KCNK10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.64447409
2neuron cell-cell adhesion (GO:0007158)5.80910893
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.45225999
4negative regulation of translation, ncRNA-mediated (GO:0040033)5.45225999
5regulation of translation, ncRNA-mediated (GO:0045974)5.45225999
6nucleobase catabolic process (GO:0046113)5.44840571
7piRNA metabolic process (GO:0034587)5.31743134
8vocalization behavior (GO:0071625)5.07780822
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04724776
10microtubule depolymerization (GO:0007019)4.94315799
11gonadal mesoderm development (GO:0007506)4.92134335
12layer formation in cerebral cortex (GO:0021819)4.91236768
13neuron recognition (GO:0008038)4.88831888
14protein localization to cilium (GO:0061512)4.85881532
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58087276
16behavioral response to nicotine (GO:0035095)4.50277560
17cell migration in hindbrain (GO:0021535)4.39642214
18axonal fasciculation (GO:0007413)4.37371809
19nonmotile primary cilium assembly (GO:0035058)4.23345350
20cilium or flagellum-dependent cell motility (GO:0001539)4.22674744
21locomotory exploration behavior (GO:0035641)4.13609282
22cerebellum development (GO:0021549)4.04790131
23axonemal dynein complex assembly (GO:0070286)4.03477014
24protein localization to synapse (GO:0035418)3.96400598
25response to pheromone (GO:0019236)3.94261675
26postsynaptic membrane organization (GO:0001941)3.93952610
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.91620571
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.90076544
29dendritic spine morphogenesis (GO:0060997)3.84882880
30dendrite morphogenesis (GO:0048813)3.84431745
31negative regulation of microtubule polymerization (GO:0031115)3.83818283
32regulation of glutamate receptor signaling pathway (GO:1900449)3.81628038
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80805709
34pre-miRNA processing (GO:0031054)3.75848691
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.73429545
36central nervous system projection neuron axonogenesis (GO:0021952)3.71720984
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.68813940
38synaptic vesicle exocytosis (GO:0016079)3.68553681
39neurotransmitter-gated ion channel clustering (GO:0072578)3.66427383
40motile cilium assembly (GO:0044458)3.63800796
41cerebellar granule cell differentiation (GO:0021707)3.63417728
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62494740
43exploration behavior (GO:0035640)3.62169032
44intraciliary transport (GO:0042073)3.61646007
45glutamate secretion (GO:0014047)3.59306405
46acrosome reaction (GO:0007340)3.56089198
47regulation of action potential (GO:0098900)3.52898698
48positive regulation of synapse maturation (GO:0090129)3.48430089
49epithelial cilium movement (GO:0003351)3.47779589
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44611498
51glutamate receptor signaling pathway (GO:0007215)3.40261262
52neurotransmitter secretion (GO:0007269)3.38657334
53regulation of synaptic vesicle exocytosis (GO:2000300)3.36351190
54startle response (GO:0001964)3.34139343
55presynaptic membrane assembly (GO:0097105)3.33422641
56positive regulation of synapse assembly (GO:0051965)3.32419129
57retinal ganglion cell axon guidance (GO:0031290)3.32354767
58male genitalia development (GO:0030539)3.24830293
59synaptic vesicle maturation (GO:0016188)3.20506898
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20033182
61regulation of synapse structural plasticity (GO:0051823)3.18423543
62calcium ion-dependent exocytosis (GO:0017156)3.17424054
63tachykinin receptor signaling pathway (GO:0007217)3.16698168
64water-soluble vitamin biosynthetic process (GO:0042364)3.16219372
65lipoprotein transport (GO:0042953)3.14855184
66axon extension (GO:0048675)3.14394755
67synapse assembly (GO:0007416)3.13832649
68innervation (GO:0060384)3.09851491
69presynaptic membrane organization (GO:0097090)3.08376095
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06160981
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.03637842
72negative regulation of astrocyte differentiation (GO:0048712)3.03187234
73synaptic transmission, glutamatergic (GO:0035249)3.02066730
74regulation of development, heterochronic (GO:0040034)3.01250208
75regulation of timing of cell differentiation (GO:0048505)3.01140425
76transmission of nerve impulse (GO:0019226)2.99921783
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99040128
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98713376
79mitochondrion transport along microtubule (GO:0047497)2.98713376
80DNA methylation involved in gamete generation (GO:0043046)2.98328659
81mechanosensory behavior (GO:0007638)2.97912065
82neuron fate determination (GO:0048664)2.97622062
83olfactory bulb development (GO:0021772)2.96672606
84appendage development (GO:0048736)2.94481834
85limb development (GO:0060173)2.94481834
86central nervous system myelination (GO:0022010)2.94421801
87axon ensheathment in central nervous system (GO:0032291)2.94421801
88regulation of neuronal synaptic plasticity (GO:0048168)2.93855001
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93779069
90establishment of mitochondrion localization (GO:0051654)2.93357603
91synaptic vesicle endocytosis (GO:0048488)2.93351607
92calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.89553286
