KCNMB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.05168941
2polyketide metabolic process (GO:0030638)6.05168941
3doxorubicin metabolic process (GO:0044598)6.05168941
4negative regulation of calcium ion transport into cytosol (GO:0010523)5.87545370
5negative regulation of dendrite morphogenesis (GO:0050774)5.53292923
6peripheral nervous system neuron development (GO:0048935)5.49750371
7indole-containing compound catabolic process (GO:0042436)5.13292978
8indolalkylamine catabolic process (GO:0046218)5.13292978
9tryptophan catabolic process (GO:0006569)5.13292978
10behavioral response to nicotine (GO:0035095)5.07806892
11negative regulation of homotypic cell-cell adhesion (GO:0034111)4.99254770
12detection of temperature stimulus involved in sensory perception (GO:0050961)4.95283855
13detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.95283855
14kynurenine metabolic process (GO:0070189)4.71367495
15indolalkylamine metabolic process (GO:0006586)4.62846203
16tryptophan metabolic process (GO:0006568)4.37006482
17G-protein coupled receptor internalization (GO:0002031)4.33809096
18cellular response to ATP (GO:0071318)4.32637007
19detection of temperature stimulus (GO:0016048)4.32334133
20adenosine metabolic process (GO:0046085)4.30478641
21neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.15759585
22urinary tract smooth muscle contraction (GO:0014848)4.06673772
23negative regulation of heart rate (GO:0010459)3.96400992
24sulfation (GO:0051923)3.92428125
25regulation of platelet aggregation (GO:0090330)3.87638095
26fucose catabolic process (GO:0019317)3.77695964
27L-fucose metabolic process (GO:0042354)3.77695964
28L-fucose catabolic process (GO:0042355)3.77695964
29cellular biogenic amine catabolic process (GO:0042402)3.74174957
30amine catabolic process (GO:0009310)3.74174957
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.65447401
32indole-containing compound metabolic process (GO:0042430)3.60167525
33aminoglycoside antibiotic metabolic process (GO:0030647)3.51431290
34neuronal action potential (GO:0019228)3.49580544
35response to pheromone (GO:0019236)3.48062989
36energy homeostasis (GO:0097009)3.47580540
37detection of light stimulus involved in sensory perception (GO:0050962)3.42514054
38detection of light stimulus involved in visual perception (GO:0050908)3.42514054
39reflex (GO:0060004)3.38474210
40response to pain (GO:0048265)3.36075117
41positive regulation of macrophage differentiation (GO:0045651)3.32692485
42histamine secretion (GO:0001821)3.31846504
43gamma-aminobutyric acid transport (GO:0015812)3.30818033
44cellular ketone body metabolic process (GO:0046950)3.26955125
45negative regulation of dendrite development (GO:2000171)3.24092784
46behavioral response to pain (GO:0048266)3.22711101
47axoneme assembly (GO:0035082)3.17176356
48NAD biosynthetic process (GO:0009435)3.15589385
49neuron fate specification (GO:0048665)3.14103354
50regulation of cell communication by electrical coupling (GO:0010649)3.12887798
51superoxide anion generation (GO:0042554)3.11630502
52cAMP catabolic process (GO:0006198)3.11109250
53regulation of relaxation of muscle (GO:1901077)3.09782066
54primary amino compound metabolic process (GO:1901160)3.09016173
55platelet dense granule organization (GO:0060155)3.06170566
56cilium or flagellum-dependent cell motility (GO:0001539)3.05844581
57DNA deamination (GO:0045006)3.01263678
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98375461
59serotonin metabolic process (GO:0042428)2.97462713
60monocyte chemotaxis (GO:0002548)2.96796180
61positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.95525151
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95239277
63negative regulation of systemic arterial blood pressure (GO:0003085)2.93063846
64ketone body metabolic process (GO:1902224)2.92313855
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91990173
66detection of calcium ion (GO:0005513)2.89492511
67presynaptic membrane assembly (GO:0097105)2.88768079
68cyclic nucleotide catabolic process (GO:0009214)2.87592271
69negative regulation of telomere maintenance (GO:0032205)2.86823596
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86349887
71negative regulation of translation, ncRNA-mediated (GO:0040033)2.86349887
72regulation of translation, ncRNA-mediated (GO:0045974)2.86349887
73detection of molecule of bacterial origin (GO:0032490)2.85315965
74negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.85071435
75positive regulation of muscle hypertrophy (GO:0014742)2.84565225
76positive regulation of cardiac muscle hypertrophy (GO:0010613)2.84565225
77water-soluble vitamin biosynthetic process (GO:0042364)2.82431279
78phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81973044
79positive regulation of action potential (GO:0045760)2.80260343
80aromatic amino acid family catabolic process (GO:0009074)2.78763188
81benzene-containing compound metabolic process (GO:0042537)2.78471595
82metanephric mesenchyme development (GO:0072075)2.77776581
83behavioral response to ethanol (GO:0048149)2.77568015
84photoreceptor cell maintenance (GO:0045494)2.77497855
85piRNA metabolic process (GO:0034587)2.76850081
86multicellular organism reproduction (GO:0032504)2.76136121
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74730670
88auditory receptor cell stereocilium organization (GO:0060088)2.74547115
89transmission of nerve impulse (GO:0019226)2.73597433
90negative regulation of bone resorption (GO:0045779)2.72576461
91histamine transport (GO:0051608)2.72276341
92regulation of pigment cell differentiation (GO:0050932)2.71649796
93negative regulation of smooth muscle contraction (GO:0045986)2.71498587
94opioid receptor signaling pathway (GO:0038003)2.70678862
95positive regulation of defense response to virus by host (GO:0002230)2.70329978
96sympathetic nervous system development (GO:0048485)2.70134343
97protein import into peroxisome matrix (GO:0016558)2.68677506
98positive regulation of steroid hormone secretion (GO:2000833)2.66578145
99regulation of homotypic cell-cell adhesion (GO:0034110)2.65417171
100negative regulation of stem cell proliferation (GO:2000647)2.64704163
101dopamine transport (GO:0015872)2.64355873
102positive regulation of uterine smooth muscle contraction (GO:0070474)2.64139775
103serotonin receptor signaling pathway (GO:0007210)2.63872038
104extracellular regulation of signal transduction (GO:1900115)2.63708277
105extracellular negative regulation of signal transduction (GO:1900116)2.63708277
106tachykinin receptor signaling pathway (GO:0007217)2.62629818
107epithelial cilium movement (GO:0003351)2.61860860
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61798951
109positive regulation of cAMP-mediated signaling (GO:0043950)2.61390500
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60409230
111preassembly of GPI anchor in ER membrane (GO:0016254)2.60026505
112inner ear receptor stereocilium organization (GO:0060122)2.59368910
113cell proliferation in forebrain (GO:0021846)2.59298850
114cranial nerve development (GO:0021545)2.58971381
115regulation of sarcomere organization (GO:0060297)2.57264635
116negative regulation of platelet activation (GO:0010544)2.57068422
117response to ATP (GO:0033198)2.56377802
118nonmotile primary cilium assembly (GO:0035058)2.56027659
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.53744732
120regulation of action potential (GO:0098900)2.53245824
121rRNA catabolic process (GO:0016075)2.52066304
122sequestering of extracellular ligand from receptor (GO:0035581)2.51227901
123peristalsis (GO:0030432)2.51203429
124detection of mechanical stimulus involved in sensory perception (GO:0050974)2.50970556
125negative regulation of protein oligomerization (GO:0032460)2.49814768
126negative regulation of mast cell activation (GO:0033004)2.49717136
127bundle of His cell to Purkinje myocyte communication (GO:0086069)2.49691610
128cellular response to exogenous dsRNA (GO:0071360)2.49566884
129regulation of cardiac muscle hypertrophy (GO:0010611)2.49271130
130positive regulation of mitochondrial fission (GO:0090141)2.49148575
131rhodopsin mediated signaling pathway (GO:0016056)2.48803648
132positive regulation of cellular amide metabolic process (GO:0034250)2.48626053
133adaptation of signaling pathway (GO:0023058)2.48509140
134presynaptic membrane organization (GO:0097090)2.47362344
135negative regulation of striated muscle cell apoptotic process (GO:0010664)2.47164185
136regulation of activation of Janus kinase activity (GO:0010533)2.44416889
137prostate gland growth (GO:0060736)2.43479915
138mitochondrial respiratory chain complex I assembly (GO:0032981)2.43208838
139NADH dehydrogenase complex assembly (GO:0010257)2.43208838
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43208838
141positive regulation of fatty acid transport (GO:2000193)2.42966521
142kidney mesenchyme development (GO:0072074)2.42746079
143cellular response to nicotine (GO:0071316)2.42039881
144regulation of fever generation (GO:0031620)2.41965619
145sperm motility (GO:0030317)2.41591972
146signal peptide processing (GO:0006465)2.41326353
147protein polyglutamylation (GO:0018095)2.41271515
148regulation of memory T cell differentiation (GO:0043380)2.40820518
149regulation of cilium movement (GO:0003352)2.40483340
150regulation of neurotransmitter uptake (GO:0051580)2.39330655
151appendage development (GO:0048736)2.38615001
152limb development (GO:0060173)2.38615001
153retinal cone cell development (GO:0046549)2.38324481
154regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37953340
155aromatic amino acid family metabolic process (GO:0009072)2.37365396
156regulation of muscle hypertrophy (GO:0014743)2.36825146
157positive regulation of mast cell activation (GO:0033005)2.36192078
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.35877963
1593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.35877963
160negative regulation of synaptic transmission, GABAergic (GO:0032229)2.35452216
161proline transport (GO:0015824)2.34004850
162positive regulation of interleukin-1 production (GO:0032732)2.33303615
163spinal cord motor neuron differentiation (GO:0021522)2.32963495
164action potential (GO:0001508)2.32424099
165negative regulation of cAMP-mediated signaling (GO:0043951)2.32221597
166regulation of gene silencing by RNA (GO:0060966)2.32147583
167regulation of posttranscriptional gene silencing (GO:0060147)2.32147583
168regulation of gene silencing by miRNA (GO:0060964)2.32147583
169positive regulation of vascular permeability (GO:0043117)2.31578248
170protein localization to cilium (GO:0061512)2.31472544
171regulation of hippo signaling (GO:0035330)2.31446278
172cilium movement (GO:0003341)2.31088861
173retinal ganglion cell axon guidance (GO:0031290)2.30566624
174purinergic nucleotide receptor signaling pathway (GO:0035590)2.30331561
175photoreceptor cell development (GO:0042461)2.27744446
176positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.27599158
177thyroid hormone metabolic process (GO:0042403)2.27551694
178cellular response to gamma radiation (GO:0071480)2.27066623
179mechanoreceptor differentiation (GO:0042490)2.26175967
180negative regulation of myoblast differentiation (GO:0045662)2.26090157
181membrane depolarization during action potential (GO:0086010)2.24479691
182positive regulation of heat generation (GO:0031652)2.24339417
183activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.24152688
184positive regulation of synaptic transmission, GABAergic (GO:0032230)2.21407615
185regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.21264155
186DNA integration (GO:0015074)2.21160094
187intraciliary transport (GO:0042073)2.21136780
188positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.20373893
189cellular response to alkaloid (GO:0071312)2.18557793
190regulation of glucokinase activity (GO:0033131)2.17822947
191regulation of hexokinase activity (GO:1903299)2.17822947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.01604378
2ZNF274_21170338_ChIP-Seq_K562_Hela3.29922346
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.78359569
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71349076
5EZH2_22144423_ChIP-Seq_EOC_Human2.66433431
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.49917496
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43609094
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25121186
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.16390652
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06977159
11P300_19829295_ChIP-Seq_ESCs_Human2.06016696
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99173312
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97628760
14SUZ12_27294783_Chip-Seq_NPCs_Mouse1.96310168
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96172957
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96167607
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92361698
18VDR_22108803_ChIP-Seq_LS180_Human1.86918698
19* SMAD4_21799915_ChIP-Seq_A2780_Human1.84721213
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.81720160
21IGF1R_20145208_ChIP-Seq_DFB_Human1.81224492
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81158409
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81085675
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.80207183
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.78784976
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.78314233
27E2F1_18555785_Chip-Seq_ESCs_Mouse1.77332913
28BCAT_22108803_ChIP-Seq_LS180_Human1.72581275
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72381831
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.70758972
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.69991784
32STAT3_18555785_Chip-Seq_ESCs_Mouse1.68056570
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66028043
34P53_22387025_ChIP-Seq_ESCs_Mouse1.64535009
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.64440984
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61646125
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61425478
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.60689048
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60388931
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59877585
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.59359181
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59307585
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57319549
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56349865
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56349865
46NMYC_18555785_Chip-Seq_ESCs_Mouse1.55092637
47RNF2_27304074_Chip-Seq_NSC_Mouse1.54396275
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.54354479
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.53378186
50DROSHA_22980978_ChIP-Seq_HELA_Human1.52672743
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52210644
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51737825
53STAT3_23295773_ChIP-Seq_U87_Human1.51560595
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49552634
55CBP_20019798_ChIP-Seq_JUKART_Human1.47143192
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47143192
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45059660
58TAF15_26573619_Chip-Seq_HEK293_Human1.44484720
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43487595
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42750828
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.42679179
62SOX2_18555785_Chip-Seq_ESCs_Mouse1.42448406
63IRF1_19129219_ChIP-ChIP_H3396_Human1.41744926
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.40315898
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40238007
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39449046
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.39132866
68P300_18555785_Chip-Seq_ESCs_Mouse1.36970704
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36671944
70TCF4_23295773_ChIP-Seq_U87_Human1.35338481
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34939776
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.34661803
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34329892
74AR_25329375_ChIP-Seq_VCAP_Human1.30782865
75SOX2_19829295_ChIP-Seq_ESCs_Human1.30737787
76NANOG_19829295_ChIP-Seq_ESCs_Human1.30737787
77ZFX_18555785_Chip-Seq_ESCs_Mouse1.30506361
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30401434
79PU1_27457419_Chip-Seq_LIVER_Mouse1.28836702
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28058984
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27150697
82TCF4_22108803_ChIP-Seq_LS180_Human1.26961745
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.26916815
84* KDM2B_26808549_Chip-Seq_REH_Human1.26326458
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26106575
86RUNX2_22187159_ChIP-Seq_PCA_Human1.24139040
87CTCF_18555785_Chip-Seq_ESCs_Mouse1.23199894
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22596507
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.22063602
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21281109
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20830110
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.20830110
93TP53_22573176_ChIP-Seq_HFKS_Human1.20594885
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20430925
95KLF4_18555785_Chip-Seq_ESCs_Mouse1.19470259
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19058132
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18946797
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18936880
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18825974
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18825974
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.18566241
