KCNK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.39915539
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.39915539
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.39915539
4modulation by symbiont of host immune response (GO:0052553)6.39915539
5positive regulation by symbiont of host defense response (GO:0052509)6.39915539
6modulation by symbiont of host defense response (GO:0052031)6.39915539
7microglial cell activation (GO:0001774)5.72494264
8regulation of interferon-beta biosynthetic process (GO:0045357)5.40358530
9macrophage activation involved in immune response (GO:0002281)4.99650800
10positive regulation of antigen processing and presentation (GO:0002579)4.55569313
11response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.36323611
12response to host immune response (GO:0052572)4.36323611
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29143475
14positive regulation of chemokine secretion (GO:0090197)4.28602521
15L-fucose catabolic process (GO:0042355)4.18977061
16fucose catabolic process (GO:0019317)4.18977061
17L-fucose metabolic process (GO:0042354)4.18977061
18behavioral response to nicotine (GO:0035095)4.15505247
19positive regulation of interferon-alpha production (GO:0032727)4.14585383
20regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.13235829
21tryptophan catabolic process (GO:0006569)4.02441417
22indole-containing compound catabolic process (GO:0042436)4.02441417
23indolalkylamine catabolic process (GO:0046218)4.02441417
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.01917095
25response to host (GO:0075136)4.01917095
26response to host defenses (GO:0052200)4.01917095
27response to peptidoglycan (GO:0032494)3.98481368
28G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.91954871
29regulation of antigen processing and presentation (GO:0002577)3.91468550
30regulation of interferon-alpha production (GO:0032647)3.91237626
31macrophage activation (GO:0042116)3.91173585
32superoxide anion generation (GO:0042554)3.87142729
33kynurenine metabolic process (GO:0070189)3.81652935
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.79042460
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.79042460
36regulation of translation, ncRNA-mediated (GO:0045974)3.79042460
37indolalkylamine metabolic process (GO:0006586)3.78525042
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.75920494
39regulation of establishment of cell polarity (GO:2000114)3.75471380
40NAD biosynthetic process (GO:0009435)3.72936180
41negative regulation of granulocyte differentiation (GO:0030853)3.70890235
42neutrophil activation involved in immune response (GO:0002283)3.70830430
43immunoglobulin mediated immune response (GO:0016064)3.68735448
44endosome to melanosome transport (GO:0035646)3.68116133
45endosome to pigment granule transport (GO:0043485)3.68116133
46regulation of chemokine secretion (GO:0090196)3.67853613
47establishment of protein localization to Golgi (GO:0072600)3.60330402
48positive regulation of interferon-beta production (GO:0032728)3.60283332
49regulation of hippo signaling (GO:0035330)3.58316130
50NIK/NF-kappaB signaling (GO:0038061)3.55736590
51phosphatidylinositol acyl-chain remodeling (GO:0036149)3.51853179
52regulation of RIG-I signaling pathway (GO:0039535)3.49500662
53regulation of establishment or maintenance of cell polarity (GO:0032878)3.48625018
54I-kappaB phosphorylation (GO:0007252)3.48184077
55neutrophil activation (GO:0042119)3.46661983
56glycosphingolipid catabolic process (GO:0046479)3.41580026
57regulation of B cell receptor signaling pathway (GO:0050855)3.40950167
58germinal center formation (GO:0002467)3.38724361
59cellular ketone body metabolic process (GO:0046950)3.38169072
60tryptophan metabolic process (GO:0006568)3.37957965
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.34874002
62response to muramyl dipeptide (GO:0032495)3.33717781
63granulocyte activation (GO:0036230)3.32040030
64ceramide catabolic process (GO:0046514)3.24971188
65protein K48-linked deubiquitination (GO:0071108)3.22864903
66positive regulation of gamma-delta T cell activation (GO:0046645)3.21802709
67cellular extravasation (GO:0045123)3.17711055
68oxidative demethylation (GO:0070989)3.13606178
69respiratory burst (GO:0045730)3.13224013
70positive regulation of cellular amide metabolic process (GO:0034250)3.12994425
71positive regulation of CREB transcription factor activity (GO:0032793)3.09900914
72myeloid cell activation involved in immune response (GO:0002275)3.08641371
73negative regulation of interleukin-12 production (GO:0032695)3.08094648
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06322218
75DNA deamination (GO:0045006)3.06248984
76glycolipid catabolic process (GO:0019377)3.05409111
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04453724
78multicellular organism reproduction (GO:0032504)3.03697056
79sulfation (GO:0051923)3.02406492
80response to pheromone (GO:0019236)3.01213666
81positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.00630671
82negative regulation of sodium ion transport (GO:0010766)2.99286513
83hyaluronan catabolic process (GO:0030214)2.97574775
84signal peptide processing (GO:0006465)2.96742708
85regulation of mast cell degranulation (GO:0043304)2.96085631
86ketone body metabolic process (GO:1902224)2.95510345
87detection of light stimulus involved in sensory perception (GO:0050962)2.94599477
88detection of light stimulus involved in visual perception (GO:0050908)2.94599477
89positive regulation of fatty acid beta-oxidation (GO:0032000)2.90337814
90oligosaccharide catabolic process (GO:0009313)2.89421707
91regulation of pigment cell differentiation (GO:0050932)2.87808677
92positive regulation of fatty acid oxidation (GO:0046321)2.87752077
93prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.87459607
94regulation of interferon-beta production (GO:0032648)2.86957421
95positive regulation of defense response to virus by host (GO:0002230)2.86920244
96pinocytosis (GO:0006907)2.86044406
97purinergic nucleotide receptor signaling pathway (GO:0035590)2.84917322
98positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83761490
99antigen processing and presentation of endogenous antigen (GO:0019883)2.83054494
100negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.82946191
101phosphatidylserine acyl-chain remodeling (GO:0036150)2.81815749
102regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.81734983
103pyridine nucleotide biosynthetic process (GO:0019363)2.81193667
