KCNK16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)7.22008013
2peptide hormone processing (GO:0016486)7.21877717
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.13580849
4COPII vesicle coating (GO:0048208)6.87468485
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.71366289
6protein retention in ER lumen (GO:0006621)6.41418383
7positive regulation of insulin secretion (GO:0032024)6.21405903
8lactate metabolic process (GO:0006089)6.20005168
9protein maturation by protein folding (GO:0022417)6.14838082
10negative regulation of gluconeogenesis (GO:0045721)6.03741733
11regulation of type B pancreatic cell apoptotic process (GO:2000674)6.01779620
12glandular epithelial cell differentiation (GO:0002067)5.71836533
13signal peptide processing (GO:0006465)5.65482823
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.52132831
15sequestering of metal ion (GO:0051238)5.34521789
16cellular ketone body metabolic process (GO:0046950)5.30336369
17positive regulation of peptide hormone secretion (GO:0090277)5.08056305
18positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003575.07318097
19exocrine pancreas development (GO:0031017)4.93060121
20L-alpha-amino acid transmembrane transport (GO:1902475)4.92657617
21vesicle coating (GO:0006901)4.92395346
22positive regulation of peptide secretion (GO:0002793)4.90416966
23response to dietary excess (GO:0002021)4.89565721
24regulation of insulin secretion (GO:0050796)4.81255323
25insulin secretion (GO:0030073)4.76922460
26activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.75794876
27negative regulation of protein oligomerization (GO:0032460)4.69057188
28ketone body metabolic process (GO:1902224)4.67768179
29toxin metabolic process (GO:0009404)4.54780369
30negative regulation of hormone biosynthetic process (GO:0032353)4.54085361
31positive regulation of nuclease activity (GO:0032075)4.52300485
32negative regulation of glycoprotein biosynthetic process (GO:0010561)4.43011633
33regulation of peptide hormone secretion (GO:0090276)4.40533725
34negative regulation of cytosolic calcium ion concentration (GO:0051481)4.35300888
35fatty acid homeostasis (GO:0055089)4.33559043
36glandular epithelial cell development (GO:0002068)4.33413204
37nitric oxide mediated signal transduction (GO:0007263)4.33125161
38regulation of peptide secretion (GO:0002791)4.32311450
39epithelial cell fate commitment (GO:0072148)4.15240487
40ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.14564776
41regulation of nuclease activity (GO:0032069)4.13811853
42inositol phosphate catabolic process (GO:0071545)4.10207434
43positive regulation of respiratory burst (GO:0060267)4.00512316
44inositol phosphate dephosphorylation (GO:0046855)3.99799994
45phosphorylated carbohydrate dephosphorylation (GO:0046838)3.99799994
46type B pancreatic cell development (GO:0003323)3.98929132
47positive regulation of hormone secretion (GO:0046887)3.96517480
48regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.95660965
49negative regulation of hormone metabolic process (GO:0032351)3.94768564
50endoplasmic reticulum unfolded protein response (GO:0030968)3.94424556
51chemosensory behavior (GO:0007635)3.88965675
52positive regulation of glycogen biosynthetic process (GO:0045725)3.87117707
53cellular response to unfolded protein (GO:0034620)3.86681394
54cellular response to topologically incorrect protein (GO:0035967)3.85900900
55peptide hormone secretion (GO:0030072)3.85159351
56cellular response to vitamin D (GO:0071305)3.85057277
57regulation of hormone secretion (GO:0046883)3.84089988
58negative regulation of acute inflammatory response (GO:0002674)3.78758797
59positive regulation of vesicle fusion (GO:0031340)3.78230754
60protein autoprocessing (GO:0016540)3.76554206
61peptide secretion (GO:0002790)3.74240128
62ER to Golgi vesicle-mediated transport (GO:0006888)3.70424716
63cellular zinc ion homeostasis (GO:0006882)3.70301487
64astrocyte differentiation (GO:0048708)3.69401911
65intra-Golgi vesicle-mediated transport (GO:0006891)3.66168621
66positive regulation of macroautophagy (GO:0016239)3.64604767
67ER-nucleus signaling pathway (GO:0006984)3.64338000
68macroautophagy (GO:0016236)3.64178205
69detection of calcium ion (GO:0005513)3.63694646
70signal transduction involved in regulation of gene expression (GO:0023019)3.59430500
71regulation of peptide transport (GO:0090087)3.55419241
72ER overload response (GO:0006983)3.53482353
73negative regulation of insulin secretion (GO:0046676)3.52061512
74GDP-mannose metabolic process (GO:0019673)3.51419862
75protein N-linked glycosylation via asparagine (GO:0018279)3.50836928
76regulation of energy homeostasis (GO:2000505)3.48902972
77peptidyl-asparagine modification (GO:0018196)3.48463768
78cellular response to glucagon stimulus (GO:0071377)3.48407005
79negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.46054234
80growth hormone secretion (GO:0030252)3.44989171
81regulation of glycolytic process (GO:0006110)3.44840819
82negative regulation of glycoprotein metabolic process (GO:1903019)3.43917923
83negative regulation of glycogen metabolic process (GO:0070874)3.42081574
84positive regulation of protein autophosphorylation (GO:0031954)3.41322325
85positive regulation of glycolytic process (GO:0045821)3.40881691
86glycine transport (GO:0015816)3.37638254
87zinc ion homeostasis (GO:0055069)3.33004672
88columnar/cuboidal epithelial cell development (GO:0002066)3.30562459
89protein localization to Golgi apparatus (GO:0034067)3.30440707
90regulation of protein glycosylation (GO:0060049)3.30428688
91positive regulation of glycogen metabolic process (GO:0070875)3.30386445
92response to endoplasmic reticulum stress (GO:0034976)3.28122101
93hormone secretion (GO:0046879)3.25451573
94nodal signaling pathway (GO:0038092)3.25215409
95protein N-linked glycosylation (GO:0006487)3.19442405
96peptide metabolic process (GO:0006518)3.19331100
97response to hexose (GO:0009746)3.18870786
98negative regulation of JUN kinase activity (GO:0043508)3.18296350
99positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14089507
100negative regulation of execution phase of apoptosis (GO:1900118)3.13699867
101polyol catabolic process (GO:0046174)3.12585189
102water-soluble vitamin biosynthetic process (GO:0042364)3.12339124
103negative regulation of catecholamine secretion (GO:0033604)3.10216338
104response to glucose (GO:0009749)3.09967886
105positive regulation of amino acid transport (GO:0051957)3.08502801
106peptide transport (GO:0015833)3.08178842
107carbohydrate homeostasis (GO:0033500)3.08015798
108glucose homeostasis (GO:0042593)3.08015798
109negative regulation of peptide hormone secretion (GO:0090278)3.06488200
110hormone transport (GO:0009914)3.06076755
111regulation of hexokinase activity (GO:1903299)3.05234237
112regulation of glucokinase activity (GO:0033131)3.05234237
113toxin transport (GO:1901998)3.04712597
114calcium ion import (GO:0070509)3.04703678
115auditory receptor cell differentiation (GO:0042491)3.03877604
116response to unfolded protein (GO:0006986)3.03675912
117dentate gyrus development (GO:0021542)3.03581367
118response to monosaccharide (GO:0034284)3.03155041
119response to topologically incorrect protein (GO:0035966)3.01612453
120regulation of gluconeogenesis (GO:0006111)3.01611118
121positive regulation of response to nutrient levels (GO:0032109)3.01164673
122positive regulation of response to extracellular stimulus (GO:0032106)3.01164673
123neuron fate specification (GO:0048665)3.01089923
124response to hepatocyte growth factor (GO:0035728)3.00291651
125cellular response to hepatocyte growth factor stimulus (GO:0035729)3.00291651
126regulation of glucocorticoid secretion (GO:2000849)2.99023382
127glycerophospholipid catabolic process (GO:0046475)2.98599644
128dendritic spine morphogenesis (GO:0060997)2.97768743
129cellular response to leptin stimulus (GO:0044320)2.97363048
130cellular response to hexose stimulus (GO:0071331)2.96809335
131Golgi vesicle transport (GO:0048193)2.95605232
132negative regulation of peptide secretion (GO:0002792)2.95522893
133kidney morphogenesis (GO:0060993)2.93226290
134Golgi organization (GO:0007030)2.91388966
135positive regulation of glucose metabolic process (GO:0010907)2.91256612
136regulation of autophagic vacuole assembly (GO:2000785)2.90735843
137regulation of oxidative phosphorylation (GO:0002082)2.88853191
138positive regulation of gluconeogenesis (GO:0045722)2.87415111
139positive regulation of nitric-oxide synthase activity (GO:0051000)2.86559947
140negative regulation of neurological system process (GO:0031645)2.86524825
141xenobiotic catabolic process (GO:0042178)2.83784879
142respiratory chain complex IV assembly (GO:0008535)2.80933282
143zinc ion transmembrane transport (GO:0071577)2.80165616
144phenylpropanoid metabolic process (GO:0009698)2.79687922
145L-phenylalanine catabolic process (GO:0006559)2.78608617
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.78608617
147regulation of vacuole organization (GO:0044088)2.76829808
148protein targeting to Golgi (GO:0000042)2.76641821
149regulation of calcium ion-dependent exocytosis (GO:0017158)2.72940373
150amide transport (GO:0042886)2.72857362
151succinate metabolic process (GO:0006105)2.71205128
152regulation of cellular carbohydrate catabolic process (GO:0043471)2.68913483
153regulation of carbohydrate catabolic process (GO:0043470)2.68913483
154establishment of protein localization to Golgi (GO:0072600)2.68760527
155positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.68695961
156somite rostral/caudal axis specification (GO:0032525)2.67122123
157positive regulation of meiosis (GO:0045836)2.63673089
158response to leptin (GO:0044321)2.62712605
159COPI coating of Golgi vesicle (GO:0048205)11.2578903
160Golgi transport vesicle coating (GO:0048200)11.2578903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.61870457
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.44126587
3GATA1_22025678_ChIP-Seq_K562_Human3.47103434
4GBX2_23144817_ChIP-Seq_PC3_Human2.73491400
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44588013
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.38228331
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30482287
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21163183
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20695690
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.20307296
11PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.02416419
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.9397677
13OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.96002860
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94071206
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92658908
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87752551
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83636977
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.81233559
19CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77306644
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75434252
21SMAD4_21799915_ChIP-Seq_A2780_Human1.74205608
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.74030679
23IGF1R_20145208_ChIP-Seq_DFB_Human1.70259288
24HTT_18923047_ChIP-ChIP_STHdh_Human1.70150360
25NR3C1_23031785_ChIP-Seq_PC12_Mouse1.69808503
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.69478405
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68981236
28REST_19997604_ChIP-ChIP_NEURONS_Mouse1.68367787
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65854221
30BCAT_22108803_ChIP-Seq_LS180_Human1.65040783
31SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.64180198
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62099398
33FUS_26573619_Chip-Seq_HEK293_Human1.55423256
34VDR_22108803_ChIP-Seq_LS180_Human1.54846616
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.54837482
36P300_19829295_ChIP-Seq_ESCs_Human1.54455917
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53968129
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50644644
39TFEB_21752829_ChIP-Seq_HELA_Human1.50410553
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49508690
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.49055638
42FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.47223413
43AR_25329375_ChIP-Seq_VCAP_Human1.47002992
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46875290
45CLOCK_20551151_ChIP-Seq_293T_Human1.45442156
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.42110600
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42065971
48STAT3_23295773_ChIP-Seq_U87_Human1.41444014
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40728669
50FOXA1_25552417_ChIP-Seq_VCAP_Human1.40228735
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39010063
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.38583603
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37920203
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37561824
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35672670
56CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35290990
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.34624506
58ER_23166858_ChIP-Seq_MCF-7_Human1.33292069
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31889921
60P53_22387025_ChIP-Seq_ESCs_Mouse1.31743035
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31609965
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30928679
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30604981
64TAF15_26573619_Chip-Seq_HEK293_Human1.30432619
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30277352
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29617700
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.29330734
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.28447339
69CDX2_22108803_ChIP-Seq_LS180_Human1.27551079
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26734594
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.25886409
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.25208825
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24153693
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23482639
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23272205
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22799912
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.22450067
78GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.22447398
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22109147
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22067424
81* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21791073
82* FOXA1_25329375_ChIP-Seq_VCAP_Human1.21791073
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.21677442
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19703327
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.19348168
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18623425
87TCF4_23295773_ChIP-Seq_U87_Human1.18464704
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17834968
89CTCF_18555785_Chip-Seq_ESCs_Mouse1.17631418
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17332611
91* CBP_20019798_ChIP-Seq_JUKART_Human1.17142568
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17142568
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.16256823
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15788822
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15101727
96REST_21632747_ChIP-Seq_MESCs_Mouse1.14762653
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14310767
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13605428
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13414379
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13249047
101NMYC_18555785_Chip-Seq_ESCs_Mouse1.12853190
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.12779680
103TP53_22573176_ChIP-Seq_HFKS_Human1.12614326
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12571020
105P300_18555785_Chip-Seq_ESCs_Mouse1.11542566
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08552017
107* LXR_22158963_ChIP-Seq_LIVER_Mouse1.08237527
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08151224
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07076074
110TCF4_22108803_ChIP-Seq_LS180_Human1.06847514
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.06123568
112EWS_26573619_Chip-Seq_HEK293_Human1.05932425
113TBL1_22424771_ChIP-Seq_293T_Human1.05786228
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04767342
115* NANOG_19829295_ChIP-Seq_ESCs_Human1.04500861
116* SOX2_19829295_ChIP-Seq_ESCs_Human1.04500861
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.04468434
118PU1_27457419_Chip-Seq_LIVER_Mouse1.03470851
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03365250
120* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03202799
121ZNF274_21170338_ChIP-Seq_K562_Hela1.02747605
122GABP_19822575_ChIP-Seq_HepG2_Human1.01926930
123* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01685569
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01533301
