KCNK15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory receptor cell differentiation (GO:0042491)9.57670697
2inner ear receptor cell development (GO:0060119)8.21591705
3post-embryonic morphogenesis (GO:0009886)8.07188598
4inner ear receptor stereocilium organization (GO:0060122)6.17647785
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.03209838
6viral transcription (GO:0019083)5.94690234
7translational termination (GO:0006415)5.80143300
8ribosomal small subunit biogenesis (GO:0042274)5.74522971
9inner ear receptor cell differentiation (GO:0060113)5.58526611
10hair cell differentiation (GO:0035315)5.45983074
11ATP synthesis coupled proton transport (GO:0015986)5.35684066
12energy coupled proton transport, down electrochemical gradient (GO:0015985)5.35684066
13response to gravity (GO:0009629)4.90161658
14mechanoreceptor differentiation (GO:0042490)4.82538468
15translational elongation (GO:0006414)4.79959266
16short-term memory (GO:0007614)4.67614270
17ribosomal small subunit assembly (GO:0000028)4.65517919
18cotranslational protein targeting to membrane (GO:0006613)4.59330373
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.57974106
20protein targeting to ER (GO:0045047)4.53357761
21superoxide anion generation (GO:0042554)4.52078176
22cellular protein complex disassembly (GO:0043624)4.41187431
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.31359338
24maturation of SSU-rRNA (GO:0030490)4.30867700
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.30714010
26viral life cycle (GO:0019058)4.29306497
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24980699
28protein localization to endoplasmic reticulum (GO:0070972)4.19114932
29positive regulation of dendritic spine morphogenesis (GO:0061003)4.17820350
30phenol-containing compound catabolic process (GO:0019336)4.17345018
31postsynaptic membrane organization (GO:0001941)4.17009580
32chaperone-mediated protein transport (GO:0072321)4.12948514
33amino sugar catabolic process (GO:0046348)4.12605673
34respiratory electron transport chain (GO:0022904)4.06313492
35electron transport chain (GO:0022900)4.03016294
36negative regulation of cytosolic calcium ion concentration (GO:0051481)4.01531592
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96634019
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.89222092
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.86337729
40protein complex disassembly (GO:0043241)3.85777249
41translational initiation (GO:0006413)3.74072949
42tooth mineralization (GO:0034505)3.62548399
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.61878216
44behavioral response to ethanol (GO:0048149)3.60659106
45macromolecular complex disassembly (GO:0032984)3.56214892
46GTP biosynthetic process (GO:0006183)3.53548148
47neurotransmitter catabolic process (GO:0042135)3.51059108
48glucocorticoid biosynthetic process (GO:0006704)3.46963450
49neuron cell-cell adhesion (GO:0007158)3.42845857
50dendritic spine morphogenesis (GO:0060997)3.39381648
51layer formation in cerebral cortex (GO:0021819)3.37160214
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34111563
53G-protein coupled receptor internalization (GO:0002031)3.33593264
54response to pH (GO:0009268)3.32980625
55UTP biosynthetic process (GO:0006228)3.26373258
56adenine nucleotide transport (GO:0051503)3.24055409
57regulation of glutamate receptor signaling pathway (GO:1900449)3.23710718
58cardiac right ventricle morphogenesis (GO:0003215)3.23256098
59mesenchymal to epithelial transition (GO:0060231)3.22597348
60cranial nerve morphogenesis (GO:0021602)3.20576495
61protein targeting to membrane (GO:0006612)3.20128988
62negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.15839293
63adenosine metabolic process (GO:0046085)3.15636988
64mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.13416066
65vocalization behavior (GO:0071625)3.12894622
66gamma-aminobutyric acid transport (GO:0015812)3.12150080
67UTP metabolic process (GO:0046051)3.07536013
68CTP biosynthetic process (GO:0006241)3.06205370
69CTP metabolic process (GO:0046036)3.06205370
70positive regulation of synapse assembly (GO:0051965)3.04848961
71positive regulation of protein dephosphorylation (GO:0035307)3.04379448
72regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.04051062
73cerebral cortex neuron differentiation (GO:0021895)3.03735481
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03529830
75hydrogen ion transmembrane transport (GO:1902600)3.00387213
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.99083381
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98725225
78cell proliferation in forebrain (GO:0021846)2.96599949
79purine nucleotide transport (GO:0015865)2.95603170
80purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95403475
81positive regulation of fatty acid beta-oxidation (GO:0032000)2.93394746
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91911843
83translation (GO:0006412)2.90311045
84pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.89209214
85import into cell (GO:0098657)2.88301539
86ribonucleoside triphosphate biosynthetic process (GO:0009201)2.88208564
87ATP biosynthetic process (GO:0006754)2.87734571
88ear development (GO:0043583)2.85455768
89positive regulation of dendritic spine development (GO:0060999)2.85389894
90middle ear morphogenesis (GO:0042474)2.85341511
91auditory receptor cell stereocilium organization (GO:0060088)2.84641643
92negative regulation of organelle assembly (GO:1902116)2.84627641
93N-acetylneuraminate metabolic process (GO:0006054)2.84589345
94cellular response to pH (GO:0071467)2.83877246
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.83627660
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78932563
97cerebral cortex radially oriented cell migration (GO:0021799)2.78896524
98opioid receptor signaling pathway (GO:0038003)2.78158121
99transcription elongation from RNA polymerase III promoter (GO:0006385)2.78032792
100termination of RNA polymerase III transcription (GO:0006386)2.78032792
101pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.77285142
102dorsal/ventral neural tube patterning (GO:0021904)2.76981351
103pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75578229
104activation of protein kinase B activity (GO:0032148)2.73649565
105potassium ion export (GO:0071435)2.73110627