104nicotinamide nucleotide biosynthetic process (GO:0019359)2.81193667
105myeloid dendritic cell activation (GO:0001773)2.81111257
106detection of molecule of bacterial origin (GO:0032490)2.81031527
107regulation of female gonad development (GO:2000194)2.80476085
108regulation of sarcomere organization (GO:0060297)2.80328174
109monoubiquitinated protein deubiquitination (GO:0035520)2.78908727
110cellular biogenic amine catabolic process (GO:0042402)2.78045158
111amine catabolic process (GO:0009310)2.78045158
112regulation of mast cell activation involved in immune response (GO:0033006)2.77889072
113protein K63-linked deubiquitination (GO:0070536)2.77238709
114dendritic cell chemotaxis (GO:0002407)2.76696893
115positive regulation of B cell differentiation (GO:0045579)2.76156990
116myeloid dendritic cell differentiation (GO:0043011)2.75651181
117reflex (GO:0060004)2.75470101
118positive regulation of developmental pigmentation (GO:0048087)2.75338367
119myeloid leukocyte activation (GO:0002274)2.75244110
120indole-containing compound metabolic process (GO:0042430)2.74108904
121snRNA transcription (GO:0009301)2.74062719
122negative regulation of protein localization to cell surface (GO:2000009)2.71705199
123dendritic cell migration (GO:0036336)2.70670306
124negative regulation of interleukin-6 production (GO:0032715)2.70596255
125protein targeting to vacuole (GO:0006623)2.70472900
126protein targeting to lysosome (GO:0006622)2.70472900
127establishment of protein localization to vacuole (GO:0072666)2.70472900
128DNA demethylation (GO:0080111)2.68492437
129positive regulation of interleukin-12 production (GO:0032735)2.68452638
130interferon-gamma secretion (GO:0072643)2.68364422
131negative regulation of mast cell activation (GO:0033004)2.68321871
132basic amino acid transport (GO:0015802)2.67635424
133cellular response to exogenous dsRNA (GO:0071360)2.67333983
134positive regulation of chemokine production (GO:0032722)2.66852114
135regulation of germinal center formation (GO:0002634)2.66601279
136striated muscle atrophy (GO:0014891)2.65674568
137protein targeting to Golgi (GO:0000042)2.65659339
138autophagic vacuole fusion (GO:0000046)2.64514221
139interferon-gamma-mediated signaling pathway (GO:0060333)2.63825749
140dendritic cell differentiation (GO:0097028)2.63278389
141regulation of mast cell activation (GO:0033003)2.63121457
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60644616
143phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.60599160
144lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60098242
145sphingolipid catabolic process (GO:0030149)2.58579465
146B cell mediated immunity (GO:0019724)2.57189311
147neutrophil mediated immunity (GO:0002446)2.56384918
148retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55202633
149hydrogen peroxide biosynthetic process (GO:0050665)2.55104318
150regulation of interleukin-12 production (GO:0032655)2.53636428
151positive regulation of fatty acid transport (GO:2000193)2.53085426
152G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.51482034
153natural killer cell mediated immunity (GO:0002228)2.51090073
154natural killer cell mediated cytotoxicity (GO:0042267)2.51090073
155G-protein coupled receptor internalization (GO:0002031)2.49568542
156B cell homeostasis (GO:0001782)2.49513621
157cellular response to ATP (GO:0071318)2.48246667
158cytokine secretion (GO:0050663)2.47426341
159mature B cell differentiation (GO:0002335)2.45826654
160adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.45324255
161negative regulation of telomere maintenance (GO:0032205)2.44975372
162positive regulation of mast cell activation (GO:0033005)2.43419622
163regulation of interleukin-8 biosynthetic process (GO:0045414)2.42058094
164production of molecular mediator involved in inflammatory response (GO:0002532)2.42029109
165positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.41326037
166regulation of memory T cell differentiation (GO:0043380)2.41256899
167monocyte chemotaxis (GO:0002548)2.40666776
168axoneme assembly (GO:0035082)2.39936753
169leukocyte mediated cytotoxicity (GO:0001909)2.38683670
170thyroid hormone metabolic process (GO:0042403)2.37836657
171positive regulation of mast cell degranulation (GO:0043306)2.37783852
172positive regulation of mast cell activation involved in immune response (GO:0033008)2.37783852
173regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.37778469
174piRNA metabolic process (GO:0034587)2.37305225
175protein localization to Golgi apparatus (GO:0034067)2.35162697
176negative regulation of reactive oxygen species metabolic process (GO:2000378)2.33447828
177cilium or flagellum-dependent cell motility (GO:0001539)2.32027227
178positive regulation of digestive system process (GO:0060456)2.31185932
179positive regulation of icosanoid secretion (GO:0032305)2.30260068
180prostate gland growth (GO:0060736)2.29936215
181photoreceptor cell maintenance (GO:0045494)2.29927573
182regulation of gene silencing by RNA (GO:0060966)2.29477499
183regulation of posttranscriptional gene silencing (GO:0060147)2.29477499
184regulation of gene silencing by miRNA (GO:0060964)2.29477499
185positive regulation of triglyceride biosynthetic process (GO:0010867)2.29221523
186primary amino compound metabolic process (GO:1901160)2.29135402
187interkinetic nuclear migration (GO:0022027)2.29073246
188negative regulation of interleukin-1 production (GO:0032692)2.28417557
189G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.28043091
190intestinal epithelial cell development (GO:0060576)2.27779816
191regulation of interleukin-8 secretion (GO:2000482)2.27146151
192phosphatidylcholine acyl-chain remodeling (GO:0036151)2.25815493
193positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.24823963
194cytokine biosynthetic process (GO:0042089)2.24616935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.12695864
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.01965509
3IRF8_27001747_Chip-Seq_BMDM_Mouse4.45769361
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.98743378
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.97710815
6* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.34640431
7ZNF274_21170338_ChIP-Seq_K562_Hela3.23059876
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21309321
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.20651371
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.13845060
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05215514
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03254897
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83939807
14VDR_22108803_ChIP-Seq_LS180_Human2.79718619
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77945608
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75933053
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70804639
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53847422
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50068191
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.39488842
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32565298
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32395746
23ER_23166858_ChIP-Seq_MCF-7_Human2.22573289
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20154924
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.19308691
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17792243
27SPI1_23547873_ChIP-Seq_NB4_Human2.17033516
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15029057
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.11412630
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.06343105
31GBX2_23144817_ChIP-Seq_PC3_Human1.92734654
32DROSHA_22980978_ChIP-Seq_HELA_Human1.92374304
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92306170
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84042350
35EZH2_22144423_ChIP-Seq_EOC_Human1.83583127
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81487038
37VDR_24787735_ChIP-Seq_THP-1_Human1.78136415
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.77545229
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74694332
40PU_27001747_Chip-Seq_BMDM_Mouse1.72553468
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71306020
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.70204572
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69475184
44SCL_19346495_ChIP-Seq_HPC-7_Human1.65291004
45AHR_22903824_ChIP-Seq_MCF-7_Human1.64799048
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64187653
47* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61199485
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60975724
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59958085
50BCAT_22108803_ChIP-Seq_LS180_Human1.56814774
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53060446
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.52891107
53SPI1_23127762_ChIP-Seq_K562_Human1.52345561
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51197417
55RUNX_20019798_ChIP-Seq_JUKART_Human1.50706420
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50310334
57MYB_26560356_Chip-Seq_TH2_Human1.50014185
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.44415822
59E2F7_22180533_ChIP-Seq_HELA_Human1.41560370
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41375305
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41229180
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41012709
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41012555
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41012555
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.39005305
66* MYB_26560356_Chip-Seq_TH1_Human1.38916939
67* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36398194
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36386023
69STAT3_23295773_ChIP-Seq_U87_Human1.36056886
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.34342754
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33424058
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.33062692
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.32501332
74TCF4_23295773_ChIP-Seq_U87_Human1.29058435
75TP53_16413492_ChIP-PET_HCT116_Human1.28387006
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27202354
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26855967
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26740250
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26082875
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26059708
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25616345
82TAF15_26573619_Chip-Seq_HEK293_Human1.24324295
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24066115
84* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21985044
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21646153
86* ERA_21632823_ChIP-Seq_H3396_Human1.21244132
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21008580
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.20833966
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20734532
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.20734532
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20545904
92HOXB7_26014856_ChIP-Seq_BT474_Human1.20432366
93VDR_24763502_ChIP-Seq_THP-1_Human1.20420536
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19780597
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.19411057
96AR_25329375_ChIP-Seq_VCAP_Human1.16123956
97P300_19829295_ChIP-Seq_ESCs_Human1.15472714
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.14652813
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14056111
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13855796
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13765255
102AR_21572438_ChIP-Seq_LNCaP_Human1.13749568
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.11920560
104GATA3_26560356_Chip-Seq_TH2_Human1.11643403
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09667241
106TCF4_22108803_ChIP-Seq_LS180_Human1.08927893
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08281568
108* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08006678
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.07669810
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06633502
111P53_21459846_ChIP-Seq_SAOS-2_Human1.05654416
112NANOG_20526341_ChIP-Seq_ESCs_Human1.03771578
113OCT4_20526341_ChIP-Seq_ESCs_Human1.03415713
114* MAF_26560356_Chip-Seq_TH1_Human1.03174870
115AR_20517297_ChIP-Seq_VCAP_Human1.02795214
116SMAD4_21799915_ChIP-Seq_A2780_Human1.01623866
117ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01557768
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01450567
119CEBPB_22108803_ChIP-Seq_LS180_Human1.01109936
120EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00897193
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00259285
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99699027
123GATA3_27048872_Chip-Seq_THYMUS_Human0.99669500
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99649233
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99296428
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99026208
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98831948
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98331437
129CBP_20019798_ChIP-Seq_JUKART_Human0.98030259
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98030259
131RXR_22108803_ChIP-Seq_LS180_Human0.98008127
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97879527
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97836622
134NANOG_19829295_ChIP-Seq_ESCs_Human0.96880927
135SOX2_19829295_ChIP-Seq_ESCs_Human0.96880927
136RAC3_21632823_ChIP-Seq_H3396_Human0.96738189
137* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96038040
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.95983889
139STAT1_20625510_ChIP-Seq_HELA_Human0.95684415
140FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95221425
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95141489
142EWS_26573619_Chip-Seq_HEK293_Human0.94268469
143OCT1_27270436_Chip-Seq_PROSTATE_Human0.93504250
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93208748
145GATA4_25053715_ChIP-Seq_YYC3_Human0.93175964
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93159457
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92576765
148GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92430445
149FLI1_21867929_ChIP-Seq_TH2_Mouse0.92242908
150RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92196467
151RUNX2_22187159_ChIP-Seq_PCA_Human0.91255402
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.91213629
153VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90742588
154CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90546868
155FOXM1_23109430_ChIP-Seq_U2OS_Human0.89951194
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.89121654
157SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88757128
158SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88757128
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88303791
160STAT3_18555785_Chip-Seq_ESCs_Mouse0.88141569
161RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87951423
162FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86176091
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85916276
164KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85622942
165KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85622942
166KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85622942
167CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85250545
168PU1_27457419_Chip-Seq_LIVER_Mouse0.84037585
169GATA1_22025678_ChIP-Seq_K562_Human0.83211556
170GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80788899
171SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80642215
172TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80598419
173SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79746108
174SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79042649
175NMYC_18555785_Chip-Seq_ESCs_Mouse0.78688971
176ZFX_18555785_Chip-Seq_ESCs_Mouse0.78394327
177JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77841647
178OCT4_18555785_Chip-Seq_ESCs_Mouse0.77755850
179* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74986274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.72198687
2MP0006082_CNS_inflammation3.21947520
3MP0002254_reproductive_system_inflammat3.19664215
4MP0003195_calcinosis3.08437950
5MP0005058_abnormal_lysosome_morphology2.90436747
6MP0003303_peritoneal_inflammation2.75570470
7MP0002419_abnormal_innate_immunity2.67825882
8MP0004043_abnormal_pH_regulation2.67183879
9MP0005671_abnormal_response_to2.59395477
10MP0000427_abnormal_hair_cycle2.56748075
11MP0002148_abnormal_hypersensitivity_rea2.52087496
12MP0005377_hearing/vestibular/ear_phenot2.49090261
13MP0003878_abnormal_ear_physiology2.49090261
14MP0009780_abnormal_chondrocyte_physiolo2.45139133
15MP0009046_muscle_twitch2.45018132
16MP0003646_muscle_fatigue2.44645495
17MP0005387_immune_system_phenotype2.41802570
18MP0001790_abnormal_immune_system2.41802570
19MP0008872_abnormal_physiological_respon2.39888558
20MP0002452_abnormal_antigen_presenting2.35013979
21MP0003436_decreased_susceptibility_to2.34751930
22MP0005310_abnormal_salivary_gland2.24920659
23MP0001873_stomach_inflammation2.24679241
24MP0005000_abnormal_immune_tolerance2.22540967
25MP0001800_abnormal_humoral_immune2.19064907
26MP0000685_abnormal_immune_system2.13248469
27MP0005410_abnormal_fertilization2.13083785
28MP0004381_abnormal_hair_follicle2.10259719
29MP0002723_abnormal_immune_serum2.08070050
30MP0001968_abnormal_touch/_nociception2.07066459
31MP0002396_abnormal_hematopoietic_system2.02495041
32MP0005025_abnormal_response_to2.02108188
33MP0001881_abnormal_mammary_gland2.02064389
34MP0004510_myositis1.98525706
35MP0003191_abnormal_cellular_cholesterol1.98239182
36MP0009785_altered_susceptibility_to1.97654572
37MP0001819_abnormal_immune_cell1.96600654
38MP0002736_abnormal_nociception_after1.94627288
39MP0008961_abnormal_basal_metabolism1.94476829
40MP0005464_abnormal_platelet_physiology1.94262140
41MP0002420_abnormal_adaptive_immunity1.92121331
42MP0002138_abnormal_hepatobiliary_system1.83777419
43MP0003724_increased_susceptibility_to1.82705208
44MP0002277_abnormal_respiratory_mucosa1.82091628
45MP0001501_abnormal_sleep_pattern1.81789413
46MP0005083_abnormal_biliary_tract1.81738581
47MP0005551_abnormal_eye_electrophysiolog1.81437247
48MP0000470_abnormal_stomach_morphology1.76120888
49MP0003787_abnormal_imprinting1.75999133
50MP0005646_abnormal_pituitary_gland1.74488666
51MP0009333_abnormal_splenocyte_physiolog1.72605944
52MP0005451_abnormal_body_composition1.72330862
53MP0001485_abnormal_pinna_reflex1.63735153
54MP0003172_abnormal_lysosome_physiology1.62915547
55MP0008260_abnormal_autophagy1.62754960
56MP0001533_abnormal_skeleton_physiology1.56447994
57MP0001853_heart_inflammation1.52668090
58MP0001845_abnormal_inflammatory_respons1.52515346
59MP0009840_abnormal_foam_cell1.51771825
60MP0000579_abnormal_nail_morphology1.51144896
61MP0008877_abnormal_DNA_methylation1.50963450
62MP0002405_respiratory_system_inflammati1.49985657
63MP0010155_abnormal_intestine_physiology1.47896328
64MP0004947_skin_inflammation1.46321558
65MP0001919_abnormal_reproductive_system1.45400486
66MP0003828_pulmonary_edema1.44073961
67MP0003718_maternal_effect1.43545491
68MP0000716_abnormal_immune_system1.43198826
69MP0003300_gastrointestinal_ulcer1.41588557
70MP0003011_delayed_dark_adaptation1.40550484
71MP0005075_abnormal_melanosome_morpholog1.38716751
72MP0003448_altered_tumor_morphology1.38309750
73MP0000490_abnormal_crypts_of1.37806340
74MP0003693_abnormal_embryo_hatching1.35103751
75MP0002876_abnormal_thyroid_physiology1.34543612
76MP0002166_altered_tumor_susceptibility1.33673661
77MP0002398_abnormal_bone_marrow1.32855857
78MP0001851_eye_inflammation1.32045372
79MP0000015_abnormal_ear_pigmentation1.31293715
80MP0005647_abnormal_sex_gland1.30169418
81MP0000569_abnormal_digit_pigmentation1.28176583
82MP0001765_abnormal_ion_homeostasis1.26729973
83MP0010329_abnormal_lipoprotein_level1.26465809
84MP0004142_abnormal_muscle_tone1.25773965
85MP0008469_abnormal_protein_level1.25016191
86MP0000230_abnormal_systemic_arterial1.23458145
87MP0003136_yellow_coat_color1.22407337
88MP0000383_abnormal_hair_follicle1.22189966
89MP0002006_tumorigenesis1.21957969
90MP0001986_abnormal_taste_sensitivity1.21923462
91MP0000689_abnormal_spleen_morphology1.21886075
92MP0003638_abnormal_response/metabolism_1.21607665
93MP0002998_abnormal_bone_remodeling1.19482267
94MP0000465_gastrointestinal_hemorrhage1.18776734
95MP0002722_abnormal_immune_system1.18574132
96MP0005257_abnormal_intraocular_pressure1.17673509
97MP0008058_abnormal_DNA_repair1.17489779
98MP0005085_abnormal_gallbladder_physiolo1.16379634
99MP0004147_increased_porphyrin_level1.15999937
100MP0000627_abnormal_mammary_gland1.15028001
101MP0000538_abnormal_urinary_bladder1.14174552
102MP0002429_abnormal_blood_cell1.13989968
103MP0008004_abnormal_stomach_pH1.13881445
104MP0001545_abnormal_hematopoietic_system1.13230321
105MP0005397_hematopoietic_system_phenotyp1.13230321
106MP0002009_preneoplasia1.13061356
107MP0003183_abnormal_peptide_metabolism1.11775156
108MP0004782_abnormal_surfactant_physiolog1.11260198
109MP0009278_abnormal_bone_marrow1.06888317
110MP0003866_abnormal_defecation1.06862117
111MP0009745_abnormal_behavioral_response1.04071396
112MP0008875_abnormal_xenobiotic_pharmacok1.02832942
113MP0001664_abnormal_digestion1.01762333
114MP0010307_abnormal_tumor_latency1.01375770
115MP0004130_abnormal_muscle_cell1.01165881
116MP0001542_abnormal_bone_strength1.00708389
117MP0005389_reproductive_system_phenotype0.99613366
118MP0008995_early_reproductive_senescence0.98280856
119MP0005448_abnormal_energy_balance0.97036929
120MP0003763_abnormal_thymus_physiology0.96783214
121MP0010386_abnormal_urinary_bladder0.96597852
122MP0004885_abnormal_endolymph0.94630570
123MP0008007_abnormal_cellular_replicative0.93594790
124MP0003566_abnormal_cell_adhesion0.93463401
125MP0002095_abnormal_skin_pigmentation0.92104130
126MP0008057_abnormal_DNA_replication0.90863048
127MP0002168_other_aberrant_phenotype0.90495212
128MP0000343_altered_response_to0.89799645
129MP0001346_abnormal_lacrimal_gland0.89234650
130MP0003453_abnormal_keratinocyte_physiol0.89184531
131MP0002928_abnormal_bile_duct0.87978787
132MP0002735_abnormal_chemical_nociception0.87547529
133MP0004742_abnormal_vestibular_system0.87356560
134MP0005390_skeleton_phenotype0.85969054
135MP0000371_diluted_coat_color0.85774380
136MP0000858_altered_metastatic_potential0.84943086
137MP0001970_abnormal_pain_threshold0.84898216
138MP0005174_abnormal_tail_pigmentation0.84743133
139MP0002933_joint_inflammation0.83699645
140MP0001216_abnormal_epidermal_layer0.83665985
141MP0004808_abnormal_hematopoietic_stem0.83184258
142MP0009764_decreased_sensitivity_to0.81805620
143MP0004019_abnormal_vitamin_homeostasis0.80933988
144MP0002067_abnormal_sensory_capabilities0.80813311
145MP0002098_abnormal_vibrissa_morphology0.80735386
146MP0002733_abnormal_thermal_nociception0.80654273
147MP0004264_abnormal_extraembryonic_tissu0.80296584
148MP0000767_abnormal_smooth_muscle0.79711636
149MP0009115_abnormal_fat_cell0.79289618
150MP0005167_abnormal_blood-brain_barrier0.78766630
151MP0003075_altered_response_to0.77866043
152MP0004883_abnormal_blood_vessel0.76762554
153MP0000467_abnormal_esophagus_morphology0.75652512
154MP0003252_abnormal_bile_duct0.75479171
155MP0003690_abnormal_glial_cell0.75412819
156MP0003111_abnormal_nucleus_morphology0.74991144
157MP0003045_fibrosis0.74745851
158MP0001663_abnormal_digestive_system0.73826678
159MP0005253_abnormal_eye_physiology0.73751338
160MP0002693_abnormal_pancreas_physiology0.73151340
161MP0002163_abnormal_gland_morphology0.72916149
162MP0010678_abnormal_skin_adnexa0.72111280
163MP0005670_abnormal_white_adipose0.70699321
164MP0005395_other_phenotype0.70660497

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.52632851
2Systemic lupus erythematosus (HP:0002725)5.45530346
3Eczematoid dermatitis (HP:0000976)5.44220763
4Recurrent bacterial skin infections (HP:0005406)5.21919272
5Genetic anticipation (HP:0003743)5.04001420
6Abnormality of glycolipid metabolism (HP:0010969)4.61289949
7Abnormality of liposaccharide metabolism (HP:0010968)4.61289949
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.61289949
9Pancreatic cysts (HP:0001737)4.56742950
10Glomerulonephritis (HP:0000099)4.24551547
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.23172830
12Vacuolated lymphocytes (HP:0001922)4.06370540
13Protruding tongue (HP:0010808)4.05696666
14Abnormality of macrophages (HP:0004311)3.84699933
15Pancreatic fibrosis (HP:0100732)3.80576993
16Congenital stationary night blindness (HP:0007642)3.74762884
17Progressive cerebellar ataxia (HP:0002073)3.64592954
18Hyperventilation (HP:0002883)3.60916667
19Molar tooth sign on MRI (HP:0002419)3.57860167
20Abnormality of midbrain morphology (HP:0002418)3.57860167
21Prostate neoplasm (HP:0100787)3.56029415
22Recurrent fungal infections (HP:0002841)3.52811559
23Increased cerebral lipofuscin (HP:0011813)3.47760679
24True hermaphroditism (HP:0010459)3.47029700
25Recurrent gram-negative bacterial infections (HP:0005420)3.44577668
26Recurrent skin infections (HP:0001581)3.44401401
27Clumsiness (HP:0002312)3.41643128
28Attenuation of retinal blood vessels (HP:0007843)3.33524081
29Recurrent cutaneous fungal infections (HP:0011370)3.28407809
30Chronic mucocutaneous candidiasis (HP:0002728)3.28407809
31Obstructive lung disease (HP:0006536)3.26138369
32Chronic obstructive pulmonary disease (HP:0006510)3.26138369
33Pustule (HP:0200039)3.25494000
34Mediastinal lymphadenopathy (HP:0100721)3.24552236
35Abnormality of the renal cortex (HP:0011035)3.21758327
36Gingivitis (HP:0000230)3.21571470
37Cystic liver disease (HP:0006706)3.21548594
38Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16799390
39Increased neuronal autofluorescent lipopigment (HP:0002074)3.15432561
40Gaze-evoked nystagmus (HP:0000640)3.12335456
41Myositis (HP:0100614)3.10652302
42Nephronophthisis (HP:0000090)3.04065910
43Abolished electroretinogram (ERG) (HP:0000550)3.03028828
44Decreased circulating renin level (HP:0003351)3.00441021
45Chromsome breakage (HP:0040012)2.99413239
46Abnormality of the renal medulla (HP:0100957)2.96695766
47Retrobulbar optic neuritis (HP:0100654)2.95725224
48Optic neuritis (HP:0100653)2.95725224
49Decreased central vision (HP:0007663)2.93509410
50Orchitis (HP:0100796)2.86957696
51Hematochezia (HP:0002573)2.85288606
52Tubular atrophy (HP:0000092)2.77608391
53Thick nail (HP:0001805)2.76027711
54Dysostosis multiplex (HP:0000943)2.67865393
55Chronic diarrhea (HP:0002028)2.66051337
56Furrowed tongue (HP:0000221)2.65178197
57Amelogenesis imperfecta (HP:0000705)2.64640457
58Nephritis (HP:0000123)2.61879037
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.60102289
60Osteolytic defects of the hand bones (HP:0009699)2.60102289
61Inability to walk (HP:0002540)2.59593418
62Recurrent viral infections (HP:0004429)2.58889187
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57984393
64Hypoplastic ischia (HP:0003175)2.57674586
65Type II lissencephaly (HP:0007260)2.57597358
66Recurrent pneumonia (HP:0006532)2.56595197
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.56557134
68Increased corneal curvature (HP:0100692)2.52824726
69Keratoconus (HP:0000563)2.52824726
70Concave nail (HP:0001598)2.51459917
71Absent/shortened dynein arms (HP:0200106)2.49526575
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.49526575
73Axonal loss (HP:0003447)2.49113389
74Cheilitis (HP:0100825)2.47667972
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44490705
76Abnormality of alanine metabolism (HP:0010916)2.44490705
77Hyperalaninemia (HP:0003348)2.44490705
78Abnormality of binocular vision (HP:0011514)2.42906716
79Diplopia (HP:0000651)2.42906716
80Colitis (HP:0002583)2.40786184
81Macular degeneration (HP:0000608)2.40271921
82Fair hair (HP:0002286)2.38166022
83Abnormal drinking behavior (HP:0030082)2.38142997
84Polydipsia (HP:0001959)2.38142997
85Basal ganglia calcification (HP:0002135)2.35784467
86Increased IgE level (HP:0003212)2.35352330
87Patellar aplasia (HP:0006443)2.32985034
88Meningitis (HP:0001287)2.31105923
89Myocardial infarction (HP:0001658)2.30632174
90Chronic hepatic failure (HP:0100626)2.29211222
91Progressive inability to walk (HP:0002505)2.28529795
92Abnormal rod and cone electroretinograms (HP:0008323)2.28162159
93Autoimmune thrombocytopenia (HP:0001973)2.28077127
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.27488092
95Disinhibition (HP:0000734)2.27440082
96Pendular nystagmus (HP:0012043)2.24748742
97Generalized hypopigmentation of hair (HP:0011358)2.24651097
98Stomach cancer (HP:0012126)2.24249443
99Eosinophilia (HP:0001880)2.23887931
100Periodontitis (HP:0000704)2.23810091
101Aplasia/Hypoplasia of the patella (HP:0006498)2.23280486
102Inflammation of the large intestine (HP:0002037)2.21642994
103Widely spaced teeth (HP:0000687)2.20797214
104Hepatosplenomegaly (HP:0001433)2.20025697
105Keratoconjunctivitis (HP:0001096)2.19931915
106Congenital sensorineural hearing impairment (HP:0008527)2.19366532
107Arterial thrombosis (HP:0004420)2.19024658
108Large for gestational age (HP:0001520)2.18279913
109Recurrent lower respiratory tract infections (HP:0002783)2.15930800
110Vasculitis (HP:0002633)2.15642732
111Congenital, generalized hypertrichosis (HP:0004540)2.15145028
112J-shaped sella turcica (HP:0002680)2.11986955
113Spontaneous hematomas (HP:0007420)2.11344689
114Aplasia/Hypoplasia of the tongue (HP:0010295)2.10000841
115Congenital hepatic fibrosis (HP:0002612)2.09609838
116Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09323718
117Osteomyelitis (HP:0002754)2.07299174
118Mutism (HP:0002300)2.07284901
119Premature loss of primary teeth (HP:0006323)2.07165029
120Leukocytosis (HP:0001974)2.06558602
121Bony spicule pigmentary retinopathy (HP:0007737)2.06223834
122Prolonged neonatal jaundice (HP:0006579)2.05677229
123Abnormality of the pons (HP:0007361)2.04870975
124Sclerocornea (HP:0000647)2.04036541
125Complement deficiency (HP:0004431)2.02550158
126Agnosia (HP:0010524)2.02486915
127Pulmonary infiltrates (HP:0002113)2.01889742
128Medial flaring of the eyebrow (HP:0010747)2.01838901
129Progressive visual loss (HP:0000529)2.00737261
130Cellulitis (HP:0100658)1.99566668
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98857529
132Abnormality of polysaccharide metabolism (HP:0011012)1.98857529
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98857529
134Granulocytopenia (HP:0001913)1.97840130
135Plantar hyperkeratosis (HP:0007556)1.97824497
136Encephalitis (HP:0002383)1.96924974
137Hypoplasia of the pons (HP:0012110)1.95358071
138Severe visual impairment (HP:0001141)1.95248798
139Elevated erythrocyte sedimentation rate (HP:0003565)1.95211051
140Abnormality of the ischium (HP:0003174)1.94770766
141Urethral obstruction (HP:0000796)1.94696827
142Mucopolysacchariduria (HP:0008155)1.93936878
143Urinary glycosaminoglycan excretion (HP:0003541)1.93936878
144Birth length less than 3rd percentile (HP:0003561)1.93016151
145Abnormality of eosinophils (HP:0001879)1.91208690
146Palmoplantar hyperkeratosis (HP:0000972)1.91187834
147Petechiae (HP:0000967)1.90386798
148Chorioretinal atrophy (HP:0000533)1.90192069
149Stomatitis (HP:0010280)1.89486429
150Gastrointestinal inflammation (HP:0004386)1.89347680
151Abnormality of the prostate (HP:0008775)1.88475841
152Agammaglobulinemia (HP:0004432)1.86721137
153Lissencephaly (HP:0001339)1.86243941
154Macroglossia (HP:0000158)1.85544761
155Keratoconjunctivitis sicca (HP:0001097)1.85512309
156Pathologic fracture (HP:0002756)1.81008439
157Cerebellar dysplasia (HP:0007033)1.80891626
158Abnormality of renin-angiotensin system (HP:0000847)1.80078246
159Submucous cleft hard palate (HP:0000176)1.79995810
160Polyuria (HP:0000103)1.79921125
161Clubbing of toes (HP:0100760)1.79398861
162Severe muscular hypotonia (HP:0006829)1.79091482
163Arterial tortuosity (HP:0005116)1.78718006
164IgM deficiency (HP:0002850)1.78489620
165Renal cortical cysts (HP:0000803)1.78410580
166Ectropion (HP:0000656)1.76358318
167Bone pain (HP:0002653)1.75733985
168Anencephaly (HP:0002323)1.75512858
169Thoracic kyphosis (HP:0002942)1.74959620
170Abnormality of complement system (HP:0005339)1.74693009
171Upper limb muscle weakness (HP:0003484)1.72868480
172Hyperkalemia (HP:0002153)1.71646295
173Chronic otitis media (HP:0000389)1.71048976
174Palmar hyperkeratosis (HP:0010765)1.70764334
175Aplasia cutis congenita (HP:0001057)1.69984229
176Acute lymphatic leukemia (HP:0006721)1.69488931
177Bile duct proliferation (HP:0001408)1.69174995
178Abnormal biliary tract physiology (HP:0012439)1.69174995
179Male pseudohermaphroditism (HP:0000037)1.68996076
180Tetraparesis (HP:0002273)1.68872821
181Aplasia/Hypoplasia of the uvula (HP:0010293)1.67679773
182Abnormal trabecular bone morphology (HP:0100671)1.66685388
183Leukopenia (HP:0001882)1.65696854
184Abnormality of nail color (HP:0100643)1.65530933
185Cone-rod dystrophy (HP:0000548)1.64739900
186Abnormality of the renal collecting system (HP:0004742)1.62836399
187Duplicated collecting system (HP:0000081)1.61234120
188Absent speech (HP:0001344)1.60503302
189Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59711143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.12882624
2ACVR1B4.00673691
3IRAK33.72799361
4MAP3K143.67123829
5IRAK43.05757008
6BLK2.92475797
7TYK22.92156127
8IKBKB2.32560733
9RIPK42.31422891
10CSF1R2.18743602
11CAMK1D2.11726627
12MAPKAPK32.11444815
13WNK42.09761328
14GRK72.05848574
15MAPK152.02208220
16TLK11.94595333
17ZAK1.93764328
18TBK11.91161001
19TXK1.90080588
20JAK31.89402925
21JAK11.89016576
22PIK3CA1.88012041
23ADRBK11.81385501
24EIF2AK21.77509766
25TNK21.76576133
26TSSK61.69627114
27IKBKE1.60004019
28OXSR11.59047595
29CHUK1.58678159
30KIT1.53594519
31MAP4K11.52538259
32MAP3K131.52316532
33TGFBR11.52078425
34PLK41.50539960
35GRK11.45774877
36DAPK21.39333763
37ZAP701.35894130
38NUAK11.33156328
39MAP3K31.32508278
40GRK61.28823009
41STK31.28472220
42CDK31.23960159
43NEK91.20291616
44MUSK1.19027160
45AKT31.18861584
46NME21.16098954
47STK101.13803409
48MAP4K21.13182623
49PTK2B1.11853622
50MKNK21.08526076
51TRPM71.07236650
52PRKAA21.06634545
53RPS6KA61.05743777
54CSK1.05119027
55STK38L1.04182963
56EPHB11.03604658
57TAOK31.01509484
58CAMK1G1.00690344
59CLK10.99170754
60HCK0.97428044
61MARK30.96563345
62TEC0.95752222
63SIK20.95414464
64MAPK130.93554766
65STK390.92470487
66PINK10.90657190
67MAP2K30.90552775
68YES10.89510829
69BTK0.88475186
70LYN0.87017517
71PRKCE0.86547675
72PIM10.85682921
73NLK0.84019715
74RPS6KA40.79621942
75PAK30.79544573
76LCK0.79249293
77STK240.78257708
78ADRBK20.78243120
79JAK20.76747074
80PIK3CG0.76029472
81STK380.74493461
82EPHA20.73699039
83MAP2K60.73501328
84SYK0.73248222
85WNK30.72099383
86EPHA30.71876285
87FER0.70532526
88IRAK10.70516019
89BMPR20.69251262
90FGFR30.67327861
91CDK120.66700785
92VRK10.65835097
93STK40.65681944
94MAP2K10.65066784
95PRKCQ0.64927445
96RPS6KA20.63644438
97MAPKAPK20.62484533
98MKNK10.61553123
99STK160.61212777
100PRKCI0.60352278
101CDK80.58086023
102WNK10.57747947
103ABL10.55531466
104TIE10.54319075
105LATS10.53509187
106PTK60.52603785
107FGR0.52496603
108MYLK0.51314344
109PAK40.50399114
110TTK0.50392318
111PRKD20.50258219
112CDC42BPA0.49906311
113NEK20.49542834
114CDK190.46634460
115PNCK0.46566838
116ITK0.46280812
117MAP3K70.46183960
118PKN10.46000061
119SRPK10.45894092
120BMPR1B0.45820448
121FGFR40.45762333
122MAP2K20.45254788
123FES0.44882870
124NEK60.44670979
125PDK10.44000750
126CAMKK20.43620222
127PRKCD0.43310417
128FLT30.43000277
129CDK40.42350938
130RPS6KL10.42188460
131RPS6KC10.42188460
132ERBB20.41643117
133CDK90.40693532
134PDPK10.39856455
135ERN10.39793160
136MELK0.38096207
137CAMK10.36899283
138PRKCG0.36456042
139FRK0.36127615
140MST40.35732852
141MATK0.35452903
142PDGFRB0.35320471
143PRKCA0.34402837
144HIPK20.34320502
145INSRR0.33414677
146SGK20.32727915
147PLK30.32411065
148IGF1R0.31977005
149MAPK120.31613664
150PRKCZ0.31066660
151MAPKAPK50.30352627
152SGK30.29999951
153STK110.29431726
154CAMKK10.29140375

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.03557925
2Linoleic acid metabolism_Homo sapiens_hsa005912.97034142
3Staphylococcus aureus infection_Homo sapiens_hsa051502.83126034
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.75803208
5Other glycan degradation_Homo sapiens_hsa005112.72546278
6Nitrogen metabolism_Homo sapiens_hsa009102.63383386
7Leishmaniasis_Homo sapiens_hsa051402.53120166
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.49287595
9Osteoclast differentiation_Homo sapiens_hsa043802.37099176
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.33834688
11Phototransduction_Homo sapiens_hsa047442.30381690
12Lysosome_Homo sapiens_hsa041422.29240695
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24303514
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.14188679
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09216945
16Measles_Homo sapiens_hsa051621.97661351
17Antigen processing and presentation_Homo sapiens_hsa046121.88978546
18Selenocompound metabolism_Homo sapiens_hsa004501.85044874
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82349073
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78057360
21Pertussis_Homo sapiens_hsa051331.74080129
22Tuberculosis_Homo sapiens_hsa051521.66022789
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64665133
24Legionellosis_Homo sapiens_hsa051341.64048494
25Toxoplasmosis_Homo sapiens_hsa051451.62581465
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60521584
27Tryptophan metabolism_Homo sapiens_hsa003801.60514620
28Vitamin B6 metabolism_Homo sapiens_hsa007501.60252349
29Influenza A_Homo sapiens_hsa051641.59697482
30Hematopoietic cell lineage_Homo sapiens_hsa046401.58117013
31Graft-versus-host disease_Homo sapiens_hsa053321.54736000
32B cell receptor signaling pathway_Homo sapiens_hsa046621.50409069
33Rheumatoid arthritis_Homo sapiens_hsa053231.50119537
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49483286
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48012920
36Herpes simplex infection_Homo sapiens_hsa051681.46916400
37Type I diabetes mellitus_Homo sapiens_hsa049401.39928044
38Caffeine metabolism_Homo sapiens_hsa002321.36227410
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34123829
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33783884
41Allograft rejection_Homo sapiens_hsa053301.32593086
42TNF signaling pathway_Homo sapiens_hsa046681.31317375
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31297914
44Apoptosis_Homo sapiens_hsa042101.30230178
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.29967444
46Glycerolipid metabolism_Homo sapiens_hsa005611.27108765
47Malaria_Homo sapiens_hsa051441.25475099
48Butanoate metabolism_Homo sapiens_hsa006501.21849336
49Taste transduction_Homo sapiens_hsa047421.20380333
50Ovarian steroidogenesis_Homo sapiens_hsa049131.19584331
51Primary immunodeficiency_Homo sapiens_hsa053401.18564911
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.18252951
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16610771
54Chemokine signaling pathway_Homo sapiens_hsa040621.15592891
55Morphine addiction_Homo sapiens_hsa050321.13561209
56Sphingolipid metabolism_Homo sapiens_hsa006001.13333436
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10796484
58Serotonergic synapse_Homo sapiens_hsa047261.09265597
59Phagosome_Homo sapiens_hsa041451.07549435
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07215832
61Vitamin digestion and absorption_Homo sapiens_hsa049771.05085765
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.03554703
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02638396
64Hepatitis B_Homo sapiens_hsa051611.01432212
65Olfactory transduction_Homo sapiens_hsa047401.00161591
66Asthma_Homo sapiens_hsa053100.99465677
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.99463071
68Fatty acid biosynthesis_Homo sapiens_hsa000610.97406334
69Prolactin signaling pathway_Homo sapiens_hsa049170.96218931
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95490071
71Autoimmune thyroid disease_Homo sapiens_hsa053200.94962305
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91163997
73Epstein-Barr virus infection_Homo sapiens_hsa051690.90716691
74Chemical carcinogenesis_Homo sapiens_hsa052040.89933941
75Histidine metabolism_Homo sapiens_hsa003400.89227605
76Dorso-ventral axis formation_Homo sapiens_hsa043200.89052214
77Nicotine addiction_Homo sapiens_hsa050330.86947585
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86112085
79Regulation of autophagy_Homo sapiens_hsa041400.86041003
80Hepatitis C_Homo sapiens_hsa051600.84948140
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.81879582
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.81478934
83Calcium signaling pathway_Homo sapiens_hsa040200.80349512
84Pancreatic cancer_Homo sapiens_hsa052120.79508469
85Salmonella infection_Homo sapiens_hsa051320.78887279
86Arachidonic acid metabolism_Homo sapiens_hsa005900.78397447
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78159763
88Acute myeloid leukemia_Homo sapiens_hsa052210.77469912
89Glutamatergic synapse_Homo sapiens_hsa047240.77466183
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76117323
91Circadian entrainment_Homo sapiens_hsa047130.75975568
92Small cell lung cancer_Homo sapiens_hsa052220.74178397
93p53 signaling pathway_Homo sapiens_hsa041150.73828769
94Chronic myeloid leukemia_Homo sapiens_hsa052200.73657498
95Salivary secretion_Homo sapiens_hsa049700.73518665
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73088343
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71770612
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71574600
99Fanconi anemia pathway_Homo sapiens_hsa034600.71086617
100Retinol metabolism_Homo sapiens_hsa008300.70313395
101RNA polymerase_Homo sapiens_hsa030200.68774334
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68624823
103African trypanosomiasis_Homo sapiens_hsa051430.68471609
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.67328706
105Fat digestion and absorption_Homo sapiens_hsa049750.66054094
106Lysine degradation_Homo sapiens_hsa003100.64494947
107Shigellosis_Homo sapiens_hsa051310.62277626
108Gastric acid secretion_Homo sapiens_hsa049710.61074754
109T cell receptor signaling pathway_Homo sapiens_hsa046600.61060986
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60677982
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60155156
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59894590
113Basal transcription factors_Homo sapiens_hsa030220.59804140
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59514454
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58439257
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58340622
117FoxO signaling pathway_Homo sapiens_hsa040680.58304825
118Ether lipid metabolism_Homo sapiens_hsa005650.57814189
119Insulin secretion_Homo sapiens_hsa049110.57658662
120Homologous recombination_Homo sapiens_hsa034400.57414414
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.57170880
122Pancreatic secretion_Homo sapiens_hsa049720.55826622
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54479226
124Mineral absorption_Homo sapiens_hsa049780.53364323
125Sulfur metabolism_Homo sapiens_hsa009200.52997816
126Non-homologous end-joining_Homo sapiens_hsa034500.52754672
127ABC transporters_Homo sapiens_hsa020100.52634961
128Inositol phosphate metabolism_Homo sapiens_hsa005620.50258284
129Galactose metabolism_Homo sapiens_hsa000520.50032785
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49727813
131Viral myocarditis_Homo sapiens_hsa054160.48626948
132Oxytocin signaling pathway_Homo sapiens_hsa049210.47634996
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46244156
134Long-term depression_Homo sapiens_hsa047300.46105949
135GABAergic synapse_Homo sapiens_hsa047270.45348515
136Cholinergic synapse_Homo sapiens_hsa047250.44578502
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44361585
138Amoebiasis_Homo sapiens_hsa051460.44207966
139Notch signaling pathway_Homo sapiens_hsa043300.43684900
140HTLV-I infection_Homo sapiens_hsa051660.42404061
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42124208
142Prion diseases_Homo sapiens_hsa050200.40686267
143Endocytosis_Homo sapiens_hsa041440.39403849
144Platelet activation_Homo sapiens_hsa046110.38786457
145Adherens junction_Homo sapiens_hsa045200.38576898
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38455575
147Sulfur relay system_Homo sapiens_hsa041220.38137844
148Peroxisome_Homo sapiens_hsa041460.37964345
149Collecting duct acid secretion_Homo sapiens_hsa049660.37910849
150Prostate cancer_Homo sapiens_hsa052150.36240353
151Viral carcinogenesis_Homo sapiens_hsa052030.35635818
152MicroRNAs in cancer_Homo sapiens_hsa052060.35542114
153Complement and coagulation cascades_Homo sapiens_hsa046100.33242431
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32820034
155Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31482923
156Renin-angiotensin system_Homo sapiens_hsa046140.30508847

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