KCNK12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)8.62116236
2synaptic vesicle docking involved in exocytosis (GO:0016081)8.15602789
3DNA deamination (GO:0045006)7.22419218
4regulation of short-term neuronal synaptic plasticity (GO:0048172)7.04983127
5glutamate secretion (GO:0014047)7.04491383
6sodium ion export (GO:0071436)6.90126752
7synaptic vesicle exocytosis (GO:0016079)6.80771541
8cellular potassium ion homeostasis (GO:0030007)6.51598130
9regulation of synaptic vesicle exocytosis (GO:2000300)6.42098467
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.14324173
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.93164100
12ribosomal small subunit assembly (GO:0000028)5.93073641
13neurotransmitter secretion (GO:0007269)5.83365417
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51813175
15regulation of synaptic vesicle transport (GO:1902803)5.50375158
16locomotory exploration behavior (GO:0035641)5.38415075
17antigen processing and presentation via MHC class Ib (GO:0002475)5.32482467
18positive regulation of synapse maturation (GO:0090129)5.06755541
19regulation of neuronal synaptic plasticity (GO:0048168)5.03103855
20vocalization behavior (GO:0071625)4.99739388
21neuronal action potential propagation (GO:0019227)4.97737004
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.93731105
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91689673
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.84777832
25exploration behavior (GO:0035640)4.83357159
26viral transcription (GO:0019083)4.80241554
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.74306266
28L-amino acid import (GO:0043092)4.68258030
29cerebellar granule cell differentiation (GO:0021707)4.67019474
30neurotransmitter transport (GO:0006836)4.63280598
31translational termination (GO:0006415)4.58416235
32synaptic transmission, glutamatergic (GO:0035249)4.51757795
33negative regulation of phagocytosis (GO:0050765)4.47423401
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45711980
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45711980
36telomere maintenance via semi-conservative replication (GO:0032201)4.44482486
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.40900251
38potassium ion homeostasis (GO:0055075)4.38646584
39killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.35807748
40disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.35807748
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35413973
42regulation of long-term neuronal synaptic plasticity (GO:0048169)4.33493693
43cotranslational protein targeting to membrane (GO:0006613)4.29633138
44regulation of neurotransmitter secretion (GO:0046928)4.29299007
45cell communication by electrical coupling (GO:0010644)4.28985154
46amino acid import (GO:0043090)4.28148057
47translational elongation (GO:0006414)4.27419891
48protein targeting to ER (GO:0045047)4.26626919
49cerebellar Purkinje cell differentiation (GO:0021702)4.26484217
50negative regulation of synaptic transmission, GABAergic (GO:0032229)4.26381994
51protein localization to synapse (GO:0035418)4.24589512
52regulation of neurotransmitter levels (GO:0001505)4.18801057
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18699162
54positive regulation of membrane potential (GO:0045838)4.18075646
55neutrophil mediated immunity (GO:0002446)4.18055188
56regulation of excitatory postsynaptic membrane potential (GO:0060079)4.16601045
57regulation of glutamate receptor signaling pathway (GO:1900449)4.12009592
58protein localization to endoplasmic reticulum (GO:0070972)4.09990935
59neuromuscular process controlling posture (GO:0050884)4.09757290
60establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06825366
61DNA strand elongation involved in DNA replication (GO:0006271)4.06221027
62neuronal ion channel clustering (GO:0045161)4.02453631
63neuron-neuron synaptic transmission (GO:0007270)4.01138018
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.98886144
65potassium ion import (GO:0010107)3.98282147
66negative regulation of erythrocyte differentiation (GO:0045647)3.96410178
67positive regulation of B cell differentiation (GO:0045579)3.96141314
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.95368427
69lymphoid progenitor cell differentiation (GO:0002320)3.95245468
70layer formation in cerebral cortex (GO:0021819)3.94690533
71myeloid leukocyte mediated immunity (GO:0002444)3.94164242
72neuron cell-cell adhesion (GO:0007158)3.93680114
73neuromuscular process controlling balance (GO:0050885)3.90566416
74glutamate receptor signaling pathway (GO:0007215)3.88743983
75DNA strand elongation (GO:0022616)3.85951382
76regulation of postsynaptic membrane potential (GO:0060078)3.84278590
77regulation of neurotransmitter transport (GO:0051588)3.82724861
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.82003692
79cellular sodium ion homeostasis (GO:0006883)3.81877444
80regulation of synapse maturation (GO:0090128)3.81312650
81gamma-aminobutyric acid transport (GO:0015812)3.80685238
82regulation of synaptic plasticity (GO:0048167)3.79360673
83axon ensheathment in central nervous system (GO:0032291)3.78990427
84central nervous system myelination (GO:0022010)3.78990427
85ribosomal small subunit biogenesis (GO:0042274)3.74971158
86regulation of vesicle fusion (GO:0031338)3.71285396
87L-fucose catabolic process (GO:0042355)3.68107010
88fucose catabolic process (GO:0019317)3.68107010
89L-fucose metabolic process (GO:0042354)3.68107010
90platelet dense granule organization (GO:0060155)3.67609964
91proline transport (GO:0015824)3.67231260
92postsynaptic membrane organization (GO:0001941)3.67094057
93neurotransmitter-gated ion channel clustering (GO:0072578)3.64703942
94positive regulation of dendritic spine development (GO:0060999)3.64159316
95positive regulation of neurotransmitter transport (GO:0051590)3.59217310
96long-term memory (GO:0007616)3.57111537
97positive regulation of neurotransmitter secretion (GO:0001956)3.53832465
98cellular protein complex disassembly (GO:0043624)3.53641241
99viral life cycle (GO:0019058)3.53489203
100negative regulation of transcription by competitive promoter binding (GO:0010944)3.51398567
101telomere maintenance via recombination (GO:0000722)3.50337926
102synaptic vesicle endocytosis (GO:0048488)3.50333890
103positive regulation of dendritic spine morphogenesis (GO:0061003)3.50267496
104maturation of SSU-rRNA (GO:0030490)3.48494640
105response to interferon-alpha (GO:0035455)3.47751687
106endosome to melanosome transport (GO:0035646)3.47091209
107endosome to pigment granule transport (GO:0043485)3.47091209
108macrophage differentiation (GO:0030225)3.45690448
109transmission of nerve impulse (GO:0019226)3.45028569
110membrane depolarization (GO:0051899)3.43765024
111dendritic spine morphogenesis (GO:0060997)3.43039903
112Arp2/3 complex-mediated actin nucleation (GO:0034314)3.41466225
113nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40758523
114negative regulation of dendrite morphogenesis (GO:0050774)3.40442265
115membrane depolarization during action potential (GO:0086010)3.39510703
116antigen processing and presentation of endogenous antigen (GO:0019883)3.39046967
117cell differentiation in hindbrain (GO:0021533)3.38722683
118positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36715487
119chemosensory behavior (GO:0007635)3.36365138
120regulation of synapse structural plasticity (GO:0051823)3.34889798
121translational initiation (GO:0006413)3.33675409
122pseudouridine synthesis (GO:0001522)3.33593953
123regulation of voltage-gated calcium channel activity (GO:1901385)3.32344585
124response to interferon-beta (GO:0035456)3.29626258
125neuromuscular synaptic transmission (GO:0007274)3.28912892
126acidic amino acid transport (GO:0015800)3.28265628
127pentose-phosphate shunt (GO:0006098)3.28155883
128immunoglobulin mediated immune response (GO:0016064)3.27463006
129synaptic transmission (GO:0007268)3.25822094
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.24623181
131neurotransmitter uptake (GO:0001504)3.23361281
132fucosylation (GO:0036065)3.22125678
133regulation of dendritic spine morphogenesis (GO:0061001)3.17886082
134DNA replication initiation (GO:0006270)3.17247389
135defense response to fungus (GO:0050832)3.16650685
136cell migration in hindbrain (GO:0021535)3.16644391
137protein complex disassembly (GO:0043241)3.16159570
138serotonin metabolic process (GO:0042428)3.13551318
139regulation of synaptic transmission (GO:0050804)3.13438645
140telomere maintenance via telomere lengthening (GO:0010833)3.13373308
141regulation of ARF protein signal transduction (GO:0032012)3.11642387
142regulation of female receptivity (GO:0045924)3.11384114
143negative regulation of myotube differentiation (GO:0010832)3.11015238
144behavioral fear response (GO:0001662)3.09987215
145behavioral defense response (GO:0002209)3.09987215
146presynaptic membrane organization (GO:0097090)3.09472989
147killing of cells of other organism (GO:0031640)3.08553355
148disruption of cells of other organism (GO:0044364)3.08553355
149regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.07326430
150cell communication involved in cardiac conduction (GO:0086065)3.06999586
151regulation of dendritic spine development (GO:0060998)3.06411728
152neuromuscular process (GO:0050905)3.05863161
153ribosomal large subunit biogenesis (GO:0042273)3.05479297
154necroptotic process (GO:0070266)3.05075742
155vesicle docking involved in exocytosis (GO:0006904)3.04012222
156membrane hyperpolarization (GO:0060081)3.03256184
157negative regulation of growth of symbiont in host (GO:0044130)3.02280455
158negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.02280455
159modulation of growth of symbiont involved in interaction with host (GO:0044144)3.02280455
160regulation of growth of symbiont in host (GO:0044126)3.02280455
161* cellular potassium ion transport (GO:0071804)3.01171184
162* potassium ion transmembrane transport (GO:0071805)3.01171184
163intraspecies interaction between organisms (GO:0051703)3.00591858
164macromolecular complex disassembly (GO:0032984)2.99628409
165defense response to protozoan (GO:0042832)2.98984878
166mitotic recombination (GO:0006312)2.97898259
167respiratory chain complex IV assembly (GO:0008535)2.96033568
168histone H2A acetylation (GO:0043968)2.94626797
169protein targeting to membrane (GO:0006612)2.94502311
170mast cell activation (GO:0045576)2.93975078
171GDP-mannose metabolic process (GO:0019673)2.89283373
172definitive hemopoiesis (GO:0060216)2.87018829
173protein maturation by protein folding (GO:0022417)2.87003964
174purine-containing compound salvage (GO:0043101)2.86967715
175regulation of necrotic cell death (GO:0010939)2.85844181
176regulation of B cell differentiation (GO:0045577)2.79159851
177regulation of erythrocyte differentiation (GO:0045646)2.75041464
178negative regulation of granulocyte differentiation (GO:0030853)2.74604669
179secretory granule organization (GO:0033363)2.73580885
180pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72935648
181response to protozoan (GO:0001562)2.72814728
182NADPH regeneration (GO:0006740)2.71224250
183B cell mediated immunity (GO:0019724)2.70133731
184DNA unwinding involved in DNA replication (GO:0006268)2.69623963
185negative regulation of RNA splicing (GO:0033119)2.64851876
186lipopolysaccharide biosynthetic process (GO:0009103)2.64423800
187regulation of histone phosphorylation (GO:0033127)2.64079290
188cellular response to zinc ion (GO:0071294)2.62883714
189response to fungus (GO:0009620)2.62229680
190translation (GO:0006412)2.62095260
191ribonucleoprotein complex biogenesis (GO:0022613)2.61841404
192translesion synthesis (GO:0019985)2.61165295
193cytokine production involved in immune response (GO:0002367)2.59935780
194nucleotide-excision repair, DNA gap filling (GO:0006297)2.59878051
195mast cell degranulation (GO:0043303)2.59314670
196mast cell activation involved in immune response (GO:0002279)2.59314670
197ncRNA 3-end processing (GO:0043628)2.56323225
198metallo-sulfur cluster assembly (GO:0031163)2.56176692
199iron-sulfur cluster assembly (GO:0016226)2.56176692
200actin nucleation (GO:0045010)2.53009737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.84517974
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97929744
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.60368496
4* REST_21632747_ChIP-Seq_MESCs_Mouse3.56961108
5SCL_19346495_ChIP-Seq_HPC-7_Human3.56011950
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.33046050
7* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.23816156
8VDR_21846776_ChIP-Seq_THP-1_Human3.21590813
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19863899
10RARB_27405468_Chip-Seq_BRAIN_Mouse3.18011007
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06997777
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.03513420
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02934000
14* REST_18959480_ChIP-ChIP_MESCs_Mouse3.02837513
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.97302573
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.97010336
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92333425
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.80450035
19DROSHA_22980978_ChIP-Seq_HELA_Human2.78930635
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.77173235
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73946659
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68225613
23* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68225613
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.67733016
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.66086001
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62179328
27GATA1_22025678_ChIP-Seq_K562_Human2.57760778
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.54946835
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.54870282
30* RNF2_27304074_Chip-Seq_ESCs_Mouse2.53591422
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52701807
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50093605
33MYC_22102868_ChIP-Seq_BL_Human2.47719805
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47177620
35* EZH2_27304074_Chip-Seq_ESCs_Mouse2.46571256
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.45639847
37SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45188319
38ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35490549
39MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33075601
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32760846
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29733403
42* RCOR3_21632747_ChIP-Seq_MESCs_Mouse2.27001857
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25556909
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.24927467
45ERG_20887958_ChIP-Seq_HPC-7_Mouse2.22968280
46ZFP281_18757296_ChIP-ChIP_E14_Mouse2.21357102
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20559085
48VDR_24763502_ChIP-Seq_THP-1_Human2.17720911
49* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13872763
50NOTCH1_21737748_ChIP-Seq_TLL_Human2.12050212
51* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09486655
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07378332
53ERG_21242973_ChIP-ChIP_JURKAT_Human2.03982732
54SPI1_23547873_ChIP-Seq_NB4_Human2.03303224
55IRF8_22096565_ChIP-ChIP_GC-B_Human2.02796702
56* EED_16625203_ChIP-ChIP_MESCs_Mouse2.01865525
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.99361809
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93769453
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.91256686
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.89189920
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.88309401
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85507233
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83112025
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81813431
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.81281173
66* RUNX1_22412390_ChIP-Seq_EML_Mouse1.81199151
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80428701
68GBX2_23144817_ChIP-Seq_PC3_Human1.79778631
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77280024
70VDR_23849224_ChIP-Seq_CD4+_Human1.71644095
71CIITA_25753668_ChIP-Seq_RAJI_Human1.70360119
72XRN2_22483619_ChIP-Seq_HELA_Human1.68892006
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67911132
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.64249718
75KDM2B_26808549_Chip-Seq_K562_Human1.63465529
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59405806
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.58814228
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57280297
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54993320
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54477099
81FOXP3_21729870_ChIP-Seq_TREG_Human1.50134565
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48366605
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47792121
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46581796
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46470446
86MAF_26560356_Chip-Seq_TH1_Human1.46295055
87TCF7_22412390_ChIP-Seq_EML_Mouse1.44316573
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44021189
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43925137
90* SPI1_23127762_ChIP-Seq_K562_Human1.43774313
91* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43645719
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43107601
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41110593
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.40215031
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39947343
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39595560
97AR_21572438_ChIP-Seq_LNCaP_Human1.38659652
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38476428
99LXR_22292898_ChIP-Seq_THP-1_Human1.37728058
100CTCF_27219007_Chip-Seq_Bcells_Human1.37285129
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37203847
102GABP_19822575_ChIP-Seq_HepG2_Human1.36800764
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35647140
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34709493
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34221364
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32699855
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32010770
108UTX_26944678_Chip-Seq_JUKART_Human1.31656764
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31576286
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.30631592
111THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29992818
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.29761757
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28815509
114MYB_26560356_Chip-Seq_TH2_Human1.28201677
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28142336
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.27893593
117EZH2_22144423_ChIP-Seq_EOC_Human1.27826633
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27510121
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26927885
120DCP1A_22483619_ChIP-Seq_HELA_Human1.25051292
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.24395703
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23288280
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22538840
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21333722
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21088692
126TET1_21490601_ChIP-Seq_MESCs_Mouse1.20848458
127PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20048057
128* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19283573
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18136799
130MYB_26560356_Chip-Seq_TH1_Human1.16214695
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15373613
132RNF2_27304074_Chip-Seq_NSC_Mouse1.15179866
133NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14698565
134BCL6_27268052_Chip-Seq_Bcells_Human1.14416193
135* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12790351
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12259180
137OCT4_19829295_ChIP-Seq_ESCs_Human1.11637627
138* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11194536
139* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10966130
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09537893
141* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08899886
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08446584
143DPY_21335234_ChIP-Seq_ESCs_Mouse1.08414193
144TTF2_22483619_ChIP-Seq_HELA_Human1.07351674
145EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07317650
146* AR_19668381_ChIP-Seq_PC3_Human1.05173741
147CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04562052
148GATA1_19941827_ChIP-Seq_MEL_Mouse1.03946309
149ELF1_20517297_ChIP-Seq_JURKAT_Human1.03567501
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03368641
151CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03275437
152GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01065163
153E2F1_21310950_ChIP-Seq_MCF-7_Human1.01012099
154MAF_26560356_Chip-Seq_TH2_Human0.99299338
155YY1_22570637_ChIP-Seq_MALME-3M_Human0.98508204
156IRF8_27001747_Chip-Seq_BMDM_Mouse0.98280937
157CREB1_26743006_Chip-Seq_LNCaP_Human0.97720590
158* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97380027
159PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97109598
160* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96610254
161SMC4_20622854_ChIP-Seq_HELA_Human0.94812519
162FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94269963
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.91916062
164SMAD4_21741376_ChIP-Seq_ESCs_Human0.91264041
165P68_20966046_ChIP-Seq_HELA_Human0.90695796
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90053992
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90053992
168LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88781511
169TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87420031
170BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86784304
171PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86707561
172NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85179366
173KDM2B_26808549_Chip-Seq_DND41_Human0.85033063
174TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83524144
175* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83504840
176CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82875564
177MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82516012
178TP53_20018659_ChIP-ChIP_R1E_Mouse0.82241135
179SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82043397
180CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81347065
181* SMAD3_21741376_ChIP-Seq_EPCs_Human0.81181437
182YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80840051
183TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80801174
184SMAD4_21741376_ChIP-Seq_HESCs_Human0.80300041
185SOX2_21211035_ChIP-Seq_LN229_Gbm0.78803418
186SMAD3_21741376_ChIP-Seq_ESCs_Human0.77662874
187NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75550518
188POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.75535439
189POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.74850132
190ISL1_27105846_Chip-Seq_CPCs_Mouse0.73459089
191SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71682737
192* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71124288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.92156866
2MP0002396_abnormal_hematopoietic_system4.09176451
3MP0002064_seizures3.48481938
4MP0005174_abnormal_tail_pigmentation3.32012855
5MP0009745_abnormal_behavioral_response3.27095556
6MP0005075_abnormal_melanosome_morpholog3.23547413
7MP0002063_abnormal_learning/memory/cond3.09992232
8MP0003172_abnormal_lysosome_physiology2.93735545
9MP0001986_abnormal_taste_sensitivity2.83081971
10MP0003303_peritoneal_inflammation2.69718432
11MP0001486_abnormal_startle_reflex2.60930078
12MP0002572_abnormal_emotion/affect_behav2.56598916
13MP0009379_abnormal_foot_pigmentation2.44772910
14MP0000015_abnormal_ear_pigmentation2.32240689
15MP0001835_abnormal_antigen_presentation2.31438273
16MP0003866_abnormal_defecation2.30772620
17MP0005464_abnormal_platelet_physiology2.29286392
18MP0003787_abnormal_imprinting2.26473920
19MP0010386_abnormal_urinary_bladder2.25978737
20MP0009785_altered_susceptibility_to2.22818463
21MP0003693_abnormal_embryo_hatching2.21381630
22MP0004808_abnormal_hematopoietic_stem2.14647134
23MP0005671_abnormal_response_to2.13507369
24MP0002095_abnormal_skin_pigmentation2.13279841
25MP0003183_abnormal_peptide_metabolism2.07735770
26MP0001968_abnormal_touch/_nociception2.07601182
27MP0002736_abnormal_nociception_after2.03632031
28MP0003436_decreased_susceptibility_to2.02012549
29MP0005397_hematopoietic_system_phenotyp2.00358822
30MP0001545_abnormal_hematopoietic_system2.00358822
31MP0004859_abnormal_synaptic_plasticity1.95626976
32MP0003724_increased_susceptibility_to1.94094859
33MP0005646_abnormal_pituitary_gland1.92496768
34MP0000490_abnormal_crypts_of1.89176112
35MP0005025_abnormal_response_to1.85876637
36MP0001501_abnormal_sleep_pattern1.85453094
37MP0002419_abnormal_innate_immunity1.85017936
38MP0000465_gastrointestinal_hemorrhage1.84013611
39MP0000685_abnormal_immune_system1.81739890
40MP0002398_abnormal_bone_marrow1.76080781
41MP0002067_abnormal_sensory_capabilities1.69976312
42MP0002735_abnormal_chemical_nociception1.69581559
43MP0001440_abnormal_grooming_behavior1.69439123
44MP0002420_abnormal_adaptive_immunity1.68842849
45MP0005058_abnormal_lysosome_morphology1.66418024
46MP0001819_abnormal_immune_cell1.64069626
47MP0003329_amyloid_beta_deposits1.62539810
48MP0004811_abnormal_neuron_physiology1.62314347
49MP0001853_heart_inflammation1.61571940
50MP0002723_abnormal_immune_serum1.57550996
51MP0000689_abnormal_spleen_morphology1.53847608
52MP0000716_abnormal_immune_system1.53627122
53MP0002557_abnormal_social/conspecific_i1.53205212
54MP0005000_abnormal_immune_tolerance1.52129663
55MP0004147_increased_porphyrin_level1.51841972
56MP0008877_abnormal_DNA_methylation1.48092403
57MP0008058_abnormal_DNA_repair1.47648172
58MP0008007_abnormal_cellular_replicative1.46623051
59MP0002148_abnormal_hypersensitivity_rea1.43012817
60MP0002722_abnormal_immune_system1.42739592
61MP0003122_maternal_imprinting1.41770041
62MP0002429_abnormal_blood_cell1.41668939
63MP0000778_abnormal_nervous_system1.40754507
64MP0010094_abnormal_chromosome_stability1.40408468
65MP0001188_hyperpigmentation1.40110533
66MP0003763_abnormal_thymus_physiology1.39791021
67MP0002066_abnormal_motor_capabilities/c1.38796363
68MP0001502_abnormal_circadian_rhythm1.38151895
69MP0002452_abnormal_antigen_presenting1.36976334
70MP0002733_abnormal_thermal_nociception1.35554372
71MP0006276_abnormal_autonomic_nervous1.34144587
72MP0003300_gastrointestinal_ulcer1.34042087
73MP0003656_abnormal_erythrocyte_physiolo1.33443780
74MP0003690_abnormal_glial_cell1.32360452
75MP0002184_abnormal_innervation1.31046030
76MP0003633_abnormal_nervous_system1.30384918
77MP0004924_abnormal_behavior1.30097457
78MP0005386_behavior/neurological_phenoty1.30097457
79MP0001970_abnormal_pain_threshold1.26098633
80MP0002882_abnormal_neuron_morphology1.26009916
81MP0001800_abnormal_humoral_immune1.25141469
82MP0009333_abnormal_splenocyte_physiolog1.24833695
83MP0000371_diluted_coat_color1.24706900
84MP0000955_abnormal_spinal_cord1.24174361
85MP0005645_abnormal_hypothalamus_physiol1.23541853
86MP0001905_abnormal_dopamine_level1.23193581
87MP0003879_abnormal_hair_cell1.21352871
88MP0005423_abnormal_somatic_nervous1.17739073
89MP0001177_atelectasis1.17120925
90MP0003631_nervous_system_phenotype1.15726322
91MP0003075_altered_response_to1.14737819
92MP0003283_abnormal_digestive_organ1.14407344
93MP0002822_catalepsy1.12810609
94MP0002152_abnormal_brain_morphology1.11969732
95MP0004133_heterotaxia1.11521308
96MP0003635_abnormal_synaptic_transmissio1.10075438
97MP0002019_abnormal_tumor_incidence1.10017257
98MP0002075_abnormal_coat/hair_pigmentati1.10012492
99MP0010155_abnormal_intestine_physiology1.09397075
100MP0001485_abnormal_pinna_reflex1.08848293
101MP0004957_abnormal_blastocyst_morpholog1.08787002
102MP0001845_abnormal_inflammatory_respons1.07576385
103MP0004142_abnormal_muscle_tone1.05797615
104MP0001873_stomach_inflammation1.03452204
105MP0009780_abnormal_chondrocyte_physiolo1.03333952
106MP0002272_abnormal_nervous_system1.03150840
107MP0000703_abnormal_thymus_morphology1.02808115
108MP0003191_abnormal_cellular_cholesterol1.02513371
109MP0000537_abnormal_urethra_morphology1.01123156
110MP0006036_abnormal_mitochondrial_physio1.00703021
111MP0000358_abnormal_cell_content/1.00398085
112MP0003077_abnormal_cell_cycle1.00234390
113MP0003890_abnormal_embryonic-extraembry0.99895045
114MP0003938_abnormal_ear_development0.99653625
115MP0008469_abnormal_protein_level0.98538250
116MP0002909_abnormal_adrenal_gland0.97973893
117MP0005409_darkened_coat_color0.97538220
118MP0004885_abnormal_endolymph0.97216918
119MP0000920_abnormal_myelination0.97162634
120MP0002734_abnormal_mechanical_nocicepti0.96761721
121MP0002229_neurodegeneration0.96747966
122MP0008569_lethality_at_weaning0.96683521
123MP0002638_abnormal_pupillary_reflex0.95861647
124MP0002166_altered_tumor_susceptibility0.95393530
125MP0005167_abnormal_blood-brain_barrier0.95155399
126MP0001984_abnormal_olfaction0.94936012
127MP0003121_genomic_imprinting0.93814899
128MP0000681_abnormal_thyroid_gland0.93481692
129MP0003111_abnormal_nucleus_morphology0.93081397
130MP0001963_abnormal_hearing_physiology0.91440244
131MP0001533_abnormal_skeleton_physiology0.90510298
132MP0002405_respiratory_system_inflammati0.90307777
133MP0000858_altered_metastatic_potential0.89717958
134MP0003119_abnormal_digestive_system0.88835672
135MP0008057_abnormal_DNA_replication0.88594995
136MP0000631_abnormal_neuroendocrine_gland0.86645895
137MP0004742_abnormal_vestibular_system0.84832061
138MP0009046_muscle_twitch0.84809121
139MP0005220_abnormal_exocrine_pancreas0.84719126
140MP0003638_abnormal_response/metabolism_0.84530888
141MP0003632_abnormal_nervous_system0.84455752
142MP0001663_abnormal_digestive_system0.84159521
143MP0002693_abnormal_pancreas_physiology0.82846579
144MP0000313_abnormal_cell_death0.82171396
145MP0004270_analgesia0.81952673
146MP0008872_abnormal_physiological_respon0.81645734
147MP0000604_amyloidosis0.79173765
148MP0008874_decreased_physiological_sensi0.78147622
149MP0003634_abnormal_glial_cell0.78037568
150MP0001944_abnormal_pancreas_morphology0.77700298
151MP0006292_abnormal_olfactory_placode0.77391339
152MP0005551_abnormal_eye_electrophysiolog0.76317458
153MP0003123_paternal_imprinting0.75093996
154MP0002069_abnormal_eating/drinking_beha0.74733422
155MP0001346_abnormal_lacrimal_gland0.71793134
156MP0001270_distended_abdomen0.70569826
157MP0001186_pigmentation_phenotype0.69822362
158MP0009278_abnormal_bone_marrow0.69773399
159MP0003861_abnormal_nervous_system0.68728418
160MP0002752_abnormal_somatic_nervous0.67236545
161MP0001529_abnormal_vocalization0.67214180
162MP0005499_abnormal_olfactory_system0.65740369
163MP0005394_taste/olfaction_phenotype0.65740369
164MP0010769_abnormal_survival0.63505451
165MP0010768_mortality/aging0.60308497
166MP0010770_preweaning_lethality0.59765885
167MP0002082_postnatal_lethality0.59765885
168MP0004130_abnormal_muscle_cell0.59593004
169MP0009672_abnormal_birth_weight0.55143854
170MP0008004_abnormal_stomach_pH0.54685672
171MP0000579_abnormal_nail_morphology0.53739107
172MP0002873_normal_phenotype0.53608345
173MP0002169_no_abnormal_phenotype0.52520288
174MP0003956_abnormal_body_size0.51664844
175MP0000026_abnormal_inner_ear0.51517789
176MP0000462_abnormal_digestive_system0.51294397
177MP0001348_abnormal_lacrimal_gland0.48166934
178MP0005535_abnormal_body_temperature0.47845332
179MP0002083_premature_death0.46870459

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.76929854
2Focal motor seizures (HP:0011153)6.75445922
3Focal seizures (HP:0007359)5.75510541
4Thrombocytosis (HP:0001894)5.47001066
5Aplastic anemia (HP:0001915)5.28068912
6Febrile seizures (HP:0002373)5.26158060
7Elevated erythrocyte sedimentation rate (HP:0003565)4.77208990
8Epileptic encephalopathy (HP:0200134)4.76149119
9Abnormal number of erythroid precursors (HP:0012131)4.54719061
10Type I transferrin isoform profile (HP:0003642)4.52155269
11Abnormality of cells of the erythroid lineage (HP:0012130)4.46808005
12Supranuclear gaze palsy (HP:0000605)4.43803410
13Action tremor (HP:0002345)4.28559610
14Atonic seizures (HP:0010819)4.22357421
15Reduced antithrombin III activity (HP:0001976)4.20510380
16Generalized tonic-clonic seizures (HP:0002069)3.95083534
17Progressive cerebellar ataxia (HP:0002073)3.81295500
18Ankle clonus (HP:0011448)3.79206695
19Chronic otitis media (HP:0000389)3.68390824
20Papilledema (HP:0001085)3.62777689
21Abnormality of binocular vision (HP:0011514)3.59312628
22Diplopia (HP:0000651)3.59312628
23Neurofibrillary tangles (HP:0002185)3.59207090
24Myositis (HP:0100614)3.56652338
25Abnormal glycosylation (HP:0012345)3.53682491
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.53682491
27Abnormal protein N-linked glycosylation (HP:0012347)3.53682491
28Abnormal protein glycosylation (HP:0012346)3.53682491
29Absence seizures (HP:0002121)3.48743031
30Ocular albinism (HP:0001107)3.40546390
31Torticollis (HP:0000473)3.39818478
32Poikiloderma (HP:0001029)3.34985315
33Dialeptic seizures (HP:0011146)3.34983825
34Postural instability (HP:0002172)3.32085777
35Visual hallucinations (HP:0002367)3.23985743
36Spastic gait (HP:0002064)3.23484595
37Urinary bladder sphincter dysfunction (HP:0002839)3.22491736
38Reticulocytopenia (HP:0001896)3.21600951
39Cerebral hypomyelination (HP:0006808)3.06435174
40IgM deficiency (HP:0002850)3.05683542
41Abnormal eating behavior (HP:0100738)3.02183127
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.98276509
43Annular pancreas (HP:0001734)2.97897110
44Impaired smooth pursuit (HP:0007772)2.94281438
45Iris hypopigmentation (HP:0007730)2.93261259
46Obstructive sleep apnea (HP:0002870)2.93234489
47Spinal canal stenosis (HP:0003416)2.89948616
48Cerebral inclusion bodies (HP:0100314)2.88211423
49Dysmetria (HP:0001310)2.87061265
50Severe visual impairment (HP:0001141)2.84630599
51Panhypogammaglobulinemia (HP:0003139)2.84303630
52Abnormality of T cell physiology (HP:0011840)2.83691353
53Focal dystonia (HP:0004373)2.83656704
54Poor eye contact (HP:0000817)2.77545157
55Limb dystonia (HP:0002451)2.77195425
56Hypothermia (HP:0002045)2.76315016
57Recurrent abscess formation (HP:0002722)2.73944662
58Intention tremor (HP:0002080)2.72036050
59Truncal ataxia (HP:0002078)2.70790967
60Impaired vibration sensation in the lower limbs (HP:0002166)2.70281324
61Status epilepticus (HP:0002133)2.69045435
62Craniofacial dystonia (HP:0012179)2.65858169
63Hemiplegia (HP:0002301)2.63715979
64Tetraplegia (HP:0002445)2.63097636
65Thyroid-stimulating hormone excess (HP:0002925)2.59709886
66Acute lymphatic leukemia (HP:0006721)2.59327984
67Microretrognathia (HP:0000308)2.58054825
68Dysostosis multiplex (HP:0000943)2.57903409
69Insomnia (HP:0100785)2.57063158
70Thoracic kyphosis (HP:0002942)2.53385974
71Prolonged bleeding time (HP:0003010)2.53006587
72Abnormal social behavior (HP:0012433)2.51441546
73Impaired social interactions (HP:0000735)2.51441546
74Stereotypic behavior (HP:0000733)2.49413336
75Entropion (HP:0000621)2.48450016
76Urinary urgency (HP:0000012)2.47818081
77Epileptiform EEG discharges (HP:0011182)2.45524235
78Gaze-evoked nystagmus (HP:0000640)2.43571874
79Dysdiadochokinesis (HP:0002075)2.41691248
80Albinism (HP:0001022)2.39605741
81Progressive muscle weakness (HP:0003323)2.39536170
82Petechiae (HP:0000967)2.39306589
83Hyperacusis (HP:0010780)2.38400163
84Recurrent bacterial skin infections (HP:0005406)2.37836124
85Pulmonary fibrosis (HP:0002206)2.36580360
86Abnormality of the prostate (HP:0008775)2.36237501
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34903452
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34903452
89Amblyopia (HP:0000646)2.32052631
90Pallor (HP:0000980)2.31632539
91Abnormality of ocular smooth pursuit (HP:0000617)2.31404365
92Gastrointestinal inflammation (HP:0004386)2.30434140
93Chest pain (HP:0100749)2.30004366
94Bradykinesia (HP:0002067)2.29536379
95Vacuolated lymphocytes (HP:0001922)2.29392810
96Choreoathetosis (HP:0001266)2.29313519
97Clonus (HP:0002169)2.29236196
98Spastic tetraparesis (HP:0001285)2.25770942
99Depression (HP:0000716)2.24552014
100Loss of speech (HP:0002371)2.24157244
101Epistaxis (HP:0000421)2.23338617
102Macrocytic anemia (HP:0001972)2.22811605
103Abnormality of the lower motor neuron (HP:0002366)2.22682909
104Hemiparesis (HP:0001269)2.22660737
105Generalized hypopigmentation (HP:0007513)2.22460259
106Inflammation of the large intestine (HP:0002037)2.21989707
107Neuronal loss in central nervous system (HP:0002529)2.20977599
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19003524
109Anxiety (HP:0000739)2.17328458
110Hypomagnesemia (HP:0002917)2.16496431
111Sleep apnea (HP:0010535)2.16087330
112Meningitis (HP:0001287)2.14764836
113Chronic obstructive pulmonary disease (HP:0006510)2.14587458
114Obstructive lung disease (HP:0006536)2.14587458
115Abnormality of the nasal mucosa (HP:0000433)2.12640563
116Scanning speech (HP:0002168)2.12531120
117EEG with generalized epileptiform discharges (HP:0011198)2.12115276
118Nasal polyposis (HP:0100582)2.11873360
119Hepatocellular necrosis (HP:0001404)2.11792438
120Bronchomalacia (HP:0002780)2.10483947
121Erythema (HP:0010783)2.10303390
122Interstitial pulmonary disease (HP:0006530)2.08762793
123Abnormality of the columella (HP:0009929)2.08666295
124Overriding aorta (HP:0002623)2.08414580
125Lower limb muscle weakness (HP:0007340)2.08285991
126Abnormality of DNA repair (HP:0003254)2.07311854
127Broad face (HP:0000283)2.06633913
128Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06140185
129Thickened helices (HP:0000391)2.05303460
130Abnormality of macrophages (HP:0004311)2.04616728
131Abnormality of the thoracic spine (HP:0100711)2.04587649
132Progressive neurologic deterioration (HP:0002344)2.03773624
133Hepatic necrosis (HP:0002605)2.03712986
134Urinary glycosaminoglycan excretion (HP:0003541)2.03695737
135Mucopolysacchariduria (HP:0008155)2.03695737
136Hypsarrhythmia (HP:0002521)2.03470884
137Lower limb asymmetry (HP:0100559)2.02839081
138Impaired platelet aggregation (HP:0003540)2.01313573
139Abnormal platelet function (HP:0011869)2.01313573
140Late onset (HP:0003584)2.00489012
141Dysmetric saccades (HP:0000641)1.99560054
142Broad-based gait (HP:0002136)1.96581870
143Drooling (HP:0002307)1.95012085
144Split foot (HP:0001839)1.94442533
145B lymphocytopenia (HP:0010976)1.94038548
146Abnormality of B cell number (HP:0010975)1.94038548
147Delusions (HP:0000746)1.93249764
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92037953
149Abnormality of polysaccharide metabolism (HP:0011012)1.92037953
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92037953
151Abnormality of the corticospinal tract (HP:0002492)1.91795792
152Pancytopenia (HP:0001876)1.91406858
153Recurrent bronchitis (HP:0002837)1.88776499
154Cortical visual impairment (HP:0100704)1.88038681
155Apathy (HP:0000741)1.87531535
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87476801
157CNS hypomyelination (HP:0003429)1.87373654
158Joint stiffness (HP:0001387)1.86371833
159Abnormality of the labia minora (HP:0012880)1.86108075
160Unsteady gait (HP:0002317)1.85762652
161Recurrent skin infections (HP:0001581)1.85504752
162Morphological abnormality of the pyramidal tract (HP:0002062)1.85088702
163Abnormality of magnesium homeostasis (HP:0004921)1.84933370
164Impaired vibratory sensation (HP:0002495)1.84679129
165Hepatoblastoma (HP:0002884)1.84258817
166Hypergammaglobulinemia (HP:0010702)1.80900547
167Increased intramyocellular lipid droplets (HP:0012240)1.80410841
168Incomplete penetrance (HP:0003829)1.80396210
169Pointed chin (HP:0000307)1.80156555
170Exertional dyspnea (HP:0002875)1.79988469
171Type II lissencephaly (HP:0007260)1.79961752
172Abnormality of liposaccharide metabolism (HP:0010968)1.79115212
173Abnormality of glycosphingolipid metabolism (HP:0004343)1.79115212
174Abnormality of glycolipid metabolism (HP:0010969)1.79115212
175Oral leukoplakia (HP:0002745)1.79001371
176Colitis (HP:0002583)1.77359859
177Myelodysplasia (HP:0002863)1.77221058
178Recurrent viral infections (HP:0004429)1.76274356
179Excessive salivation (HP:0003781)1.75627752
180Abnormality of saccadic eye movements (HP:0000570)1.74733496
181Agnosia (HP:0010524)1.74159656
182Lymphoma (HP:0002665)1.73320865
183Septo-optic dysplasia (HP:0100842)1.72630487
184Mutism (HP:0002300)1.72133457
185Neurodegeneration (HP:0002180)1.71245590
186Rigidity (HP:0002063)1.70833726
187Diminished motivation (HP:0000745)1.70416643
188Deeply set eye (HP:0000490)1.69713712
189Renovascular hypertension (HP:0100817)1.69424878
190Akinesia (HP:0002304)1.68951037
191Spastic tetraplegia (HP:0002510)1.66741855
192Ventricular fibrillation (HP:0001663)1.66528754
193Genetic anticipation (HP:0003743)1.64997167
194Protruding tongue (HP:0010808)1.64476798
195Sporadic (HP:0003745)1.64209599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.46438537
2TNIK4.70368529
3PAK63.72383818
4DAPK23.63185366
5EIF2AK33.42049775
6EEF2K3.15145926
7CAMKK23.10082083
8STK163.09144533
9FLT33.08425284
10SCYL22.82588752
11MARK12.80865353
12CDK192.77708879
13KIT2.70851738
14NTRK22.56134760
15MAP2K32.42239904
16RIPK42.38343394
17FES2.27751955
18MAPKAPK32.25498443
19PRKD32.10575575
20MAP3K62.08542206
21MAP3K121.97157633
22PIM21.96858182
23TEC1.83096966
24PLK21.79520096
25TYRO31.71361011
26WEE11.61569804
27CCNB11.57254455
28CDK51.54856531
29MAP3K101.51686048
30CSF1R1.51129942
31MAP4K11.46692270
32DAPK11.46189416
33BTK1.40392223
34RPS6KB21.40043378
35CASK1.38251141
36LATS21.35286757
37MAPKAPK51.33654994
38CAMKK11.32947320
39MAPK151.32031592
40GRK51.31604718
41OXSR11.27718901
42RIPK11.24027495
43IRAK41.23883066
44MATK1.23756479
45ZAP701.23539485
46PHKG21.21720457
47PHKG11.21720457
48PRKCH1.20558106
49VRK11.20047509
50MAP2K71.18826910
51SGK2231.18349822
52SGK4941.18349822
53RAF11.17887627
54PRPF4B1.15255754
55PRKCG1.15014319
56CDK151.12149914
57PINK11.12123846
58STK111.11415923
59BRAF1.11136720
60ACVR1B1.10285905
61CDK181.08858036
62NLK1.08238778
63TBK11.06443767
64ALK1.05205844
65PKN21.03553732
66CDK11A1.03489809
67CAMK11.03235670
68CAMK2B1.02479048
69SYK1.02147533
70FGFR20.98348373
71ADRBK20.98259525
72MAPK120.97067646
73BUB10.96819411
74TAOK30.96703385
75DYRK1A0.93111743
76PIK3CG0.90213709
77NEK60.90117470
78MAP3K110.90092827
79CDK140.89556312
80ERN10.85803872
81PAK40.85502642
82NTRK30.84565363
83PKN10.84230206
84MAP3K90.81935956
85CAMK2A0.80159004
86TGFBR20.79953392
87DAPK30.79656390
88BLK0.79586804
89MAP3K10.79237273
90SGK20.77862088
91NME20.77552193
92DYRK30.76859364
93BRSK20.75902050
94CAMK1D0.75681439
95CAMK1G0.74798077
96ARAF0.73966527
97SGK10.73587152
98MAPK100.72904599
99MINK10.70325529
100BCKDK0.70273001
101CDK120.69921378
102TGFBR10.68909525
103STK390.67249477
104LMTK20.66727662
105LRRK20.64999873
106BRSK10.64591123
107MAP2K60.64109331
108MAPK40.63504856
109PRKG20.62919647
110EIF2AK10.61731365
111LYN0.60460171
112EIF2AK20.60336963
113CAMK2G0.60253085
114JAK30.60133110
115TAOK10.59916443
116HIPK20.59386707
117RPS6KA30.59048361
118YES10.58744120
119MAPK130.58622044
120CDK80.56307655
121TESK20.56233341
122KDR0.55766355
123PDPK10.55239230
124PASK0.54835059
125UHMK10.54455776
126TRIB30.54324742
127CAMK40.51788826
128SGK30.50650530
129PAK30.49610256
130MUSK0.49250078
131RPS6KA40.49246449
132PRKCZ0.48695352
133LIMK10.47791587
134ATR0.45512792
135BRD40.45461115
136LCK0.44910459
137ILK0.44162222
138AKT20.43630190
139ITK0.42144197
140CSNK1D0.40708950
141PRKDC0.40393224
142MAP2K40.40124070
143MARK20.38882837
144CDK70.37716717
145GSK3B0.37068511
146RPS6KA20.36833244
147PRKCA0.33009548
148FYN0.32660391
149TNK20.31405436
150TIE10.31169212
151SMG10.31083351
152PRKD20.30378015
153NTRK10.29924784
154CSNK1A10.29311984
155TRPM70.28924390
156MAPK80.28839059
157TLK10.28396895
158MAPK110.28317289
159NEK20.28153497
160CSNK1E0.27121871
161PDK10.26975365
162CDC70.26558735
163KSR20.26479986
164ERBB20.26268811
165RET0.25747050
166PRKCB0.25733552
167MAP3K40.25573184
168MAP3K130.25544851
169IKBKB0.25275784
170SIK20.24541743
171HCK0.23659558

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.93030685
2Ribosome_Homo sapiens_hsa030104.00448308
3Mismatch repair_Homo sapiens_hsa034303.17476986
4GABAergic synapse_Homo sapiens_hsa047272.91184053
5Morphine addiction_Homo sapiens_hsa050322.77307989
6N-Glycan biosynthesis_Homo sapiens_hsa005102.60154483
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.35694886
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34790483
9Base excision repair_Homo sapiens_hsa034102.29248859
10Gastric acid secretion_Homo sapiens_hsa049712.27430905
11Homologous recombination_Homo sapiens_hsa034402.13431159
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12291607
13Other glycan degradation_Homo sapiens_hsa005112.06212959
14Vitamin B6 metabolism_Homo sapiens_hsa007501.99882884
15Taste transduction_Homo sapiens_hsa047421.92846300
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.89005477
17Salivary secretion_Homo sapiens_hsa049701.86571110
18Cocaine addiction_Homo sapiens_hsa050301.83783689
19Nucleotide excision repair_Homo sapiens_hsa034201.79016358
20Protein export_Homo sapiens_hsa030601.77909829
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74786937
22Pyrimidine metabolism_Homo sapiens_hsa002401.67501067
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63944142
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59178925
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.57430966
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54395386
27Oxytocin signaling pathway_Homo sapiens_hsa049211.51620313
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50384050
29cAMP signaling pathway_Homo sapiens_hsa040241.49406269
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46476655
31Proteasome_Homo sapiens_hsa030501.45304810
32Pentose phosphate pathway_Homo sapiens_hsa000301.39925681
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39834393
34Spliceosome_Homo sapiens_hsa030401.34148865
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33316453
36Serotonergic synapse_Homo sapiens_hsa047261.30410182
37Thyroid cancer_Homo sapiens_hsa052161.27373381
38Leishmaniasis_Homo sapiens_hsa051401.27362328
39Renin-angiotensin system_Homo sapiens_hsa046141.26457596
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26354680
41Acute myeloid leukemia_Homo sapiens_hsa052211.23349037
42Olfactory transduction_Homo sapiens_hsa047401.22713915
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20406692
44Antigen processing and presentation_Homo sapiens_hsa046121.16295615
45Shigellosis_Homo sapiens_hsa051311.16009723
46Melanogenesis_Homo sapiens_hsa049161.14556442
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11590615
48Glioma_Homo sapiens_hsa052141.10468093
49B cell receptor signaling pathway_Homo sapiens_hsa046621.10343321
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09596221
51Primary immunodeficiency_Homo sapiens_hsa053401.09311513
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08149583
53Cardiac muscle contraction_Homo sapiens_hsa042601.07614383
54Oocyte meiosis_Homo sapiens_hsa041141.07500356
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06764642
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06139707
57Folate biosynthesis_Homo sapiens_hsa007901.03449391
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03193320
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01592002
60Pertussis_Homo sapiens_hsa051331.01280509
61Thyroid hormone synthesis_Homo sapiens_hsa049181.01271082
62Pancreatic secretion_Homo sapiens_hsa049721.00929779
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.98860223
64Renin secretion_Homo sapiens_hsa049240.96725435
65Galactose metabolism_Homo sapiens_hsa000520.95638393
66RNA polymerase_Homo sapiens_hsa030200.94833409
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93443182
68Estrogen signaling pathway_Homo sapiens_hsa049150.91592015
69Type II diabetes mellitus_Homo sapiens_hsa049300.90063335
70ErbB signaling pathway_Homo sapiens_hsa040120.89457558
71Osteoclast differentiation_Homo sapiens_hsa043800.87668771
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87435330
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87404173
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87257685
75Gap junction_Homo sapiens_hsa045400.86822570
76Circadian entrainment_Homo sapiens_hsa047130.85616216
77Phototransduction_Homo sapiens_hsa047440.84983015
78Long-term potentiation_Homo sapiens_hsa047200.84394918
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84194522
80Lysosome_Homo sapiens_hsa041420.83830538
81Fanconi anemia pathway_Homo sapiens_hsa034600.82825678
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.82480567
83Cell cycle_Homo sapiens_hsa041100.81119479
84Salmonella infection_Homo sapiens_hsa051320.79878671
85Herpes simplex infection_Homo sapiens_hsa051680.79533436
86Purine metabolism_Homo sapiens_hsa002300.78858501
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.78368533
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78182167
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77744301
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77529488
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76473451
92Sulfur relay system_Homo sapiens_hsa041220.75789836
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73971642
94Platelet activation_Homo sapiens_hsa046110.72427198
95Wnt signaling pathway_Homo sapiens_hsa043100.72053601
96Glucagon signaling pathway_Homo sapiens_hsa049220.71812632
97Inositol phosphate metabolism_Homo sapiens_hsa005620.71620597
98Non-homologous end-joining_Homo sapiens_hsa034500.71397648
99Bile secretion_Homo sapiens_hsa049760.68319083
100RNA degradation_Homo sapiens_hsa030180.67112122
101Ras signaling pathway_Homo sapiens_hsa040140.66857300
102Legionellosis_Homo sapiens_hsa051340.64931597
103beta-Alanine metabolism_Homo sapiens_hsa004100.64758932
104MAPK signaling pathway_Homo sapiens_hsa040100.62190376
105Tuberculosis_Homo sapiens_hsa051520.60219196
106Rap1 signaling pathway_Homo sapiens_hsa040150.59260141
107Glutamatergic synapse_Homo sapiens_hsa047240.58947370
108p53 signaling pathway_Homo sapiens_hsa041150.58896401
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58199373
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58098387
111Alcoholism_Homo sapiens_hsa050340.57960888
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.57385244
113Insulin secretion_Homo sapiens_hsa049110.56703882
114Collecting duct acid secretion_Homo sapiens_hsa049660.55663703
115Selenocompound metabolism_Homo sapiens_hsa004500.55411060
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54834092
117Hepatitis B_Homo sapiens_hsa051610.54694184
118RNA transport_Homo sapiens_hsa030130.54134586
119Measles_Homo sapiens_hsa051620.54093175
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52264942
121Synaptic vesicle cycle_Homo sapiens_hsa047210.52011911
122Axon guidance_Homo sapiens_hsa043600.50494177
123Systemic lupus erythematosus_Homo sapiens_hsa053220.50333384
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48697764
125Tight junction_Homo sapiens_hsa045300.47406753
126Long-term depression_Homo sapiens_hsa047300.46295077
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45841041
128GnRH signaling pathway_Homo sapiens_hsa049120.45790010
129Influenza A_Homo sapiens_hsa051640.44747722
130Hematopoietic cell lineage_Homo sapiens_hsa046400.44356753
131Amphetamine addiction_Homo sapiens_hsa050310.43815872
132Dopaminergic synapse_Homo sapiens_hsa047280.43295220
133VEGF signaling pathway_Homo sapiens_hsa043700.43279295
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.43056628
135Apoptosis_Homo sapiens_hsa042100.42824924
136Ovarian steroidogenesis_Homo sapiens_hsa049130.42784983
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42654639
138Regulation of autophagy_Homo sapiens_hsa041400.42277450
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41724397
140Epstein-Barr virus infection_Homo sapiens_hsa051690.41452088
141Colorectal cancer_Homo sapiens_hsa052100.41194871
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.41126906
143Vibrio cholerae infection_Homo sapiens_hsa051100.40105215
144Fructose and mannose metabolism_Homo sapiens_hsa000510.40053186
145Cholinergic synapse_Homo sapiens_hsa047250.39324825
146Calcium signaling pathway_Homo sapiens_hsa040200.38779559
147Nicotine addiction_Homo sapiens_hsa050330.38363483
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.37322894
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37139490
150Fatty acid biosynthesis_Homo sapiens_hsa000610.36483488
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36165771
152Arginine biosynthesis_Homo sapiens_hsa002200.35867952
153Insulin signaling pathway_Homo sapiens_hsa049100.35500357
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34763916
155Hippo signaling pathway_Homo sapiens_hsa043900.34469601
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.30490991
157Choline metabolism in cancer_Homo sapiens_hsa052310.30209357
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29889141
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29841181
160Arginine and proline metabolism_Homo sapiens_hsa003300.29717106
161Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29117800
162Mineral absorption_Homo sapiens_hsa049780.28938378
163HIF-1 signaling pathway_Homo sapiens_hsa040660.24497536
164Alzheimers disease_Homo sapiens_hsa050100.23719342
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21677759
166mRNA surveillance pathway_Homo sapiens_hsa030150.18936499
167Basal cell carcinoma_Homo sapiens_hsa052170.18559444
168Endocytosis_Homo sapiens_hsa041440.17336639
169AMPK signaling pathway_Homo sapiens_hsa041520.16987055
170Dilated cardiomyopathy_Homo sapiens_hsa054140.15032220
171Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13469288
172Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13416575
173Melanoma_Homo sapiens_hsa052180.11167296

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