KCNK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.18835083
2sarcomere organization (GO:0045214)7.08314062
3tricarboxylic acid cycle (GO:0006099)6.37492078
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.20087264
5myofibril assembly (GO:0030239)6.10553203
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.99040107
7negative regulation of potassium ion transmembrane transport (GO:1901380)5.78943770
8cardiac muscle contraction (GO:0060048)5.68628896
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.63852730
10regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.56615909
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.54356916
12C21-steroid hormone biosynthetic process (GO:0006700)5.51569344
13regulation of actin filament-based movement (GO:1903115)5.15252198
14cardiac muscle cell development (GO:0055013)5.14412831
15regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.13923587
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.12681899
17adult heart development (GO:0007512)4.86663668
18cardiac cell development (GO:0055006)4.79577170
19regulation of relaxation of muscle (GO:1901077)4.78045903
20NADH metabolic process (GO:0006734)4.74665926
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.73004127
22carnitine shuttle (GO:0006853)4.72476843
23regulation of acyl-CoA biosynthetic process (GO:0050812)4.71998677
24ventricular cardiac muscle cell action potential (GO:0086005)4.69492673
25cardiac muscle hypertrophy (GO:0003300)4.65776081
26plasma membrane repair (GO:0001778)4.64592419
27muscle filament sliding (GO:0030049)4.61802820
28actin-myosin filament sliding (GO:0033275)4.61802820
29ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.61083132
30cardiac muscle tissue morphogenesis (GO:0055008)4.53378479
31actomyosin structure organization (GO:0031032)4.47549751
32cell communication involved in cardiac conduction (GO:0086065)4.43952580
33cell communication by electrical coupling (GO:0010644)4.42911516
34striated muscle hypertrophy (GO:0014897)4.39551415
35bundle of His cell to Purkinje myocyte communication (GO:0086069)4.37653606
36regulation of cofactor metabolic process (GO:0051193)4.36385907
37regulation of coenzyme metabolic process (GO:0051196)4.36385907
38cellular response to epinephrine stimulus (GO:0071872)4.35591321
39glucocorticoid biosynthetic process (GO:0006704)4.30864640
40regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.30104394
41regulation of striated muscle contraction (GO:0006942)4.29513190
42regulation of the force of heart contraction (GO:0002026)4.25545645
43regulation of cell communication by electrical coupling (GO:0010649)4.25518660
44regulation of sequestering of triglyceride (GO:0010889)4.23081553
45regulation of membrane repolarization (GO:0060306)4.20359776
46heart trabecula formation (GO:0060347)4.16023351
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.14197542
48regulation of sarcomere organization (GO:0060297)4.12340695
49hormone biosynthetic process (GO:0042446)4.10699808
50striated muscle contraction (GO:0006941)4.08145876
51response to epinephrine (GO:0071871)4.07946891
52fatty acid transmembrane transport (GO:1902001)4.06418557
53muscle tissue morphogenesis (GO:0060415)4.02493621
54toxin metabolic process (GO:0009404)4.01863177
55cellular response to gonadotropin stimulus (GO:0071371)4.00948912
56regulation of skeletal muscle contraction (GO:0014819)4.00442094
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94663594
58regulation of cardiac muscle contraction (GO:0055117)3.94314595
59regulation of cardiac muscle cell contraction (GO:0086004)3.91467666
60respiratory electron transport chain (GO:0022904)3.88692130
61muscle hypertrophy (GO:0014896)3.84985963
62actin-mediated cell contraction (GO:0070252)3.82771820
63electron transport chain (GO:0022900)3.80324186
64relaxation of cardiac muscle (GO:0055119)3.76641268
65ketone biosynthetic process (GO:0042181)3.76144489
66estrogen biosynthetic process (GO:0006703)3.74148178
67negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.71526778
68heart process (GO:0003015)3.71464894
69heart contraction (GO:0060047)3.71464894
70glucocorticoid metabolic process (GO:0008211)3.65980510
71regulation of heart rate (GO:0002027)3.62471457
72sarcoplasmic reticulum calcium ion transport (GO:0070296)3.61086181
73ATP synthesis coupled proton transport (GO:0015986)3.60303868
74energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60303868
75benzene-containing compound metabolic process (GO:0042537)3.59989252
76response to follicle-stimulating hormone (GO:0032354)3.57055227
77cellular response to antibiotic (GO:0071236)3.52708504
78carnitine transmembrane transport (GO:1902603)3.52281622
79cardiac muscle cell action potential involved in contraction (GO:0086002)3.51363851
80cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.49909652
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.49389460
82behavioral response to nicotine (GO:0035095)3.49384990
83cardiac muscle cell action potential (GO:0086001)3.48673777
84oxidative phosphorylation (GO:0006119)3.45776193
852-oxoglutarate metabolic process (GO:0006103)3.45263160
86cardiac muscle adaptation (GO:0014887)3.44499343
87cardiac muscle hypertrophy in response to stress (GO:0014898)3.44499343
88muscle hypertrophy in response to stress (GO:0003299)3.44499343
89regulation of heart contraction (GO:0008016)3.44126254
90regulation of sulfur metabolic process (GO:0042762)3.43811171
91C21-steroid hormone metabolic process (GO:0008207)3.42838456
92cellular response to toxic substance (GO:0097237)3.40580905
93regulation of cardioblast differentiation (GO:0051890)3.38798168
94regulation of fatty acid oxidation (GO:0046320)3.38671884
95succinate metabolic process (GO:0006105)3.38295448
96cardiac conduction (GO:0061337)3.34719043
97negative regulation of potassium ion transport (GO:0043267)3.34195472
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.33662409
99positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33258937
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30976373
101oxygen transport (GO:0015671)3.30353213
102dendritic spine morphogenesis (GO:0060997)3.29920566
103regulation of heart rate by cardiac conduction (GO:0086091)3.28895975
104cellular response to cadmium ion (GO:0071276)3.28387361
105negative regulation of striated muscle cell apoptotic process (GO:0010664)3.28186259
106response to insecticide (GO:0017085)3.27876675
107androgen biosynthetic process (GO:0006702)3.24799521
108positive regulation of glycolytic process (GO:0045821)3.23049810
109fatty acid beta-oxidation (GO:0006635)3.21984044
110atrial cardiac muscle cell action potential (GO:0086014)3.21093739
111amino-acid betaine transport (GO:0015838)3.19076666
112carnitine transport (GO:0015879)3.19076666
113response to corticosterone (GO:0051412)3.18657540
114negative regulation of protein localization to cell surface (GO:2000009)3.18493353
115progesterone metabolic process (GO:0042448)3.15826202
116positive regulation of heart contraction (GO:0045823)3.14895513
117regulation of type B pancreatic cell apoptotic process (GO:2000674)3.14323262
118androgen metabolic process (GO:0008209)3.11440379
119positive regulation of hormone biosynthetic process (GO:0046886)3.09703829
120Leydig cell differentiation (GO:0033327)3.07400635
121insulin secretion (GO:0030073)3.07347139
122cellular ketone body metabolic process (GO:0046950)3.03570556
123endocrine pancreas development (GO:0031018)2.98517559
124water-soluble vitamin biosynthetic process (GO:0042364)2.95108642
125nitric oxide mediated signal transduction (GO:0007263)2.94807907
126membrane repolarization during action potential (GO:0086011)2.91092922
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.90799051
128regulation of triglyceride biosynthetic process (GO:0010866)2.84572208
129regulation of male gonad development (GO:2000018)2.82138133
130proline transport (GO:0015824)2.81454326
131negative regulation of hormone biosynthetic process (GO:0032353)2.81440723
132response to gonadotropin (GO:0034698)2.79782768
133negative regulation of neurological system process (GO:0031645)2.79689762
134positive regulation of triglyceride biosynthetic process (GO:0010867)2.76318158
135regulation of transmission of nerve impulse (GO:0051969)2.75767553
136positive regulation of amino acid transport (GO:0051957)2.73793634
137platelet dense granule organization (GO:0060155)2.71995425
138ketone body metabolic process (GO:1902224)2.67939418
139gamma-aminobutyric acid transport (GO:0015812)2.64616859
140negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63897538
141parental behavior (GO:0060746)2.63801064
142maternal behavior (GO:0042711)2.62044784
143regulation of female receptivity (GO:0045924)2.61796181
144negative regulation of gluconeogenesis (GO:0045721)2.60198453
145response to mineralocorticoid (GO:0051385)2.53974803
146potassium ion export (GO:0071435)2.53766925
147behavioral response to ethanol (GO:0048149)2.53530654
148regulation of steroid hormone biosynthetic process (GO:0090030)2.52815182
149glycerophospholipid catabolic process (GO:0046475)2.51729096
150response to lipoprotein particle (GO:0055094)2.51180979
151aggressive behavior (GO:0002118)2.50735699
152alanine transport (GO:0032328)2.50685704
153response to leptin (GO:0044321)2.49147099
154adrenal gland development (GO:0030325)2.47601355
155cyclic nucleotide catabolic process (GO:0009214)2.47075625
156response to pheromone (GO:0019236)2.46719135
157synaptic vesicle docking involved in exocytosis (GO:0016081)2.46097877
158detection of calcium ion (GO:0005513)2.45410160
159negative regulation of hormone metabolic process (GO:0032351)2.44792384
160regulation of glucokinase activity (GO:0033131)2.44464844
161regulation of hexokinase activity (GO:1903299)2.44464844
162inositol phosphate catabolic process (GO:0071545)2.44233129
163estrogen metabolic process (GO:0008210)2.43178149
164regulation of calcium ion-dependent exocytosis (GO:0017158)2.43044883
165positive regulation of insulin secretion (GO:0032024)2.40704777
166positive regulation of meiosis (GO:0045836)2.40193637
167L-fucose catabolic process (GO:0042355)2.39741403
168fucose catabolic process (GO:0019317)2.39741403
169L-fucose metabolic process (GO:0042354)2.39741403
170calcium ion import (GO:0070509)2.39385316
171positive regulation of hormone metabolic process (GO:0032352)2.39073272
1723-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.39029663
173purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.39029663
174* negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38259868
175regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38146429
176cAMP catabolic process (GO:0006198)2.37583049
177synaptic vesicle maturation (GO:0016188)2.35744738
178reflex (GO:0060004)2.35200315
179negative regulation of protein oligomerization (GO:0032460)2.33735937
180membrane repolarization (GO:0086009)2.31695163
181cellular response to growth hormone stimulus (GO:0071378)2.30158175
182regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.29562280
183positive regulation of peptide hormone secretion (GO:0090277)2.28978575
184macroautophagy (GO:0016236)2.27906643
185serotonin metabolic process (GO:0042428)2.26424836
186positive regulation of peptide secretion (GO:0002793)2.25017563
187membrane depolarization during action potential (GO:0086010)2.24713495
188chemosensory behavior (GO:0007635)2.24250692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.23112951
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.91185131
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.79908667
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77586824
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.46358740
6EZH2_22144423_ChIP-Seq_EOC_Human3.29347251
7TBX20_22328084_ChIP-Seq_HEART_Mouse2.92891136
8TBX20_22080862_ChIP-Seq_HEART_Mouse2.92891136
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49739842
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.47731282
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33271457
12ZNF263_19887448_ChIP-Seq_K562_Human2.29870729
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13389571
14VDR_22108803_ChIP-Seq_LS180_Human2.11992151
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03283433
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03283433
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00229707
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99621183
