KCNMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.35962427
2synaptic vesicle exocytosis (GO:0016079)5.29649478
3protein localization to synapse (GO:0035418)5.29227152
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18855178
5vocalization behavior (GO:0071625)5.04288932
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.00991542
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.91482547
8G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.90941279
9regulation of synaptic vesicle exocytosis (GO:2000300)4.81349900
10neuron cell-cell adhesion (GO:0007158)4.78967841
11positive regulation of synapse maturation (GO:0090129)4.74352119
12glutamate receptor signaling pathway (GO:0007215)4.70588020
13gamma-aminobutyric acid signaling pathway (GO:0007214)4.68911711
14glutamate secretion (GO:0014047)4.66670686
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.61224872
16neurotransmitter-gated ion channel clustering (GO:0072578)4.56742134
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.44665004
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.40791923
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.39017735
20regulation of glutamate receptor signaling pathway (GO:1900449)4.32838315
21regulation of synaptic vesicle transport (GO:1902803)4.31556990
22neuron-neuron synaptic transmission (GO:0007270)4.27606452
23synaptic transmission, glutamatergic (GO:0035249)4.22508297
24neuronal action potential propagation (GO:0019227)4.10438371
25synaptic vesicle maturation (GO:0016188)4.05316175
26locomotory exploration behavior (GO:0035641)4.04427277
27synaptic vesicle endocytosis (GO:0048488)3.98203808
28regulation of synapse maturation (GO:0090128)3.83121882
29presynaptic membrane assembly (GO:0097105)3.82871880
30long-term memory (GO:0007616)3.79735063
31positive regulation of dendritic spine morphogenesis (GO:0061003)3.74168745
32response to histamine (GO:0034776)3.73932692
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73238839
34regulation of postsynaptic membrane potential (GO:0060078)3.73202856
35long-term synaptic potentiation (GO:0060291)3.72350110
36regulation of synaptic transmission, glutamatergic (GO:0051966)3.72128679
37neurotransmitter secretion (GO:0007269)3.72051171
38layer formation in cerebral cortex (GO:0021819)3.60848004
39innervation (GO:0060384)3.55751312
40positive regulation of membrane potential (GO:0045838)3.53377707
41neuron recognition (GO:0008038)3.49959359
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49143008
43cerebellar Purkinje cell differentiation (GO:0021702)3.48747763
44exploration behavior (GO:0035640)3.47536282
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.44752088
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44079444
47presynaptic membrane organization (GO:0097090)3.43758260
48response to pheromone (GO:0019236)3.43141500
49postsynaptic membrane organization (GO:0001941)3.41903012
50membrane hyperpolarization (GO:0060081)3.41342996
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41099598
52regulation of vesicle fusion (GO:0031338)3.39933123
53regulation of neurotransmitter secretion (GO:0046928)3.39676733
54regulation of neuronal synaptic plasticity (GO:0048168)3.37335483
55long term synaptic depression (GO:0060292)3.33155380
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32085423
57behavioral fear response (GO:0001662)3.28218545
58behavioral defense response (GO:0002209)3.28218545
59neurotransmitter transport (GO:0006836)3.26251746
60synapse assembly (GO:0007416)3.26164236
61cerebellar granule cell differentiation (GO:0021707)3.24929848
62regulation of dendritic spine morphogenesis (GO:0061001)3.20818749
63fear response (GO:0042596)3.20084512
64transmission of nerve impulse (GO:0019226)3.19608346
65striatum development (GO:0021756)3.18794210
66detection of light stimulus involved in sensory perception (GO:0050962)3.17159845
67detection of light stimulus involved in visual perception (GO:0050908)3.17159845
68membrane depolarization during action potential (GO:0086010)3.16889377
69righting reflex (GO:0060013)3.16030496
70membrane depolarization (GO:0051899)3.15853770
71positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.15786723
72behavioral response to cocaine (GO:0048148)3.15700146
73regulation of synaptic plasticity (GO:0048167)3.15219075
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15063965
75mating behavior (GO:0007617)3.14546046
76startle response (GO:0001964)3.13232152
77detection of calcium ion (GO:0005513)3.12629737
78response to auditory stimulus (GO:0010996)3.11561774
79regulation of neurotransmitter transport (GO:0051588)3.11454726
80negative regulation of dendrite morphogenesis (GO:0050774)3.09295445
81regulation of synapse structural plasticity (GO:0051823)3.07797494
82regulation of voltage-gated calcium channel activity (GO:1901385)3.07694336
83axonal fasciculation (GO:0007413)3.06822960
84retinal rod cell development (GO:0046548)3.04362729
85* cellular potassium ion homeostasis (GO:0030007)3.04000953
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03785696
87positive regulation of neurotransmitter secretion (GO:0001956)3.03743699
88cytoskeletal anchoring at plasma membrane (GO:0007016)3.03537118
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00280875
90cell communication by electrical coupling (GO:0010644)2.98816453
91positive regulation of dendritic spine development (GO:0060999)2.98757583
92establishment of synaptic vesicle localization (GO:0097480)2.98095363
93synaptic vesicle transport (GO:0048489)2.98095363
94response to gravity (GO:0009629)2.97996216
95* synaptic transmission (GO:0007268)2.97959350
96learning (GO:0007612)2.97281614
97positive regulation of synaptic transmission (GO:0050806)2.94781234
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94289714
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93862041
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92723884
101dendritic spine morphogenesis (GO:0060997)2.91130025
102positive regulation of neurotransmitter transport (GO:0051590)2.90562810
103sodium ion export (GO:0071436)2.90086855
104cerebellar Purkinje cell layer development (GO:0021680)2.87473414
105regulation of neurotransmitter levels (GO:0001505)2.84569389
106gamma-aminobutyric acid transport (GO:0015812)2.84201117
107neuromuscular process controlling posture (GO:0050884)2.82522960
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81657096
109regulation of ARF protein signal transduction (GO:0032012)2.81583594
110neuromuscular process controlling balance (GO:0050885)2.66943475
111cellular sodium ion homeostasis (GO:0006883)2.66651514
112L-amino acid import (GO:0043092)2.64422191
113plasma membrane repair (GO:0001778)2.63556596
114potassium ion import (GO:0010107)2.59702832
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.58876502
116neuronal ion channel clustering (GO:0045161)2.57886456
117amino acid import (GO:0043090)2.56957931
118positive regulation of axon extension (GO:0045773)2.50596364
119regulation of cell communication by electrical coupling (GO:0010649)2.49250274
120regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.48264713
121G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43875435
122* potassium ion homeostasis (GO:0055075)2.41776564
123chemosensory behavior (GO:0007635)2.41246090
124axon extension (GO:0048675)2.41183496
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40885994
126positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.39039476
127regulation of dendritic spine development (GO:0060998)2.38289372
128cell differentiation in hindbrain (GO:0021533)2.37731843
129proline transport (GO:0015824)2.35879059
130protein localization to endosome (GO:0036010)2.34953641
131positive regulation of fibroblast migration (GO:0010763)2.34156659
132cell communication involved in cardiac conduction (GO:0086065)2.30008879
133kidney mesenchyme development (GO:0072074)2.29356657
134neuromuscular process (GO:0050905)2.27112687
135signal release (GO:0023061)2.26806883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.12456664
2* GBX2_23144817_ChIP-Seq_PC3_Human4.37343307
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96655264
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90053608
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88155178
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58991091
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.52790945
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46606500
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46412997
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40429472
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39949951
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39949951
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.36470728
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30362479
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27741156
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.25740815
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20150364
18* TAF15_26573619_Chip-Seq_HEK293_Human2.19418691
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18604594
20DROSHA_22980978_ChIP-Seq_HELA_Human2.16597812
21* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08157076
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07081527
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.06775930
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.05511772
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04705473
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04421671
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03639695
28AR_21572438_ChIP-Seq_LNCaP_Human1.99409803
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.98661714
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.96634786
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96029178
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94224893
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.93290821
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.89485813
35* P300_19829295_ChIP-Seq_ESCs_Human1.77540879
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76666497
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76232691
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73101031
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.68577578
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68150618
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67492826
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65717263
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64572714
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.62840246
45FUS_26573619_Chip-Seq_HEK293_Human1.57090170
46VDR_22108803_ChIP-Seq_LS180_Human1.53913076
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.51371743
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.50086277
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48059260
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47846108
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45732539
52* AR_25329375_ChIP-Seq_VCAP_Human1.44662162
53IGF1R_20145208_ChIP-Seq_DFB_Human1.43849392
54* STAT3_23295773_ChIP-Seq_U87_Human1.43663548
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42697548
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42131757
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40181020
58* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37987945
59ZNF274_21170338_ChIP-Seq_K562_Hela1.37873748
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36487210
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36376630
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35411284
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.34654936
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.34333402
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33357351
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30296279
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30147217
68CJUN_26792858_Chip-Seq_BT549_Human1.28651131
69RNF2_27304074_Chip-Seq_NSC_Mouse1.28223549
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28105553
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28105553
72* TCF4_23295773_ChIP-Seq_U87_Human1.28000765
73* ESR2_21235772_ChIP-Seq_MCF-7_Human1.25863652
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25589859
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25538358
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20891911
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20527237
78* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20037970
79* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20035909
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18801781
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18083768
82AR_19668381_ChIP-Seq_PC3_Human1.18054567
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18050260
84ER_23166858_ChIP-Seq_MCF-7_Human1.17562059
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.17550537
86* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17407633
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.16756032
88BCAT_22108803_ChIP-Seq_LS180_Human1.14170579
89RUNX2_22187159_ChIP-Seq_PCA_Human1.12536191
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.12208953
91KDM2B_26808549_Chip-Seq_K562_Human1.11473726
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08971237
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.08639113
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08564391
95* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07469552
96* TET1_21490601_ChIP-Seq_MESCs_Mouse1.07056344
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06576726
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06576726
99AHR_22903824_ChIP-Seq_MCF-7_Human1.06450957
100* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05851287
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05815804
102TP53_20018659_ChIP-ChIP_R1E_Mouse1.05784342
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05213356
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05068349
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04719574
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03875611
107JUN_21703547_ChIP-Seq_K562_Human1.03793647
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03403350
109* BRD4_25478319_ChIP-Seq_HGPS_Human1.03206249
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00595889
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99071472
112* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98751878
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98196549
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.98119833
115* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97750149
116* TP53_16413492_ChIP-PET_HCT116_Human0.96615573
117* KDM2B_26808549_Chip-Seq_REH_Human0.96554431
118* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96516276
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.95928541
120* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95241582
121* TP53_18474530_ChIP-ChIP_U2OS_Human0.94482480
122* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93158306
123* SMAD3_21741376_ChIP-Seq_ESCs_Human0.92604276
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92110362
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.87613062
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87520960
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87294717
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.86616483
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86194439
130* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82880141
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82294171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.22652077
2MP0004859_abnormal_synaptic_plasticity5.04484705
3* MP0003635_abnormal_synaptic_transmissio3.77843509
4MP0004270_analgesia3.24271841
5MP0009745_abnormal_behavioral_response3.20923934
6MP0008438_abnormal_cutaneous_collagen3.19307150
7MP0009046_muscle_twitch3.11088894
8MP0001968_abnormal_touch/_nociception3.06807117
9* MP0002063_abnormal_learning/memory/cond3.04006639
10MP0002064_seizures2.97876420
11MP0002572_abnormal_emotion/affect_behav2.72447657
12MP0002734_abnormal_mechanical_nocicepti2.59046180
13MP0001984_abnormal_olfaction2.57350194
14* MP0002272_abnormal_nervous_system2.57335473
15MP0005423_abnormal_somatic_nervous2.43802229
16MP0002736_abnormal_nociception_after2.42847848
17MP0001486_abnormal_startle_reflex2.41884839
18MP0001501_abnormal_sleep_pattern2.41237869
19MP0005623_abnormal_meninges_morphology2.40802627
20MP0005551_abnormal_eye_electrophysiolog2.39086526
21MP0002735_abnormal_chemical_nociception2.32733935
22* MP0002067_abnormal_sensory_capabilities2.17399548
23MP0001440_abnormal_grooming_behavior2.04411239
24MP0002909_abnormal_adrenal_gland1.91304415
25MP0001502_abnormal_circadian_rhythm1.86912114
26MP0001958_emphysema1.85666490
27MP0006276_abnormal_autonomic_nervous1.85070795
28MP0002822_catalepsy1.84387473
29* MP0002184_abnormal_innervation1.83521787
30MP0001188_hyperpigmentation1.81894905
31MP0009780_abnormal_chondrocyte_physiolo1.81019993
32MP0001970_abnormal_pain_threshold1.80602926
33MP0005646_abnormal_pituitary_gland1.78765999
34MP0003705_abnormal_hypodermis_morpholog1.73820270
35MP0002733_abnormal_thermal_nociception1.72070244
36MP0005386_behavior/neurological_phenoty1.68790718
37MP0004924_abnormal_behavior1.68790718
38MP0002557_abnormal_social/conspecific_i1.68686288
39MP0004145_abnormal_muscle_electrophysio1.67643492
40MP0008569_lethality_at_weaning1.67341584
41MP0006072_abnormal_retinal_apoptosis1.66612864
42MP0001529_abnormal_vocalization1.63670811
43MP0000778_abnormal_nervous_system1.58131457
44MP0005645_abnormal_hypothalamus_physiol1.51677021
45MP0003329_amyloid_beta_deposits1.49453634
46MP0003279_aneurysm1.49190560
47MP0003787_abnormal_imprinting1.40826558
48* MP0002882_abnormal_neuron_morphology1.39076849
49MP0000920_abnormal_myelination1.38335035
50MP0002090_abnormal_vision1.37021189
51MP0005503_abnormal_tendon_morphology1.34933372
52MP0004811_abnormal_neuron_physiology1.34350481
53MP0002638_abnormal_pupillary_reflex1.32957095
54MP0000955_abnormal_spinal_cord1.32912348
55MP0000003_abnormal_adipose_tissue1.32279087
56MP0005275_abnormal_skin_tensile1.31607771
57MP0003122_maternal_imprinting1.30540022
58MP0003950_abnormal_plasma_membrane1.30333058
59* MP0002066_abnormal_motor_capabilities/c1.28616433
60MP0002837_dystrophic_cardiac_calcinosis1.27532437
61MP0001905_abnormal_dopamine_level1.25669132
62MP0004742_abnormal_vestibular_system1.25394234
63MP0003045_fibrosis1.23191509
64MP0005253_abnormal_eye_physiology1.22928793
65MP0000749_muscle_degeneration1.21371668
66MP0004142_abnormal_muscle_tone1.19382857
67MP0004510_myositis1.19158785
68* MP0003879_abnormal_hair_cell1.17625737
69MP0003690_abnormal_glial_cell1.17425464
70* MP0002229_neurodegeneration1.15962899
71MP0006292_abnormal_olfactory_placode1.15414398
72MP0000534_abnormal_ureter_morphology1.15359318
73MP0003633_abnormal_nervous_system1.14153104
74MP0004858_abnormal_nervous_system1.12362869
75MP0002876_abnormal_thyroid_physiology1.12164824
76MP0005394_taste/olfaction_phenotype1.12098698
77MP0005499_abnormal_olfactory_system1.12098698
78MP0002896_abnormal_bone_mineralization1.10804622
79MP0003123_paternal_imprinting1.10247070
80MP0000631_abnormal_neuroendocrine_gland1.08453915
81MP0003091_abnormal_cell_migration1.06875743
82MP0000013_abnormal_adipose_tissue1.06870530
83MP0005595_abnormal_vascular_smooth1.06471937
84MP0004885_abnormal_endolymph1.06212771