102TP53_18474530_ChIP-ChIP_U2OS_Human1.18332537
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.17942695
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.16711525
105REST_21632747_ChIP-Seq_MESCs_Mouse1.16243388
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.16176950
107MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16134581
108ER_23166858_ChIP-Seq_MCF-7_Human1.15191629
109* JUN_21703547_ChIP-Seq_K562_Human1.14524989
110* CRX_20693478_ChIP-Seq_RETINA_Mouse1.14114750
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14007472
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13404661
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12991797
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12296419
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11962464
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11855491
117* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11789189
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11711062
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.11336063
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11231877
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10728940
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10400120
123EWS_26573619_Chip-Seq_HEK293_Human1.09869311
124AR_21572438_ChIP-Seq_LNCaP_Human1.09492948
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09064216
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09028609
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08421678
128FUS_26573619_Chip-Seq_HEK293_Human1.07757665
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07491879
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06735242
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06450000
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.05643154
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04518953
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04293916
135IRF8_21731497_ChIP-ChIP_J774_Mouse1.03580162
136AR_20517297_ChIP-Seq_VCAP_Human1.02834921
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02222335
138* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01362923
139CDX2_22108803_ChIP-Seq_LS180_Human0.99557403
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99315811
141NCOR_22424771_ChIP-Seq_293T_Human0.99131029
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98358534
143TP53_16413492_ChIP-PET_HCT116_Human0.97222324
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96664181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.07479487
2MP0002735_abnormal_chemical_nociception5.91851967
3MP0001968_abnormal_touch/_nociception4.18666076
4MP0006276_abnormal_autonomic_nervous3.71144394
5MP0002736_abnormal_nociception_after3.67727514
6MP0003195_calcinosis3.45588275
7MP0001188_hyperpigmentation3.39920094
8MP0009697_abnormal_copulation2.96180128
9MP0010386_abnormal_urinary_bladder2.81395001
10MP0005171_absent_coat_pigmentation2.76690353
11MP0000372_irregular_coat_pigmentation2.74141509
12MP0003136_yellow_coat_color2.65795906
13MP0003646_muscle_fatigue2.61502461
14MP0005551_abnormal_eye_electrophysiolog2.53054474
15MP0001501_abnormal_sleep_pattern2.47624188
16MP0002734_abnormal_mechanical_nocicepti2.26117220
17MP0000569_abnormal_digit_pigmentation2.21685449
18MP0001970_abnormal_pain_threshold2.17035823
19MP0005167_abnormal_blood-brain_barrier2.11494819
20MP0008872_abnormal_physiological_respon2.09265360
21MP0002733_abnormal_thermal_nociception2.08548821
22MP0005646_abnormal_pituitary_gland2.07748401
23MP0003880_abnormal_central_pattern2.04136825
24MP0008004_abnormal_stomach_pH2.02292822
25MP0002837_dystrophic_cardiac_calcinosis1.91211313
26MP0002277_abnormal_respiratory_mucosa1.78700726
27MP0008877_abnormal_DNA_methylation1.78301999
28MP0006292_abnormal_olfactory_placode1.73945531
29MP0002163_abnormal_gland_morphology1.72878926
30MP0005645_abnormal_hypothalamus_physiol1.72298487
31MP0004270_analgesia1.71805279
32MP0003011_delayed_dark_adaptation1.70062428
33MP0001485_abnormal_pinna_reflex1.68191265
34MP0000015_abnormal_ear_pigmentation1.66726975
35MP0005253_abnormal_eye_physiology1.65653336
36MP0002138_abnormal_hepatobiliary_system1.64982711
37MP0002254_reproductive_system_inflammat1.61716159
38MP0004858_abnormal_nervous_system1.59458408
39MP0006072_abnormal_retinal_apoptosis1.57361698
40MP0002653_abnormal_ependyma_morphology1.57061731
41MP0001542_abnormal_bone_strength1.55507214
42MP0002751_abnormal_autonomic_nervous1.55408658
43MP0006082_CNS_inflammation1.52783876
44MP0002876_abnormal_thyroid_physiology1.52781097
45MP0004043_abnormal_pH_regulation1.51946628
46MP0004885_abnormal_endolymph1.51668971
47MP0005410_abnormal_fertilization1.46305119
48MP0004782_abnormal_surfactant_physiolog1.40609620
49MP0001984_abnormal_olfaction1.39931190
50MP0005379_endocrine/exocrine_gland_phen1.39102097
51MP0001270_distended_abdomen1.37763842
52MP0004145_abnormal_muscle_electrophysio1.34742261
53MP0005084_abnormal_gallbladder_morpholo1.34365873
54MP0009764_decreased_sensitivity_to1.29219320
55MP0000681_abnormal_thyroid_gland1.24855088
56MP0002067_abnormal_sensory_capabilities1.24714014
57MP0000516_abnormal_urinary_system1.24399690
58MP0005367_renal/urinary_system_phenotyp1.24399690
59MP0002064_seizures1.24052347
60MP0008775_abnormal_heart_ventricle1.22632583
61MP0003122_maternal_imprinting1.22487873
62MP0000631_abnormal_neuroendocrine_gland1.22139825
63MP0000566_synostosis1.18200615
64MP0004484_altered_response_of1.17918312
65MP0000427_abnormal_hair_cycle1.13753865
66MP0003879_abnormal_hair_cell1.12321772
67MP0004147_increased_porphyrin_level1.11566968
68MP0001346_abnormal_lacrimal_gland1.11141493
69MP0001905_abnormal_dopamine_level1.11100500
70MP0002009_preneoplasia1.09079990
71MP0002184_abnormal_innervation1.08898828
72MP0002928_abnormal_bile_duct1.08249039
73MP0000678_abnormal_parathyroid_gland1.08074567
74MP0003787_abnormal_imprinting1.06524542
75MP0005310_abnormal_salivary_gland1.05867564
76MP0000749_muscle_degeneration1.05023248
77MP0004133_heterotaxia1.04890840
78MP0005409_darkened_coat_color1.03603836
79MP0008875_abnormal_xenobiotic_pharmacok1.02846400
80MP0003941_abnormal_skin_development1.02055394
81MP0003724_increased_susceptibility_to1.01260470
82MP0003045_fibrosis1.01072189
83MP0002160_abnormal_reproductive_system1.00735096
84MP0005195_abnormal_posterior_eye1.00636753
85MP0002938_white_spotting1.00405264
86MP0002132_abnormal_respiratory_system0.99346033
87MP0005174_abnormal_tail_pigmentation0.95295438
88MP0002272_abnormal_nervous_system0.95138762
89MP0002148_abnormal_hypersensitivity_rea0.95074771
90MP0001502_abnormal_circadian_rhythm0.93751673
91MP0003635_abnormal_synaptic_transmissio0.93610379
92MP0004510_myositis0.92726148
93MP0008260_abnormal_autophagy0.92130302
94MP0004742_abnormal_vestibular_system0.92000933
95MP0002229_neurodegeneration0.91071834
96MP0005448_abnormal_energy_balance0.90804028
97MP0001440_abnormal_grooming_behavior0.90403964
98MP0005670_abnormal_white_adipose0.90300238
99MP0004085_abnormal_heartbeat0.88007237
100MP0001873_stomach_inflammation0.87858259
101MP0008995_early_reproductive_senescence0.87402740
102MP0005257_abnormal_intraocular_pressure0.87142713
103MP0005647_abnormal_sex_gland0.86892733
104MP0004130_abnormal_muscle_cell0.86263181
105MP0002572_abnormal_emotion/affect_behav0.85362166
106MP0002638_abnormal_pupillary_reflex0.85288390
107MP0000538_abnormal_urinary_bladder0.83946182
108MP0000685_abnormal_immune_system0.83070686
109MP0002063_abnormal_learning/memory/cond0.82989295
110MP0002752_abnormal_somatic_nervous0.81929891
111MP0001800_abnormal_humoral_immune0.80834739
112MP0003638_abnormal_response/metabolism_0.80077356
113MP0003183_abnormal_peptide_metabolism0.80005283
114MP0009745_abnormal_behavioral_response0.78843500
115MP0005386_behavior/neurological_phenoty0.78776828
116MP0004924_abnormal_behavior0.78776828
117MP0001963_abnormal_hearing_physiology0.78549218
118MP0003698_abnormal_male_reproductive0.77812240
119MP0005377_hearing/vestibular/ear_phenot0.77731118
120MP0003878_abnormal_ear_physiology0.77731118
121MP0002972_abnormal_cardiac_muscle0.77021282
122MP0001664_abnormal_digestion0.76650467
123MP0003950_abnormal_plasma_membrane0.76208163
124MP0002127_abnormal_cardiovascular_syste0.75718063
125MP0005389_reproductive_system_phenotype0.75683169
126MP0002557_abnormal_social/conspecific_i0.75640284
127MP0009785_altered_susceptibility_to0.75634400
128MP0001790_abnormal_immune_system0.75601956
129MP0005387_immune_system_phenotype0.75601956
130MP0000026_abnormal_inner_ear0.74690929
131MP0003828_pulmonary_edema0.72124612
132MP0009780_abnormal_chondrocyte_physiolo0.71015303
133MP0002998_abnormal_bone_remodeling0.70967305
134MP0004036_abnormal_muscle_relaxation0.69972931
135MP0000049_abnormal_middle_ear0.69278717
136MP0004084_abnormal_cardiac_muscle0.66488117
137MP0005671_abnormal_response_to0.64949201
138MP0009046_muscle_twitch0.64437124
139MP0001919_abnormal_reproductive_system0.63572138
140MP0002693_abnormal_pancreas_physiology0.63270954
141* MP0000230_abnormal_systemic_arterial0.58846899
142MP0005165_increased_susceptibility_to0.56425537
143MP0002396_abnormal_hematopoietic_system0.54023337
144MP0004215_abnormal_myocardial_fiber0.53765822
145MP0002102_abnormal_ear_morphology0.51720716
146MP0004134_abnormal_chest_morphology0.51642737
147MP0002249_abnormal_larynx_morphology0.51598363
148MP0008058_abnormal_DNA_repair0.50288558
149MP0001486_abnormal_startle_reflex0.49283997
150MP0001186_pigmentation_phenotype0.48530013
151MP0004142_abnormal_muscle_tone0.48015846
152MP0002095_abnormal_skin_pigmentation0.47895576

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.16553932
2Genetic anticipation (HP:0003743)4.00257437
3Congenital stationary night blindness (HP:0007642)3.98451628
4Abnormality of midbrain morphology (HP:0002418)3.92118080
5Molar tooth sign on MRI (HP:0002419)3.92118080
6Abolished electroretinogram (ERG) (HP:0000550)3.73355216
7Abnormal hair whorl (HP:0010721)3.71462880
8Febrile seizures (HP:0002373)3.67542194
9Progressive cerebellar ataxia (HP:0002073)3.51572161
10Attenuation of retinal blood vessels (HP:0007843)3.43350486
11Abnormal ciliary motility (HP:0012262)3.42441409
12True hermaphroditism (HP:0010459)3.42076416
13Gaze-evoked nystagmus (HP:0000640)3.27798431
14Arthropathy (HP:0003040)3.25225376
15Pancreatic fibrosis (HP:0100732)3.21652940
16Hyperventilation (HP:0002883)3.19047139
17Recurrent corneal erosions (HP:0000495)3.12833060
18Abnormal respiratory motile cilium physiology (HP:0012261)3.12674374
19Tubulointerstitial nephritis (HP:0001970)3.06992277
20Abnormal respiratory epithelium morphology (HP:0012253)3.06481951
21Abnormal respiratory motile cilium morphology (HP:0005938)3.06481951
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05533221
23Pendular nystagmus (HP:0012043)3.03155614
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.01641805
25Type II lissencephaly (HP:0007260)3.00625200
26Distal lower limb muscle weakness (HP:0009053)2.93143000
27Increased corneal curvature (HP:0100692)2.82772546
28Keratoconus (HP:0000563)2.82772546
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.80428041
30Absent/shortened dynein arms (HP:0200106)2.80428041
31Medial flaring of the eyebrow (HP:0010747)2.78417875
32Prostate neoplasm (HP:0100787)2.77323026
33Abnormal rod and cone electroretinograms (HP:0008323)2.76431798
34Patchy hypopigmentation of hair (HP:0011365)2.75126816
35Nephrogenic diabetes insipidus (HP:0009806)2.74878559
36White forelock (HP:0002211)2.73175965
37Abnormality of dental color (HP:0011073)2.71376048
38Polydipsia (HP:0001959)2.71156677
39Abnormal drinking behavior (HP:0030082)2.71156677
40Bradycardia (HP:0001662)2.70683913
41Dysautonomia (HP:0002459)2.67946114
42Submucous cleft hard palate (HP:0000176)2.64149377
43Chromsome breakage (HP:0040012)2.60028769
44Anhidrosis (HP:0000970)2.55986715
45Clumsiness (HP:0002312)2.52947042
46Renal cortical cysts (HP:0000803)2.50583972
47Large for gestational age (HP:0001520)2.49461119
48Tubular atrophy (HP:0000092)2.48531370
49Stomach cancer (HP:0012126)2.47144913
50Hypoplasia of the fovea (HP:0007750)2.46832704
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.46832704
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46620847
53Congenital, generalized hypertrichosis (HP:0004540)2.46078175
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45198945
55Decreased circulating renin level (HP:0003351)2.44129008
56Chorioretinal atrophy (HP:0000533)2.43454547
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43046739
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.43007361
59Inability to walk (HP:0002540)2.42720242
60Sclerocornea (HP:0000647)2.42685029
61Abnormality of the right ventricle (HP:0001707)2.42491194
62Septo-optic dysplasia (HP:0100842)2.39396514
63Median cleft lip (HP:0000161)2.38932036
64Rhinitis (HP:0012384)2.37285952
65Abnormality of alanine metabolism (HP:0010916)2.36952552
66Hyperalaninemia (HP:0003348)2.36952552
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36952552
68Ulnar claw (HP:0001178)2.35765813
69Congenital primary aphakia (HP:0007707)2.35579364
70Abnormality of incisor morphology (HP:0011063)2.34308794
71Absent eyebrow (HP:0002223)2.34067737
72Increased IgM level (HP:0003496)2.33257331
73Furrowed tongue (HP:0000221)2.32094923
74Cerebellar dysplasia (HP:0007033)2.31351029
75Diplopia (HP:0000651)2.28184904
76Abnormality of binocular vision (HP:0011514)2.28184904
77Bony spicule pigmentary retinopathy (HP:0007737)2.28011526
78Gait imbalance (HP:0002141)2.27780445
79Hemiparesis (HP:0001269)2.27642184
80Atrial fibrillation (HP:0005110)2.26281281
81Congenital sensorineural hearing impairment (HP:0008527)2.25309025
82Congenital hepatic fibrosis (HP:0002612)2.24873940
83Optic nerve hypoplasia (HP:0000609)2.24794429
84Thyroid carcinoma (HP:0002890)2.24379509
85Stomatitis (HP:0010280)2.24217336
86Agitation (HP:0000713)2.23394486
87Alveolar cell carcinoma (HP:0006519)2.23033393
88Pancreatic cysts (HP:0001737)2.22648359
89Autoamputation (HP:0001218)2.20074415
90Protruding tongue (HP:0010808)2.18688240
91Methylmalonic acidemia (HP:0002912)2.15650231
92Abnormality of macular pigmentation (HP:0008002)2.14373239
93Osteomalacia (HP:0002749)2.13796881
94Anencephaly (HP:0002323)2.13369991
95Thyroid-stimulating hormone excess (HP:0002925)2.12707004
96Aplasia cutis congenita (HP:0001057)2.11731308
97Polyuria (HP:0000103)2.11084489
98Broad-based gait (HP:0002136)2.11048821
99Type I transferrin isoform profile (HP:0003642)2.09552008
100Progressive inability to walk (HP:0002505)2.08892718
101Focal motor seizures (HP:0011153)2.08334136
102Steppage gait (HP:0003376)2.08211602
103Aplasia/Hypoplasia of the tibia (HP:0005772)2.05723965
104Chronic hepatic failure (HP:0100626)2.04816785
105Primary atrial arrhythmia (HP:0001692)2.04072122
106Methylmalonic aciduria (HP:0012120)2.03509326
1073-Methylglutaconic aciduria (HP:0003535)2.02761608
108Severe visual impairment (HP:0001141)2.02401217
109Abnormality of the ischium (HP:0003174)2.02076440
110Genital tract atresia (HP:0001827)2.01630682
111Cystic liver disease (HP:0006706)2.00915627
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.00359909
113Abnormality of the fovea (HP:0000493)2.00314603
114Mesomelia (HP:0003027)2.00003814
115Alopecia of scalp (HP:0002293)1.99177110
116Retrobulbar optic neuritis (HP:0100654)1.97890912
117Optic neuritis (HP:0100653)1.97890912
118Duplicated collecting system (HP:0000081)1.97006468
119Abnormality of B cell number (HP:0010975)1.91513717
120Keratitis (HP:0000491)1.91176278
121Abnormal biliary tract physiology (HP:0012439)1.91069234
122Bile duct proliferation (HP:0001408)1.91069234
123Cheilitis (HP:0100825)1.90743430
124Occipital encephalocele (HP:0002085)1.90472658
125Hypoplasia of the pons (HP:0012110)1.89253667
126Epileptic encephalopathy (HP:0200134)1.89249042
127Vaginal atresia (HP:0000148)1.89178143
128Retinal dysplasia (HP:0007973)1.89137629
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.89100519
130Autoimmune thrombocytopenia (HP:0001973)1.87939667
131Supraventricular tachycardia (HP:0004755)1.87815138
132Barrel-shaped chest (HP:0001552)1.87374168
133Unilateral renal agenesis (HP:0000122)1.87257458
134Abnormality of calcium-phosphate metabolism (HP:0100530)1.86596865
135Abnormality of the pons (HP:0007361)1.86546236
136Lissencephaly (HP:0001339)1.85989678
137Absent speech (HP:0001344)1.85341233
138Nephronophthisis (HP:0000090)1.85232797
139Aplasia/Hypoplasia of the lens (HP:0008063)1.84857860
140Asplenia (HP:0001746)1.84423033
141Postaxial foot polydactyly (HP:0001830)1.84149779
142Increased cerebral lipofuscin (HP:0011813)1.82983207
143Abnormality of the nasal septum (HP:0000419)1.82158380
144Severe muscular hypotonia (HP:0006829)1.81882107
145Decreased central vision (HP:0007663)1.81611238
146Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81125007
147Fair hair (HP:0002286)1.80408751
148Male pseudohermaphroditism (HP:0000037)1.80194132
149Poor coordination (HP:0002370)1.79903226
150Abnormality of the renal medulla (HP:0100957)1.79763709
151Dialeptic seizures (HP:0011146)1.79359925
152Macular degeneration (HP:0000608)1.78193827
153Supraventricular arrhythmia (HP:0005115)1.77995876
154Hemiplegia (HP:0002301)1.77132172
155Abnormality of the renal collecting system (HP:0004742)1.76610124
156Thyroiditis (HP:0100646)1.75383154
157Popliteal pterygium (HP:0009756)1.74816430
158Adactyly (HP:0009776)1.74684274
159Neoplasm of the tracheobronchial system (HP:0100552)1.73583596
160Preaxial hand polydactyly (HP:0001177)1.70563585
161Progressive sensorineural hearing impairment (HP:0000408)1.69782708
162Upper limb muscle weakness (HP:0003484)1.69603111
163Conjugated hyperbilirubinemia (HP:0002908)1.69427166
164Abnormality of the renal cortex (HP:0011035)1.69383588
165Hypomagnesemia (HP:0002917)1.67792023
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66970989
167Supernumerary spleens (HP:0009799)1.65459586
168Oligohydramnios (HP:0001562)1.65417670
169Reduced antithrombin III activity (HP:0001976)1.65389819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.49921103
2SIK34.17654759
3ACVR1B3.14461742
4MYLK2.65739110
5ZAK2.59324644
6MATK2.58116365
7AKT32.51861932
8STK38L2.44372060
9ADRBK22.38607730
10STK242.32371205
11MAP4K22.26096202
12YES12.20635161
13MAP3K142.16832784
14PRPF4B2.12186533
15INSRR2.10224042
16SGK22.07801192
17NTRK12.05780622
18TXK1.96299573
19WNK31.93614263
20CDK81.90180696
21OBSCN1.71206226
22IRAK31.71143050
23MAPK151.66869917
24TLK11.65485849
25WNK41.63734420
26PINK11.60403388
27MAP3K121.53289006
28MAP2K71.51739532
29MARK31.49354827
30SGK2231.46322482
31SGK4941.46322482
32DAPK21.42557946
33KIT1.42442684
34BMPR1B1.40077394
35TRPM71.37365395
36BCR1.37215000
37TNIK1.31835088
38PIM21.30176204
39BMPR21.28926359
40FRK1.26975060
41MAPK131.26192137
42RIPK41.22401967
43OXSR11.20979154
44TGFBR11.19734247
45TEC1.15461463
46CDC42BPA1.12789803
47EPHA31.11107939
48NUAK11.11008410
49PRKCE1.10220907
50PTK2B1.08781939
51IRAK41.06936768
52SGK31.06821130
53PLK21.06176515
54CAMKK21.04254342
55MAP3K41.02244443
56NTRK31.01015081
57NLK1.00535520
58TIE10.99156192
59STK30.95794827
60ITK0.93525964
61GRK50.93450449
62EIF2AK20.93058612
63ERBB30.92111484
64STK390.89715697
65PRKCG0.89190095
66BCKDK0.87359700
67MINK10.86674249
68NEK60.82860935
69PKN10.79771880
70MST40.79403878
71SIK20.76687242
72NEK90.74272406
73SYK0.73897758
74MUSK0.73324466
75PNCK0.72820787
76RPS6KA20.72738853
77PAK30.72109418
78IRAK10.71431789
79BRAF0.69524590
80MAPKAPK30.67466502
81GRK10.65621602
82PIK3CG0.62100717
83BTK0.60878052
84PIK3CA0.60797655
85JAK30.60775243
86MAP3K60.60442517
87MKNK20.57952694
88PRKCQ0.56685982
89TAOK30.54119915
90CAMKK10.53826504
91PRKAA20.53298578
92IRAK20.52092790
93BLK0.51750656
94PRKG20.51537556
95ADRBK10.51527941
96ERBB20.51297698
97STK160.50759161
98CAMK1D0.50157483
99RPS6KL10.49709743
100RPS6KC10.49709743
101MARK10.49450895
102FGFR20.47798428
103CSF1R0.47425263
104TNK20.47376469
105PRKD20.46209335
106RPS6KA50.45803835
107DYRK20.45317147
108VRK10.44990394
109CSNK1A10.43541890
110RPS6KA60.42072829
111CAMK1G0.41680838
112CSNK1G20.41605611
113RPS6KB10.41370285
114FLT30.41267559
115MAP2K60.40989553
116MAPKAPK50.40928472
117FGFR30.40428946
118CDK30.40108332
119LCK0.40069272
120CAMK2A0.39789679
121STK110.39732927
122PRKCA0.39086567
123NTRK20.38703421
124CAMK10.38518117
125PRKG10.37861042
126IGF1R0.37776872
127ABL10.37196077
128MAP3K70.36675219
129PASK0.35550476
130FER0.35003690
131NEK20.34182831
132HIPK20.34032426
133PRKCH0.33577040
134LMTK20.32686743
135PRKACA0.32347010
136SGK10.31940883
137TAOK20.31002752
138GRK70.30404934
139PIM10.30301169
140MAP2K10.30026644
141IKBKB0.29008331
142IKBKE0.28654618
143JAK10.28440548
144CAMK2D0.27802030
145LYN0.25978287
146CHUK0.25924139
147MAPK30.25740935
148DMPK0.24842972

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42813658
2Linoleic acid metabolism_Homo sapiens_hsa005912.41875044
3Nitrogen metabolism_Homo sapiens_hsa009102.12562789
4Tryptophan metabolism_Homo sapiens_hsa003802.05141588
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97804217
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97182125
7Taste transduction_Homo sapiens_hsa047421.96277122
8Butanoate metabolism_Homo sapiens_hsa006501.91196790
9SNARE interactions in vesicular transport_Homo sapiens_hsa041301.89561695
10Rheumatoid arthritis_Homo sapiens_hsa053231.77408586
11Ether lipid metabolism_Homo sapiens_hsa005651.61422434
12Olfactory transduction_Homo sapiens_hsa047401.59829623
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57323931
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.54993641
15Autoimmune thyroid disease_Homo sapiens_hsa053201.50987639
16* Insulin secretion_Homo sapiens_hsa049111.49039700
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47135592
18ABC transporters_Homo sapiens_hsa020101.47035277
19Nicotine addiction_Homo sapiens_hsa050331.45356868
20Morphine addiction_Homo sapiens_hsa050321.41886506
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41706944
22Serotonergic synapse_Homo sapiens_hsa047261.39688031
23Hematopoietic cell lineage_Homo sapiens_hsa046401.34920596
24Allograft rejection_Homo sapiens_hsa053301.34123571
25Selenocompound metabolism_Homo sapiens_hsa004501.32250431
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32050841
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30429644
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27957013
29Circadian rhythm_Homo sapiens_hsa047101.25108561
30Fanconi anemia pathway_Homo sapiens_hsa034601.24621865
31Sphingolipid metabolism_Homo sapiens_hsa006001.24335321
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23201075
33Chemical carcinogenesis_Homo sapiens_hsa052041.23191445
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22285466
35Melanoma_Homo sapiens_hsa052181.21112210
36Collecting duct acid secretion_Homo sapiens_hsa049661.20942945
37Synaptic vesicle cycle_Homo sapiens_hsa047211.20625161
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18374580
39Phagosome_Homo sapiens_hsa041451.18069847
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.17509895
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.17315540
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16770758
43Circadian entrainment_Homo sapiens_hsa047131.15624903
44Graft-versus-host disease_Homo sapiens_hsa053321.15370591
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15298509
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.11274675
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11021908
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08590740
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08271062
50Calcium signaling pathway_Homo sapiens_hsa040201.06035090
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04610718
52Glycerolipid metabolism_Homo sapiens_hsa005611.04158323
53Type I diabetes mellitus_Homo sapiens_hsa049401.03127570
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02264641
55Staphylococcus aureus infection_Homo sapiens_hsa051501.02259350
56Retinol metabolism_Homo sapiens_hsa008301.00954019
57Caffeine metabolism_Homo sapiens_hsa002321.00283421
58Regulation of autophagy_Homo sapiens_hsa041400.98367948
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.97824076
60RNA polymerase_Homo sapiens_hsa030200.97791337
61Measles_Homo sapiens_hsa051620.96739728
62Protein export_Homo sapiens_hsa030600.96215833
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96083622
64Dilated cardiomyopathy_Homo sapiens_hsa054140.94075881
65Mineral absorption_Homo sapiens_hsa049780.93691682
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92188338
67Prolactin signaling pathway_Homo sapiens_hsa049170.91845600
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89788458
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89393562
70Arachidonic acid metabolism_Homo sapiens_hsa005900.88893544
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87241697
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86207094
73Peroxisome_Homo sapiens_hsa041460.84722649
74Vibrio cholerae infection_Homo sapiens_hsa051100.83558132
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83135991
76Basal transcription factors_Homo sapiens_hsa030220.82987461
77* Vascular smooth muscle contraction_Homo sapiens_hsa042700.82446500
78Ovarian steroidogenesis_Homo sapiens_hsa049130.79654696
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78286865
80Cholinergic synapse_Homo sapiens_hsa047250.77877772
81Dorso-ventral axis formation_Homo sapiens_hsa043200.76708419
82Parkinsons disease_Homo sapiens_hsa050120.75960969
83Thyroid cancer_Homo sapiens_hsa052160.75084949
84Cardiac muscle contraction_Homo sapiens_hsa042600.74948143
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74110084
86African trypanosomiasis_Homo sapiens_hsa051430.70684428
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70496214
88beta-Alanine metabolism_Homo sapiens_hsa004100.69387624
89Leishmaniasis_Homo sapiens_hsa051400.69131672
90Homologous recombination_Homo sapiens_hsa034400.69088449
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68827528
92Histidine metabolism_Homo sapiens_hsa003400.68800836
93Glutamatergic synapse_Homo sapiens_hsa047240.67973603
94Endometrial cancer_Homo sapiens_hsa052130.66962114
95Vitamin digestion and absorption_Homo sapiens_hsa049770.65504768
96Phototransduction_Homo sapiens_hsa047440.65242518
97TNF signaling pathway_Homo sapiens_hsa046680.64063571
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62013935
99* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60942248
100cAMP signaling pathway_Homo sapiens_hsa040240.60209327
101Oxytocin signaling pathway_Homo sapiens_hsa049210.60202643
102Salmonella infection_Homo sapiens_hsa051320.59520001
103Wnt signaling pathway_Homo sapiens_hsa043100.59319877
104GABAergic synapse_Homo sapiens_hsa047270.58959623
105Renin secretion_Homo sapiens_hsa049240.58827402
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58342720
107Influenza A_Homo sapiens_hsa051640.58056985
108ErbB signaling pathway_Homo sapiens_hsa040120.57543354
109MAPK signaling pathway_Homo sapiens_hsa040100.57179287
110Tuberculosis_Homo sapiens_hsa051520.57022253
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56507925
112Gastric acid secretion_Homo sapiens_hsa049710.56422661
113Sulfur metabolism_Homo sapiens_hsa009200.55325487
114Dopaminergic synapse_Homo sapiens_hsa047280.54978551
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54927304
116Ras signaling pathway_Homo sapiens_hsa040140.53387181
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52877300
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.52820377
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52568586
120Fat digestion and absorption_Homo sapiens_hsa049750.50867689
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.50446758
122Choline metabolism in cancer_Homo sapiens_hsa052310.49523784
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48680125
124Long-term depression_Homo sapiens_hsa047300.48114429
125RNA degradation_Homo sapiens_hsa030180.48041214
126Primary immunodeficiency_Homo sapiens_hsa053400.47992226
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47942776
128Huntingtons disease_Homo sapiens_hsa050160.47790008
129Propanoate metabolism_Homo sapiens_hsa006400.47707509
130Non-homologous end-joining_Homo sapiens_hsa034500.47423575
131Platelet activation_Homo sapiens_hsa046110.47281442
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46767046
133Melanogenesis_Homo sapiens_hsa049160.46444401
134Rap1 signaling pathway_Homo sapiens_hsa040150.45688274
135Oxidative phosphorylation_Homo sapiens_hsa001900.45496747
136Amphetamine addiction_Homo sapiens_hsa050310.45341705
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45117109
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45088874
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44568998
140Antigen processing and presentation_Homo sapiens_hsa046120.44438940
141Asthma_Homo sapiens_hsa053100.43822818
142Salivary secretion_Homo sapiens_hsa049700.43512832
143Purine metabolism_Homo sapiens_hsa002300.43484673
144Chemokine signaling pathway_Homo sapiens_hsa040620.43201691
145Cocaine addiction_Homo sapiens_hsa050300.42992391
146Type II diabetes mellitus_Homo sapiens_hsa049300.38957190
147Alzheimers disease_Homo sapiens_hsa050100.38214586
148One carbon pool by folate_Homo sapiens_hsa006700.33358392
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32947268

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