93limb bud formation (GO:0060174)2.89056026
94auditory behavior (GO:0031223)2.88679742
95central nervous system neuron axonogenesis (GO:0021955)2.88601023
96cilium movement (GO:0003341)2.87166668
97cerebellar Purkinje cell differentiation (GO:0021702)2.86635080
98proline transport (GO:0015824)2.86382335
99hippocampus development (GO:0021766)2.85191211
100regulation of dendritic spine morphogenesis (GO:0061001)2.84562897
101gamma-aminobutyric acid transport (GO:0015812)2.83962244
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83384541
103protein polyglutamylation (GO:0018095)2.81405204
104synapse organization (GO:0050808)2.81203011
105regulation of respiratory system process (GO:0044065)2.80781157
106spinal cord development (GO:0021510)2.79938729
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79704741
108cilium assembly (GO:0042384)2.79649440
109S-adenosylmethionine metabolic process (GO:0046500)2.79638375
110neuron-neuron synaptic transmission (GO:0007270)2.78837957
111cilium organization (GO:0044782)2.78299851
112cerebral cortex radially oriented cell migration (GO:0021799)2.78038127
113negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77501987
114regulation of cilium movement (GO:0003352)2.75151974
115L-fucose metabolic process (GO:0042354)2.74633476
116L-fucose catabolic process (GO:0042355)2.74633476
117fucose catabolic process (GO:0019317)2.74633476
118cell differentiation in hindbrain (GO:0021533)2.73837533
119reproductive system development (GO:0061458)2.73677830
120regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72690582
121smoothened signaling pathway (GO:0007224)2.71915447
122glial cell proliferation (GO:0014009)2.71769257
123regulation of neurotransmitter secretion (GO:0046928)2.71026371
124positive regulation of dendritic spine development (GO:0060999)2.70953443
125response to auditory stimulus (GO:0010996)2.70697672
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70369586
127negative regulation of organelle assembly (GO:1902116)2.70244805
128regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69301966
129regulation of synapse assembly (GO:0051963)2.69194224
130neuronal action potential propagation (GO:0019227)2.68662520
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.68660684
132regulation of postsynaptic membrane potential (GO:0060078)2.68650504
133regulation of synaptic vesicle transport (GO:1902803)2.68470498
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.68181772
135neuron projection extension (GO:1990138)2.67681261
136somite development (GO:0061053)2.67576633
137cerebral cortex neuron differentiation (GO:0021895)2.67321764
138cilium morphogenesis (GO:0060271)2.64028403
139neural tube formation (GO:0001841)2.60811194
140cornea development in camera-type eye (GO:0061303)2.58417747
141adult walking behavior (GO:0007628)2.57975184
142cell proliferation in forebrain (GO:0021846)2.53721378
143synaptic transmission, cholinergic (GO:0007271)2.51912919
144cerebral cortex cell migration (GO:0021795)2.51830827
145C4-dicarboxylate transport (GO:0015740)2.50814886
146glycerophospholipid catabolic process (GO:0046475)2.47797439
147axoneme assembly (GO:0035082)2.46580074
148forebrain neuron differentiation (GO:0021879)2.46302253
149negative regulation of oligodendrocyte differentiation (GO:0048715)2.46158023
150regulation of neurotransmitter uptake (GO:0051580)2.45905561
151sequestering of actin monomers (GO:0042989)2.45835664
152keratinocyte development (GO:0003334)2.44387832
153regulation of collateral sprouting (GO:0048670)2.42016803
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.40613916
155NADH dehydrogenase complex assembly (GO:0010257)2.40613916
156mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.40613916
157cochlea development (GO:0090102)2.40422963
158negative regulation of glial cell differentiation (GO:0045686)2.40263090
159inner ear receptor stereocilium organization (GO:0060122)2.40123510
160protein complex biogenesis (GO:0070271)2.40013394
161behavioral response to ethanol (GO:0048149)2.39919283
162neuron migration (GO:0001764)2.39362613
163neuronal stem cell maintenance (GO:0097150)2.38990807
164serotonin metabolic process (GO:0042428)2.38375148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95598882
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.04413263
3GBX2_23144817_ChIP-Seq_PC3_Human3.12267856
4AR_21572438_ChIP-Seq_LNCaP_Human2.87344395
5REST_21632747_ChIP-Seq_MESCs_Mouse2.70011310
6VDR_22108803_ChIP-Seq_LS180_Human2.49548503
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37786394
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35271821
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34949648
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.33220676
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26608131
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.12379834
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10630220
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08537806
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08311601
16* RNF2_27304074_Chip-Seq_ESCs_Mouse2.05857409
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04460529
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02557229
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02557229
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99678346
