KCNMB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.81319093
2Golgi transport vesicle coating (GO:0048200)9.81319093
3endocrine pancreas development (GO:0031018)6.91544579
4peptide hormone processing (GO:0016486)6.27996169
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.19979876
6protein maturation by protein folding (GO:0022417)6.13790274
7signal peptide processing (GO:0006465)5.70278097
8COPII vesicle coating (GO:0048208)5.57573621
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.53897533
10regulation of type B pancreatic cell apoptotic process (GO:2000674)5.16826319
11glandular epithelial cell differentiation (GO:0002067)5.15612579
12insulin secretion (GO:0030073)5.11906232
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.08201058
14sequestering of metal ion (GO:0051238)5.04301253
15ER overload response (GO:0006983)5.01890257
16positive regulation of insulin secretion (GO:0032024)4.81619338
17protein retention in ER lumen (GO:0006621)4.67241091
18regulation of insulin secretion (GO:0050796)4.61822212
19type B pancreatic cell development (GO:0003323)4.58601102
20righting reflex (GO:0060013)4.53484274
21vesicle coating (GO:0006901)4.49538264
22exocrine pancreas development (GO:0031017)4.37455108
23water-soluble vitamin biosynthetic process (GO:0042364)4.33347977
24inositol phosphate catabolic process (GO:0071545)4.32316366
25glandular epithelial cell development (GO:0002068)4.31489634
26cellular ketone body metabolic process (GO:0046950)4.30813534
27regulation of peptide hormone secretion (GO:0090276)4.26281245
28dendritic spine morphogenesis (GO:0060997)4.22576259
29regulation of peptide secretion (GO:0002791)4.18607895
30activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.15537021
31positive regulation of peptide hormone secretion (GO:0090277)3.98559642
32positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.97595443
33inositol phosphate dephosphorylation (GO:0046855)3.96264998
34phosphorylated carbohydrate dephosphorylation (GO:0046838)3.96264998
35intra-Golgi vesicle-mediated transport (GO:0006891)3.96209024
36respiratory chain complex IV assembly (GO:0008535)3.93083543
37positive regulation of nuclease activity (GO:0032075)3.90717866
38negative regulation of execution phase of apoptosis (GO:1900118)3.89291160
39regulation of glucocorticoid secretion (GO:2000849)3.86488058
40positive regulation of peptide secretion (GO:0002793)3.85885157
41negative regulation of norepinephrine secretion (GO:0010700)3.85576023
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.81246632
43ketone body metabolic process (GO:1902224)3.79934710
44regulation of hormone secretion (GO:0046883)3.78139801
45intraciliary transport (GO:0042073)3.77503086
46cytochrome complex assembly (GO:0017004)3.74613194
47negative regulation of catecholamine secretion (GO:0033604)3.74481177
48peptide hormone secretion (GO:0030072)3.73003747
49peptide secretion (GO:0002790)3.64214639
50polyol catabolic process (GO:0046174)3.63454887
51glycerophospholipid catabolic process (GO:0046475)3.61633184
52positive regulation of glycolytic process (GO:0045821)3.59003146
53protein localization to cilium (GO:0061512)3.57590286
54toxin metabolic process (GO:0009404)3.54493314
55regulation of nuclease activity (GO:0032069)3.54399987
56nitric oxide mediated signal transduction (GO:0007263)3.53461099
57ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.52567450
58negative regulation of glycoprotein biosynthetic process (GO:0010561)3.51700505
59negative regulation of insulin secretion (GO:0046676)3.49160272
60protein localization to Golgi apparatus (GO:0034067)3.48244108
61cellular zinc ion homeostasis (GO:0006882)3.48107597
62columnar/cuboidal epithelial cell development (GO:0002066)3.47977892
63lactate metabolic process (GO:0006089)3.47759423
64ER to Golgi vesicle-mediated transport (GO:0006888)3.45998791
65cellular response to unfolded protein (GO:0034620)3.42956509
66endoplasmic reticulum unfolded protein response (GO:0030968)3.42793878
67regulation of peptide transport (GO:0090087)3.37516148
68cellular response to topologically incorrect protein (GO:0035967)3.37172916
69cellular response to glucagon stimulus (GO:0071377)3.34577129
70reflex (GO:0060004)3.33416187
71positive regulation of hormone secretion (GO:0046887)3.31052406
72cardiac left ventricle morphogenesis (GO:0003214)3.28793703
73protein prenylation (GO:0018342)3.27594098
74prenylation (GO:0097354)3.27594098
75proline transport (GO:0015824)3.27447533
76protein N-linked glycosylation via asparagine (GO:0018279)3.27042431
77ER-nucleus signaling pathway (GO:0006984)3.26926217
78peptidyl-asparagine modification (GO:0018196)3.25137903
79epithelial cell fate commitment (GO:0072148)3.17063304
80positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.16845580
81regulation of corticosteroid hormone secretion (GO:2000846)3.16825511
82negative regulation of peptide hormone secretion (GO:0090278)3.13158479
83regulation of hexokinase activity (GO:1903299)3.11507874
84regulation of glucokinase activity (GO:0033131)3.11507874
85cellular response to vitamin D (GO:0071305)3.10837889
86presynaptic membrane assembly (GO:0097105)3.09008228
87hormone secretion (GO:0046879)3.07703621
88regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.06452660
89negative regulation of peptide secretion (GO:0002792)3.00734604
90protein targeting to Golgi (GO:0000042)3.00496790
91protein N-linked glycosylation (GO:0006487)2.98378139