85MP0000751_myopathy1.03796832
86MP0001348_abnormal_lacrimal_gland1.03308668
87* MP0010386_abnormal_urinary_bladder1.01068448
88MP0003183_abnormal_peptide_metabolism1.00302944
89MP0002295_abnormal_pulmonary_circulatio0.99614610
90MP0004233_abnormal_muscle_weight0.97997602
91MP0003566_abnormal_cell_adhesion0.96888388
92* MP0002752_abnormal_somatic_nervous0.96669090
93MP0008872_abnormal_physiological_respon0.95789139
94MP0002152_abnormal_brain_morphology0.95773606
95MP0004272_abnormal_basement_membrane0.95731232
96MP0004043_abnormal_pH_regulation0.95200864
97MP0004215_abnormal_myocardial_fiber0.95080385
98MP0010368_abnormal_lymphatic_system0.93356269
99MP0003631_nervous_system_phenotype0.92383187
100* MP0001963_abnormal_hearing_physiology0.90805757
101MP0005257_abnormal_intraocular_pressure0.89375691
102MP0001542_abnormal_bone_strength0.88531118
103MP0004085_abnormal_heartbeat0.88152165
104MP0003075_altered_response_to0.87695015
105MP0003172_abnormal_lysosome_physiology0.87073106
106MP0002069_abnormal_eating/drinking_beha0.86987195
107MP0000759_abnormal_skeletal_muscle0.84620989
108MP0004130_abnormal_muscle_cell0.84451695
109MP0005535_abnormal_body_temperature0.82041699
110MP0000747_muscle_weakness0.81945978
111* MP0005620_abnormal_muscle_contractility0.81803974
112MP0009384_cardiac_valve_regurgitation0.80275038
113MP0000462_abnormal_digestive_system0.79122399
114MP0005195_abnormal_posterior_eye0.79055991
115MP0001664_abnormal_digestion0.78592438
116MP0001485_abnormal_pinna_reflex0.74757784
117MP0005409_darkened_coat_color0.73637823
118MP0001177_atelectasis0.72704426
119MP0002234_abnormal_pharynx_morphology0.72127836
120MP0000569_abnormal_digit_pigmentation0.71806941
121MP0000733_abnormal_muscle_development0.71359198
122* MP0004036_abnormal_muscle_relaxation0.69635240
123MP0004134_abnormal_chest_morphology0.69441933
124MP0008874_decreased_physiological_sensi0.68989386
125MP0005379_endocrine/exocrine_gland_phen0.68706179
126MP0004484_altered_response_of0.68105871
127MP0003283_abnormal_digestive_organ0.66682362
128MP0000767_abnormal_smooth_muscle0.66465733
129MP0000538_abnormal_urinary_bladder0.66223845
130MP0003634_abnormal_glial_cell0.65829292
131MP0008789_abnormal_olfactory_epithelium0.63354742
132MP0005171_absent_coat_pigmentation0.59486965
133* MP0000026_abnormal_inner_ear0.59429636
134MP0003632_abnormal_nervous_system0.55822834
135MP0003137_abnormal_impulse_conducting0.55662544
136MP0001943_abnormal_respiration0.55067455
137MP0001299_abnormal_eye_distance/0.51375139
138MP0001765_abnormal_ion_homeostasis0.51285379
139MP0000604_amyloidosis0.50752403

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78854994
2Epileptic encephalopathy (HP:0200134)6.00298522
3Febrile seizures (HP:0002373)5.44618454
4Atonic seizures (HP:0010819)5.40866272
5Focal seizures (HP:0007359)5.36870614
6Visual hallucinations (HP:0002367)4.55681403
7Congenital stationary night blindness (HP:0007642)4.54472153
8Myokymia (HP:0002411)4.52391824
9Progressive cerebellar ataxia (HP:0002073)4.48872919
10* Absence seizures (HP:0002121)4.21223752
11Hyperventilation (HP:0002883)4.11388824
12Protrusio acetabuli (HP:0003179)3.82900221
13* Dialeptic seizures (HP:0011146)3.79023037
14Broad-based gait (HP:0002136)3.68438234
15* Generalized tonic-clonic seizures (HP:0002069)3.53283717
16Gaze-evoked nystagmus (HP:0000640)3.52027032
17Aortic aneurysm (HP:0004942)3.47544200
18Premature rupture of membranes (HP:0001788)3.40686960
19Dysdiadochokinesis (HP:0002075)3.34568928
20Truncal ataxia (HP:0002078)3.27478636
21Type 1 muscle fiber predominance (HP:0003803)3.23597556
22Central scotoma (HP:0000603)3.14289264
23Aortic dissection (HP:0002647)3.09399598
24Drooling (HP:0002307)3.08274908
25Excessive salivation (HP:0003781)3.08274908
26Abnormality of macular pigmentation (HP:0008002)3.03742554
27Action tremor (HP:0002345)2.95733365
28Amblyopia (HP:0000646)2.95104532
29Poor eye contact (HP:0000817)2.91930262
30Obstructive sleep apnea (HP:0002870)2.91262694
31Broad metatarsal (HP:0001783)2.84550662
32* Epileptiform EEG discharges (HP:0011182)2.78977500
33Hemiparesis (HP:0001269)2.78043668
34Absent speech (HP:0001344)2.76508028
35Ankle contracture (HP:0006466)2.73303863
36Dysmetria (HP:0001310)2.72059042
37Depression (HP:0000716)2.72038314
38Supranuclear gaze palsy (HP:0000605)2.71747330
39Anxiety (HP:0000739)2.62967732
40Genetic anticipation (HP:0003743)2.62311066
41Scanning speech (HP:0002168)2.61402052
42Gait imbalance (HP:0002141)2.61043437
43Intention tremor (HP:0002080)2.55797716
44Abnormal social behavior (HP:0012433)2.55476350
45Impaired social interactions (HP:0000735)2.55476350
46Hypsarrhythmia (HP:0002521)2.55226419
47* EEG with generalized epileptiform discharges (HP:0011198)2.55226419
48Impaired smooth pursuit (HP:0007772)2.50394805
49Protruding tongue (HP:0010808)2.49843028
50Vascular tortuosity (HP:0004948)2.48385787
51Overgrowth (HP:0001548)2.43403854
52Spinal rigidity (HP:0003306)2.43088852
53Dysmetric saccades (HP:0000641)2.39119634
54Arterial tortuosity (HP:0005116)2.38315388
55Shallow orbits (HP:0000586)2.38135875
56Medial flaring of the eyebrow (HP:0010747)2.38071175
57Widely spaced teeth (HP:0000687)2.34283848
58Inability to walk (HP:0002540)2.34251282
59Congenital primary aphakia (HP:0007707)2.32876819
60Cerebral inclusion bodies (HP:0100314)2.31175950
61Abnormal eating behavior (HP:0100738)2.30932674
62Papilledema (HP:0001085)2.29094619
63Urinary bladder sphincter dysfunction (HP:0002839)2.28950650
64Slender build (HP:0001533)2.28508947
65Nephrogenic diabetes insipidus (HP:0009806)2.23430746
66Wormian bones (HP:0002645)2.22045989
67Postural tremor (HP:0002174)2.21687740
68Decreased circulating renin level (HP:0003351)2.20241894
69Polyphagia (HP:0002591)2.18863486
70Postural instability (HP:0002172)2.18708191
71Decreased central vision (HP:0007663)2.18435688
72Neurofibrillary tangles (HP:0002185)2.17664334
73Focal dystonia (HP:0004373)2.17593587
74Impaired vibration sensation in the lower limbs (HP:0002166)2.17351668
75Nuclear cataract (HP:0100018)2.14245095
76Fetal akinesia sequence (HP:0001989)2.13185597
77Follicular hyperkeratosis (HP:0007502)2.13163149
78Abnormality of binocular vision (HP:0011514)2.13145119
79Diplopia (HP:0000651)2.13145119
80Mitral stenosis (HP:0001718)2.12445042
81Abnormality of ocular smooth pursuit (HP:0000617)2.11806517
82Lower limb amyotrophy (HP:0007210)2.11525251
83Increased variability in muscle fiber diameter (HP:0003557)2.10634209
84Abnormality of salivation (HP:0100755)2.08785857
85Status epilepticus (HP:0002133)2.08383734
86Stereotypic behavior (HP:0000733)2.06542297
87Mutism (HP:0002300)2.06258114
88Bradykinesia (HP:0002067)2.06112177
89Blue irides (HP:0000635)2.05838413
90Vertebral compression fractures (HP:0002953)2.03615946
91Cervical subluxation (HP:0003308)2.02421578
92Generalized myoclonic seizures (HP:0002123)2.01667482
93Pheochromocytoma (HP:0002666)2.01667018
94Mildly elevated creatine phosphokinase (HP:0008180)1.98987590
95Atrophic scars (HP:0001075)1.98698848
96Bundle branch block (HP:0011710)1.98101972
97Craniofacial dystonia (HP:0012179)1.96747947
98Retinal dysplasia (HP:0007973)1.96002187
99Insidious onset (HP:0003587)1.95454816
100Termporal pattern (HP:0011008)1.95454816
101Ankle clonus (HP:0011448)1.95157413
102Severe visual impairment (HP:0001141)1.94985560
103Lower limb muscle weakness (HP:0007340)1.93934052
104Scotoma (HP:0000575)1.91849816
105Aortic regurgitation (HP:0001659)1.91139015
106Prolonged QT interval (HP:0001657)1.90942945
107Genu recurvatum (HP:0002816)1.90389370
108Bladder diverticulum (HP:0000015)1.89577413
109Generalized hypopigmentation of hair (HP:0011358)1.88329915
110Abnormal rod and cone electroretinograms (HP:0008323)1.88027747
111Syncope (HP:0001279)1.87866999
112Genital tract atresia (HP:0001827)1.86218236
113Akinesia (HP:0002304)1.85928092
114Agitation (HP:0000713)1.85456545
115Bradycardia (HP:0001662)1.84256395
116Cerebral aneurysm (HP:0004944)1.84202383
117Vaginal atresia (HP:0000148)1.82706070
118Osteolytic defects of the hand bones (HP:0009699)1.82316361
119Osteolytic defects of the phalanges of the hand (HP:0009771)1.82316361
120Torticollis (HP:0000473)1.82265467
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80580413
122Round ear (HP:0100830)1.80245295
123Fair hair (HP:0002286)1.79845638
124Bowel diverticulosis (HP:0005222)1.79809706
125Spastic gait (HP:0002064)1.78160046
126Mild short stature (HP:0003502)1.77984862
127Hyporeflexia of lower limbs (HP:0002600)1.77514323
128Gait ataxia (HP:0002066)1.77162243
129Cardiovascular calcification (HP:0011915)1.77084982
130Incomplete penetrance (HP:0003829)1.76745399
131Spinal cord compression (HP:0002176)1.76456474
132Upper limb amyotrophy (HP:0009129)1.75195248
133Distal upper limb amyotrophy (HP:0007149)1.75195248
134Abnormality of skeletal muscle fiber size (HP:0012084)1.74946044
135Fragile skin (HP:0001030)1.74142300
136Hyperparathyroidism (HP:0000843)1.73895752
137Bony spicule pigmentary retinopathy (HP:0007737)1.73831495
138Progressive inability to walk (HP:0002505)1.73308759
139Hemiplegia (HP:0002301)1.71607737
140Abnormal EKG (HP:0003115)1.71235549
141Hyperextensible skin (HP:0000974)1.70534926
142Esotropia (HP:0000565)1.70520292
143Abnormality of dentin (HP:0010299)1.70381008
144Apathy (HP:0000741)1.69737095
145Urinary urgency (HP:0000012)1.68916677
146Insomnia (HP:0100785)1.68772387
147Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68746522
148Neuroendocrine neoplasm (HP:0100634)1.68667814
149Thickened helices (HP:0000391)1.68648877
150Hypoventilation (HP:0002791)1.68521165
151Distal lower limb amyotrophy (HP:0008944)1.67629675
152Type II lissencephaly (HP:0007260)1.67073005
153Specific learning disability (HP:0001328)1.66361917
154Choroideremia (HP:0001139)1.65860067
155Abnormality of the lower motor neuron (HP:0002366)1.65749591
156Abnormal hair whorl (HP:0010721)1.65685709
157Buphthalmos (HP:0000557)1.64821381
158Abnormality of glycolipid metabolism (HP:0010969)1.64292862
159Abnormality of glycosphingolipid metabolism (HP:0004343)1.64292862
160Poor coordination (HP:0002370)1.64116839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.41374524
2NTRK34.11856661
3CASK3.49216422
4MAP3K43.25626148
5MAP2K72.96742287
6MAP3K92.84655124
7MARK12.46384868
8RIPK42.37276783
9MINK12.34050600
10MYLK2.33005963
11LATS22.32957860
12MAP3K122.11290664
13LIMK12.04911485
14DAPK22.03059725
15MAP2K41.95729487
16RIPK11.94312845
17PAK61.92306529
18PRPF4B1.88530162
19PLK21.84618617
20PNCK1.82159763
21TTN1.78916937
22NME11.78432933
23PTK21.71879624
24TNIK1.70922604
25TESK11.66691667
26PDGFRA1.63688860
27NTRK21.53912358
28DDR21.52838641
29DAPK11.51776975
30KSR21.46825273
31NTRK11.44765577
32AKT31.43663910
33KSR11.41963674
34MAP3K131.39771727
35GRK51.37556036
36INSRR1.37427616
37MAPK131.37130771
38BMPR21.35086120
39CDK51.29589886
40CAMKK21.29469471
41PRKD31.27120430
42FES1.25529872
43DMPK1.24121249
44CAMK2A1.21646662
45SIK21.19307686
46CAMKK11.17825700
47PAK21.17247466
48STK381.17025114
49MOS1.16516925
50PRKCG1.14748554
51ARAF1.09392738
52DYRK1A1.08949152
53PHKG11.04829567
54PHKG21.04829567
55MET1.02674661
56CAMK2B1.01808859
57SGK2231.01498067
58SGK4941.01498067
59CDK191.00318796
60PRKD20.99939194
61TRPM70.98266845
62SGK20.97684866
63WNK10.96172671
64CAMK2D0.94245616
65TRIB30.92899468
66PTK2B0.92812575
67CCNB10.91355273
68WNK30.90802428
69ROCK10.90166455
70CDK30.89349908
71OXSR10.89206970
72FER0.87965091
73CAMK10.83320872
74PBK0.81801004
75MAP3K20.81492757
76TNK20.79922309
77PRKCE0.79429524
78CAMK1G0.79307472
79PAK30.78011787
80SGK10.76307506
81ICK0.75501872
82PINK10.74131797
83SIK30.72250633
84CDK140.71059657
85CDK180.67167681
86RAF10.66543910
87MAP3K60.65563704
88UHMK10.64819323
89PRKG20.63386265
90CDK150.63062187
91PDGFRB0.63047480
92DAPK30.62749642
93MARK20.62269767
94PDPK10.60616820
95BRAF0.59511514
96FRK0.59239371
97RPS6KA20.58607896
98MST1R0.58496876
99CAMK1D0.56082947
100EPHA20.55682774
101FGR0.55074386
102GRK70.54728026
103PDK10.53699970
104STK110.52885313
105SGK30.52789847
106MAP3K10.52401485
107CDK11A0.52174180
108STK38L0.51773325
109EPHB10.50758859
110CDC42BPA0.48476185
111MTOR0.46808830
112MAP3K70.46687238
113BCR0.46459675
114LMTK20.46002637
115IRAK20.45520821
116FGFR20.45453396
117CAMK2G0.44976644
118RET0.44974235
119CSNK1G20.44888678
120ILK0.43672347
121PRKG10.43452266
122RPS6KA30.43227338
123PRKCZ0.42812211
124NEK10.42198230
125SIK10.42140518
126MAPK100.41104383
127ROCK20.40684165
128NEK60.40354196
129PRKCH0.39230179
130* PRKACA0.38150026
131MAPK120.37601001
132ADRBK10.35474253
133* PRKCA0.34794870
134MAP2K10.34064816

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.37860914
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39626608
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.12161157
4GABAergic synapse_Homo sapiens_hsa047272.98560585
5Circadian entrainment_Homo sapiens_hsa047132.83773681
6Morphine addiction_Homo sapiens_hsa050322.82391960
7Glutamatergic synapse_Homo sapiens_hsa047242.63171789
8Olfactory transduction_Homo sapiens_hsa047402.56983654
9Long-term potentiation_Homo sapiens_hsa047202.53971555
10Amphetamine addiction_Homo sapiens_hsa050312.36902387
11Taste transduction_Homo sapiens_hsa047422.31710812
12* Insulin secretion_Homo sapiens_hsa049112.18210941
13* Salivary secretion_Homo sapiens_hsa049702.14706894
14Dopaminergic synapse_Homo sapiens_hsa047282.12989542
15Collecting duct acid secretion_Homo sapiens_hsa049662.00279480
16Serotonergic synapse_Homo sapiens_hsa047261.97549874
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94407619
18Cholinergic synapse_Homo sapiens_hsa047251.85023601
19* Renin secretion_Homo sapiens_hsa049241.80179130
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75225358
21Long-term depression_Homo sapiens_hsa047301.73710782
22Oxytocin signaling pathway_Homo sapiens_hsa049211.69278131
23Calcium signaling pathway_Homo sapiens_hsa040201.66538111
24Gastric acid secretion_Homo sapiens_hsa049711.66438089
25Phototransduction_Homo sapiens_hsa047441.56997308
26Cocaine addiction_Homo sapiens_hsa050301.48229413
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46169220
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44705241
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37864103
30Vibrio cholerae infection_Homo sapiens_hsa051101.36132272
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30648234
32GnRH signaling pathway_Homo sapiens_hsa049121.28823598
33Circadian rhythm_Homo sapiens_hsa047101.25933608
34Gap junction_Homo sapiens_hsa045401.25763892
35cAMP signaling pathway_Homo sapiens_hsa040241.24865345
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23802838
37Cardiac muscle contraction_Homo sapiens_hsa042601.22587111
38Focal adhesion_Homo sapiens_hsa045101.19938864
39ECM-receptor interaction_Homo sapiens_hsa045121.19877524
40Type II diabetes mellitus_Homo sapiens_hsa049301.15203638
41* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11643604
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10177820
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07956812
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99730584
45Estrogen signaling pathway_Homo sapiens_hsa049150.97157977
46* Vascular smooth muscle contraction_Homo sapiens_hsa042700.97036393
47Axon guidance_Homo sapiens_hsa043600.90699460
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89034183
49* Pancreatic secretion_Homo sapiens_hsa049720.87888312
50Vitamin B6 metabolism_Homo sapiens_hsa007500.86999871
51Melanogenesis_Homo sapiens_hsa049160.83432152
52Dilated cardiomyopathy_Homo sapiens_hsa054140.82898749
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81734947
54Alzheimers disease_Homo sapiens_hsa050100.80388940
55Proteoglycans in cancer_Homo sapiens_hsa052050.79887649
56Oxidative phosphorylation_Homo sapiens_hsa001900.78574307
57ErbB signaling pathway_Homo sapiens_hsa040120.77163188
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.76872309
59Thyroid hormone synthesis_Homo sapiens_hsa049180.76519670
60Glioma_Homo sapiens_hsa052140.72718114
61Protein digestion and absorption_Homo sapiens_hsa049740.71564647
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71416766
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71116142
64Amoebiasis_Homo sapiens_hsa051460.65714633
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65636346
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.63748247
67Choline metabolism in cancer_Homo sapiens_hsa052310.63728384
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63143581
69Glucagon signaling pathway_Homo sapiens_hsa049220.62853860
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62648385
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62428050
72MAPK signaling pathway_Homo sapiens_hsa040100.62017029
73Inositol phosphate metabolism_Homo sapiens_hsa005620.59924749
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59566522
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59473495
76Tight junction_Homo sapiens_hsa045300.59257575
77Oocyte meiosis_Homo sapiens_hsa041140.56301559
78Endocytosis_Homo sapiens_hsa041440.53824078
79AMPK signaling pathway_Homo sapiens_hsa041520.51256213
80Hippo signaling pathway_Homo sapiens_hsa043900.51247847
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51056063
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50946464
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50821898
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50413913
85Dorso-ventral axis formation_Homo sapiens_hsa043200.49677692
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.49669128
87Ras signaling pathway_Homo sapiens_hsa040140.48611527
88Alcoholism_Homo sapiens_hsa050340.47859952
89Adherens junction_Homo sapiens_hsa045200.47201530
90Lysosome_Homo sapiens_hsa041420.46634286
91Rheumatoid arthritis_Homo sapiens_hsa053230.45762510
92Other glycan degradation_Homo sapiens_hsa005110.45631226
93Sphingolipid metabolism_Homo sapiens_hsa006000.45348561
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45286874
95African trypanosomiasis_Homo sapiens_hsa051430.44138159
96Ovarian steroidogenesis_Homo sapiens_hsa049130.41416774
97Melanoma_Homo sapiens_hsa052180.41252854
98Parkinsons disease_Homo sapiens_hsa050120.39732594
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39050375
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37471265
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36534896
102Mineral absorption_Homo sapiens_hsa049780.36498977
103Wnt signaling pathway_Homo sapiens_hsa043100.36239708
104Type I diabetes mellitus_Homo sapiens_hsa049400.34228448
105mTOR signaling pathway_Homo sapiens_hsa041500.34119595
106VEGF signaling pathway_Homo sapiens_hsa043700.33671149
107Rap1 signaling pathway_Homo sapiens_hsa040150.33539468
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33461276
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.32576683
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30032929
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29992752
112Bile secretion_Homo sapiens_hsa049760.27648773
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.27529969
114Huntingtons disease_Homo sapiens_hsa050160.27163764
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.24481734
116Prion diseases_Homo sapiens_hsa050200.23188389
117Regulation of autophagy_Homo sapiens_hsa041400.22942173
118Renal cell carcinoma_Homo sapiens_hsa052110.22935367
119Insulin signaling pathway_Homo sapiens_hsa049100.20894906
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20880537
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20780697
122Phagosome_Homo sapiens_hsa041450.17350778

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »