KCNK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)7.04872577
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.86652429
3synaptic vesicle maturation (GO:0016188)6.73289650
4locomotory exploration behavior (GO:0035641)6.04766574
5synaptic vesicle exocytosis (GO:0016079)5.89870322
6glutamate secretion (GO:0014047)5.46022031
7vocalization behavior (GO:0071625)5.43075855
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35204841
9regulation of synaptic vesicle exocytosis (GO:2000300)5.02072502
10regulation of female gonad development (GO:2000194)4.96717628
11exploration behavior (GO:0035640)4.91018794
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.89603003
13layer formation in cerebral cortex (GO:0021819)4.82949791
14L-amino acid import (GO:0043092)4.82407552
15neurotransmitter secretion (GO:0007269)4.82327966
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.78326842
17regulation of acrosome reaction (GO:0060046)4.76949593
18regulation of glutamate receptor signaling pathway (GO:1900449)4.66488275
19gamma-aminobutyric acid transport (GO:0015812)4.62619090
20retinal cone cell development (GO:0046549)4.60533226
21proline transport (GO:0015824)4.57530434
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52974287
23neuron cell-cell adhesion (GO:0007158)4.52728263
24regulation of neuronal synaptic plasticity (GO:0048168)4.47500056
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.45874208
26protein localization to synapse (GO:0035418)4.39565812
27regulation of synaptic vesicle transport (GO:1902803)4.35584705
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.26169763
29neuromuscular process controlling posture (GO:0050884)4.23462002
30cellular potassium ion homeostasis (GO:0030007)4.22809116
31dendritic spine morphogenesis (GO:0060997)4.14043068
32sodium ion export (GO:0071436)4.12636648
33glutamate receptor signaling pathway (GO:0007215)4.10286604
34neuronal action potential propagation (GO:0019227)4.07458254
35amino acid import (GO:0043090)4.02507251
36synaptic transmission, glutamatergic (GO:0035249)3.98529801
37cerebellar Purkinje cell differentiation (GO:0021702)3.96980204
38regulation of synapse structural plasticity (GO:0051823)3.94291263
39neurotransmitter transport (GO:0006836)3.90265505
40neurotransmitter-gated ion channel clustering (GO:0072578)3.87297383
41regulation of DNA methylation (GO:0044030)3.82978060
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.82420466
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80569216
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78609729
45regulation of calcium ion-dependent exocytosis (GO:0017158)3.75138853
46positive regulation of synapse maturation (GO:0090129)3.74256437
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.71924220
48cell communication by electrical coupling (GO:0010644)3.70585085
49neuron recognition (GO:0008038)3.69108875
50neuron-neuron synaptic transmission (GO:0007270)3.69059979
51regulation of neurotransmitter levels (GO:0001505)3.65938150
52long-term memory (GO:0007616)3.64645167
53alanine transport (GO:0032328)3.64489661
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.62278226
55positive regulation of dendritic spine development (GO:0060999)3.62163152
56activation of protein kinase A activity (GO:0034199)3.56708646
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55527281
58potassium ion homeostasis (GO:0055075)3.54904473
59dendrite morphogenesis (GO:0048813)3.53685540
60glycine transport (GO:0015816)3.52965649
61positive regulation of membrane potential (GO:0045838)3.49099083
62neuromuscular process controlling balance (GO:0050885)3.48964811
63clathrin coat assembly (GO:0048268)3.48344014
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47792999
65protein kinase C signaling (GO:0070528)3.45543756
66postsynaptic membrane organization (GO:0001941)3.42647962
67transmission of nerve impulse (GO:0019226)3.42542727
68cell-cell junction maintenance (GO:0045217)3.41079979
69regulation of postsynaptic membrane potential (GO:0060078)3.38200424
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37836010
71synaptic vesicle endocytosis (GO:0048488)3.37628972
72regulation of synaptic plasticity (GO:0048167)3.32989393
73axonal fasciculation (GO:0007413)3.32665802
74cerebellar Purkinje cell layer development (GO:0021680)3.31693555