92* detection of calcium ion (GO:0005513)2.98065045
93regulation of penile erection (GO:0060405)2.96190068
94response to endoplasmic reticulum stress (GO:0034976)2.95040011
95protein complex biogenesis (GO:0070271)2.92395122
96hormone transport (GO:0009914)2.91567120
97pharyngeal system development (GO:0060037)2.91057828
98positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.90119013
99Golgi organization (GO:0007030)2.87859136
100artery smooth muscle contraction (GO:0014824)2.87606529
101somite development (GO:0061053)2.87338858
102brain morphogenesis (GO:0048854)2.86525589
103axoneme assembly (GO:0035082)2.86525583
104negative regulation of bone resorption (GO:0045779)2.86451503
105regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.86283512
106magnesium ion transport (GO:0015693)2.85802316
107peptide transport (GO:0015833)2.84639139
108response to pheromone (GO:0019236)2.84559397
109inner ear receptor cell development (GO:0060119)2.83727485
110presynaptic membrane organization (GO:0097090)2.82266797
111response to unfolded protein (GO:0006986)2.81116743
112Golgi vesicle transport (GO:0048193)2.79881579
113chemosensory behavior (GO:0007635)2.77833892
114adult feeding behavior (GO:0008343)2.77815529
115alanine transport (GO:0032328)2.77472486
116macroautophagy (GO:0016236)2.77283936
117response to hexose (GO:0009746)2.77178855
118establishment of protein localization to Golgi (GO:0072600)2.76011498
119negative regulation of neurological system process (GO:0031645)2.75409516
120phenylpropanoid metabolic process (GO:0009698)2.75361593
121regulation of oxidative phosphorylation (GO:0002082)2.75298999
122response to topologically incorrect protein (GO:0035966)2.74731708
123L-alpha-amino acid transmembrane transport (GO:1902475)2.72721929
124calcium ion import (GO:0070509)2.72515146
125response to glucose (GO:0009749)2.72324909
126astrocyte differentiation (GO:0048708)2.71889078
127interleukin-1-mediated signaling pathway (GO:0070498)2.71557109
128urinary tract smooth muscle contraction (GO:0014848)2.71206430
129glycosphingolipid biosynthetic process (GO:0006688)2.70511990
130kidney morphogenesis (GO:0060993)2.68835785
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.68578687
1323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.68578687
133regulation of calcium ion-dependent exocytosis (GO:0017158)2.68101009
134regulation of Golgi to plasma membrane protein transport (GO:0042996)2.67310294
135regulation of acrosome reaction (GO:0060046)2.67205774
136zinc ion transmembrane transport (GO:0071577)2.65550480
137growth hormone secretion (GO:0030252)2.65373393
138melanosome transport (GO:0032402)2.65196666
139pancreas development (GO:0031016)2.65168919
140positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.65055034
141cerebellar Purkinje cell layer development (GO:0021680)2.64888746
142dopamine transport (GO:0015872)2.64349554
143zinc ion homeostasis (GO:0055069)2.63286014
144regulation of energy homeostasis (GO:2000505)2.61870789
145L-phenylalanine catabolic process (GO:0006559)2.61277585
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61277585
147vascular smooth muscle contraction (GO:0014829)2.54876346
148mitochondrial respiratory chain complex assembly (GO:0033108)2.52023572
149dentate gyrus development (GO:0021542)2.51752236
150nucleobase catabolic process (GO:0046113)2.51112088
151nephron tubule morphogenesis (GO:0072078)2.49773490
152nephron epithelium morphogenesis (GO:0072088)2.49773490
153positive regulation of meiosis (GO:0045836)2.49090816
154negative regulation of protein oligomerization (GO:0032460)2.47953677
155positive regulation of gluconeogenesis (GO:0045722)2.47300917
156auditory behavior (GO:0031223)2.46837902
157positive regulation of neurotransmitter transport (GO:0051590)2.45654038
158renal tubule morphogenesis (GO:0061333)2.45599354
159positive regulation of amino acid transport (GO:0051957)2.45072808
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44175771
161prostate gland growth (GO:0060736)2.43978345
162Golgi to endosome transport (GO:0006895)2.43378457
163negative regulation of hormone biosynthetic process (GO:0032353)2.43352871
164positive regulation of histone H3-K4 methylation (GO:0051571)2.42813760
165positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.41937165
166epithelial cilium movement (GO:0003351)2.40197038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.48950942
2PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.06265168
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.05748433
4GBX2_23144817_ChIP-Seq_PC3_Human3.03949875
5EZH2_22144423_ChIP-Seq_EOC_Human2.98295395
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68610963
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.20838457
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.09131526
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04211534
10IGF1R_20145208_ChIP-Seq_DFB_Human1.92183502
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89913750
12ZNF274_21170338_ChIP-Seq_K562_Hela1.86439092
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83438453
14GATA1_22025678_ChIP-Seq_K562_Human1.77433708
15ER_23166858_ChIP-Seq_MCF-7_Human1.73509228
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70884354
17FUS_26573619_Chip-Seq_HEK293_Human1.70093866
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69931246
19* REST_18959480_ChIP-ChIP_MESCs_Mouse1.69919494
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69287505
21NR3C1_23031785_ChIP-Seq_PC12_Mouse1.69075570
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68179678
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.67403944
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66261931
25HTT_18923047_ChIP-ChIP_STHdh_Human1.65385527
26* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65339446
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64607634
28REST_19997604_ChIP-ChIP_NEURONS_Mouse1.63806921
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61648102
30* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58965849
31AR_25329375_ChIP-Seq_VCAP_Human1.58342397
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56495950
33SMAD4_21799915_ChIP-Seq_A2780_Human1.55133536
34* STAT3_23295773_ChIP-Seq_U87_Human1.53128236
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52682403
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52383730
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49919609
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.44355363
39* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43359469
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.41312180
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40320339
42VDR_22108803_ChIP-Seq_LS180_Human1.39597844
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39015191
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39000650
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38819228
46EWS_26573619_Chip-Seq_HEK293_Human1.38659352
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37325109
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32123028
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31413759
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29817488
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28159394
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26698404
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26418683
54* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25678734
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.24315328
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.24210878
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23844816
58CBP_20019798_ChIP-Seq_JUKART_Human1.23844816
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22428426
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22010685
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.20568286
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.18869661
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18321859
64* TCF4_23295773_ChIP-Seq_U87_Human1.18282724
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18200893
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17807222
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16633616
68* TCF4_22108803_ChIP-Seq_LS180_Human1.15614780
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.15112036
70LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14877475
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.14783890
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14629460
73P300_19829295_ChIP-Seq_ESCs_Human1.14207870
74CDX2_22108803_ChIP-Seq_LS180_Human1.14085560
75RUNX2_22187159_ChIP-Seq_PCA_Human1.13418276
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13109061
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12612737
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12163112
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12161839
80NANOG_19829295_ChIP-Seq_ESCs_Human1.12045976
81SOX2_19829295_ChIP-Seq_ESCs_Human1.12045976
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11547031
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10298429
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09728154
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09594094
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08577794
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08131388
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07922651
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.06666967
90* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06654271
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05873257
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05756748
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05683823
94P300_18555785_Chip-Seq_ESCs_Mouse1.05561229
95DROSHA_22980978_ChIP-Seq_HELA_Human1.05558644
96* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05547566
97* P53_22387025_ChIP-Seq_ESCs_Mouse1.05277939
98* STAT3_18555785_Chip-Seq_ESCs_Mouse1.05205106
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03446160
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02455383
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.01387360
102* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01262855
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01168040
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01140849
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.00917811
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99866951
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99866951
108* PRDM14_20953172_ChIP-Seq_ESCs_Human0.99094815
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98390167
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.98309902
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98240211
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98109984
