KCNK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.15110863
2glutamate secretion (GO:0014047)6.93573352
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.65835926
4synaptic vesicle exocytosis (GO:0016079)6.40046241
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.22782589
6regulation of synaptic vesicle exocytosis (GO:2000300)5.97183261
7synaptic vesicle maturation (GO:0016188)5.95985922
8vocalization behavior (GO:0071625)5.94122310
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91117751
10neuronal action potential propagation (GO:0019227)5.50255741
11regulation of glutamate receptor signaling pathway (GO:1900449)5.49966758
12protein localization to synapse (GO:0035418)5.33104509
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.29124923
14neurotransmitter-gated ion channel clustering (GO:0072578)5.17611358
15regulation of synaptic vesicle transport (GO:1902803)5.15323583
16neuron cell-cell adhesion (GO:0007158)5.07933830
17locomotory exploration behavior (GO:0035641)5.03711326
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94494449
19L-amino acid import (GO:0043092)4.87236467
20neurotransmitter secretion (GO:0007269)4.73809705
21sodium ion export (GO:0071436)4.73184872
22positive regulation of synapse maturation (GO:0090129)4.72111623
23presynaptic membrane assembly (GO:0097105)4.59329003
24proline transport (GO:0015824)4.43252894
25negative regulation of dendrite morphogenesis (GO:0050774)4.41016491
26regulation of neuronal synaptic plasticity (GO:0048168)4.34264026
27amino acid import (GO:0043090)4.32065067
28presynaptic membrane organization (GO:0097090)4.30394233
29synaptic transmission, glutamatergic (GO:0035249)4.28645868
30postsynaptic membrane organization (GO:0001941)4.27790481
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.27187034
32ionotropic glutamate receptor signaling pathway (GO:0035235)4.26417013
33positive regulation of dendritic spine development (GO:0060999)4.21821816
34positive regulation of neurotransmitter secretion (GO:0001956)4.16769126
35neuron-neuron synaptic transmission (GO:0007270)4.15440753
36exploration behavior (GO:0035640)4.06970462
37regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04458273
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03942492
39positive regulation of membrane potential (GO:0045838)4.00678158
40regulation of neurotransmitter secretion (GO:0046928)3.96918083
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93722727
42glutamate receptor signaling pathway (GO:0007215)3.92674903
43regulation of postsynaptic membrane potential (GO:0060078)3.85863354
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.83294653
45regulation of synaptic plasticity (GO:0048167)3.82549557
46cerebellar granule cell differentiation (GO:0021707)3.82002965
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.81447242
48neurotransmitter transport (GO:0006836)3.75519215
49axon ensheathment in central nervous system (GO:0032291)3.75150650
50central nervous system myelination (GO:0022010)3.75150650
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73260885
52regulation of synapse maturation (GO:0090128)3.71114927
53long-term synaptic potentiation (GO:0060291)3.69282630
54positive regulation of neurotransmitter transport (GO:0051590)3.65913066
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.65827393
56potassium ion homeostasis (GO:0055075)3.65257444
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.59085245
58neuromuscular synaptic transmission (GO:0007274)3.59069990
59layer formation in cerebral cortex (GO:0021819)3.58466275
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58012468
61dendritic spine organization (GO:0097061)3.57559449
62neuronal ion channel clustering (GO:0045161)3.56726776
63regulation of ARF protein signal transduction (GO:0032012)3.56703876
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.54859483
65cerebellar Purkinje cell differentiation (GO:0021702)3.52044158
66synaptic vesicle endocytosis (GO:0048488)3.51996715
67regulation of neurotransmitter transport (GO:0051588)3.51908001
68long-term memory (GO:0007616)3.49180466
69transferrin transport (GO:0033572)3.48826028
70negative regulation of dendrite development (GO:2000171)3.48823327
71regulation of neurotransmitter levels (GO:0001505)3.48414762
72ATP hydrolysis coupled proton transport (GO:0015991)3.47452352
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.47452352
74potassium ion import (GO:0010107)3.46159269
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.45029425
76regulation of dendritic spine morphogenesis (GO:0061001)3.43194264
77regulation of vesicle fusion (GO:0031338)3.41859630
78activation of protein kinase A activity (GO:0034199)3.41378491
79regulation of synapse structural plasticity (GO:0051823)3.35907399
80cellular potassium ion homeostasis (GO:0030007)3.31493292
81cell communication by electrical coupling (GO:0010644)3.28581541
82membrane depolarization (GO:0051899)3.27403076
83response to histamine (GO:0034776)3.26574843
84neuromuscular process controlling posture (GO:0050884)3.25781069
85auditory behavior (GO:0031223)3.25230783
86regulation of voltage-gated calcium channel activity (GO:1901385)3.24821976
87mechanosensory behavior (GO:0007638)3.23737826
88transmission of nerve impulse (GO:0019226)3.22506154
89calcium ion-dependent exocytosis (GO:0017156)3.22167050
90acidic amino acid transport (GO:0015800)3.21463554
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21407541
92trivalent inorganic cation transport (GO:0072512)3.21387992
93ferric iron transport (GO:0015682)3.21387992
94neuron recognition (GO:0008038)3.21228878
95neuromuscular process controlling balance (GO:0050885)3.19838844
96cell migration in hindbrain (GO:0021535)3.18382275
97membrane depolarization during action potential (GO:0086010)3.18080083
98positive regulation of synaptic transmission (GO:0050806)3.17204252
99regulation of dendritic spine development (GO:0060998)3.16355276
100phosphorelay signal transduction system (GO:0000160)3.15887909
101sleep (GO:0030431)3.14098723
102regulation of synaptic transmission (GO:0050804)3.13481631
103chemosensory behavior (GO:0007635)3.12320890
104regulation of glutamate secretion (GO:0014048)3.11492650
105cytoskeletal anchoring at plasma membrane (GO:0007016)3.10923404
106gamma-aminobutyric acid transport (GO:0015812)3.10468277
107response to auditory stimulus (GO:0010996)3.09178516
108* synaptic transmission (GO:0007268)3.08556968
109dendritic spine morphogenesis (GO:0060997)3.07952183
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05807757
111cellular sodium ion homeostasis (GO:0006883)3.05476661
112dicarboxylic acid transport (GO:0006835)3.03471785
113innervation (GO:0060384)3.03097842
114long term synaptic depression (GO:0060292)3.02598906
115regulation of exocytosis (GO:0017157)3.01555428
116neuromuscular process (GO:0050905)3.00153616
117vesicle docking involved in exocytosis (GO:0006904)2.99719367
118acid secretion (GO:0046717)2.99210165
119establishment of synaptic vesicle localization (GO:0097480)2.98453538
120synaptic vesicle transport (GO:0048489)2.98453538
121response to gravity (GO:0009629)2.98383627
122neurotransmitter uptake (GO:0001504)2.96539483
123behavioral response to cocaine (GO:0048148)2.95950677
124regulation of sodium ion transmembrane transporter activity (GO:2000649)2.95157185
125synapse assembly (GO:0007416)2.90090565
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87907871
127learning (GO:0007612)2.85763327
128axonal fasciculation (GO:0007413)2.85545170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.25504654
2GBX2_23144817_ChIP-Seq_PC3_Human4.16953591
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.42643654
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17787456
5REST_21632747_ChIP-Seq_MESCs_Mouse3.16212091
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13203142
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.79571893
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78054479
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78054479
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71127091
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68808875
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61478414
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.61122436
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60904647
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59487685
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59435948
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59050632
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.44287367
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.33101935
20DROSHA_22980978_ChIP-Seq_HELA_Human2.31644948
21TAF15_26573619_Chip-Seq_HEK293_Human2.28893101
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26461705
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.19756768
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18618928
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17464022
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11049891
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99595520
28* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99520018
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99259564
