KCNK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingoid metabolic process (GO:0046519)7.89072051
2keratinocyte proliferation (GO:0043616)6.98994469
3establishment of skin barrier (GO:0061436)6.45456153
4regulation of ruffle assembly (GO:1900027)6.20982745
5regulation of water loss via skin (GO:0033561)6.02928409
6sphingosine metabolic process (GO:0006670)5.63198763
7diol metabolic process (GO:0034311)5.58869345
8response to peptidoglycan (GO:0032494)5.07035498
9negative regulation of stress fiber assembly (GO:0051497)4.89488922
10gap junction assembly (GO:0016264)4.84922847
11viral transcription (GO:0019083)4.70875827
12positive regulation by symbiont of host defense response (GO:0052509)4.70204021
13modulation by symbiont of host defense response (GO:0052031)4.70204021
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.70204021
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.70204021
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.70204021
17modulation by symbiont of host immune response (GO:0052553)4.70204021
18thymic T cell selection (GO:0045061)4.69676546
19detection of external biotic stimulus (GO:0098581)4.69653421
20keratinocyte differentiation (GO:0030216)4.69270972
21positive thymic T cell selection (GO:0045059)4.51164075
22translational termination (GO:0006415)4.49002427
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.41389128
24ribosomal small subunit biogenesis (GO:0042274)4.40067901
25keratinization (GO:0031424)4.31714599
26positive regulation of gamma-delta T cell activation (GO:0046645)4.31089626
27leukocyte aggregation (GO:0070486)4.29057111
28cellular response to interleukin-15 (GO:0071350)4.25509503
29regulation of chemokine secretion (GO:0090196)4.24632563
30macrophage activation involved in immune response (GO:0002281)4.23419119
31long-chain fatty acid biosynthetic process (GO:0042759)4.21736483
32negative regulation of cell killing (GO:0031342)4.19840371
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.19840371
34lipoxygenase pathway (GO:0019372)4.18503427
35response to muramyl dipeptide (GO:0032495)4.15966551
36neutrophil activation involved in immune response (GO:0002283)4.15701634
37detection of molecule of bacterial origin (GO:0032490)4.14243276
38detection of biotic stimulus (GO:0009595)4.11874938
39heterotypic cell-cell adhesion (GO:0034113)4.06423943
40negative regulation of erythrocyte differentiation (GO:0045647)4.02451932
41positive regulation of chemokine secretion (GO:0090197)4.01484159
42hemidesmosome assembly (GO:0031581)3.98057212
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.97875968
44regulation of phospholipase A2 activity (GO:0032429)3.95164059
45multicellular organismal water homeostasis (GO:0050891)3.94680042
46T-helper cell differentiation (GO:0042093)3.88096569
47CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.88096569
48positive regulation of interleukin-8 secretion (GO:2000484)3.85499980
49regulation of interferon-beta biosynthetic process (GO:0045357)3.82649178
50interferon-gamma secretion (GO:0072643)3.82197847
51homeostasis of number of cells within a tissue (GO:0048873)3.80969803
52negative regulation of interleukin-12 production (GO:0032695)3.79781468
53T cell selection (GO:0045058)3.79096848
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.76057446
55germinal center formation (GO:0002467)3.74750913
56positive regulation of interleukin-4 production (GO:0032753)3.74054744
57cellular extravasation (GO:0045123)3.73086416
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58565012
59positive T cell selection (GO:0043368)3.57680177
60cellular protein complex disassembly (GO:0043624)3.57083710
61response to interleukin-15 (GO:0070672)3.57044708
62protein targeting to ER (GO:0045047)3.55517744
63negative regulation of toll-like receptor signaling pathway (GO:0034122)3.54456090
64glucosamine-containing compound catabolic process (GO:1901072)3.53740319
65cotranslational protein targeting to membrane (GO:0006613)3.53492542
66translational elongation (GO:0006414)3.53252900
67negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.50330287
68T cell migration (GO:0072678)3.50163003
69regulation of T cell receptor signaling pathway (GO:0050856)3.49017320
70T cell receptor signaling pathway (GO:0050852)3.48858706
71regulation of gamma-delta T cell differentiation (GO:0045586)3.48185957
72regulation of B cell receptor signaling pathway (GO:0050855)3.47804715
73antigen processing and presentation of endogenous antigen (GO:0019883)3.47797635
74epidermal cell differentiation (GO:0009913)3.47646057
75viral life cycle (GO:0019058)3.47349271
76regulation of gamma-delta T cell activation (GO:0046643)3.47064297
77keratinocyte development (GO:0003334)3.45786039
78establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44550768
79barbed-end actin filament capping (GO:0051016)3.41264350
80neutrophil activation (GO:0042119)3.40613480
81granulocyte activation (GO:0036230)3.40540569
82T cell differentiation involved in immune response (GO:0002292)3.40532028
83alpha-beta T cell differentiation involved in immune response (GO:0002293)3.40532028
84alpha-beta T cell activation involved in immune response (GO:0002287)3.40532028
85negative regulation of cell fate specification (GO:0009996)3.38224982
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36752202
87negative regulation of actin filament bundle assembly (GO:0032232)3.35883917
88negative thymic T cell selection (GO:0045060)3.35742287
89protein localization to endoplasmic reticulum (GO:0070972)3.33923058