125ZFX_18555785_Chip-Seq_ESCs_Mouse1.01355967
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.01229023
127ERG_20517297_ChIP-Seq_VCAP_Human1.01126668
128OCT4_18555785_Chip-Seq_ESCs_Mouse1.00775761
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99645974
130KLF4_18555785_Chip-Seq_ESCs_Mouse0.99460178
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99443633
132* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99239127
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98788841
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98630178
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97974694
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97771224
137PHF8_20622853_ChIP-Seq_HELA_Human0.97626099
138PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97097754
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97071724
140E2F1_17053090_ChIP-ChIP_MCF-7_Human0.95271264
141CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94414616
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93786416
143SOX2_20726797_ChIP-Seq_SW620_Human0.93406886
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92894457
145GATA1_19941826_ChIP-Seq_K562_Human0.92298086
146ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88545264
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88347116
148CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88091864
149MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86677520
150TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85139615
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85111913
152SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84401413
153DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83693655
154ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83640799
155FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83389443
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83299533
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83148165
158LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81676765
159AR_20517297_ChIP-Seq_VCAP_Human0.81441752
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81392410
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81316276
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.81242770
163CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80788796
164SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80354678
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79737353
166DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79687868
167CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79417063
168GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79323869
169RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78841210
170RARB_24833708_ChIP-Seq_LIVER_Mouse0.78325064
171GATA3_27048872_Chip-Seq_THYMUS_Human0.78207496
172TET1_21451524_ChIP-Seq_MESCs_Mouse0.77617646
173BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77353362
174IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76858596
175TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75589305
176GATA4_25053715_ChIP-Seq_YYC3_Human0.73786496
177PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73254125
178CTCF_20526341_ChIP-Seq_ESCs_Human0.71606933
179PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71220919
180NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71147867
181CHD1_26751641_Chip-Seq_LNCaP_Human0.70889288
182YY1_22570637_ChIP-Seq_MALME-3M_Human0.70684036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.58351782
2MP0003183_abnormal_peptide_metabolism4.49687846
3MP0003195_calcinosis4.35860231
4MP0003283_abnormal_digestive_organ4.33039898
5MP0002877_abnormal_melanocyte_morpholog4.07223537
6MP0002909_abnormal_adrenal_gland3.99761597
7MP0004043_abnormal_pH_regulation3.90374568
8MP0005379_endocrine/exocrine_gland_phen3.83391036
9MP0002693_abnormal_pancreas_physiology3.81139488
10MP0001944_abnormal_pancreas_morphology3.76506252
11MP0010234_abnormal_vibrissa_follicle3.45310366
12MP0009780_abnormal_chondrocyte_physiolo3.24573783
13MP0005220_abnormal_exocrine_pancreas3.20972464
14MP0002837_dystrophic_cardiac_calcinosis3.04753940
15MP0005645_abnormal_hypothalamus_physiol2.99081428
16MP0000003_abnormal_adipose_tissue2.94273338
17MP0010386_abnormal_urinary_bladder2.89317858
18MP0000678_abnormal_parathyroid_gland2.80955491
19MP0008877_abnormal_DNA_methylation2.79634603
20MP0003122_maternal_imprinting2.54737366
21MP0002078_abnormal_glucose_homeostasis2.30394351
22MP0006072_abnormal_retinal_apoptosis2.28009034
23MP0004264_abnormal_extraembryonic_tissu1.98715435
24MP0002638_abnormal_pupillary_reflex1.96298272
25MP0009046_muscle_twitch1.78002692
26MP0002928_abnormal_bile_duct1.77323927
27MP0002163_abnormal_gland_morphology1.68406452
28MP0001986_abnormal_taste_sensitivity1.68256743
29MP0001765_abnormal_ion_homeostasis1.62513562
30MP0001756_abnormal_urination1.60705197
31MP0008961_abnormal_basal_metabolism1.60149464
32MP0005084_abnormal_gallbladder_morpholo1.58176988
33MP0005257_abnormal_intraocular_pressure1.57289203
34MP0005365_abnormal_bile_salt1.54939246
35MP0000462_abnormal_digestive_system1.54564523
36MP0004885_abnormal_endolymph1.54166130
37MP0010329_abnormal_lipoprotein_level1.52168752
38MP0004270_analgesia1.51850722
39MP0002138_abnormal_hepatobiliary_system1.48812373
40MP0003959_abnormal_lean_body1.45123540
41MP0005646_abnormal_pituitary_gland1.38574176
42MP0002234_abnormal_pharynx_morphology1.37745691
43MP0009643_abnormal_urine_homeostasis1.37624026
44MP0003953_abnormal_hormone_level1.37345791
45MP0000613_abnormal_salivary_gland1.34638489
46MP0005058_abnormal_lysosome_morphology1.28123138