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98318942
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95079336
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91974946
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90677014
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90302758
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85881532
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85785430
26MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.85533508
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85392128
28CLOCK_20551151_ChIP-Seq_293T_Human1.81184863
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.80358617
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77718058
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77095713
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.76917566
33P300_19829295_ChIP-Seq_ESCs_Human1.76658196
34DROSHA_22980978_ChIP-Seq_HELA_Human1.75228448
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.74328965
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70439073
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.69862735
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69501055
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68335281
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67667142
41IGF1R_20145208_ChIP-Seq_DFB_Human1.66217934
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62769387
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62343160
44AR_25329375_ChIP-Seq_VCAP_Human1.61382377
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61044090
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59721009
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59413255
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59356939
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.57979361
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.56842872
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56641556
52GATA4_21415370_ChIP-Seq_HL-1_Mouse1.52754577
53TAF15_26573619_Chip-Seq_HEK293_Human1.50723732
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47200133
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47016100
56STAT3_23295773_ChIP-Seq_U87_Human1.46368075
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.46169945
58* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44600150
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44295652
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43065768
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42452551
62* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42244745
63TCF4_23295773_ChIP-Seq_U87_Human1.39491125
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39321353
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39066174
66* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37370677
67RNF2_27304074_Chip-Seq_NSC_Mouse1.36450755
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36272203
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35487640
70FUS_26573619_Chip-Seq_HEK293_Human1.34640671
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.32923222
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32899816
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32551756
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.32196487
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28460711
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26647634
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.25970354
78ER_23166858_ChIP-Seq_MCF-7_Human1.25510447
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24203877
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24203877
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23765051
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.23396147
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.22782128
84EWS_26573619_Chip-Seq_HEK293_Human1.21644509
85TCF4_22108803_ChIP-Seq_LS180_Human1.20551565
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20445619
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20404453
88CBP_20019798_ChIP-Seq_JUKART_Human1.19470092
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19470092
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18946999
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.18681492
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18660274
93TP53_22573176_ChIP-Seq_HFKS_Human1.18236521
94RUNX2_22187159_ChIP-Seq_PCA_Human1.18194997
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.18040035
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17120840
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.16636916
98ZNF274_21170338_ChIP-Seq_K562_Hela1.13263626
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13226561
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12594087
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.12280006
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.12204088
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11038673
104* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10620007
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.10513754
106KDM2B_26808549_Chip-Seq_K562_Human1.10373856
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10236785
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09421025
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09180517
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08287086
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07937381
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07854920
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07683937
114CTCF_27219007_Chip-Seq_Bcells_Human1.06610288
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.06143188
116* SOX2_19829295_ChIP-Seq_ESCs_Human1.05657606
117* NANOG_19829295_ChIP-Seq_ESCs_Human1.05657606
118WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05646976
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04931474
120P53_22387025_ChIP-Seq_ESCs_Mouse1.04746018
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04394222
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03445166
123* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02997879
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02939542
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02744888
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01366172
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01250981
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01170614
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.01026743
130ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00568505
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00392815
132* LXR_22292898_ChIP-Seq_THP-1_Human1.00384576
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00023100
134SOX2_21211035_ChIP-Seq_LN229_Gbm0.99825263
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99797507
136CDX2_22108803_ChIP-Seq_LS180_Human0.99588101
137* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99013576
138GBX2_23144817_ChIP-Seq_PC3_Human0.98868540
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97835418
140GATA1_19941826_ChIP-Seq_K562_Human0.96827463
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96255351
142* REST_18959480_ChIP-ChIP_MESCs_Mouse0.93648282
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.93517689
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.93304827
145* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92819810
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92613311
147TP63_22573176_ChIP-Seq_HFKS_Human0.90647476
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89943507
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.89507807
150AHR_22903824_ChIP-Seq_MCF-7_Human0.87381863
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.87314563
152BCAT_22108803_ChIP-Seq_LS180_Human0.86481513
153KDM2B_26808549_Chip-Seq_DND41_Human0.85399755
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85294736
155* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82863389
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82551863
157BP1_19119308_ChIP-ChIP_Hs578T_Human0.81906097
158SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80892571
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80675868
160* LXR_22158963_ChIP-Seq_LIVER_Mouse0.80409410
161AR_19668381_ChIP-Seq_PC3_Human0.79508379
162P68_20966046_ChIP-Seq_HELA_Human0.78244047
163REST_21632747_ChIP-Seq_MESCs_Mouse0.77822276
164PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77817627
165AR_21572438_ChIP-Seq_LNCaP_Human0.76850679
166* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76269936
167STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76031879
168* FOXA2_19822575_ChIP-Seq_HepG2_Human0.74304030
169* RUNX1_27514584_Chip-Seq_MCF-7_Human0.74225791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.75696406
2MP0004084_abnormal_cardiac_muscle5.55972753
3MP0003646_muscle_fatigue5.28395270
4MP0000751_myopathy4.76676431
5MP0004215_abnormal_myocardial_fiber4.56090559
6MP0004036_abnormal_muscle_relaxation4.03162274
7MP0005330_cardiomyopathy3.59078719
8MP0000749_muscle_degeneration3.22048911
9MP0003283_abnormal_digestive_organ3.12556398
10MP0002972_abnormal_cardiac_muscle2.99353648
11MP0003787_abnormal_imprinting2.97934045
12MP0008775_abnormal_heart_ventricle2.94481528
13MP0003137_abnormal_impulse_conducting2.83755613
14MP0004087_abnormal_muscle_fiber2.78544013
15MP0004130_abnormal_muscle_cell2.77640713
16MP0003195_calcinosis2.72974219
17MP0006138_congestive_heart_failure2.69003892
18MP0005385_cardiovascular_system_phenoty2.58142836
19MP0001544_abnormal_cardiovascular_syste2.58142836
20MP0005379_endocrine/exocrine_gland_phen2.47814747
21MP0005620_abnormal_muscle_contractility2.46365495
22MP0010630_abnormal_cardiac_muscle2.43263905
23MP0004484_altered_response_of2.40975189
24* MP0004085_abnormal_heartbeat2.33359901
25MP0000750_abnormal_muscle_regeneration2.19324813
26MP0008877_abnormal_DNA_methylation2.18394149
27MP0002106_abnormal_muscle_physiology2.09025622
28MP0006276_abnormal_autonomic_nervous2.06035161
29MP0002269_muscular_atrophy2.00988400
30MP0005670_abnormal_white_adipose2.00857572
31MP0005646_abnormal_pituitary_gland2.00676803
32MP0002876_abnormal_thyroid_physiology1.99162250
33MP0001984_abnormal_olfaction1.98344803
34MP0008875_abnormal_xenobiotic_pharmacok1.93991462
35MP0004145_abnormal_muscle_electrophysio1.91400835
36MP0003880_abnormal_central_pattern1.90289558
37MP0003828_pulmonary_edema1.90281243
38MP0003221_abnormal_cardiomyocyte_apopto1.86405778
39MP0002163_abnormal_gland_morphology1.80604361
40MP0008995_early_reproductive_senescence1.80247232
41MP0005551_abnormal_eye_electrophysiolog1.79716089
42MP0005666_abnormal_adipose_tissue1.77794015
43MP0001968_abnormal_touch/_nociception1.77305469
44MP0001501_abnormal_sleep_pattern1.75869943
45MP0000631_abnormal_neuroendocrine_gland1.75262159
46MP0006036_abnormal_mitochondrial_physio1.71112758
47MP0004510_myositis1.70907010
48MP0005369_muscle_phenotype1.70851628
49MP0004233_abnormal_muscle_weight1.70550402
50MP0010386_abnormal_urinary_bladder1.70011019
51MP0005645_abnormal_hypothalamus_physiol1.69167201
52MP0002557_abnormal_social/conspecific_i1.63212477
53MP0000759_abnormal_skeletal_muscle1.62642222
54MP0002127_abnormal_cardiovascular_syste1.62074947
55MP0002693_abnormal_pancreas_physiology1.61693893
56MP0001485_abnormal_pinna_reflex1.57384271
57MP0002572_abnormal_emotion/affect_behav1.57218619
58MP0003011_delayed_dark_adaptation1.55224596
59MP0000747_muscle_weakness1.54896759
60MP0005253_abnormal_eye_physiology1.49739570
61MP0001944_abnormal_pancreas_morphology1.48326368
62MP0001486_abnormal_startle_reflex1.48210190
63MP0002734_abnormal_mechanical_nocicepti1.46384814
64MP0001970_abnormal_pain_threshold1.45926720
65MP0004270_analgesia1.42131107
66MP0002733_abnormal_thermal_nociception1.39329522
67MP0002063_abnormal_learning/memory/cond1.38835151
68* MP0002909_abnormal_adrenal_gland1.38600738
69MP0008004_abnormal_stomach_pH1.37515830
70MP0010329_abnormal_lipoprotein_level1.36343043
71MP0003879_abnormal_hair_cell1.35870246
72MP0005375_adipose_tissue_phenotype1.33369441
73MP0002332_abnormal_exercise_endurance1.33163611
74* MP0000230_abnormal_systemic_arterial1.29110894
75MP0003121_genomic_imprinting1.27405029
76MP0004885_abnormal_endolymph1.27355039
77MP0008872_abnormal_physiological_respon1.20731699
78MP0004185_abnormal_adipocyte_glucose1.19687156
79MP0001986_abnormal_taste_sensitivity1.17073831
80MP0006035_abnormal_mitochondrial_morpho1.15909481
81MP0001905_abnormal_dopamine_level1.15116616
82MP0000343_altered_response_to1.12801117
83MP0002735_abnormal_chemical_nociception1.12147204
84MP0000013_abnormal_adipose_tissue1.10691116
85MP0003950_abnormal_plasma_membrane1.10542847
86MP0002736_abnormal_nociception_after1.10523662
87MP0000266_abnormal_heart_morphology1.10522464
88MP0001502_abnormal_circadian_rhythm1.10317432
89MP0000003_abnormal_adipose_tissue1.05153467
90MP0002234_abnormal_pharynx_morphology1.03559361
91MP0005332_abnormal_amino_acid1.03500127
92MP0005423_abnormal_somatic_nervous1.02549900
93MP0002928_abnormal_bile_duct1.02437547
94MP0003567_abnormal_fetal_cardiomyocyte1.01423187
95MP0004134_abnormal_chest_morphology1.00786058
96MP0002938_white_spotting1.00581197
97MP0000516_abnormal_urinary_system1.00223293
98MP0005367_renal/urinary_system_phenotyp1.00223293
99MP0005220_abnormal_exocrine_pancreas1.00094734
100MP0003633_abnormal_nervous_system1.00036422
101MP0010368_abnormal_lymphatic_system0.99609629
102MP0002184_abnormal_innervation0.99433925
103MP0002822_catalepsy0.98827375
104MP0003279_aneurysm0.96793080
105MP0002229_neurodegeneration0.96434694
106MP0000639_abnormal_adrenal_gland0.96028413
107MP0001756_abnormal_urination0.95781562
108MP0005365_abnormal_bile_salt0.94689814
109MP0002102_abnormal_ear_morphology0.92631513
110MP0004043_abnormal_pH_regulation0.91246895
111MP0004142_abnormal_muscle_tone0.90145964
112MP0005623_abnormal_meninges_morphology0.89987630
113MP0003123_paternal_imprinting0.88660708
114MP0002160_abnormal_reproductive_system0.88032108
115MP0004019_abnormal_vitamin_homeostasis0.87608620
116MP0005165_increased_susceptibility_to0.87573787
117MP0000427_abnormal_hair_cycle0.87353457
118MP0000462_abnormal_digestive_system0.85041981
119MP0002254_reproductive_system_inflammat0.82788309
120MP0005535_abnormal_body_temperature0.81422691
121MP0002971_abnormal_brown_adipose0.80495673
122MP0003045_fibrosis0.80261241
123MP0000538_abnormal_urinary_bladder0.78894248
124MP0002069_abnormal_eating/drinking_beha0.77146331
125MP0002078_abnormal_glucose_homeostasis0.76136587
126MP0004133_heterotaxia0.76059547
127* MP0005636_abnormal_mineral_homeostasis0.75852951
128MP0001879_abnormal_lymphatic_vessel0.72440137
129MP0009780_abnormal_chondrocyte_physiolo0.71862540
130MP0002108_abnormal_muscle_morphology0.70323743
131MP0005386_behavior/neurological_phenoty0.70308215
132MP0004924_abnormal_behavior0.70308215
133MP0008961_abnormal_basal_metabolism0.68475406
134MP0008569_lethality_at_weaning0.63936432
135MP0002128_abnormal_blood_circulation0.62246518
136* MP0001765_abnormal_ion_homeostasis0.61642445
137MP0005266_abnormal_metabolism0.61628624
138MP0004272_abnormal_basement_membrane0.55791545
139MP0005187_abnormal_penis_morphology0.55768116
140* MP0005319_abnormal_enzyme/_coenzyme0.55728868
141MP0003948_abnormal_gas_homeostasis0.55284738
142MP0003122_maternal_imprinting0.54675979
143MP0009046_muscle_twitch0.52861065
144MP0005334_abnormal_fat_pad0.49959440
145* MP0003953_abnormal_hormone_level0.49892272
146MP0005584_abnormal_enzyme/coenzyme_acti0.48220564
147MP0003566_abnormal_cell_adhesion0.46808238
148MP0006072_abnormal_retinal_apoptosis0.46458170
149MP0005595_abnormal_vascular_smooth0.45838268
150MP0002118_abnormal_lipid_homeostasis0.45251417
151MP0004147_increased_porphyrin_level0.44023550
152* MP0003635_abnormal_synaptic_transmissio0.43498814
153MP0005452_abnormal_adipose_tissue0.41691023
154MP0005448_abnormal_energy_balance0.41345004
155MP0000767_abnormal_smooth_muscle0.41316836
156MP0002090_abnormal_vision0.40587775
157MP0009115_abnormal_fat_cell0.40014626
158MP0001440_abnormal_grooming_behavior0.39501137
159MP0004859_abnormal_synaptic_plasticity0.39047084
160* MP0002272_abnormal_nervous_system0.37267478
161MP0009745_abnormal_behavioral_response0.37096752
162MP0002970_abnormal_white_adipose0.36202189
163MP0003705_abnormal_hypodermis_morpholog0.35986268
164MP0008438_abnormal_cutaneous_collagen0.34903357
165MP0002638_abnormal_pupillary_reflex0.33175292
166MP0002925_abnormal_cardiovascular_devel0.33033567
167MP0002064_seizures0.31883805
168MP0002067_abnormal_sensory_capabilities0.31722443
169MP0001529_abnormal_vocalization0.30834089

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.67258056
2Ventricular tachycardia (HP:0004756)6.24736402
3Atrial fibrillation (HP:0005110)6.10010315
4Primary atrial arrhythmia (HP:0001692)5.68711558
5Calf muscle hypertrophy (HP:0008981)5.49455394
6Supraventricular tachycardia (HP:0004755)5.48123279
7Supraventricular arrhythmia (HP:0005115)5.38204325
8Lipoatrophy (HP:0100578)4.96563258
9Exercise-induced myalgia (HP:0003738)4.94802359
10Muscle hypertrophy of the lower extremities (HP:0008968)4.87519186
11Syncope (HP:0001279)4.82942597
12Abnormality of the calf musculature (HP:0001430)4.65296325
13Myoglobinuria (HP:0002913)4.64946724
14Prolonged QT interval (HP:0001657)4.64570936
15Muscle fiber splitting (HP:0003555)4.59183243
16Exercise-induced muscle cramps (HP:0003710)4.58191486
17Bundle branch block (HP:0011710)4.57087471
18Palpitations (HP:0001962)4.48715474
19Subaortic stenosis (HP:0001682)4.41270338
20Abnormality of the left ventricular outflow tract (HP:0011103)4.41270338
21Hypoglycemic seizures (HP:0002173)4.40833292
22Right ventricular cardiomyopathy (HP:0011663)4.34974463
23Dilated cardiomyopathy (HP:0001644)4.14649803
24Hyporeflexia of lower limbs (HP:0002600)4.03929829
25Ventricular fibrillation (HP:0001663)3.88251369
26Heart block (HP:0012722)3.85947904
27Atrioventricular block (HP:0001678)3.85509135
28Ventricular arrhythmia (HP:0004308)3.80241323
29Abnormal atrioventricular conduction (HP:0005150)3.61351712
30Asymmetric septal hypertrophy (HP:0001670)3.57018670
31Hypoplasia of the uterus (HP:0000013)3.51441942
32Hyperglycemia (HP:0003074)3.50888619
33Aplasia/hypoplasia of the uterus (HP:0008684)3.47743180
34Hepatic necrosis (HP:0002605)3.45150487
35EMG: myopathic abnormalities (HP:0003458)3.41961709
36Abnormal EKG (HP:0003115)3.38753758
37Hypothermia (HP:0002045)3.36454039
38Rhabdomyolysis (HP:0003201)3.35329642
39Increased connective tissue (HP:0009025)3.26759511
40Abnormal mitochondria in muscle tissue (HP:0008316)3.22146601
