KCNK18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.11225427
2detection of temperature stimulus involved in sensory perception (GO:0050961)7.11225427
3piRNA metabolic process (GO:0034587)6.60434692
4peripheral nervous system neuron development (GO:0048935)6.53356638
5detection of temperature stimulus (GO:0016048)6.37842122
6female gamete generation (GO:0007292)5.68693670
7negative regulation of homotypic cell-cell adhesion (GO:0034111)5.60502963
8negative regulation of dendrite morphogenesis (GO:0050774)5.49892000
9regulation of female gonad development (GO:2000194)5.48661277
10regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.40344020
11regulation of mitotic spindle organization (GO:0060236)4.75181420
12negative regulation of meiosis (GO:0045835)4.60616629
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.58357750
14attachment of spindle microtubules to kinetochore (GO:0008608)4.57115490
15male meiosis (GO:0007140)4.54063574
16DNA damage induced protein phosphorylation (GO:0006975)4.52833385
17regulation of meiosis (GO:0040020)4.52707650
18behavioral response to ethanol (GO:0048149)4.48219086
19mitotic chromosome condensation (GO:0007076)4.43547144
20neuronal action potential (GO:0019228)4.39366654
21mitotic metaphase plate congression (GO:0007080)4.20292297
22sphingosine metabolic process (GO:0006670)4.11636798
23notochord development (GO:0030903)4.08912034
24adenosine metabolic process (GO:0046085)3.98110562
25meiotic cell cycle (GO:0051321)3.97134537
26negative regulation of complement activation (GO:0045916)3.96458385
27histone H2A monoubiquitination (GO:0035518)3.95584479
28DNA methylation involved in gamete generation (GO:0043046)3.91639973
29regulation of spindle organization (GO:0090224)3.91457680
30inner cell mass cell proliferation (GO:0001833)3.83340806
31histone H2A ubiquitination (GO:0033522)3.83166747
32regulation of platelet aggregation (GO:0090330)3.67901365
33protein polyglutamylation (GO:0018095)3.65047593
34negative regulation of cAMP-mediated signaling (GO:0043951)3.64687441
35oocyte maturation (GO:0001556)3.62174963
36oogenesis (GO:0048477)3.62077911
37phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.60064986
38membrane budding (GO:0006900)3.59690723
39adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.59680407
40diol metabolic process (GO:0034311)3.58062597
41regulation of meiotic cell cycle (GO:0051445)3.57021531
42membrane depolarization during action potential (GO:0086010)3.45453422
43negative regulation of dendrite development (GO:2000171)3.41386849
44negative regulation of smooth muscle cell differentiation (GO:0051151)3.40498862
45negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.38544831
46regulation of meiosis I (GO:0060631)3.37633866
47neurofilament cytoskeleton organization (GO:0060052)3.37393683
48meiotic chromosome segregation (GO:0045132)3.37123961
49metaphase plate congression (GO:0051310)3.30294505
50microtubule polymerization or depolymerization (GO:0031109)3.30242161
51phosphatidylglycerol biosynthetic process (GO:0006655)3.27579385
52cell migration in hindbrain (GO:0021535)3.26618430
53establishment of chromosome localization (GO:0051303)3.25019973
54negative regulation of meiotic cell cycle (GO:0051447)3.24053586
55retinal ganglion cell axon guidance (GO:0031290)3.23921051
56negative regulation of protein activation cascade (GO:2000258)3.18490256
57sphingoid metabolic process (GO:0046519)3.18111268
58negative regulation of hormone biosynthetic process (GO:0032353)3.14271368
59negative regulation of hormone metabolic process (GO:0032351)3.14271368
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14231361
61protein K6-linked ubiquitination (GO:0085020)3.11202494
62female gonad development (GO:0008585)3.10743863
63regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.10642814
64negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.06131465
65positive regulation of Cdc42 GTPase activity (GO:0043089)3.03096019
66detection of mechanical stimulus involved in sensory perception (GO:0050974)2.96063344
67negative regulation of microtubule depolymerization (GO:0007026)2.95987674
68ribosome assembly (GO:0042255)2.94749882
69regulation of sister chromatid cohesion (GO:0007063)2.94597447
70regulation of exit from mitosis (GO:0007096)2.93782881
71proline transport (GO:0015824)2.92817238
72regulation of early endosome to late endosome transport (GO:2000641)2.92400535
73maturation of 5.8S rRNA (GO:0000460)2.90207958
74myoblast migration (GO:0051451)2.89059986
75glycerophospholipid catabolic process (GO:0046475)2.88053809
76neuronal action potential propagation (GO:0019227)2.87755081
77regulation of Golgi to plasma membrane protein transport (GO:0042996)2.87727767
78response to pain (GO:0048265)2.87213041
79regulation of cell maturation (GO:1903429)2.86668032
80regulation of microtubule depolymerization (GO:0031114)2.86133505
81regulation of DNA methylation (GO:0044030)2.82407322
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81941597
83regulation of cAMP-dependent protein kinase activity (GO:2000479)2.81434551
84regulation of histone phosphorylation (GO:0033127)2.79385123
85positive regulation of vesicle fusion (GO:0031340)2.76779439
86chaperone-mediated protein transport (GO:0072321)2.75270013
87cytoskeleton-dependent cytokinesis (GO:0061640)2.75153206
88DNA damage response, signal transduction resulting in transcription (GO:0042772)2.73923113
89multicellular organism reproduction (GO:0032504)2.71287058
90negative regulation of calcium ion transport into cytosol (GO:0010523)2.70343908
91DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.68323697
92mitotic sister chromatid segregation (GO:0000070)2.65471032
93snRNA transcription (GO:0009301)2.64798936
94response to water (GO:0009415)2.63504700
95inactivation of MAPK activity (GO:0000188)2.62823267
96aggressive behavior (GO:0002118)2.62471239
97dopamine receptor signaling pathway (GO:0007212)2.60904925
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59391463
99regulation of homotypic cell-cell adhesion (GO:0034110)2.58697587
100detection of mechanical stimulus (GO:0050982)2.56981630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human3.80983099
2MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87320487
3ESR1_20079471_ChIP-ChIP_T-47D_Human2.84299009
4VDR_22108803_ChIP-Seq_LS180_Human2.49085479
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22693882
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.18254493
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08701506
8AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08280875
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02874591
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01558712
11GBX2_23144817_ChIP-Seq_PC3_Human2.01352908
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87241644
13SMAD4_21799915_ChIP-Seq_A2780_Human1.81335945
14STAT3_23295773_ChIP-Seq_U87_Human1.81268363
15RNF2_27304074_Chip-Seq_NSC_Mouse1.79746355
16FOXM1_23109430_ChIP-Seq_U2OS_Human1.79244051
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79093890
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69182969
19CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64843067
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64464222
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64109243
22MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61578741
23MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59918066
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58828139
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.55398686
26EZH2_22144423_ChIP-Seq_EOC_Human1.53289790
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.51591649
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49343478
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49343478
30PRDM14_20953172_ChIP-Seq_ESCs_Human1.48877540
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45748758
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43274049
33TAF15_26573619_Chip-Seq_HEK293_Human1.42223288
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.42199585
35TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41605225
36KDM2B_26808549_Chip-Seq_REH_Human1.41313068
37IGF1R_20145208_ChIP-Seq_DFB_Human1.40943437
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40161202
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38509115
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.35997514
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.35978570
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35831146
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.35321540
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32363585
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31702120
46CJUN_26792858_Chip-Seq_BT549_Human1.30894257
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.30598299
48BCAT_22108803_ChIP-Seq_LS180_Human1.29558351
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28727088
50P300_19829295_ChIP-Seq_ESCs_Human1.26115988
51CDX2_22108803_ChIP-Seq_LS180_Human1.25816757
52AR_21909140_ChIP-Seq_LNCAP_Human1.25057490
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24592407
54AR_25329375_ChIP-Seq_VCAP_Human1.23229727
55JUN_21703547_ChIP-Seq_K562_Human1.22943868
56STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22791402
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22430722
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21773821
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20430671
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19571546
61NFYA_21822215_ChIP-Seq_K562_Human1.18799506
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18121995
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.17375450
64TBL1_22424771_ChIP-Seq_293T_Human1.17326688
65STAT1_17558387_ChIP-Seq_HELA_Human1.16394975
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16137894
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15201815
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14905084
69NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14538200
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14228421
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14218889
72SOX2_19829295_ChIP-Seq_ESCs_Human1.14061861
73NANOG_19829295_ChIP-Seq_ESCs_Human1.14061861
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14016009
75AR_21572438_ChIP-Seq_LNCaP_Human1.13660190
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13304460
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13098044
78* TCF4_23295773_ChIP-Seq_U87_Human1.12921548
79ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12279506
80ETV1_20927104_ChIP-Seq_GIST48_Human1.11431474
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.10743965
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10601645
83PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06878841
84SMAD3_21741376_ChIP-Seq_ESCs_Human1.06796112
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05965432
86* TP63_23658742_ChIP-Seq_EP156T_Human1.05472478
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05130622
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04172236
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.04075325
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03439126
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03439126
92REST_21632747_ChIP-Seq_MESCs_Mouse1.02656180
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.02429699
94* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00945245
95AHR_22903824_ChIP-Seq_MCF-7_Human1.00369579
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00351949
97CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99649421
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.99475091
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98795887
100RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98343898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception6.16527234
2MP0001986_abnormal_taste_sensitivity5.87097509
3MP0002736_abnormal_nociception_after5.13944966
4MP0004270_analgesia4.81263339
5MP0002735_abnormal_chemical_nociception4.60687786
6MP0006276_abnormal_autonomic_nervous3.79408434
7MP0002733_abnormal_thermal_nociception3.76472439
8MP0003718_maternal_effect3.76127928
9MP0005451_abnormal_body_composition3.54591006
10MP0002734_abnormal_mechanical_nocicepti3.40527717
11MP0004858_abnormal_nervous_system3.04681023
12MP0001970_abnormal_pain_threshold2.90184078
13MP0003646_muscle_fatigue2.75845929
14MP0002653_abnormal_ependyma_morphology2.62747576
15MP0003693_abnormal_embryo_hatching2.15248679
16MP0008877_abnormal_DNA_methylation2.06530040
17MP0000579_abnormal_nail_morphology1.92497419
18MP0008260_abnormal_autophagy1.87922794
19MP0003787_abnormal_imprinting1.74460312
20MP0002184_abnormal_innervation1.66021742
21MP0004859_abnormal_synaptic_plasticity1.64956682
22MP0005395_other_phenotype1.64951425
23MP0003699_abnormal_female_reproductive1.64345292
24MP0010234_abnormal_vibrissa_follicle1.55503716
25MP0002067_abnormal_sensory_capabilities1.55258651
26MP0001905_abnormal_dopamine_level1.46543811
27MP0003329_amyloid_beta_deposits1.42544218
28MP0001119_abnormal_female_reproductive1.39462683
29MP0004185_abnormal_adipocyte_glucose1.36686021
30MP0001929_abnormal_gametogenesis1.31929594
31MP0001270_distended_abdomen1.27484526
32MP0000372_irregular_coat_pigmentation1.25113286
33MP0005408_hypopigmentation1.22593525
34MP0003937_abnormal_limbs/digits/tail_de1.21886361
35MP0010094_abnormal_chromosome_stability1.21262640
36MP0002272_abnormal_nervous_system1.19337919
37MP0009697_abnormal_copulation1.19332841
38MP0003315_abnormal_perineum_morphology1.18047568
39MP0008932_abnormal_embryonic_tissue1.16128557
40MP0003077_abnormal_cell_cycle1.15865007
41MP0002102_abnormal_ear_morphology1.09400473
42MP0000653_abnormal_sex_gland1.08509163
43MP0002751_abnormal_autonomic_nervous1.08356126
44MP0001984_abnormal_olfaction1.08308969
45MP0002210_abnormal_sex_determination1.06601063
46MP0003111_abnormal_nucleus_morphology1.04407285
47MP0000955_abnormal_spinal_cord1.02874700
48MP0010386_abnormal_urinary_bladder1.02551766
49MP0000427_abnormal_hair_cycle1.00786464
50MP0000538_abnormal_urinary_bladder0.94601646
51MP0005423_abnormal_somatic_nervous0.94455290
52MP0002161_abnormal_fertility/fecundity0.93130012
53MP0005187_abnormal_penis_morphology0.91166930
54MP0000462_abnormal_digestive_system0.90637015
55MP0000639_abnormal_adrenal_gland0.89520279
56MP0003635_abnormal_synaptic_transmissio0.87979380
57MP0004957_abnormal_blastocyst_morpholog0.85693284
58MP0003656_abnormal_erythrocyte_physiolo0.81897909
59MP0003632_abnormal_nervous_system0.81653379
60MP0002063_abnormal_learning/memory/cond0.79076563
61MP0005310_abnormal_salivary_gland0.78676629
62MP0002249_abnormal_larynx_morphology0.76808894
63MP0002837_dystrophic_cardiac_calcinosis0.76614966
64MP0010771_integument_phenotype0.75396905
65MP0001529_abnormal_vocalization0.74853533
66MP0002752_abnormal_somatic_nervous0.71552566
67MP0002882_abnormal_neuron_morphology0.71480711
68MP0001346_abnormal_lacrimal_gland0.68137881
69MP0000534_abnormal_ureter_morphology0.67676162
70MP0002572_abnormal_emotion/affect_behav0.65243748
71MP0003121_genomic_imprinting0.65071426
72MP0003890_abnormal_embryonic-extraembry0.64515926
73MP0008874_decreased_physiological_sensi0.64371480
74MP0000778_abnormal_nervous_system0.63971707
75MP0004742_abnormal_vestibular_system0.62086684
76MP0001915_intracranial_hemorrhage0.60642099
77MP0001145_abnormal_male_reproductive0.58333588
78MP0003698_abnormal_male_reproductive0.57402565
79MP0002085_abnormal_embryonic_tissue0.57048610
80MP0005397_hematopoietic_system_phenotyp0.56350346
81MP0001545_abnormal_hematopoietic_system0.56350346
82MP0003631_nervous_system_phenotype0.56092073
83MP0009745_abnormal_behavioral_response0.55934256
84MP0004811_abnormal_neuron_physiology0.55346409
85MP0001849_ear_inflammation0.55116916
86MP0001919_abnormal_reproductive_system0.53510324
87MP0005646_abnormal_pituitary_gland0.52545947
88MP0001502_abnormal_circadian_rhythm0.52403156
89MP0009278_abnormal_bone_marrow0.51436046
90MP0003880_abnormal_central_pattern0.50949958
91MP0001299_abnormal_eye_distance/0.50860773
92MP0006292_abnormal_olfactory_placode0.50509348
93MP0004484_altered_response_of0.50327900
94MP0002084_abnormal_developmental_patter0.49725093
95MP0003091_abnormal_cell_migration0.48871078
96MP0003861_abnormal_nervous_system0.48849173
97MP0004924_abnormal_behavior0.48486927
98MP0005386_behavior/neurological_phenoty0.48486927
99MP0002066_abnormal_motor_capabilities/c0.47699142
100MP0000350_abnormal_cell_proliferation0.46208821

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.57837830
2Papillary thyroid carcinoma (HP:0002895)5.95646730
3Thyroid carcinoma (HP:0002890)5.49385861
4Ulnar claw (HP:0001178)5.26481941
5Termporal pattern (HP:0011008)4.61074019
6Insidious onset (HP:0003587)4.61074019
7Dysautonomia (HP:0002459)4.21445116
8Cortical dysplasia (HP:0002539)3.84004418
9Lip pit (HP:0100267)3.77652606
10Myokymia (HP:0002411)3.53034157
11Autoamputation (HP:0001218)3.49404598
12Metaphyseal dysplasia (HP:0100255)3.46806037
13Premature ovarian failure (HP:0008209)3.45101905
14Overlapping toe (HP:0001845)3.30885997
15Abnormality of pain sensation (HP:0010832)3.25033542
16Impaired pain sensation (HP:0007328)3.25033542
17Focal motor seizures (HP:0011153)3.22757149
18Adrenal hypoplasia (HP:0000835)3.21184281
19Shawl scrotum (HP:0000049)3.19803628
20Facial hemangioma (HP:0000329)3.12631604
21Chin dimple (HP:0010751)3.10400957
22Abnormality of the labia minora (HP:0012880)2.99007727
23Flat capital femoral epiphysis (HP:0003370)2.98901462
24Atonic seizures (HP:0010819)2.87439389
25Acute myeloid leukemia (HP:0004808)2.86900201
26Abnormal hemoglobin (HP:0011902)2.86304098
27Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.85481105
28Abnormality of the corticospinal tract (HP:0002492)2.84577746
29Abnormality of the epiphysis of the femoral head (HP:0010574)2.84250650
30Infertility (HP:0000789)2.81497300
31Hammertoe (HP:0001765)2.77729860
32Neoplasm of the thyroid gland (HP:0100031)2.71035958
33Chromsome breakage (HP:0040012)2.65886157
34Hypothermia (HP:0002045)2.63117929
35Abnormality of the femoral head (HP:0003368)2.61061056
36Anosmia (HP:0000458)2.57400036
37Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.55804498
38Abnormality of femoral epiphyses (HP:0006499)2.55804498
39Steppage gait (HP:0003376)2.52601991
40Breast hypoplasia (HP:0003187)2.51492360
41Birth length less than 3rd percentile (HP:0003561)2.48535366
42Action tremor (HP:0002345)2.48353558
43Segmental peripheral demyelination/remyelination (HP:0003481)2.47822206
44Abnormality of the costochondral junction (HP:0000919)2.47356692
45Abnormal autonomic nervous system physiology (HP:0012332)2.43976622
46Hypomagnesemia (HP:0002917)2.43523582
47Breast aplasia (HP:0100783)2.41808491
48Focal seizures (HP:0007359)2.38401872
49Patellar aplasia (HP:0006443)2.36279599
50Long toe (HP:0010511)2.34778145
51Aplasia/Hypoplasia of the breasts (HP:0010311)2.33443848
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32570044
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.31341776
54Insulin-resistant diabetes mellitus (HP:0000831)2.29966324
55Urinary bladder sphincter dysfunction (HP:0002839)2.29237530
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29209904
57Camptodactyly of toe (HP:0001836)2.28498588
58Secondary amenorrhea (HP:0000869)2.27610004
59Facial shape deformation (HP:0011334)2.20233465
60Potter facies (HP:0002009)2.20233465
61Febrile seizures (HP:0002373)2.20200707
62Sparse lateral eyebrow (HP:0005338)2.18262632
63Abnormality of magnesium homeostasis (HP:0004921)2.17465210
64Cholecystitis (HP:0001082)2.15433641
65Abnormal gallbladder physiology (HP:0012438)2.15433641
66Areflexia of lower limbs (HP:0002522)2.13462125
67Prostate neoplasm (HP:0100787)2.12297219
68Primary amenorrhea (HP:0000786)2.12096152
69Anterior segment dysgenesis (HP:0007700)2.10567582
70Onion bulb formation (HP:0003383)2.08571048
71Arthropathy (HP:0003040)2.08325126
72Aplasia/Hypoplasia of the patella (HP:0006498)2.08309448
73Abnormal hair whorl (HP:0010721)2.02696199
74Neonatal respiratory distress (HP:0002643)2.01322030
75Fetal akinesia sequence (HP:0001989)1.99961499
76Microglossia (HP:0000171)1.97563677
77Hypoplastic iliac wings (HP:0002866)1.97505460
78Abnormality of lateral ventricle (HP:0030047)1.97275887
79Abnormality of the fingertips (HP:0001211)1.96819549
80Decreased muscle mass (HP:0003199)1.96624398
81Capillary hemangiomas (HP:0005306)1.93586170
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92688284
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.92206761
84Oligodactyly (HP:0012165)1.86597824
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85118491
86Degeneration of the lateral corticospinal tracts (HP:0002314)1.85118491
87Posterior embryotoxon (HP:0000627)1.84902969
88Abnormality of chromosome segregation (HP:0002916)1.84544688
89Thoracolumbar scoliosis (HP:0002944)1.84425632
90Sensorimotor neuropathy (HP:0007141)1.82259111
91Spastic gait (HP:0002064)1.82204416
92Abnormality of the line of Schwalbe (HP:0008048)1.81223538
93Aplasia involving bones of the upper limbs (HP:0009823)1.80268807
94Aplasia of the phalanges of the hand (HP:0009802)1.80268807
95Aplasia involving bones of the extremities (HP:0009825)1.80268807
96Distal sensory impairment (HP:0002936)1.78763480
97Knee flexion contracture (HP:0006380)1.77298285
98Foot dorsiflexor weakness (HP:0009027)1.77170939
99Cerebral hypomyelination (HP:0006808)1.76384411
100Genital tract atresia (HP:0001827)1.74581558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.82165310
2LATS15.74221114
3STK38L4.62639001
4NTRK13.47668059
5MAP3K93.45937576
6KSR23.27069058
7ERBB43.01171807
8MAP3K62.88812296
9ARAF2.02937118
10TAOK11.89762775
11TAOK31.84689689
12BRAF1.82231834
13MATK1.77809495
14PAK61.75574389
15MAP3K41.74680511
16PLK41.64420931
17STK381.60224436
18CDC71.59077515
19CDK81.58462693
20ADRBK21.55410970
21MUSK1.51754042
22TTK1.50893599
23MAPKAPK31.44244937
24STK31.39920589
25RAF11.35428466
26RET1.34343933
27MOS1.31521720
28DYRK21.30081408
29PRKD31.27035890
30LMTK21.25265771
31RIPK41.23710213
32MAP3K131.20669392
33MAP2K41.17864962
34ABL21.17648827
35MAP2K71.16409052
36MAP3K21.13978857
37CHEK21.07387340
38MAPK131.05868640
39EPHA31.02965982
40MINK11.02886806
41SIK31.02390781
42KSR10.97667958
43STK240.84940179
44CSNK1G20.78183874
45CSNK1G10.75155956
46TYRO30.73143574
47GRK50.72679364
48SGK2230.69314339
49SGK4940.69314339
50AURKA0.68932841
51DMPK0.66976829
52LIMK10.66594370
53SGK20.65606999
54EEF2K0.62802361
55MAP2K10.62235989
56CSNK1G30.61412007
57MAP3K10.60389560
58BMPR1B0.59568237
59NEK90.58136172
60MAP3K120.57350107
61MAP3K80.57175830
62BMPR20.55801416
63STK100.55714986
64MELK0.54712587
65MARK30.53036422
66ADRBK10.52403276
67PLK10.51042862
68BCR0.50299159
69CSNK1A1L0.50227934
70CDK90.49865907
71PRKAA10.47767077
72PDGFRB0.47517746
73TRPM70.45393410
74FER0.43245857
75NTRK20.42939119
76CASK0.42350662
77NTRK30.41571869
78MAPK100.41441665
79NLK0.39867755
80MARK20.37432759
81CAMK2A0.36045643
82ABL10.30647530
83SGK30.27745812
84NEK10.27728387
85PRKD20.26959306
86ROCK10.26229336
87ERBB20.25654791
88PRKAA20.25114475
89HIPK20.24698193
90PINK10.23426570
91ATM0.22925703
92PLK20.22384257
93PRKCE0.21758672
94RPS6KA20.21221702
95PRKG20.19233930
96PRKCG0.17638031
97CDK10.17187164
98AURKB0.16453924
99CSNK1D0.16103608
100PHKG20.15559164

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.87653234
2Thyroid cancer_Homo sapiens_hsa052162.59579752
3Cell cycle_Homo sapiens_hsa041102.37809729
4Oocyte meiosis_Homo sapiens_hsa041142.23922914
5Ovarian steroidogenesis_Homo sapiens_hsa049132.21199992
6Circadian rhythm_Homo sapiens_hsa047102.01136544
7Synaptic vesicle cycle_Homo sapiens_hsa047211.98187351
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97507442
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.94157930
10Pancreatic cancer_Homo sapiens_hsa052121.91520531
11GnRH signaling pathway_Homo sapiens_hsa049121.85614413
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84293471
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.82888148
14Choline metabolism in cancer_Homo sapiens_hsa052311.77212704
15Prolactin signaling pathway_Homo sapiens_hsa049171.76376022
16Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.75976772
17Vitamin B6 metabolism_Homo sapiens_hsa007501.72859403
18Basal transcription factors_Homo sapiens_hsa030221.71400258
19Ether lipid metabolism_Homo sapiens_hsa005651.59154242
20RNA degradation_Homo sapiens_hsa030181.58082790
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.56121267
22TGF-beta signaling pathway_Homo sapiens_hsa043501.41151746
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38044941
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35642031
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30937807
26Melanoma_Homo sapiens_hsa052181.29405616
27Olfactory transduction_Homo sapiens_hsa047401.29171798
28Phospholipase D signaling pathway_Homo sapiens_hsa040721.26426524
29Insulin secretion_Homo sapiens_hsa049111.26307821
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23326402
31ErbB signaling pathway_Homo sapiens_hsa040121.19138387
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19094056
33Sphingolipid metabolism_Homo sapiens_hsa006001.17446283
34Serotonergic synapse_Homo sapiens_hsa047261.16044468
35p53 signaling pathway_Homo sapiens_hsa041151.13229322
36Taste transduction_Homo sapiens_hsa047421.13155670
37Endometrial cancer_Homo sapiens_hsa052131.12388562
38Estrogen signaling pathway_Homo sapiens_hsa049151.11732102
39VEGF signaling pathway_Homo sapiens_hsa043701.11626029
40Ras signaling pathway_Homo sapiens_hsa040141.09189681
41Dopaminergic synapse_Homo sapiens_hsa047281.08564016
42Long-term depression_Homo sapiens_hsa047301.06844847
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06614604
44Hedgehog signaling pathway_Homo sapiens_hsa043401.05628436
45Colorectal cancer_Homo sapiens_hsa052101.04774843
46Glutamatergic synapse_Homo sapiens_hsa047241.03245298
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01795230
48mTOR signaling pathway_Homo sapiens_hsa041501.00962192
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98478506
50Cholinergic synapse_Homo sapiens_hsa047250.95543846
51Glioma_Homo sapiens_hsa052140.95130271
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93512986
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91930062
54Hippo signaling pathway_Homo sapiens_hsa043900.90640098
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.90116432
56MicroRNAs in cancer_Homo sapiens_hsa052060.87805697
57Fanconi anemia pathway_Homo sapiens_hsa034600.87041031
58Linoleic acid metabolism_Homo sapiens_hsa005910.85556977
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.85029456
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84476536
61Salivary secretion_Homo sapiens_hsa049700.80967946
62Glycerolipid metabolism_Homo sapiens_hsa005610.80302561
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79564813
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.79241795
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76337569
66Homologous recombination_Homo sapiens_hsa034400.75370471
67Regulation of autophagy_Homo sapiens_hsa041400.74034096
68Mineral absorption_Homo sapiens_hsa049780.73617876
69Non-small cell lung cancer_Homo sapiens_hsa052230.71747564
70Non-homologous end-joining_Homo sapiens_hsa034500.71278275
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70592778
72Melanogenesis_Homo sapiens_hsa049160.70247326
73Long-term potentiation_Homo sapiens_hsa047200.68596189
74Renal cell carcinoma_Homo sapiens_hsa052110.68077062
75MAPK signaling pathway_Homo sapiens_hsa040100.67686351
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67361509
77FoxO signaling pathway_Homo sapiens_hsa040680.67341360
78Other glycan degradation_Homo sapiens_hsa005110.66379369
79cAMP signaling pathway_Homo sapiens_hsa040240.62783344
80Insulin signaling pathway_Homo sapiens_hsa049100.61877330
81Rap1 signaling pathway_Homo sapiens_hsa040150.59024637
82Endocytosis_Homo sapiens_hsa041440.58693606
83Nicotine addiction_Homo sapiens_hsa050330.57646538
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57610774
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55501928
86Gap junction_Homo sapiens_hsa045400.55309036
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55030365
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53608405
89Adherens junction_Homo sapiens_hsa045200.49832797
90Axon guidance_Homo sapiens_hsa043600.49266377
91Steroid biosynthesis_Homo sapiens_hsa001000.49226992
92Shigellosis_Homo sapiens_hsa051310.48069977
93Circadian entrainment_Homo sapiens_hsa047130.47708450
94Morphine addiction_Homo sapiens_hsa050320.47506197
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46740303
96Viral myocarditis_Homo sapiens_hsa054160.43060106
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42003747
98Inositol phosphate metabolism_Homo sapiens_hsa005620.40640476
99Bladder cancer_Homo sapiens_hsa052190.38021263
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37901056

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