47MP0002938_white_spotting1.28054442
48MP0003172_abnormal_lysosome_physiology1.27019128
49MP0002896_abnormal_bone_mineralization1.26684260
50MP0005375_adipose_tissue_phenotype1.24283637
51MP0006054_spinal_hemorrhage1.22492752
52MP0001502_abnormal_circadian_rhythm1.20104724
53MP0005636_abnormal_mineral_homeostasis1.18581980
54MP0003300_gastrointestinal_ulcer1.18261158
55MP0006292_abnormal_olfactory_placode1.13715492
56MP0002272_abnormal_nervous_system1.12197786
57MP0002822_catalepsy1.12102988
58MP0003123_paternal_imprinting1.11504943
59MP0003633_abnormal_nervous_system1.08800089
60MP0009745_abnormal_behavioral_response1.07596822
61MP0004510_myositis1.06331389
62MP0002064_seizures1.05336772
63MP0005075_abnormal_melanosome_morpholog1.03765149
64MP0003119_abnormal_digestive_system1.03611493
65MP0005551_abnormal_eye_electrophysiolog1.01951394
66MP0000631_abnormal_neuroendocrine_gland1.01787921
67MP0002295_abnormal_pulmonary_circulatio0.99741259
68MP0002557_abnormal_social/conspecific_i0.99633668
69MP0002090_abnormal_vision0.98987364
70MP0003252_abnormal_bile_duct0.98755401
71MP0001984_abnormal_olfaction0.98253490
72MP0004134_abnormal_chest_morphology0.97090973
73MP0000427_abnormal_hair_cycle0.92706352
74MP0003787_abnormal_imprinting0.92657023
75MP0003121_genomic_imprinting0.90937469
76MP0000639_abnormal_adrenal_gland0.90035285
77MP0005448_abnormal_energy_balance0.89964973
78MP0002751_abnormal_autonomic_nervous0.89544318
79MP0001764_abnormal_homeostasis0.88760243
80MP0004924_abnormal_behavior0.86844904
81MP0005386_behavior/neurological_phenoty0.86844904
82MP0004233_abnormal_muscle_weight0.84961016
83MP0001905_abnormal_dopamine_level0.84836881
84MP0001270_distended_abdomen0.83747502
85MP0005535_abnormal_body_temperature0.83380847
86MP0000230_abnormal_systemic_arterial0.82644522
87MP0010678_abnormal_skin_adnexa0.82409792
88MP0002572_abnormal_emotion/affect_behav0.81412767
89MP0002139_abnormal_hepatobiliary_system0.80846255
90MP0005253_abnormal_eye_physiology0.79012827
91MP0003890_abnormal_embryonic-extraembry0.78565428
92MP0002160_abnormal_reproductive_system0.77785321
93MP0000516_abnormal_urinary_system0.77478434
94MP0005367_renal/urinary_system_phenotyp0.77478434
95MP0001501_abnormal_sleep_pattern0.75575742
96MP0002733_abnormal_thermal_nociception0.73565186
97MP0005408_hypopigmentation0.73553383
98MP0003879_abnormal_hair_cell0.73496709
99MP0002229_neurodegeneration0.73495887
100MP0005389_reproductive_system_phenotype0.72681571
101MP0001970_abnormal_pain_threshold0.72590016
102MP0005310_abnormal_salivary_gland0.71681597
103MP0001727_abnormal_embryo_implantation0.71031391
104MP0005174_abnormal_tail_pigmentation0.70352805
105MP0004133_heterotaxia0.70299623
106MP0003868_abnormal_feces_composition0.68241566
107MP0009672_abnormal_birth_weight0.67348999
108MP0010352_gastrointestinal_tract_polyps0.64547165
109MP0005452_abnormal_adipose_tissue0.64163699
110MP0004085_abnormal_heartbeat0.62045764
111MP0004215_abnormal_myocardial_fiber0.61004829
112MP0002269_muscular_atrophy0.60948214
113MP0002876_abnormal_thyroid_physiology0.60297220
114MP0001661_extended_life_span0.59927743
115MP0002970_abnormal_white_adipose0.58468567
116MP0002118_abnormal_lipid_homeostasis0.57632229
117MP0001299_abnormal_eye_distance/0.57369322
118MP0009642_abnormal_blood_homeostasis0.55694679
119MP0002069_abnormal_eating/drinking_beha0.55086795
120MP0000538_abnormal_urinary_bladder0.54853603
121MP0003866_abnormal_defecation0.54661021
122MP0002653_abnormal_ependyma_morphology0.54605737
123MP0002734_abnormal_mechanical_nocicepti0.54492806
124MP0004019_abnormal_vitamin_homeostasis0.51540888
125MP0009703_decreased_birth_body0.50992789
126MP0005334_abnormal_fat_pad0.50872014
127MP0001666_abnormal_nutrient_absorption0.49403818
128MP0000681_abnormal_thyroid_gland0.48153633
129MP0005332_abnormal_amino_acid0.47772326
130MP0002177_abnormal_outer_ear0.47046896
131MP0004145_abnormal_muscle_electrophysio0.46236783
132MP0003045_fibrosis0.45518576
133MP0003795_abnormal_bone_structure0.45489911
134MP0000955_abnormal_spinal_cord0.45082537
135MP0005670_abnormal_white_adipose0.44857016
136MP0002971_abnormal_brown_adipose0.43514351
137MP0005083_abnormal_biliary_tract0.42656158
138MP0006036_abnormal_mitochondrial_physio0.42246505

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.55539140
2Hypoglycemic seizures (HP:0002173)8.14354474
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.52622605
4Hypoglycemic coma (HP:0001325)7.45057967
5Symptomatic seizures (HP:0011145)7.18857804
6Hyperglycemia (HP:0003074)5.60691223
7Late onset (HP:0003584)5.38055311
8Abnormality of endocrine pancreas physiology (HP:0012093)5.37040252
9Abnormality of the pancreatic islet cells (HP:0006476)5.37040252
10Ketoacidosis (HP:0001993)5.33436966
11Abnormality of calcium-phosphate metabolism (HP:0100530)5.30438140
12Pancreatic islet-cell hyperplasia (HP:0004510)5.02640739
13Insulin-resistant diabetes mellitus (HP:0000831)4.87081789
14Large for gestational age (HP:0001520)4.56228863
15Retinal atrophy (HP:0001105)4.26712437
16Hypomagnesemia (HP:0002917)3.86014883
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.61776459
18Agitation (HP:0000713)3.56548234
19Abnormal pancreas size (HP:0012094)3.50119233
20Insulin resistance (HP:0000855)3.42834415
21Dysostosis multiplex (HP:0000943)3.34994407
22Enlarged penis (HP:0000040)3.34894829
23Decreased circulating renin level (HP:0003351)3.32031132
24Ketosis (HP:0001946)3.25769370
25Hyperparathyroidism (HP:0000843)3.24579815
26Generalized aminoaciduria (HP:0002909)3.21307343
27Mucopolysacchariduria (HP:0008155)3.16533248
28Urinary glycosaminoglycan excretion (HP:0003541)3.16533248
29Dysautonomia (HP:0002459)3.02546278
30Prominent metopic ridge (HP:0005487)3.02196282
31Abnormality of magnesium homeostasis (HP:0004921)3.00696523
32Hypokalemia (HP:0002900)2.92875770
33Abnormality of polysaccharide metabolism (HP:0011012)2.88779914
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88779914
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88779914
36Pheochromocytoma (HP:0002666)2.88064496
37Menstrual irregularities (HP:0000858)2.83801042
38Osteomalacia (HP:0002749)2.75713808
39Gout (HP:0001997)2.64932201
40Neuroendocrine neoplasm (HP:0100634)2.60320754
41Abnormality of the metopic suture (HP:0005556)2.54372025
42Progressive neurologic deterioration (HP:0002344)2.53874015
43Congenital malformation of the right heart (HP:0011723)2.48702538
44Double outlet right ventricle (HP:0001719)2.48702538
45Xanthomatosis (HP:0000991)2.47786932
46Growth hormone excess (HP:0000845)2.45216231
47Hyperthyroidism (HP:0000836)2.44958587
48Hypercortisolism (HP:0001578)2.41414768
49Hyperkalemia (HP:0002153)2.40554743
50Abnormality of potassium homeostasis (HP:0011042)2.38754173
51Abnormality of renin-angiotensin system (HP:0000847)2.38728571
52Thoracolumbar scoliosis (HP:0002944)2.38120749
53Abnormal drinking behavior (HP:0030082)2.37857376
54Polydipsia (HP:0001959)2.37857376
55Hepatic necrosis (HP:0002605)2.37085681
56Hypoplasia of the fovea (HP:0007750)2.37037180
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.37037180
58EEG with generalized epileptiform discharges (HP:0011198)2.34699034
59Muscular hypotonia of the trunk (HP:0008936)2.34289037
60Hypsarrhythmia (HP:0002521)2.33401915
61Limb hypertonia (HP:0002509)2.33322102
62Abnormality of the fovea (HP:0000493)2.31288121
63Neoplasm of the adrenal cortex (HP:0100641)2.30170784
64Downturned corners of mouth (HP:0002714)2.29417719
65Orthostatic hypotension (HP:0001278)2.25256144
66Abdominal distention (HP:0003270)2.25085771
67Hypotension (HP:0002615)2.23984836
68Epileptiform EEG discharges (HP:0011182)2.23324032
69Hyperphosphatemia (HP:0002905)2.23156329
70Hemiparesis (HP:0001269)2.22440483
71Restlessness (HP:0000711)2.19979083
72Hyperactive renin-angiotensin system (HP:0000841)2.19736555
73Abnormality of the intrinsic pathway (HP:0010989)2.15407046
74Type I diabetes mellitus (HP:0100651)2.14832748
75Chronic bronchitis (HP:0004469)2.09492716
76Conjugated hyperbilirubinemia (HP:0002908)2.08466431
77Hypophosphatemia (HP:0002148)2.05345086
78Abnormality of chloride homeostasis (HP:0011422)2.05299830
79Abnormality of the renal cortex (HP:0011035)2.04884771
80Vacuolated lymphocytes (HP:0001922)2.04052121
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03886845
82Abnormal protein glycosylation (HP:0012346)2.01843658
83Abnormal glycosylation (HP:0012345)2.01843658
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01843658
85Abnormal protein N-linked glycosylation (HP:0012347)2.01843658
86Hamartoma of the eye (HP:0010568)2.00167680
87Hypothermia (HP:0002045)1.98591114
88Hematochezia (HP:0002573)1.98433308
89Adrenal overactivity (HP:0002717)1.95733616
90Congenital glaucoma (HP:0001087)1.94564667
91Type II lissencephaly (HP:0007260)1.92571249
92Hepatoblastoma (HP:0002884)1.92435445
93Exocrine pancreatic insufficiency (HP:0001738)1.92206838
94Increased circulating renin level (HP:0000848)1.90106311
95Conjunctival hamartoma (HP:0100780)1.87827311
96Tongue fasciculations (HP:0001308)1.86262459
97Unilateral renal agenesis (HP:0000122)1.84733112
98Abnormal sex determination (HP:0012244)1.83369245
99Sex reversal (HP:0012245)1.83369245
100Hyperphosphaturia (HP:0003109)1.82415252
101Proximal tubulopathy (HP:0000114)1.81126828
102Intestinal atresia (HP:0011100)1.80603731
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79940091
104Generalized hyperpigmentation (HP:0007440)1.79132075
105Abnormality of glycolipid metabolism (HP:0010969)1.78901491
106Abnormality of liposaccharide metabolism (HP:0010968)1.78901491
107Abnormality of glycosphingolipid metabolism (HP:0004343)1.78901491
108Long toe (HP:0010511)1.78014379
109Protuberant abdomen (HP:0001538)1.77399501
110Progressive macrocephaly (HP:0004481)1.76507437
111Type I transferrin isoform profile (HP:0003642)1.76469704
112Myoglobinuria (HP:0002913)1.75342268
113Abnormality of vitamin B metabolism (HP:0004340)1.73958288
114Gaze-evoked nystagmus (HP:0000640)1.73117341
115Postural tremor (HP:0002174)1.72165603
116Testicular neoplasm (HP:0010788)1.72079910
117Anxiety (HP:0000739)1.70773716
118Neoplasm of the heart (HP:0100544)1.70698537
119Hypokinesia (HP:0002375)1.70654187
120Increased CSF protein (HP:0002922)1.70508031
121Prolonged partial thromboplastin time (HP:0003645)1.70497650
122Irritability (HP:0000737)1.70478863
123Nuclear cataract (HP:0100018)1.70436264
124Cortical visual impairment (HP:0100704)1.68974665
125Nephronophthisis (HP:0000090)1.68960871
126Renal cortical cysts (HP:0000803)1.67418638
127Visual hallucinations (HP:0002367)1.66847293
128Enlarged kidneys (HP:0000105)1.65852819
129Type II diabetes mellitus (HP:0005978)1.65127096
130Abnormal autonomic nervous system physiology (HP:0012332)1.64509742
131Missing ribs (HP:0000921)1.64383221
132Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64175043
133Dicarboxylic aciduria (HP:0003215)1.64175043
134Tetany (HP:0001281)1.63552764
135Macroorchidism (HP:0000053)1.62910914
136Abnormality of urine glucose concentration (HP:0011016)1.62836613
137Glycosuria (HP:0003076)1.62836613
138Pancreatic cysts (HP:0001737)1.61850596
139Polyuria (HP:0000103)1.61698361
140Abnormality of abdominal situs (HP:0011620)1.56815291
141Abdominal situs inversus (HP:0003363)1.56815291
142Congenital sensorineural hearing impairment (HP:0008527)1.56631330
143Abnormality of vitamin metabolism (HP:0100508)1.56493115
144Small for gestational age (HP:0001518)1.55940080
145Aqueductal stenosis (HP:0002410)1.55751705
146Neoplasm of the adrenal gland (HP:0100631)1.55208743
147Muscle fibrillation (HP:0010546)1.51746854
148Methylmalonic acidemia (HP:0002912)1.50117932
149Poor suck (HP:0002033)1.48913520
150Tachypnea (HP:0002789)1.48160876
151Abnormality of midbrain morphology (HP:0002418)1.48031457
152Molar tooth sign on MRI (HP:0002419)1.48031457
153Tubular atrophy (HP:0000092)1.47758384
154Urethral obstruction (HP:0000796)1.46987574
155Dialeptic seizures (HP:0011146)1.46166175
156Medial flaring of the eyebrow (HP:0010747)1.45760710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.85594711
2WNK36.60906537
3INSRR6.14449142
4PASK4.82280999
5FGFR24.15140288
6WNK42.99265027
7PIK3CG2.90154331
8DAPK22.79534321
9ERN12.74868204
10HIPK22.56537057
11PHKG12.25102934
12PHKG22.25102934
13FGFR32.14581075
14FLT32.13530813
15MAP3K22.10309219
16MAP2K62.05653840
17TAOK32.02240452
18UHMK12.01070103
19PRKD31.93397868
20MAP4K21.84277571
21NTRK11.77458548
22FRK1.75669448
23MST41.74919833
24GRK11.64035332
25STK31.59743997
26DYRK1B1.59739512
27EPHA31.57127292
28TRPM71.55348682
29CASK1.52565927
30ACVR1B1.41693944
31TNIK1.41638203
32MAP3K41.37360113
33SCYL21.31087301
34PINK11.30808417
35STK38L1.29796766
36STK161.29133406
37CSNK1G11.26475067
38PTK21.24604600
39CAMKK21.20484889
40MAP3K11.18351975
41STK241.12692171
42PAK31.12201442
43TAOK11.05991988
44MAP3K91.04114190
45PDGFRA1.04051370
46EPHA20.99772516
47PTK2B0.98934596
48MET0.94058570
49MAP2K20.93006715
50BRSK20.92015149
51WNK10.91789310
52PRKAA20.89573903
53CDC42BPA0.87219576
54ERBB30.86707146
55CSNK1G30.84757284
56EIF2AK30.82546013
57BRAF0.82123303
58IRAK10.81989286
59OXSR10.80879788
60PTK60.80134693
61PRKD20.77851210
62STK110.77349486
63TRIB30.77187037
64YES10.76555985
65BCKDK0.75882690
66CSNK1G20.74877348
67FER0.73199263
68TESK10.71821849
69DYRK30.71268177
70PNCK0.71112995
71PRKCH0.67883814
72NTRK30.66691057
73FGFR40.65460930
74ZAK0.65303674
75TNK20.63946971
76CSK0.63929377
77MAP3K120.62763250
78STK390.57931794
79IRAK40.54980792
80SIK10.53494131
81STK380.53262304
82SGK20.52942402
83ITK0.52419604
84KSR20.51758390
85STK40.51557864
86PLK30.49530936
87BRSK10.49242353
88PRKCI0.49167212
89BRD40.48119882
90EPHB10.47788570
91MAP2K70.44935283
92LIMK10.43145335
93PRKCE0.42687797
94PLK20.42101734
95SGK10.41396531
96CAMK2D0.40666966
97PRKG10.40361189
98BCR0.40234075
99DYRK1A0.39647469
100MAPKAPK30.39641719
101CSNK1A1L0.38627472
102SGK2230.38520673
103SGK4940.38520673
104ARAF0.37023383
105NLK0.36957095
106CAMK2A0.36914011
107PRKCZ0.36444782
108ROCK10.36111142
109SGK30.35973762
110MAP3K30.35956535
111ZAP700.35799069
112MAP3K70.35432211
113MTOR0.34476427
114CAMK1G0.33449365
115EIF2AK10.31967320
116BMPR1B0.29254929
117JAK20.28515053
118TRIM280.28388111
119ADRBK10.28034049
120RET0.27768142
121MAP2K10.27371893
122JAK30.26967970
123PRKACB0.26214792
124CHUK0.25450660
125CDK30.24915709
126RPS6KA50.24884861
127PRKG20.24414795
128ADRBK20.24003907
129CSNK1D0.23957053
130CSNK1A10.23654077
131CSNK1E0.23489732
132MKNK20.23229871
133DAPK10.22840384
134PRKDC0.22689934
135GSK3A0.22270807
136IRAK30.21760258
137RIPK10.21605868
138PRKD10.21015885
139IGF1R0.20355901
140PRKACG0.19388510
141CAMK2B0.19107973
142CDK50.18962807
143TEC0.17395582
144PRKACA0.17191688
145BTK0.16869943
146AKT30.16637694
147PRKAA10.16241490
148CAMKK10.14001020
149PRKCG0.13328360
150NEK60.12877377
151MARK20.12861818
152MAPK140.11903199
153MAPK30.11671196
154MAPKAPK20.11189144
155MAPK100.10661044
156PRKCA0.10583312
157DYRK20.10512249
158MAPK90.10123446
159VRK10.09760540
160ERBB40.08211733
161RPS6KA30.07096223

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.88100084
2Protein export_Homo sapiens_hsa030605.73765288
3Insulin secretion_Homo sapiens_hsa049113.21359449
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.20630026
5Sulfur metabolism_Homo sapiens_hsa009203.19377044
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80497712
7Vibrio cholerae infection_Homo sapiens_hsa051102.36822865
8Type I diabetes mellitus_Homo sapiens_hsa049402.21831119
9Type II diabetes mellitus_Homo sapiens_hsa049302.09546192
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88711591
11N-Glycan biosynthesis_Homo sapiens_hsa005101.76336680
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.74491159
13Folate biosynthesis_Homo sapiens_hsa007901.63841012
14Cocaine addiction_Homo sapiens_hsa050301.60793017
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60124930
16Lysosome_Homo sapiens_hsa041421.59079996
17Selenocompound metabolism_Homo sapiens_hsa004501.58582264
18Vitamin B6 metabolism_Homo sapiens_hsa007501.56317651
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.50501210
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49911611
21Other glycan degradation_Homo sapiens_hsa005111.42782861
22Circadian rhythm_Homo sapiens_hsa047101.34769887
23Regulation of autophagy_Homo sapiens_hsa041401.27500328
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26524664
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15772522
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13843886
27Glucagon signaling pathway_Homo sapiens_hsa049221.10767689
28Amphetamine addiction_Homo sapiens_hsa050311.08027230
29beta-Alanine metabolism_Homo sapiens_hsa004101.06332171
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06156801
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05681485
32Prion diseases_Homo sapiens_hsa050201.02767396
33Propanoate metabolism_Homo sapiens_hsa006400.98218745
34Pancreatic secretion_Homo sapiens_hsa049720.97953527