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95476410
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79985299
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.77315558
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73281212
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.72519453
35AR_21572438_ChIP-Seq_LNCaP_Human1.71363607
36SMAD4_21799915_ChIP-Seq_A2780_Human1.70045986
37CTCF_27219007_Chip-Seq_Bcells_Human1.69987683
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67537841
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62234948
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57702903
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55770736
42LXR_22292898_ChIP-Seq_THP-1_Human1.50793973
43P300_19829295_ChIP-Seq_ESCs_Human1.49044938
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44735285
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43990378
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40933496
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.40511759
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38016021
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.36706756
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35864931
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35208246
52AR_25329375_ChIP-Seq_VCAP_Human1.31189721
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30359376
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29858816
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27666319
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24908038
57P68_20966046_ChIP-Seq_HELA_Human1.23349803
58VDR_22108803_ChIP-Seq_LS180_Human1.23272396
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.22647774
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22208315
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22097941
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21524012
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20811835
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19751134
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19302902
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17495070
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.15436935
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14067193
69ZNF274_21170338_ChIP-Seq_K562_Hela1.13553784
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13159953
71SMC4_20622854_ChIP-Seq_HELA_Human1.12859944
72AR_19668381_ChIP-Seq_PC3_Human1.12519138
73OCT4_19829295_ChIP-Seq_ESCs_Human1.11544313
74STAT3_23295773_ChIP-Seq_U87_Human1.11329328
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08531653
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08427454
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07944962
78* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07515158
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.06824264
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06225929
81CREB1_26743006_Chip-Seq_LNCaP_Human1.06025226
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04810794
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.04668141
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04041328
85FUS_26573619_Chip-Seq_HEK293_Human1.03918401
86RNF2_27304074_Chip-Seq_NSC_Mouse1.03162468
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02715355
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02433657
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.02343742
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.01423964
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.00944263
92JUN_21703547_ChIP-Seq_K562_Human1.00603452
93TCF4_23295773_ChIP-Seq_U87_Human1.00388809
94RXR_22108803_ChIP-Seq_LS180_Human0.98680639
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98097131
96AHR_22903824_ChIP-Seq_MCF-7_Human0.97541555
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97473823
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97249679
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95751756
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.95483133
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95193833
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94712697
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94465870
104DPY_21335234_ChIP-Seq_ESCs_Mouse0.94349151
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93670895
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93168680
107KLF4_19829295_ChIP-Seq_ESCs_Human0.93149237
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92627286
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.90991396
110TP53_16413492_ChIP-PET_HCT116_Human0.89316588
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89248738
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88876339
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.88482717
114* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87254323
115KDM2B_26808549_Chip-Seq_K562_Human0.87078643
116SOX9_26525672_Chip-Seq_HEART_Mouse0.87028090
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86255489
118* TET1_21451524_ChIP-Seq_MESCs_Mouse0.86029600
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85478851
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85282358
121KDM2B_26808549_Chip-Seq_DND41_Human0.85159053
122TP53_18474530_ChIP-ChIP_U2OS_Human0.84428056
123RUNX2_22187159_ChIP-Seq_PCA_Human0.84197019
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83847558
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83331686
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83225494
127CTCF_20526341_ChIP-Seq_ESCs_Human0.81713081
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.81699458
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81021654
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80478684
131SA1_27219007_Chip-Seq_Bcells_Human0.79729027
132ER_23166858_ChIP-Seq_MCF-7_Human0.79613711
133EGR1_19032775_ChIP-ChIP_M12_Human0.78736896
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.78582174
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78179896
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76717710
137MYC_19915707_ChIP-ChIP_AK7_Human0.76481815
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.75547858
139SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.74917666
140SMAD4_21741376_ChIP-Seq_ESCs_Human0.74022659
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72841777
142* TP53_23651856_ChIP-Seq_MEFs_Mouse0.72561895
143TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71073578
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.71069359
145* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70998163
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69943064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.55569916
2MP0003880_abnormal_central_pattern5.39179099
3MP0004270_analgesia4.28034689
4MP0003635_abnormal_synaptic_transmissio4.17608921
5MP0001968_abnormal_touch/_nociception3.56611439
6MP0009745_abnormal_behavioral_response3.52588556
7MP0009046_muscle_twitch3.45723128
8MP0002063_abnormal_learning/memory/cond3.37458332
9MP0002064_seizures3.35563792
10MP0002736_abnormal_nociception_after3.03470280
11MP0002735_abnormal_chemical_nociception2.93936877
12MP0002572_abnormal_emotion/affect_behav2.86783201
13MP0002734_abnormal_mechanical_nocicepti2.84666985
14MP0002272_abnormal_nervous_system2.59657834
15MP0001486_abnormal_startle_reflex2.44605399
16MP0009780_abnormal_chondrocyte_physiolo2.36650718
17MP0001501_abnormal_sleep_pattern2.32534641
18MP0004858_abnormal_nervous_system2.32043251
19MP0001440_abnormal_grooming_behavior2.31430242
20MP0002733_abnormal_thermal_nociception2.18060340
21MP0002067_abnormal_sensory_capabilities2.13752188
22MP0002822_catalepsy2.12804466
23MP0001970_abnormal_pain_threshold2.12453391
24MP0003879_abnormal_hair_cell2.10638648
25MP0003329_amyloid_beta_deposits2.01405774
26MP0006276_abnormal_autonomic_nervous1.98518345
27MP0005423_abnormal_somatic_nervous1.86736760
28MP0004811_abnormal_neuron_physiology1.83115308
29MP0008569_lethality_at_weaning1.82464963
30MP0002184_abnormal_innervation1.80251797
31MP0005386_behavior/neurological_phenoty1.61759504
32MP0004924_abnormal_behavior1.61759504
33MP0002557_abnormal_social/conspecific_i1.57003181
34MP0003787_abnormal_imprinting1.55946670
35MP0000778_abnormal_nervous_system1.53655744
36MP0000920_abnormal_myelination1.45639202
37MP0003633_abnormal_nervous_system1.42806901
38MP0000955_abnormal_spinal_cord1.42228791
39MP0002066_abnormal_motor_capabilities/c1.41199959
40MP0005646_abnormal_pituitary_gland1.40699270
41MP0002909_abnormal_adrenal_gland1.35679412
42MP0002882_abnormal_neuron_morphology1.29410358
43MP0001984_abnormal_olfaction1.29226079
44MP0002638_abnormal_pupillary_reflex1.23352953
45MP0004142_abnormal_muscle_tone1.21499591
46MP0008872_abnormal_physiological_respon1.20172407
47MP0000751_myopathy1.19786572
48MP0001905_abnormal_dopamine_level1.19656666
49MP0003631_nervous_system_phenotype1.18080295
50MP0005167_abnormal_blood-brain_barrier1.17303257
51MP0001502_abnormal_circadian_rhythm1.13428296
52MP0001529_abnormal_vocalization1.11040479
53MP0002837_dystrophic_cardiac_calcinosis1.09498991
54MP0003122_maternal_imprinting1.07920203
55MP0001986_abnormal_taste_sensitivity1.07191344
56MP0004885_abnormal_endolymph1.07033397
57MP0008874_decreased_physiological_sensi1.05301142
58MP0000604_amyloidosis0.96378185
59MP0003283_abnormal_digestive_organ0.94633558
60MP0010386_abnormal_urinary_bladder0.93862943
61MP0002876_abnormal_thyroid_physiology0.93656798
62MP0004742_abnormal_vestibular_system0.93373355
63MP0002152_abnormal_brain_morphology0.92964055
64MP0004233_abnormal_muscle_weight0.89511569
65MP0005535_abnormal_body_temperature0.89412997
66MP0003172_abnormal_lysosome_physiology0.87302399
67MP0001963_abnormal_hearing_physiology0.86412644
68MP0004145_abnormal_muscle_electrophysio0.86169766
69MP0002229_neurodegeneration0.85905943
70MP0002069_abnormal_eating/drinking_beha0.85098111
71MP0001485_abnormal_pinna_reflex0.85053342
72MP0004510_myositis0.84573159
73MP0004484_altered_response_of0.84408209
74MP0003075_altered_response_to0.81377817
75MP0002089_abnormal_postnatal_growth/wei0.80483589
76MP0005623_abnormal_meninges_morphology0.78439373
77MP0001188_hyperpigmentation0.76708127
78MP0004085_abnormal_heartbeat0.76449481
79MP0000013_abnormal_adipose_tissue0.73895991
80MP0003646_muscle_fatigue0.72144464
81MP0001346_abnormal_lacrimal_gland0.70759296
82MP0000026_abnormal_inner_ear0.69761738
83MP0005645_abnormal_hypothalamus_physiol0.68981324
84MP0003632_abnormal_nervous_system0.68376644
85MP0003634_abnormal_glial_cell0.68298007
86MP0003183_abnormal_peptide_metabolism0.66745676
87MP0005394_taste/olfaction_phenotype0.66121804
88MP0005499_abnormal_olfactory_system0.66121804
89MP0004043_abnormal_pH_regulation0.65259761
90MP0000579_abnormal_nail_morphology0.65000069
91MP0003123_paternal_imprinting0.64997179
92MP0005171_absent_coat_pigmentation0.63693043
93MP0005187_abnormal_penis_morphology0.63229871
94MP0008260_abnormal_autophagy0.62833107
95MP0002653_abnormal_ependyma_morphology0.61203431
96MP0003045_fibrosis0.61180804
97MP0002752_abnormal_somatic_nervous0.60917086
98MP0000569_abnormal_digit_pigmentation0.60574413
99MP0004215_abnormal_myocardial_fiber0.59285898
100MP0001664_abnormal_digestion0.59013109
101MP0003690_abnormal_glial_cell0.57191094
102MP0002249_abnormal_larynx_morphology0.57033038
103MP0000566_synostosis0.56421507
104MP0004147_increased_porphyrin_level0.56244348
105MP0008877_abnormal_DNA_methylation0.55921419
106MP0005166_decreased_susceptibility_to0.54763202
107MP0002090_abnormal_vision0.53433437
108MP0003137_abnormal_impulse_conducting0.53044035
109MP0005377_hearing/vestibular/ear_phenot0.52649589
110MP0003878_abnormal_ear_physiology0.52649589
111MP0001348_abnormal_lacrimal_gland0.51748997
112MP0005551_abnormal_eye_electrophysiolog0.51634793
113MP0010769_abnormal_survival0.51475925
114MP0001177_atelectasis0.51021294
115MP0003938_abnormal_ear_development0.49835132
116MP0001943_abnormal_respiration0.49790611
117MP0004130_abnormal_muscle_cell0.49657961
118MP0001765_abnormal_ion_homeostasis0.49638440
119MP0002082_postnatal_lethality0.49363501
120MP0010770_preweaning_lethality0.49363501
121MP0010768_mortality/aging0.48619403
122MP0003956_abnormal_body_size0.47569099

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.32971992
2Myokymia (HP:0002411)6.97640473
3Epileptic encephalopathy (HP:0200134)6.52163692
4Atonic seizures (HP:0010819)6.26962115
5Focal seizures (HP:0007359)6.15583455
6Febrile seizures (HP:0002373)5.21712733
7Visual hallucinations (HP:0002367)5.13194897
8Absence seizures (HP:0002121)4.92471088
9Dialeptic seizures (HP:0011146)4.61557725
10Hyperventilation (HP:0002883)4.58953357
11Generalized tonic-clonic seizures (HP:0002069)4.29774697
12Broad-based gait (HP:0002136)3.93295921
13Progressive cerebellar ataxia (HP:0002073)3.92644046
14Neurofibrillary tangles (HP:0002185)3.76857602
15Action tremor (HP:0002345)3.72258063
16Poor eye contact (HP:0000817)3.59044631
17Gaze-evoked nystagmus (HP:0000640)3.57683185
18Amblyopia (HP:0000646)3.49752904
19Obstructive sleep apnea (HP:0002870)3.29139499
20Abnormal eating behavior (HP:0100738)3.29059881
21Dysmetric saccades (HP:0000641)3.27337991
22Impaired vibration sensation in the lower limbs (HP:0002166)3.23202593
23Urinary bladder sphincter dysfunction (HP:0002839)3.20969551
24Tetraplegia (HP:0002445)3.20280919
25Cerebral hypomyelination (HP:0006808)3.19207637
26Impaired social interactions (HP:0000735)3.18241925
27Abnormal social behavior (HP:0012433)3.18241925
28Ankle clonus (HP:0011448)3.16354819
29Limb dystonia (HP:0002451)3.11368515
30Truncal ataxia (HP:0002078)3.00349722
31Abnormality of the lower motor neuron (HP:0002366)2.92330341
32Neuronal loss in central nervous system (HP:0002529)2.90987545
33Supranuclear gaze palsy (HP:0000605)2.90439788
34Depression (HP:0000716)2.86118290
35Clonus (HP:0002169)2.84850077
36Intention tremor (HP:0002080)2.84649819
37Urinary urgency (HP:0000012)2.84040836
38Delusions (HP:0000746)2.82188180
39Termporal pattern (HP:0011008)2.79463698
40Insidious onset (HP:0003587)2.79463698
41Epileptiform EEG discharges (HP:0011182)2.77803087
42Dysdiadochokinesis (HP:0002075)2.77744514
43Impaired smooth pursuit (HP:0007772)2.76511297
44Excessive salivation (HP:0003781)2.73965352
45Drooling (HP:0002307)2.73965352
46Pheochromocytoma (HP:0002666)2.72587441
47Status epilepticus (HP:0002133)2.72234437
48Fetal akinesia sequence (HP:0001989)2.70675082
49Spastic tetraparesis (HP:0001285)2.66195407
50Polyphagia (HP:0002591)2.60341214
51Peripheral hypomyelination (HP:0007182)2.57965515
52Anxiety (HP:0000739)2.57867524
53Dysmetria (HP:0001310)2.57636204
54Ventricular fibrillation (HP:0001663)2.55634476
55Inability to walk (HP:0002540)2.53548830
56Apathy (HP:0000741)2.51224328
57Stereotypic behavior (HP:0000733)2.50527923
58Mutism (HP:0002300)2.49937149
59Impaired vibratory sensation (HP:0002495)2.49813485
60Neuroendocrine neoplasm (HP:0100634)2.49285039
61EEG with generalized epileptiform discharges (HP:0011198)2.48643154
62Torticollis (HP:0000473)2.44466003
63Insomnia (HP:0100785)2.42793196
64Spastic gait (HP:0002064)2.42714185
65Postural instability (HP:0002172)2.41286080
66Focal dystonia (HP:0004373)2.36997830
67Bradykinesia (HP:0002067)2.36169122
68Hypsarrhythmia (HP:0002521)2.34585366
69Abnormality of the labia minora (HP:0012880)2.34443814
70Bundle branch block (HP:0011710)2.27254757
71Genetic anticipation (HP:0003743)2.25923316
72Turricephaly (HP:0000262)2.25120805
73Aplasia involving bones of the upper limbs (HP:0009823)2.23990472
74Aplasia of the phalanges of the hand (HP:0009802)2.23990472
75Aplasia involving bones of the extremities (HP:0009825)2.23990472
76Abnormality of ocular smooth pursuit (HP:0000617)2.23155343
77Rigidity (HP:0002063)2.23110784
78Diminished motivation (HP:0000745)2.22855648
79Abnormal hair whorl (HP:0010721)2.21027993
80Protruding tongue (HP:0010808)2.16631594
81Progressive inability to walk (HP:0002505)2.16163907
82Bronchomalacia (HP:0002780)2.15391839
83Hemiparesis (HP:0001269)2.14296093
84Cerebral inclusion bodies (HP:0100314)2.12249870
85Poor suck (HP:0002033)2.11203879
86Failure to thrive in infancy (HP:0001531)2.10798773
87Abnormality of the corticospinal tract (HP:0002492)2.09786989
88CNS hypomyelination (HP:0003429)2.07792591
89Scanning speech (HP:0002168)2.07745347
90Megalencephaly (HP:0001355)2.07544575
91Abnormality of pain sensation (HP:0010832)2.05338593
92Impaired pain sensation (HP:0007328)2.05338593
93Diplopia (HP:0000651)2.03511705
94Abnormality of binocular vision (HP:0011514)2.03511705
95Incomplete penetrance (HP:0003829)2.03412498
96Craniofacial dystonia (HP:0012179)2.02973121
97Lower limb muscle weakness (HP:0007340)2.02644429
98Generalized myoclonic seizures (HP:0002123)2.02443356
99Annular pancreas (HP:0001734)2.02284116
100Absent speech (HP:0001344)2.02089205
101Oligomenorrhea (HP:0000876)1.97933036
102Specific learning disability (HP:0001328)1.96185598
103Gait imbalance (HP:0002141)1.93788452
104Morphological abnormality of the pyramidal tract (HP:0002062)1.91270886
105Heart block (HP:0012722)1.90840162
106Large eyes (HP:0001090)1.90564903
107Akinesia (HP:0002304)1.90511523
108Short chin (HP:0000331)1.90052945
109Spinal canal stenosis (HP:0003416)1.89609905
110Neoplasm of the peripheral nervous system (HP:0100007)1.89000281
111Hemiplegia (HP:0002301)1.88310427
112Gait ataxia (HP:0002066)1.87767489
113Amyotrophic lateral sclerosis (HP:0007354)1.86356654
114Hypoventilation (HP:0002791)1.85217252
115Choreoathetosis (HP:0001266)1.85086567
116Abnormality of salivation (HP:0100755)1.84956561
117Generalized hypotonia (HP:0001290)1.84426727
118Atrioventricular block (HP:0001678)1.83376990
119Lower limb asymmetry (HP:0100559)1.82337984
120Resting tremor (HP:0002322)1.80729612
121Lower limb amyotrophy (HP:0007210)1.80634771
122Sensory axonal neuropathy (HP:0003390)1.80042000
123Split foot (HP:0001839)1.78601756
124Increased circulating renin level (HP:0000848)1.78600622
125Thickened helices (HP:0000391)1.78453759
126Abnormality of the periventricular white matter (HP:0002518)1.77287810
127Slow saccadic eye movements (HP:0000514)1.76183114
128Shoulder girdle muscle weakness (HP:0003547)1.75324145
129Prolonged QT interval (HP:0001657)1.73138434
130Abnormality of saccadic eye movements (HP:0000570)1.72704886
131Papilledema (HP:0001085)1.72530929
132Hyperthyroidism (HP:0000836)1.72447632
133Abnormal atrioventricular conduction (HP:0005150)1.72233324
134Sleep apnea (HP:0010535)1.72108022
135Narrow nasal bridge (HP:0000446)1.71460145
136Dementia (HP:0000726)1.68929362
137Abnormal EKG (HP:0003115)1.67208322
138Nonprogressive disorder (HP:0003680)1.66601474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.17110606
2NTRK34.04104167
3EPHA43.95970817
4DAPK23.72108105
5MAP3K93.54281834
6MAP3K42.99112354
7MAP3K122.92306536
8MAP2K72.71133528
9CDK192.67628684
10DAPK12.54556260
11MINK12.52285729
12PLK22.30539335
13CCNB12.27124522
14MARK12.21083073
15MAP2K42.01716537
16PAK61.97982993
17RIPK41.76739958
18AKT31.70501476
19KSR21.67888366
20NTRK11.65200910
21ARAF1.58934642
22CAMKK11.57158437
23GRK51.52840901
24PRPF4B1.51661380
25NTRK21.36788013
26PNCK1.36493061
27CDK51.31615712
28CAMKK21.30716668
29KSR11.30537985
30OXSR11.30020056
31PRKCG1.20969476
32MARK21.19209763
33NEK11.14321977
34MAPK131.11607721
35PTK2B1.04268169
36PDK41.01252532
37PDK31.01252532
38STK381.01072401
39PKN11.00806746
40PRKD31.00438732
41DAPK31.00348200
42SIK30.96900582
43LATS20.87146029
44CDK180.87065879
45STK160.86150410
46CAMK2A0.83696378
47SGK4940.82647672
48SGK2230.82647672
49IRAK20.81703006
50CDK150.81199656
51CDK140.80475339
52SIK20.80162712
53TAOK10.79995652
54RIPK10.79376397
55SGK20.78802716
56MAP3K20.75894615
57RAF10.72813316
58NME10.72666364
59BRAF0.72044358
60TSSK60.71749375
61CAMK10.71485804
62UHMK10.70225559
63CDK11A0.68889793
64TYRO30.66456477
65MUSK0.66127899
66PDK10.65418443
67MAP3K130.64235047
68STK110.63939441
69MAP3K110.62662154
70TNK20.61410773
71PDPK10.61207228
72LIMK10.59252426
73MAPK100.57861728
74CAMK2B0.57385166
75SGK30.57137630
76BMPR20.56535964
77PHKG20.55952623
78PHKG10.55952623
79LMTK20.55781733
80TNIK0.52832994
81FES0.51913649
82PRKCH0.50931105
83SGK10.50164819
84ALK0.49899983
85RET0.49698277
86MAP2K10.48362094
87PRKG20.47951264
88PDK20.47556625
89FER0.47453507
90MAPK120.46497126
91CAMK1D0.46074539
92MAP2K60.45753773
93PRKCE0.44272196
94DYRK1A0.42077710
95MAPK70.41465049
96CSNK1G20.38180438
97NEK60.36890735
98PAK30.36545838
99FGR0.36320185
100CAMK40.35841499
101FYN0.35168606
102ADRBK10.34787245
103BRSK10.34722851
104MAP3K10.34055143
105ERBB20.33609078
106PRKCA0.33593096
107RPS6KA30.33583261
108PINK10.33486417
109CAMK2G0.32125926
110MAPK80.28782427
111ROCK10.28353597
112BCR0.27960654
113CDC42BPA0.27454041
114PRKCZ0.27323915
115PAK10.25017354
116PLK30.24396208
117PRKG10.23732357
118ROCK20.23484253
119CAMK2D0.23451831
120CAMK1G0.21786075
121MOS0.20715089
122RPS6KB10.20466098
123TESK10.20409011
124PRKACA0.20308604
125ABL20.20160058
126DDR20.19997844

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.43964557
2Nicotine addiction_Homo sapiens_hsa050333.88996743
3Collecting duct acid secretion_Homo sapiens_hsa049662.95118751
4Olfactory transduction_Homo sapiens_hsa047402.75885990
5Long-term potentiation_Homo sapiens_hsa047202.71705753
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69887932
7Circadian entrainment_Homo sapiens_hsa047132.60971418
8Amphetamine addiction_Homo sapiens_hsa050312.53641857
9GABAergic synapse_Homo sapiens_hsa047272.39990289
10Glutamatergic synapse_Homo sapiens_hsa047242.38177700
11Morphine addiction_Homo sapiens_hsa050322.31755281
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16540296
13Salivary secretion_Homo sapiens_hsa049702.16093372
14Insulin secretion_Homo sapiens_hsa049112.04990138
15Dopaminergic synapse_Homo sapiens_hsa047282.00173775
16Gastric acid secretion_Homo sapiens_hsa049711.88180220
17Taste transduction_Homo sapiens_hsa047421.78921576
18Renin secretion_Homo sapiens_hsa049241.69784011
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67581252
20Oxytocin signaling pathway_Homo sapiens_hsa049211.66439731
21Cholinergic synapse_Homo sapiens_hsa047251.64646928
22Vibrio cholerae infection_Homo sapiens_hsa051101.64549123
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56754452
24Calcium signaling pathway_Homo sapiens_hsa040201.54761511
25Serotonergic synapse_Homo sapiens_hsa047261.49304491
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48329595
27Long-term depression_Homo sapiens_hsa047301.45702997
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39744067
29GnRH signaling pathway_Homo sapiens_hsa049121.34089436
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33364914
31Gap junction_Homo sapiens_hsa045401.22762539
32Cocaine addiction_Homo sapiens_hsa050301.18302494
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15686041
34Cardiac muscle contraction_Homo sapiens_hsa042601.12544368
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12216745
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10762154
37cAMP signaling pathway_Homo sapiens_hsa040241.10493784