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.97280742
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97229460
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94980310
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94876836
25FUS_26573619_Chip-Seq_HEK293_Human1.93119860
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92430022
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91925824
28ZNF274_21170338_ChIP-Seq_K562_Hela1.91270694
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89352853
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.88182469
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85103726
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.85103726
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83846943
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78983793
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.77472227
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75692247
37EWS_26573619_Chip-Seq_HEK293_Human1.75227436
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71250257
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.70897317
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68650502
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68384567
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65379976
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60612191
44DROSHA_22980978_ChIP-Seq_HELA_Human1.59453650
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.55211706
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51571233
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50471917
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49811545
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49063987
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45701130
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.43176842
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40911953
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.40446345
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39698693
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37777534
56RNF2_27304074_Chip-Seq_NSC_Mouse1.37580970
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37387528
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37138583
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36938916
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36938356
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36056818
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33438268
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31251829
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30646412
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30237505
66P300_19829295_ChIP-Seq_ESCs_Human1.29315934
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28077569
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27787031
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27474087
70IRF1_19129219_ChIP-ChIP_H3396_Human1.26172415
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23145839
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22667317
73BCAT_22108803_ChIP-Seq_LS180_Human1.22466400
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22355396
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20854502
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.19703510
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19682299
78CBP_20019798_ChIP-Seq_JUKART_Human1.19682299
79* FLI1_21867929_ChIP-Seq_TH2_Mouse1.19615647
80* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18593350
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18508276
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18206912
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17705523
84TAF15_26573619_Chip-Seq_HEK293_Human1.17103366
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17014187
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.16267962
87* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15500151
88TCF4_22108803_ChIP-Seq_LS180_Human1.12719935
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10234708
90* AR_25329375_ChIP-Seq_VCAP_Human1.07744570
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07684450
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07638535
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06820219
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06238627
95POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05640435
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.04951667
97* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04705747
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04131174
99AR_19668381_ChIP-Seq_PC3_Human1.03592269
100* NANOG_19829295_ChIP-Seq_ESCs_Human1.02991217
101* SOX2_19829295_ChIP-Seq_ESCs_Human1.02991217
102KDM2B_26808549_Chip-Seq_K562_Human1.01410362
103TCF4_23295773_ChIP-Seq_U87_Human1.00894627
104NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00527718
105SOX9_26525672_Chip-Seq_HEART_Mouse1.00406241
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00119839
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99971430
108TP53_22573176_ChIP-Seq_HFKS_Human0.99840983
109ER_23166858_ChIP-Seq_MCF-7_Human0.96727993
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.95809009
111* STAT3_23295773_ChIP-Seq_U87_Human0.93839842