35ABC transporters_Homo sapiens_hsa020100.94724578
36Ovarian steroidogenesis_Homo sapiens_hsa049130.92589687
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90042264
38Thyroid hormone synthesis_Homo sapiens_hsa049180.89616907
39Tryptophan metabolism_Homo sapiens_hsa003800.88909803
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88793860
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87449615
42Taste transduction_Homo sapiens_hsa047420.87232601
43Mineral absorption_Homo sapiens_hsa049780.83392230
44Galactose metabolism_Homo sapiens_hsa000520.77101091
45Phototransduction_Homo sapiens_hsa047440.76905516
46Butanoate metabolism_Homo sapiens_hsa006500.73555289
47Circadian entrainment_Homo sapiens_hsa047130.73279614
48GABAergic synapse_Homo sapiens_hsa047270.72555444
49Synaptic vesicle cycle_Homo sapiens_hsa047210.71874782
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71582962
51Dopaminergic synapse_Homo sapiens_hsa047280.71406789
52Collecting duct acid secretion_Homo sapiens_hsa049660.71296495
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69411961
54Insulin resistance_Homo sapiens_hsa049310.69398156
55Linoleic acid metabolism_Homo sapiens_hsa005910.68613961
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66987726
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65823187
58Alcoholism_Homo sapiens_hsa050340.64359800
59Serotonergic synapse_Homo sapiens_hsa047260.61578406
60Estrogen signaling pathway_Homo sapiens_hsa049150.59238866
61Prolactin signaling pathway_Homo sapiens_hsa049170.58666571
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58294920
63Salivary secretion_Homo sapiens_hsa049700.58199147
64mTOR signaling pathway_Homo sapiens_hsa041500.57690487
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57457266
66Dorso-ventral axis formation_Homo sapiens_hsa043200.57295354
67Sphingolipid metabolism_Homo sapiens_hsa006000.55345629
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55169209
69Steroid biosynthesis_Homo sapiens_hsa001000.53552095
70Long-term potentiation_Homo sapiens_hsa047200.53286901
71Starch and sucrose metabolism_Homo sapiens_hsa005000.52893175
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51333818
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50746765
74Glutathione metabolism_Homo sapiens_hsa004800.50289856
75Phenylalanine metabolism_Homo sapiens_hsa003600.49860359
76Cardiac muscle contraction_Homo sapiens_hsa042600.48668195
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.46861717
78Histidine metabolism_Homo sapiens_hsa003400.46780722
79Glutamatergic synapse_Homo sapiens_hsa047240.46651590
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46440191
81Antigen processing and presentation_Homo sapiens_hsa046120.45872758
82Insulin signaling pathway_Homo sapiens_hsa049100.43626118
83Cholinergic synapse_Homo sapiens_hsa047250.41844536
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41073360
85Fat digestion and absorption_Homo sapiens_hsa049750.39888826
86Fatty acid degradation_Homo sapiens_hsa000710.38252056
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36662507
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36138057
89Legionellosis_Homo sapiens_hsa051340.35503570
90Bile secretion_Homo sapiens_hsa049760.34947067
91Retinol metabolism_Homo sapiens_hsa008300.34695441
92Fatty acid elongation_Homo sapiens_hsa000620.33729307
93Lysine degradation_Homo sapiens_hsa003100.33309011
94Chemical carcinogenesis_Homo sapiens_hsa052040.31969226
95Oxidative phosphorylation_Homo sapiens_hsa001900.30942215
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.29409179
97Renin secretion_Homo sapiens_hsa049240.29090072
98Arachidonic acid metabolism_Homo sapiens_hsa005900.28587945
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28001404
100Alzheimers disease_Homo sapiens_hsa050100.27764247
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26174667
102cAMP signaling pathway_Homo sapiens_hsa040240.25800716
103Tyrosine metabolism_Homo sapiens_hsa003500.25218504
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21625316
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21294614
106Phagosome_Homo sapiens_hsa041450.21176309
107Morphine addiction_Homo sapiens_hsa050320.20098654
108Protein digestion and absorption_Homo sapiens_hsa049740.19832144
109Thyroid cancer_Homo sapiens_hsa052160.19538267
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18159684
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17573032
112Bladder cancer_Homo sapiens_hsa052190.16294665
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.15377716
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14888360
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14046418
116Fructose and mannose metabolism_Homo sapiens_hsa000510.13305743
117Ether lipid metabolism_Homo sapiens_hsa005650.13039877
118Long-term depression_Homo sapiens_hsa047300.12920162
119Inositol phosphate metabolism_Homo sapiens_hsa005620.12878805
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12758917
121Peroxisome_Homo sapiens_hsa041460.11821627
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11654051
123Fatty acid metabolism_Homo sapiens_hsa012120.10038637
124AMPK signaling pathway_Homo sapiens_hsa041520.09608450
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09453731
126Metabolic pathways_Homo sapiens_hsa011000.09162657
127Renin-angiotensin system_Homo sapiens_hsa046140.08994353
128Gastric acid secretion_Homo sapiens_hsa049710.08602624
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08599475
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.08421147

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