106nuclear-transcribed mRNA catabolic process (GO:0000956)2.72994363
107negative regulation of catenin import into nucleus (GO:0035414)2.72177242
108purine ribonucleotide transport (GO:0015868)2.70079322
109cell-cell junction maintenance (GO:0045217)2.69621121
110locomotory exploration behavior (GO:0035641)2.68947218
111cell morphogenesis involved in neuron differentiation (GO:0048667)2.67852477
112pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.67352762
113positive regulation of gastrulation (GO:2000543)2.66978826
114cell wall macromolecule catabolic process (GO:0016998)2.66457478
115cell wall macromolecule metabolic process (GO:0044036)2.66457478
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66443269
117sympathetic nervous system development (GO:0048485)2.65339461
118glutamate receptor signaling pathway (GO:0007215)2.64870780
119axon extension involved in axon guidance (GO:0048846)2.63070634
120neuron projection extension involved in neuron projection guidance (GO:1902284)2.63070634
121neuronal action potential propagation (GO:0019227)2.62512019
122linoleic acid metabolic process (GO:0043651)2.62501809
123central nervous system projection neuron axonogenesis (GO:0021952)2.62311503
124negative regulation of adenylate cyclase activity (GO:0007194)2.62252031
125G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.60457351
126guanosine-containing compound biosynthetic process (GO:1901070)2.59717617
127response to parathyroid hormone (GO:0071107)2.59511400
128bone trabecula formation (GO:0060346)2.59446937
129axonal fasciculation (GO:0007413)2.59315899
130mRNA catabolic process (GO:0006402)2.59111126
131negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.58846806
132L-amino acid import (GO:0043092)2.58377184
133ribosomal large subunit biogenesis (GO:0042273)2.57991954
134phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.56226334
135regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56091374
136neurotransmitter-gated ion channel clustering (GO:0072578)2.55753837
137proton transport (GO:0015992)2.54845459
138positive regulation of membrane potential (GO:0045838)2.53591439
139cell migration in hindbrain (GO:0021535)2.52064686
140mesonephros development (GO:0001823)2.51899597
141diaphragm development (GO:0060539)2.51793687
142cerebellar Purkinje cell layer development (GO:0021680)2.51661773
143dopamine biosynthetic process (GO:0042416)2.51194357
144regulation of fatty acid beta-oxidation (GO:0031998)2.49999445
145detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.49038582
146detection of temperature stimulus involved in sensory perception (GO:0050961)2.49038582
147superoxide metabolic process (GO:0006801)2.48711659
148amino acid import (GO:0043090)2.47755073
149hydrogen transport (GO:0006818)2.47504818
150nucleoside triphosphate biosynthetic process (GO:0009142)2.47113929
151negative regulation of cyclase activity (GO:0031280)2.46661756
152sphingosine metabolic process (GO:0006670)2.46277991
153regulation of interleukin-5 production (GO:0032674)2.46193922
154regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45157597
155N-acetylglucosamine metabolic process (GO:0006044)2.44725099
156head development (GO:0060322)2.44720349
157negative regulation of cardiac muscle hypertrophy (GO:0010614)2.44669192
158protein complex biogenesis (GO:0070271)2.44609161
159ceramide catabolic process (GO:0046514)2.44410186
160establishment of protein localization to membrane (GO:0090150)2.43525513
161positive regulation of fatty acid oxidation (GO:0046321)2.42858262
162protein neddylation (GO:0045116)2.42658196
163dopaminergic neuron differentiation (GO:0071542)2.42350937
164dopamine receptor signaling pathway (GO:0007212)2.41985138
165regulation of neurotransmitter uptake (GO:0051580)2.41824975
166negative regulation of cAMP biosynthetic process (GO:0030818)2.41407950
167negative regulation of embryonic development (GO:0045992)2.40563762
168epithelial cell maturation (GO:0002070)2.40465151
169behavioral response to nicotine (GO:0035095)2.39503558
170inner mitochondrial membrane organization (GO:0007007)2.38829574
171axon extension (GO:0048675)2.38823105
172adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.38276031
173regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.38031365
174regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.38031365
175establishment or maintenance of monopolar cell polarity (GO:0061339)2.37850362
176establishment of monopolar cell polarity (GO:0061162)2.37850362
177righting reflex (GO:0060013)2.37459745
178negative regulation of homotypic cell-cell adhesion (GO:0034111)2.36931605
179protein localization to synapse (GO:0035418)2.36247051
180neuron recognition (GO:0008038)2.36236275
181sequestering of actin monomers (GO:0042989)2.36139738
182chemosensory behavior (GO:0007635)2.35717153
183ovulation cycle (GO:0042698)2.35172513
184endothelial cell chemotaxis (GO:0035767)2.34287890
185behavioral response to cocaine (GO:0048148)2.33759441
186auditory behavior (GO:0031223)2.32364924
187regulation of dendritic spine morphogenesis (GO:0061001)2.31310017
188regulation of synaptic transmission, glutamatergic (GO:0051966)2.30798673
189kidney mesenchyme development (GO:0072074)2.30575062
190negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.30366622
191branching involved in salivary gland morphogenesis (GO:0060445)2.30356509
192glycerophospholipid catabolic process (GO:0046475)2.30318546
193glial cell proliferation (GO:0014009)2.29460477
194cellular response to ammonium ion (GO:0071242)2.29040569
195positive regulation of catecholamine secretion (GO:0033605)2.27435621
196adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.27322679
197positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.26853437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.27604064
2EZH2_22144423_ChIP-Seq_EOC_Human3.50437166
3ESR1_15608294_ChIP-ChIP_MCF-7_Human3.24004566
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89428468
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81113353
6GBX2_23144817_ChIP-Seq_PC3_Human2.72285364
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71201650
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.61149663
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55589066
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55519233