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93041496
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92572569
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.92548580
115* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92243892
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92060365
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.90280928
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89336127
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89148745
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89118902
121IGF1R_20145208_ChIP-Seq_DFB_Human0.88954454
122GF1B_26923725_Chip-Seq_HPCs_Mouse0.88918908
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.88251226
124WDR5_24793694_ChIP-Seq_LNCAP_Human0.87851244
125KDM2B_26808549_Chip-Seq_REH_Human0.87448879
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.87264266
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.87197254
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.85892276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.55671762
2MP0003880_abnormal_central_pattern4.05074253
3MP0005409_darkened_coat_color3.58235855
4MP0009046_muscle_twitch3.46908327
5MP0004270_analgesia3.28628238
6MP0003136_yellow_coat_color3.21217802
7MP0003635_abnormal_synaptic_transmissio3.15997392
8MP0000778_abnormal_nervous_system3.12726211
9MP0005423_abnormal_somatic_nervous2.76019968
10MP0001984_abnormal_olfaction2.68959494
11MP0002063_abnormal_learning/memory/cond2.64629279
12MP0002184_abnormal_innervation2.61047254
13MP0002734_abnormal_mechanical_nocicepti2.44688792
14MP0006276_abnormal_autonomic_nervous2.37688343
15MP0009745_abnormal_behavioral_response2.36848483
16MP0002064_seizures2.36037450
17MP0001968_abnormal_touch/_nociception2.27598349
18MP0002572_abnormal_emotion/affect_behav2.26898656
19MP0002735_abnormal_chemical_nociception2.14515250
20MP0008877_abnormal_DNA_methylation2.14109477
21MP0003122_maternal_imprinting2.08635767
22MP0003787_abnormal_imprinting2.05409245
23MP0000015_abnormal_ear_pigmentation2.04162223
24MP0002733_abnormal_thermal_nociception2.03242616
25MP0004811_abnormal_neuron_physiology2.02780454
26MP0005394_taste/olfaction_phenotype2.01041639
27MP0005499_abnormal_olfactory_system2.01041639
28MP0001529_abnormal_vocalization2.00442938
29MP0001486_abnormal_startle_reflex1.98299928
30MP0000955_abnormal_spinal_cord1.97930958
31MP0008789_abnormal_olfactory_epithelium1.97323465
32MP0004858_abnormal_nervous_system1.94899948
33MP0002557_abnormal_social/conspecific_i1.92814736
34MP0006292_abnormal_olfactory_placode1.90913831
35MP0000566_synostosis1.89528189
36MP0002736_abnormal_nociception_after1.83485846
37MP0001440_abnormal_grooming_behavior1.78316330
38MP0002067_abnormal_sensory_capabilities1.75481723
39MP0002653_abnormal_ependyma_morphology1.71743877
40MP0005645_abnormal_hypothalamus_physiol1.71474758
41MP0002272_abnormal_nervous_system1.71094429
42MP0005410_abnormal_fertilization1.65906401
43MP0005646_abnormal_pituitary_gland1.63236176
44MP0005174_abnormal_tail_pigmentation1.61213127
45MP0001970_abnormal_pain_threshold1.60998114
46MP0002152_abnormal_brain_morphology1.57164873
47MP0002882_abnormal_neuron_morphology1.56647976
48MP0003121_genomic_imprinting1.55452759
49MP0003329_amyloid_beta_deposits1.54849516
50MP0005386_behavior/neurological_phenoty1.53453869
51MP0004924_abnormal_behavior1.53453869
52MP0009780_abnormal_chondrocyte_physiolo1.49599425
53MP0003632_abnormal_nervous_system1.46237286
54MP0002638_abnormal_pupillary_reflex1.43470435
55MP0002102_abnormal_ear_morphology1.42947588
56MP0002938_white_spotting1.39534051
57MP0004133_heterotaxia1.37371013
58MP0000631_abnormal_neuroendocrine_gland1.36663419
59MP0003861_abnormal_nervous_system1.34273257
60MP0006072_abnormal_retinal_apoptosis1.32981170
61MP0005253_abnormal_eye_physiology1.32754628
62MP0004742_abnormal_vestibular_system1.32724180
63MP0001485_abnormal_pinna_reflex1.31623132
64MP0005171_absent_coat_pigmentation1.30992286
65MP0008569_lethality_at_weaning1.29866661
66MP0002066_abnormal_motor_capabilities/c1.27423353
67MP0004142_abnormal_muscle_tone1.26656949
68MP0001188_hyperpigmentation1.25233170
69MP0003890_abnormal_embryonic-extraembry1.24470570
70MP0003011_delayed_dark_adaptation1.22390156
71MP0004147_increased_porphyrin_level1.20017813
72MP0002822_catalepsy1.18786370
73MP0003698_abnormal_male_reproductive1.16413587
74MP0002752_abnormal_somatic_nervous1.15853058
75MP0002090_abnormal_vision1.13391051
76MP0001501_abnormal_sleep_pattern1.12203796
77MP0003938_abnormal_ear_development1.10739163
78MP0004130_abnormal_muscle_cell1.08133137
79MP0000372_irregular_coat_pigmentation1.07888192
80MP0009379_abnormal_foot_pigmentation1.06449538
81MP0001299_abnormal_eye_distance/1.05502872
82MP0000569_abnormal_digit_pigmentation1.04130325
83MP0002069_abnormal_eating/drinking_beha1.03838721
84MP0005195_abnormal_posterior_eye1.02765468
85MP0005377_hearing/vestibular/ear_phenot1.01939392
86MP0003878_abnormal_ear_physiology1.01939392
87MP0004885_abnormal_endolymph1.01639887
88MP0002234_abnormal_pharynx_morphology0.97031013
89MP0002229_neurodegeneration0.95771878
90MP0003937_abnormal_limbs/digits/tail_de0.95109590
91MP0000647_abnormal_sebaceous_gland0.94871125
92MP0003631_nervous_system_phenotype0.94849110
93MP0000026_abnormal_inner_ear0.93711165
94MP0003195_calcinosis0.93273926
95MP0005248_abnormal_Harderian_gland0.91092432
96MP0002751_abnormal_autonomic_nervous0.90873751
97MP0002909_abnormal_adrenal_gland0.90523706
98MP0005187_abnormal_penis_morphology0.89028580
99MP0001929_abnormal_gametogenesis0.88706027
100MP0000747_muscle_weakness0.87949754
101MP0003755_abnormal_palate_morphology0.85208287
102MP0002928_abnormal_bile_duct0.84730907
103MP0001324_abnormal_eye_pigmentation0.84377485
104MP0001502_abnormal_circadian_rhythm0.81428541
105MP0001293_anophthalmia0.81182499
106MP0002095_abnormal_skin_pigmentation0.78393661
107MP0002249_abnormal_larynx_morphology0.77516573
108MP0003567_abnormal_fetal_cardiomyocyte0.75406267
109MP0004145_abnormal_muscle_electrophysio0.73778887
110MP0005535_abnormal_body_temperature0.73213596
111MP0002177_abnormal_outer_ear0.72099459
112MP0001963_abnormal_hearing_physiology0.71557503
113MP0001905_abnormal_dopamine_level0.70946611
114MP0003634_abnormal_glial_cell0.70786341
115MP0002233_abnormal_nose_morphology0.70606573
116MP0001664_abnormal_digestion0.70082764
117MP0002081_perinatal_lethality0.67660303
118MP0001177_atelectasis0.67582147
119MP0001943_abnormal_respiration0.67339712
120MP0000538_abnormal_urinary_bladder0.66322576
121MP0000049_abnormal_middle_ear0.65383806
122MP0004233_abnormal_muscle_weight0.65014065
123MP0000428_abnormal_craniofacial_morphol0.64257913
124MP0010386_abnormal_urinary_bladder0.62794101
125MP0002161_abnormal_fertility/fecundity0.61714743
126MP0002082_postnatal_lethality0.61690547
127MP0010770_preweaning_lethality0.61690547
128MP0003137_abnormal_impulse_conducting0.61394079
129MP0003879_abnormal_hair_cell0.60913709
130MP0000604_amyloidosis0.60676736
131MP0010769_abnormal_survival0.60385743
132MP0002210_abnormal_sex_determination0.59670237
133MP0005551_abnormal_eye_electrophysiolog0.59410124
134MP0000537_abnormal_urethra_morphology0.58653181
135MP0008872_abnormal_physiological_respon0.58454007

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)7.16257710
2Elfin facies (HP:0004428)7.05352550
3Overriding aorta (HP:0002623)6.89221458
4Renovascular hypertension (HP:0100817)6.52106023
5Insomnia (HP:0100785)6.30047520
6Sensory axonal neuropathy (HP:0003390)6.07178787
7Renal duplication (HP:0000075)5.78303405
8Toxemia of pregnancy (HP:0100603)5.64135765
9Flat cornea (HP:0007720)5.60904503
10Abnormality of the diencephalon (HP:0010662)4.73174391
11Polygenic inheritance (HP:0010982)4.71737955
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.61597100
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.36139519
14Absent/shortened dynein arms (HP:0200106)4.15753022
15Dynein arm defect of respiratory motile cilia (HP:0012255)4.15753022
16Abnormal respiratory motile cilium physiology (HP:0012261)3.87036680
17Curly hair (HP:0002212)3.85302544
18Abnormal respiratory motile cilium morphology (HP:0005938)3.75329095
19Abnormal respiratory epithelium morphology (HP:0012253)3.75329095
20Bladder diverticulum (HP:0000015)3.58511878
21Bowel diverticulosis (HP:0005222)3.56526358
22Rhinitis (HP:0012384)3.51582861
23Increased nuchal translucency (HP:0010880)3.45921278
24Morphological abnormality of the pyramidal tract (HP:0002062)3.29616855
25Megalocornea (HP:0000485)3.29515379
26Megalencephaly (HP:0001355)3.27992110
27True hermaphroditism (HP:0010459)3.24492301
28Myokymia (HP:0002411)3.23418116
29Pancreatic fibrosis (HP:0100732)3.23289575
30Molar tooth sign on MRI (HP:0002419)3.22716409
31Abnormality of midbrain morphology (HP:0002418)3.22716409
32Truncal ataxia (HP:0002078)3.21985854
33Congenital primary aphakia (HP:0007707)3.16924075
34Pancreatic cysts (HP:0001737)3.09776816
35Progressive cerebellar ataxia (HP:0002073)3.05300496
36Abnormal ciliary motility (HP:0012262)3.02009356
37Nephrogenic diabetes insipidus (HP:0009806)3.01052027
38Hyporeflexia of lower limbs (HP:0002600)2.95581645
39Pointed chin (HP:0000307)2.90595664
40Abnormality of the labia minora (HP:0012880)2.85980759
41Type II lissencephaly (HP:0007260)2.84008411
42Patellar dislocation (HP:0002999)2.82568772
43Genital tract atresia (HP:0001827)2.81912879
44Focal seizures (HP:0007359)2.76011307
45Vaginal atresia (HP:0000148)2.72775137
46Hypercalcemia (HP:0003072)2.65394522
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.65156767
48Obsessive-compulsive behavior (HP:0000722)2.61298737
49Optic nerve hypoplasia (HP:0000609)2.60789703
50Abnormality of the renal medulla (HP:0100957)2.56098392
51Oligodactyly (hands) (HP:0001180)2.54672521
52Amyotrophic lateral sclerosis (HP:0007354)2.53398769
53Hyperglycinemia (HP:0002154)2.52504089
54Hypercalciuria (HP:0002150)2.51576586
55Short tibia (HP:0005736)2.50884381
56Periorbital edema (HP:0100539)2.49751818
57Multifactorial inheritance (HP:0001426)2.49361541
58Arnold-Chiari malformation (HP:0002308)2.44272882
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.42773482
60Septo-optic dysplasia (HP:0100842)2.41281794
61Chronic bronchitis (HP:0004469)2.38547688
62Facial edema (HP:0000282)2.38282388
63Poor coordination (HP:0002370)2.37676639
64Specific learning disability (HP:0001328)2.36662778
65Visual hallucinations (HP:0002367)2.33671329
66Limb dystonia (HP:0002451)2.33389255
67Focal motor seizures (HP:0011153)2.32873331
68Anosmia (HP:0000458)2.31626159
69Sacral dimple (HP:0000960)2.29756705
70Colon cancer (HP:0003003)2.29671487
71Epileptic encephalopathy (HP:0200134)2.27222355
72Abnormality of the carotid arteries (HP:0005344)2.25457994
73Sclerocornea (HP:0000647)2.25290446
74Gait imbalance (HP:0002141)2.23222190
75Supranuclear gaze palsy (HP:0000605)2.23062242
76Genetic anticipation (HP:0003743)2.21982170
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20900280
78Short 4th metacarpal (HP:0010044)2.20900280
79Hypoplastic toenails (HP:0001800)2.20764519
80Postaxial hand polydactyly (HP:0001162)2.19942794
81Generalized myoclonic seizures (HP:0002123)2.19924512
82Lissencephaly (HP:0001339)2.19208099
83Cerebellar dysplasia (HP:0007033)2.18646353
84Polyphagia (HP:0002591)2.14978523
85Chronic sinusitis (HP:0011109)2.14714746
86Broad foot (HP:0001769)2.11916266
87Steppage gait (HP:0003376)2.10570848
88Precocious puberty (HP:0000826)2.10448606
89Adducted thumb (HP:0001181)2.10345558
90Decreased central vision (HP:0007663)2.09906439
91Hallux valgus (HP:0001822)2.09847614
92Ankyloglossia (HP:0010296)2.09175068
93Chronic hepatic failure (HP:0100626)2.08078647
94Cystic liver disease (HP:0006706)2.05744558
95Posterior embryotoxon (HP:0000627)2.04808360
96Paraplegia (HP:0010550)2.04578957
97Anencephaly (HP:0002323)2.03606882
98Febrile seizures (HP:0002373)2.03601096
99Poor suck (HP:0002033)2.01339389
100Dialeptic seizures (HP:0011146)2.00262028
101Postaxial foot polydactyly (HP:0001830)2.00065666
102Agitation (HP:0000713)1.99930833
103Congenital stationary night blindness (HP:0007642)1.99847801
104Pachygyria (HP:0001302)1.99567040
105Abnormality of the corticospinal tract (HP:0002492)1.99041786
106Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.98275424
107Spastic paraplegia (HP:0001258)1.98133402
108Abnormal eating behavior (HP:0100738)1.98113323
109Abnormality of the line of Schwalbe (HP:0008048)1.97791731
110Atonic seizures (HP:0010819)1.96673919
111Action tremor (HP:0002345)1.95685486
112Progressive inability to walk (HP:0002505)1.95641343
113Deviation of the hallux (HP:0010051)1.95224718
114Aplasia/Hypoplasia of the lens (HP:0008063)1.94907333
115Hypoplasia of the brainstem (HP:0002365)1.94105089
116Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94105089
117Split foot (HP:0001839)1.93389905
118Brushfield spots (HP:0001088)1.92465026
119Areflexia of lower limbs (HP:0002522)1.92250275
120Retinal dysplasia (HP:0007973)1.90778754
121Inability to walk (HP:0002540)1.90678408
122Spina bifida occulta (HP:0003298)1.89572338
123Broad-based gait (HP:0002136)1.88525387
124Drooling (HP:0002307)1.86702371
125Excessive salivation (HP:0003781)1.86702371
126Amblyopia (HP:0000646)1.86679026
127EEG with generalized epileptiform discharges (HP:0011198)1.86632038
128Hyperventilation (HP:0002883)1.86474290
129Urinary urgency (HP:0000012)1.86325524
130Hypsarrhythmia (HP:0002521)1.85741446
131Abolished electroretinogram (ERG) (HP:0000550)1.85640139
132Abnormality of the gastric mucosa (HP:0004295)1.85630400
133Fibular hypoplasia (HP:0003038)1.85482375
134Abnormality of the 4th metacarpal (HP:0010012)1.85339881
135Hemiparesis (HP:0001269)1.85294606
136Medial flaring of the eyebrow (HP:0010747)1.85209795
137Epileptiform EEG discharges (HP:0011182)1.84728535
138Nephronophthisis (HP:0000090)1.84032020
139Abnormality of the renal cortex (HP:0011035)1.83474730
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.83439193
141Oligodactyly (HP:0012165)1.83401333
142Concave nail (HP:0001598)1.82809116
143Abnormality of the lower motor neuron (HP:0002366)1.82546521
144Ankle clonus (HP:0011448)1.81254100
145Intestinal atresia (HP:0011100)1.80844989
146Acute necrotizing encephalopathy (HP:0006965)1.80591030
147Tubular atrophy (HP:0000092)1.78485353
148Decreased testicular size (HP:0008734)1.78020303
149Abnormality of glycine metabolism (HP:0010895)1.76980333
150Abnormality of serine family amino acid metabolism (HP:0010894)1.76980333
151Attenuation of retinal blood vessels (HP:0007843)1.76957886
152Spastic tetraplegia (HP:0002510)1.76503528
153Hypoplasia of the corpus callosum (HP:0002079)1.76226112
154Autism (HP:0000717)1.75467627
155Facial hemangioma (HP:0000329)1.74367599
156Generalized tonic-clonic seizures (HP:0002069)1.73622599
157Mutism (HP:0002300)1.73288795
158Preaxial hand polydactyly (HP:0001177)1.71110694
159Impaired vibration sensation in the lower limbs (HP:0002166)1.70226001
160Prominent nasal bridge (HP:0000426)1.69046832
161Aganglionic megacolon (HP:0002251)1.68133771
162Hyperglycinuria (HP:0003108)1.67394825
163Cortical dysplasia (HP:0002539)1.67003189
164Increased corneal curvature (HP:0100692)1.66346706
165Keratoconus (HP:0000563)1.66346706
166Hepatoblastoma (HP:0002884)1.66091541
167Multicystic kidney dysplasia (HP:0000003)1.66062778
168Absence seizures (HP:0002121)1.65903045
169Short foot (HP:0001773)1.64127713
170Hypoplasia of the ulna (HP:0003022)1.64007598
171Narrow forehead (HP:0000341)1.63575541
172Hip dysplasia (HP:0001385)1.63227876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.71474803
2MAP3K94.98355173
3NTRK22.94754753
4NTRK32.90056875
5MAP4K22.74920870
6FRK2.74506693
7PDK32.73986416
8PDK42.73986416
9YES12.49918495
10MINK12.46277872
11MAP3K42.45589767
12EPHA42.30696216
13SIK22.12715815
14MAPK132.07328377
15CASK2.06733741
16PHKG11.94813267
17PHKG21.94813267
18MAP2K71.93601746
19DYRK21.92886827
20ERBB31.91819676
21INSRR1.91235556
22PINK11.80743815
23LMTK21.61520755
24TNIK1.60881248
25CCNB11.47810182
26ZAK1.45764225
27ADRBK21.45043574
28TRIM281.43218477
29BCKDK1.42927323
30UHMK11.38556619
31PRPF4B1.35641530
32NUAK11.33475805
33WNK41.29937625
34PDK21.26341675
35PDGFRB1.24792606
36MAP2K41.23257831
37KSR11.21415512
38NTRK11.19215443
39PAK61.14917888
40STK391.14680219
41ICK1.14514552
42MAPK151.11888821
43BMPR1B1.09210989
44GRK11.08948340
45PAK31.07876362
46SGK2231.04741549
47SGK4941.04741549
48CDK51.02697394
49MKNK21.02354585
50MAP3K121.01948897
51EPHA31.01362435
52PNCK0.99547331
53MKNK10.97417354
54PRKCG0.96823872
55DYRK30.94820273
56PLK20.90373475
57TYRO30.90367459
58LATS20.88650034
59EPHB20.88222978
60DAPK20.87042924
61TAOK30.86519806
62NME10.85075563
63OXSR10.84666347
64DYRK1A0.84471924
65PRKCE0.83593132
66SIK30.83385220
67GRK50.82979970
68SGK20.82791520
69TSSK60.80377818
70TAOK10.79561872
71TNK20.77760096
72CSNK1G20.73079291
73PKN10.72603867
74PRKD30.72377018
75MARK20.71119443
76LIMK10.70667770
77VRK10.68852737
78PRKCZ0.68694297
79PLK30.67583134
80SRPK10.67509295
81CAMKK10.67276860
82CDK140.66942470
83PLK40.66581115
84CDK180.65839141
85TGFBR10.62644550
86STK110.61465056
87CAMK2A0.60713611
88CDK150.60551262
89CAMK10.60373463
90FER0.58015420
91FYN0.56217615
92DYRK1B0.56124232
93BCR0.55313203
94PRKG10.54924485
95ERBB40.54601271
96FGR0.53197063
97CSNK1A10.53057043
98ACVR1B0.52515714
99MAPKAPK50.51249827
100WNK30.51239936
101CSNK1G30.51022744
102IRAK20.50832050
103CAMK2B0.50338472
104HCK0.49277204
105RPS6KA20.49221143
106WEE10.48668812
107STK38L0.48646672
108MAP3K20.48524060
109SGK10.47546191
110PRKACA0.47112248
111SGK30.46755214
112CDK11A0.46643044
113PLK10.46217914
114RIPK10.45957575
115EGFR0.45701870
116MAPK100.42753999
117ROCK10.42714109
118RPS6KA40.40852520
119CAMKK20.40191179
120AKT30.40046132
121NEK20.39479533
122ERBB20.39462449
123CAMK40.39344985
124NEK60.38682606
125CAMK2D0.38653740
126CSNK1G10.38398288
127CSNK1D0.38211640
128CSNK1A1L0.37661769
129DMPK0.36816096
130CDK30.36651695
131FGFR20.35899973
132CDK190.35612553
133TIE10.35518949
134PIK3CA0.35354142
135PRKCI0.33604980
136ADRBK10.33041869
137FES0.30598186
138INSR0.28396434
139RET0.27666236
140DDR20.27307902
141GRK60.27081367
142MAPK90.27018133
143PRKACG0.25761642
144DAPK10.24982023

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60747704
2Olfactory transduction_Homo sapiens_hsa047402.65848807
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60927155
4Glutamatergic synapse_Homo sapiens_hsa047242.52533145
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44217660
6Circadian entrainment_Homo sapiens_hsa047132.35609642
7Synaptic vesicle cycle_Homo sapiens_hsa047212.29319700
8Morphine addiction_Homo sapiens_hsa050322.09670280
9GABAergic synapse_Homo sapiens_hsa047272.08739127
10Oxidative phosphorylation_Homo sapiens_hsa001902.06520033
11Long-term potentiation_Homo sapiens_hsa047202.05295794
12Dopaminergic synapse_Homo sapiens_hsa047282.05007624
13Axon guidance_Homo sapiens_hsa043602.00023779
14Protein export_Homo sapiens_hsa030601.96670850
15ErbB signaling pathway_Homo sapiens_hsa040121.92426080
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90145833
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89984405
18Linoleic acid metabolism_Homo sapiens_hsa005911.87380990
19Taste transduction_Homo sapiens_hsa047421.86271750
20Nitrogen metabolism_Homo sapiens_hsa009101.85383969
21Long-term depression_Homo sapiens_hsa047301.76106922
22Serotonergic synapse_Homo sapiens_hsa047261.75323159
23Amphetamine addiction_Homo sapiens_hsa050311.74196524
24Cholinergic synapse_Homo sapiens_hsa047251.70977149
25Parkinsons disease_Homo sapiens_hsa050121.68763999
26Pentose phosphate pathway_Homo sapiens_hsa000301.67506205
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60805606
28Dorso-ventral axis formation_Homo sapiens_hsa043201.60716723
29Propanoate metabolism_Homo sapiens_hsa006401.55459280
30Gap junction_Homo sapiens_hsa045401.54230956
31Insulin secretion_Homo sapiens_hsa049111.53907382
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50412363
33Salivary secretion_Homo sapiens_hsa049701.49762281
34Fanconi anemia pathway_Homo sapiens_hsa034601.45112460
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42180766
36Steroid biosynthesis_Homo sapiens_hsa001001.38964347
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37526962
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36692147
39* Gastric acid secretion_Homo sapiens_hsa049711.36070894
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35970984
41Butanoate metabolism_Homo sapiens_hsa006501.35892878
42Renin secretion_Homo sapiens_hsa049241.35546841
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31947984
44Oxytocin signaling pathway_Homo sapiens_hsa049211.30209268
45Cocaine addiction_Homo sapiens_hsa050301.29423171
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26473224
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24357508
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23171402
49Peroxisome_Homo sapiens_hsa041461.22894040
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21340875
51GnRH signaling pathway_Homo sapiens_hsa049121.18063378
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08804007
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.07101221
54Alcoholism_Homo sapiens_hsa050341.06646992
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05553014
56Tryptophan metabolism_Homo sapiens_hsa003801.05490333
57Calcium signaling pathway_Homo sapiens_hsa040201.05118820