38Oxidative phosphorylation_Homo sapiens_hsa001901.07641201
39Glioma_Homo sapiens_hsa052141.07550778
40ErbB signaling pathway_Homo sapiens_hsa040121.06845731
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05353468
42Alcoholism_Homo sapiens_hsa050341.05200371
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03503944
44Oocyte meiosis_Homo sapiens_hsa041141.02333763
45Type II diabetes mellitus_Homo sapiens_hsa049301.01916182
46Estrogen signaling pathway_Homo sapiens_hsa049151.01077579
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97179820
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93925355
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88605055
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88383995
51Axon guidance_Homo sapiens_hsa043600.88011211
52Melanogenesis_Homo sapiens_hsa049160.86975278
53Alzheimers disease_Homo sapiens_hsa050100.81654690
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.79313314
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77823837
56Rheumatoid arthritis_Homo sapiens_hsa053230.72860660
57Phototransduction_Homo sapiens_hsa047440.72669593
58Dorso-ventral axis formation_Homo sapiens_hsa043200.68709821
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67148394
60MAPK signaling pathway_Homo sapiens_hsa040100.66119618
61Glucagon signaling pathway_Homo sapiens_hsa049220.63886947
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.63763723
63Circadian rhythm_Homo sapiens_hsa047100.61983867
64Pancreatic secretion_Homo sapiens_hsa049720.61099397
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57345144
66Parkinsons disease_Homo sapiens_hsa050120.56869517
67VEGF signaling pathway_Homo sapiens_hsa043700.53997945
68Phagosome_Homo sapiens_hsa041450.53678401
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53582250
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53203886
71Arginine and proline metabolism_Homo sapiens_hsa003300.52444646
72Dilated cardiomyopathy_Homo sapiens_hsa054140.51255159
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.50672044
74Inositol phosphate metabolism_Homo sapiens_hsa005620.50327188
75mTOR signaling pathway_Homo sapiens_hsa041500.49625018
76Insulin signaling pathway_Homo sapiens_hsa049100.48863820
77Choline metabolism in cancer_Homo sapiens_hsa052310.48035277
78Thyroid hormone synthesis_Homo sapiens_hsa049180.47584917
79Ras signaling pathway_Homo sapiens_hsa040140.47350442
80Vitamin B6 metabolism_Homo sapiens_hsa007500.46001895
81Histidine metabolism_Homo sapiens_hsa003400.45251299
82Regulation of autophagy_Homo sapiens_hsa041400.45185045
83Nitrogen metabolism_Homo sapiens_hsa009100.44046490
84Ovarian steroidogenesis_Homo sapiens_hsa049130.43127244
85Huntingtons disease_Homo sapiens_hsa050160.43062700
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40894101
87Prion diseases_Homo sapiens_hsa050200.40016960
88beta-Alanine metabolism_Homo sapiens_hsa004100.39716728
89Rap1 signaling pathway_Homo sapiens_hsa040150.39120523
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38378117
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38236248
92Endocytosis_Homo sapiens_hsa041440.37374126
93Wnt signaling pathway_Homo sapiens_hsa043100.36637137
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35921086
95Arginine biosynthesis_Homo sapiens_hsa002200.32922314
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32861113
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32664593
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.32660089
99Bile secretion_Homo sapiens_hsa049760.31385299
100Hippo signaling pathway_Homo sapiens_hsa043900.31343835
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28874404
102Renal cell carcinoma_Homo sapiens_hsa052110.27248978
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27184795
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26114776
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25564733
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24872834
107AMPK signaling pathway_Homo sapiens_hsa041520.24780295
108African trypanosomiasis_Homo sapiens_hsa051430.24448268
109Fructose and mannose metabolism_Homo sapiens_hsa000510.24202837
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.23723815
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23682521
112Mineral absorption_Homo sapiens_hsa049780.23261865
113Protein digestion and absorption_Homo sapiens_hsa049740.22782759
114ABC transporters_Homo sapiens_hsa020100.20787371
115Fatty acid biosynthesis_Homo sapiens_hsa000610.19428530
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15809937

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