41Abnormal pancreas size (HP:0012094)3.20153496
42Abnormality of the pancreatic islet cells (HP:0006476)3.18744384
43Abnormality of endocrine pancreas physiology (HP:0012093)3.18744384
44Myotonia (HP:0002486)3.17645509
45Ketoacidosis (HP:0001993)3.16871260
46Decreased circulating renin level (HP:0003351)3.14887975
47Acute necrotizing encephalopathy (HP:0006965)3.13695233
48Left ventricular hypertrophy (HP:0001712)3.10058761
49Difficulty running (HP:0009046)3.05638368
50Hepatocellular necrosis (HP:0001404)3.02962716
51Hyperventilation (HP:0002883)3.00449310
52Abnormal drinking behavior (HP:0030082)2.99668458
53Polydipsia (HP:0001959)2.99668458
54Increased muscle lipid content (HP:0009058)2.94753699
55Congenital sensorineural hearing impairment (HP:0008527)2.91067154
56Male pseudohermaphroditism (HP:0000037)2.90971973
57Hypoglycemic coma (HP:0001325)2.89350515
58Enlarged penis (HP:0000040)2.86818736
59Late onset (HP:0003584)2.83745558
60Hemiparesis (HP:0001269)2.83579302
61EEG with generalized epileptiform discharges (HP:0011198)2.81238893
62Epileptiform EEG discharges (HP:0011182)2.80456100
63Pheochromocytoma (HP:0002666)2.74119913
64Sex reversal (HP:0012245)2.73813274
65Abnormal sex determination (HP:0012244)2.73813274
66Acute encephalopathy (HP:0006846)2.73562409
67Congenital stationary night blindness (HP:0007642)2.70572659
68Mitochondrial inheritance (HP:0001427)2.68666623
69Hypsarrhythmia (HP:0002521)2.68496871
70Pancreatic cysts (HP:0001737)2.67882095
71Abnormality of fatty-acid metabolism (HP:0004359)2.67392098
72Symptomatic seizures (HP:0011145)2.65378522
73Abnormality of the renal cortex (HP:0011035)2.64551795
74Hypomagnesemia (HP:0002917)2.63685143
75Hypokalemic alkalosis (HP:0001949)2.62847458
76Progressive macrocephaly (HP:0004481)2.62267589
77Dicarboxylic aciduria (HP:0003215)2.57623917
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57623917
79Type II lissencephaly (HP:0007260)2.54575981
80Nephronophthisis (HP:0000090)2.53122165
81Agitation (HP:0000713)2.50800962
82Abnormality of midbrain morphology (HP:0002418)2.50480873
83Molar tooth sign on MRI (HP:0002419)2.50480873
84Increased CSF lactate (HP:0002490)2.50368398
85Dysmetric saccades (HP:0000641)2.49859211
86Febrile seizures (HP:0002373)2.49837806
87Hypokalemia (HP:0002900)2.44715624
88Gaze-evoked nystagmus (HP:0000640)2.41633083
89Neuroendocrine neoplasm (HP:0100634)2.40976835
90Ragged-red muscle fibers (HP:0003200)2.40072272
91Cerebral edema (HP:0002181)2.38842128
92Focal seizures (HP:0007359)2.36770067
93Increased variability in muscle fiber diameter (HP:0003557)2.35784372
94Conjunctival hamartoma (HP:0100780)2.35755579
95Testicular atrophy (HP:0000029)2.35310300
96Limb dystonia (HP:0002451)2.34891296
97Tubular atrophy (HP:0000092)2.33885707
98Abnormality of the renal medulla (HP:0100957)2.33470512
99Metaphyseal dysplasia (HP:0100255)2.30903007
100Lactic acidosis (HP:0003128)2.30784903
101Pancreatic fibrosis (HP:0100732)2.30658073
102Increased intramyocellular lipid droplets (HP:0012240)2.30542490
103Mesangial abnormality (HP:0001966)2.29163923
104Adrenal overactivity (HP:0002717)2.29096362
105Palmoplantar keratoderma (HP:0000982)2.27674222
106Difficulty climbing stairs (HP:0003551)2.23792860
107Ketosis (HP:0001946)2.23754435
108Respiratory failure (HP:0002878)2.20723618
109Polyuria (HP:0000103)2.20323384
110Abolished electroretinogram (ERG) (HP:0000550)2.20136278
111Neoplasm of the adrenal gland (HP:0100631)2.17765073
112Limb-girdle muscle atrophy (HP:0003797)2.17001878
113Muscle stiffness (HP:0003552)2.16253438
114Abnormality of calcium-phosphate metabolism (HP:0100530)2.15248991
115Insulin-resistant diabetes mellitus (HP:0000831)2.14951290
116Exercise intolerance (HP:0003546)2.13729594
117Intestinal atresia (HP:0011100)2.12848821
118Hamartoma of the eye (HP:0010568)2.12438079
119Testicular neoplasm (HP:0010788)2.12360731
120True hermaphroditism (HP:0010459)2.11099434
121Central scotoma (HP:0000603)2.10582451
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10166105
123Abnormality of alanine metabolism (HP:0010916)2.10166105
124Hyperalaninemia (HP:0003348)2.10166105
125Chronic hepatic failure (HP:0100626)2.09500723
126Large for gestational age (HP:0001520)2.09416228
127Attenuation of retinal blood vessels (HP:0007843)2.04888345
128Esophageal neoplasm (HP:0100751)2.01505890
129Neoplasm of head and neck (HP:0012288)2.01505890
130Absent speech (HP:0001344)2.00784443
131Hyperglycinuria (HP:0003108)1.99337816
132Medial flaring of the eyebrow (HP:0010747)1.99321074
133Progressive cerebellar ataxia (HP:0002073)1.98599550
134Renal salt wasting (HP:0000127)1.98165928
135Abnormality of renin-angiotensin system (HP:0000847)1.97610211
136Prominent metopic ridge (HP:0005487)1.97432710
137Hyperaldosteronism (HP:0000859)1.96595334
138Abnormality of skeletal muscle fiber size (HP:0012084)1.94305196
139Broad-based gait (HP:0002136)1.93786936
140Sudden cardiac death (HP:0001645)1.93390756
141Abnormality of the metopic suture (HP:0005556)1.92382763
142Hyperinsulinemic hypoglycemia (HP:0000825)1.92300417
143Dialeptic seizures (HP:0011146)1.90357118
144Abnormality of magnesium homeostasis (HP:0004921)1.90189065
145Lymphangioma (HP:0100764)1.90091338
146Abnormality of potassium homeostasis (HP:0011042)1.90046362
147Athetosis (HP:0002305)1.88284756
148Distal lower limb muscle weakness (HP:0009053)1.87961939
149Congestive heart failure (HP:0001635)1.87883199
150Focal motor seizures (HP:0011153)1.87795399
151Neck muscle weakness (HP:0000467)1.87448478
152Generalized aminoaciduria (HP:0002909)1.86828470
153Pancreatic islet-cell hyperplasia (HP:0004510)1.86620637
154Inability to walk (HP:0002540)1.86228137
155Neoplasm of the adrenal cortex (HP:0100641)1.85612647
156Abnormal urine output (HP:0012590)1.85153776
157Tinnitus (HP:0000360)1.83072160
158Tachypnea (HP:0002789)1.82409970
159Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82001077
160Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81777558
161Generalized tonic-clonic seizures (HP:0002069)1.81346594
162Progressive inability to walk (HP:0002505)1.80194023
163Widely spaced teeth (HP:0000687)1.80148715
164Muscular hypotonia of the trunk (HP:0008936)1.80115997
165Broad metatarsal (HP:0001783)1.79523288