11ZNF263_19887448_ChIP-Seq_K562_Human2.54828863
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53750598
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48932229
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48932229
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.48131083
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.45221472
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43199813
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.40092991
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35018723
20* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28529362
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26237957
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23083808
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14552732
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.12913636
25DROSHA_22980978_ChIP-Seq_HELA_Human2.12044013
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10351389
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.08850166
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08627217
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.98154739
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95399252
31AR_21572438_ChIP-Seq_LNCaP_Human1.94014275
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93837717
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.86233616
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83597313
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79721280
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77325357
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74392310
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.72686110
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70814137
40CTCF_27219007_Chip-Seq_Bcells_Human1.68808480
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63015705
42CTCF_18555785_ChIP-Seq_MESCs_Mouse1.62786356
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59741778
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59308860
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.58769698
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56473578
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55267643
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55101581
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54877185
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.53943346
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53679059
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53457144
53REST_21632747_ChIP-Seq_MESCs_Mouse1.52435785
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.50120899
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48813910
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48736198
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45545767
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44589938
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43387882
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42416125
61XRN2_22483619_ChIP-Seq_HELA_Human1.42347337
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41945211
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.41698506
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41571117
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39878903
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39550360
67LXR_22292898_ChIP-Seq_THP-1_Human1.39211930
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.37424381
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36518792
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.35543564
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.34945854
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.34138052
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.33737774
74P300_19829295_ChIP-Seq_ESCs_Human1.33580484
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32743024
76SMAD4_21799915_ChIP-Seq_A2780_Human1.32623103
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32035066
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31360766
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29394890
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.29296938
81RNF2_27304074_Chip-Seq_NSC_Mouse1.29008824
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28703138
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28668481
84TAF15_26573619_Chip-Seq_HEK293_Human1.27152665
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25664201
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25231495
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22487188
88TP53_18474530_ChIP-ChIP_U2OS_Human1.21486666
89* RUNX1_27514584_Chip-Seq_MCF-7_Human1.19513932
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.19330576
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18776214
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18746320
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18576385
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18141463
95* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17850568
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16690371
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.16174028
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15747502
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14082803
100* KDM2B_26808549_Chip-Seq_K562_Human1.13165569
101* NANOG_18555785_Chip-Seq_ESCs_Mouse1.13144321
102* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13113690
103STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12732595
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.12152322
105P53_22387025_ChIP-Seq_ESCs_Mouse1.11819423
106KDM2B_26808549_Chip-Seq_REH_Human1.11719606
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.11215937
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.11080143
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10289385
110* SA1_27219007_Chip-Seq_ERYTHROID_Human1.09465717
111P300_18555785_Chip-Seq_ESCs_Mouse1.08956767
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08841067
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08783285
114BCAT_22108803_ChIP-Seq_LS180_Human1.08681720
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08051588
116* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07845627
117* STAT3_18555785_Chip-Seq_ESCs_Mouse1.07723092
118RUNX2_22187159_ChIP-Seq_PCA_Human1.06694031
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.06224990
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06192864
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.06113030
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05714254
123TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05686754
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05300882
125FOXP1_21924763_ChIP-Seq_HESCs_Human1.05076918
126* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04703672
127TP53_20018659_ChIP-ChIP_R1E_Mouse1.04236035
128FLI1_27457419_Chip-Seq_LIVER_Mouse1.02890949
129EP300_21415370_ChIP-Seq_HL-1_Mouse1.02770433
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02700368
131RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02685343
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02301704
133* KLF4_18555785_Chip-Seq_ESCs_Mouse1.02234462
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.01997670
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01989620
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01159159
137CTCF_26484167_Chip-Seq_Bcells_Mouse1.00828902
138* P68_20966046_ChIP-Seq_HELA_Human1.00730467
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00715111
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00415488
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00184340
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99742549
143VDR_22108803_ChIP-Seq_LS180_Human0.99500961
144PU1_27457419_Chip-Seq_LIVER_Mouse0.99486776
145CREB1_26743006_Chip-Seq_LNCaP_Human0.99452342
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98910627
147ZNF274_21170338_ChIP-Seq_K562_Hela0.97958681
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97385516
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.97275994
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96210540
151* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96038539
152REST_18959480_ChIP-ChIP_MESCs_Mouse0.96026174
153* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95751936
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95412621
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.95384414
156ZFX_18555785_Chip-Seq_ESCs_Mouse0.95371544
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95042156
158* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94872630
159TTF2_22483619_ChIP-Seq_HELA_Human0.94842339
160KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94245399
161AHR_22903824_ChIP-Seq_MCF-7_Human0.94116146
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93140551
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92854083
164SMC4_20622854_ChIP-Seq_HELA_Human0.92190803
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92162478
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91660867
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91660867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004742_abnormal_vestibular_system5.92593690
2MP0009379_abnormal_foot_pigmentation4.48948703
3MP0002102_abnormal_ear_morphology3.61355997
4MP0001486_abnormal_startle_reflex3.55055113
5MP0005451_abnormal_body_composition3.51379709
6MP0010030_abnormal_orbit_morphology3.20627719
7MP0004859_abnormal_synaptic_plasticity3.14044633
8MP0003123_paternal_imprinting2.99694323
9MP0003136_yellow_coat_color2.57541573
10MP0001968_abnormal_touch/_nociception2.40253225
11MP0000383_abnormal_hair_follicle2.37943387
12MP0009046_muscle_twitch2.35449106
13MP0009745_abnormal_behavioral_response2.32973539
14MP0002139_abnormal_hepatobiliary_system2.32388966
15MP0001501_abnormal_sleep_pattern2.31348748
16MP0008995_early_reproductive_senescence2.19533830
17MP0003635_abnormal_synaptic_transmissio2.17656058
18MP0003880_abnormal_central_pattern2.15688152
19MP0002272_abnormal_nervous_system2.09550059
20MP0000647_abnormal_sebaceous_gland1.97033658
21MP0004381_abnormal_hair_follicle1.96199997
22MP0002653_abnormal_ependyma_morphology1.94587513
23MP0005623_abnormal_meninges_morphology1.90553598
24MP0002067_abnormal_sensory_capabilities1.88016131
25MP0003942_abnormal_urinary_system1.86357865
26MP0000026_abnormal_inner_ear1.84184231
27MP0001188_hyperpigmentation1.83901082
28MP0010678_abnormal_skin_adnexa1.75622466
29MP0001963_abnormal_hearing_physiology1.73421161
30MP0000537_abnormal_urethra_morphology1.69414060
31MP0002254_reproductive_system_inflammat1.68257524
32MP0002572_abnormal_emotion/affect_behav1.67352029
33MP0001502_abnormal_circadian_rhythm1.67132547
34MP0000566_synostosis1.65974241
35MP0000534_abnormal_ureter_morphology1.63910572
36MP0005377_hearing/vestibular/ear_phenot1.61155698
37MP0003878_abnormal_ear_physiology1.61155698
38MP0003122_maternal_imprinting1.60996020
39MP0002064_seizures1.60214525
40MP0002063_abnormal_learning/memory/cond1.59128002
41MP0006292_abnormal_olfactory_placode1.56557109
42MP0002184_abnormal_innervation1.54487585
43MP0002796_impaired_skin_barrier1.51638578
44MP0004858_abnormal_nervous_system1.51178421
45MP0002557_abnormal_social/conspecific_i1.49781593
46MP0004133_heterotaxia1.48597862
47MP0004270_analgesia1.45716485
48MP0003705_abnormal_hypodermis_morpholog1.45248210
49MP0006072_abnormal_retinal_apoptosis1.43682983
50MP0002733_abnormal_thermal_nociception1.42440274
51MP0000579_abnormal_nail_morphology1.42384802
52MP0005187_abnormal_penis_morphology1.42278646
53MP0002938_white_spotting1.36623952
54MP0002233_abnormal_nose_morphology1.35911277
55MP0009384_cardiac_valve_regurgitation1.33438060
56MP0001905_abnormal_dopamine_level1.31131364
57MP0004142_abnormal_muscle_tone1.30596266
58MP0003011_delayed_dark_adaptation1.30484201
59MP0000538_abnormal_urinary_bladder1.29466406
60MP0005535_abnormal_body_temperature1.24862981
61MP0004019_abnormal_vitamin_homeostasis1.24803838
62MP0001919_abnormal_reproductive_system1.23616419
63MP0003938_abnormal_ear_development1.23225459
64MP0001293_anophthalmia1.23031959
65MP0002249_abnormal_larynx_morphology1.21025579
66MP0001529_abnormal_vocalization1.19377993
67MP0002752_abnormal_somatic_nervous1.19340105
68MP0003121_genomic_imprinting1.18493183
69MP0009053_abnormal_anal_canal1.17656965
70MP0005645_abnormal_hypothalamus_physiol1.17504062
71MP0002697_abnormal_eye_size1.17284756
72MP0001440_abnormal_grooming_behavior1.17045946
73MP0002160_abnormal_reproductive_system1.16254208
74MP0002090_abnormal_vision1.15478355
75MP0000955_abnormal_spinal_cord1.13728427
76MP0008438_abnormal_cutaneous_collagen1.12974409
77MP0001970_abnormal_pain_threshold1.12818443
78MP0005423_abnormal_somatic_nervous1.12522799
79MP0002735_abnormal_chemical_nociception1.11443357
80MP0002116_abnormal_craniofacial_bone1.09741143
81MP0001485_abnormal_pinna_reflex1.09688119
82MP0003941_abnormal_skin_development1.09508518
83MP0002108_abnormal_muscle_morphology1.09112736
84MP0000750_abnormal_muscle_regeneration1.08681226
85MP0002822_catalepsy1.08072720
86MP0005551_abnormal_eye_electrophysiolog1.07454058
87MP0005508_abnormal_skeleton_morphology1.07297380
88MP0006276_abnormal_autonomic_nervous1.06879820
89MP0003186_abnormal_redox_activity1.06427464
90MP0003879_abnormal_hair_cell1.05309994
91MP0005503_abnormal_tendon_morphology1.04852268
92MP0002734_abnormal_mechanical_nocicepti1.04797739
93MP0002098_abnormal_vibrissa_morphology1.03745819
94MP0003937_abnormal_limbs/digits/tail_de1.03376839
95MP0005409_darkened_coat_color1.03056991
96MP0000462_abnormal_digestive_system1.02943227
97MP0000049_abnormal_middle_ear1.01224739
98MP0001664_abnormal_digestion0.99949302
99MP0003283_abnormal_digestive_organ0.99394204
100MP0005501_abnormal_skin_physiology0.99360220
101MP0009250_abnormal_appendicular_skeleto0.98634339
102MP0000631_abnormal_neuroendocrine_gland0.98118113
103MP0002066_abnormal_motor_capabilities/c0.97166140
104MP0002736_abnormal_nociception_after0.96653829
105MP0000427_abnormal_hair_cycle0.96252030
106MP0002837_dystrophic_cardiac_calcinosis0.95791601
107MP0003787_abnormal_imprinting0.94565997
108MP0005394_taste/olfaction_phenotype0.94323977
109MP0005499_abnormal_olfactory_system0.94323977
110MP0002932_abnormal_joint_morphology0.94063312
111MP0003045_fibrosis0.92523228
112MP0003936_abnormal_reproductive_system0.91111866
113MP0001286_abnormal_eye_development0.90245451
114MP0000778_abnormal_nervous_system0.89722493
115MP0003861_abnormal_nervous_system0.89500985
116MP0010771_integument_phenotype0.89004811
117MP0002882_abnormal_neuron_morphology0.87905360
118MP0005083_abnormal_biliary_tract0.87860122
119MP0003890_abnormal_embryonic-extraembry0.87815249
120MP0003690_abnormal_glial_cell0.87661750
121MP0003137_abnormal_impulse_conducting0.87337660
122MP0000678_abnormal_parathyroid_gland0.87210004
123MP0004885_abnormal_endolymph0.86804974
124MP0002277_abnormal_respiratory_mucosa0.86568879
125MP0003755_abnormal_palate_morphology0.85698593
126MP0008874_decreased_physiological_sensi0.84899764
127MP0005076_abnormal_cell_differentiation0.82480532
128MP0001661_extended_life_span0.80960371
129MP0002909_abnormal_adrenal_gland0.80803604
130MP0005389_reproductive_system_phenotype0.80130512
131MP0005379_endocrine/exocrine_gland_phen0.80013548
132MP0008569_lethality_at_weaning0.79247563
133MP0003935_abnormal_craniofacial_develop0.76885484
134MP0000467_abnormal_esophagus_morphology0.76825793
135MP0003638_abnormal_response/metabolism_0.76479311
136MP0001340_abnormal_eyelid_morphology0.76431643
137MP0003315_abnormal_perineum_morphology0.76170578
138MP0000751_myopathy0.75801853
139MP0002089_abnormal_postnatal_growth/wei0.75581448
140MP0002152_abnormal_brain_morphology0.75466746
141MP0005174_abnormal_tail_pigmentation0.75042178
142MP0005275_abnormal_skin_tensile0.74159940
143MP0005386_behavior/neurological_phenoty0.73529963
144MP0004924_abnormal_behavior0.73529963
145MP0002069_abnormal_eating/drinking_beha0.72673477
146MP0001986_abnormal_taste_sensitivity0.72155272
147MP0005248_abnormal_Harderian_gland0.69074042
148MP0002751_abnormal_autonomic_nervous0.68283993
149MP0002229_neurodegeneration0.68106748

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)8.54518304
2Duplicated collecting system (HP:0000081)7.36255554
3Chromsome breakage (HP:0040012)7.12188190
4Bilateral sensorineural hearing impairment (HP:0008619)7.00512434
5Abnormality of the renal collecting system (HP:0004742)6.37804219
6Abnormality of dentin (HP:0010299)6.30354939
7Focal motor seizures (HP:0011153)5.51917009
8Reticulocytopenia (HP:0001896)4.65770837
9Abnormality of the dental pulp (HP:0006479)4.47466675
10Duplication of thumb phalanx (HP:0009942)4.42201934
11Abnormality of cells of the erythroid lineage (HP:0012130)4.36164556
12Abnormality of DNA repair (HP:0003254)4.24702109
13Abnormality of pyrimidine metabolism (HP:0004353)4.18297917
14Abnormal number of erythroid precursors (HP:0012131)4.14874770
15Upper limb muscle weakness (HP:0003484)4.02162895
16Macrocytic anemia (HP:0001972)3.73026089
17Broad metatarsal (HP:0001783)3.58652712
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.51224537
19Congenital stationary night blindness (HP:0007642)3.39663140
20Renal Fanconi syndrome (HP:0001994)3.37424872
21Ureteral duplication (HP:0000073)3.34502041
22Increased hepatocellular lipid droplets (HP:0006565)3.23891799
23Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17242528
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.14495147
25Distal lower limb amyotrophy (HP:0008944)3.12515296
26Visual hallucinations (HP:0002367)3.11813399
27Acute necrotizing encephalopathy (HP:0006965)3.06885218
28Tinnitus (HP:0000360)3.06476124
29Abnormal mitochondria in muscle tissue (HP:0008316)2.99941989
30Testicular atrophy (HP:0000029)2.97433503
31Lower limb amyotrophy (HP:0007210)2.91880269
32Decreased central vision (HP:0007663)2.80296303
33Maternal diabetes (HP:0009800)2.71481922
34Lipid accumulation in hepatocytes (HP:0006561)2.70098788
35Partial duplication of thumb phalanx (HP:0009944)2.67370923
36Generalized tonic-clonic seizures (HP:0002069)2.66000475
37Prostate neoplasm (HP:0100787)2.64462995
38Ectopic kidney (HP:0000086)2.64144571
39Partial duplication of the phalanx of hand (HP:0009999)2.61795352
40Febrile seizures (HP:0002373)2.60419871
41Acute encephalopathy (HP:0006846)2.58809915
42Mitochondrial inheritance (HP:0001427)2.58367268
43Meckel diverticulum (HP:0002245)2.48727102
44Abnormality of the preputium (HP:0100587)2.47980713
45Abnormality of renal resorption (HP:0011038)2.45912460
46Absent septum pellucidum (HP:0001331)2.44455991
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.44322214
48Abnormality of alanine metabolism (HP:0010916)2.42942381
49Hyperalaninemia (HP:0003348)2.42942381
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42942381
51Focal seizures (HP:0007359)2.42392257
52Aplasia involving forearm bones (HP:0009822)2.40742680
53Absent forearm bone (HP:0003953)2.40742680
54Ankle contracture (HP:0006466)2.40459138
55Abnormal respiratory motile cilium physiology (HP:0012261)2.40022853
56Concave nail (HP:0001598)2.39232912
57Pallor (HP:0000980)2.37656867
58Abnormal urine phosphate concentration (HP:0012599)2.37415550
59Osteomalacia (HP:0002749)2.37305677
60Progressive macrocephaly (HP:0004481)2.35618958
61Abnormality of proline metabolism (HP:0010907)2.35073857
62Hydroxyprolinuria (HP:0003080)2.35073857
63Hyperphosphaturia (HP:0003109)2.33677325
64Absent radius (HP:0003974)2.33541981
65Abnormal ciliary motility (HP:0012262)2.31670235
66Aplasia of the musculature (HP:0100854)2.31258654
67Increased intramyocellular lipid droplets (HP:0012240)2.29442983
68Ulnar claw (HP:0001178)2.28493994
69Mesomelia (HP:0003027)2.27674444
70Vascular calcification (HP:0004934)2.27037864
71Absent thumb (HP:0009777)2.26764566
72Abnormality of the ileum (HP:0001549)2.25207491
73Spinal cord compression (HP:0002176)2.22493100
74Anomalous pulmonary venous return (HP:0010772)2.18602963
75Distal lower limb muscle weakness (HP:0009053)2.17231619
76Cardiovascular calcification (HP:0011915)2.16970844
77Abnormality of the pulmonary veins (HP:0011718)2.16014451
78Onion bulb formation (HP:0003383)2.12581931
79Poor suck (HP:0002033)2.11616847
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09642524
81Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09642524
82Ketoacidosis (HP:0001993)2.07995036
83Bilateral microphthalmos (HP:0007633)2.06958704
84Increased muscle lipid content (HP:0009058)2.05553260
85Increased CSF lactate (HP:0002490)2.04109097
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03725194
87Renal agenesis (HP:0000104)2.03520275
88Down-sloping shoulders (HP:0200021)2.03187223
89Hyperparathyroidism (HP:0000843)2.02824271
90Hyperglycinuria (HP:0003108)2.02710665
91Protrusio acetabuli (HP:0003179)2.02520632
92Abnormal number of incisors (HP:0011064)2.02268575
93Sclerocornea (HP:0000647)2.01999350
94Attenuation of retinal blood vessels (HP:0007843)2.01533940
95Colon cancer (HP:0003003)2.00153395
96Enlarged penis (HP:0000040)1.99441713
97Pendular nystagmus (HP:0012043)1.98782994
98Abnormality of the septum pellucidum (HP:0007375)1.98704014
99Hyperventilation (HP:0002883)1.98484940
100Thin bony cortex (HP:0002753)1.98454456
101Congenital, generalized hypertrichosis (HP:0004540)1.98354688
102Turricephaly (HP:0000262)1.98220770
103Morphological abnormality of the middle ear (HP:0008609)1.97160590
104Absent eyebrow (HP:0002223)1.95904919
105Shallow orbits (HP:0000586)1.91972480
106Overfolded helix (HP:0000396)1.91350409
107Clubbing of toes (HP:0100760)1.90946225
108Renal salt wasting (HP:0000127)1.90875370
109Microglossia (HP:0000171)1.88315163
110Limb dystonia (HP:0002451)1.86979301
111Atrophic scars (HP:0001075)1.86561022
112Broad-based gait (HP:0002136)1.85976810
113Abnormality of the carotid arteries (HP:0005344)1.85092582
114Heart block (HP:0012722)1.84994793
115Horseshoe kidney (HP:0000085)1.84958844
116Mixed hearing impairment (HP:0000410)1.84417155
117Absence seizures (HP:0002121)1.84371925
118Abnormal atrioventricular conduction (HP:0005150)1.83209887
119Atrioventricular block (HP:0001678)1.81969767
120Abnormal rod and cone electroretinograms (HP:0008323)1.81394098
121Mildly elevated creatine phosphokinase (HP:0008180)1.81167682
122Cerebral edema (HP:0002181)1.80600603
123Truncus arteriosus (HP:0001660)1.79269768
124Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79253166
125Septate vagina (HP:0001153)1.77580134
126Abnormal respiratory motile cilium morphology (HP:0005938)1.77458619
127Abnormal respiratory epithelium morphology (HP:0012253)1.77458619
128Absent/shortened dynein arms (HP:0200106)1.76739282
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.76739282
130Agitation (HP:0000713)1.76584221
131Hyperthyroidism (HP:0000836)1.76041150
132Hypoplastic left heart (HP:0004383)1.75871287
133Abnormality of reticulocytes (HP:0004312)1.74539861
134Hepatocellular necrosis (HP:0001404)1.74354110
135Decreased motor nerve conduction velocity (HP:0003431)1.73804175
136Supranuclear gaze palsy (HP:0000605)1.73258695
137Chronic bronchitis (HP:0004469)1.72734274
138Hypergonadotropic hypogonadism (HP:0000815)1.71189535
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71139923
140Slender build (HP:0001533)1.70500997
141Parakeratosis (HP:0001036)1.69547965
142Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68267225
143Premature rupture of membranes (HP:0001788)1.67812223
144Rib fusion (HP:0000902)1.66875794
145J-shaped sella turcica (HP:0002680)1.66797967
146Abnormally folded helix (HP:0008544)1.66669350
147Exertional dyspnea (HP:0002875)1.66632059
148Myokymia (HP:0002411)1.66102272
149Humeroradial synostosis (HP:0003041)1.65908598
150Synostosis involving the elbow (HP:0003938)1.65908598
151Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65596306
152Seborrheic dermatitis (HP:0001051)1.65174463
153Lip pit (HP:0100267)1.64694320
154Renal dysplasia (HP:0000110)1.64110936
155Coronal craniosynostosis (HP:0004440)1.62445769
156Microretrognathia (HP:0000308)1.61737443
157Patellar dislocation (HP:0002999)1.61383256
158Congenital ichthyosiform erythroderma (HP:0007431)1.59011730
159Hypercortisolism (HP:0001578)1.58683235
160Septo-optic dysplasia (HP:0100842)1.58511791
161Cervical subluxation (HP:0003308)1.58126022
162Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.57705660
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.57660291
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.57196584
165Hypoplasia of the fovea (HP:0007750)1.57196584
166Aplasia involving bones of the upper limbs (HP:0009823)1.57104235
167Aplasia of the phalanges of the hand (HP:0009802)1.57104235
168Aplasia involving bones of the extremities (HP:0009825)1.57104235
169Hypercalcemia (HP:0003072)1.56753920
170Double outlet right ventricle (HP:0001719)1.55131593
171Congenital malformation of the right heart (HP:0011723)1.55131593
172Optic nerve hypoplasia (HP:0000609)1.53992905
173Broad hallux (HP:0010055)1.53597417
174Mitral regurgitation (HP:0001653)1.50849780
175Nasolacrimal duct obstruction (HP:0000579)1.50016052
176Polyphagia (HP:0002591)1.49262041
177Lethargy (HP:0001254)1.48401993
178Congenital glaucoma (HP:0001087)1.48097257
179Genu recurvatum (HP:0002816)1.46728038
180Long toe (HP:0010511)1.46101255
181Hypoventilation (HP:0002791)1.46055921
182Elfin facies (HP:0004428)1.45754584
183Generalized hypotonia (HP:0001290)1.45563559
184Aplasia/Hypoplasia of the breasts (HP:0010311)1.43069276
185Abnormality of cochlea (HP:0000375)1.42245700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.77911521
2INSRR3.83932708
3NME23.69256606
4STK163.68147680
5NTRK33.64373655
6GRK13.52032093
7ADRBK23.12813217
8VRK23.08745799
9SIK22.90721555
10CASK2.74191356
11BLK2.57663920
12NTRK22.34345515
13EPHA22.29098632
14MARK12.13768516
15LATS12.07621502
16PKN21.94462076
17TNIK1.93722350
18SIK11.92469564
19MUSK1.89030612
20EIF2AK21.88595616
21MAP2K21.84727750
22RPS6KB21.84329653
23DYRK31.77640255
24WNK41.75184973
25TAF11.71836026
26FES1.71253117
27WNK11.68177759
28EPHB21.67598180
29NEK61.65216656
30FGR1.54842512
31LIMK11.53329455
32MAP3K91.52977913
33NME11.50959224
34DAPK21.49914074
35SMG11.48163848
36TESK11.42116164
37EPHA41.40739392
38MAPKAPK31.38946051
39IRAK31.36235021
40TLK11.34878183
41ILK1.34597871
42PIK3CG1.28171437
43TAOK11.27376278
44LATS21.24570562
45STK391.24360464
46PRKCG1.21708844
47CLK11.17826836
48GRK51.16538374
49PHKG21.15673814
50PHKG11.15673814
51TNK21.12939915
52DDR21.11939962
53ADRBK11.10676944
54PAK61.09041540
55KSR11.07091178
56CDC42BPA1.04834447
57BUB11.04599951
58ABL21.02699118
59PDGFRA0.99310297
60AURKA0.98023734
61PRKCE0.97538050
62CAMK2G0.97072408
63MAP2K70.96112765
64WNK30.95951191
65FER0.95872536
66MAP3K40.95512167
67ZAK0.92541265
68PKN10.92322198
69SIK30.91668771
70RPS6KA20.89998016
71CHEK20.88381060
72RIPK40.87069387
73PRKCH0.85913578
74BRAF0.84958756
75PRKCI0.84925069
76CAMK2A0.82612571
77BMPR1B0.80270350
78LMTK20.78494230
79MYLK0.78432148
80PIK3CA0.78107948
81PINK10.77727928
82CAMK2D0.77489022
83CDK50.75297362
84PIM20.71708343
85CDC70.71294443
86MAPK130.70885997
87MARK20.69852879
88RPS6KA60.69471344
89FYN0.68490900
90PDK30.68009378
91PDK40.68009378
92NEK20.68004889
93MAP3K130.66607686
94DYRK1B0.66381720
95BCKDK0.65961151
96PAK20.64880059
97PAK40.64539784
98NTRK10.64300819
99PRKD30.64163511
100RPS6KC10.63848038
101RPS6KL10.63848038
102CAMK10.63433836
103SGK10.62499194
104NUAK10.60610602
105PRKCB0.59367328
106PRKG20.58976008
107DAPK30.58174053
108GRK60.57255028
109MINK10.56474705
110HCK0.55521102
111PDK10.54671097
112CAMK2B0.53921048
113STK110.53216608
114FGFR40.52572721
115CDK70.51936021
116MAPK120.51558629
117ERBB20.50768698
118PRKACA0.49482992
119TTK0.49450537
120ERBB40.48317490
121DMPK0.48164429
122PLK10.47810629
123MAPKAPK50.47311446
124IRAK20.47034753
125INSR0.46971306
126PTK60.46185665
127MAPK40.45789062
128PDPK10.45458394
129UHMK10.44576960
130PTK20.44002136
131MAP2K40.43834442
132TAOK30.43433572
133CSNK1D0.43229778
134CHUK0.43225127
135VRK10.42286087
136RIPK10.42248302
137CAMK1G0.41488452
138MARK30.41071076
139PAK30.41031873
140TYRO30.40768004
141MAP2K10.40317573
142MST1R0.39929462
143SRC0.39319625
144CDK140.39219337
145AURKB0.38743911
146MTOR0.38380996
147CAMK1D0.37739479
148DYRK20.37590274
149PLK20.36930555
150PBK0.36024953
151ROCK20.35636381
152PRKCA0.34862454
153CDK150.34498995
154CSNK1A10.34203278
155CDK11A0.34064860
156RPS6KA50.33432390
157ROCK10.33245921
158STK380.32631596
159CSNK1E0.32105253
160SGK4940.32000249
161SGK2230.32000249
162TAOK20.31638102
163HIPK20.31201666
164PRKACG0.30336964
165LYN0.30239663

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.74683217
2Oxidative phosphorylation_Homo sapiens_hsa001904.61211144
3Parkinsons disease_Homo sapiens_hsa050123.84727679
4Cardiac muscle contraction_Homo sapiens_hsa042603.05604394
5Alzheimers disease_Homo sapiens_hsa050102.99807337
6Huntingtons disease_Homo sapiens_hsa050162.82313120
7Nicotine addiction_Homo sapiens_hsa050332.75534574
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.69332527
9Phenylalanine metabolism_Homo sapiens_hsa003602.58788271
10Sulfur relay system_Homo sapiens_hsa041222.48769284
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.23924700
12beta-Alanine metabolism_Homo sapiens_hsa004102.17393570
13Morphine addiction_Homo sapiens_hsa050322.15969047
14Cocaine addiction_Homo sapiens_hsa050302.13525273
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02532587
16RNA polymerase_Homo sapiens_hsa030201.97376677
17Phototransduction_Homo sapiens_hsa047441.93637736
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92208190
19Fatty acid biosynthesis_Homo sapiens_hsa000611.92069358
20Taste transduction_Homo sapiens_hsa047421.85508235
21GABAergic synapse_Homo sapiens_hsa047271.84763571
22Glutamatergic synapse_Homo sapiens_hsa047241.84696451
23Histidine metabolism_Homo sapiens_hsa003401.82889577
24Asthma_Homo sapiens_hsa053101.72604999
25Basal cell carcinoma_Homo sapiens_hsa052171.72314663
26Amphetamine addiction_Homo sapiens_hsa050311.65567666
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64157455
28Serotonergic synapse_Homo sapiens_hsa047261.62827428
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56549002
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50182621
31Folate biosynthesis_Homo sapiens_hsa007901.46015659
32Steroid biosynthesis_Homo sapiens_hsa001001.43743097
33Linoleic acid metabolism_Homo sapiens_hsa005911.40697964
34Ether lipid metabolism_Homo sapiens_hsa005651.39141660
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38688032
36Salivary secretion_Homo sapiens_hsa049701.36853473
37Ovarian steroidogenesis_Homo sapiens_hsa049131.36238879
38Tryptophan metabolism_Homo sapiens_hsa003801.34429339
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34274985
40Tyrosine metabolism_Homo sapiens_hsa003501.33555227
41Calcium signaling pathway_Homo sapiens_hsa040201.32791547
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.30874899
43Insulin secretion_Homo sapiens_hsa049111.30701236
44Fatty acid elongation_Homo sapiens_hsa000621.30074541
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28913694
46Circadian entrainment_Homo sapiens_hsa047131.28578574
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28134986
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26571736
49Arginine and proline metabolism_Homo sapiens_hsa003301.24618216
50Olfactory transduction_Homo sapiens_hsa047401.24031312
51Gastric acid secretion_Homo sapiens_hsa049711.23505588