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.29622522
76regulation of vesicle fusion (GO:0031338)3.27346066
77phosphorelay signal transduction system (GO:0000160)3.25310949
78regulation of neurotransmitter secretion (GO:0046928)3.25128030
79neuronal ion channel clustering (GO:0045161)3.24684125
80positive regulation of meiosis (GO:0045836)3.21084288
81establishment of mitochondrion localization (GO:0051654)3.20019704
82regulation of ARF protein signal transduction (GO:0032012)3.18605425
83serotonin metabolic process (GO:0042428)3.17522327
84gamma-aminobutyric acid signaling pathway (GO:0007214)3.16715666
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15984170
86cerebellar granule cell differentiation (GO:0021707)3.15381331
87positive regulation of exocytosis (GO:0045921)3.14828732
88multicellular organism reproduction (GO:0032504)3.14319814
89synapse assembly (GO:0007416)3.14309521
90auditory behavior (GO:0031223)3.14107323
91potassium ion import (GO:0010107)3.13743865
92regulation of dendritic spine morphogenesis (GO:0061001)3.13332657
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12603827
94cell migration in hindbrain (GO:0021535)3.11927113
95mechanosensory behavior (GO:0007638)3.11711046
96membrane depolarization during action potential (GO:0086010)3.10907469
97regulation of exocytosis (GO:0017157)3.07421003
98membrane hyperpolarization (GO:0060081)3.05206209
99positive regulation of neurotransmitter secretion (GO:0001956)3.04616164
100response to pheromone (GO:0019236)3.03509762
101neuromuscular synaptic transmission (GO:0007274)3.03422808
102social behavior (GO:0035176)3.03210233
103intraspecies interaction between organisms (GO:0051703)3.03210233
104adult walking behavior (GO:0007628)3.00552191
105establishment of nucleus localization (GO:0040023)3.00463485
106response to auditory stimulus (GO:0010996)3.00453249
107calcium ion-dependent exocytosis (GO:0017156)2.98930956
108neuromuscular process (GO:0050905)2.97494049
109* synaptic transmission (GO:0007268)2.97446261
110neurofilament cytoskeleton organization (GO:0060052)2.97042585
111positive regulation of meiotic cell cycle (GO:0051446)2.96706202
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95509786
113organelle transport along microtubule (GO:0072384)2.95454103
114regulation of synapse maturation (GO:0090128)2.94727574
115dendritic spine organization (GO:0097061)2.93394765
116regulation of neurotransmitter transport (GO:0051588)2.93088045
117regulation of respiratory system process (GO:0044065)2.93025677
118cell differentiation in hindbrain (GO:0021533)2.92853421
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92840774
120vesicle transport along microtubule (GO:0047496)2.92328242
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.91830044
122synapse organization (GO:0050808)2.90091401
123long-term synaptic potentiation (GO:0060291)2.89890330
124cellular sodium ion homeostasis (GO:0006883)2.89471260
125regulation of dendritic spine development (GO:0060998)2.89416484
126regulation of synaptic transmission (GO:0050804)2.88555666
127membrane depolarization (GO:0051899)2.87932049
128presynaptic membrane organization (GO:0097090)2.84075025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05927525
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11545900
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11148898
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09990704
5* GBX2_23144817_ChIP-Seq_PC3_Human2.95567024
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.82238517
7* DROSHA_22980978_ChIP-Seq_HELA_Human2.79512236
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76175432
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76175432
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62950353
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61475196
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58880581
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.53680309
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52032508
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50407866
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44869791
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.42748536
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38484611
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.34165315
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.32141445
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.25380105
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16833644
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.16645319
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13072995
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11892474
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05252638
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01796993
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95488369
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.87445092
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85125351
31AR_21572438_ChIP-Seq_LNCaP_Human1.78509622
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.73518041
33ZNF274_21170338_ChIP-Seq_K562_Hela1.64966045
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61071976
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60708404
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57639509
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57334272
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51292715
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51167169
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.50715634
41* RING1B_27294783_Chip-Seq_ESCs_Mouse1.43480843
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36741017
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34635686
44* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28695038
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28108398
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27650543
47* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27532226
48KDM2B_26808549_Chip-Seq_K562_Human1.24611637
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22190040
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.20462330
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20016118
52* AR_19668381_ChIP-Seq_PC3_Human1.19831340
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17215828
54P300_19829295_ChIP-Seq_ESCs_Human1.16818908
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16157676
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15418265
57* AR_25329375_ChIP-Seq_VCAP_Human1.12965468
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12763778
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12288082
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11210130
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11082087
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11053067
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.10309312
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08505028
65* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08331283
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.07905187
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06599798
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05311113
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04487759
70* STAT3_23295773_ChIP-Seq_U87_Human1.03875078
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02314420
72* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02020158
73* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01850014
74* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01258837
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00942694
76OCT4_19829295_ChIP-Seq_ESCs_Human1.00449861
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99517247
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99278968
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98819966
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98709661
81TET1_21490601_ChIP-Seq_MESCs_Mouse0.98405710
82* KLF4_19829295_ChIP-Seq_ESCs_Human0.97411157
83TCF4_23295773_ChIP-Seq_U87_Human0.96585863
84* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96144898
85RXR_22108803_ChIP-Seq_LS180_Human0.96066775
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96008777
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95829362
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95055546
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93066389
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92505350
91* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92482446
92TAF15_26573619_Chip-Seq_HEK293_Human0.92028787
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.89591777