166Bradycardia (HP:0001662)1.78448040
167Cystic liver disease (HP:0006706)1.76563628
168Abnormality of the foot musculature (HP:0001436)1.76523755
169Abnormal rod and cone electroretinograms (HP:0008323)1.75528263
170Polyphagia (HP:0002591)1.75219735
171Congenital malformation of the right heart (HP:0011723)1.74781200
172Double outlet right ventricle (HP:0001719)1.74781200
173Anxiety (HP:0000739)1.74757446
174Disproportionate short-trunk short stature (HP:0003521)1.74704304
175Epileptic encephalopathy (HP:0200134)1.73506507
176Gowers sign (HP:0003391)1.73051319
177Mildly elevated creatine phosphokinase (HP:0008180)1.71074231
178Abnormality of renal excretion (HP:0011036)1.71028990
179Increased circulating renin level (HP:0000848)1.69275967
180Hypoproteinemia (HP:0003075)1.68168237
181Hypoalbuminemia (HP:0003073)1.64751005
182Abnormal albumin level (HP:0012116)1.64751005
183Gait imbalance (HP:0002141)1.63210156
184Renal cortical cysts (HP:0000803)1.62312817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.69134128
2TTN4.60191694
3MYLK4.05429017
4LMTK24.04221911
5PHKG23.77970609
6PHKG13.77970609
7PDK33.41328711
8PDK43.41328711
9TRIB33.37224309
10BCKDK2.91638773
11OBSCN2.78632099
12PKN22.73022354
13DMPK2.65403386
14ADRBK22.46669386
15MAP4K22.46040250
16CASK2.46023400
17DAPK22.40405557
18PINK12.19617610
19MUSK2.18829836
20FGFR22.15787381
21PIK3CA2.11114209
22TIE12.10744879
23WNK32.08996886
24PDK22.07218861
25GRK11.90380133
26EPHA41.88143792
27MARK11.80312691
28NEK11.70535778
29AKT31.69005556
30BMPR1B1.68291162
31STK241.64316116
32PAK31.62225619
33NLK1.61655413
34TNIK1.56099007
35MAPK131.43481878
36RIPK11.42619854
37GRK71.41868012
38CAMK2D1.40727460
39INSRR1.35812297
40PRKD11.34704958
41OXSR11.33815523
42WNK41.29988458
43MAP2K61.23906743
44CDC42BPA1.23305638
45EPHA31.21769204
46PRKCG1.19412524
47ILK1.14360184
48TAOK31.11950986
49ACVR1B1.11652103
50PLK21.04520221
51TLK11.02958596
52STK381.01379978
53PDGFRA1.00981760
54ROCK10.97217214
55ADRBK10.97091566
56MAPK120.96666891
57WNK10.95598582
58MAP3K20.95561136
59MST40.94386441
60NTRK20.94271142
61CSNK1G10.93725156
62MAP2K70.92748811
63PRKAA10.91492786
64CSNK1G20.85093107
65STK38L0.83352265
66CAMK10.83304272
67CAMK40.83131746
68MAP3K70.83009169
69CSNK1G30.81812106
70PRKAA20.81363824
71PKN10.81199770
72DYRK20.80550644
73SIK10.80394332
74DAPK30.78433614
75MAP3K40.76260741
76CAMK2A0.75600146
77STK390.73309395
78FGFR30.72757862
79PRKD30.72150599
80IRAK10.71317768
81PRKCE0.70018771
82PASK0.68664020
83NUAK10.67392052
84PRKCH0.67242186
85STK30.67081606
86CAMK1G0.66305229
87PAK60.66167588
88PRKCZ0.65718344
89PDPK10.64853066
90ROCK20.64586338
91EIF2AK30.64201088
92HIPK20.63428027
93PNCK0.61910491
94RPS6KL10.61505673
95RPS6KC10.61505673
96ICK0.60786588
97CAMK1D0.60592920
98DDR20.59854025
99EPHB20.58617600
100MAPKAPK30.57033371
101CDK50.56404767
102CSNK1A1L0.55930143
103PRKACB0.55496239
104PRKCI0.55445636
105PTK2B0.55340854
106MAP3K50.54071234
107FER0.54007923
108PRKACG0.53747097
109ZAK0.52681916
110ERBB30.51972062
111FLT30.51721153
112RPS6KA60.51270615
113* PRKACA0.50579919
114TGFBR20.50307097
115CSNK1A10.49862420
116ERN10.49839290
117MAPK150.49670522
118SGK30.49147056
119PDK10.47802098
120TRIM280.47705165
121STK40.47415603
122MAP2K40.45363878
123CAMK2G0.44600643
124MAP3K90.43044725
125PRKCA0.41300462
126TRPM70.40461981
127PTK60.40268209
128RET0.38514887
129KDR0.37966289
130MAPKAPK50.37687686
131TNK20.37053352
132NTRK30.36407752
133CAMKK10.36056274
134PRKG20.34006769
135CAMKK20.33959692
136UHMK10.31803145
137LATS20.31283979
138RPS6KA20.30280874
139MAP2K10.30174274
140MAP2K20.29734498
141SGK20.29237918
142CSNK1D0.29009627
143SGK4940.27635476
144SGK2230.27635476
145CAMK2B0.26654582
146SGK10.26147268
147EPHB10.24097145
148MARK20.23184230
149MAP3K30.22792121
150PRKG10.22656467
151* RPS6KA30.22610778
152GRK50.21702864
153MAP3K10.20237121
154JAK10.19664007
155STK110.19100577
156RPS6KA10.19039602

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.71796984
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.46716300
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.87628582
4Cardiac muscle contraction_Homo sapiens_hsa042603.73613280
5Propanoate metabolism_Homo sapiens_hsa006403.29297285
6Dilated cardiomyopathy_Homo sapiens_hsa054143.06269805
7Oxidative phosphorylation_Homo sapiens_hsa001902.95143493
8Parkinsons disease_Homo sapiens_hsa050122.87915547
9Fatty acid degradation_Homo sapiens_hsa000712.80473814
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.77373541
11Fatty acid metabolism_Homo sapiens_hsa012122.54820622
12Vitamin B6 metabolism_Homo sapiens_hsa007502.48338814
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42990464
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31630429
15Carbon metabolism_Homo sapiens_hsa012002.23104023
16Alzheimers disease_Homo sapiens_hsa050102.21668838
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10677957
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94892401
19Phototransduction_Homo sapiens_hsa047441.86006709
20Pyruvate metabolism_Homo sapiens_hsa006201.85495371
21Sulfur metabolism_Homo sapiens_hsa009201.82644726
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81920334
23Huntingtons disease_Homo sapiens_hsa050161.78609374
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74173690
25* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62231684
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55886838
27Steroid biosynthesis_Homo sapiens_hsa001001.49191778
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46294519
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44186091
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43973744
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39556855
32Butanoate metabolism_Homo sapiens_hsa006501.39182868
33PPAR signaling pathway_Homo sapiens_hsa033201.38321494
34Collecting duct acid secretion_Homo sapiens_hsa049661.38194257
35Fatty acid elongation_Homo sapiens_hsa000621.37575183
36Selenocompound metabolism_Homo sapiens_hsa004501.36956142
37Ovarian steroidogenesis_Homo sapiens_hsa049131.36014135
38ABC transporters_Homo sapiens_hsa020101.34097966
39Linoleic acid metabolism_Homo sapiens_hsa005911.27326591
40Ether lipid metabolism_Homo sapiens_hsa005651.22616644
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21180336
42Protein export_Homo sapiens_hsa030601.20641791
43Nitrogen metabolism_Homo sapiens_hsa009101.19150990
44Fatty acid biosynthesis_Homo sapiens_hsa000611.18477041
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14823210
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11095722
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10088163
48Regulation of autophagy_Homo sapiens_hsa041401.05675339
49Renin secretion_Homo sapiens_hsa049241.03754636
50Viral myocarditis_Homo sapiens_hsa054161.00082753
51Glucagon signaling pathway_Homo sapiens_hsa049220.97190868
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94734245
53Circadian entrainment_Homo sapiens_hsa047130.94655809
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.94634008
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94432011
56Insulin secretion_Homo sapiens_hsa049110.91442346
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90813729
58Mineral absorption_Homo sapiens_hsa049780.90250391
59Insulin resistance_Homo sapiens_hsa049310.89782239
60Calcium signaling pathway_Homo sapiens_hsa040200.89426481
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87940978
62Type II diabetes mellitus_Homo sapiens_hsa049300.87606210
63Protein digestion and absorption_Homo sapiens_hsa049740.86593620
64Sphingolipid metabolism_Homo sapiens_hsa006000.84639319
65cAMP signaling pathway_Homo sapiens_hsa040240.81780210
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81272248
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80259986
68Insulin signaling pathway_Homo sapiens_hsa049100.80153166
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78727372
70Biosynthesis of amino acids_Homo sapiens_hsa012300.77760736
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.77524686
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76499668
73Oxytocin signaling pathway_Homo sapiens_hsa049210.75929189
74Long-term depression_Homo sapiens_hsa047300.75921382
75Thyroid hormone synthesis_Homo sapiens_hsa049180.75751696
76Caffeine metabolism_Homo sapiens_hsa002320.75470938
77beta-Alanine metabolism_Homo sapiens_hsa004100.72574633
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71585444
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69887494
80Type I diabetes mellitus_Homo sapiens_hsa049400.69542902
81Gastric acid secretion_Homo sapiens_hsa049710.69221738
82AMPK signaling pathway_Homo sapiens_hsa041520.67833486
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.66864732
84Morphine addiction_Homo sapiens_hsa050320.66780173
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65467982
86Chemical carcinogenesis_Homo sapiens_hsa052040.65307931
87Lysine degradation_Homo sapiens_hsa003100.64296278
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64208396
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63902221
90Vitamin digestion and absorption_Homo sapiens_hsa049770.63733180
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62548910
92Salivary secretion_Homo sapiens_hsa049700.61102028
93Taste transduction_Homo sapiens_hsa047420.61019242
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.60107112
95Vibrio cholerae infection_Homo sapiens_hsa051100.59931968
96Tryptophan metabolism_Homo sapiens_hsa003800.59128809
97Histidine metabolism_Homo sapiens_hsa003400.58980284
98Tyrosine metabolism_Homo sapiens_hsa003500.58802326
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57932883
100GABAergic synapse_Homo sapiens_hsa047270.57740947
101Retinol metabolism_Homo sapiens_hsa008300.55819339
102Olfactory transduction_Homo sapiens_hsa047400.50660753
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50189186
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48571373
105Cholinergic synapse_Homo sapiens_hsa047250.48443346
106Focal adhesion_Homo sapiens_hsa045100.48101204
107Starch and sucrose metabolism_Homo sapiens_hsa005000.47330913
108HIF-1 signaling pathway_Homo sapiens_hsa040660.46477935
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46225305
110Glutamatergic synapse_Homo sapiens_hsa047240.45446632
111Arachidonic acid metabolism_Homo sapiens_hsa005900.45283075
112Folate biosynthesis_Homo sapiens_hsa007900.45031890
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.41900879
114Glycerolipid metabolism_Homo sapiens_hsa005610.41560972
115Dopaminergic synapse_Homo sapiens_hsa047280.40604358
116Gap junction_Homo sapiens_hsa045400.39613682
117Peroxisome_Homo sapiens_hsa041460.38749026
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38578523
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38545004
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38514059
121Long-term potentiation_Homo sapiens_hsa047200.38065030
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.37642983
123Fat digestion and absorption_Homo sapiens_hsa049750.37333471
124Circadian rhythm_Homo sapiens_hsa047100.35904927
125Amphetamine addiction_Homo sapiens_hsa050310.35514465
126Arginine biosynthesis_Homo sapiens_hsa002200.35307980
127GnRH signaling pathway_Homo sapiens_hsa049120.34966877
128Pancreatic secretion_Homo sapiens_hsa049720.34628451
129Bile secretion_Homo sapiens_hsa049760.33812319
130Fructose and mannose metabolism_Homo sapiens_hsa000510.32711477
131Synaptic vesicle cycle_Homo sapiens_hsa047210.32604259
132Phenylalanine metabolism_Homo sapiens_hsa003600.32389179
133Estrogen signaling pathway_Homo sapiens_hsa049150.31622207
134Nicotine addiction_Homo sapiens_hsa050330.31160287
135Galactose metabolism_Homo sapiens_hsa000520.30000407
136ECM-receptor interaction_Homo sapiens_hsa045120.29851942
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27176828
138Tight junction_Homo sapiens_hsa045300.23893787
139Metabolic pathways_Homo sapiens_hsa011000.23361198
140Serotonergic synapse_Homo sapiens_hsa047260.21017168
141Arginine and proline metabolism_Homo sapiens_hsa003300.20396531
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.19011218
143Renal cell carcinoma_Homo sapiens_hsa052110.18625699
144Cocaine addiction_Homo sapiens_hsa050300.17559899
145Amoebiasis_Homo sapiens_hsa051460.16579876
146Dorso-ventral axis formation_Homo sapiens_hsa043200.14598942

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