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98079047
114CRX_20693478_ChIP-Seq_RETINA_Mouse0.98004840
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97800694
116PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97355945
117BCAT_22108803_ChIP-Seq_LS180_Human0.95577116
118SOX2_18555785_Chip-Seq_ESCs_Mouse0.95189342
119TAF15_26573619_Chip-Seq_HEK293_Human0.95163869
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.94281023
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93804447
122TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93375790
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.92511248
124* SMAD3_21741376_ChIP-Seq_ESCs_Human0.92246933
125* FOXA1_25552417_ChIP-Seq_VCAP_Human0.91731300
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.91693544
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91158385
128* SMAD3_21741376_ChIP-Seq_EPCs_Human0.90977469
129GF1B_26923725_Chip-Seq_HPCs_Mouse0.90885550
130SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89441192
131TP53_22573176_ChIP-Seq_HFKS_Human0.89323533
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.88890655
133RNF2_27304074_Chip-Seq_NSC_Mouse0.88534774
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88395989
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86648433
136AHR_22903824_ChIP-Seq_MCF-7_Human0.86636651
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85751970
138* AR_19668381_ChIP-Seq_PC3_Human0.85681448
139EED_16625203_ChIP-ChIP_MESCs_Mouse0.85357462
140* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84895084
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.84535833
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84535833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.83520631
2MP0000013_abnormal_adipose_tissue4.12049013
3MP0004043_abnormal_pH_regulation4.09697605
4MP0003283_abnormal_digestive_organ3.97422984
5MP0010386_abnormal_urinary_bladder3.90928154
6MP0009780_abnormal_chondrocyte_physiolo3.83290878
7MP0003183_abnormal_peptide_metabolism3.77037102
8MP0002693_abnormal_pancreas_physiology3.72889261
9MP0002909_abnormal_adrenal_gland3.70520803
10MP0002837_dystrophic_cardiac_calcinosis3.68749393
11MP0005379_endocrine/exocrine_gland_phen3.44467217
12MP0010234_abnormal_vibrissa_follicle3.40639088
13MP0001944_abnormal_pancreas_morphology3.39543942
14MP0000678_abnormal_parathyroid_gland3.15598686
15MP0003195_calcinosis2.91930238
16MP0008877_abnormal_DNA_methylation2.75938279
17MP0006072_abnormal_retinal_apoptosis2.44265816
18MP0005645_abnormal_hypothalamus_physiol2.43802487
19MP0005646_abnormal_pituitary_gland2.39343719
20MP0009046_muscle_twitch2.36079279
21MP0005220_abnormal_exocrine_pancreas2.31919205
22MP0002078_abnormal_glucose_homeostasis2.18154733
23MP0001986_abnormal_taste_sensitivity2.12549523
24MP0000003_abnormal_adipose_tissue2.04627776
25MP0003122_maternal_imprinting1.99178160
26MP0002638_abnormal_pupillary_reflex1.92939639
27MP0001984_abnormal_olfaction1.87796948
28MP0003880_abnormal_central_pattern1.83371657
29MP0004270_analgesia1.83003638
30MP0003787_abnormal_imprinting1.78088512
31MP0002876_abnormal_thyroid_physiology1.77557401
32MP0009745_abnormal_behavioral_response1.58673619
33MP0010678_abnormal_skin_adnexa1.58092769
34MP0000427_abnormal_hair_cycle1.51330777
35MP0002163_abnormal_gland_morphology1.50731701
36MP0000631_abnormal_neuroendocrine_gland1.49749352
37MP0002822_catalepsy1.44660744
38MP0002928_abnormal_bile_duct1.42872532
39MP0003123_paternal_imprinting1.42825549
40MP0001905_abnormal_dopamine_level1.41639405
41MP0002254_reproductive_system_inflammat1.41022566
42MP0002234_abnormal_pharynx_morphology1.39029027
43MP0001529_abnormal_vocalization1.38862480
44MP0001765_abnormal_ion_homeostasis1.36919472
45MP0005551_abnormal_eye_electrophysiolog1.36671342
46MP0002102_abnormal_ear_morphology1.35621444
47MP0003953_abnormal_hormone_level1.35315043
48MP0003011_delayed_dark_adaptation1.35288447
49MP0010329_abnormal_lipoprotein_level1.34358777
50MP0005332_abnormal_amino_acid1.33451002
51MP0002896_abnormal_bone_mineralization1.33360846
52MP0004924_abnormal_behavior1.26886820
53MP0005386_behavior/neurological_phenoty1.26886820
54MP0005058_abnormal_lysosome_morphology1.25877185
55MP0000462_abnormal_digestive_system1.24922473
56MP0005257_abnormal_intraocular_pressure1.23636411
57MP0000569_abnormal_digit_pigmentation1.21359850
58MP0001502_abnormal_circadian_rhythm1.21299054
59MP0002734_abnormal_mechanical_nocicepti1.20439423
60MP0004019_abnormal_vitamin_homeostasis1.15535348
61MP0000613_abnormal_salivary_gland1.14780795
62MP0004264_abnormal_extraembryonic_tissu1.14626817
63MP0005535_abnormal_body_temperature1.13866468
64MP0004859_abnormal_synaptic_plasticity1.10998304
65MP0001299_abnormal_eye_distance/1.10296488
66MP0004215_abnormal_myocardial_fiber1.09148307
67MP0002138_abnormal_hepatobiliary_system1.07372752
68MP0008961_abnormal_basal_metabolism1.06522873
69MP0006276_abnormal_autonomic_nervous1.04107822
70MP0003633_abnormal_nervous_system1.03342829
71MP0008057_abnormal_DNA_replication1.03095949
72MP0000383_abnormal_hair_follicle1.01815858
73MP0003890_abnormal_embryonic-extraembry1.00000102
74MP0006036_abnormal_mitochondrial_physio0.99663400
75MP0000681_abnormal_thyroid_gland0.98930629
76MP0003119_abnormal_digestive_system0.98697803
77MP0003879_abnormal_hair_cell0.98406245
78MP0003868_abnormal_feces_composition0.97812337
79MP0002557_abnormal_social/conspecific_i0.97534028
80MP0004885_abnormal_endolymph0.96459862
81MP0005253_abnormal_eye_physiology0.95397473
82MP0001486_abnormal_startle_reflex0.93334522
83MP0001968_abnormal_touch/_nociception0.93203259
84MP0003172_abnormal_lysosome_physiology0.92534198
85MP0002733_abnormal_thermal_nociception0.91486804
86MP0001270_distended_abdomen0.91209403
87MP0000538_abnormal_urinary_bladder0.91152236
88MP0003635_abnormal_synaptic_transmissio0.90537708
89MP0005448_abnormal_energy_balance0.88816260
90MP0003959_abnormal_lean_body0.88392669
91MP0002184_abnormal_innervation0.87049508
92MP0009643_abnormal_urine_homeostasis0.86972413
93MP0004133_heterotaxia0.86023604
94MP0002272_abnormal_nervous_system0.85340251
95MP0001756_abnormal_urination0.84988918
96MP0010352_gastrointestinal_tract_polyps0.84786017
97MP0005636_abnormal_mineral_homeostasis0.84566092
98MP0003121_genomic_imprinting0.84211958
99MP0002572_abnormal_emotion/affect_behav0.83301053
100MP0002160_abnormal_reproductive_system0.82971721
101MP0002090_abnormal_vision0.81811831
102MP0004147_increased_porphyrin_level0.81762921
103MP0005310_abnormal_salivary_gland0.81555077
104MP0004142_abnormal_muscle_tone0.80279049
105MP0005365_abnormal_bile_salt0.79920238
106MP0005248_abnormal_Harderian_gland0.79624292
107MP0001970_abnormal_pain_threshold0.79231584
108MP0005367_renal/urinary_system_phenotyp0.79073782
109MP0000516_abnormal_urinary_system0.79073782
110MP0002139_abnormal_hepatobiliary_system0.79056259
111MP0005423_abnormal_somatic_nervous0.78789914
112MP0008775_abnormal_heart_ventricle0.77820560
113MP0001485_abnormal_pinna_reflex0.77367273
114MP0008789_abnormal_olfactory_epithelium0.76792394
115MP0002118_abnormal_lipid_homeostasis0.76383210
116MP0005075_abnormal_melanosome_morpholog0.75877793
117MP0003252_abnormal_bile_duct0.74036583
118MP0000955_abnormal_spinal_cord0.71251330
119MP0002751_abnormal_autonomic_nervous0.70297368
120MP0002063_abnormal_learning/memory/cond0.70194806
121MP0000230_abnormal_systemic_arterial0.69486321
122MP0005375_adipose_tissue_phenotype0.69255109
123MP0000639_abnormal_adrenal_gland0.67845190
124MP0002069_abnormal_eating/drinking_beha0.66700359
125MP0006054_spinal_hemorrhage0.65643672
126MP0005187_abnormal_penis_morphology0.65626861
127MP0001501_abnormal_sleep_pattern0.64141357
128MP0002938_white_spotting0.64092519
129MP0002229_neurodegeneration0.63252413
130MP0005084_abnormal_gallbladder_morpholo0.60779329
131MP0006292_abnormal_olfactory_placode0.60388617
132MP0003300_gastrointestinal_ulcer0.59826228
133MP0002177_abnormal_outer_ear0.58833491
134MP0004811_abnormal_neuron_physiology0.57606735
135MP0005499_abnormal_olfactory_system0.57297353
136MP0005394_taste/olfaction_phenotype0.57297353
137MP0002067_abnormal_sensory_capabilities0.57164772
138MP0001188_hyperpigmentation0.57003679
139MP0002064_seizures0.55921169
140MP0004145_abnormal_muscle_electrophysio0.55180961
141MP0004085_abnormal_heartbeat0.54840303
142MP0003634_abnormal_glial_cell0.53960253
143MP0002735_abnormal_chemical_nociception0.53422162
144MP0009703_decreased_birth_body0.52404847

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.27383302
2Hypoglycemic seizures (HP:0002173)6.81757752
3Symptomatic seizures (HP:0011145)6.45074763
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.09649381
5Hypoglycemic coma (HP:0001325)5.45383158
6Insulin-resistant diabetes mellitus (HP:0000831)4.86072249
7Hyperglycemia (HP:0003074)4.33087689
8Decreased circulating renin level (HP:0003351)4.27622953
9Pancreatic islet-cell hyperplasia (HP:0004510)4.12446190
10Abnormality of calcium-phosphate metabolism (HP:0100530)4.06317787
11Abnormality of endocrine pancreas physiology (HP:0012093)3.92782792
12Abnormality of the pancreatic islet cells (HP:0006476)3.92782792
13Abnormal pancreas size (HP:0012094)3.91985253
14Large for gestational age (HP:0001520)3.79677934
15Ketoacidosis (HP:0001993)3.72865365
16Hypothermia (HP:0002045)3.68343730
17Late onset (HP:0003584)3.50643807
18Enlarged penis (HP:0000040)3.25030138
19Agitation (HP:0000713)3.23954356
20Hypokalemia (HP:0002900)3.22547788
21Dysostosis multiplex (HP:0000943)3.19088894
22Generalized aminoaciduria (HP:0002909)3.17341677
23Hemiparesis (HP:0001269)3.09242993
24Osteomalacia (HP:0002749)3.00266235
25Progressive macrocephaly (HP:0004481)2.92551052
26Chronic bronchitis (HP:0004469)2.89237083
27Abnormality of vitamin B metabolism (HP:0004340)2.84709549
28Hypomagnesemia (HP:0002917)2.79207707
29Abnormality of the intrinsic pathway (HP:0010989)2.76531826
30Hyperthyroidism (HP:0000836)2.75823708
31Urinary glycosaminoglycan excretion (HP:0003541)2.75303577
32Mucopolysacchariduria (HP:0008155)2.75303577
33Nephronophthisis (HP:0000090)2.74303229
34Gaze-evoked nystagmus (HP:0000640)2.73199694
35Urethral obstruction (HP:0000796)2.68961534
36Abnormality of renin-angiotensin system (HP:0000847)2.67999354
37EEG with generalized epileptiform discharges (HP:0011198)2.67909315
38Conjugated hyperbilirubinemia (HP:0002908)2.66589005
39Cortical visual impairment (HP:0100704)2.66304430
40Hamartoma of the eye (HP:0010568)2.63658751
41Hypsarrhythmia (HP:0002521)2.63469261
42Insulin resistance (HP:0000855)2.61037642
43Abnormality of polysaccharide metabolism (HP:0011012)2.60830488
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60830488
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60830488
46Retinal atrophy (HP:0001105)2.58470130
47Conjunctival hamartoma (HP:0100780)2.58009663
48Epileptiform EEG discharges (HP:0011182)2.57785279
49Hypoplasia of the fovea (HP:0007750)2.57681484
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.57681484
51Intestinal atresia (HP:0011100)2.55359563
52Visual hallucinations (HP:0002367)2.54435803
53Hyperactive renin-angiotensin system (HP:0000841)2.53728458
54Abnormality of potassium homeostasis (HP:0011042)2.53720403
55Abnormality of the fovea (HP:0000493)2.52599810
56Pheochromocytoma (HP:0002666)2.48616827
57Methylmalonic acidemia (HP:0002912)2.46598963
58Unilateral renal agenesis (HP:0000122)2.45760433
59Hematochezia (HP:0002573)2.44695723
60Abnormal drinking behavior (HP:0030082)2.44265665
61Polydipsia (HP:0001959)2.44265665
62Neoplasm of the adrenal cortex (HP:0100641)2.43411145
63Dysautonomia (HP:0002459)2.40475174
64Gout (HP:0001997)2.40197977
65Abnormality of the renal cortex (HP:0011035)2.38557782
66Bifid tongue (HP:0010297)2.38367000
67Medial flaring of the eyebrow (HP:0010747)2.38022291
68Acute necrotizing encephalopathy (HP:0006965)2.36682370
69Hyperkalemia (HP:0002153)2.36300425
70Abnormality of vitamin metabolism (HP:0100508)2.35847058
71Hyperparathyroidism (HP:0000843)2.35537002
72Neuroendocrine neoplasm (HP:0100634)2.31105282
73Hyperventilation (HP:0002883)2.27985873
74Furrowed tongue (HP:0000221)2.27972411
75Hypoalbuminemia (HP:0003073)2.24262363
76Abnormal albumin level (HP:0012116)2.24262363
77Limb hypertonia (HP:0002509)2.23083898
78Abnormality of the renal medulla (HP:0100957)2.22199937
79Gait imbalance (HP:0002141)2.20586492
80Increased CSF protein (HP:0002922)2.19886293
81Abnormality of urine glucose concentration (HP:0011016)2.18613915
82Glycosuria (HP:0003076)2.18613915
83Double outlet right ventricle (HP:0001719)2.17971017
84Congenital malformation of the right heart (HP:0011723)2.17971017
85Cystic liver disease (HP:0006706)2.15340662
86Testicular neoplasm (HP:0010788)2.15225508
87Mitochondrial inheritance (HP:0001427)2.14610911
88Congenital primary aphakia (HP:0007707)2.13222972
89Hepatic necrosis (HP:0002605)2.12680759
90Abnormality of midbrain morphology (HP:0002418)2.12599434
91Molar tooth sign on MRI (HP:0002419)2.12599434
92Pancreatic fibrosis (HP:0100732)2.12189919
93Menstrual irregularities (HP:0000858)2.11617654
94Dialeptic seizures (HP:0011146)2.10694569
95Prominent metopic ridge (HP:0005487)2.10390141
96Tubular atrophy (HP:0000092)2.07578121
97Attenuation of retinal blood vessels (HP:0007843)2.05221038
98Exocrine pancreatic insufficiency (HP:0001738)2.04885511
99Increased circulating renin level (HP:0000848)2.04404150
100Abnormal rod and cone electroretinograms (HP:0008323)2.02977616
101Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02924626
102Abnormal protein glycosylation (HP:0012346)2.01262052
103Abnormal glycosylation (HP:0012345)2.01262052
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01262052
105Abnormal protein N-linked glycosylation (HP:0012347)2.01262052
106Increased CSF lactate (HP:0002490)2.01138965
107Abnormality of liposaccharide metabolism (HP:0010968)2.00810363
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.00810363
109Abnormality of glycolipid metabolism (HP:0010969)2.00810363
110Abnormality of magnesium homeostasis (HP:0004921)1.99883057
111Neoplasm of the adrenal gland (HP:0100631)1.99512055
112Methylmalonic aciduria (HP:0012120)1.99377074
113Poor suck (HP:0002033)1.98944901
114Delayed gross motor development (HP:0002194)1.98603764
115Progressive inability to walk (HP:0002505)1.97758050
116Atonic seizures (HP:0010819)1.97171895
117Tubulointerstitial nephritis (HP:0001970)1.96911314
118Oligomenorrhea (HP:0000876)1.96278871
119Vacuolated lymphocytes (HP:0001922)1.95729295
120Nephrogenic diabetes insipidus (HP:0009806)1.95721655
121Bony spicule pigmentary retinopathy (HP:0007737)1.94696458
122Metaphyseal dysplasia (HP:0100255)1.94380819
123Ketosis (HP:0001946)1.93661348
124Anxiety (HP:0000739)1.92279055
125Restlessness (HP:0000711)1.91844204
126Syncope (HP:0001279)1.91063018
127Progressive neurologic deterioration (HP:0002344)1.89478228
128Polyphagia (HP:0002591)1.88984109
129Tongue fasciculations (HP:0001308)1.88479162
130Acute encephalopathy (HP:0006846)1.88310675
131Renal Fanconi syndrome (HP:0001994)1.86297385
132Aqueductal stenosis (HP:0002410)1.86111953
133Congenital sensorineural hearing impairment (HP:0008527)1.85982956
134Abdominal distention (HP:0003270)1.85644137
135Polyuria (HP:0000103)1.85061551
136Hypotension (HP:0002615)1.84430265
137Abnormal mitochondria in muscle tissue (HP:0008316)1.83808997
138Thoracolumbar scoliosis (HP:0002944)1.83670273
139Papilledema (HP:0001085)1.83636740
140Papillary thyroid carcinoma (HP:0002895)1.83462377
141Irregular vertebral endplates (HP:0003301)1.83223580
142Absent eyebrow (HP:0002223)1.83134513
143Abnormality of the metopic suture (HP:0005556)1.82354062
144Generalized tonic-clonic seizures (HP:0002069)1.82208157
145Increased hepatocellular lipid droplets (HP:0006565)1.82026234
146Retinal dysplasia (HP:0007973)1.81513401
147Failure to thrive in infancy (HP:0001531)1.81104710
148Macroorchidism (HP:0000053)1.80128761
149Hepatocellular necrosis (HP:0001404)1.77985399
150Renal cortical cysts (HP:0000803)1.77697816
151Congenital glaucoma (HP:0001087)1.75649759
152Abnormality of chloride homeostasis (HP:0011422)1.75219054
153Glucose intolerance (HP:0000833)1.74696904
154Type II lissencephaly (HP:0007260)1.74096868
155Congenital stationary night blindness (HP:0007642)1.73961425
156Hypercortisolism (HP:0001578)1.73568957
157True hermaphroditism (HP:0010459)1.71706084
158Hypophosphatemia (HP:0002148)1.69284754
159Pancreatic cysts (HP:0001737)1.67531377
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66706841
161Type II diabetes mellitus (HP:0005978)1.66593207
162Muscular hypotonia of the trunk (HP:0008936)1.65251007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.58584324
2PASK5.31036221
3MAPK154.68838700
4FGFR23.70851113
5PRKD33.42033736
6MST43.38530203
7MAP4K23.35581965
8HIPK22.96270981
9TAOK32.87600830
10MAP3K22.83271928
11FRK2.72325229
12WNK32.31700711
13DAPK22.11679968
14NTRK32.02626356
15GRK11.95889197
16ADRBK21.87895218
17WNK41.84868098
18AKT31.78225509
19CAMKK21.77733434
20ERBB31.73028324
21UHMK11.71770184
22FGFR31.70434398
23CSNK1G11.65337377
24CDC42BPA1.64955909
25ACVR1B1.64951128
26NTRK11.62111565
27IRAK31.56346939
28CSNK1G31.41501905
29MAP3K41.39292391
30IRAK11.29354240
31STK31.29237090
32FLT31.27582938
33BMPR21.17033080
34PINK11.14290841
35BMPR1B1.13979936
36PAK31.13688143
37OXSR11.13471528
38MAP2K61.13288856
39SCYL21.10579049
40PRKCH1.09413847
41MAP3K121.08457918
42MAP2K71.07117755
43PTK2B1.05864892
44STK38L1.04571994
45IRAK20.99322009
46BRAF0.96020198
47PRKCE0.95506975
48PIK3CG0.93970568
49MARK10.92956042
50BRD40.92648721
51PDGFRA0.92165098
52MAP3K10.91295466
53TRPM70.89854097
54STK390.87969111
55MAPK130.87662576
56PRKD20.85589540
57DYRK1B0.84877407
58EPHA30.80226007
59MKNK20.79062734
60MAP3K90.77630462
61PLK20.77341203
62CASK0.76424410
63PNCK0.75414268
64BRSK20.75025404
65SGK20.72931709
66EIF2AK30.72584107
67SGK2230.72531774
68SGK4940.72531774
69PTK60.71572061
70STK40.71477273
71CAMK2D0.69806795
72STK110.69665476
73TNK20.68694927
74FER0.68476299
75PTK20.65832312
76CAMK2B0.64191510
77RPS6KA20.62172019
78PRKCI0.57796262
79LIMK10.57268085
80PRKAA10.57171837
81CDK50.56977441
82DYRK1A0.56170141
83WNK10.55441743
84VRK10.53879214
85RPS6KB10.53136701
86PRKCG0.53054498
87PRKG10.51782349
88STK160.50888825
89ADRBK10.49446169
90MARK20.48981610
91PRKAA20.48574132
92CSNK1A1L0.47966775
93MAP2K20.47305917
94CDK80.45700455
95ERBB40.42597079
96STK240.42195094
97MAP2K40.41478869
98ERN10.41276366
99TNIK0.40775032
100ZAK0.40730519
101NEK60.40493693
102GRK50.39535338
103PRKACA0.39529107
104YES10.38797549
105ITK0.38713951
106ROCK10.38524536
107CSNK1A10.38153602
108TAF10.37991680
109NUAK10.37389635
110CSNK1D0.36927070
111PLK30.36826390
112SGK30.36771210
113CAMKK10.35519128
114DYRK30.35509603
115PRKACG0.35381011
116RET0.35180698
117TIE10.35133359
118PRKACB0.33915563
119BCR0.32043210
120DYRK20.32007508
121JAK20.31594509
122STK380.31353038
123TAOK10.31198804
124SIK10.30119698
125SGK10.30048176
126PRKCZ0.29934935
127ROCK20.29370595
128IGF1R0.28951546
129NTRK20.28683220
130IRAK40.28098123
131NME10.28055995
132PRKG20.27753600
133GSK3A0.26397583
134PRKDC0.26339732
135CDK30.26245313
136CSNK1G20.26224522
137CAMK2A0.25547944
138CSNK1E0.25466398
139DAPK10.24872439
140MAPK140.23674658
141PRKD10.23603047
142PRKCA0.23200135
143PHKG20.22894457
144PHKG10.22894457
145EPHB10.22873163
146MAP3K30.22626510
147BRSK10.22203457
148MET0.22007326
149CAMK10.21783754
150NLK0.21651468
151RPS6KA50.20473906

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.27134168
2Protein export_Homo sapiens_hsa030605.61692832
3* Insulin secretion_Homo sapiens_hsa049113.16633959
4Sulfur metabolism_Homo sapiens_hsa009203.16424395
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.82489157
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.75899192
7Vibrio cholerae infection_Homo sapiens_hsa051102.51754120
8Vitamin B6 metabolism_Homo sapiens_hsa007502.19474411
9Type II diabetes mellitus_Homo sapiens_hsa049302.13081776
10Type I diabetes mellitus_Homo sapiens_hsa049402.08081060
11Cocaine addiction_Homo sapiens_hsa050301.80060849
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.80059942
13Taste transduction_Homo sapiens_hsa047421.77013371
14Collecting duct acid secretion_Homo sapiens_hsa049661.67584134
15N-Glycan biosynthesis_Homo sapiens_hsa005101.62695896
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62297052
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60545216
18Amphetamine addiction_Homo sapiens_hsa050311.53702357
19Synaptic vesicle cycle_Homo sapiens_hsa047211.44739739
20Circadian rhythm_Homo sapiens_hsa047101.42863451
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41429022
22Regulation of autophagy_Homo sapiens_hsa041401.39405395
23Ether lipid metabolism_Homo sapiens_hsa005651.38534234
24Other glycan degradation_Homo sapiens_hsa005111.35679638
25Olfactory transduction_Homo sapiens_hsa047401.33745655
26Propanoate metabolism_Homo sapiens_hsa006401.29388992
27Lysosome_Homo sapiens_hsa041421.27469861
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27142286
29GABAergic synapse_Homo sapiens_hsa047271.24974376
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22108435
31Dopaminergic synapse_Homo sapiens_hsa047281.20286836
32Selenocompound metabolism_Homo sapiens_hsa004501.15273890
33Glucagon signaling pathway_Homo sapiens_hsa049221.11941280
34Cardiac muscle contraction_Homo sapiens_hsa042601.11764241
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.10379817
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07905970
37Circadian entrainment_Homo sapiens_hsa047131.07046849
38Thyroid hormone synthesis_Homo sapiens_hsa049181.07002945
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05745949
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02207675
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01313675
42Serotonergic synapse_Homo sapiens_hsa047261.00902401
43beta-Alanine metabolism_Homo sapiens_hsa004100.99794419
44Fatty acid elongation_Homo sapiens_hsa000620.98602567
45Long-term potentiation_Homo sapiens_hsa047200.98572674
46Cholinergic synapse_Homo sapiens_hsa047250.97553247
47Peroxisome_Homo sapiens_hsa041460.97505671
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96012530
49Morphine addiction_Homo sapiens_hsa050320.95388185
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94578062
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91358726
52Mineral absorption_Homo sapiens_hsa049780.89242895
53Pancreatic secretion_Homo sapiens_hsa049720.86963527
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82046135
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81072415
56Butanoate metabolism_Homo sapiens_hsa006500.80088886
57Insulin resistance_Homo sapiens_hsa049310.79298322
58Prolactin signaling pathway_Homo sapiens_hsa049170.78150719
59Alcoholism_Homo sapiens_hsa050340.77963074
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77173745
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75276589
62Nitrogen metabolism_Homo sapiens_hsa009100.73951331
63Sphingolipid metabolism_Homo sapiens_hsa006000.73472238
64Estrogen signaling pathway_Homo sapiens_hsa049150.71475975
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71364388
66Fatty acid metabolism_Homo sapiens_hsa012120.71060263
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70714308
68Arginine biosynthesis_Homo sapiens_hsa002200.69070712
69Prion diseases_Homo sapiens_hsa050200.69023815
70ABC transporters_Homo sapiens_hsa020100.67726781
71Galactose metabolism_Homo sapiens_hsa000520.67723498
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.66128731
73Retinol metabolism_Homo sapiens_hsa008300.63273265
74Glutamatergic synapse_Homo sapiens_hsa047240.61880180
75Oxidative phosphorylation_Homo sapiens_hsa001900.61788522
76Caffeine metabolism_Homo sapiens_hsa002320.58649545
77Renin secretion_Homo sapiens_hsa049240.58521352
78Metabolic pathways_Homo sapiens_hsa011000.55910615
79Fatty acid degradation_Homo sapiens_hsa000710.54373373
80Basal transcription factors_Homo sapiens_hsa030220.54320538
81Insulin signaling pathway_Homo sapiens_hsa049100.51626120
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50251068
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48861489
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47713086
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.47134400
86cAMP signaling pathway_Homo sapiens_hsa040240.46828292
87Chemical carcinogenesis_Homo sapiens_hsa052040.46329276
88* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46296092
89Tryptophan metabolism_Homo sapiens_hsa003800.45580104
90Alzheimers disease_Homo sapiens_hsa050100.45437324
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45190012
92Calcium signaling pathway_Homo sapiens_hsa040200.44289880
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44182002
94Nicotine addiction_Homo sapiens_hsa050330.44071511
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43939959
96Folate biosynthesis_Homo sapiens_hsa007900.43295679
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43225887
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.43204939
99Ovarian steroidogenesis_Homo sapiens_hsa049130.42514167
100Phagosome_Homo sapiens_hsa041450.42450002
101Phenylalanine metabolism_Homo sapiens_hsa003600.41782253
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40175113
103Dorso-ventral axis formation_Homo sapiens_hsa043200.38489409
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37196145
105Arachidonic acid metabolism_Homo sapiens_hsa005900.36252670
106Inositol phosphate metabolism_Homo sapiens_hsa005620.36141255
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35941607
108* Vascular smooth muscle contraction_Homo sapiens_hsa042700.35575989
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35299577
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34523306
111Gastric acid secretion_Homo sapiens_hsa049710.33821491
112Starch and sucrose metabolism_Homo sapiens_hsa005000.31308485
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29673458
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29603897
115GnRH signaling pathway_Homo sapiens_hsa049120.29092083
116Melanogenesis_Homo sapiens_hsa049160.28790896
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28697286
118Long-term depression_Homo sapiens_hsa047300.25455177
119AMPK signaling pathway_Homo sapiens_hsa041520.25066833
120Linoleic acid metabolism_Homo sapiens_hsa005910.24713819
121FoxO signaling pathway_Homo sapiens_hsa040680.24408802
122mTOR signaling pathway_Homo sapiens_hsa041500.24247860
123Parkinsons disease_Homo sapiens_hsa050120.24202229
124Histidine metabolism_Homo sapiens_hsa003400.23057739
125Gap junction_Homo sapiens_hsa045400.23012302
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22998171
127Prostate cancer_Homo sapiens_hsa052150.22872198
128Phototransduction_Homo sapiens_hsa047440.22822042
129Rheumatoid arthritis_Homo sapiens_hsa053230.22339759
130Salivary secretion_Homo sapiens_hsa049700.21224646
131Huntingtons disease_Homo sapiens_hsa050160.20231293
132Tyrosine metabolism_Homo sapiens_hsa003500.19081547
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17281464

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