KCNJ9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.60987004
2synaptic vesicle maturation (GO:0016188)6.08848581
3synaptic vesicle exocytosis (GO:0016079)5.97968282
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.94914439
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.72233064
6locomotory exploration behavior (GO:0035641)5.71957397
7glutamate secretion (GO:0014047)5.64272045
8vocalization behavior (GO:0071625)5.63771024
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.43420928
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37076019
11regulation of synaptic vesicle exocytosis (GO:2000300)5.36410720
12neuronal action potential propagation (GO:0019227)5.15504102
13protein localization to synapse (GO:0035418)5.13191537
14ionotropic glutamate receptor signaling pathway (GO:0035235)5.06172565
15regulation of glutamate receptor signaling pathway (GO:1900449)4.98475124
16glutamate receptor signaling pathway (GO:0007215)4.75800088
17regulation of synaptic vesicle transport (GO:1902803)4.75543742
18neurotransmitter secretion (GO:0007269)4.68129109
19cellular potassium ion homeostasis (GO:0030007)4.67012525
20synaptic transmission, glutamatergic (GO:0035249)4.65071118
21amino acid import (GO:0043090)4.64297067
22axon ensheathment in central nervous system (GO:0032291)4.51793720
23central nervous system myelination (GO:0022010)4.51793720
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48765714
25exploration behavior (GO:0035640)4.46396511
26neuron-neuron synaptic transmission (GO:0007270)4.38871365
27regulation of neuronal synaptic plasticity (GO:0048168)4.37348830
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.34770051
29neurotransmitter-gated ion channel clustering (GO:0072578)4.33365493
30regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32730392
31neuron cell-cell adhesion (GO:0007158)4.28965855
32potassium ion import (GO:0010107)4.27039088
33long-term memory (GO:0007616)4.23986090
34neuronal ion channel clustering (GO:0045161)4.21445389
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.20313420
36positive regulation of synapse maturation (GO:0090129)4.17003544
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.08176451
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.06749208
39synaptic vesicle endocytosis (GO:0048488)4.01545046
40gamma-aminobutyric acid transport (GO:0015812)4.00704396
41sodium ion export (GO:0071436)4.00337387
42positive regulation of membrane potential (GO:0045838)3.98087943
43layer formation in cerebral cortex (GO:0021819)3.97234932
44regulation of ARF protein signal transduction (GO:0032012)3.96373432
45negative regulation of dendrite morphogenesis (GO:0050774)3.93937689
46regulation of postsynaptic membrane potential (GO:0060078)3.92651394
47cerebellar Purkinje cell differentiation (GO:0021702)3.92638028
48neurotransmitter transport (GO:0006836)3.85753270
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82037934
50long-term synaptic potentiation (GO:0060291)3.76153574
51regulation of synapse structural plasticity (GO:0051823)3.73608911
52neuromuscular process controlling posture (GO:0050884)3.73537653
53regulation of neurotransmitter secretion (GO:0046928)3.73186510
54cellular sodium ion homeostasis (GO:0006883)3.72538445
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.72104442
56response to pheromone (GO:0019236)3.69775922
57dendritic spine morphogenesis (GO:0060997)3.68777101
58regulation of synaptic plasticity (GO:0048167)3.67344400
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62365173
60proline transport (GO:0015824)3.61672874
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.59380393
62membrane hyperpolarization (GO:0060081)3.52801244
63neurotransmitter uptake (GO:0001504)3.51993863
64cerebellar granule cell differentiation (GO:0021707)3.50502757
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49983998
66regulation of neurotransmitter levels (GO:0001505)3.48848091
67acidic amino acid transport (GO:0015800)3.45742277
68transmission of nerve impulse (GO:0019226)3.44656868
69regulation of dendritic spine morphogenesis (GO:0061001)3.44174574
70membrane depolarization during action potential (GO:0086010)3.42615392
71membrane depolarization (GO:0051899)3.41721052
72activation of protein kinase A activity (GO:0034199)3.41403206
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40069881
74regulation of neurotransmitter transport (GO:0051588)3.39271782
75regulation of vesicle fusion (GO:0031338)3.36334853
76neuron recognition (GO:0008038)3.33438642
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.32451842
78positive regulation of neurotransmitter secretion (GO:0001956)3.30808955
79response to histamine (GO:0034776)3.29929781
80vesicle docking involved in exocytosis (GO:0006904)3.29009658
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28104279
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25983118
83dendritic spine organization (GO:0097061)3.25321416
84neuromuscular process controlling balance (GO:0050885)3.25299288
85long term synaptic depression (GO:0060292)3.24834563
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24713672
87regulation of synapse maturation (GO:0090128)3.22826300
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22493706
89cell communication by electrical coupling (GO:0010644)3.21426928
90cell differentiation in hindbrain (GO:0021533)3.18839230
91mating behavior (GO:0007617)3.17449616
92positive regulation of neurotransmitter transport (GO:0051590)3.16967508
93regulation of voltage-gated calcium channel activity (GO:1901385)3.16793253
94innervation (GO:0060384)3.16731870
95neuromuscular synaptic transmission (GO:0007274)3.15885533
96calcium ion-dependent exocytosis (GO:0017156)3.15520909
97postsynaptic membrane organization (GO:0001941)3.13390347
98* synaptic transmission (GO:0007268)3.13081960
99positive regulation of synaptic transmission (GO:0050806)3.12177576
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11924223
101regulation of synaptic transmission (GO:0050804)3.10499663
102response to auditory stimulus (GO:0010996)3.09451277
103learning (GO:0007612)3.08526550
104potassium ion homeostasis (GO:0055075)3.08492131
105neuromuscular process (GO:0050905)3.08206710
106regulation of exocytosis (GO:0017157)3.08023089
107presynaptic membrane assembly (GO:0097105)3.06478272
108L-glutamate transport (GO:0015813)3.05406874
109cerebellar Purkinje cell layer development (GO:0021680)3.03932989
110presynaptic membrane organization (GO:0097090)3.03814304
111vesicle docking (GO:0048278)3.03262466
112detection of calcium ion (GO:0005513)3.03130984
113behavioral defense response (GO:0002209)3.02502822
114behavioral fear response (GO:0001662)3.02502822
115L-amino acid import (GO:0043092)3.02199246
116positive regulation of dendritic spine morphogenesis (GO:0061003)3.01555438
117positive regulation of dendritic spine development (GO:0060999)3.01523846
118axonal fasciculation (GO:0007413)3.00560483
119synapse assembly (GO:0007416)3.00016228
120auditory behavior (GO:0031223)2.99484616
121regulation of dendritic spine development (GO:0060998)2.98023866
122establishment of synaptic vesicle localization (GO:0097480)2.95519918
123synaptic vesicle transport (GO:0048489)2.95519918
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94968588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.24589418
2GBX2_23144817_ChIP-Seq_PC3_Human3.58243895
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08198792
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05036412
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97536083
6REST_21632747_ChIP-Seq_MESCs_Mouse2.89849916
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68044091
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68044091
9DROSHA_22980978_ChIP-Seq_HELA_Human2.64031499
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62440353
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59857250
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.57458482
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52969843
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52325843
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51726299
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48795637
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.36901434
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34475927
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.33081876
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26716340
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.24369018
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24296379
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24150415
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15420784
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.13309567
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10564820
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94221262
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90829154
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88321520
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84837289
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83250111
32* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81101430
33TAF15_26573619_Chip-Seq_HEK293_Human1.80135035
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75898231
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71383611
36SMAD4_21799915_ChIP-Seq_A2780_Human1.67687673
37AR_21572438_ChIP-Seq_LNCaP_Human1.62503410
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59539928
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.50635425
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48107836
41ZNF274_21170338_ChIP-Seq_K562_Hela1.42268807
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40358342
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37873756
44TET1_21490601_ChIP-Seq_MESCs_Mouse1.36521347
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35743518
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34736208
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34420382
48P300_19829295_ChIP-Seq_ESCs_Human1.33901176
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29981279
50AR_25329375_ChIP-Seq_VCAP_Human1.28467212
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.26814322
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.25934657
53CTCF_27219007_Chip-Seq_Bcells_Human1.24996160
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24919950
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.24761569
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22489438
57STAT3_23295773_ChIP-Seq_U87_Human1.21470364
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.21410695
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21368922
60AR_19668381_ChIP-Seq_PC3_Human1.20507660
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20395666
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19082656
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18407364
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15557835
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14140809
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13965138
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.13663391
68LXR_22292898_ChIP-Seq_THP-1_Human1.12947714
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12530837
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12262378
71TCF4_23295773_ChIP-Seq_U87_Human1.12120161
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.11687395
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10727616
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10222045
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10100519
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09990136
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08402874
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.07688775
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07225343
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07074748
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05494224
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03863704
83RNF2_27304074_Chip-Seq_NSC_Mouse1.03165278
84OCT4_19829295_ChIP-Seq_ESCs_Human1.00835187
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99367365
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99053277
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.98881542
88RING1B_27294783_Chip-Seq_NPCs_Mouse0.98841704
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98601750
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98098290
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97715751
92TP53_16413492_ChIP-PET_HCT116_Human0.96983422
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96806807
94FUS_26573619_Chip-Seq_HEK293_Human0.96512817
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94954424
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.94353251
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94055568
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93987140
99SMC4_20622854_ChIP-Seq_HELA_Human0.92984684
100RUNX2_22187159_ChIP-Seq_PCA_Human0.92793213
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92741085
102* DPY_21335234_ChIP-Seq_ESCs_Mouse0.92436433
103VDR_22108803_ChIP-Seq_LS180_Human0.92116927
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.91992449
105KDM2B_26808549_Chip-Seq_K562_Human0.91880687
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91769829
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.91487419
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90572667
109AHR_22903824_ChIP-Seq_MCF-7_Human0.90166362
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89881237
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89611073
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88790356
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88683277
114IGF1R_20145208_ChIP-Seq_DFB_Human0.88302755
115* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88250501
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88203226
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87953627
118KLF4_19829295_ChIP-Seq_ESCs_Human0.87684302
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87465563
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87465563
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87061176
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.87005766
123* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86701331
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85833704
125ER_23166858_ChIP-Seq_MCF-7_Human0.85732222
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85724539
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83780409
128RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80411747
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80298911
130EGR1_19032775_ChIP-ChIP_M12_Human0.79503103
131MYC_19915707_ChIP-ChIP_AK7_Human0.78990491
132SMAD4_21741376_ChIP-Seq_ESCs_Human0.78033657
133KDM2B_26808549_Chip-Seq_DND41_Human0.75072318
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74937128
135* CREB1_26743006_Chip-Seq_LNCaP_Human0.74628255
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74388304
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.73522744
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.70983821
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67901030
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67305785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.64788903
2MP0003880_abnormal_central_pattern5.12247723
3* MP0003635_abnormal_synaptic_transmissio4.29631317
4MP0009046_muscle_twitch3.67380246
5MP0009745_abnormal_behavioral_response3.57355857
6MP0004270_analgesia3.49875046
7MP0002064_seizures3.45165859
8MP0002063_abnormal_learning/memory/cond3.36980834
9MP0001968_abnormal_touch/_nociception3.12136829
10MP0002572_abnormal_emotion/affect_behav2.88836398
11MP0002272_abnormal_nervous_system2.87272679
12MP0005423_abnormal_somatic_nervous2.75221928
13MP0001486_abnormal_startle_reflex2.66943516
14MP0002734_abnormal_mechanical_nocicepti2.59354031
15MP0001501_abnormal_sleep_pattern2.51798741
16MP0002736_abnormal_nociception_after2.43473676
17MP0001440_abnormal_grooming_behavior2.19604858
18MP0008569_lethality_at_weaning2.18239361
19MP0002822_catalepsy2.18177951
20MP0002067_abnormal_sensory_capabilities2.14925364
21MP0002735_abnormal_chemical_nociception2.14511096
22MP0003329_amyloid_beta_deposits1.92637193
23MP0001970_abnormal_pain_threshold1.86248892
24MP0002733_abnormal_thermal_nociception1.80845587
25MP0002184_abnormal_innervation1.78978057
26MP0003879_abnormal_hair_cell1.77313840
27MP0009780_abnormal_chondrocyte_physiolo1.72614574
28MP0002557_abnormal_social/conspecific_i1.71113188
29MP0001984_abnormal_olfaction1.70910708
30MP0005386_behavior/neurological_phenoty1.66384545
31MP0004924_abnormal_behavior1.66384545
32MP0004811_abnormal_neuron_physiology1.65203422
33MP0005551_abnormal_eye_electrophysiolog1.65148359
34MP0004858_abnormal_nervous_system1.49794035
35MP0003123_paternal_imprinting1.49358782
36MP0005646_abnormal_pituitary_gland1.49097556
37MP0002909_abnormal_adrenal_gland1.48960614
38MP0000778_abnormal_nervous_system1.48198156
39MP0001502_abnormal_circadian_rhythm1.47669548
40MP0000955_abnormal_spinal_cord1.46155310
41MP0002066_abnormal_motor_capabilities/c1.44396146
42MP0003633_abnormal_nervous_system1.43928608
43MP0003787_abnormal_imprinting1.42212059
44MP0002882_abnormal_neuron_morphology1.41261139
45MP0004142_abnormal_muscle_tone1.36556906
46MP0004145_abnormal_muscle_electrophysio1.35698888
47MP0006276_abnormal_autonomic_nervous1.31138569
48MP0004885_abnormal_endolymph1.30739691
49MP0003631_nervous_system_phenotype1.21902612
50MP0008872_abnormal_physiological_respon1.16339244
51MP0005410_abnormal_fertilization1.13045967