90epithelial cell differentiation involved in prostate gland development (GO:0060742)3.33473773
91regulation of interleukin-8 secretion (GO:2000482)3.33035407
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31813964
93leukocyte migration involved in inflammatory response (GO:0002523)3.30913243
94negative T cell selection (GO:0043383)3.30856429
95sequestering of actin monomers (GO:0042989)3.27956238
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26838699
97response to host immune response (GO:0052572)3.26838699
98negative regulation of T cell receptor signaling pathway (GO:0050860)3.22394095
99peptide cross-linking (GO:0018149)3.22373152
100water homeostasis (GO:0030104)3.22338964
101bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21899443
102negative regulation of lymphocyte mediated immunity (GO:0002707)3.21596122
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19260054
104hair cycle (GO:0042633)3.18072460
105molting cycle (GO:0042303)3.18072460
106negative regulation of interleukin-8 production (GO:0032717)3.17759174
107regulation of T-helper 2 cell differentiation (GO:0045628)3.17497155
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.17403501
109detection of bacterium (GO:0016045)3.15636878
110ribosomal large subunit biogenesis (GO:0042273)3.14600949
111positive regulation of tolerance induction (GO:0002645)3.13058676
112negative regulation of interleukin-6 production (GO:0032715)3.12736649
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10040646
114myeloid cell activation involved in immune response (GO:0002275)3.09417447
115macrophage activation (GO:0042116)3.08810977
116negative regulation of T cell mediated immunity (GO:0002710)3.05317963
117regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04898611
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04877402
119response to host (GO:0075136)3.04877402
120response to host defenses (GO:0052200)3.04877402
121interferon-gamma production (GO:0032609)3.04626927
122regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03891737
123lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02308233
124negative regulation of B cell mediated immunity (GO:0002713)3.01536618
125negative regulation of immunoglobulin mediated immune response (GO:0002890)3.01536618
126antigen receptor-mediated signaling pathway (GO:0050851)3.01181254
127fatty acid elongation (GO:0030497)3.01077441
128regulation of mast cell degranulation (GO:0043304)3.00946844
129membrane raft organization (GO:0031579)3.00139918
130epidermis development (GO:0008544)2.99888954
131negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.98958350
132regulation of interleukin-4 production (GO:0032673)2.98843251
133regulation of glomerular filtration (GO:0003093)2.98745856
134maturation of SSU-rRNA (GO:0030490)2.96762950
135neutrophil mediated immunity (GO:0002446)2.96283966
136negative regulation of kidney development (GO:0090185)2.95750487
137regulation of toll-like receptor signaling pathway (GO:0034121)2.94502678
138G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.93739058
139positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93315516
140negative regulation of leukocyte mediated immunity (GO:0002704)2.92646539
141regulation of hypersensitivity (GO:0002883)2.91818985
142linoleic acid metabolic process (GO:0043651)2.91244240
143protein complex disassembly (GO:0043241)2.90531134
144respiratory burst (GO:0045730)2.90355045
145negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89604192
146detection of other organism (GO:0098543)2.89162398
147sphingolipid biosynthetic process (GO:0030148)2.88923740
148regulation of leukocyte degranulation (GO:0043300)2.88464849
149regulation of cell proliferation involved in kidney development (GO:1901722)2.88070521
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86163494
151defense response to protozoan (GO:0042832)2.80186055
152regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79657169
153immunoglobulin mediated immune response (GO:0016064)2.78849613
154regulation of natural killer cell differentiation (GO:0032823)2.76842206
155negative regulation of innate immune response (GO:0045824)2.74174099
156regulation of mast cell activation involved in immune response (GO:0033006)2.71697484
157positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70521152
158microglial cell activation (GO:0001774)2.67586932
159positive regulation of cellular amide metabolic process (GO:0034250)2.66362029
160T-helper 1 type immune response (GO:0042088)2.66200180
161negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.65347350
162negative regulation of tumor necrosis factor production (GO:0032720)2.63881424
163type I interferon signaling pathway (GO:0060337)2.61697438
164cellular response to type I interferon (GO:0071357)2.61697438
165regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.60766658
166response to type I interferon (GO:0034340)2.60555710
167phosphatidylinositol acyl-chain remodeling (GO:0036149)2.59713551
168leukocyte degranulation (GO:0043299)2.59248978
169regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.58619156
170negative regulation of interleukin-17 production (GO:0032700)2.58598362
171negative regulation of T-helper cell differentiation (GO:0045623)2.58220209
172negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.58220209
173negative regulation of cytokine production involved in immune response (GO:0002719)2.57629128
174regulation of interleukin-6 production (GO:0032675)2.56965829
175NIK/NF-kappaB signaling (GO:0038061)2.55858793
176regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55837980
177desmosome organization (GO:0002934)11.6127864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.83017165
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.06720139
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.98870841
4VDR_21846776_ChIP-Seq_THP-1_Human3.42377321
5SRY_22984422_ChIP-ChIP_TESTIS_Rat3.03760943
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.59039905
7* VDR_24763502_ChIP-Seq_THP-1_Human2.55524623
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48455610
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44504808
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43842707
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33583182
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24555168
13SOX9_24532713_ChIP-Seq_HFSC_Mouse2.22371225
14TCF7_22412390_ChIP-Seq_EML_Mouse2.19864644
15KDM2B_26808549_Chip-Seq_DND41_Human2.14151362
16MYC_22102868_ChIP-Seq_BL_Human2.14064962
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.02105539
18TP63_17297297_ChIP-ChIP_HaCaT_Human14.0658588
19STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98560092
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93281340
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93090288
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.89497022
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.86876444
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86560139
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83150179
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82846198
27* IRF8_27001747_Chip-Seq_BMDM_Mouse1.82815560
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80437493
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75935957
30P68_20966046_ChIP-Seq_HELA_Human1.72955062
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65413500
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65413500
33BCL6_27268052_Chip-Seq_Bcells_Human1.64929751
34RUNX_20019798_ChIP-Seq_JUKART_Human1.64781273
35SCL_19346495_ChIP-Seq_HPC-7_Human1.63827988
36MAF_26560356_Chip-Seq_TH1_Human1.61115445
37BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.60995696
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57018315
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.56956444
40MYB_26560356_Chip-Seq_TH2_Human1.54502941
41SPI1_23547873_ChIP-Seq_NB4_Human1.50060976
42SPI1_23127762_ChIP-Seq_K562_Human1.49313543
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.49223188
44KDM2B_26808549_Chip-Seq_K562_Human1.48940851
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.40831222
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39616962
47UTX_26944678_Chip-Seq_JUKART_Human1.36891942
48SMC4_20622854_ChIP-Seq_HELA_Human1.36029075
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34413289
50E2F1_20622854_ChIP-Seq_HELA_Human1.32527649
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32359601
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32304568
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31766423
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.29266174
55* SA1_27219007_Chip-Seq_ERYTHROID_Human1.29041441
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28944616
57* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28852339
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.28686601
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.27730630
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.27358108
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25311824
62SOX2_20726797_ChIP-Seq_SW620_Human1.25200889
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.25190935
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23272016
65GATA1_19941826_ChIP-Seq_K562_Human1.22980507
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22557268
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.21947820
68MYB_26560356_Chip-Seq_TH1_Human1.21411390
69SA1_27219007_Chip-Seq_Bcells_Human1.21240154
70AR_21572438_ChIP-Seq_LNCaP_Human1.21199986
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20805056
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20598396
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18542455
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17026713
75* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15839208
76CREB1_26743006_Chip-Seq_LNCaP_Human1.15563486
77* MAF_26560356_Chip-Seq_TH2_Human1.14885326
78EGR1_19032775_ChIP-ChIP_M12_Human1.14014897
79CEBPB_22108803_ChIP-Seq_LS180_Human1.13986973
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13750730
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13634747
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13022331
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11927448
84* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11400449
85* TP63_22573176_ChIP-Seq_HFKS_Human1.09578851
86* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09101047
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08634461
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07815189
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07164820
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07053188
91NCOR1_26117541_ChIP-Seq_K562_Human1.05373456
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.05349067
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04732100
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04546203
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04124705
96LXR_22292898_ChIP-Seq_THP-1_Human1.03131800
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.02902886
98CTCF_27219007_Chip-Seq_Bcells_Human1.02678207
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00581374
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99614446
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.98385856
102RUNX1_22412390_ChIP-Seq_EML_Mouse0.97508946
103GATA6_21074721_ChIP-Seq_CACO-2_Human0.95161924
104* TP63_23658742_ChIP-Seq_EP156T_Human0.95157592
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94574436
106VDR_22108803_ChIP-Seq_LS180_Human0.94258270
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90739330
108CJUN_26792858_Chip-Seq_BT549_Human0.90188334
109RACK7_27058665_Chip-Seq_MCF-7_Human0.90187112
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89407784
111NANOG_20526341_ChIP-Seq_ESCs_Human0.88621775
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87692251
113* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86641014
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86584305
115RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86332031
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.85810256
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84215862
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83905480
119GATA4_25053715_ChIP-Seq_YYC3_Human0.83265444
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83089065
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79317541
122IRF8_21731497_ChIP-ChIP_J774_Mouse0.78801719
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.78316094
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78053429
125RUNX1_27514584_Chip-Seq_MCF-7_Human0.77867261
126BCOR_27268052_Chip-Seq_Bcells_Human0.77696165
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.77383922
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77169197
129* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77144452
130KLF5_25053715_ChIP-Seq_YYC3_Human0.75556933
131TP53_18474530_ChIP-ChIP_U2OS_Human0.75434122
132GATA3_27048872_Chip-Seq_THYMUS_Human0.75302560
133* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74214577
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74005892
135SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73940955
136* ELK3_25401928_ChIP-Seq_HUVEC_Human0.73899463
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73554271
138GATA6_25053715_ChIP-Seq_YYC3_Human0.73242555
139PHF8_20622854_ChIP-Seq_HELA_Human0.71293252
140VDR_24787735_ChIP-Seq_THP-1_Human0.71222514
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70373316
142CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.70221933
143ATF3_27146783_Chip-Seq_COLON_Human0.70141101
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69974506
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69763983
146ZNF263_19887448_ChIP-Seq_K562_Human0.69101548
147E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.68747654
148CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67998667
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.67154509
150TBX20_22080862_ChIP-Seq_HEART_Mouse0.66876940
151TBX20_22328084_ChIP-Seq_HEART_Mouse0.66876940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.10729693
2MP0003941_abnormal_skin_development4.94187079
3MP0002009_preneoplasia4.58769577
4MP0010234_abnormal_vibrissa_follicle3.54233244
5MP0003303_peritoneal_inflammation3.38156154
6MP0005501_abnormal_skin_physiology3.32222717
7MP0003453_abnormal_keratinocyte_physiol3.20641247
8MP0004381_abnormal_hair_follicle3.16411195
9MP0000566_synostosis2.96287683
10MP0003763_abnormal_thymus_physiology2.83440031
11MP0002166_altered_tumor_susceptibility2.79945688
12MP0002006_tumorigenesis2.71991118
13MP0004947_skin_inflammation2.71209806
14MP0000383_abnormal_hair_follicle2.68118038
15MP0001216_abnormal_epidermal_layer2.63862545
16MP0002254_reproductive_system_inflammat2.62688854
17MP0003191_abnormal_cellular_cholesterol2.49498893
18MP0000685_abnormal_immune_system2.46568651
19MP0002060_abnormal_skin_morphology2.46520459
20MP0005671_abnormal_response_to2.41263873
21MP0000015_abnormal_ear_pigmentation2.26780061
22MP0002098_abnormal_vibrissa_morphology2.24670335
23MP0005275_abnormal_skin_tensile2.21867629
24MP0000467_abnormal_esophagus_morphology2.19743863
25MP0010771_integument_phenotype2.14405556
26MP0000377_abnormal_hair_follicle2.08544437
27MP0009379_abnormal_foot_pigmentation2.02948567
28MP0002234_abnormal_pharynx_morphology1.99731741
29MP0010678_abnormal_skin_adnexa1.95075695
30MP0003300_gastrointestinal_ulcer1.86981605
31MP0010352_gastrointestinal_tract_polyps1.84363483
32MP0005000_abnormal_immune_tolerance1.82985764
33MP0002933_joint_inflammation1.76470272
34MP0000579_abnormal_nail_morphology1.75967542
35MP0003705_abnormal_hypodermis_morpholog1.70995429
36MP0001188_hyperpigmentation1.66728161
37MP0008260_abnormal_autophagy1.66566913
38MP0005451_abnormal_body_composition1.66343841
39MP0009278_abnormal_bone_marrow1.65974213
40MP0001790_abnormal_immune_system1.65511209
41MP0005387_immune_system_phenotype1.65511209
42MP0005409_darkened_coat_color1.63719424
43MP0002405_respiratory_system_inflammati1.63186240
44MP0001800_abnormal_humoral_immune1.61170105
45MP0001835_abnormal_antigen_presentation1.57690615
46MP0003566_abnormal_cell_adhesion1.57046652
47MP0003315_abnormal_perineum_morphology1.55243986
48MP0001243_abnormal_dermal_layer1.54149274
49MP0002723_abnormal_immune_serum1.52423988
50MP0001346_abnormal_lacrimal_gland1.52244580
51MP0009785_altered_susceptibility_to1.47750168
52MP0002148_abnormal_hypersensitivity_rea1.47386760
53MP0001191_abnormal_skin_condition1.46780931
54MP0003436_decreased_susceptibility_to1.45800285
55MP0000647_abnormal_sebaceous_gland1.45101737
56MP0000537_abnormal_urethra_morphology1.44627798
57MP0002420_abnormal_adaptive_immunity1.42810776
58MP0005025_abnormal_response_to1.42325116
59MP0009384_cardiac_valve_regurgitation1.41913123
60MP0001819_abnormal_immune_cell1.40420236
61MP0001851_eye_inflammation1.38722330
62MP0003724_increased_susceptibility_to1.35735063
63MP0009931_abnormal_skin_appearance1.35555455
64MP0003172_abnormal_lysosome_physiology1.34683147
65MP0005171_absent_coat_pigmentation1.31513970
66MP0002452_abnormal_antigen_presenting1.30244090
67MP0005076_abnormal_cell_differentiation1.27579955
68MP0000427_abnormal_hair_cycle1.24321274
69MP0005023_abnormal_wound_healing1.22108421
70MP0005058_abnormal_lysosome_morphology1.20843863
71MP0003011_delayed_dark_adaptation1.20197102
72MP0000465_gastrointestinal_hemorrhage1.18351553
73MP0005464_abnormal_platelet_physiology1.18026229
74MP0010155_abnormal_intestine_physiology1.16380166
75MP0000703_abnormal_thymus_morphology1.16228893
76MP0001986_abnormal_taste_sensitivity1.15320206
77MP0003075_altered_response_to1.14953716
78MP0002998_abnormal_bone_remodeling1.14836704
79MP0003878_abnormal_ear_physiology1.14650503
80MP0005377_hearing/vestibular/ear_phenot1.14650503
81MP0002132_abnormal_respiratory_system1.13257065
82MP0000367_abnormal_coat/_hair1.13012491
83MP0006082_CNS_inflammation1.11880358
84MP0005075_abnormal_melanosome_morpholog1.11158416
85MP0002398_abnormal_bone_marrow1.07865834
86MP0008004_abnormal_stomach_pH1.07263380
87MP0002722_abnormal_immune_system1.05758438
88MP0001853_heart_inflammation1.04870631
89MP0009840_abnormal_foam_cell1.04465515
90MP0009764_decreased_sensitivity_to1.03262222
91MP0000762_abnormal_tongue_morphology1.00622066
92MP0001873_stomach_inflammation1.00070442
93MP0000716_abnormal_immune_system0.97437657
94MP0005397_hematopoietic_system_phenotyp0.95289416
95MP0001545_abnormal_hematopoietic_system0.95289416
96MP0002653_abnormal_ependyma_morphology0.92353017
97MP0000858_altered_metastatic_potential0.92288074
98MP0005174_abnormal_tail_pigmentation0.91194263
99MP0002419_abnormal_innate_immunity0.87054432
100MP0003866_abnormal_defecation0.85196189
101MP0000750_abnormal_muscle_regeneration0.83979985
102MP0008469_abnormal_protein_level0.83619466
103MP0001340_abnormal_eyelid_morphology0.83301031
104MP0001845_abnormal_inflammatory_respons0.82957732
105MP0004130_abnormal_muscle_cell0.80946220
106MP0000627_abnormal_mammary_gland0.80870117
107MP0001984_abnormal_olfaction0.80285707
108MP0002095_abnormal_skin_pigmentation0.77888591
109MP0000689_abnormal_spleen_morphology0.74657788
110MP0003828_pulmonary_edema0.73763499
111MP0004185_abnormal_adipocyte_glucose0.71863564
112MP0005310_abnormal_salivary_gland0.71129262
113MP0002429_abnormal_blood_cell0.70255358
114MP0003448_altered_tumor_morphology0.68964724
115MP0000538_abnormal_urinary_bladder0.68411846
116MP0005390_skeleton_phenotype0.67932281
117MP0002277_abnormal_respiratory_mucosa0.65383337
118MP0003329_amyloid_beta_deposits0.65009666
119MP0002332_abnormal_exercise_endurance0.64650274
120MP0004510_myositis0.64604723
121MP0005166_decreased_susceptibility_to0.63127725
122MP0009333_abnormal_splenocyte_physiolog0.61466739
123MP0000613_abnormal_salivary_gland0.59542882
124MP0010386_abnormal_urinary_bladder0.56326994
125MP0003045_fibrosis0.56178457
126MP0002177_abnormal_outer_ear0.55800694
127MP0001533_abnormal_skeleton_physiology0.54652363
128MP0004782_abnormal_surfactant_physiolog0.53699904
129MP0005623_abnormal_meninges_morphology0.49933241
130MP0000604_amyloidosis0.49611906
131MP0005165_increased_susceptibility_to0.49584712

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)6.24969728
2Stomatitis (HP:0010280)5.85528861
3Parakeratosis (HP:0001036)5.06053161
4Woolly hair (HP:0002224)4.78675607
5Hypotrichosis (HP:0001006)4.76456163
6Abnormality of the axillary hair (HP:0100134)4.44467072
7Abnormality of secondary sexual hair (HP:0009888)4.44467072
8Popliteal pterygium (HP:0009756)4.31600241
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.13331189
10Congenital ichthyosiform erythroderma (HP:0007431)4.03395378
11Thick nail (HP:0001805)3.94123444
12Erythema (HP:0010783)3.88031045
13Conjunctival hamartoma (HP:0100780)3.71491322
14Gangrene (HP:0100758)3.69226534
15Right ventricular cardiomyopathy (HP:0011663)3.65667989
16Autoimmune hemolytic anemia (HP:0001890)3.63100386
17Abnormality of macrophages (HP:0004311)3.62815391
18Pustule (HP:0200039)3.62786703
19Plantar hyperkeratosis (HP:0007556)3.56440152
20Abnormal blistering of the skin (HP:0008066)3.33484919
21Abnormality of cells of the erythroid lineage (HP:0012130)3.33398088
22Nasal polyposis (HP:0100582)3.28136748
23Ectropion (HP:0000656)3.20863911
24Alopecia of scalp (HP:0002293)3.15887416
25Increased IgE level (HP:0003212)3.13285649
26Abnormality of the salivary glands (HP:0010286)3.11393084
27Reticulocytopenia (HP:0001896)3.09177792
28Pruritus (HP:0000989)3.08593939
29Hyporeflexia of lower limbs (HP:0002600)3.05866730
30Severe combined immunodeficiency (HP:0004430)3.03566951
31Fragile nails (HP:0001808)3.02399594
32Elevated erythrocyte sedimentation rate (HP:0003565)2.99207264
33Urticaria (HP:0001025)2.97646889
34Keratoconjunctivitis sicca (HP:0001097)2.97284082
35Palmoplantar hyperkeratosis (HP:0000972)2.97282338
36Gastrointestinal infarctions (HP:0005244)2.91894311
37IgM deficiency (HP:0002850)2.91516294
38Abnormality of T cell physiology (HP:0011840)2.91208955
39Recurrent bronchitis (HP:0002837)2.86930279
40Sparse eyelashes (HP:0000653)2.84548270
41Recurrent sinusitis (HP:0011108)2.79667995
42Eczematoid dermatitis (HP:0000976)2.77722332
43Recurrent abscess formation (HP:0002722)2.74963809
44Corneal erosion (HP:0200020)2.74305912
45Keratoconjunctivitis (HP:0001096)2.74146666
46Milia (HP:0001056)2.73752914
47Abnormal hemoglobin (HP:0011902)2.72243715
48Palmar hyperkeratosis (HP:0010765)2.71948161
49Recurrent gram-negative bacterial infections (HP:0005420)2.68036519
50Abnormal number of erythroid precursors (HP:0012131)2.65270321
51Mediastinal lymphadenopathy (HP:0100721)2.64015213
52Petechiae (HP:0000967)2.61804848
53Abnormality of T cells (HP:0002843)2.61018355
54Pili torti (HP:0003777)2.60939887
55Abnormality of the nasal mucosa (HP:0000433)2.60416351
56Hypoplastic labia majora (HP:0000059)2.57470286
57Myositis (HP:0100614)2.54150610
58Combined immunodeficiency (HP:0005387)2.53444279
59Palmoplantar keratoderma (HP:0000982)2.49624939
60Distal lower limb muscle weakness (HP:0009053)2.46275812
61Macrocytic anemia (HP:0001972)2.45252658
62Erythroderma (HP:0001019)2.43617725
63Congenital, generalized hypertrichosis (HP:0004540)2.43360850
64Spontaneous hematomas (HP:0007420)2.42889299
65Onycholysis (HP:0001806)2.42264648
66Abnormality of nail color (HP:0100643)2.39585913
67Abnormal ciliary motility (HP:0012262)2.36669452
68Natal tooth (HP:0000695)2.30379893
69Obstructive lung disease (HP:0006536)2.30269321
70Chronic obstructive pulmonary disease (HP:0006510)2.30269321
71Nail dystrophy (HP:0008404)2.29670280
72Pterygium (HP:0001059)2.28296747
73Abnormality of the labia majora (HP:0012881)2.28183907
74Meningitis (HP:0001287)2.27807330
75Bifid scrotum (HP:0000048)2.27141724
76Congenital malformation of the right heart (HP:0011723)2.26276938
77Double outlet right ventricle (HP:0001719)2.26276938
78Ventricular tachycardia (HP:0004756)2.24739124
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.24211149
80Abnormality of glycolipid metabolism (HP:0010969)2.24211149
81Abnormality of liposaccharide metabolism (HP:0010968)2.24211149
82Gingivitis (HP:0000230)2.23856358
83Hypoplasia of the uterus (HP:0000013)2.22429552
84Hamartoma of the eye (HP:0010568)2.22194337
85Increased IgM level (HP:0003496)2.20077855
86Segmental peripheral demyelination/remyelination (HP:0003481)2.19807456
87Hypohidrosis (HP:0000966)2.16741621
88Fragile skin (HP:0001030)2.15692875
89Advanced eruption of teeth (HP:0006288)2.14625723
90Recurrent skin infections (HP:0001581)2.14590826
91Oral leukoplakia (HP:0002745)2.14365696
92Recurrent cutaneous fungal infections (HP:0011370)2.11578387
93Chronic mucocutaneous candidiasis (HP:0002728)2.11578387
94Pallor (HP:0000980)2.11300888
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08429686
96Paralysis (HP:0003470)2.07632543
97Cellulitis (HP:0100658)2.06685830
98Asplenia (HP:0001746)2.06549132
99Bronchiectasis (HP:0002110)2.06033965
100Sparse scalp hair (HP:0002209)2.05538633
101T lymphocytopenia (HP:0005403)2.04699787
102Orchitis (HP:0100796)2.04041189
103Thin bony cortex (HP:0002753)2.03486115
104Abnormal hair laboratory examination (HP:0003328)2.02845449
105Testicular atrophy (HP:0000029)2.02290326
106Abnormal respiratory motile cilium morphology (HP:0005938)2.01911031
107Abnormal respiratory epithelium morphology (HP:0012253)2.01911031
108IgG deficiency (HP:0004315)2.01252649
109Optic neuritis (HP:0100653)2.01227057
110Retrobulbar optic neuritis (HP:0100654)2.01227057
111Ulnar claw (HP:0001178)2.01132777
112Vasculitis (HP:0002633)2.01079986
113Hematochezia (HP:0002573)1.99380285
114Amyloidosis (HP:0011034)1.98859379
115Hypoparathyroidism (HP:0000829)1.98816635
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.97531245
117Hypergammaglobulinemia (HP:0010702)1.97443388
118Recurrent fungal infections (HP:0002841)1.95917867
119Chronic diarrhea (HP:0002028)1.95293951
120Recurrent bacterial skin infections (HP:0005406)1.95006790
121Sepsis (HP:0100806)1.94853235
122Hemoptysis (HP:0002105)1.93914315
123Skin ulcer (HP:0200042)1.93744665
124Prolonged bleeding time (HP:0003010)1.93534520
125Prostate neoplasm (HP:0100787)1.93319664
126Unilateral renal agenesis (HP:0000122)1.93205870
127Dry skin (HP:0000958)1.92196490
128Hypoalbuminemia (HP:0003073)1.92150107
129Abnormal albumin level (HP:0012116)1.92150107
130Abnormal respiratory motile cilium physiology (HP:0012261)1.91548190
131Hypochromic anemia (HP:0001931)1.90889082
132Anorexia (HP:0002039)1.90070797
133Xerostomia (HP:0000217)1.88981125
134Abnormality of the costochondral junction (HP:0000919)1.87251511
135Encephalitis (HP:0002383)1.86416771
136Abnormality of the fingertips (HP:0001211)1.86110373
137Chest pain (HP:0100749)1.83715680
138Episodic fever (HP:0001954)1.81158104
139Hemorrhage of the eye (HP:0011885)1.78012963
140Epistaxis (HP:0000421)1.76525936
141Papilloma (HP:0012740)1.75760189
142Verrucae (HP:0200043)1.75760189
143Hypermelanotic macule (HP:0001034)1.74932616
144Malnutrition (HP:0004395)1.73952252
145Peritonitis (HP:0002586)1.73410625
146Loss of speech (HP:0002371)1.71391018
147Increased cerebral lipofuscin (HP:0011813)1.71294504
148Pulmonary infiltrates (HP:0002113)1.71038061
149Cheilitis (HP:0100825)1.70093134
150Arterial thrombosis (HP:0004420)1.69528136
151Annular pancreas (HP:0001734)1.65006312
152Difficulty running (HP:0009046)1.64680856
153Melanocytic nevus (HP:0000995)1.63794521
154Hepatosplenomegaly (HP:0001433)1.63719572
155Inflammation of the large intestine (HP:0002037)1.63349800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.29909102
2MST44.15598415
3MAP4K13.90224715
4TESK23.43778294
5LIMK13.33057083
6PRPF4B3.08223330
7ERN13.03738165
8IRAK42.99271922
9KDR2.96938791
10TRPM72.93523150
11MAP3K122.91469745
12TXK2.69851976
13MAPKAPK32.67429949
14TNK22.60820292
15ZAP702.48484191
16TAOK12.17324932
17ITK2.15515677
18EPHB21.89302089
19RIPK41.88349397
20IRAK21.87051356
21STK101.81525040
22FER1.77644317
23LCK1.66748391
24MAP3K31.66030894
25TRIB31.60375813
26MARK21.59873292
27BLK1.59749210
28MAP2K61.53126428
29MAP3K111.48099628
30SIK31.47154718
31TAOK21.41601888
32LRRK21.37808139
33PRKD21.35107397
34IRAK11.32201985
35FES1.32058303
36MAP3K141.28722477
37PIM21.27940163
38FGFR11.26916726
39EIF2AK11.25845922
40JAK11.24272055
41MAP3K21.21137558
42IRAK31.18842581
43RPS6KB21.17809157
44IKBKE1.17450298
45RIPK11.17376991
46KSR21.14265743
47ERBB31.13552462
48SIK11.13451282
49SIK21.08691303
50PDGFRB1.06393422
51EIF2AK31.06237051
52FGFR41.04878834
53MAP3K131.04309349
54TEC1.03484800
55CSK1.00653052
56FGR0.99930035
57SMG10.99219484
58SYK0.98839805
59STK240.95755339
60MAP3K70.93350480
61MAPK150.91278653
62JAK30.91270202
63MARK30.88691747
64MST1R0.87865190
65PRKCQ0.87785271
66PIK3CG0.87410036
67MAP3K60.86355732
68MAP2K40.85007210
69ICK0.84508175
70MAPK70.84279381
71TYK20.83930340
72IKBKB0.82514177
73HCK0.82400378
74PDPK10.78673068
75CDK120.76777246
76CDC42BPA0.76603904
77MATK0.75071841
78PDK20.73807386
79BTK0.72808749
80MYLK0.72032607
81KIT0.68797551
82SGK30.66626427
83TTN0.64413518
84EPHB10.64342776
85HIPK20.64164213
86ROCK20.64056945
87FYN0.62837567
88DYRK30.62386977
89GRK70.62077459
90GRK60.61422378
91RPS6KC10.61410328
92RPS6KL10.61410328
93LYN0.59916011
94MAPKAPK50.59770756
95EEF2K0.57419549
96EIF2AK20.55312229
97SCYL20.55228444
98DYRK1B0.54657928
99CLK10.53951182
100ABL10.53917947
101BMX0.53692518
102PTK20.53605175
103EPHA30.53395936
104MAP3K10.53075761
105PTK60.52945860
106TGFBR10.52662747
107PDK10.51710481
108TBK10.51399944
109SGK2230.51144526
110SGK4940.51144526
111RPS6KA20.50792637
112RPS6KA60.50128796
113MAPK120.49323255
114MAP3K50.48769822
115WNK10.48138491
116TAOK30.47816798
117ROCK10.47262141
118GRK10.46481699
119STK110.46440186
120SRC0.46436474
121MOS0.44811415
122MAP2K30.44288634
123PRKD10.44266354
124AURKA0.43765674
125MAPK110.41844251
126FGFR20.41660049
127INSR0.41457754
128STK40.41411486
129YES10.41101140
130RPS6KA10.39876231
131NTRK20.39663953
132SGK20.38640747
133CAMK40.38475841
134RAF10.38394100
135JAK20.37768018
136STK390.35782117
137TLK10.33520639
138TGFBR20.33295482
139RPS6KA40.32396177
140MAPKAPK20.32262224
141ILK0.31699989
142BCR0.31303200
143EPHA20.29889235
144CDK90.29162310
145ERBB40.27827368
146PRKCD0.27554635
147TNIK0.26572202
148FGFR30.25934946
149DAPK30.25759023
150PRKCH0.24689960
151CHUK0.24678023

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.52361765
2Ribosome_Homo sapiens_hsa030103.95066997
3Sphingolipid metabolism_Homo sapiens_hsa006003.34939097
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.23555344
5Hematopoietic cell lineage_Homo sapiens_hsa046403.01995330
6T cell receptor signaling pathway_Homo sapiens_hsa046602.86538459
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.32261063
8Graft-versus-host disease_Homo sapiens_hsa053322.19936695
9Allograft rejection_Homo sapiens_hsa053302.05303616
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98489443
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.95508501
12Acute myeloid leukemia_Homo sapiens_hsa052211.94168351
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.80565015
14Leishmaniasis_Homo sapiens_hsa051401.76311838
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.70232779
16Viral myocarditis_Homo sapiens_hsa054161.64431500
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.64265333
18Staphylococcus aureus infection_Homo sapiens_hsa051501.63036305
19Malaria_Homo sapiens_hsa051441.61786990
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.60612864
21Other glycan degradation_Homo sapiens_hsa005111.57118353
22Arachidonic acid metabolism_Homo sapiens_hsa005901.55458558
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51291377
24Linoleic acid metabolism_Homo sapiens_hsa005911.50891312
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46590111
26Fatty acid elongation_Homo sapiens_hsa000621.45820716
27Measles_Homo sapiens_hsa051621.45512131
28GnRH signaling pathway_Homo sapiens_hsa049121.45374085
29Autoimmune thyroid disease_Homo sapiens_hsa053201.44499183
30Ether lipid metabolism_Homo sapiens_hsa005651.44318275
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39283955
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.38494776
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.38414979
34Influenza A_Homo sapiens_hsa051641.36042901
35Lysosome_Homo sapiens_hsa041421.29209925
36Pertussis_Homo sapiens_hsa051331.27522742
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.21776117
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19050775
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18879111
40VEGF signaling pathway_Homo sapiens_hsa043701.17646036
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17049040
42Sphingolipid signaling pathway_Homo sapiens_hsa040711.17017144
43Shigellosis_Homo sapiens_hsa051311.16162811
44p53 signaling pathway_Homo sapiens_hsa041151.14086219
45Non-small cell lung cancer_Homo sapiens_hsa052231.12819236
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11883600
47Salmonella infection_Homo sapiens_hsa051321.11281546
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10374242
49Osteoclast differentiation_Homo sapiens_hsa043801.09395950
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07804533
51Hepatitis B_Homo sapiens_hsa051611.05676987
52Chronic myeloid leukemia_Homo sapiens_hsa052201.02912752
53Dorso-ventral axis formation_Homo sapiens_hsa043200.99475806
54Toxoplasmosis_Homo sapiens_hsa051450.99059196
55Pancreatic cancer_Homo sapiens_hsa052120.98656260
56Basal cell carcinoma_Homo sapiens_hsa052170.97435797
57B cell receptor signaling pathway_Homo sapiens_hsa046620.97014577
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96861802
59Phagosome_Homo sapiens_hsa041450.96691901
60Renal cell carcinoma_Homo sapiens_hsa052110.93432460
61Antigen processing and presentation_Homo sapiens_hsa046120.92312945
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92189878
63Bladder cancer_Homo sapiens_hsa052190.91503574
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.88427247
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.86247416
66Apoptosis_Homo sapiens_hsa042100.86152349
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85593934
68Notch signaling pathway_Homo sapiens_hsa043300.84102663
69Asthma_Homo sapiens_hsa053100.83556298
70Choline metabolism in cancer_Homo sapiens_hsa052310.82928897
71Prolactin signaling pathway_Homo sapiens_hsa049170.81733444
72African trypanosomiasis_Homo sapiens_hsa051430.81066712
73Legionellosis_Homo sapiens_hsa051340.80782028
74ECM-receptor interaction_Homo sapiens_hsa045120.80013597
75Inositol phosphate metabolism_Homo sapiens_hsa005620.79845139
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78881581
77Adherens junction_Homo sapiens_hsa045200.77480745
78Histidine metabolism_Homo sapiens_hsa003400.76086473
79FoxO signaling pathway_Homo sapiens_hsa040680.74012028
80Rheumatoid arthritis_Homo sapiens_hsa053230.73150365
81Tuberculosis_Homo sapiens_hsa051520.72066966
82MAPK signaling pathway_Homo sapiens_hsa040100.71794768
83HTLV-I infection_Homo sapiens_hsa051660.69808964
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68994257
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68701320
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68147674
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67327293
88mTOR signaling pathway_Homo sapiens_hsa041500.66933882
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66688280
90Glioma_Homo sapiens_hsa052140.66293997
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65613298
92Endometrial cancer_Homo sapiens_hsa052130.64129499
93Insulin signaling pathway_Homo sapiens_hsa049100.63932535
94Rap1 signaling pathway_Homo sapiens_hsa040150.63597927
95Axon guidance_Homo sapiens_hsa043600.63550921
96Ovarian steroidogenesis_Homo sapiens_hsa049130.62900396
97Chemical carcinogenesis_Homo sapiens_hsa052040.62296903
98Platelet activation_Homo sapiens_hsa046110.60623520
99Long-term potentiation_Homo sapiens_hsa047200.58906014
100Insulin resistance_Homo sapiens_hsa049310.57819560
101Estrogen signaling pathway_Homo sapiens_hsa049150.57386303
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.55350163
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54857333
104Ras signaling pathway_Homo sapiens_hsa040140.53124909
105Systemic lupus erythematosus_Homo sapiens_hsa053220.52859350
106Proteoglycans in cancer_Homo sapiens_hsa052050.52757817
107Type I diabetes mellitus_Homo sapiens_hsa049400.51930833
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51902862
109ErbB signaling pathway_Homo sapiens_hsa040120.51173841
110TNF signaling pathway_Homo sapiens_hsa046680.50254868
111Chemokine signaling pathway_Homo sapiens_hsa040620.50158867
112Alzheimers disease_Homo sapiens_hsa050100.49365171
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49089300
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48959948
115Endocytosis_Homo sapiens_hsa041440.48609983
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48537382
117Herpes simplex infection_Homo sapiens_hsa051680.47202382
118Long-term depression_Homo sapiens_hsa047300.47151715
119Epstein-Barr virus infection_Homo sapiens_hsa051690.46050142
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45972983
121Pancreatic secretion_Homo sapiens_hsa049720.45889359
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43124126
123Retinol metabolism_Homo sapiens_hsa008300.40857796
124Renin secretion_Homo sapiens_hsa049240.38377312
125Fatty acid biosynthesis_Homo sapiens_hsa000610.37255924
126Amoebiasis_Homo sapiens_hsa051460.36146622
127MicroRNAs in cancer_Homo sapiens_hsa052060.35619608
128Oxidative phosphorylation_Homo sapiens_hsa001900.35451327
129ABC transporters_Homo sapiens_hsa020100.32138168
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31814246
131Hepatitis C_Homo sapiens_hsa051600.31716609
132Mineral absorption_Homo sapiens_hsa049780.31000596
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30947243
134Phenylalanine metabolism_Homo sapiens_hsa003600.30081175
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30049110
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29819307
137Tight junction_Homo sapiens_hsa045300.29564157
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.29480035
139Circadian rhythm_Homo sapiens_hsa047100.29347976
140Collecting duct acid secretion_Homo sapiens_hsa049660.28407418
141Protein export_Homo sapiens_hsa030600.28311008

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