131gap junction assembly (GO:0016264)2.68062339
132cellular glucuronidation (GO:0052695)2.67738643
133negative regulation of complement activation (GO:0045916)2.66850291
134venous blood vessel morphogenesis (GO:0048845)2.66303180
135mesenchymal cell development (GO:0014031)2.65330012
136muscle cell proliferation (GO:0033002)2.64478619
137negative regulation of endothelial cell migration (GO:0010596)2.64331175
138negative regulation of platelet activation (GO:0010544)2.63901365
139positive regulation of endothelial cell proliferation (GO:0001938)2.62399049
140ventricular cardiac muscle cell action potential (GO:0086005)2.61667575
141cell proliferation involved in metanephros development (GO:0072203)2.61276062
142regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61203161
143high-density lipoprotein particle remodeling (GO:0034375)2.61056653
144relaxation of muscle (GO:0090075)2.59803458
145serine family amino acid catabolic process (GO:0009071)2.59087637
146regulation of cell communication by electrical coupling (GO:0010649)2.57940357
147carnitine transmembrane transport (GO:1902603)2.56656859
148creatine metabolic process (GO:0006600)2.52243460
149endothelial cell morphogenesis (GO:0001886)2.50960119
150glucuronate metabolic process (GO:0019585)2.50695200
151uronic acid metabolic process (GO:0006063)2.50695200
152negative regulation of lipase activity (GO:0060192)2.50075441
153cardiac muscle hypertrophy (GO:0003300)2.49643574
154reverse cholesterol transport (GO:0043691)2.49044040
155regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.49037499
156negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.48932221
157negative regulation of vascular permeability (GO:0043116)2.48728387
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.48609474
159fatty acid oxidation (GO:0019395)2.47991606
160negative regulation of homotypic cell-cell adhesion (GO:0034111)2.47298192
161S-adenosylmethionine metabolic process (GO:0046500)2.46910596
162phospholipid homeostasis (GO:0055091)2.46064169
163kidney mesenchyme development (GO:0072074)2.45058384
164relaxation of cardiac muscle (GO:0055119)2.44778775
165protein activation cascade (GO:0072376)2.44363656
166tyrosine metabolic process (GO:0006570)2.44260224
167regulation of lipoprotein lipase activity (GO:0051004)2.43823038
168regulation of plasminogen activation (GO:0010755)2.42501176
169cellular response to leptin stimulus (GO:0044320)2.42072883
170muscle hypertrophy (GO:0014896)2.40639750
171negative regulation of blood coagulation (GO:0030195)2.40155950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.48593821
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.96675791
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.44361812
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.58056443
5CLOCK_20551151_ChIP-Seq_293T_Human3.27656914
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.84825271
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.66320249
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.62415932
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48342314
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48274797
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.35369606
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.33583674
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.28587179
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22168784
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22080243
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.20447920
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.16835029
18TBX20_22328084_ChIP-Seq_HEART_Mouse2.15916529
19TBX20_22080862_ChIP-Seq_HEART_Mouse2.15916529
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15341143
21PIAS1_25552417_ChIP-Seq_VCAP_Human2.11718527
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11459315
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.11031085
24GBX2_23144817_ChIP-Seq_PC3_Human2.06390578
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.96215572
26VDR_22108803_ChIP-Seq_LS180_Human1.93729687
27EZH2_22144423_ChIP-Seq_EOC_Human1.84295399
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82787574
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.81738226
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80961622
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73985054
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72238066
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70435356
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70292663
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67222152
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66492541
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65642198
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61671108
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60519403
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60048308
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60048308
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60048308
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57228998
44* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55462869
45* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54990517
46AR_21572438_ChIP-Seq_LNCaP_Human1.54394478
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52916333
48TAF15_26573619_Chip-Seq_HEK293_Human1.51477913
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51011691
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.49596307
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.49265960
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48257273
53ZNF263_19887448_ChIP-Seq_K562_Human1.48115167
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45014215
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.43844309
56IGF1R_20145208_ChIP-Seq_DFB_Human1.38564537
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37951083
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37177386
59* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36298021
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35226694
61DROSHA_22980978_ChIP-Seq_HELA_Human1.34418780
62CJUN_26792858_Chip-Seq_BT549_Human1.33978861
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.31608411
64BCAT_22108803_ChIP-Seq_LS180_Human1.30192533
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28432527
66GATA1_19941826_ChIP-Seq_K562_Human1.27192664
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27022957
68* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26807356
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.25516039
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25490938
71RNF2_27304074_Chip-Seq_NSC_Mouse1.23769885
72* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23563835
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22358852
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22061319
75FUS_26573619_Chip-Seq_HEK293_Human1.21987964
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21231809
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21231809
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19366399
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17461415
80LXR_22292898_ChIP-Seq_THP-1_Human1.17384812
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15912897
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.15423346
83SMAD4_21799915_ChIP-Seq_A2780_Human1.14508553
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14161847
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.13973803
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13173515
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12696474
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.12342504
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11091253
90HTT_18923047_ChIP-ChIP_STHdh_Human1.11006155
91AR_25329375_ChIP-Seq_VCAP_Human1.10140452
92* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07204014
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07202534
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04009871
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03848348
96P300_19829295_ChIP-Seq_ESCs_Human1.03408553
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03208525
98ER_23166858_ChIP-Seq_MCF-7_Human1.03047776
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02204821
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01043144
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00657300
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00618361
103TBL1_22424771_ChIP-Seq_293T_Human0.99823165
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99406744
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99395212
106* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99183808
107* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99124240
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98634791
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98102484
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98102484
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97979427
112* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97816952
113SOX2_20726797_ChIP-Seq_SW620_Human0.97140148
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.96728166
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96018202
116* CBP_21632823_ChIP-Seq_H3396_Human0.94963774
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.94448321
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93877387
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.93267097
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92915122
121MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92743155
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92375528
123SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92351234
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91973348
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91789848
126EZH2_27294783_Chip-Seq_ESCs_Mouse0.90778720
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90750691
128* NFYA_21822215_ChIP-Seq_K562_Human0.90612142
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90005307
130* RACK7_27058665_Chip-Seq_MCF-7_Human0.89761683
131TCF4_18268006_ChIP-ChIP_LS174T_Human0.89737274
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89348517
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.89166642
134* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88653526
135SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87781731
136CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87748747
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87736130
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87485647
139FOXA2_19822575_ChIP-Seq_HepG2_Human0.87386655
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87271095
141FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86721197
142* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86084723
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85177882
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84355776
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84320193
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.83564335
147EZH2_27304074_Chip-Seq_ESCs_Mouse0.82693726
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82656575
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82351979
150KDM2B_26808549_Chip-Seq_DND41_Human0.82217625
151* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81383125
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80630444
153RING1B_27294783_Chip-Seq_ESCs_Mouse0.80256938
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79977411
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79643844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.10079533
2MP0006054_spinal_hemorrhage4.95392109
3MP0001879_abnormal_lymphatic_vessel4.82064845
4MP0003724_increased_susceptibility_to4.04946825
5MP0000013_abnormal_adipose_tissue3.85720619
6MP0002139_abnormal_hepatobiliary_system3.84491700
7MP0003283_abnormal_digestive_organ3.46101679
8MP0002837_dystrophic_cardiac_calcinosis3.45784588
9* MP0004215_abnormal_myocardial_fiber3.12177499
10MP0004084_abnormal_cardiac_muscle3.10634494
11MP0004272_abnormal_basement_membrane2.91382136
12MP0000751_myopathy2.84505963
13MP0004130_abnormal_muscle_cell2.83577272
14MP0008004_abnormal_stomach_pH2.82978898
15MP0008438_abnormal_cutaneous_collagen2.61092689
16MP0009780_abnormal_chondrocyte_physiolo2.37769042
17MP0004036_abnormal_muscle_relaxation2.35621122
18MP0005330_cardiomyopathy2.28213455
19MP0003279_aneurysm2.16216992
20MP0003300_gastrointestinal_ulcer2.10214281
21MP0005187_abnormal_penis_morphology2.04638395
22MP0003195_calcinosis2.00861266
23MP0005670_abnormal_white_adipose1.99213305
24MP0003646_muscle_fatigue1.97513960
25MP0000003_abnormal_adipose_tissue1.95659351
26MP0003828_pulmonary_edema1.94504345
27MP0002972_abnormal_cardiac_muscle1.94140451
28MP0005620_abnormal_muscle_contractility1.93734543
29MP0008775_abnormal_heart_ventricle1.78222048
30MP0002876_abnormal_thyroid_physiology1.78214668
31MP0000749_muscle_degeneration1.77409105
32MP0003868_abnormal_feces_composition1.77265503
33MP0002638_abnormal_pupillary_reflex1.76656595
34MP0003137_abnormal_impulse_conducting1.72724742
35MP0010630_abnormal_cardiac_muscle1.67161540
36MP0005167_abnormal_blood-brain_barrier1.65627860
37MP0005385_cardiovascular_system_phenoty1.64318116
38MP0001544_abnormal_cardiovascular_syste1.64318116
39MP0004087_abnormal_muscle_fiber1.63734534
40MP0006138_congestive_heart_failure1.63239318
41MP0005332_abnormal_amino_acid1.61990527
42MP0005375_adipose_tissue_phenotype1.56586422
43MP0004484_altered_response_of1.54438435
44MP0002909_abnormal_adrenal_gland1.52468850
45MP0005666_abnormal_adipose_tissue1.51945535
46MP0008875_abnormal_xenobiotic_pharmacok1.49886247
47MP0002127_abnormal_cardiovascular_syste1.49609038
48MP0001851_eye_inflammation1.43474023
49MP0000750_abnormal_muscle_regeneration1.43337885
50MP0005165_increased_susceptibility_to1.43179348
51MP0009840_abnormal_foam_cell1.42277073
52MP0000767_abnormal_smooth_muscle1.42038378
53MP0001666_abnormal_nutrient_absorption1.36611876
54MP0003136_yellow_coat_color1.35970360
55MP0005275_abnormal_skin_tensile1.34113094
56MP0000343_altered_response_to1.33136586
57MP0005623_abnormal_meninges_morphology1.29647098
58* MP0004085_abnormal_heartbeat1.28061340
59MP0009697_abnormal_copulation1.27296455
60MP0004185_abnormal_adipocyte_glucose1.27177409
61MP0004019_abnormal_vitamin_homeostasis1.25925692
62MP0003252_abnormal_bile_duct1.25594902
63MP0005379_endocrine/exocrine_gland_phen1.25338343
64MP0002128_abnormal_blood_circulation1.25329509
65MP0005595_abnormal_vascular_smooth1.24542988
66MP0000230_abnormal_systemic_arterial1.12819155
67MP0002106_abnormal_muscle_physiology1.11433699
68MP0005164_abnormal_response_to1.11038653
69MP0004147_increased_porphyrin_level1.09417056
70MP0002118_abnormal_lipid_homeostasis1.06878636
71MP0004145_abnormal_muscle_electrophysio1.03004776
72MP0002163_abnormal_gland_morphology1.01344163
73MP0001661_extended_life_span1.01212759
74MP0005085_abnormal_gallbladder_physiolo1.00777278
75MP0001944_abnormal_pancreas_morphology1.00647912
76MP0000465_gastrointestinal_hemorrhage0.99407769
77MP0002332_abnormal_exercise_endurance0.99219076
78MP0005409_darkened_coat_color0.97891757
79MP0000462_abnormal_digestive_system0.96347166
80MP0000249_abnormal_blood_vessel0.95372129
81MP0000266_abnormal_heart_morphology0.95063024
82MP0010329_abnormal_lipoprotein_level0.94432818
83MP0002138_abnormal_hepatobiliary_system0.93699787
84MP0002269_muscular_atrophy0.93407938
85MP0005220_abnormal_exocrine_pancreas0.93233682
86MP0005369_muscle_phenotype0.92838053
87MP0005360_urolithiasis0.92788080
88MP0009384_cardiac_valve_regurgitation0.91807106
89MP0000516_abnormal_urinary_system0.91443604
90MP0005367_renal/urinary_system_phenotyp0.91443604
91MP0003566_abnormal_cell_adhesion0.91076674
92MP0000747_muscle_weakness0.91044292
93MP0003879_abnormal_hair_cell0.90937371
94MP0003705_abnormal_hypodermis_morpholog0.90555514
95MP0001614_abnormal_blood_vessel0.89593336
96MP0005646_abnormal_pituitary_gland0.88672810
97MP0001958_emphysema0.87837870
98MP0002078_abnormal_glucose_homeostasis0.87663311
99MP0002295_abnormal_pulmonary_circulatio0.87364007
100MP0002925_abnormal_cardiovascular_devel0.87125183
101MP0000759_abnormal_skeletal_muscle0.86882144
102MP0003186_abnormal_redox_activity0.84869314
103MP0001873_stomach_inflammation0.83567413
104MP0002166_altered_tumor_susceptibility0.82048800
105MP0009278_abnormal_bone_marrow0.81633382
106MP0003303_peritoneal_inflammation0.79585306
107MP0009643_abnormal_urine_homeostasis0.78297946
108MP0003119_abnormal_digestive_system0.77947786
109MP0000538_abnormal_urinary_bladder0.77167083
110MP0010386_abnormal_urinary_bladder0.76226062
111MP0001756_abnormal_urination0.76221326
112MP0005448_abnormal_energy_balance0.75339632
113MP0001664_abnormal_digestion0.75070189
114MP0005365_abnormal_bile_salt0.72830652
115MP0001270_distended_abdomen0.71059493
116MP0005503_abnormal_tendon_morphology0.70530741
117MP0003011_delayed_dark_adaptation0.69312015
118MP0006072_abnormal_retinal_apoptosis0.68266471
119MP0005319_abnormal_enzyme/_coenzyme0.68153718
120MP0005535_abnormal_body_temperature0.67805495
121MP0002108_abnormal_muscle_morphology0.67662044
122MP0002933_joint_inflammation0.64733402
123MP0001915_intracranial_hemorrhage0.64620041
124MP0004883_abnormal_blood_vessel0.64481238
125MP0003385_abnormal_body_wall0.64125861
126MP0003191_abnormal_cellular_cholesterol0.63609701
127MP0003950_abnormal_plasma_membrane0.60841478
128MP0001784_abnormal_fluid_regulation0.58586416
129MP0000609_abnormal_liver_physiology0.57580068
130MP0001243_abnormal_dermal_layer0.57520935
131MP0003091_abnormal_cell_migration0.57225327
132MP0001533_abnormal_skeleton_physiology0.56266917
133MP0008961_abnormal_basal_metabolism0.55827130
134* MP0009763_increased_sensitivity_to0.54520817
135MP0003221_abnormal_cardiomyocyte_apopto0.54462414
136MP0002009_preneoplasia0.52698984
137MP0002971_abnormal_brown_adipose0.52622536
138MP0003045_fibrosis0.52248491
139MP0006036_abnormal_mitochondrial_physio0.51778590
140MP0004510_myositis0.51664653

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)6.65391759
2Ventricular tachycardia (HP:0004756)6.04568090
3Broad metatarsal (HP:0001783)6.04288036
4Hypoplastic ischia (HP:0003175)4.82959581
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.78191232
6Sudden death (HP:0001699)4.72437150
7Complement deficiency (HP:0004431)4.42621450
8Abnormality of the ischium (HP:0003174)4.35728940
9Prolonged partial thromboplastin time (HP:0003645)4.33566660
10Muscle fiber splitting (HP:0003555)4.30320739
11Atrial fibrillation (HP:0005110)4.28326410
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.22978904
13Hyperlipoproteinemia (HP:0010980)4.22046088
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.17405650
15Congenital, generalized hypertrichosis (HP:0004540)4.13905990
16Lipoatrophy (HP:0100578)3.99593785
17Primary atrial arrhythmia (HP:0001692)3.95955505
18Increased connective tissue (HP:0009025)3.95269109
19Supraventricular arrhythmia (HP:0005115)3.88655394
20Exercise-induced myalgia (HP:0003738)3.88160789
21Supraventricular tachycardia (HP:0004755)3.79477127
22Vascular calcification (HP:0004934)3.64533313
23Large for gestational age (HP:0001520)3.62313751
24Right ventricular cardiomyopathy (HP:0011663)3.59945738
25Hyporeflexia of lower limbs (HP:0002600)3.59625976
26Calf muscle hypertrophy (HP:0008981)3.59411154
27Lymphangioma (HP:0100764)3.53838018
28Mitral stenosis (HP:0001718)3.44522887
29Exercise-induced muscle cramps (HP:0003710)3.41406395
30Cardiovascular calcification (HP:0011915)3.39920165
31Aortic dissection (HP:0002647)3.39841704
32Muscle hypertrophy of the lower extremities (HP:0008968)3.27510359
33Increased variability in muscle fiber diameter (HP:0003557)3.21913360
34Type 1 muscle fiber predominance (HP:0003803)3.19392313
35Abnormality of complement system (HP:0005339)3.18745319
36Dilated cardiomyopathy (HP:0001644)3.12911966
37Premature rupture of membranes (HP:0001788)3.11260887
38Abnormality of the calf musculature (HP:0001430)3.10821755
39Myoglobinuria (HP:0002913)3.10648633
40Difficulty running (HP:0009046)3.07951795
41Polycythemia (HP:0001901)3.06576270
42Joint hemorrhage (HP:0005261)3.05583056
43* Short hallux (HP:0010109)3.03716194
44Aortic aneurysm (HP:0004942)3.02346536
45Bone cyst (HP:0012062)2.98912327
46Cerebral aneurysm (HP:0004944)2.93419854
47Abnormality of skeletal muscle fiber size (HP:0012084)2.92778875
48Venous insufficiency (HP:0005293)2.87284214
49Deep venous thrombosis (HP:0002625)2.86592543
50Venous abnormality (HP:0002624)2.82367583
51* Aplasia/Hypoplasia of the hallux (HP:0008362)2.80990283
52Syncope (HP:0001279)2.74462810
53Hypobetalipoproteinemia (HP:0003563)2.70024381
54Capillary hemangiomas (HP:0005306)2.69128746
55Hypoglycemic coma (HP:0001325)2.65699626
56Lymphedema (HP:0001004)2.65672819
57Protrusio acetabuli (HP:0003179)2.64265885
58Xanthomatosis (HP:0000991)2.62448503
59EMG: myopathic abnormalities (HP:0003458)2.61535525
60Palpitations (HP:0001962)2.56949404
61Hypoalphalipoproteinemia (HP:0003233)2.54099738
62Ketoacidosis (HP:0001993)2.51182318
63Ankle contracture (HP:0006466)2.48559750
64Bundle branch block (HP:0011710)2.46572368
65Spontaneous hematomas (HP:0007420)2.45367770
66Bicuspid aortic valve (HP:0001647)2.44516739
67Facial diplegia (HP:0001349)2.40220035
68Aneurysm (HP:0002617)2.39503044
69Delayed CNS myelination (HP:0002188)2.39106296
70Rhabdomyolysis (HP:0003201)2.38040791
71Hematochezia (HP:0002573)2.37751304
72Asymmetric septal hypertrophy (HP:0001670)2.37716857
73Intrahepatic cholestasis (HP:0001406)2.36407576
74Left ventricular hypertrophy (HP:0001712)2.33823176
75Spontaneous abortion (HP:0005268)2.33074797
76Pheochromocytoma (HP:0002666)2.32877465
77Abnormality of the intrinsic pathway (HP:0010989)2.32515687
78Facial shape deformation (HP:0011334)2.32079101
79Potter facies (HP:0002009)2.32079101
80Prolonged QT interval (HP:0001657)2.31871461
81Abnormality of urine glucose concentration (HP:0011016)2.31126543
82Glycosuria (HP:0003076)2.31126543
83Ulnar claw (HP:0001178)2.27125700
84Myotonia (HP:0002486)2.24931677
85Cerebral hemorrhage (HP:0001342)2.23907191
86Systemic lupus erythematosus (HP:0002725)2.23886486
87Chondrocalcinosis (HP:0000934)2.23689091
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22624445
89Hypolipoproteinemia (HP:0010981)2.22601862
90Abnormality of the pubic bones (HP:0003172)2.22192776
91Abnormality of the nasal mucosa (HP:0000433)2.18994551
92Muscle stiffness (HP:0003552)2.18604360
93Arthropathy (HP:0003040)2.17422308
94Abnormality of the left ventricular outflow tract (HP:0011103)2.16812476
95Subaortic stenosis (HP:0001682)2.16812476
96Ventricular arrhythmia (HP:0004308)2.16111289
97Esophageal varix (HP:0002040)2.14980233
98Glomerulonephritis (HP:0000099)2.13506101
99Axonal loss (HP:0003447)2.13277350
100Large hands (HP:0001176)2.12615428
101Heart block (HP:0012722)2.12352014
102Distal arthrogryposis (HP:0005684)2.11438425
103Abnormality of Sharpey fibers (HP:0100685)2.09934781
104Double outlet right ventricle (HP:0001719)2.08931566
105Congenital malformation of the right heart (HP:0011723)2.08931566
106* Prominent supraorbital ridges (HP:0000336)2.08182627
107Abnormality of fatty-acid metabolism (HP:0004359)2.07306718
108Steatorrhea (HP:0002570)2.07112669
109Atrioventricular block (HP:0001678)2.06735218
110Abnormal atrioventricular conduction (HP:0005150)2.05051075
111Hyperglycinemia (HP:0002154)2.03856171
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03586879
113Dicarboxylic aciduria (HP:0003215)2.03586879
114Hypoplastic left heart (HP:0004383)2.03583199
115Ketosis (HP:0001946)2.01864056
116Visceral angiomatosis (HP:0100761)2.01695843
117Round ear (HP:0100830)2.00655183
118Neuroendocrine neoplasm (HP:0100634)2.00579877
119Mesangial abnormality (HP:0001966)2.00366816
120Abnormality of the common coagulation pathway (HP:0010990)2.00319056
121Fat malabsorption (HP:0002630)1.99270535
122Pulmonary artery stenosis (HP:0004415)1.95636500
123Scotoma (HP:0000575)1.95462591
124Difficulty climbing stairs (HP:0003551)1.95410053
125Stroke (HP:0001297)1.93867323
126Palpebral edema (HP:0100540)1.93634555
127Spinal rigidity (HP:0003306)1.92928459
128Insulin-resistant diabetes mellitus (HP:0000831)1.91720068
129Broad hallux (HP:0010055)1.90494699
130Abnormality of the vitreous humor (HP:0004327)1.89909031
131Abnormal EKG (HP:0003115)1.87593670
132Hyperinsulinemic hypoglycemia (HP:0000825)1.86460360
133Rimmed vacuoles (HP:0003805)1.86390319
134Congestive heart failure (HP:0001635)1.86036898
135Abnormality of the sella turcica (HP:0002679)1.85694498
136Hemangiomatosis (HP:0007461)1.85666407
137Toxemia of pregnancy (HP:0100603)1.84757283
138Mildly elevated creatine phosphokinase (HP:0008180)1.84046045
139Hemiparesis (HP:0001269)1.82000326
140Generalized aminoaciduria (HP:0002909)1.81901739
141Conjugated hyperbilirubinemia (HP:0002908)1.78832905
142Striae distensae (HP:0001065)1.78710062
143Abnormality of glycine metabolism (HP:0010895)1.76515708
144Abnormality of serine family amino acid metabolism (HP:0010894)1.76515708
145Muscle fiber inclusion bodies (HP:0100299)1.76294596
146Reduced antithrombin III activity (HP:0001976)1.75921076
147Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75288648
148Nausea (HP:0002018)1.74276988
149Ventricular fibrillation (HP:0001663)1.74209585
150Testicular atrophy (HP:0000029)1.73446979
151Abnormality of the foot musculature (HP:0001436)1.71949009
152Skin nodule (HP:0200036)1.71326561
153Hyperammonemia (HP:0001987)1.69098692
154Hyperglycinuria (HP:0003108)1.68502378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.48412834
2TTN3.65051147
3MYLK3.55199437
4STK393.01091592
5TGFBR22.87788479
6PDGFRA2.12944249
7KDR10.1316430
8PNCK1.82532374
9ERN11.81158317
10DMPK1.73940016
11BMPR1B1.73776042
12LMTK21.73602752
13RIPK11.63079781
14NLK1.61546343
15MAP3K41.56775779
16PHKG11.52242385
17PHKG21.52242385
18TGFBR11.44611175
19OBSCN1.43974825
20TRIB31.43855665
21MAP3K61.43135648
22NTRK31.42907603
23JAK11.41677347
24EPHB21.36585044
25ACVR1B1.29318711
26PKN21.27493892
27PRKCE1.25745491
28KIT1.24639177
29MAP2K71.24432324
30BCKDK1.23140418
31PTK2B1.15733743
32CAMK41.13082279
33PRKG11.12141073
34MAP3K21.11770488
35PAK31.10355128
36PDK21.08087459
37PDK31.04892567
38PDK41.04892567
39MAPK121.01450568
40EPHB10.99398546
41JAK30.98704887
42ROCK20.94878952
43OXSR10.94632961
44CDK30.94096626
45GRK10.90568040
46DAPK20.87445745
47WNK40.86821387
48PTK60.86371970
49WNK30.86215280
50FGFR40.84434566
51LIMK10.82312586
52ADRBK20.81465939
53PIK3CA0.80896766
54RAF10.80776259
55MAP2K30.78668336
56JAK20.76026814
57AKT20.73897558
58SIK10.73445068
59PDGFRB0.73346597
60PAK20.73203848
61CAMK2G0.72720795
62CASK0.72281340
63NUAK10.72279249
64ROCK10.71428848
65FLT30.69320640
66FER0.68335191
67PRKACA0.67589563
68ITK0.67481356
69PRKD10.66711230
70SGK20.62999102
71PRKACG0.62927297
72PRKAA20.62868211
73NEK90.62144260
74MET0.62086455
75CAMK2B0.61389020
76STK40.61225012
77RET0.61012151
78MAP2K40.60679643
79FGFR20.57459218
80PKN10.56230581
81MAP2K10.55755141
82STK110.55431029
83DAPK30.54988927
84PTK20.54764871
85EPHA30.54082892
86EIF2AK30.54050378
87IRAK10.52428125
88MAP2K60.52295956
89CSK0.51753395
90PRKG20.51183954
91CDK90.50098974
92PRKCH0.49939451
93STK240.49038958
94MAPK150.48351387
95RPS6KA60.47860934
96RPS6KL10.46941257
97RPS6KC10.46941257
98CAMK1D0.46007848
99MAP3K70.45799345
100GRK70.45408088
101PRKCG0.45077367
102ILK0.44146560
103CDC42BPA0.43770509
104CCNB10.43658100
105MAP3K110.43391360
106SGK2230.43275863
107SGK4940.43275863
108PRKD20.43072778
109ABL20.42026322
110INSRR0.41961560
111CAMK1G0.37699647
112MAPK70.37266258
113MAPKAPK30.36322104
114PIK3CG0.36005964
115MAP3K30.35866288
116FGFR30.34638999
117TYK20.32646880
118LRRK20.31342222
119IGF1R0.31159795
120PRKAA10.30449545
121CAMK2A0.29901652
122TBK10.29398475
123GSK3A0.28031202
124NTRK10.27927878
125MAP2K20.27813313
126TAOK10.27551814
127MAP3K10.26817359
128SRC0.26800906
129INSR0.26237841
130MUSK0.25705504
131DDR20.25071185
132MAP3K100.25025363
133PINK10.24898685
134ADRBK10.23722888
135FRK0.22545891
136LATS10.22169375
137STK380.20776391
138CAMK10.20661238
139PRKACB0.20647082
140CAMK2D0.20392102
141KSR20.20385327
142TRPM70.20088468

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.50161507
2Fatty acid degradation_Homo sapiens_hsa000712.86603870
3Propanoate metabolism_Homo sapiens_hsa006402.79819348
4Dilated cardiomyopathy_Homo sapiens_hsa054142.70308765
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.65358698
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.61806684
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.45477307
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43554814
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26125356
10Complement and coagulation cascades_Homo sapiens_hsa046102.21490476
11Malaria_Homo sapiens_hsa051442.17129034
12Retinol metabolism_Homo sapiens_hsa008302.10935566
13PPAR signaling pathway_Homo sapiens_hsa033202.08352656
14Cardiac muscle contraction_Homo sapiens_hsa042602.06379957
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06127658
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00160853
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99553736
18Chemical carcinogenesis_Homo sapiens_hsa052041.99439986
19Fatty acid metabolism_Homo sapiens_hsa012121.99391439
20Focal adhesion_Homo sapiens_hsa045101.97143041
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.91208570
22ECM-receptor interaction_Homo sapiens_hsa045121.89796043
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86152392
24Tyrosine metabolism_Homo sapiens_hsa003501.80785447
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.76424238
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54502363
27Arginine biosynthesis_Homo sapiens_hsa002201.44203276
28Sulfur metabolism_Homo sapiens_hsa009201.40051700
29Linoleic acid metabolism_Homo sapiens_hsa005911.39470269
30African trypanosomiasis_Homo sapiens_hsa051431.36673669
31Viral myocarditis_Homo sapiens_hsa054161.35201000
32Carbon metabolism_Homo sapiens_hsa012001.33836593
33ABC transporters_Homo sapiens_hsa020101.32443690
34Tryptophan metabolism_Homo sapiens_hsa003801.31890541
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31093447
36Histidine metabolism_Homo sapiens_hsa003401.29643032
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.28834109
38Folate biosynthesis_Homo sapiens_hsa007901.28435178
39Butanoate metabolism_Homo sapiens_hsa006501.27944771
40Bile secretion_Homo sapiens_hsa049761.24810576
41Sulfur relay system_Homo sapiens_hsa041221.24515465
42Parkinsons disease_Homo sapiens_hsa050121.24321242
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.23827456
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18868057
45Pyruvate metabolism_Homo sapiens_hsa006201.15964238
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.14204140
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13996984
48Insulin resistance_Homo sapiens_hsa049311.10960823
49Oxidative phosphorylation_Homo sapiens_hsa001901.07572245
50Nitrogen metabolism_Homo sapiens_hsa009101.06761084
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.05575112
52Alzheimers disease_Homo sapiens_hsa050101.04619015
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98778955
54Starch and sucrose metabolism_Homo sapiens_hsa005000.97788486
55* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96613823
56Rap1 signaling pathway_Homo sapiens_hsa040150.95176464
57Renin secretion_Homo sapiens_hsa049240.92286585
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91938157
59Prion diseases_Homo sapiens_hsa050200.91081461
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.89987920
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89596131
62Insulin secretion_Homo sapiens_hsa049110.86689703
63Notch signaling pathway_Homo sapiens_hsa043300.84704152
64Circadian rhythm_Homo sapiens_hsa047100.84271465
65Protein digestion and absorption_Homo sapiens_hsa049740.83867388
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82747274
67Amoebiasis_Homo sapiens_hsa051460.82475899
68Dorso-ventral axis formation_Homo sapiens_hsa043200.82402980
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82093993
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80320633
71beta-Alanine metabolism_Homo sapiens_hsa004100.79407316
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78659359
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78583862
74Platelet activation_Homo sapiens_hsa046110.78083166
75Arachidonic acid metabolism_Homo sapiens_hsa005900.77923989
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77423014
77Staphylococcus aureus infection_Homo sapiens_hsa051500.77130362
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76724851
79Fatty acid elongation_Homo sapiens_hsa000620.75566925
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.75262526
81Adherens junction_Homo sapiens_hsa045200.71323106
82Pancreatic secretion_Homo sapiens_hsa049720.67269423
83Peroxisome_Homo sapiens_hsa041460.64791100
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62538086
85Lysine degradation_Homo sapiens_hsa003100.61399150
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61211317
87Oxytocin signaling pathway_Homo sapiens_hsa049210.60605453
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60067430
89Proteoglycans in cancer_Homo sapiens_hsa052050.58393198
90cAMP signaling pathway_Homo sapiens_hsa040240.58210757
91Mineral absorption_Homo sapiens_hsa049780.57768042
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56134620
93Fat digestion and absorption_Homo sapiens_hsa049750.55080880
94Phenylalanine metabolism_Homo sapiens_hsa003600.54851153
95Ras signaling pathway_Homo sapiens_hsa040140.53261589
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52912314
97Insulin signaling pathway_Homo sapiens_hsa049100.52901559
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52072012
99Calcium signaling pathway_Homo sapiens_hsa040200.51872821
100Glucagon signaling pathway_Homo sapiens_hsa049220.51696296
101Huntingtons disease_Homo sapiens_hsa050160.51049535
102Caffeine metabolism_Homo sapiens_hsa002320.49747079
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48919127
104AMPK signaling pathway_Homo sapiens_hsa041520.48363054
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48142587
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47415513
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47127693
108Vitamin digestion and absorption_Homo sapiens_hsa049770.46932286
109Selenocompound metabolism_Homo sapiens_hsa004500.45657963
110Arginine and proline metabolism_Homo sapiens_hsa003300.44877917
111Salivary secretion_Homo sapiens_hsa049700.44707172
112Tight junction_Homo sapiens_hsa045300.44325825
113TNF signaling pathway_Homo sapiens_hsa046680.43809626
114Gastric acid secretion_Homo sapiens_hsa049710.43765983
115Toxoplasmosis_Homo sapiens_hsa051450.43750636
116Metabolic pathways_Homo sapiens_hsa011000.43297387
117Serotonergic synapse_Homo sapiens_hsa047260.42844769
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.42828692
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42403411
120VEGF signaling pathway_Homo sapiens_hsa043700.42298668
121Gap junction_Homo sapiens_hsa045400.41879781
122Cocaine addiction_Homo sapiens_hsa050300.41603361
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41099813
124Glutathione metabolism_Homo sapiens_hsa004800.39185339
125Glycerolipid metabolism_Homo sapiens_hsa005610.36665788
126Small cell lung cancer_Homo sapiens_hsa052220.36247595
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35738808
128Pathways in cancer_Homo sapiens_hsa052000.35456020
129HIF-1 signaling pathway_Homo sapiens_hsa040660.34881370
130Fatty acid biosynthesis_Homo sapiens_hsa000610.33960931
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32866660
132Axon guidance_Homo sapiens_hsa043600.32790036
133Ovarian steroidogenesis_Homo sapiens_hsa049130.32774525
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.32384028
135GABAergic synapse_Homo sapiens_hsa047270.32189855
136Renal cell carcinoma_Homo sapiens_hsa052110.31451351
137Amphetamine addiction_Homo sapiens_hsa050310.30856491
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30823117
139Graft-versus-host disease_Homo sapiens_hsa053320.29967614
140Circadian entrainment_Homo sapiens_hsa047130.29848665
141Osteoclast differentiation_Homo sapiens_hsa043800.29279920
142Sphingolipid metabolism_Homo sapiens_hsa006000.29125304
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28274925

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