52MP0001529_abnormal_vocalization1.11668215
53MP0002229_neurodegeneration1.10984378
54MP0005645_abnormal_hypothalamus_physiol1.09992401
55MP0002090_abnormal_vision1.07954949
56MP0002152_abnormal_brain_morphology1.07281327
57MP0010386_abnormal_urinary_bladder1.06524947
58MP0004147_increased_porphyrin_level1.06208883
59MP0003122_maternal_imprinting1.02782760
60MP0000751_myopathy1.01774947
61MP0001905_abnormal_dopamine_level1.00667803
62MP0004742_abnormal_vestibular_system0.96064191
63MP0002069_abnormal_eating/drinking_beha0.92935955
64MP0008874_decreased_physiological_sensi0.91739451
65MP0001348_abnormal_lacrimal_gland0.91499374
66MP0004233_abnormal_muscle_weight0.91421036
67MP0001188_hyperpigmentation0.89101179
68MP0001346_abnormal_lacrimal_gland0.88867017
69MP0003075_altered_response_to0.88432105
70MP0003632_abnormal_nervous_system0.88066886
71MP0000013_abnormal_adipose_tissue0.85926736
72MP0000604_amyloidosis0.85824951
73MP0001177_atelectasis0.84985219
74MP0004215_abnormal_myocardial_fiber0.84741516
75MP0005535_abnormal_body_temperature0.84496020
76MP0001963_abnormal_hearing_physiology0.83479596
77MP0008961_abnormal_basal_metabolism0.82611444
78MP0006072_abnormal_retinal_apoptosis0.81021322
79MP0001986_abnormal_taste_sensitivity0.80707133
80MP0000920_abnormal_myelination0.79463830
81MP0002752_abnormal_somatic_nervous0.78973022
82MP0004085_abnormal_heartbeat0.78739594
83MP0003690_abnormal_glial_cell0.78266844
84MP0000569_abnormal_digit_pigmentation0.78168751
85MP0003634_abnormal_glial_cell0.76731415
86MP0005499_abnormal_olfactory_system0.76632289
87MP0005394_taste/olfaction_phenotype0.76632289
88MP0005623_abnormal_meninges_morphology0.70505804
89MP0002837_dystrophic_cardiac_calcinosis0.70073770
90MP0003283_abnormal_digestive_organ0.68611979
91MP0005253_abnormal_eye_physiology0.68283482
92MP0000631_abnormal_neuroendocrine_gland0.67889242
93MP0004043_abnormal_pH_regulation0.67873234
94MP0004510_myositis0.67450397
95MP0004484_altered_response_of0.66277888
96MP0002638_abnormal_pupillary_reflex0.65765528
97MP0004130_abnormal_muscle_cell0.62883091
98MP0003172_abnormal_lysosome_physiology0.62845872
99MP0003698_abnormal_male_reproductive0.61990772
100MP0002876_abnormal_thyroid_physiology0.59757375
101MP0000579_abnormal_nail_morphology0.59399295
102MP0003137_abnormal_impulse_conducting0.59046179
103MP0005167_abnormal_blood-brain_barrier0.58755107
104MP0001664_abnormal_digestion0.57148015
105MP0001485_abnormal_pinna_reflex0.56768144
106MP0008877_abnormal_DNA_methylation0.54851570
107MP0010769_abnormal_survival0.54167098
108MP0005166_decreased_susceptibility_to0.53916346
109MP0010768_mortality/aging0.52458374
110MP0010770_preweaning_lethality0.50510957
111MP0002082_postnatal_lethality0.50510957
112MP0001943_abnormal_respiration0.50340977
113MP0003956_abnormal_body_size0.50305251
114MP0005409_darkened_coat_color0.50043242
115MP0003121_genomic_imprinting0.45630688
116MP0002873_normal_phenotype0.43714139
117MP0003861_abnormal_nervous_system0.43626410
118MP0000026_abnormal_inner_ear0.43103730
119MP0002169_no_abnormal_phenotype0.41949962
120MP0003045_fibrosis0.41456099
121MP0002089_abnormal_postnatal_growth/wei0.40816584

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.39145563
2Myokymia (HP:0002411)6.38736628
3Focal seizures (HP:0007359)6.10499679
4Epileptic encephalopathy (HP:0200134)5.55307390
5Visual hallucinations (HP:0002367)5.48824303
6Atonic seizures (HP:0010819)5.46533603
7Febrile seizures (HP:0002373)5.26203138
8Absence seizures (HP:0002121)4.87526739
9Progressive cerebellar ataxia (HP:0002073)4.79797610
10Dialeptic seizures (HP:0011146)4.39899657
11Generalized tonic-clonic seizures (HP:0002069)4.16931425
12Gaze-evoked nystagmus (HP:0000640)4.13339885
13Action tremor (HP:0002345)4.08539862
14Dysdiadochokinesis (HP:0002075)3.71102224
15Cerebral hypomyelination (HP:0006808)3.68532103
16Broad-based gait (HP:0002136)3.68105452
17Obstructive sleep apnea (HP:0002870)3.60682948
18Limb dystonia (HP:0002451)3.52979384
19Hyperventilation (HP:0002883)3.44753027
20Poor eye contact (HP:0000817)3.39760727
21Dysmetria (HP:0001310)3.35946958
22Supranuclear gaze palsy (HP:0000605)3.26571106
23Impaired vibration sensation in the lower limbs (HP:0002166)3.25801377
24Truncal ataxia (HP:0002078)3.23300900
25Abnormality of the lower motor neuron (HP:0002366)3.19104933
26Depression (HP:0000716)3.18608549
27Impaired smooth pursuit (HP:0007772)3.17966922
28Urinary bladder sphincter dysfunction (HP:0002839)3.08080534
29Ankle clonus (HP:0011448)3.07912383
30Impaired social interactions (HP:0000735)3.07424183
31Abnormal social behavior (HP:0012433)3.07424183
32Hemiparesis (HP:0001269)3.06714020
33Dysmetric saccades (HP:0000641)3.03803161
34Scanning speech (HP:0002168)2.97551443
35Postural instability (HP:0002172)2.96451298
36Genetic anticipation (HP:0003743)2.95706041
37Akinesia (HP:0002304)2.94707314
38Abnormal eating behavior (HP:0100738)2.93938260
39Abnormality of ocular smooth pursuit (HP:0000617)2.92192305
40Anxiety (HP:0000739)2.85873499
41Amblyopia (HP:0000646)2.85202840
42Hemiplegia (HP:0002301)2.82946713
43Status epilepticus (HP:0002133)2.82775979
44Abnormality of binocular vision (HP:0011514)2.81595308
45Diplopia (HP:0000651)2.81595308
46Mutism (HP:0002300)2.78982622
47Peripheral hypomyelination (HP:0007182)2.73256989
48Intention tremor (HP:0002080)2.71637296
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.65486189
50Absent/shortened dynein arms (HP:0200106)2.65486189
51Apathy (HP:0000741)2.63914149
52Insomnia (HP:0100785)2.55465040
53Sleep apnea (HP:0010535)2.54799205
54Epileptiform EEG discharges (HP:0011182)2.54227299
55Excessive salivation (HP:0003781)2.53790889
56Drooling (HP:0002307)2.53790889
57Spastic gait (HP:0002064)2.53007422
58Ventricular fibrillation (HP:0001663)2.51469214
59Absent speech (HP:0001344)2.49495483
60Neurofibrillary tangles (HP:0002185)2.45579116
61Spastic tetraparesis (HP:0001285)2.41785579
62EEG with generalized epileptiform discharges (HP:0011198)2.40411733
63Stereotypic behavior (HP:0000733)2.39415331
64Bradykinesia (HP:0002067)2.39112026
65Progressive inability to walk (HP:0002505)2.38976499
66Impaired vibratory sensation (HP:0002495)2.38774821
67Urinary urgency (HP:0000012)2.37355306
68Choreoathetosis (HP:0001266)2.36633153
69Diminished motivation (HP:0000745)2.36418168
70Cerebral inclusion bodies (HP:0100314)2.33749033
71Central scotoma (HP:0000603)2.29403289
72Congenital stationary night blindness (HP:0007642)2.29306854
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.27412807
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27412807
75Papilledema (HP:0001085)2.26627428
76Generalized myoclonic seizures (HP:0002123)2.24719428
77CNS hypomyelination (HP:0003429)2.24256707
78Rapidly progressive (HP:0003678)2.20737492
79Abnormality of macular pigmentation (HP:0008002)2.17958445
80Inability to walk (HP:0002540)2.16027527
81Abnormality of saccadic eye movements (HP:0000570)2.15928949
82Torticollis (HP:0000473)2.14404768
83Gait ataxia (HP:0002066)2.13634286
84Fetal akinesia sequence (HP:0001989)2.13283215
85Morphological abnormality of the pyramidal tract (HP:0002062)2.12676117
86Hypsarrhythmia (HP:0002521)2.12566778
87Increased circulating renin level (HP:0000848)2.10960954
88Annular pancreas (HP:0001734)2.07543707
89Focal dystonia (HP:0004373)2.07319783
90Lower limb asymmetry (HP:0100559)2.05754644
91Neuronal loss in central nervous system (HP:0002529)2.03430712
92Lower limb muscle weakness (HP:0007340)1.99584106
93Spinal canal stenosis (HP:0003416)1.97734702
94Polyphagia (HP:0002591)1.97232821
95Limb ataxia (HP:0002070)1.94451713
96Incomplete penetrance (HP:0003829)1.94077820
97Memory impairment (HP:0002354)1.93612474
98Lower limb amyotrophy (HP:0007210)1.91834396
99Delusions (HP:0000746)1.89066702
100Abnormality of the corticospinal tract (HP:0002492)1.88823955
101Gait imbalance (HP:0002141)1.87079235
102Aplasia involving bones of the extremities (HP:0009825)1.84723592
103Aplasia involving bones of the upper limbs (HP:0009823)1.84723592
104Aplasia of the phalanges of the hand (HP:0009802)1.84723592
105Clonus (HP:0002169)1.84332156
106Termporal pattern (HP:0011008)1.82754858
107Insidious onset (HP:0003587)1.82754858
108Protruding tongue (HP:0010808)1.80922642
109Split foot (HP:0001839)1.80804620
110Psychosis (HP:0000709)1.80199239
111Tetraplegia (HP:0002445)1.79315085
112Heart block (HP:0012722)1.78140303
113Abnormal respiratory motile cilium physiology (HP:0012261)1.77872445
114Pointed chin (HP:0000307)1.77426710
115Abnormal ciliary motility (HP:0012262)1.75949024
116Specific learning disability (HP:0001328)1.75800308
117Amyotrophic lateral sclerosis (HP:0007354)1.75781753
118Blue irides (HP:0000635)1.75218601
119Pheochromocytoma (HP:0002666)1.75080997
120Craniofacial dystonia (HP:0012179)1.74576427
121Bundle branch block (HP:0011710)1.74191942
122Dementia (HP:0000726)1.73528215
123Megalencephaly (HP:0001355)1.73134497
124Agitation (HP:0000713)1.71949520
125Rigidity (HP:0002063)1.69002754
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68105593
127Abnormal EKG (HP:0003115)1.67352125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.31373925
2EPHA44.25751723
3MAP3K93.80748449
4MAP3K43.22074702
5DAPK22.84122712
6MAP2K72.59513186
7MINK12.50612848
8PAK62.41986565
9RIPK42.22020882
10PRKD32.17838214
11MARK12.03431073
12MAP2K42.02136390
13MAP3K122.01264389
14CASK1.98019948
15NTRK21.97678749
16CAMKK11.90207773
17KSR21.88555456
18CDK191.85128990
19PNCK1.80671788
20STK381.78976315
21DAPK11.75993533
22PRPF4B1.63231023
23NTRK11.56413419
24MAP3K131.56237464
25PLK21.51555259
26ARAF1.49691823
27CDK51.49446611
28TNIK1.48832979
29GRK51.42633955
30KSR11.41224056
31CAMKK21.38089534
32SIK21.37392034
33FES1.31347505
34PRKCG1.29808573
35TYRO31.18619299
36CAMK11.10239250
37PTK2B1.07895582
38OXSR11.01933100
39CAMK2A0.99646665
40MAPK130.96383349
41CDK180.94556979
42CDK150.93891239
43STK110.92855732
44PINK10.92020181
45UHMK10.90523666
46SGK4940.88718571
47SGK2230.88718571
48MAPK120.88378103
49TNK20.87515139
50CDK140.87420944
51CDK11A0.82205029
52BMPR20.82069815
53CCNB10.81250533
54TAOK10.79589541
55RAF10.79385352
56PRKCH0.78808057
57RIPK10.78700290
58CAMK2B0.78427869
59DYRK1A0.78274593
60PDK10.76222657
61PKN10.73898670
62PDK30.71494304
63PDK40.71494304
64MAP3K20.70995267
65SGK20.69740338
66WNK10.69712654
67CAMK1G0.69356986
68SGK10.67672761
69MAP3K110.66395667
70PAK30.65458747
71PDPK10.65319169
72RET0.62553112
73PHKG10.62181908
74PHKG20.62181908
75NEK60.59424310
76SGK30.58961738
77FGFR20.55535814
78ALK0.55391563
79NEK10.55021554
80CAMK2D0.54945730
81MARK20.54776258
82MAP3K10.54302858
83MAP3K70.53463272
84LIMK10.53406107
85NME10.53106433
86CDC42BPA0.52171308
87RPS6KA30.51654833
88DAPK30.49992544
89FER0.49586358
90LATS20.49357676
91CAMK40.49349029
92CAMK2G0.47455265
93PRKCE0.46385028
94MAPK100.45218028
95AKT30.44370751
96PRKCZ0.43142835
97BRAF0.41873142
98LMTK20.41480017
99FGR0.40760421
100FYN0.40291404
101MAP3K60.39748416
102ROCK20.39521144
103BRSK10.35537342
104MUSK0.34222327
105PRKCA0.33706694
106TESK10.33426692
107PRKG20.29835095
108ERBB20.28238168
109MAPKAPK50.27853165
110IRAK20.26784753
111CSNK1G20.26611128
112ROCK10.26434684
113MAPK80.25873343
114PRKCB0.24932285
115JAK20.24834457
116MAP2K60.24276494

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.32281475
2Synaptic vesicle cycle_Homo sapiens_hsa047213.62179007
3GABAergic synapse_Homo sapiens_hsa047272.91306536
4* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86514072
5Glutamatergic synapse_Homo sapiens_hsa047242.72965007
6Long-term potentiation_Homo sapiens_hsa047202.72462223
7* Circadian entrainment_Homo sapiens_hsa047132.71204377
8Olfactory transduction_Homo sapiens_hsa047402.64580543
9* Morphine addiction_Homo sapiens_hsa050322.59204867
10Amphetamine addiction_Homo sapiens_hsa050312.41924845
11Salivary secretion_Homo sapiens_hsa049702.33990796
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19617265
13Insulin secretion_Homo sapiens_hsa049112.12306013
14* Dopaminergic synapse_Homo sapiens_hsa047281.97287534
15Taste transduction_Homo sapiens_hsa047421.92662996
16Gastric acid secretion_Homo sapiens_hsa049711.91999832
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87954243
18Cholinergic synapse_Homo sapiens_hsa047251.82483475
19Long-term depression_Homo sapiens_hsa047301.75996844
20Renin secretion_Homo sapiens_hsa049241.75435879
21Collecting duct acid secretion_Homo sapiens_hsa049661.71968050
22Calcium signaling pathway_Homo sapiens_hsa040201.71029481
23* Oxytocin signaling pathway_Homo sapiens_hsa049211.66168933
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65829984
25Vitamin B6 metabolism_Homo sapiens_hsa007501.57783513
26* Serotonergic synapse_Homo sapiens_hsa047261.49618666
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44027046
28GnRH signaling pathway_Homo sapiens_hsa049121.39911618
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37354469
30Cocaine addiction_Homo sapiens_hsa050301.37052612
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32466314
32cAMP signaling pathway_Homo sapiens_hsa040241.28393816
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24127333
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23699045
35Gap junction_Homo sapiens_hsa045401.21836744
36Type II diabetes mellitus_Homo sapiens_hsa049301.17034295
37Cardiac muscle contraction_Homo sapiens_hsa042601.14791088
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11573780
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11255241
40Phototransduction_Homo sapiens_hsa047441.10894152
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10656782
42* Estrogen signaling pathway_Homo sapiens_hsa049151.01116754
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00384724
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.97027439
45Pancreatic secretion_Homo sapiens_hsa049720.96185184
46Vibrio cholerae infection_Homo sapiens_hsa051100.94726339
47Glioma_Homo sapiens_hsa052140.91692874
48Nitrogen metabolism_Homo sapiens_hsa009100.91569980
49Melanogenesis_Homo sapiens_hsa049160.90642812
50Axon guidance_Homo sapiens_hsa043600.86575319
51ErbB signaling pathway_Homo sapiens_hsa040120.85615678
52Oocyte meiosis_Homo sapiens_hsa041140.85136953
53Thyroid hormone synthesis_Homo sapiens_hsa049180.80706356
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80375342
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.79195024
56Dorso-ventral axis formation_Homo sapiens_hsa043200.78008999
57Dilated cardiomyopathy_Homo sapiens_hsa054140.74334197
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69758045
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69236014
60Circadian rhythm_Homo sapiens_hsa047100.69024193
61Inositol phosphate metabolism_Homo sapiens_hsa005620.67450667
62MAPK signaling pathway_Homo sapiens_hsa040100.66339932
63Glucagon signaling pathway_Homo sapiens_hsa049220.64342100
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63461051
65Choline metabolism in cancer_Homo sapiens_hsa052310.62557880
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62400432
67Bile secretion_Homo sapiens_hsa049760.55158687
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53949280
69VEGF signaling pathway_Homo sapiens_hsa043700.52558211
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47431012
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46942396
72Arginine and proline metabolism_Homo sapiens_hsa003300.46383977
73Ras signaling pathway_Homo sapiens_hsa040140.44805689
74Type I diabetes mellitus_Homo sapiens_hsa049400.44236163
75Rap1 signaling pathway_Homo sapiens_hsa040150.42966440
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.42526021
77mTOR signaling pathway_Homo sapiens_hsa041500.42319851
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42163255
79Arginine biosynthesis_Homo sapiens_hsa002200.41921909
80Endocytosis_Homo sapiens_hsa041440.41572195
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.40128807
82Alzheimers disease_Homo sapiens_hsa050100.40043444
83Alcoholism_Homo sapiens_hsa050340.39550653
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39325592
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39234673
86Histidine metabolism_Homo sapiens_hsa003400.38853867
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37382923
88African trypanosomiasis_Homo sapiens_hsa051430.37112001
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36826045
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36301288
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36118293
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34763865
93Wnt signaling pathway_Homo sapiens_hsa043100.32161831
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32062688
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31505248
96Fatty acid biosynthesis_Homo sapiens_hsa000610.30519213
97Ovarian steroidogenesis_Homo sapiens_hsa049130.30130947
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.29919865
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29205154
100Prion diseases_Homo sapiens_hsa050200.29033622
101Mineral absorption_Homo sapiens_hsa049780.26432241
102Chemokine signaling pathway_Homo sapiens_hsa040620.25175212
103Insulin signaling pathway_Homo sapiens_hsa049100.24890096
104Rheumatoid arthritis_Homo sapiens_hsa053230.24627321
105HIF-1 signaling pathway_Homo sapiens_hsa040660.23787039
106Renal cell carcinoma_Homo sapiens_hsa052110.22822443
107beta-Alanine metabolism_Homo sapiens_hsa004100.22289934
108AMPK signaling pathway_Homo sapiens_hsa041520.21900025
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21328638
110Non-small cell lung cancer_Homo sapiens_hsa052230.21303838
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21164369
112Tight junction_Homo sapiens_hsa045300.20475003
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18150526

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