58Melanogenesis_Homo sapiens_hsa049161.03744363
59Estrogen signaling pathway_Homo sapiens_hsa049151.03370031
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02375578
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99533862
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97501454
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.96806761
64RNA degradation_Homo sapiens_hsa030180.93854901
65Glioma_Homo sapiens_hsa052140.93345281
66Type II diabetes mellitus_Homo sapiens_hsa049300.92627184
67Oocyte meiosis_Homo sapiens_hsa041140.91929344
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90913274
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.89927929
70beta-Alanine metabolism_Homo sapiens_hsa004100.86511663
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85763115
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85752906
73Cardiac muscle contraction_Homo sapiens_hsa042600.83414981
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83227048
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.83044309
76Fatty acid biosynthesis_Homo sapiens_hsa000610.82672519
77cAMP signaling pathway_Homo sapiens_hsa040240.82541063
78Basal transcription factors_Homo sapiens_hsa030220.81287785
79Endometrial cancer_Homo sapiens_hsa052130.80609009
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.80097133
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80083261
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79942854
83Renal cell carcinoma_Homo sapiens_hsa052110.79846028
84Selenocompound metabolism_Homo sapiens_hsa004500.79586913
85Insulin signaling pathway_Homo sapiens_hsa049100.77441410
86Regulation of autophagy_Homo sapiens_hsa041400.73933876
87Choline metabolism in cancer_Homo sapiens_hsa052310.69955767
88Arachidonic acid metabolism_Homo sapiens_hsa005900.69293930
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68356620
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65172798
91Collecting duct acid secretion_Homo sapiens_hsa049660.64686526
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63776220
93Glucagon signaling pathway_Homo sapiens_hsa049220.63377600
94MAPK signaling pathway_Homo sapiens_hsa040100.63359722
95Fat digestion and absorption_Homo sapiens_hsa049750.62897042
96Retinol metabolism_Homo sapiens_hsa008300.62685260
97Bile secretion_Homo sapiens_hsa049760.61802144
98Caffeine metabolism_Homo sapiens_hsa002320.60043996
99Hedgehog signaling pathway_Homo sapiens_hsa043400.59315355
100Wnt signaling pathway_Homo sapiens_hsa043100.58939615
101Chronic myeloid leukemia_Homo sapiens_hsa052200.58462422
102Ovarian steroidogenesis_Homo sapiens_hsa049130.58263951
103Homologous recombination_Homo sapiens_hsa034400.58103100
104Chemical carcinogenesis_Homo sapiens_hsa052040.57747023
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57710557
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.56740456
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56377657
108Basal cell carcinoma_Homo sapiens_hsa052170.55956103
109Colorectal cancer_Homo sapiens_hsa052100.55005070
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54228040
111Circadian rhythm_Homo sapiens_hsa047100.52151937
112Ribosome_Homo sapiens_hsa030100.51879950
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51814027
114Thyroid hormone synthesis_Homo sapiens_hsa049180.51179191
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50029568
116Fatty acid elongation_Homo sapiens_hsa000620.49315659
117Phenylalanine metabolism_Homo sapiens_hsa003600.46601355
118Metabolic pathways_Homo sapiens_hsa011000.46081130
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46071526
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46024553
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45803607
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.44324054
123Arginine and proline metabolism_Homo sapiens_hsa003300.42717332
124VEGF signaling pathway_Homo sapiens_hsa043700.42450297
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42366367
126Rap1 signaling pathway_Homo sapiens_hsa040150.41758271
127RNA polymerase_Homo sapiens_hsa030200.41100644
128N-Glycan biosynthesis_Homo sapiens_hsa005100.40327282
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40326109
130Fatty acid degradation_Homo sapiens_hsa000710.39583705
131Histidine metabolism_Homo sapiens_hsa003400.38908179
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38436754
133Ras signaling pathway_Homo sapiens_hsa040140.38435368
134Glycerolipid metabolism_Homo sapiens_hsa005610.37513977
135Hippo signaling pathway_Homo sapiens_hsa043900.37275238
136Lysine degradation_Homo sapiens_hsa003100.34210848
137Fatty acid metabolism_Homo sapiens_hsa012120.33080946
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.32692246
139AMPK signaling pathway_Homo sapiens_hsa041520.32308707
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32257045
141Endocytosis_Homo sapiens_hsa041440.32172421
142Systemic lupus erythematosus_Homo sapiens_hsa053220.31906302
143Alzheimers disease_Homo sapiens_hsa050100.31279075
144Pancreatic secretion_Homo sapiens_hsa049720.30812846
145Ether lipid metabolism_Homo sapiens_hsa005650.30769021
146Huntingtons disease_Homo sapiens_hsa050160.30094554
147Phototransduction_Homo sapiens_hsa047440.29754837

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