52Caffeine metabolism_Homo sapiens_hsa002321.18628904
53Butanoate metabolism_Homo sapiens_hsa006501.18036475
54Dopaminergic synapse_Homo sapiens_hsa047281.16116123
55ABC transporters_Homo sapiens_hsa020101.15565173
56Pyrimidine metabolism_Homo sapiens_hsa002401.14193842
57Axon guidance_Homo sapiens_hsa043601.07377490
58Proteasome_Homo sapiens_hsa030501.06012625
59Hedgehog signaling pathway_Homo sapiens_hsa043401.04822223
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.03787772
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.03494562
62Phospholipase D signaling pathway_Homo sapiens_hsa040721.03265869
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02825594
64Renin secretion_Homo sapiens_hsa049241.00401256
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98839951
66Vitamin B6 metabolism_Homo sapiens_hsa007500.96568042
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96529176
68Thyroid cancer_Homo sapiens_hsa052160.96077114
69Dorso-ventral axis formation_Homo sapiens_hsa043200.95696106
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95476836
71Propanoate metabolism_Homo sapiens_hsa006400.95141900
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94031571
73Cholinergic synapse_Homo sapiens_hsa047250.93046755
74Synaptic vesicle cycle_Homo sapiens_hsa047210.92930326
75Fatty acid metabolism_Homo sapiens_hsa012120.92582585
76Melanoma_Homo sapiens_hsa052180.92558707
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90812401
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90519851
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89200506
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88853968
81Collecting duct acid secretion_Homo sapiens_hsa049660.86851975
82Gap junction_Homo sapiens_hsa045400.86283773
83ECM-receptor interaction_Homo sapiens_hsa045120.85986538
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85285163
85Homologous recombination_Homo sapiens_hsa034400.84692699
86Vibrio cholerae infection_Homo sapiens_hsa051100.84580447
87Pyruvate metabolism_Homo sapiens_hsa006200.83910296
88Protein export_Homo sapiens_hsa030600.82013986
89cAMP signaling pathway_Homo sapiens_hsa040240.81700580
90Wnt signaling pathway_Homo sapiens_hsa043100.81564289
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79459922
92Long-term depression_Homo sapiens_hsa047300.78387404
93Nitrogen metabolism_Homo sapiens_hsa009100.77832079
94Hippo signaling pathway_Homo sapiens_hsa043900.77638374
95Estrogen signaling pathway_Homo sapiens_hsa049150.74764760
96Oxytocin signaling pathway_Homo sapiens_hsa049210.74621549
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73713375
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72026972
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71805196
100Malaria_Homo sapiens_hsa051440.71631485
101Base excision repair_Homo sapiens_hsa034100.70046148
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70019447
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68727567
104Bile secretion_Homo sapiens_hsa049760.68364859
105Long-term potentiation_Homo sapiens_hsa047200.67861656
106Selenocompound metabolism_Homo sapiens_hsa004500.67472343
107Complement and coagulation cascades_Homo sapiens_hsa046100.67115292
108Purine metabolism_Homo sapiens_hsa002300.66360865
109Dilated cardiomyopathy_Homo sapiens_hsa054140.66347718
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65497480
111Metabolic pathways_Homo sapiens_hsa011000.65464938
112Spliceosome_Homo sapiens_hsa030400.65019396
113Type II diabetes mellitus_Homo sapiens_hsa049300.63561604
114GnRH signaling pathway_Homo sapiens_hsa049120.60425773
115Melanogenesis_Homo sapiens_hsa049160.60276792
116Retinol metabolism_Homo sapiens_hsa008300.59185228
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.59058911
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58911379
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57911447
120Pancreatic secretion_Homo sapiens_hsa049720.57896002
121Nucleotide excision repair_Homo sapiens_hsa034200.57609566
122Vitamin digestion and absorption_Homo sapiens_hsa049770.57063004
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.56901149
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56589104
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55894515
126Protein digestion and absorption_Homo sapiens_hsa049740.55265597
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54481041
128Endometrial cancer_Homo sapiens_hsa052130.53589591
129DNA replication_Homo sapiens_hsa030300.53066996
130Sphingolipid metabolism_Homo sapiens_hsa006000.52875485
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52288261
132Glutathione metabolism_Homo sapiens_hsa004800.52034399
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50996931
134Inositol phosphate metabolism_Homo sapiens_hsa005620.49508569
135ErbB signaling pathway_Homo sapiens_hsa040120.49505501
136PPAR signaling pathway_Homo sapiens_hsa033200.48779246
137Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48502684
138Tight junction_Homo sapiens_hsa045300.48384936
139Staphylococcus aureus infection_Homo sapiens_hsa051500.46679048
140Ras signaling pathway_Homo sapiens_hsa040140.46480990
141Bladder cancer_Homo sapiens_hsa052190.45270770
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45149027
143Fanconi anemia pathway_Homo sapiens_hsa034600.44680438
144Chemical carcinogenesis_Homo sapiens_hsa052040.43723057
145Glucagon signaling pathway_Homo sapiens_hsa049220.43494034
146RNA transport_Homo sapiens_hsa030130.41077791
147Fatty acid degradation_Homo sapiens_hsa000710.39910078
148TGF-beta signaling pathway_Homo sapiens_hsa043500.39514660
149Arachidonic acid metabolism_Homo sapiens_hsa005900.39340674
150Notch signaling pathway_Homo sapiens_hsa043300.37905889
151AMPK signaling pathway_Homo sapiens_hsa041520.37247563
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32429943
153Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29738737
154N-Glycan biosynthesis_Homo sapiens_hsa005100.29624400
155Mismatch repair_Homo sapiens_hsa034300.29218834
156Alcoholism_Homo sapiens_hsa050340.28969264
157Renal cell carcinoma_Homo sapiens_hsa052110.28404171
158Galactose metabolism_Homo sapiens_hsa000520.27869018
159RNA degradation_Homo sapiens_hsa030180.27557318

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »