KCNK13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.98364737
2central nervous system myelination (GO:0022010)9.98364737
3fatty acid elongation (GO:0030497)5.83873890
4myelin maintenance (GO:0043217)5.44111731
5long-chain fatty acid biosynthetic process (GO:0042759)5.43257811
6ensheathment of neurons (GO:0007272)5.40088780
7axon ensheathment (GO:0008366)5.40088780
8myelination (GO:0042552)5.32455184
9negative regulation of interleukin-12 production (GO:0032695)5.24591623
10response to peptidoglycan (GO:0032494)5.22979065
11response to methylmercury (GO:0051597)5.12009658
12L-amino acid import (GO:0043092)5.02846746
13glycosphingolipid catabolic process (GO:0046479)4.88310209
14response to lipoprotein particle (GO:0055094)4.57741390
15amyloid precursor protein metabolic process (GO:0042982)4.45760555
16glycolipid catabolic process (GO:0019377)4.37422585
17oligosaccharide catabolic process (GO:0009313)4.33668449
18neutrophil activation involved in immune response (GO:0002283)4.29574636
19import into cell (GO:0098657)4.23134165
20cellular response to thyroid hormone stimulus (GO:0097067)4.22289408
21regulation of mononuclear cell migration (GO:0071675)4.12819784
22leukocyte migration involved in inflammatory response (GO:0002523)4.10546037
23negative regulation of neurotransmitter secretion (GO:0046929)4.08768863
24immunoglobulin mediated immune response (GO:0016064)4.07420055
25negative regulation of neurotransmitter transport (GO:0051589)4.04693014
26T-helper 1 type immune response (GO:0042088)4.00483381
27positive regulation of gamma-delta T cell activation (GO:0046645)4.00331254
28amyloid precursor protein catabolic process (GO:0042987)3.95438161
29glycosylceramide metabolic process (GO:0006677)3.94984000
30negative regulation of protein localization to cell surface (GO:2000009)3.87299723
31glycerophospholipid catabolic process (GO:0046475)3.85372922
32regulation of collateral sprouting (GO:0048670)3.84146071
33ceramide catabolic process (GO:0046514)3.83937755
34positive regulation of mast cell activation (GO:0033005)3.82797291
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.82018099
36amino sugar catabolic process (GO:0046348)3.75380412
37positive regulation of mast cell degranulation (GO:0043306)3.74449131
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.74449131
39creatine metabolic process (GO:0006600)3.70450571
40amino acid import (GO:0043090)3.63952532
41regulation of mast cell degranulation (GO:0043304)3.63499826
42positive regulation of leukocyte degranulation (GO:0043302)3.63210783
43positive regulation of monocyte chemotaxis (GO:0090026)3.62968757
44positive regulation by symbiont of host defense response (GO:0052509)3.59779067
45modulation by symbiont of host defense response (GO:0052031)3.59779067
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59779067
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59779067
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.59779067
49modulation by symbiont of host immune response (GO:0052553)3.59779067
50detection of molecule of bacterial origin (GO:0032490)3.54472414
51regulation of vitamin D biosynthetic process (GO:0060556)3.51227474
52positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.48937301
53oligodendrocyte differentiation (GO:0048709)3.48881758
54regulation of lipoprotein metabolic process (GO:0050746)3.45591666
55negative regulation of macroautophagy (GO:0016242)3.45117197
56regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.44255308
57establishment of mitochondrion localization (GO:0051654)3.43984060
58cellular extravasation (GO:0045123)3.43811762
59myeloid dendritic cell differentiation (GO:0043011)3.43738585
60regulation of cholesterol storage (GO:0010885)3.42343399
61positive regulation of oligodendrocyte differentiation (GO:0048714)3.42225929
62positive regulation of antigen processing and presentation (GO:0002579)3.38734237
63N-acetylneuraminate metabolic process (GO:0006054)3.38464208
64positive regulation of cellular amide metabolic process (GO:0034250)3.37813924
65cholesterol biosynthetic process (GO:0006695)3.37792316
66NIK/NF-kappaB signaling (GO:0038061)3.37495609
67regulation of leukocyte degranulation (GO:0043300)3.35834279
68regulation of mast cell activation involved in immune response (GO:0033006)3.32342502
69macrophage activation involved in immune response (GO:0002281)3.31852161
70response to muramyl dipeptide (GO:0032495)3.30951262
71positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.30356977
72response to thyroid hormone (GO:0097066)3.30203515
73regulation of myeloid leukocyte mediated immunity (GO:0002886)3.28983008
74membrane lipid catabolic process (GO:0046466)3.27229080
75protein localization to endosome (GO:0036010)3.25871822
76microglial cell activation (GO:0001774)3.24696962
77detection of other organism (GO:0098543)3.23191223
78interferon-gamma-mediated signaling pathway (GO:0060333)3.18389929
79regulation of interferon-alpha production (GO:0032647)3.17483672
80adult walking behavior (GO:0007628)3.17451919
81myeloid dendritic cell activation (GO:0001773)3.17311685
82regulation of mast cell activation (GO:0033003)3.16497444
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.12524702
84negative regulation of cell killing (GO:0031342)3.11324891
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11324891
86membrane raft organization (GO:0031579)3.11165686
87monocyte chemotaxis (GO:0002548)3.11099995
88macrophage differentiation (GO:0030225)3.10991155
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09003283
90regulation of podosome assembly (GO:0071801)3.08588351
91sphingolipid catabolic process (GO:0030149)3.08395736
92regulation of antigen processing and presentation (GO:0002577)3.08286649
93germinal center formation (GO:0002467)3.07200004
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07106494
95regulation of macrophage chemotaxis (GO:0010758)3.06743196
96sterol biosynthetic process (GO:0016126)3.06357393
97positive regulation of chemokine biosynthetic process (GO:0045080)3.05972533
98detection of external biotic stimulus (GO:0098581)3.05927169
99long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97837587
100B cell mediated immunity (GO:0019724)2.97707104
101positive regulation of type 2 immune response (GO:0002830)2.95122129
102peptidyl-tyrosine autophosphorylation (GO:0038083)2.92945364
103dendritic cell differentiation (GO:0097028)2.92033410
104positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91692135
105barbed-end actin filament capping (GO:0051016)2.89979539
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89429337
107regulation of monocyte chemotaxis (GO:0090025)2.89293363
108mannose metabolic process (GO:0006013)2.89180838
109membrane tubulation (GO:0097320)2.87862192
110regulation of cytokine secretion involved in immune response (GO:0002739)2.87391509
111negative regulation of cytokine production involved in immune response (GO:0002719)2.86040350
112regulation of T-helper 1 cell differentiation (GO:0045625)2.85292389
113negative regulation of erythrocyte differentiation (GO:0045647)2.85053551
114detection of bacterium (GO:0016045)2.84591958
115negative regulation of nitric oxide biosynthetic process (GO:0045019)2.83835958
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.83774186
117positive regulation of interferon-alpha production (GO:0032727)2.83186815
118nerve growth factor signaling pathway (GO:0038180)2.82179181
119regulation of T-helper 2 cell differentiation (GO:0045628)2.82122166
120adhesion of symbiont to host (GO:0044406)2.81302411
121regulation of interleukin-12 production (GO:0032655)2.80230830
122regulation of hypersensitivity (GO:0002883)2.79986972
123pinocytosis (GO:0006907)2.79933361
124magnesium ion transport (GO:0015693)2.79101395
125neutrophil activation (GO:0042119)2.78892065
126response to protozoan (GO:0001562)2.78802007
127negative regulation of myeloid cell apoptotic process (GO:0033033)2.78327106
128isoprenoid biosynthetic process (GO:0008299)2.77720440
129cellular response to lipopolysaccharide (GO:0071222)2.76604583
130detection of biotic stimulus (GO:0009595)2.76148426
131regulation of T cell tolerance induction (GO:0002664)2.75824741
132myeloid cell activation involved in immune response (GO:0002275)2.75286063
133long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.75097488
134negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.74371654
135respiratory burst (GO:0045730)2.73930735
136negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.72303341
137detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.71659613
138detection of temperature stimulus involved in sensory perception (GO:0050961)2.71659613
139photoreceptor cell differentiation (GO:0046530)2.70489092
140eye photoreceptor cell differentiation (GO:0001754)2.70489092
141glycine transport (GO:0015816)2.69394860
142asymmetric protein localization (GO:0008105)2.69161314
143tissue regeneration (GO:0042246)2.68912017
144axon development (GO:0061564)2.64042698
145astrocyte development (GO:0014002)2.59617646
146protein palmitoylation (GO:0018345)2.57996053
147cortical actin cytoskeleton organization (GO:0030866)2.57511723
148regulation of interferon-beta biosynthetic process (GO:0045357)2.54876731
149regulation of T cell migration (GO:2000404)2.53591040
150positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.52767017
151GPI anchor biosynthetic process (GO:0006506)2.51865470
152response to redox state (GO:0051775)2.51592274
153neuron remodeling (GO:0016322)2.50321955
154neurotransmitter uptake (GO:0001504)2.45772640
155fatty-acyl-CoA biosynthetic process (GO:0046949)2.44344856
156presynaptic membrane organization (GO:0097090)2.41137387
157virion attachment to host cell (GO:0019062)2.40856861
158adhesion of symbiont to host cell (GO:0044650)2.40856861
159adenosine receptor signaling pathway (GO:0001973)2.40076255
160GPI anchor metabolic process (GO:0006505)2.39302950
161cortical cytoskeleton organization (GO:0030865)2.39192574
162positive regulation of gliogenesis (GO:0014015)2.39105294
163fatty-acyl-CoA metabolic process (GO:0035337)2.37640392
164response to nerve growth factor (GO:1990089)2.37558680
165cellular response to nerve growth factor stimulus (GO:1990090)2.37558680
166very long-chain fatty acid metabolic process (GO:0000038)2.37502522
167substantia nigra development (GO:0021762)2.35972560
168apical protein localization (GO:0045176)2.35324796
169macrophage activation (GO:0042116)2.34967744
170positive regulation of chemokine secretion (GO:0090197)2.33447325
171positive regulation of toll-like receptor signaling pathway (GO:0034123)2.32167143
172negative regulation of acute inflammatory response (GO:0002674)2.31766004
173regulation of lymphocyte migration (GO:2000401)2.31305285
174neuronal action potential propagation (GO:0019227)2.30183244
175enteric nervous system development (GO:0048484)2.29955890
176intracellular pH reduction (GO:0051452)2.29670252
177regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.28899743
178negative regulation of execution phase of apoptosis (GO:1900118)2.28628600
179regulation of amyloid precursor protein catabolic process (GO:1902991)2.26633601
180Golgi to endosome transport (GO:0006895)2.26047699
181negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.23065406
182positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.22964625
183regulation of macroautophagy (GO:0016241)2.22849228
184granulocyte activation (GO:0036230)2.22118878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.56478027
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.18306356
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.99735992
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.79473265
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.63782049
6VDR_21846776_ChIP-Seq_THP-1_Human2.48917821
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.48418158
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42967634
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42149075
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.38175496
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35801439
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35689765
13BRD4_27068464_Chip-Seq_AML-cells_Mouse2.32344516
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30865552
15SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.28857992
16SPI1_23547873_ChIP-Seq_NB4_Human2.24747576
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20387524
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19245080
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17462804
20GBX2_23144817_ChIP-Seq_PC3_Human2.10472080
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.09607263
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01211315
23SCL_19346495_ChIP-Seq_HPC-7_Human1.89462411
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.82878348
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78104251
26LXR_22292898_ChIP-Seq_THP-1_Human1.75400855
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.74116252
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73919992
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73498058
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.72564712
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70591175
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69625421
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68672285
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64789438
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60370607
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59991084
37* PU_27001747_Chip-Seq_BMDM_Mouse1.57784349
38* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55912215
39GATA1_22025678_ChIP-Seq_K562_Human1.55025600
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53115913
41VDR_24787735_ChIP-Seq_THP-1_Human1.51085219
42MAF_26560356_Chip-Seq_TH1_Human1.50863666
43* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50815095
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50015415
45* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49487779
46AR_21572438_ChIP-Seq_LNCaP_Human1.48911394
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48747199
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.47101594
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44270186
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44036133
51MYC_22102868_ChIP-Seq_BL_Human1.43781960
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40547794
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.39911877
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39587982
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38796744
56TFEB_21752829_ChIP-Seq_HELA_Human1.37199953
57TCF7_22412390_ChIP-Seq_EML_Mouse1.37039439
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35242626
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35242626
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35223923
61VDR_22108803_ChIP-Seq_LS180_Human1.35154880
62ER_23166858_ChIP-Seq_MCF-7_Human1.33472158
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33045229
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32590690
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30902617
66* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30419052
67MYB_26560356_Chip-Seq_TH2_Human1.29798389
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29328179
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28559209
70KDM2B_26808549_Chip-Seq_DND41_Human1.28089606
71* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27635485
72* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27635485
73DROSHA_22980978_ChIP-Seq_HELA_Human1.26588990
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26155970
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.25975100
76EZH2_22144423_ChIP-Seq_EOC_Human1.25927186
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25850830
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25506752
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25333503
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24313407
81* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24176567
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23225850
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23141363
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21953528
85UTX_26944678_Chip-Seq_JUKART_Human1.19462651
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19425601
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18908975
88* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17729259
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17607918
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17523771
91* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17379089
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17235530
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17103249
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16619410
95SPI1_23127762_ChIP-Seq_K562_Human1.16241673
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15798606
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15156643
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12415808
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12047449
100TAF15_26573619_Chip-Seq_HEK293_Human1.11897887
101RUNX_20019798_ChIP-Seq_JUKART_Human1.10571057
102LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10051784
103* EZH2_27294783_Chip-Seq_ESCs_Mouse1.08816398
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08019140
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07779683
106MAF_26560356_Chip-Seq_TH2_Human1.07385666
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06791663
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.06411532
109* RNF2_27304074_Chip-Seq_ESCs_Mouse1.05409648
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.04439694
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03342008
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02758861
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.02721928
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02333660
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01298910
116MYB_26560356_Chip-Seq_TH1_Human1.00984251
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00871246
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00793649
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00479347
120GATA1_19941826_ChIP-Seq_K562_Human1.00412853
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.00345301
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00148205
123IGF1R_20145208_ChIP-Seq_DFB_Human0.99677794
124* KDM2B_26808549_Chip-Seq_K562_Human0.96619751
125EGR1_19032775_ChIP-ChIP_M12_Human0.95332618
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95331712
127RARB_27405468_Chip-Seq_BRAIN_Mouse0.95297190
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95243719
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.95032949
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93908117
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93760355
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93683899
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93636693
134AHR_22903824_ChIP-Seq_MCF-7_Human0.93460284
135STAT1_20625510_ChIP-Seq_HELA_Human0.93252869
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93252857
137GATA3_27048872_Chip-Seq_THYMUS_Human0.92982050
138EOMES_21245162_ChIP-Seq_HESCs_Human0.92736931
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91794536
140IRF8_22096565_ChIP-ChIP_GC-B_Human0.90111191
141* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89319243
142BCL6_27268052_Chip-Seq_Bcells_Human0.88963587
143RXR_22158963_ChIP-Seq_LIVER_Mouse0.87701822
144RACK7_27058665_Chip-Seq_MCF-7_Human0.87022758
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.86867865
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.86828497
147PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86762884
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86598276
149BCOR_27268052_Chip-Seq_Bcells_Human0.86085184
150* EED_16625203_ChIP-ChIP_MESCs_Mouse0.85482947
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85478287
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84882753
153TP53_16413492_ChIP-PET_HCT116_Human0.84771423
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84617537
155* EZH2_27304074_Chip-Seq_ESCs_Mouse0.84478019
156TAL1_26923725_Chip-Seq_HPCs_Mouse0.84447743
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.83923780
158MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82584294
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81803712
160LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81784868
161STAT3_23295773_ChIP-Seq_U87_Human0.81728227
162P300_19829295_ChIP-Seq_ESCs_Human0.81034668
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80670580
164SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80186452
165CJUN_26792858_Chip-Seq_BT549_Human0.80095797
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.80028393
167* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79690376
168TP63_23658742_ChIP-Seq_EP156T_Human0.79291600
169NANOG_19829295_ChIP-Seq_ESCs_Human0.78831645
170SOX2_19829295_ChIP-Seq_ESCs_Human0.78831645
171ELF1_20517297_ChIP-Seq_JURKAT_Human0.78057180
172VDR_24763502_ChIP-Seq_THP-1_Human0.77916087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.28658398
2MP0005058_abnormal_lysosome_morphology4.62467941
3MP0003690_abnormal_glial_cell4.21788410
4MP0003950_abnormal_plasma_membrane3.57579994
5MP0009840_abnormal_foam_cell3.04960023
6MP0000604_amyloidosis2.95491457
7MP0003172_abnormal_lysosome_physiology2.91275471
8MP0006082_CNS_inflammation2.81630637
9MP0003329_amyloid_beta_deposits2.79602602
10MP0009785_altered_susceptibility_to2.69780129
11MP0003634_abnormal_glial_cell2.48320039
12MP0004270_analgesia2.43858062
13MP0002139_abnormal_hepatobiliary_system2.34012313
14MP0008260_abnormal_autophagy2.26247987
15MP0003880_abnormal_central_pattern2.23496773
16MP0005171_absent_coat_pigmentation2.21743800
17MP0000685_abnormal_immune_system2.09152634
18MP0005451_abnormal_body_composition2.08688001
19MP0003303_peritoneal_inflammation2.04709759
20MP0009278_abnormal_bone_marrow1.96027958
21MP0001529_abnormal_vocalization1.87635243
22MP0002419_abnormal_innate_immunity1.86642767
23MP0003632_abnormal_nervous_system1.84142434
24MP0004885_abnormal_endolymph1.83896573
25MP0001905_abnormal_dopamine_level1.78776736
26MP0002064_seizures1.77544118
27MP0004742_abnormal_vestibular_system1.77510516
28MP0001853_heart_inflammation1.74902412
29MP0009764_decreased_sensitivity_to1.74748897
30MP0005409_darkened_coat_color1.71404196
31MP0004947_skin_inflammation1.70064639
32MP0002272_abnormal_nervous_system1.69711243
33MP0003075_altered_response_to1.69710312
34MP0004142_abnormal_muscle_tone1.69677559
35MP0001845_abnormal_inflammatory_respons1.69276671
36MP0001486_abnormal_startle_reflex1.69050891
37MP0004859_abnormal_synaptic_plasticity1.68518875
38MP0002229_neurodegeneration1.65861157
39MP0002405_respiratory_system_inflammati1.65552896
40MP0003806_abnormal_nucleotide_metabolis1.63545448
41MP0001851_eye_inflammation1.62495313
42MP0008469_abnormal_protein_level1.58292682
43MP0005397_hematopoietic_system_phenotyp1.57551010
44MP0001545_abnormal_hematopoietic_system1.57551010
45MP0008004_abnormal_stomach_pH1.55657150
46MP0003631_nervous_system_phenotype1.51609592
47MP0003183_abnormal_peptide_metabolism1.51523735
48MP0003448_altered_tumor_morphology1.50094946
49MP0009333_abnormal_splenocyte_physiolog1.46915380
50MP0005167_abnormal_blood-brain_barrier1.45746693
51MP0003633_abnormal_nervous_system1.44991561
52MP0005000_abnormal_immune_tolerance1.44061612
53MP0003136_yellow_coat_color1.43886300
54MP0002148_abnormal_hypersensitivity_rea1.40415473
55MP0010155_abnormal_intestine_physiology1.39791988
56MP0001835_abnormal_antigen_presentation1.39009068
57MP0000858_altered_metastatic_potential1.38012199
58MP0005410_abnormal_fertilization1.37880871
59MP0010678_abnormal_skin_adnexa1.35502204
60MP0003436_decreased_susceptibility_to1.32172152
61MP0003191_abnormal_cellular_cholesterol1.32158456
62MP0003453_abnormal_keratinocyte_physiol1.28498069
63MP0002734_abnormal_mechanical_nocicepti1.28373339
64MP0003195_calcinosis1.27624237
65MP0004510_myositis1.27005603
66MP0001970_abnormal_pain_threshold1.25053719
67MP0004381_abnormal_hair_follicle1.23934847
68MP0000716_abnormal_immune_system1.22712894
69MP0009046_muscle_twitch1.19098225
70MP0000747_muscle_weakness1.18608095
71MP0002254_reproductive_system_inflammat1.16627288
72MP0000383_abnormal_hair_follicle1.16415810
73MP0003828_pulmonary_edema1.15978016
74MP0005310_abnormal_salivary_gland1.12934301
75MP0001790_abnormal_immune_system1.11993325
76MP0005387_immune_system_phenotype1.11993325
77MP0001533_abnormal_skeleton_physiology1.11805029
78MP0003656_abnormal_erythrocyte_physiolo1.10230622
79MP0009745_abnormal_behavioral_response1.09868445
80MP0002090_abnormal_vision1.09781544
81MP0002295_abnormal_pulmonary_circulatio1.09653730
82MP0005025_abnormal_response_to1.07846716
83MP0000778_abnormal_nervous_system1.07668726
84MP0004134_abnormal_chest_morphology1.03436979
85MP0002723_abnormal_immune_serum1.02425159
86MP0005423_abnormal_somatic_nervous1.02414862
87MP0002877_abnormal_melanocyte_morpholog1.01307434
88MP0003635_abnormal_synaptic_transmissio1.01109081
89MP0002452_abnormal_antigen_presenting0.99776533
90MP0006054_spinal_hemorrhage0.99253134
91MP0005408_hypopigmentation0.97163180
92MP0002398_abnormal_bone_marrow0.95401930
93MP0002733_abnormal_thermal_nociception0.94926532
94MP0005647_abnormal_sex_gland0.94048318
95MP0002572_abnormal_emotion/affect_behav0.93414839
96MP0002429_abnormal_blood_cell0.93271913
97MP0000689_abnormal_spleen_morphology0.92495402
98MP0005464_abnormal_platelet_physiology0.90390124
99MP0000465_gastrointestinal_hemorrhage0.89925205
100MP0002138_abnormal_hepatobiliary_system0.89147202
101MP0002933_joint_inflammation0.89124951
102MP0002736_abnormal_nociception_after0.88890820
103MP0003300_gastrointestinal_ulcer0.86837377
104MP0005166_decreased_susceptibility_to0.85914985
105MP0008438_abnormal_cutaneous_collagen0.85864857
106MP0009763_increased_sensitivity_to0.85359983
107MP0002066_abnormal_motor_capabilities/c0.85279822
108MP0000955_abnormal_spinal_cord0.84920099
109MP0002882_abnormal_neuron_morphology0.84115697
110MP0004883_abnormal_blood_vessel0.82651461
111MP0002735_abnormal_chemical_nociception0.82646202
112MP0002722_abnormal_immune_system0.81777648
113MP0001968_abnormal_touch/_nociception0.81677919
114MP0003091_abnormal_cell_migration0.80868901
115MP0001440_abnormal_grooming_behavior0.79996833
116MP0001800_abnormal_humoral_immune0.79803657
117MP0002067_abnormal_sensory_capabilities0.79778168
118MP0001958_emphysema0.79187053
119MP0005365_abnormal_bile_salt0.79050652
120MP0000343_altered_response_to0.78969335
121MP0010307_abnormal_tumor_latency0.78862431
122MP0008569_lethality_at_weaning0.78625061
123MP0005165_increased_susceptibility_to0.77957543
124MP0001299_abnormal_eye_distance/0.77860375
125MP0001542_abnormal_bone_strength0.77041563
126MP0001485_abnormal_pinna_reflex0.76405795
127MP0002420_abnormal_adaptive_immunity0.75780076
128MP0002063_abnormal_learning/memory/cond0.75322415
129MP0001819_abnormal_immune_cell0.75171541
130MP0005164_abnormal_response_to0.74813235
131MP0008874_decreased_physiological_sensi0.74738977
132MP0005390_skeleton_phenotype0.73947153
133MP0001963_abnormal_hearing_physiology0.72409436
134MP0003795_abnormal_bone_structure0.72136085
135MP0002332_abnormal_exercise_endurance0.70625804
136MP0000371_diluted_coat_color0.70068833
137MP0000015_abnormal_ear_pigmentation0.69953087
138MP0004043_abnormal_pH_regulation0.69148314
139MP0003724_increased_susceptibility_to0.67677732
140MP0003279_aneurysm0.67537382
141MP0005671_abnormal_response_to0.67354344
142MP0000733_abnormal_muscle_development0.67106147
143MP0004185_abnormal_adipocyte_glucose0.67063878
144MP0005076_abnormal_cell_differentiation0.66481758
145MP0002998_abnormal_bone_remodeling0.66311229
146MP0000249_abnormal_blood_vessel0.64940777
147MP0009115_abnormal_fat_cell0.64268206
148MP0001663_abnormal_digestive_system0.61856942
149MP0001849_ear_inflammation0.61354066
150MP0000609_abnormal_liver_physiology0.59655387
151MP0005319_abnormal_enzyme/_coenzyme0.59602751
152MP0003705_abnormal_hypodermis_morpholog0.59183392
153MP0009765_abnormal_xenobiotic_induced0.58460476
154MP0005257_abnormal_intraocular_pressure0.57608154
155MP0003879_abnormal_hair_cell0.55104866

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.25828184
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.50294051
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.50294051
4Axonal loss (HP:0003447)5.45020364
5Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.19117132
6Increased cerebral lipofuscin (HP:0011813)4.76938911
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.54428209
8Cerebral inclusion bodies (HP:0100314)4.46169569
9Peripheral hypomyelination (HP:0007182)4.35446403
10Supranuclear gaze palsy (HP:0000605)4.34619647
11Systemic lupus erythematosus (HP:0002725)4.31332360
12Abnormality of liposaccharide metabolism (HP:0010968)4.18346892
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.18346892
14Abnormality of glycolipid metabolism (HP:0010969)4.18346892
15Onion bulb formation (HP:0003383)4.07462177
16Abnormality of the corticospinal tract (HP:0002492)4.04486194
17Vacuolated lymphocytes (HP:0001922)3.81432520
18Segmental peripheral demyelination/remyelination (HP:0003481)3.67008164
19Dysostosis multiplex (HP:0000943)3.65442205
20Parakeratosis (HP:0001036)3.59364792
21Recurrent abscess formation (HP:0002722)3.45468341
22Abnormality of macrophages (HP:0004311)3.43448485
23Mediastinal lymphadenopathy (HP:0100721)3.39829277
24Insidious onset (HP:0003587)3.36384871
25Termporal pattern (HP:0011008)3.36384871
26Peripheral demyelination (HP:0011096)3.32795013
27Hepatosplenomegaly (HP:0001433)3.31119671
28Glomerulonephritis (HP:0000099)3.26048958
29Loss of speech (HP:0002371)3.25061611
30Autoimmune thrombocytopenia (HP:0001973)3.20858475
31Slow saccadic eye movements (HP:0000514)3.18081942
32Recurrent bacterial skin infections (HP:0005406)3.16430776
33Orchitis (HP:0100796)3.15381561
34Abnormal auditory evoked potentials (HP:0006958)3.11959630
35Agnosia (HP:0010524)3.11369946
36Myositis (HP:0100614)3.08643442
37Nuclear cataract (HP:0100018)3.06653183
38Retrobulbar optic neuritis (HP:0100654)3.06456975
39Optic neuritis (HP:0100653)3.06456975
40Upper motor neuron abnormality (HP:0002127)3.05385927
41Neuronal loss in central nervous system (HP:0002529)2.96560040
42Clumsiness (HP:0002312)2.94605150
43Myocardial infarction (HP:0001658)2.77157173
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.76353931
45Ankle clonus (HP:0011448)2.74664509
46Spastic tetraparesis (HP:0001285)2.72936408
47Progressive neurologic deterioration (HP:0002344)2.69581044
48Disinhibition (HP:0000734)2.69485833
49Spastic gait (HP:0002064)2.66555532
50Intention tremor (HP:0002080)2.66400562
51Amyloidosis (HP:0011034)2.64287555
52Abnormality of the vasculature of the conjunctiva (HP:0008054)2.63836885
53Stomatitis (HP:0010280)2.63499183
54J-shaped sella turcica (HP:0002680)2.62727915
55Purpura (HP:0000979)2.62679162
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.59945436
57Mutism (HP:0002300)2.59877712
58Dysmetria (HP:0001310)2.59147712
59Hematochezia (HP:0002573)2.57997512
60Spontaneous hematomas (HP:0007420)2.56246362
61Inappropriate behavior (HP:0000719)2.55398908
62Myokymia (HP:0002411)2.55170539
63Sensory axonal neuropathy (HP:0003390)2.53997335
64Cerebral hypomyelination (HP:0006808)2.50207943
65Increased serum ferritin (HP:0003281)2.44568448
66Personality changes (HP:0000751)2.39506330
67Recurrent fungal infections (HP:0002841)2.34416320
68Cerebral hemorrhage (HP:0001342)2.33662105
69Thoracic kyphosis (HP:0002942)2.30367598
70Urinary glycosaminoglycan excretion (HP:0003541)2.28822034
71Mucopolysacchariduria (HP:0008155)2.28822034
72Urinary incontinence (HP:0000020)2.27131138
73Recurrent skin infections (HP:0001581)2.26285055
74Dementia (HP:0000726)2.23170076
75Gingivitis (HP:0000230)2.22903295
76Metaphyseal irregularity (HP:0003025)2.22164548
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21615205
78Abnormality of polysaccharide metabolism (HP:0011012)2.21615205
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21615205
80Foot dorsiflexor weakness (HP:0009027)2.18655607
81Eczematoid dermatitis (HP:0000976)2.17623625
82Hemoptysis (HP:0002105)2.16122677
83Global brain atrophy (HP:0002283)2.14495732
84Basal ganglia calcification (HP:0002135)2.12987464
85Pulmonary infiltrates (HP:0002113)2.11837415
86Polyneuropathy (HP:0001271)2.11754867
87Pathologic fracture (HP:0002756)2.11290731
88Recurrent cutaneous fungal infections (HP:0011370)2.10881637
89Chronic mucocutaneous candidiasis (HP:0002728)2.10881637
90Asymmetric septal hypertrophy (HP:0001670)2.10553400
91Leukodystrophy (HP:0002415)2.08776512
92Cardiomegaly (HP:0001640)2.08469765
93Meningitis (HP:0001287)2.06569151
94Stridor (HP:0010307)2.05937358
95Complement deficiency (HP:0004431)2.05394814
96Recurrent gram-negative bacterial infections (HP:0005420)2.05387758
97Keratoconjunctivitis sicca (HP:0001097)2.04621961
98Akinesia (HP:0002304)2.03929923
99Muscle fiber splitting (HP:0003555)2.03888170
100Hypoplastic pelvis (HP:0008839)2.03328287
101Bone pain (HP:0002653)2.00260642
102Apathy (HP:0000741)1.98710788
103Elevated erythrocyte sedimentation rate (HP:0003565)1.98149831
104Paraparesis (HP:0002385)1.96769331
105Vasculitis (HP:0002633)1.96647767
106Scanning speech (HP:0002168)1.94995684
107Retinal atrophy (HP:0001105)1.94327586
108Recurrent viral infections (HP:0004429)1.93820898
109Urticaria (HP:0001025)1.93395694
110Petechiae (HP:0000967)1.93386318
111Abnormality of the foot musculature (HP:0001436)1.92961014
112Thick nail (HP:0001805)1.92459147
113Decreased motor nerve conduction velocity (HP:0003431)1.91683947
114Obstructive lung disease (HP:0006536)1.90717810
115Chronic obstructive pulmonary disease (HP:0006510)1.90717810
116Arterial tortuosity (HP:0005116)1.88797975
117Abnormality of iron homeostasis (HP:0011031)1.88321014
118Progressive visual loss (HP:0000529)1.88066660
119Memory impairment (HP:0002354)1.87355386
120Increased CSF protein (HP:0002922)1.87135526
121Anteriorly placed anus (HP:0001545)1.86275117
122Esophageal varix (HP:0002040)1.86195474
123Gowers sign (HP:0003391)1.83774628
124Metabolic alkalosis (HP:0200114)1.82510998
125Keratoconjunctivitis (HP:0001096)1.82482264
126Prolonged neonatal jaundice (HP:0006579)1.82321777
127Protuberant abdomen (HP:0001538)1.82314306
128T lymphocytopenia (HP:0005403)1.81751491
129Malnutrition (HP:0004395)1.81547472
130Abnormality of complement system (HP:0005339)1.80915171
131Abnormality of the periventricular white matter (HP:0002518)1.80640730
132Retinal dysplasia (HP:0007973)1.80250690
133Increased IgM level (HP:0003496)1.79506763
134Prostate neoplasm (HP:0100787)1.79199303
135Interstitial pulmonary disease (HP:0006530)1.78652349
136Lower limb muscle weakness (HP:0007340)1.78246311
137Alacrima (HP:0000522)1.77918921
138Action tremor (HP:0002345)1.76340242
139Colitis (HP:0002583)1.75121367
140Encephalitis (HP:0002383)1.74971043
141Morphological abnormality of the inner ear (HP:0011390)1.72685999
142Abnormal large intestine physiology (HP:0012700)1.72307778
143Spastic paraparesis (HP:0002313)1.72047016
144Diminished motivation (HP:0000745)1.71896515
145Autoamputation (HP:0001218)1.70933027
146Distal sensory impairment (HP:0002936)1.69488482
147Nausea (HP:0002018)1.68860273
148Hammertoe (HP:0001765)1.66714057
149CNS hypomyelination (HP:0003429)1.65407830
150Congenital ichthyosiform erythroderma (HP:0007431)1.63903580
151Diplopia (HP:0000651)1.60935776
152Abnormality of binocular vision (HP:0011514)1.60935776
153Urinary urgency (HP:0000012)1.60930482
154Abnormality of the lumbar spine (HP:0100712)1.60568919
155Progressive inability to walk (HP:0002505)1.59552685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.03147264
2EPHB14.20812617
3IRAK34.08368860
4NME23.40613107
5MAPKAPK53.38239216
6OXSR13.28637748
7TESK22.86714370
8PKN12.74002097
9PBK2.51179601
10TAOK22.13644891
11MATK2.07045459
12DDR22.01565253
13MET2.00426215
14FGR1.87201804
15BLK1.85417944
16ERN11.82582330
17IRAK41.82450837
18CLK11.76484280
19MOS1.74041539
20MAP2K31.73008983
21MAP3K131.72799791
22LIMK11.71932985
23ARAF1.69703637
24MAP3K31.67557288
25MAP3K111.66289164
26BCR1.60093217
27WNK11.58712605
28NTRK11.58624674
29IKBKB1.58308543
30WNK41.54228136
31PRPF4B1.52610142
32CDC42BPA1.50479793
33JAK31.47393390
34CSNK1A1L1.47337751
35RIPK41.46118078
36ZAP701.45897887
37GRK71.45347604
38TAOK11.43607487
39UHMK11.42565825
40CSNK1G31.41503478
41PIM21.39946887
42CSF1R1.32802640
43IKBKE1.30578256
44SGK2231.29275595
45SGK4941.29275595
46MST41.27164327
47CAMKK21.27032350
48RIPK11.25529578
49CAMK1G1.15882915
50TESK11.15078878
51CDK191.14599397
52CSNK1G21.14139585
53CAMK2B1.13164799
54CASK1.13004874
55KIT1.11256575
56MAPK151.11115851
57NEK91.09622446
58KSR21.08988374
59SYK1.02899876
60FES1.02833854
61ACVR1B1.02589248
62CSNK1G11.02420585
63ROCK21.02302838
64MAP3K91.00729991
65TRIB31.00382800
66TAOK30.98456251
67PNCK0.95976111
68CAMK2D0.94744359
69TXK0.94073766
70CDK60.93964452
71TRPM70.91358405
72MAP3K50.91044743
73CAMK1D0.90512305
74NEK60.90123791
75PDPK10.86430105
76MUSK0.85891734
77IRAK20.85846187
78DAPK20.85564713
79MARK20.84381492
80TYK20.84086821
81PRKD10.82655800
82FGFR20.78310410
83FYN0.76128150
84MARK30.75872530
85CHUK0.75411126
86BMPR20.75311561
87BMPR1B0.74979098
88CDK50.72494178
89BTK0.72046121
90HCK0.70799612
91CAMK2G0.70734316
92TTN0.69303149
93LCK0.69105983
94TGFBR20.69008473
95PAK40.68628929
96PAK60.67376506
97CAMK2A0.66585947
98STK100.66556157
99ICK0.63788148
100PRKCQ0.63486099
101DYRK20.62890525
102DMPK0.62116106
103PDK10.61581792
104MAPK70.61342364
105TNK20.60683736
106RPS6KL10.59658758
107RPS6KC10.59658758
108ERBB40.59646975
109GSK3A0.57940836
110TBK10.57096282
111PRKCE0.56637489
112RPS6KA20.55823382
113MAP2K20.54891698
114TYRO30.54311994
115CDK140.54112716
116CSK0.53965730
117DAPK30.53187023
118RPS6KA50.52992224
119SCYL20.52580827
120SIK30.51786302
121ITK0.51152924
122PRKCH0.49968650
123GRK50.49112556
124CDK150.48536266
125CAMKK10.48121551
126PRKG10.47181193
127MAP2K60.47018656
128BMX0.46894023
129RPS6KA60.45343681
130MAP3K140.45091549
131MAP3K80.44929256
132JAK10.44198890
133MAPK120.44183892
134MAP3K60.44134479
135PIM10.43925842
136ABL20.43700458
137MAP4K10.42983954
138CDK180.41990760
139PHKG10.41767334
140PHKG20.41767334
141ABL10.40626094
142LYN0.40056837
143PDK20.40036571
144EGFR0.39812510
145PRKD30.39528521
146MAP3K10.39378255
147ADRBK20.39041990
148JAK20.38266724
149MAPK40.37440454
150IRAK10.36494811
151PDGFRA0.34472465
152SGK30.32816414
153PRKG20.30547339
154MAPKAPK20.29578229
155KSR10.29026185
156SMG10.28924689

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.20378620
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.08533175
3Fatty acid elongation_Homo sapiens_hsa000623.12747157
4Lysosome_Homo sapiens_hsa041422.81330523
5Ether lipid metabolism_Homo sapiens_hsa005652.80541990
6Staphylococcus aureus infection_Homo sapiens_hsa051502.68146273
7Allograft rejection_Homo sapiens_hsa053302.44000826
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32203453
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.30640924
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29900644
11Graft-versus-host disease_Homo sapiens_hsa053322.01394060
12Autoimmune thyroid disease_Homo sapiens_hsa053202.00381701
13Other glycan degradation_Homo sapiens_hsa005111.98096723
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92886804
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.91577915
16Sphingolipid metabolism_Homo sapiens_hsa006001.90820536
17Nitrogen metabolism_Homo sapiens_hsa009101.86333642
18Antigen processing and presentation_Homo sapiens_hsa046121.83921405
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.82749513
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80269857
21Legionellosis_Homo sapiens_hsa051341.79827683
22Phagosome_Homo sapiens_hsa041451.79784981
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70781362
24Hematopoietic cell lineage_Homo sapiens_hsa046401.60224283
25Type I diabetes mellitus_Homo sapiens_hsa049401.59849390
26TNF signaling pathway_Homo sapiens_hsa046681.58510176
27Toxoplasmosis_Homo sapiens_hsa051451.57501173
28Histidine metabolism_Homo sapiens_hsa003401.56131827
29Vitamin B6 metabolism_Homo sapiens_hsa007501.47910462
30Pertussis_Homo sapiens_hsa051331.43676239
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40420862
32Influenza A_Homo sapiens_hsa051641.36810303
33Rheumatoid arthritis_Homo sapiens_hsa053231.36756804
34Linoleic acid metabolism_Homo sapiens_hsa005911.35332517
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34716168
36Collecting duct acid secretion_Homo sapiens_hsa049661.29790861
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29207109
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29082265
39Viral myocarditis_Homo sapiens_hsa054161.26978412
40Sphingolipid signaling pathway_Homo sapiens_hsa040711.24016329
41Prion diseases_Homo sapiens_hsa050201.22614743
42Renal cell carcinoma_Homo sapiens_hsa052111.14676365
43Osteoclast differentiation_Homo sapiens_hsa043801.10947762
44Endocytosis_Homo sapiens_hsa041441.08653645
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08349886
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07130501
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06441249
48Malaria_Homo sapiens_hsa051441.06375378
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04378207
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03920524
51Measles_Homo sapiens_hsa051621.02434741
52African trypanosomiasis_Homo sapiens_hsa051431.00250407
53Chemokine signaling pathway_Homo sapiens_hsa040620.98815454
54Herpes simplex infection_Homo sapiens_hsa051680.97353782
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96917117
56Vibrio cholerae infection_Homo sapiens_hsa051100.93370945
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92473500
58Axon guidance_Homo sapiens_hsa043600.92468199
59Leishmaniasis_Homo sapiens_hsa051400.92430107
60Serotonergic synapse_Homo sapiens_hsa047260.92407937
61B cell receptor signaling pathway_Homo sapiens_hsa046620.91794727
62Salmonella infection_Homo sapiens_hsa051320.91534294
63Mineral absorption_Homo sapiens_hsa049780.90453232
64Acute myeloid leukemia_Homo sapiens_hsa052210.89697847
65Tuberculosis_Homo sapiens_hsa051520.87976777
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.87338010
67Long-term depression_Homo sapiens_hsa047300.86872860
68Hepatitis C_Homo sapiens_hsa051600.85929971
69Dorso-ventral axis formation_Homo sapiens_hsa043200.85863153
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85226613
71Complement and coagulation cascades_Homo sapiens_hsa046100.84988157
72Ovarian steroidogenesis_Homo sapiens_hsa049130.84451248
73Apoptosis_Homo sapiens_hsa042100.83559266
74Glutamatergic synapse_Homo sapiens_hsa047240.83419515
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.82043459
76Sulfur metabolism_Homo sapiens_hsa009200.81929804
77GABAergic synapse_Homo sapiens_hsa047270.81433999
78Protein export_Homo sapiens_hsa030600.80373229
79Morphine addiction_Homo sapiens_hsa050320.79245233
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.77483740
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75975057
82Bladder cancer_Homo sapiens_hsa052190.75182472
83T cell receptor signaling pathway_Homo sapiens_hsa046600.74902230
84Hepatitis B_Homo sapiens_hsa051610.74573236
85Arachidonic acid metabolism_Homo sapiens_hsa005900.73907665
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71730211
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70498172
88Galactose metabolism_Homo sapiens_hsa000520.69638654
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64901757
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64531631
91Synaptic vesicle cycle_Homo sapiens_hsa047210.64000626
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.63514455
93Primary immunodeficiency_Homo sapiens_hsa053400.63186101
94Ras signaling pathway_Homo sapiens_hsa040140.63072529
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.62789306
96Shigellosis_Homo sapiens_hsa051310.60486588
97Epstein-Barr virus infection_Homo sapiens_hsa051690.60426649
98Cocaine addiction_Homo sapiens_hsa050300.60366450
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59849344
100PPAR signaling pathway_Homo sapiens_hsa033200.57096881
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55642371
102Prolactin signaling pathway_Homo sapiens_hsa049170.55260320
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51930871
104Oxidative phosphorylation_Homo sapiens_hsa001900.51854368
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.51719431
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51473303
107Arginine and proline metabolism_Homo sapiens_hsa003300.50339928
108Renin secretion_Homo sapiens_hsa049240.49606823
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49096785
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48995802
111Salivary secretion_Homo sapiens_hsa049700.48542954
112Gastric acid secretion_Homo sapiens_hsa049710.48379265
113Asthma_Homo sapiens_hsa053100.47997959
114Vitamin digestion and absorption_Homo sapiens_hsa049770.47325712
115HIF-1 signaling pathway_Homo sapiens_hsa040660.46391293
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43697258
117Amoebiasis_Homo sapiens_hsa051460.42668129
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41204362
119Cholinergic synapse_Homo sapiens_hsa047250.40974859
120Pancreatic cancer_Homo sapiens_hsa052120.40190417
121Inositol phosphate metabolism_Homo sapiens_hsa005620.40141780
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.40065657
123Fructose and mannose metabolism_Homo sapiens_hsa000510.39961809
124MAPK signaling pathway_Homo sapiens_hsa040100.39335460
125Choline metabolism in cancer_Homo sapiens_hsa052310.38762494
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37828581
127Alzheimers disease_Homo sapiens_hsa050100.36082401
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35899046
129Type II diabetes mellitus_Homo sapiens_hsa049300.35470308
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35232298
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.34798392
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34550408
133HTLV-I infection_Homo sapiens_hsa051660.33989656
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33958798
135Pancreatic secretion_Homo sapiens_hsa049720.33369298
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32426547
137Circadian entrainment_Homo sapiens_hsa047130.31945138
138ErbB signaling pathway_Homo sapiens_hsa040120.31835078
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31685887
140Platelet activation_Homo sapiens_hsa046110.30916612
141VEGF signaling pathway_Homo sapiens_hsa043700.30666203
142ABC transporters_Homo sapiens_hsa020100.30226981
143Tight junction_Homo sapiens_hsa045300.30142608
144Chronic myeloid leukemia_Homo sapiens_hsa052200.29985018
145Pentose phosphate pathway_Homo sapiens_hsa000300.26080127
146GnRH signaling pathway_Homo sapiens_hsa049120.25601615
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22996303
148Systemic lupus erythematosus_Homo sapiens_hsa053220.21932821
149Notch signaling pathway_Homo sapiens_hsa043300.21203324
150Insulin resistance_Homo sapiens_hsa049310.20769626
151Renin-angiotensin system_Homo sapiens_hsa046140.19503582
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19114911

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