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88499141
95AHR_22903824_ChIP-Seq_MCF-7_Human0.87472135
96CTCF_27219007_Chip-Seq_Bcells_Human0.87205697
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87095464
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86125920
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86125920
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85960897
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.85742405
102* ARNT_22903824_ChIP-Seq_MCF-7_Human0.85575291
103RUNX2_22187159_ChIP-Seq_PCA_Human0.84525306
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83879313
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83728884
106EP300_21415370_ChIP-Seq_HL-1_Mouse0.82076275
107RNF2_27304074_Chip-Seq_NSC_Mouse0.81907794
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80275631
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80156076
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78484998
111* TP53_20018659_ChIP-ChIP_R1E_Mouse0.78419611
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78125146
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77752460
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77668327
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77537947
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75261683
117* SMAD4_21741376_ChIP-Seq_EPCs_Human0.73865833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.62253177
2MP0003635_abnormal_synaptic_transmissio4.17697298
3MP0003880_abnormal_central_pattern3.82759351
4MP0004270_analgesia3.75478791
5MP0009046_muscle_twitch3.56481904
6MP0005423_abnormal_somatic_nervous3.38608233
7MP0009745_abnormal_behavioral_response3.32326621
8MP0002063_abnormal_learning/memory/cond3.24992703
9MP0002064_seizures3.19434479
10MP0001968_abnormal_touch/_nociception2.99375029
11MP0002572_abnormal_emotion/affect_behav2.77115266
12MP0001486_abnormal_startle_reflex2.74825684
13MP0002734_abnormal_mechanical_nocicepti2.65955545
14MP0001501_abnormal_sleep_pattern2.49984567
15* MP0002272_abnormal_nervous_system2.45110818
16MP0002735_abnormal_chemical_nociception2.31755685
17MP0008877_abnormal_DNA_methylation2.27835843
18MP0002736_abnormal_nociception_after2.26579933
19MP0003329_amyloid_beta_deposits2.24003218
20MP0008569_lethality_at_weaning2.18902114
21MP0009780_abnormal_chondrocyte_physiolo2.14666773
22MP0002733_abnormal_thermal_nociception2.12938917
23MP0006276_abnormal_autonomic_nervous2.05745915
24MP0001440_abnormal_grooming_behavior1.99308341
25MP0003718_maternal_effect1.96617256
26MP0003122_maternal_imprinting1.94497052
27MP0001970_abnormal_pain_threshold1.94100270
28MP0002067_abnormal_sensory_capabilities1.86734098
29MP0004924_abnormal_behavior1.85018053
30MP0005386_behavior/neurological_phenoty1.85018053
31MP0002184_abnormal_innervation1.82283220
32MP0002557_abnormal_social/conspecific_i1.81747052
33MP0004811_abnormal_neuron_physiology1.81085520
34MP0002909_abnormal_adrenal_gland1.78938521
35MP0005646_abnormal_pituitary_gland1.76609022
36MP0004858_abnormal_nervous_system1.71514224
37MP0003121_genomic_imprinting1.70735485
38MP0000778_abnormal_nervous_system1.69321380
39MP0005645_abnormal_hypothalamus_physiol1.67440461
40MP0004885_abnormal_endolymph1.66981681
41MP0003787_abnormal_imprinting1.60256028
42MP0000955_abnormal_spinal_cord1.58842304
43MP0003879_abnormal_hair_cell1.56694588
44MP0004142_abnormal_muscle_tone1.54792048
45MP0003690_abnormal_glial_cell1.53185223
46MP0003633_abnormal_nervous_system1.50462809
47MP0006292_abnormal_olfactory_placode1.46549441
48MP0002066_abnormal_motor_capabilities/c1.45016879
49MP0002882_abnormal_neuron_morphology1.43336450
50MP0003283_abnormal_digestive_organ1.43240503
51MP0002822_catalepsy1.36904141
52MP0000569_abnormal_digit_pigmentation1.33655328
53MP0008872_abnormal_physiological_respon1.30386485
54MP0001905_abnormal_dopamine_level1.29920934
55MP0003631_nervous_system_phenotype1.24835529
56MP0004145_abnormal_muscle_electrophysio1.20943059
57MP0000566_synostosis1.20469098
58MP0003890_abnormal_embryonic-extraembry1.15418937
59MP0001502_abnormal_circadian_rhythm1.14796843
60MP0002152_abnormal_brain_morphology1.13523456
61MP0002638_abnormal_pupillary_reflex1.11381607
62MP0001984_abnormal_olfaction1.09802205
63MP0000604_amyloidosis1.05993995
64MP0005535_abnormal_body_temperature1.04483675
65MP0003634_abnormal_glial_cell1.04087538
66MP0002229_neurodegeneration1.00552828
67MP0000751_myopathy0.97023234
68MP0003632_abnormal_nervous_system0.96944611
69MP0000920_abnormal_myelination0.95119081
70MP0008789_abnormal_olfactory_epithelium0.92682820
71MP0005409_darkened_coat_color0.90096636
72MP0000631_abnormal_neuroendocrine_gland0.89101168
73MP0003123_paternal_imprinting0.89040245
74MP0001177_atelectasis0.88445887
75MP0004085_abnormal_heartbeat0.86361397
76MP0008874_decreased_physiological_sensi0.85684233
77MP0001986_abnormal_taste_sensitivity0.81144185
78MP0002234_abnormal_pharynx_morphology0.80285882
79MP0002069_abnormal_eating/drinking_beha0.80264317
80MP0003699_abnormal_female_reproductive0.79441374
81MP0002161_abnormal_fertility/fecundity0.79371410
82MP0004233_abnormal_muscle_weight0.78428271
83MP0002089_abnormal_postnatal_growth/wei0.76709339
84MP0003075_altered_response_to0.76620088
85MP0005187_abnormal_penis_morphology0.74189659
86MP0001348_abnormal_lacrimal_gland0.72880647
87MP0001963_abnormal_hearing_physiology0.69470711
88MP0005551_abnormal_eye_electrophysiolog0.69456045
89MP0005410_abnormal_fertilization0.69121465
90MP0001929_abnormal_gametogenesis0.68168998
91MP0003172_abnormal_lysosome_physiology0.67792112
92MP0008961_abnormal_basal_metabolism0.67596708
93MP0004742_abnormal_vestibular_system0.67284246
94MP0001299_abnormal_eye_distance/0.65698721
95MP0005167_abnormal_blood-brain_barrier0.65554611
96MP0004147_increased_porphyrin_level0.65318930
97MP0005394_taste/olfaction_phenotype0.65254886
98MP0005499_abnormal_olfactory_system0.65254886
99MP0002752_abnormal_somatic_nervous0.63754764
100MP0000026_abnormal_inner_ear0.63704772
101MP0002160_abnormal_reproductive_system0.63633783
102MP0003119_abnormal_digestive_system0.63576774
103MP0003698_abnormal_male_reproductive0.63061671
104MP0003137_abnormal_impulse_conducting0.63050999
105MP0000462_abnormal_digestive_system0.60264808
106MP0001529_abnormal_vocalization0.60187570
107MP0001943_abnormal_respiration0.60060925
108MP0010769_abnormal_survival0.59532573
109MP0003861_abnormal_nervous_system0.57234929
110MP0004043_abnormal_pH_regulation0.56596260
111MP0001485_abnormal_pinna_reflex0.56299218
112MP0010770_preweaning_lethality0.56224975
113MP0002082_postnatal_lethality0.56224975
114MP0004215_abnormal_myocardial_fiber0.55201343
115MP0010768_mortality/aging0.54974130
116MP0005395_other_phenotype0.54721255
117MP0002210_abnormal_sex_determination0.53322296
118MP0004510_myositis0.52997845
119MP0001188_hyperpigmentation0.52923633
120MP0004130_abnormal_muscle_cell0.52285827

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.55127192
2Focal motor seizures (HP:0011153)6.40015348
3Focal seizures (HP:0007359)5.88157061
4Visual hallucinations (HP:0002367)5.84093529
5Progressive cerebellar ataxia (HP:0002073)4.90777473
6Action tremor (HP:0002345)4.64919167
7Supranuclear gaze palsy (HP:0000605)4.35088613
8Epileptic encephalopathy (HP:0200134)4.32635972
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.98991610
10Papilledema (HP:0001085)3.68013499
11Generalized tonic-clonic seizures (HP:0002069)3.64514716
12Mutism (HP:0002300)3.62229175
13Ankle clonus (HP:0011448)3.59046193
14Poor eye contact (HP:0000817)3.58075960
15Broad-based gait (HP:0002136)3.52123627
16Urinary bladder sphincter dysfunction (HP:0002839)3.50714129
17Febrile seizures (HP:0002373)3.50426845
18Absence seizures (HP:0002121)3.47733595
19Atonic seizures (HP:0010819)3.43274708
20Genetic anticipation (HP:0003743)3.41812701
21Depression (HP:0000716)3.36484191
22Postural instability (HP:0002172)3.35680806
23Anxiety (HP:0000739)3.33546253
24Diminished motivation (HP:0000745)3.32091844
25Dialeptic seizures (HP:0011146)3.24257732
26Diplopia (HP:0000651)3.24003142
27Abnormality of binocular vision (HP:0011514)3.24003142
28Abnormal social behavior (HP:0012433)3.21690939
29Impaired social interactions (HP:0000735)3.21690939
30Impaired vibration sensation in the lower limbs (HP:0002166)3.20308725
31Agitation (HP:0000713)3.17352352
32Hemiplegia (HP:0002301)3.14998554
33Dysmetria (HP:0001310)3.06143618
34Dysdiadochokinesis (HP:0002075)3.05480592
35Abnormality of the corticospinal tract (HP:0002492)3.04212175
36Hemiparesis (HP:0001269)3.02717982
37Gaze-evoked nystagmus (HP:0000640)3.01763769
38Cerebral hypomyelination (HP:0006808)3.00306553
39Spastic gait (HP:0002064)2.99914346
40Cerebral inclusion bodies (HP:0100314)2.98971199
41Annular pancreas (HP:0001734)2.97267487
42Truncal ataxia (HP:0002078)2.92475352
43Excessive salivation (HP:0003781)2.92022662
44Drooling (HP:0002307)2.92022662
45Abnormal eating behavior (HP:0100738)2.91661897
46Neurofibrillary tangles (HP:0002185)2.90606396
47Impaired smooth pursuit (HP:0007772)2.86314263
48Sleep apnea (HP:0010535)2.77888886
49Epileptiform EEG discharges (HP:0011182)2.75569080
50EEG with generalized epileptiform discharges (HP:0011198)2.74889403
51Scanning speech (HP:0002168)2.72243914
52Hypsarrhythmia (HP:0002521)2.70491326
53Urinary urgency (HP:0000012)2.67871185
54Stereotypic behavior (HP:0000733)2.64144903
55Abnormal gallbladder physiology (HP:0012438)2.60164733
56Cholecystitis (HP:0001082)2.60164733
57Pheochromocytoma (HP:0002666)2.59625099
58Intention tremor (HP:0002080)2.58669232
59Ventricular fibrillation (HP:0001663)2.58052631
60Hyperventilation (HP:0002883)2.56404105
61Torticollis (HP:0000473)2.55920849
62Peripheral hypomyelination (HP:0007182)2.53969406
63Amyotrophic lateral sclerosis (HP:0007354)2.51425133
64Impulsivity (HP:0100710)2.50419030
65Abnormality of the lower motor neuron (HP:0002366)2.45257446
66Bradykinesia (HP:0002067)2.44595737
67Abnormality of ocular smooth pursuit (HP:0000617)2.43573989
68Akinesia (HP:0002304)2.39563646
69Bundle branch block (HP:0011710)2.37134609
70Spinal canal stenosis (HP:0003416)2.36148961
71Anterior segment dysgenesis (HP:0007700)2.35078481
72Supernumerary spleens (HP:0009799)2.34543983
73Termporal pattern (HP:0011008)2.31981957
74Insidious onset (HP:0003587)2.31981957
75Hypercortisolism (HP:0001578)2.31571209
76Focal dystonia (HP:0004373)2.29999585
77Fetal akinesia sequence (HP:0001989)2.28421784
78Progressive inability to walk (HP:0002505)2.27485471
79Status epilepticus (HP:0002133)2.25336165
80Insomnia (HP:0100785)2.23826427
81Delusions (HP:0000746)2.23191638
82Polyphagia (HP:0002591)2.21396806
83Lower limb muscle weakness (HP:0007340)2.21362739
84Limb dystonia (HP:0002451)2.16227595
85Amblyopia (HP:0000646)2.16164811
86Clonus (HP:0002169)2.14540037
87Psychosis (HP:0000709)2.13787585
88Dysmetric saccades (HP:0000641)2.11390328
89Abnormality of the labia minora (HP:0012880)2.09528296
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08841731
91Degeneration of the lateral corticospinal tracts (HP:0002314)2.07715312
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07715312
93Craniofacial dystonia (HP:0012179)2.06859651
94Neuroendocrine neoplasm (HP:0100634)2.05602406
95Inappropriate behavior (HP:0000719)2.05298501
96CNS hypomyelination (HP:0003429)2.05178096
97Increased circulating renin level (HP:0000848)2.03538886
98Impaired vibratory sensation (HP:0002495)2.01221988
99Obstructive sleep apnea (HP:0002870)2.00926753
100Apathy (HP:0000741)2.00334415
101Megalencephaly (HP:0001355)1.97369637
102Absent speech (HP:0001344)1.97071501
103Abnormal EKG (HP:0003115)1.95467281
104Morphological abnormality of the pyramidal tract (HP:0002062)1.94751626
105Generalized myoclonic seizures (HP:0002123)1.94215775
106Tetraplegia (HP:0002445)1.93037439
107Rigidity (HP:0002063)1.92562241
108Failure to thrive in infancy (HP:0001531)1.91697755
109Inability to walk (HP:0002540)1.91144617
110Hypoventilation (HP:0002791)1.90658689
111Macroorchidism (HP:0000053)1.89778956
112Hyperthyroidism (HP:0000836)1.89380719
113Memory impairment (HP:0002354)1.89248799
114Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.88713149
115Abnormality of salivation (HP:0100755)1.88515295
116Pointed chin (HP:0000307)1.87745039
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86927521
118Prolonged QT interval (HP:0001657)1.86140547
119Neuronal loss in central nervous system (HP:0002529)1.85662965
120Narrow nasal bridge (HP:0000446)1.84311192
121Choreoathetosis (HP:0001266)1.83999308
122Aqueductal stenosis (HP:0002410)1.83946987
123Incomplete penetrance (HP:0003829)1.82043190
124Abnormality of saccadic eye movements (HP:0000570)1.81085957
125Spastic tetraparesis (HP:0001285)1.80294728
126Retinal dysplasia (HP:0007973)1.78957040
127Lower limb asymmetry (HP:0100559)1.78944560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.71227509
2MARK14.67184311
3MAP3K94.32616588
4MAP3K42.99369838
5PAK62.66159860
6MINK12.63447805
7EPHA42.45342866
8DAPK22.28822202
9NTRK22.25088908
10MAP2K72.23308736
11PHKG21.94169710
12PHKG11.94169710
13CAMKK11.83708630
14LMTK21.77064335
15NTRK11.76777017
16KSR21.76614771
17MAP2K41.74794789
18NEK61.71643481
19SIK21.66934119
20PLK21.65796966
21GRK51.60644690
22PRKD31.59481675
23CDK51.56815723
24CDK191.53616044
25MAPK131.52623814
26LATS21.51279575
27STK381.44773186
28UHMK11.41667956
29KSR11.33367324
30RIPK41.32367722
31TNIK1.31031984
32DAPK11.22307161
33BRAF1.16715403
34MAP3K21.14837376
35PNCK1.12065514
36PRKCG1.11137725
37MAP3K121.10450143
38ALK1.09741046
39PAK31.07822678
40CSNK1G21.05560827
41STK111.04148014
42PINK11.03706574
43TYRO31.03433905
44CASK1.03246752
45CAMKK21.00860664
46FES1.00692350
47CAMK2A1.00409092
48RET0.98238603
49PRKCH0.95035017
50ADRBK20.93241715
51CDK150.92657016
52CDK120.92025689
53CDK180.90846982
54TAOK10.90607295
55CAMK10.88212971
56CDK140.84153582
57CDC42BPA0.78346743
58CDK11A0.78334015
59SCYL20.76870671
60RIPK10.76870623
61MAP3K130.76181453
62AURKA0.75926258
63OXSR10.75758985
64MOS0.75164488
65MARK20.74540112
66PRPF4B0.73154873
67SGK4940.71249441
68SGK2230.71249441
69PKN10.69481490
70TAOK30.66413223
71DYRK1A0.64156986
72PDK10.62629960
73PRKCI0.61767238
74ADRBK10.61521321
75SGK10.60041605
76SGK30.59283074
77CAMK1G0.58964539
78SGK20.57184458
79WNK30.56939470
80PDPK10.56463186
81WNK10.55962804
82FYN0.55875659
83MAP2K10.55825419
84WNK40.53316807
85CCNB10.53312918
86RPS6KA30.53282043
87CSNK1D0.53267746
88CAMK2B0.53152981
89NEK10.52681961
90CSNK1G30.51132484
91ERBB30.49699428
92CSNK1E0.48440505
93PRKCZ0.47629856
94TRIM280.46102758
95CAMK2D0.44890306
96ARAF0.44883163
97BRSK10.43751616
98MAP3K70.42837429
99CDK90.42713581
100DYRK1B0.42012652
101MAPK120.41802046
102MAP2K60.41759992
103* PRKACA0.41298603
104CAMK2G0.40792484
105MAPK100.40681962
106PRKG10.39917650
107GSK3B0.38717060
108MAP3K10.38538141
109DYRK20.38359210
110PTK2B0.38199027
111ROCK20.37975537
112CAMK40.37649981
113RAF10.37285150
114CAMK1D0.37113498
115TNK20.36573444
116MAP3K50.34101709
117PRKCE0.34094933
118MAP3K60.33662695
119PRKCA0.33130858
120LIMK10.32120264
121STK390.29899951
122PRKACB0.29535892

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52405506
2Synaptic vesicle cycle_Homo sapiens_hsa047213.46555896
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.79216650
4GABAergic synapse_Homo sapiens_hsa047272.70704741
5Circadian entrainment_Homo sapiens_hsa047132.68431293
6Glutamatergic synapse_Homo sapiens_hsa047242.55205730
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52286539
8Long-term potentiation_Homo sapiens_hsa047202.50271408
9Olfactory transduction_Homo sapiens_hsa047402.39639895
10Salivary secretion_Homo sapiens_hsa049702.37419201
11Morphine addiction_Homo sapiens_hsa050322.35695784
12Insulin secretion_Homo sapiens_hsa049112.27683017
13Amphetamine addiction_Homo sapiens_hsa050312.19178544
14Dopaminergic synapse_Homo sapiens_hsa047282.10429169
15Gastric acid secretion_Homo sapiens_hsa049711.94783994
16Cholinergic synapse_Homo sapiens_hsa047251.87008554
17* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80199411
18Serotonergic synapse_Homo sapiens_hsa047261.79511318
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71810149
20Taste transduction_Homo sapiens_hsa047421.68989177
21Long-term depression_Homo sapiens_hsa047301.66769547
22Renin secretion_Homo sapiens_hsa049241.63722067
23Cocaine addiction_Homo sapiens_hsa050301.62644634
24Type II diabetes mellitus_Homo sapiens_hsa049301.57030950
25Calcium signaling pathway_Homo sapiens_hsa040201.55746825
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51625873
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50080784
28Nitrogen metabolism_Homo sapiens_hsa009101.49106173
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44600270
30GnRH signaling pathway_Homo sapiens_hsa049121.39273917
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34229602
32Gap junction_Homo sapiens_hsa045401.33700377
33Estrogen signaling pathway_Homo sapiens_hsa049151.24755632
34cAMP signaling pathway_Homo sapiens_hsa040241.20620620
35Axon guidance_Homo sapiens_hsa043601.19745605
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19487594
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07721157
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04639757
39Collecting duct acid secretion_Homo sapiens_hsa049661.03389412
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02714628
41Pancreatic secretion_Homo sapiens_hsa049721.00493538
42Thyroid hormone synthesis_Homo sapiens_hsa049180.99954703
43Melanogenesis_Homo sapiens_hsa049160.99181078
44ErbB signaling pathway_Homo sapiens_hsa040120.94668365
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94210508
46Glioma_Homo sapiens_hsa052140.93934030
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87395206
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.86633367
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85925901
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.85635032
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84456386
52Dorso-ventral axis formation_Homo sapiens_hsa043200.83478924
53Cardiac muscle contraction_Homo sapiens_hsa042600.78978468
54Oocyte meiosis_Homo sapiens_hsa041140.76331876
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75976554
56Bile secretion_Homo sapiens_hsa049760.74372113
57Vibrio cholerae infection_Homo sapiens_hsa051100.72605645
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72577222
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72522427
60Choline metabolism in cancer_Homo sapiens_hsa052310.72038291
61Dilated cardiomyopathy_Homo sapiens_hsa054140.71858585
62Fatty acid biosynthesis_Homo sapiens_hsa000610.68833823
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67282560
64MAPK signaling pathway_Homo sapiens_hsa040100.66855442
65Glucagon signaling pathway_Homo sapiens_hsa049220.63145827
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61336708
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.60654782
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58043114
69mTOR signaling pathway_Homo sapiens_hsa041500.54808589
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53306431
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.51761941
72Ras signaling pathway_Homo sapiens_hsa040140.50225038
73Type I diabetes mellitus_Homo sapiens_hsa049400.49901420
74Prion diseases_Homo sapiens_hsa050200.49213542
75Endocytosis_Homo sapiens_hsa041440.49109354
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49106145
77Vitamin B6 metabolism_Homo sapiens_hsa007500.46706181
78VEGF signaling pathway_Homo sapiens_hsa043700.46513543
79Rap1 signaling pathway_Homo sapiens_hsa040150.44880660
80Inositol phosphate metabolism_Homo sapiens_hsa005620.44878449
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43496988
82Insulin signaling pathway_Homo sapiens_hsa049100.43417168
83Arginine and proline metabolism_Homo sapiens_hsa003300.42933827
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42929031
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42103680
86Phototransduction_Homo sapiens_hsa047440.41954411
87Alcoholism_Homo sapiens_hsa050340.41807262
88Renal cell carcinoma_Homo sapiens_hsa052110.41051104
89Circadian rhythm_Homo sapiens_hsa047100.40684473
90Wnt signaling pathway_Homo sapiens_hsa043100.40588821
91Ovarian steroidogenesis_Homo sapiens_hsa049130.39569065
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39204506
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39040314
94Endometrial cancer_Homo sapiens_hsa052130.39007729
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38809142
96Butanoate metabolism_Homo sapiens_hsa006500.35960415
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35814116
98African trypanosomiasis_Homo sapiens_hsa051430.35544893
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33955431
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32883800
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32264336
102Platelet activation_Homo sapiens_hsa046110.31660663
103Alzheimers disease_Homo sapiens_hsa050100.28364922
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28156192
105Chemokine signaling pathway_Homo sapiens_hsa040620.27876130
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27064658
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25889427
108Colorectal cancer_Homo sapiens_hsa052100.25513303
109Arginine biosynthesis_Homo sapiens_hsa002200.25197347
110AMPK signaling pathway_Homo sapiens_hsa041520.23632266
111Hippo signaling pathway_Homo sapiens_hsa043900.21928257
112Basal transcription factors_Homo sapiens_hsa030220.19732512
113ABC transporters_Homo sapiens_hsa020100.19339507
114HIF-1 signaling pathway_Homo sapiens_hsa040660.18273003

Most similar genes based on co-expression Upload to Enrichr

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