KCNMB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host cellular process (GO:0044068)9.10772977
2cellular response to virus (GO:0098586)7.94627609
3negative regulation of catenin import into nucleus (GO:0035414)7.49160690
4negative regulation of execution phase of apoptosis (GO:1900118)7.30701633
5calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.96884702
6sensory perception of smell (GO:0007608)6.96634252
7pericardium development (GO:0060039)6.62306327
8morphogenesis of an endothelium (GO:0003159)6.20023945
9endothelial tube morphogenesis (GO:0061154)6.20023945
10regulation of telomere maintenance via telomerase (GO:0032210)6.15577586
11venous blood vessel morphogenesis (GO:0048845)6.02940910
12sensory perception of chemical stimulus (GO:0007606)5.85509505
13modulation by virus of host morphology or physiology (GO:0019048)5.78554140
14negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.70849386
15adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.59631949
16protein localization to cilium (GO:0061512)5.34463515
17negative regulation of telomere maintenance (GO:0032205)5.29927272
18ADP metabolic process (GO:0046031)5.12996589
19metallo-sulfur cluster assembly (GO:0031163)5.09144842
20iron-sulfur cluster assembly (GO:0016226)5.09144842
21negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.93020833
22cellular response to prostaglandin stimulus (GO:0071379)4.86372771
23sensory perception of taste (GO:0050909)4.84202821
24cellular response to glucagon stimulus (GO:0071377)4.82968157
25cellular response to gamma radiation (GO:0071480)4.75752182
26hepatocyte apoptotic process (GO:0097284)4.69546248
27regulation of female gonad development (GO:2000194)4.64307288
28negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.55477421
29behavioral response to nicotine (GO:0035095)4.32106104
30type B pancreatic cell proliferation (GO:0044342)4.25982378
31protein insertion into membrane (GO:0051205)4.25411034
32negative regulation of establishment of protein localization to plasma membrane (GO:0090005)4.22236834
33regulation of G0 to G1 transition (GO:0070316)4.19043294
34valine metabolic process (GO:0006573)4.15224489
35regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.14464129
36regulation of protein targeting to membrane (GO:0090313)4.10395956
37glutathione biosynthetic process (GO:0006750)4.05289986
38regulation of nuclear cell cycle DNA replication (GO:0033262)4.00886989
39nerve growth factor signaling pathway (GO:0038180)3.98140051
40microtubule bundle formation (GO:0001578)3.96946300
41nonribosomal peptide biosynthetic process (GO:0019184)3.76458211
42glycerophospholipid catabolic process (GO:0046475)3.74132618
43release of cytochrome c from mitochondria (GO:0001836)3.73938899
44regulation of glucokinase activity (GO:0033131)3.67083827
45regulation of hexokinase activity (GO:1903299)3.67083827
46response to glucagon (GO:0033762)3.65014834
47detection of light stimulus involved in sensory perception (GO:0050962)3.63701371
48detection of light stimulus involved in visual perception (GO:0050908)3.63701371
49cellular response to nicotine (GO:0071316)3.63001449
50endothelial cell development (GO:0001885)3.62833454
51regulation of telomerase activity (GO:0051972)3.61463227
52regulation of cilium movement (GO:0003352)3.57465994
53response to pheromone (GO:0019236)3.56131355
54positive regulation of protein targeting to membrane (GO:0090314)3.54484063
55modification by symbiont of host morphology or physiology (GO:0044003)3.52675446
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.50079937
57cysteine metabolic process (GO:0006534)3.47959922
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46488928
59proline biosynthetic process (GO:0006561)3.46050783
60Rap protein signal transduction (GO:0032486)3.44484274
61snRNA transcription (GO:0009301)3.44026265
62L-fucose catabolic process (GO:0042355)3.43905613
63fucose catabolic process (GO:0019317)3.43905613
64L-fucose metabolic process (GO:0042354)3.43905613
65negative regulation of Ras GTPase activity (GO:0034261)3.43724487
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.40667415
67negative regulation of DNA-templated transcription, elongation (GO:0032785)3.40667415
68purine nucleoside diphosphate metabolic process (GO:0009135)3.39618864
69purine ribonucleoside diphosphate metabolic process (GO:0009179)3.39618864
70negative regulation of anoikis (GO:2000811)3.39010689
71cellular ketone body metabolic process (GO:0046950)3.38712293
72protein-cofactor linkage (GO:0018065)3.36890380
73neurofilament cytoskeleton organization (GO:0060052)3.34670687
74replication fork processing (GO:0031297)3.34086344
75mannosylation (GO:0097502)3.33042528
76embryonic camera-type eye development (GO:0031076)3.27148666
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.24948312
78positive regulation of DNA biosynthetic process (GO:2000573)3.23474166
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.19147389
80bone trabecula formation (GO:0060346)3.18219844
81reciprocal DNA recombination (GO:0035825)3.17648688
82reciprocal meiotic recombination (GO:0007131)3.17648688
83centriole assembly (GO:0098534)3.17455034
84layer formation in cerebral cortex (GO:0021819)3.14287101
85positive regulation of hair follicle development (GO:0051798)3.11595392
86positive regulation of hair cycle (GO:0042635)3.11595392
87regulation of execution phase of apoptosis (GO:1900117)3.10423302
88natural killer cell mediated immunity (GO:0002228)3.09705601
89natural killer cell mediated cytotoxicity (GO:0042267)3.09705601
90preassembly of GPI anchor in ER membrane (GO:0016254)3.08589433
91regulation of synapse maturation (GO:0090128)3.07726736
92ketone body metabolic process (GO:1902224)3.07559945
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07182680
94response to auditory stimulus (GO:0010996)3.06851290
95negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06264713
96negative regulation of translation, ncRNA-mediated (GO:0040033)3.06264713
97regulation of translation, ncRNA-mediated (GO:0045974)3.06264713
98negative regulation of mast cell activation (GO:0033004)3.05826060
99synapsis (GO:0007129)3.05409051
100endothelial cell differentiation (GO:0045446)3.04681941
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03683916
102peptide biosynthetic process (GO:0043043)3.03028404
103positive regulation of synapse maturation (GO:0090129)3.02929237
104centriole replication (GO:0007099)3.01532702
105glycine transport (GO:0015816)3.01505813
106dopamine transport (GO:0015872)3.01158386
107negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.00918585
108piRNA metabolic process (GO:0034587)2.98757988
109amyloid precursor protein catabolic process (GO:0042987)2.97719639
110negative regulation of protein localization to plasma membrane (GO:1903077)2.96135341
111cilium or flagellum-dependent cell motility (GO:0001539)2.95507214
112hindbrain development (GO:0030902)2.95504820
113kidney morphogenesis (GO:0060993)2.94971973
114negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.94900749
115ovulation cycle (GO:0042698)2.94119930
116branched-chain amino acid catabolic process (GO:0009083)2.94079542
117DNA methylation involved in gamete generation (GO:0043046)2.93840923
118ribonucleoside diphosphate metabolic process (GO:0009185)2.93544774
119cytidine deamination (GO:0009972)2.92100740
120cytidine metabolic process (GO:0046087)2.92100740
121cytidine catabolic process (GO:0006216)2.92100740
122platelet dense granule organization (GO:0060155)2.90595403
123signal transduction in absence of ligand (GO:0038034)2.89484073
124extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.89484073
125neural tube formation (GO:0001841)2.89381673
126activation of MAPKKK activity (GO:0000185)2.88513704
127indolalkylamine metabolic process (GO:0006586)2.86847937
128I-kappaB phosphorylation (GO:0007252)2.85696697
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84357265
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.84357265
131NADH dehydrogenase complex assembly (GO:0010257)2.84357265
132kynurenine metabolic process (GO:0070189)2.84237650
133tryptophan catabolic process (GO:0006569)2.84072817
134indole-containing compound catabolic process (GO:0042436)2.84072817
135indolalkylamine catabolic process (GO:0046218)2.84072817
136negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.83702876
137regulation of action potential (GO:0098900)2.82362209
138regulation of telomere maintenance (GO:0032204)2.82296509
139regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81343296
140protein polyglutamylation (GO:0018095)2.80481889
141DNA deamination (GO:0045006)2.79723691
142epithelial cilium movement (GO:0003351)2.79453281
143nephron tubule morphogenesis (GO:0072078)2.79261135
144nephron epithelium morphogenesis (GO:0072088)2.79261135
145positive regulation of Rap GTPase activity (GO:0032854)2.78372848
146* neuronal action potential (GO:0019228)2.76132474
147cellular response to alkaloid (GO:0071312)2.75057670
148regulation of chromatin binding (GO:0035561)2.74314038
149intraciliary transport (GO:0042073)2.74173442
150male meiosis I (GO:0007141)2.73143889
151pyrimidine ribonucleoside catabolic process (GO:0046133)2.71466007
152mitochondrion morphogenesis (GO:0070584)2.71351897
153negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71048220
154respiratory chain complex IV assembly (GO:0008535)2.70937762
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70840858
156establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.70683487
157protein complex biogenesis (GO:0070271)2.70492386
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65857621
159water-soluble vitamin biosynthetic process (GO:0042364)2.63625157
160resolution of meiotic recombination intermediates (GO:0000712)2.60215378
161regulation of neurotransmitter uptake (GO:0051580)2.58085555
162cilium morphogenesis (GO:0060271)2.55576219
163recombinational repair (GO:0000725)2.51578543
164double-strand break repair via homologous recombination (GO:0000724)2.51117294
165branched-chain amino acid metabolic process (GO:0009081)2.49932023
166reflex (GO:0060004)2.49780405
167mitochondrial respiratory chain complex assembly (GO:0033108)2.49182265
168photoreceptor cell maintenance (GO:0045494)2.48845916
169rhodopsin mediated signaling pathway (GO:0016056)2.48797383
170gamma-aminobutyric acid transport (GO:0015812)2.48709882
171tryptophan metabolic process (GO:0006568)2.47464622
172male meiosis (GO:0007140)2.47070281
173sulfation (GO:0051923)2.46546729
174axoneme assembly (GO:0035082)2.46104578
175photoreceptor cell development (GO:0042461)2.45660853
176phosphatidylinositol acyl-chain remodeling (GO:0036149)2.45107112
177positive regulation of meiosis (GO:0045836)2.42511605
178regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42176616
179renal tubule morphogenesis (GO:0061333)2.42163255
180GPI anchor metabolic process (GO:0006505)2.41790580
181amine catabolic process (GO:0009310)2.40740006
182cellular biogenic amine catabolic process (GO:0042402)2.40740006
183protein K11-linked deubiquitination (GO:0035871)2.39481568
184negative regulation of DNA-dependent DNA replication (GO:2000104)2.37501195
185signal peptide processing (GO:0006465)2.36868149
186behavioral response to ethanol (GO:0048149)2.36742568
187L-methionine salvage (GO:0071267)2.34081472
188L-methionine biosynthetic process (GO:0071265)2.34081472
189amino acid salvage (GO:0043102)2.34081472
190protein neddylation (GO:0045116)2.33716084
191multicellular organism reproduction (GO:0032504)2.32008860
192single strand break repair (GO:0000012)2.31443645
193pseudouridine synthesis (GO:0001522)2.31410203
194indole-containing compound metabolic process (GO:0042430)2.30528467
195phosphorelay signal transduction system (GO:0000160)12.9356796
196modulation by virus of host process (GO:0019054)11.4288471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.46377144
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.38885178
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.76497462
4EZH2_22144423_ChIP-Seq_EOC_Human3.93172246
5ZNF274_21170338_ChIP-Seq_K562_Hela3.88661270
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.75822998
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.63910332
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.01441777
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85100935
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80620281
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43770853
12IGF1R_20145208_ChIP-Seq_DFB_Human2.43100712
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28039440
14EWS_26573619_Chip-Seq_HEK293_Human2.25699921
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20832865
16FUS_26573619_Chip-Seq_HEK293_Human2.19597628
17P300_19829295_ChIP-Seq_ESCs_Human2.05013355
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.00420782
19ER_23166858_ChIP-Seq_MCF-7_Human1.98735669
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97399187
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90769215
22GBX2_23144817_ChIP-Seq_PC3_Human1.87297918
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85327160
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.81696616
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.79148353
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77272749
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64736501
28BCAT_22108803_ChIP-Seq_LS180_Human1.64703971
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63264963
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63264963
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62451413
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59631293
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58918427
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57319151
35* STAT3_23295773_ChIP-Seq_U87_Human1.55737529
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55111519
37CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55038903
38AR_25329375_ChIP-Seq_VCAP_Human1.54317032
39DROSHA_22980978_ChIP-Seq_HELA_Human1.53737723
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52332358
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.52116957
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.50504418
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.48227695
44TP53_22573176_ChIP-Seq_HFKS_Human1.46853489
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45984530
46CBP_20019798_ChIP-Seq_JUKART_Human1.45984530
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44810296
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.42410637
49TCF4_23295773_ChIP-Seq_U87_Human1.42277400
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.42249295
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42000879
52AHR_22903824_ChIP-Seq_MCF-7_Human1.41069556
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40610779
54MYC_18940864_ChIP-ChIP_HL60_Human1.38683336
55NANOG_19829295_ChIP-Seq_ESCs_Human1.37970790
56SOX2_19829295_ChIP-Seq_ESCs_Human1.37970790
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36403169
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.36065856
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35746403
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35454485
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35046548
62AR_21572438_ChIP-Seq_LNCaP_Human1.34064663
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32865795
64RNF2_27304074_Chip-Seq_NSC_Mouse1.31693204
65KDM2B_26808549_Chip-Seq_K562_Human1.31686991
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.30570110
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.30364379
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30004171
69TCF4_22108803_ChIP-Seq_LS180_Human1.29684782
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27656409
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27387089
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.27235626
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26457374
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26266680
75IRF1_19129219_ChIP-ChIP_H3396_Human1.25813802
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25129005
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25129005
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24671553
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.24260451
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23791706
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.23588699
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22530246
83REST_21632747_ChIP-Seq_MESCs_Mouse1.22488780
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22014181
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21737659
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18777464
87TP53_18474530_ChIP-ChIP_U2OS_Human1.17497554
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16644197
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.16644197
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16176231
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.16101433
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.15724431
93NCOR_22424771_ChIP-Seq_293T_Human1.15331041
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14781939
95P300_18555785_Chip-Seq_ESCs_Mouse1.13857201
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13746729
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13667513
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13594985
99JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13491623
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12817101
101ELK1_19687146_ChIP-ChIP_HELA_Human1.12755461
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.12236108
103* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12071247
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.11548010
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.10974739
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.09982210
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09871339
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09694833
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09412189
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09293930
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09086491
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09005778
113KDM2B_26808549_Chip-Seq_REH_Human1.08649409
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07151108
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.06390988
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.05561933
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05504379
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05393541
119GATA3_21867929_ChIP-Seq_TH1_Mouse1.04602786
120EZH2_27304074_Chip-Seq_ESCs_Mouse1.04492373
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04184227
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.03193372
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02909788
124SALL1_21062744_ChIP-ChIP_HESCs_Human1.02875907
125FOXH1_21741376_ChIP-Seq_EPCs_Human1.02713467
126ZFX_18555785_Chip-Seq_ESCs_Mouse1.02278705
127SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02227475
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.00651280
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00203752
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.99738847
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99213594
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.98346591
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97726770
134OCT4_18555785_Chip-Seq_ESCs_Mouse0.97616700
135TAF15_26573619_Chip-Seq_HEK293_Human0.97251726
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96899734
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96872295
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96754851
139* SMAD4_21799915_ChIP-Seq_A2780_Human0.96448426
140ETV1_20927104_ChIP-Seq_GIST48_Human0.96189856
141* HOXB7_26014856_ChIP-Seq_BT474_Human0.95947863
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.95691349
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.95534024
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95505394
145SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95332080
146ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94486772
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94166342
148P53_22387025_ChIP-Seq_ESCs_Mouse0.93171855
149RUNX2_22187159_ChIP-Seq_PCA_Human0.91733339
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.91348446
151KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91022796
152REST_18959480_ChIP-ChIP_MESCs_Mouse0.90254815
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.89914550
154KLF4_18555785_Chip-Seq_ESCs_Mouse0.89619811
155WT1_19549856_ChIP-ChIP_CCG9911_Human0.89016975
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.88879458
157CTCF_27219007_Chip-Seq_Bcells_Human0.88047311
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87839192
159STAT1_17558387_ChIP-Seq_HELA_Human0.87444571
160SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87273715
161GF1_26923725_Chip-Seq_HPCs_Mouse0.84927035
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83343606
163VDR_22108803_ChIP-Seq_LS180_Human0.82712744
164E2F1_20622854_ChIP-Seq_HELA_Human0.82673869
165FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82128607
166* CDX2_22108803_ChIP-Seq_LS180_Human0.82089902
167ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81990699
168CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80880665
169SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80764542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction7.76153599
2MP0005377_hearing/vestibular/ear_phenot6.39514909
3MP0003878_abnormal_ear_physiology6.39514909
4MP0004858_abnormal_nervous_system3.71741882
5MP0002102_abnormal_ear_morphology3.54617055
6MP0008877_abnormal_DNA_methylation3.30677169
7MP0005645_abnormal_hypothalamus_physiol3.18388101
8MP0000015_abnormal_ear_pigmentation3.06259544
9MP0001485_abnormal_pinna_reflex3.01171544
10MP0006292_abnormal_olfactory_placode2.93783583
11MP0003787_abnormal_imprinting2.56322615
12MP0005646_abnormal_pituitary_gland2.39027449
13MP0005451_abnormal_body_composition2.33887942
14MP0001986_abnormal_taste_sensitivity2.33756227
15MP0005623_abnormal_meninges_morphology2.26350497
16MP0008789_abnormal_olfactory_epithelium2.24122019
17MP0010352_gastrointestinal_tract_polyps2.22275739
18MP0002876_abnormal_thyroid_physiology2.19746723
19MP0008260_abnormal_autophagy2.06014933
20MP0008872_abnormal_physiological_respon2.02534464
21MP0009046_muscle_twitch1.98966101
22MP0002160_abnormal_reproductive_system1.98867595
23MP0005499_abnormal_olfactory_system1.95579022
24MP0005394_taste/olfaction_phenotype1.95579022
25MP0003646_muscle_fatigue1.94094590
26MP0005171_absent_coat_pigmentation1.91680023
27MP0008058_abnormal_DNA_repair1.91306528
28MP0002837_dystrophic_cardiac_calcinosis1.88773499
29MP0004142_abnormal_muscle_tone1.87261313
30MP0005084_abnormal_gallbladder_morpholo1.84592455
31MP0002653_abnormal_ependyma_morphology1.81302034
32MP0003890_abnormal_embryonic-extraembry1.80534206
33MP0003806_abnormal_nucleotide_metabolis1.77611688
34MP0003136_yellow_coat_color1.74523817
35MP0001346_abnormal_lacrimal_gland1.72894347
36MP0000579_abnormal_nail_morphology1.68051406
37MP0001188_hyperpigmentation1.66610955
38MP0002163_abnormal_gland_morphology1.66114527
39MP0005253_abnormal_eye_physiology1.65143026
40MP0008875_abnormal_xenobiotic_pharmacok1.63744536
41MP0006276_abnormal_autonomic_nervous1.62682995
42MP0009745_abnormal_behavioral_response1.60124679
43MP0002928_abnormal_bile_duct1.57855412
44MP0003718_maternal_effect1.57680323
45MP0003693_abnormal_embryo_hatching1.57504186
46MP0005174_abnormal_tail_pigmentation1.57477586
47MP0003011_delayed_dark_adaptation1.54718144
48MP0001486_abnormal_startle_reflex1.53901834
49MP0005410_abnormal_fertilization1.53870185
50MP0002127_abnormal_cardiovascular_syste1.48943111
51MP0003950_abnormal_plasma_membrane1.46778627
52MP0002735_abnormal_chemical_nociception1.45862356
53MP0004782_abnormal_surfactant_physiolog1.41802983
54MP0000372_irregular_coat_pigmentation1.40607770
55MP0005389_reproductive_system_phenotype1.40377278
56MP0001905_abnormal_dopamine_level1.37675214
57MP0000569_abnormal_digit_pigmentation1.36997560
58MP0000026_abnormal_inner_ear1.36967010
59MP0005408_hypopigmentation1.35327636
60MP0001963_abnormal_hearing_physiology1.32616910
61MP0003880_abnormal_central_pattern1.32590767
62MP0003121_genomic_imprinting1.32525665
63MP0000003_abnormal_adipose_tissue1.32154306
64MP0002095_abnormal_skin_pigmentation1.30449035
65MP0004270_analgesia1.30098877
66MP0004043_abnormal_pH_regulation1.30066980
67MP0008995_early_reproductive_senescence1.29202011
68MP0002098_abnormal_vibrissa_morphology1.28711596
69MP0004147_increased_porphyrin_level1.27367611
70MP0004742_abnormal_vestibular_system1.23076564
71MP0003195_calcinosis1.22789078
72MP0005423_abnormal_somatic_nervous1.22663687
73MP0004134_abnormal_chest_morphology1.22531865
74MP0005386_behavior/neurological_phenoty1.22098635
75MP0004924_abnormal_behavior1.22098635
76MP0000467_abnormal_esophagus_morphology1.21852863
77MP0001501_abnormal_sleep_pattern1.20239592
78MP0002733_abnormal_thermal_nociception1.17041253
79MP0003453_abnormal_keratinocyte_physiol1.12564838
80MP0001970_abnormal_pain_threshold1.11882816
81MP0003045_fibrosis1.10747638
82MP0001186_pigmentation_phenotype1.10472570
83MP0001119_abnormal_female_reproductive1.10083424
84MP0005379_endocrine/exocrine_gland_phen1.10049717
85MP0010386_abnormal_urinary_bladder1.08527165
86MP0004145_abnormal_muscle_electrophysio1.07464099
87MP0002064_seizures1.03889306
88MP0005085_abnormal_gallbladder_physiolo1.03405433
89MP0003566_abnormal_cell_adhesion1.02619206
90MP0003315_abnormal_perineum_morphology1.02216094
91MP0002067_abnormal_sensory_capabilities1.02156050
92MP0000613_abnormal_salivary_gland1.01568205
93MP0002938_white_spotting1.00775675
94MP0002184_abnormal_innervation0.99960098
95MP0001929_abnormal_gametogenesis0.99808778
96MP0004381_abnormal_hair_follicle0.99356324
97MP0003941_abnormal_skin_development0.98852966
98MP0002752_abnormal_somatic_nervous0.96609961
99MP0004859_abnormal_synaptic_plasticity0.95757991
100MP0003763_abnormal_thymus_physiology0.93580158
101MP0004133_heterotaxia0.93555205
102MP0005395_other_phenotype0.91997223
103MP0002277_abnormal_respiratory_mucosa0.91960923
104MP0003122_maternal_imprinting0.91745638
105MP0005671_abnormal_response_to0.91483066
106MP0002557_abnormal_social/conspecific_i0.90442099
107MP0001440_abnormal_grooming_behavior0.89993953
108MP0001324_abnormal_eye_pigmentation0.89185983
109MP0005195_abnormal_posterior_eye0.89166834
110MP0002063_abnormal_learning/memory/cond0.89109371
111MP0000639_abnormal_adrenal_gland0.88830273
112MP0000678_abnormal_parathyroid_gland0.87164929
113MP0002249_abnormal_larynx_morphology0.87129415
114MP0002234_abnormal_pharynx_morphology0.86574602
115MP0009333_abnormal_splenocyte_physiolog0.85897878
116MP0002138_abnormal_hepatobiliary_system0.85583140
117MP0002295_abnormal_pulmonary_circulatio0.84951351
118MP0005257_abnormal_intraocular_pressure0.83988261
119MP0010329_abnormal_lipoprotein_level0.83481876
120MP0003567_abnormal_fetal_cardiomyocyte0.83042168
121MP0003119_abnormal_digestive_system0.82421843
122MP0005220_abnormal_exocrine_pancreas0.82049563
123MP0001764_abnormal_homeostasis0.80699479
124MP0005332_abnormal_amino_acid0.78674247
125MP0002638_abnormal_pupillary_reflex0.76642718
126MP0000762_abnormal_tongue_morphology0.73316715
127MP0005248_abnormal_Harderian_gland0.72602932
128MP0004885_abnormal_endolymph0.71334229
129MP0002796_impaired_skin_barrier0.70663276
130MP0002233_abnormal_nose_morphology0.69805345
131MP0002210_abnormal_sex_determination0.68834091
132MP0004233_abnormal_muscle_weight0.68387223
133MP0002572_abnormal_emotion/affect_behav0.66695295
134MP0003635_abnormal_synaptic_transmissio0.65164613
135MP0003699_abnormal_female_reproductive0.64658495
136MP0000631_abnormal_neuroendocrine_gland0.64638806
137MP0002736_abnormal_nociception_after0.63865850
138MP0002168_other_aberrant_phenotype0.62093578
139MP0002177_abnormal_outer_ear0.61272766
140MP0004484_altered_response_of0.60729201
141MP0002882_abnormal_neuron_morphology0.59758016
142MP0006072_abnormal_retinal_apoptosis0.59641314
143MP0001915_intracranial_hemorrhage0.59250564
144MP0002229_neurodegeneration0.57356824
145MP0000767_abnormal_smooth_muscle0.57265220
146MP0002734_abnormal_mechanical_nocicepti0.57058720
147MP0000427_abnormal_hair_cycle0.56685173
148MP0001529_abnormal_vocalization0.55676691
149MP0002161_abnormal_fertility/fecundity0.55602343
150MP0002152_abnormal_brain_morphology0.53763334
151MP0005551_abnormal_eye_electrophysiolog0.52520855
152MP0001919_abnormal_reproductive_system0.51926903
153MP0000653_abnormal_sex_gland0.51066539
154MP0003252_abnormal_bile_duct0.48276015
155MP0003698_abnormal_male_reproductive0.47494661
156MP0002272_abnormal_nervous_system0.47133952
157MP0001968_abnormal_touch/_nociception0.45139499
158MP0000371_diluted_coat_color0.44050011

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.35792503
2Oligodactyly (hands) (HP:0001180)4.94686479
3Abnormality of macular pigmentation (HP:0008002)4.82149324
4Abnormality of abdominal situs (HP:0011620)4.46371461
5Abdominal situs inversus (HP:0003363)4.46371461
6Pancreatic cysts (HP:0001737)4.41139566
7Male infertility (HP:0003251)4.21973477
8Adrenal hypoplasia (HP:0000835)4.21960564
9Pancreatic fibrosis (HP:0100732)4.09592399
10Severe visual impairment (HP:0001141)3.88163321
11Hypoplasia of the iris (HP:0007676)3.70170841
12Septate vagina (HP:0001153)3.68718801
13Abnormal ciliary motility (HP:0012262)3.66073807
14Split foot (HP:0001839)3.61402563
15Abnormal respiratory motile cilium morphology (HP:0005938)3.60123737
16Abnormal respiratory epithelium morphology (HP:0012253)3.60123737
17Hyperventilation (HP:0002883)3.53443651
18Abnormal respiratory motile cilium physiology (HP:0012261)3.51694797
19Anosmia (HP:0000458)3.48022391
20Oligodactyly (HP:0012165)3.44906292
21Abnormality of midbrain morphology (HP:0002418)3.37122535
22Molar tooth sign on MRI (HP:0002419)3.37122535
23Nephronophthisis (HP:0000090)3.36781407
24Abnormality of the renal cortex (HP:0011035)3.32578220
25Submucous cleft hard palate (HP:0000176)3.29740248
26Dynein arm defect of respiratory motile cilia (HP:0012255)3.29738179
27Absent/shortened dynein arms (HP:0200106)3.29738179
283-Methylglutaconic aciduria (HP:0003535)3.25110242
29Absent hand (HP:0004050)3.13515298
30Congenital stationary night blindness (HP:0007642)3.13271920
31Amyloidosis (HP:0011034)3.13007954
32Congenital sensorineural hearing impairment (HP:0008527)3.06141505
33Abnormality of the renal medulla (HP:0100957)3.00517530
34Febrile seizures (HP:0002373)2.97709222
35Abnormality of the right ventricle (HP:0001707)2.90238140
36Medial flaring of the eyebrow (HP:0010747)2.89801547
37Gait imbalance (HP:0002141)2.84618678
38Retinal dysplasia (HP:0007973)2.81565053
39Rhinitis (HP:0012384)2.80599900
40Attenuation of retinal blood vessels (HP:0007843)2.80419972
41Oligodontia (HP:0000677)2.76874596
42Congenital primary aphakia (HP:0007707)2.75935680
43Methylmalonic acidemia (HP:0002912)2.75565287
44High anterior hairline (HP:0009890)2.75182006
45Focal motor seizures (HP:0011153)2.75030939
46Limb dystonia (HP:0002451)2.67141665
47Sclerocornea (HP:0000647)2.66127844
48Chronic hepatic failure (HP:0100626)2.64746347
49Aplasia/Hypoplasia of the lens (HP:0008063)2.64464949
50Type II lissencephaly (HP:0007260)2.63743215
51Nephrogenic diabetes insipidus (HP:0009806)2.62401264
52Abnormality of cochlea (HP:0000375)2.61435588
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56634758
54Renal cortical cysts (HP:0000803)2.53915669
55Parakeratosis (HP:0001036)2.53227502
56Persistence of primary teeth (HP:0006335)2.50408642
57Upper limb muscle weakness (HP:0003484)2.49791268
58Abolished electroretinogram (ERG) (HP:0000550)2.49728811
59Syncope (HP:0001279)2.49165552
60Abnormal biliary tract physiology (HP:0012439)2.45397976
61Bile duct proliferation (HP:0001408)2.45397976
62Tubulointerstitial nephritis (HP:0001970)2.43929397
63Pendular nystagmus (HP:0012043)2.42742141
64Severe Myopia (HP:0011003)2.41628857
65Tubular atrophy (HP:0000092)2.37970644
66Broad-based gait (HP:0002136)2.36225305
67Abnormality of alanine metabolism (HP:0010916)2.35704051
68Hyperalaninemia (HP:0003348)2.35704051
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35704051
70Progressive inability to walk (HP:0002505)2.28151779
71Methylmalonic aciduria (HP:0012120)2.28104451
72Abnormality of the diencephalon (HP:0010662)2.28046313
73Acute necrotizing encephalopathy (HP:0006965)2.27720508
74Concave nail (HP:0001598)2.26898398
75Gaze-evoked nystagmus (HP:0000640)2.26775972
76Polyuria (HP:0000103)2.24873326
77Increased corneal curvature (HP:0100692)2.23686798
78Keratoconus (HP:0000563)2.23686798
79Abnormal number of incisors (HP:0011064)2.23663082
80Protruding tongue (HP:0010808)2.23254719
81Abnormality of the intervertebral disk (HP:0005108)2.20550363
82Lissencephaly (HP:0001339)2.20280143
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.18862504
84Erectile abnormalities (HP:0100639)2.17635362
85Torticollis (HP:0000473)2.16605684
86Anencephaly (HP:0002323)2.15791674
87Preaxial hand polydactyly (HP:0001177)2.15722473
88Mitochondrial inheritance (HP:0001427)2.13274269
89Poor coordination (HP:0002370)2.11567493
90Xerostomia (HP:0000217)2.11508965
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.11417785
92Bony spicule pigmentary retinopathy (HP:0007737)2.11386939
93Hypothermia (HP:0002045)2.11253023
94Abnormality of the pons (HP:0007361)2.10499436
95Vaginal atresia (HP:0000148)2.10383552
96Increased CSF lactate (HP:0002490)2.09875618
97Bronchiectasis (HP:0002110)2.09641845
98Cystic liver disease (HP:0006706)2.08870152
99Acute encephalopathy (HP:0006846)2.07631331
100Alveolar cell carcinoma (HP:0006519)2.07046114
101Midline defect of the nose (HP:0004122)2.05966599
102Congenital hepatic fibrosis (HP:0002612)2.05926223
103Narrow nasal bridge (HP:0000446)2.05525119
104Abnormality of homocysteine metabolism (HP:0010919)2.04933415
105Homocystinuria (HP:0002156)2.04933415
106Cerebellar dysplasia (HP:0007033)2.04475137
107Progressive macrocephaly (HP:0004481)2.04423792
108Exotropia (HP:0000577)2.04296311
109Hypoplastic pelvis (HP:0008839)2.04024600
110Multiple enchondromatosis (HP:0005701)2.01892452
111True hermaphroditism (HP:0010459)2.01264898
112Hypoplastic left heart (HP:0004383)1.99575288
113Facial cleft (HP:0002006)1.97924092
114Skull defect (HP:0001362)1.96695603
115Inability to walk (HP:0002540)1.96346106
116Focal seizures (HP:0007359)1.95656799
117Male pseudohermaphroditism (HP:0000037)1.95048072
118Genital tract atresia (HP:0001827)1.95005580
119Bilateral microphthalmos (HP:0007633)1.92633300
120Stroke (HP:0001297)1.91457451
121Neoplasm of the tracheobronchial system (HP:0100552)1.90711577
122Constricted visual fields (HP:0001133)1.90385079
123Large for gestational age (HP:0001520)1.89811452
124Abnormal hair whorl (HP:0010721)1.89795258
125Patellar aplasia (HP:0006443)1.89499545
126Progressive cerebellar ataxia (HP:0002073)1.88705339
127Supernumerary ribs (HP:0005815)1.88479099
128Hypoplasia of the pons (HP:0012110)1.87979641
129Furrowed tongue (HP:0000221)1.87438611
130Abnormal mitochondria in muscle tissue (HP:0008316)1.87063533
131Retinitis pigmentosa (HP:0000510)1.86754586
132Aplasia/Hypoplasia of the patella (HP:0006498)1.84790769
133Left ventricular hypertrophy (HP:0001712)1.83190688
134Hyperglycinuria (HP:0003108)1.82790503
135Bifid tongue (HP:0010297)1.82502044
136Severe muscular hypotonia (HP:0006829)1.81958133
137Abnormality of the labia minora (HP:0012880)1.81859987
138Atonic seizures (HP:0010819)1.81570519
139Atelectasis (HP:0100750)1.81004413
140Right ventricular cardiomyopathy (HP:0011663)1.80786497
141Abnormal urine output (HP:0012590)1.80507057
142Renal Fanconi syndrome (HP:0001994)1.80429519
143Hemiparesis (HP:0001269)1.80241708
144Abnormality of calcium-phosphate metabolism (HP:0100530)1.78979836
145Postaxial foot polydactyly (HP:0001830)1.77946381
146Stomach cancer (HP:0012126)1.77530861
147Morphological abnormality of the inner ear (HP:0011390)1.76973689
148Hypoplastic heart (HP:0001961)1.76852220
149Congenital, generalized hypertrichosis (HP:0004540)1.76147860
150Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76104346
151Chronic otitis media (HP:0000389)1.75926592
152Fair hair (HP:0002286)1.75924599
153Spontaneous abortion (HP:0005268)1.75719167
154Scapular winging (HP:0003691)1.75068974
155Volvulus (HP:0002580)1.73695759
156Optic disc pallor (HP:0000543)1.73534853
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73232447
158Renovascular hypertension (HP:0100817)1.72763558
159Absent speech (HP:0001344)1.72628964
160Supernumerary spleens (HP:0009799)1.72442896
161Infertility (HP:0000789)1.71093359
162Decreased central vision (HP:0007663)1.70842751
163Polydipsia (HP:0001959)1.69639264
164Abnormal drinking behavior (HP:0030082)1.69639264
165Abnormality of renal resorption (HP:0011038)1.69435629
166Dialeptic seizures (HP:0011146)1.69248222
167Lipid accumulation in hepatocytes (HP:0006561)1.69116337
168Breech presentation (HP:0001623)1.68749972
169Glycosuria (HP:0003076)1.68664633
170Abnormality of urine glucose concentration (HP:0011016)1.68664633
171Intestinal atresia (HP:0011100)1.68011034
172Recurrent sinusitis (HP:0011108)1.66927738
173Chromsome breakage (HP:0040012)1.66690289
174Optic neuritis (HP:0100653)1.66072801
175Retrobulbar optic neuritis (HP:0100654)1.66072801
176Chronic sinusitis (HP:0011109)1.65446250
177Abnormal rod and cone electroretinograms (HP:0008323)1.65085081
178Joint hemorrhage (HP:0005261)1.64964899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF8.76305229
2RIPK17.81189366
3FRK5.24559723
4PIM25.11227617
5BRAF4.44818263
6ZAK3.31469621
7TAOK33.11648144
8RAF12.81170954
9ADRBK22.66713952
10MAP4K22.52373705
11TLK12.47696426
12TAOK12.46639394
13WNK32.04664706
14PRPF4B1.96968670
15CCNB11.95753107
16WNK41.94506775
17INSRR1.90748111
18DDR21.79540317
19TGFBR21.77765519
20TAOK21.77724372
21CASK1.74342740
22PDK21.69285240
23DMPK1.57908939
24PRKD31.51499621
25MAP3K31.49013465
26TXK1.44256939
27PNCK1.40861913
28MKNK21.39411116
29STK241.39209352
30PINK11.35336396
31TRIM281.34597990
32MST41.33948858
33TYRO31.27688595
34VRK11.23514807
35DAPK21.20913394
36ICK1.19636062
37MAP3K111.19546553
38LMTK21.17056560
39OXSR11.15259596
40BRSK21.14554797
41PLK31.14014655
42ACVR1B1.12347364
43PAK31.11199688
44FGFR21.09219324
45EIF2AK31.07927147
46MAP3K41.07526960
47NTRK31.04134016
48FGR1.03618632
49SRPK11.01876403
50BMPR1B0.97880303
51STK160.95776293
52BCKDK0.92969589
53MAP2K30.91734463
54STK38L0.90727177
55AKT30.87948936
56PIK3CA0.85266434
57CSNK1A1L0.84936242
58ADRBK10.82230499
59TEC0.82150492
60MAP3K60.81407037
61CAMKK20.80647659
62HIPK20.79923669
63STK30.77707211
64CSNK1G30.77595262
65BCR0.77307821
66GRK50.76504381
67CAMK2G0.75213975
68TGFBR10.74627602
69ERBB40.74468600
70GRK70.74344502
71RPS6KA20.74073409
72MAP3K130.73090612
73KIT0.73011181
74PLK20.72997378
75LATS20.70585129
76CSNK1G10.69469223
77MATK0.67624061
78NTRK20.67484613
79MAPK150.64898000
80PRKCI0.63246670
81CSNK1G20.63219137
82CHEK20.62989022
83BMPR20.62831265
84FLT30.61508370
85CDC42BPA0.60503937
86LATS10.59490458
87EPHB20.58423669
88WEE10.58339435
89PRKCE0.55496752
90PKN10.54489343
91MUSK0.52662432
92PHKG20.51871854
93PHKG10.51871854
94PDGFRA0.51703519
95CDC70.51404645
96IKBKB0.50569636
97PRKACA0.49081146
98PRKCQ0.48660588
99CDK30.48217410
100PLK40.47716508
101ERBB30.47335736
102MKNK10.47182363
103TNIK0.46813489
104TTK0.46790854
105MARK30.45656467
106STK110.43870178
107PRKCH0.43561496
108GSK3A0.43238369
109PLK10.43026528
110MAPKAPK20.42820502
111CSNK1D0.40533909
112ITK0.40531496
113PTK2B0.40327454
114RPS6KC10.39764977
115RPS6KL10.39764977
116RPS6KA50.39670673
117PRKG20.39484634
118ATR0.39101553
119MAP3K70.39069041
120SGK10.37262778
121TAF10.36515928
122TSSK60.36479934
123MAPK130.36400978
124ATM0.36218698
125CAMK10.35162977
126MAP2K60.35156865
127MAP2K70.33735188
128PIM10.33644126
129SYK0.33147480
130CSNK1A10.32709223
131RPS6KA60.32009534
132MAP3K50.31430918
133PRKD10.30954998
134STK380.30914032
135SGK20.30776538
136CDK80.29053220
137CSK0.28673961
138AURKA0.26974150
139TRIB30.26844624
140KSR20.26179697
141RET0.25622078
142RPS6KA10.25469564
143HCK0.25049452
144MAPKAPK30.23290313
145CAMK2B0.23160974
146NUAK10.22727446
147ROCK10.22685786
148DYRK20.21748197
149MAP3K10.21295442
150PRKG10.20359917
151ABL10.20138452
152CAMK2D0.19717162
153MARK10.19215394
154MOS0.19113345
155SGK4940.18716213
156SGK2230.18716213
157MAPK90.18257869
158STK390.15275422
159IRAK40.15102698
160NLK0.14636798
161CAMK2A0.12761621
162IRAK10.12542338
163GRK10.10643713
164PRKCG0.09765695

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.66663530
2Morphine addiction_Homo sapiens_hsa050323.06716834
3Circadian entrainment_Homo sapiens_hsa047132.76418213
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.73356978
5Phototransduction_Homo sapiens_hsa047442.63614890
6Collecting duct acid secretion_Homo sapiens_hsa049662.62003225
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57964850
8GABAergic synapse_Homo sapiens_hsa047272.50152977
9Serotonergic synapse_Homo sapiens_hsa047262.46186434
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45981865
11Nitrogen metabolism_Homo sapiens_hsa009102.44929976
12Homologous recombination_Homo sapiens_hsa034402.44295554
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38509835
14Cholinergic synapse_Homo sapiens_hsa047252.34961502
15Butanoate metabolism_Homo sapiens_hsa006502.31658644
16Glutamatergic synapse_Homo sapiens_hsa047242.29888618
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.29392417
18Protein export_Homo sapiens_hsa030602.26610105
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24126520
20Oxidative phosphorylation_Homo sapiens_hsa001902.15030785
21Dopaminergic synapse_Homo sapiens_hsa047281.95348147
22Selenocompound metabolism_Homo sapiens_hsa004501.89361346
23Endometrial cancer_Homo sapiens_hsa052131.88663891
24Pyruvate metabolism_Homo sapiens_hsa006201.87617543
25Pancreatic cancer_Homo sapiens_hsa052121.81165262
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.73586057
27Parkinsons disease_Homo sapiens_hsa050121.72343025
28Nicotine addiction_Homo sapiens_hsa050331.72200525
29Ras signaling pathway_Homo sapiens_hsa040141.71331267
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.70304134
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67589758
32Fanconi anemia pathway_Homo sapiens_hsa034601.65188039
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64648304
34Colorectal cancer_Homo sapiens_hsa052101.56491123
35Proteasome_Homo sapiens_hsa030501.53950250
36Hepatitis C_Homo sapiens_hsa051601.52122033
37beta-Alanine metabolism_Homo sapiens_hsa004101.49034837
38Ovarian steroidogenesis_Homo sapiens_hsa049131.47558369
39Sulfur relay system_Homo sapiens_hsa041221.47196733
40Taste transduction_Homo sapiens_hsa047421.39024400
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36332223
42One carbon pool by folate_Homo sapiens_hsa006701.34992858
43Tight junction_Homo sapiens_hsa045301.32863549
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.28197407
45RNA degradation_Homo sapiens_hsa030181.26874240
46Tryptophan metabolism_Homo sapiens_hsa003801.18553098
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16662837
48Huntingtons disease_Homo sapiens_hsa050161.16474841
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14726187
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.14307626
51Mismatch repair_Homo sapiens_hsa034301.14041332
52Nucleotide excision repair_Homo sapiens_hsa034201.13783489
53Peroxisome_Homo sapiens_hsa041461.12255131
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11473376
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11092082
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09189035
57Chemokine signaling pathway_Homo sapiens_hsa040621.07049791
58Arginine and proline metabolism_Homo sapiens_hsa003301.06159981
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03336666
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01869723
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.01746360
62Steroid biosynthesis_Homo sapiens_hsa001001.01518522
63Fat digestion and absorption_Homo sapiens_hsa049751.00959406
64ABC transporters_Homo sapiens_hsa020101.00819661
65Alzheimers disease_Homo sapiens_hsa050101.00578989
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99965818
67Asthma_Homo sapiens_hsa053100.92562160
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91852403
69Cardiac muscle contraction_Homo sapiens_hsa042600.90286054
70Basal cell carcinoma_Homo sapiens_hsa052170.90092844
71Non-homologous end-joining_Homo sapiens_hsa034500.88926880
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87755090
73Histidine metabolism_Homo sapiens_hsa003400.87697340
74Type I diabetes mellitus_Homo sapiens_hsa049400.86688719
75GnRH signaling pathway_Homo sapiens_hsa049120.86358791
76Caffeine metabolism_Homo sapiens_hsa002320.84858264
77Chronic myeloid leukemia_Homo sapiens_hsa052200.83874814
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82720428
79Synaptic vesicle cycle_Homo sapiens_hsa047210.82630928
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.80488330
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80106542
82* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78858714
83Graft-versus-host disease_Homo sapiens_hsa053320.74890796
84Alcoholism_Homo sapiens_hsa050340.74268375
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73805241
86VEGF signaling pathway_Homo sapiens_hsa043700.71560919
87cAMP signaling pathway_Homo sapiens_hsa040240.71520235
88Primary immunodeficiency_Homo sapiens_hsa053400.70841960
89Pathways in cancer_Homo sapiens_hsa052000.69126403
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68578595
91Fatty acid metabolism_Homo sapiens_hsa012120.68546224
92Linoleic acid metabolism_Homo sapiens_hsa005910.68510737
93Allograft rejection_Homo sapiens_hsa053300.67572070
94Autoimmune thyroid disease_Homo sapiens_hsa053200.66024628
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65382021
96Glycerolipid metabolism_Homo sapiens_hsa005610.64908699
97Vitamin digestion and absorption_Homo sapiens_hsa049770.64545214
98Melanoma_Homo sapiens_hsa052180.63355225
99Metabolic pathways_Homo sapiens_hsa011000.63069131
100Toxoplasmosis_Homo sapiens_hsa051450.61619422
101Ether lipid metabolism_Homo sapiens_hsa005650.61438063
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61202421
103RNA polymerase_Homo sapiens_hsa030200.59420690
104Calcium signaling pathway_Homo sapiens_hsa040200.57472843
105Fatty acid elongation_Homo sapiens_hsa000620.57427156
106Fatty acid biosynthesis_Homo sapiens_hsa000610.57177392
107Chemical carcinogenesis_Homo sapiens_hsa052040.54831886
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.53771195
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52488161
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52278473
111Arachidonic acid metabolism_Homo sapiens_hsa005900.49932867
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49385765
113Sulfur metabolism_Homo sapiens_hsa009200.48340791
114ErbB signaling pathway_Homo sapiens_hsa040120.47945434
115* Insulin secretion_Homo sapiens_hsa049110.47577870
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47572842
117Apoptosis_Homo sapiens_hsa042100.47348116
118* Vascular smooth muscle contraction_Homo sapiens_hsa042700.47198381
119Fatty acid degradation_Homo sapiens_hsa000710.46452290
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.46299014
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45741283
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45667704
123TNF signaling pathway_Homo sapiens_hsa046680.42718996
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41573922
125Pyrimidine metabolism_Homo sapiens_hsa002400.40712836
126Hedgehog signaling pathway_Homo sapiens_hsa043400.40580429
127Prostate cancer_Homo sapiens_hsa052150.39803450
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39675564
129Non-small cell lung cancer_Homo sapiens_hsa052230.39488317
130Other glycan degradation_Homo sapiens_hsa005110.39196431
131RNA transport_Homo sapiens_hsa030130.39068156
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39059899
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38818146
134Hippo signaling pathway_Homo sapiens_hsa043900.38784863
135Axon guidance_Homo sapiens_hsa043600.37837830
136Oocyte meiosis_Homo sapiens_hsa041140.37441059
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.36031539
138Rheumatoid arthritis_Homo sapiens_hsa053230.35616637
139Oxytocin signaling pathway_Homo sapiens_hsa049210.35511918
140Regulation of autophagy_Homo sapiens_hsa041400.35399932
141Sphingolipid metabolism_Homo sapiens_hsa006000.35308129
142Retinol metabolism_Homo sapiens_hsa008300.35288596
143Rap1 signaling pathway_Homo sapiens_hsa040150.34589004
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34408895
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.32307828
146Wnt signaling pathway_Homo sapiens_hsa043100.32279962
147Small cell lung cancer_Homo sapiens_hsa052220.31095865
148Purine metabolism_Homo sapiens_hsa002300.30136516
149Salivary secretion_Homo sapiens_hsa049700.29138667
150Insulin signaling pathway_Homo sapiens_hsa049100.27032341
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26867746
152Basal transcription factors_Homo sapiens_hsa030220.26847378
153Propanoate metabolism_Homo sapiens_hsa006400.26728384
154Long-term depression_Homo sapiens_hsa047300.26608941
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25781998
156Renal cell carcinoma_Homo sapiens_hsa052110.25449687
157Gastric acid secretion_Homo sapiens_hsa049710.24673204
158Estrogen signaling pathway_Homo sapiens_hsa049150.24348820
159Melanogenesis_Homo sapiens_hsa049160.24256492
160Dilated cardiomyopathy_Homo sapiens_hsa054140.24043523
161Mineral absorption_Homo sapiens_hsa049780.22382275

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »