ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of immune response to tumor cell (GO:0002839)	7.24955440
2	regulation of immune response to tumor cell (GO:0002837)	7.24955440
3	regulation of response to tumor cell (GO:0002834)	7.24955440
4	positive regulation of response to tumor cell (GO:0002836)	7.24955440
5	activated T cell proliferation (GO:0050798)	6.06281108
6	behavioral response to nicotine (GO:0035095)	6.04156064
7	positive regulation of protein homooligomerization (GO:0032464)	5.19078049
8	regulation of RIG-I signaling pathway (GO:0039535)	4.85594332
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.77727288
10	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	4.59346170
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.20772894
12	negative regulation of reactive oxygen species metabolic process (GO:2000378)	4.16728389
13	negative regulation of necroptotic process (GO:0060546)	4.02247180
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.88331128
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.88331128
16	NADH dehydrogenase complex assembly (GO:0010257)	3.88331128
17	lung lobe morphogenesis (GO:0060463)	3.83042059
18	negative regulation of necrotic cell death (GO:0060547)	3.81680477
19	protein neddylation (GO:0045116)	3.75496951
20	neuronal action potential (GO:0019228)	3.65305922
21	postsynaptic membrane organization (GO:0001941)	3.56997607
22	ovulation cycle (GO:0042698)	3.56618354
23	respiratory chain complex IV assembly (GO:0008535)	3.53160570
24	NIK/NF-kappaB signaling (GO:0038061)	3.51800131
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.49795597
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42719024
27	atrial cardiac muscle cell action potential (GO:0086014)	3.40208235
28	protein complex biogenesis (GO:0070271)	3.36258688
29	neural tube formation (GO:0001841)	3.27476773
30	sulfation (GO:0051923)	3.24449010
31	presynaptic membrane organization (GO:0097090)	3.21265714
32	presynaptic membrane assembly (GO:0097105)	3.20022397
33	lymphangiogenesis (GO:0001946)	3.14513202
34	auditory behavior (GO:0031223)	3.13566486
35	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12970869
36	regulation of protein homooligomerization (GO:0032462)	3.08679098
37	regulation of meiosis I (GO:0060631)	3.08500794
38	tryptophan catabolic process (GO:0006569)	3.07504265
39	indole-containing compound catabolic process (GO:0042436)	3.07504265
40	indolalkylamine catabolic process (GO:0046218)	3.07504265
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.07094856
42	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.00094108
43	regulation of T cell chemotaxis (GO:0010819)	2.98130414
44	positive regulation of T cell chemotaxis (GO:0010820)	2.98130414
45	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.97730808
46	kynurenine metabolic process (GO:0070189)	2.95279460
47	ATP synthesis coupled proton transport (GO:0015986)	2.93883672
48	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.93883672
49	mannosylation (GO:0097502)	2.91173046
50	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.87279207
51	piRNA metabolic process (GO:0034587)	2.85826497
52	behavioral response to ethanol (GO:0048149)	2.84632057
53	axonemal dynein complex assembly (GO:0070286)	2.83584076
54	positive regulation of meiosis (GO:0045836)	2.81667869
55	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.80454104
56	prepulse inhibition (GO:0060134)	2.76787019
57	nucleotide transmembrane transport (GO:1901679)	2.76484716
58	multicellular organism reproduction (GO:0032504)	2.74090690
59	peristalsis (GO:0030432)	2.73391807
60	synaptic transmission, cholinergic (GO:0007271)	2.73070002
61	cilium or flagellum-dependent cell motility (GO:0001539)	2.72962081
62	necroptotic process (GO:0070266)	2.71470296
63	kidney morphogenesis (GO:0060993)	2.71384285
64	glutamate receptor signaling pathway (GO:0007215)	2.67537489
65	cytochrome complex assembly (GO:0017004)	2.66768173
66	positive regulation of tolerance induction (GO:0002645)	2.65524287
67	negative regulation of mast cell activation (GO:0033004)	2.65256220
68	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.63372761
69	sympathetic nervous system development (GO:0048485)	2.63288455
70	respiratory electron transport chain (GO:0022904)	2.62338076
71	amine catabolic process (GO:0009310)	2.62090642
72	cellular biogenic amine catabolic process (GO:0042402)	2.62090642
73	electron transport chain (GO:0022900)	2.61763339
74	positive regulation of mitochondrial fission (GO:0090141)	2.61634793
75	epithelial cilium movement (GO:0003351)	2.61284339
76	response to pheromone (GO:0019236)	2.60979099
77	negative regulation of telomere maintenance (GO:0032205)	2.59789461
78	positive regulation of meiotic cell cycle (GO:0051446)	2.59328725
79	nephron tubule morphogenesis (GO:0072078)	2.56890081
80	nephron epithelium morphogenesis (GO:0072088)	2.56890081
81	regulation of telomere maintenance (GO:0032204)	2.56551434
82	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.53674300
83	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.53674300
84	positive regulation of amino acid transport (GO:0051957)	2.53481637
85	synaptic transmission, glutamatergic (GO:0035249)	2.53265899
86	cilium morphogenesis (GO:0060271)	2.52916166
87	positive regulation of guanylate cyclase activity (GO:0031284)	2.52818671
88	alanine transport (GO:0032328)	2.52027629
89	limb bud formation (GO:0060174)	2.51883256
90	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.51079108
91	nonmotile primary cilium assembly (GO:0035058)	2.50512684
92	cardiac right ventricle morphogenesis (GO:0003215)	2.47929633
93	regulation of respiratory system process (GO:0044065)	2.47846586
94	protein localization to synapse (GO:0035418)	2.47667076
95	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.47525435
96	T cell mediated immunity (GO:0002456)	2.46233810
97	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.45422309
98	positive regulation of synapse assembly (GO:0051965)	2.45178076
99	indolalkylamine metabolic process (GO:0006586)	2.44748689
100	pyrimidine nucleobase catabolic process (GO:0006208)	2.44299761

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.21203942
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.82617657
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.37966754
4	VDR_22108803_ChIP-Seq_LS180_Human	3.35016183
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.04356638
6	EWS_26573619_Chip-Seq_HEK293_Human	2.64542164
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.58968290
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.52942240
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.51470219
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.45127621
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.40334269
12	FUS_26573619_Chip-Seq_HEK293_Human	2.35960807
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.26312681
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25843988
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18669186
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17489089
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.08137225
18	P300_19829295_ChIP-Seq_ESCs_Human	2.04815929
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.98932797
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95558370
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.93399280
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.92348567
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.87230725
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.86773521
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85163184
26	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.78680191
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.75527917
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70260009
29	GATA1_22025678_ChIP-Seq_K562_Human	1.70055144
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.66563032
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65138316
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.63935238
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63726962
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.58888383
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57657924
36	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.56843328
37	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.54107305
38	AR_25329375_ChIP-Seq_VCAP_Human	1.51836210
39	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.50494043
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46440116
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46327660
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45841276
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.43114285
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.42946816
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42946816
46	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.42914144
47	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.41069112
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40116601
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36879192
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.35139363
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34273487
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33464575
53	STAT3_23295773_ChIP-Seq_U87_Human	1.33121852
54	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.32655661
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30293485
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30293485
57	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.29661503
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27564704
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25478656
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.23973833
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19940675
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19618115
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18376510
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17976838
65	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16577942
66	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.15965783
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15039284
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14663740
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13082895
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13082895
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12861292
72	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.12848705
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12334530
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10376752
75	ELK1_19687146_ChIP-ChIP_HELA_Human	1.09677363
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07615968
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07615968
78	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05946282
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04814875
80	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.04222629
81	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03875481
82	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.03859298
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03798900
84	TCF4_23295773_ChIP-Seq_U87_Human	1.03466272
85	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01332957
86	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.99844110
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99417761
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99400046
89	ERA_21632823_ChIP-Seq_H3396_Human	0.99332666
90	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.98211329
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97846619
92	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97668253
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97585200
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96266444
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95780806
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95217237
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94987543
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94121902
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93481297
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92706764

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	3.38067166
2	MP0001529_abnormal_vocalization	3.31778052
3	MP0001968_abnormal_touch/_nociception	3.06132891
4	MP0002653_abnormal_ependyma_morphology	3.05726659
5	MP0003787_abnormal_imprinting	3.04808520
6	MP0001346_abnormal_lacrimal_gland	2.96943246
7	MP0002102_abnormal_ear_morphology	2.86410304
8	MP0001348_abnormal_lacrimal_gland	2.83350329
9	MP0004885_abnormal_endolymph	2.71606136
10	MP0008877_abnormal_DNA_methylation	2.69394882
11	MP0003011_delayed_dark_adaptation	2.52623221
12	MP0000569_abnormal_digit_pigmentation	2.35231089
13	MP0002822_catalepsy	2.24197518
14	MP0004142_abnormal_muscle_tone	2.21883670
15	MP0002876_abnormal_thyroid_physiology	2.11406215
16	MP0003880_abnormal_central_pattern	2.03693765
17	MP0005423_abnormal_somatic_nervous	1.97278076
18	MP0005167_abnormal_blood-brain_barrier	1.96419131
19	MP0005551_abnormal_eye_electrophysiolog	1.80824427
20	MP0002638_abnormal_pupillary_reflex	1.75712607
21	MP0002272_abnormal_nervous_system	1.75071090
22	MP0003315_abnormal_perineum_morphology	1.73944479
23	MP0003890_abnormal_embryonic-extraembry	1.73788333
24	MP0002735_abnormal_chemical_nociception	1.72559640
25	MP0001986_abnormal_taste_sensitivity	1.67794531
26	MP0001486_abnormal_startle_reflex	1.67636251
27	MP0003646_muscle_fatigue	1.65527357
28	MP0005084_abnormal_gallbladder_morpholo	1.65147664
29	MP0009379_abnormal_foot_pigmentation	1.64365773
30	MP0004133_heterotaxia	1.63907441
31	MP0006292_abnormal_olfactory_placode	1.62308869
32	MP0002234_abnormal_pharynx_morphology	1.59399703
33	MP0005379_endocrine/exocrine_gland_phen	1.57480908
34	MP0006276_abnormal_autonomic_nervous	1.57065138
35	MP0009046_muscle_twitch	1.51661328
36	MP0009745_abnormal_behavioral_response	1.50734742
37	MP0002277_abnormal_respiratory_mucosa	1.50277883
38	MP0002733_abnormal_thermal_nociception	1.48095704
39	MP0002736_abnormal_nociception_after	1.44266899
40	MP0004859_abnormal_synaptic_plasticity	1.42469433
41	MP0002095_abnormal_skin_pigmentation	1.41893398
42	MP0002734_abnormal_mechanical_nocicepti	1.40795115
43	MP0000778_abnormal_nervous_system	1.35497648
44	MP0005174_abnormal_tail_pigmentation	1.34977111
45	MP0000631_abnormal_neuroendocrine_gland	1.32861976
46	MP0005253_abnormal_eye_physiology	1.32685132
47	MP0002064_seizures	1.30043427
48	MP0002572_abnormal_emotion/affect_behav	1.28678357
49	MP0003635_abnormal_synaptic_transmissio	1.28409575
50	MP0003136_yellow_coat_color	1.28341013
51	MP0006072_abnormal_retinal_apoptosis	1.27518905
52	MP0000427_abnormal_hair_cycle	1.25743815
53	MP0001984_abnormal_olfaction	1.24944161
54	MP0003121_genomic_imprinting	1.21431883
55	MP0003567_abnormal_fetal_cardiomyocyte	1.21041132
56	MP0001440_abnormal_grooming_behavior	1.18297489
57	MP0003137_abnormal_impulse_conducting	1.18206812
58	MP0002063_abnormal_learning/memory/cond	1.15395974
59	MP0001970_abnormal_pain_threshold	1.13494925
60	MP0003119_abnormal_digestive_system	1.12960214
61	MP0009384_cardiac_valve_regurgitation	1.12684191
62	MP0004215_abnormal_myocardial_fiber	1.09619051
63	MP0004924_abnormal_behavior	1.07739591
64	MP0005386_behavior/neurological_phenoty	1.07739591
65	MP0008789_abnormal_olfactory_epithelium	1.07564261
66	MP0002067_abnormal_sensory_capabilities	1.07361438
67	MP0001188_hyperpigmentation	1.05746806
68	MP0001879_abnormal_lymphatic_vessel	1.05034123
69	MP0002557_abnormal_social/conspecific_i	1.02475846
70	MP0001905_abnormal_dopamine_level	1.01587283
71	MP0006082_CNS_inflammation	0.97454855
72	MP0005310_abnormal_salivary_gland	0.94703371
73	MP0004270_analgesia	0.94313196
74	MP0000647_abnormal_sebaceous_gland	0.92938219
75	MP0002184_abnormal_innervation	0.91872811
76	MP0002938_white_spotting	0.91587017
77	MP0005187_abnormal_penis_morphology	0.90494016
78	MP0008872_abnormal_physiological_respon	0.90485097
79	MP0005499_abnormal_olfactory_system	0.89662470
80	MP0005394_taste/olfaction_phenotype	0.89662470
81	MP0000685_abnormal_immune_system	0.86659276
82	MP0010368_abnormal_lymphatic_system	0.86309570
83	MP0002751_abnormal_autonomic_nervous	0.84084995
84	MP0000372_irregular_coat_pigmentation	0.83453987
85	MP0003959_abnormal_lean_body	0.83013243
86	MP0002752_abnormal_somatic_nervous	0.81859329
87	MP0004742_abnormal_vestibular_system	0.81508548
88	MP0008875_abnormal_xenobiotic_pharmacok	0.80985746
89	MP0005389_reproductive_system_phenotype	0.80508475
90	MP0000015_abnormal_ear_pigmentation	0.79923533
91	MP0002928_abnormal_bile_duct	0.77440941
92	MP0003937_abnormal_limbs/digits/tail_de	0.77140700
93	MP0008007_abnormal_cellular_replicative	0.76958965
94	MP0000026_abnormal_inner_ear	0.76584447
95	MP0001485_abnormal_pinna_reflex	0.76399757
96	MP0000955_abnormal_spinal_cord	0.75782142
97	MP0002882_abnormal_neuron_morphology	0.73805072
98	MP0010386_abnormal_urinary_bladder	0.72892922
99	MP0001293_anophthalmia	0.70934763
100	MP0005410_abnormal_fertilization	0.68365822

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.06878511
2	Molar tooth sign on MRI (HP:0002419)	4.05786167
3	Abnormality of midbrain morphology (HP:0002418)	4.05786167
4	Pancreatic cysts (HP:0001737)	3.97610202
5	Nephronophthisis (HP:0000090)	3.71346055
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.67108592
7	Absent/shortened dynein arms (HP:0200106)	3.67108592
8	Pancreatic fibrosis (HP:0100732)	3.61510838
9	True hermaphroditism (HP:0010459)	3.44808533
10	Abnormality of the renal medulla (HP:0100957)	3.37179199
11	Congenital, generalized hypertrichosis (HP:0004540)	3.04414670
12	Widely spaced teeth (HP:0000687)	2.80626262
13	Acute necrotizing encephalopathy (HP:0006965)	2.77896733
14	Abnormality of alanine metabolism (HP:0010916)	2.76141212
15	Hyperalaninemia (HP:0003348)	2.76141212
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.76141212
17	Increased hepatocellular lipid droplets (HP:0006565)	2.75993585
18	Autoimmune thrombocytopenia (HP:0001973)	2.71247476
19	Exotropia (HP:0000577)	2.70320160
20	Hypoplasia of the uterus (HP:0000013)	2.68107508
21	Chronic hepatic failure (HP:0100626)	2.67805573
22	Progressive macrocephaly (HP:0004481)	2.67273631
23	Mitochondrial inheritance (HP:0001427)	2.66419360
24	Medial flaring of the eyebrow (HP:0010747)	2.66215903
25	Inability to walk (HP:0002540)	2.65095027
26	Renal Fanconi syndrome (HP:0001994)	2.63774512
27	Abnormal ciliary motility (HP:0012262)	2.63256816
28	Hyperglycinuria (HP:0003108)	2.61342814
29	Cystic liver disease (HP:0006706)	2.61152468
30	Dyskinesia (HP:0100660)	2.59793609
31	Abnormality of the renal cortex (HP:0011035)	2.57528419
32	3-Methylglutaconic aciduria (HP:0003535)	2.57274539
33	Absent speech (HP:0001344)	2.56574166
34	Progressive inability to walk (HP:0002505)	2.53109974
35	Increased IgM level (HP:0003496)	2.51702025
36	Ulnar claw (HP:0001178)	2.50786096
37	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.49272295
38	Furrowed tongue (HP:0000221)	2.48455669
39	Lipid accumulation in hepatocytes (HP:0006561)	2.43938397
40	Oligodactyly (hands) (HP:0001180)	2.42062943
41	Concave nail (HP:0001598)	2.40389577
42	Acute encephalopathy (HP:0006846)	2.38517768
43	Exertional dyspnea (HP:0002875)	2.33674408
44	Septo-optic dysplasia (HP:0100842)	2.32342950
45	Male pseudohermaphroditism (HP:0000037)	2.26288913
46	Hypoplastic labia majora (HP:0000059)	2.25148887
47	Abnormality of urine glucose concentration (HP:0011016)	2.24525019
48	Glycosuria (HP:0003076)	2.24525019
49	Hemiparesis (HP:0001269)	2.19614822
50	Increased CSF lactate (HP:0002490)	2.17619898
51	Tubular atrophy (HP:0000092)	2.16427944
52	Febrile seizures (HP:0002373)	2.16262374
53	Potter facies (HP:0002009)	2.14913186
54	Facial shape deformation (HP:0011334)	2.14913186
55	Birth length less than 3rd percentile (HP:0003561)	2.14168662
56	Sclerocornea (HP:0000647)	2.13072979
57	Hepatocellular necrosis (HP:0001404)	2.12377635
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12259134
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.12259134
60	Generalized hypopigmentation of hair (HP:0011358)	2.11412340
61	Hepatic necrosis (HP:0002605)	2.09718402
62	Polyphagia (HP:0002591)	2.09711949
63	Anencephaly (HP:0002323)	2.08622042
64	Abnormal number of erythroid precursors (HP:0012131)	2.08594725
65	Protruding tongue (HP:0010808)	2.07732064
66	Biliary tract neoplasm (HP:0100574)	2.07730614
67	Abnormality of glycine metabolism (HP:0010895)	2.06890002
68	Abnormality of serine family amino acid metabolism (HP:0010894)	2.06890002
69	Bile duct proliferation (HP:0001408)	2.06605629
70	Abnormal biliary tract physiology (HP:0012439)	2.06605629
71	Small hand (HP:0200055)	2.03029843
72	Abnormality of the labia majora (HP:0012881)	2.02932636
73	Abnormal mitochondria in muscle tissue (HP:0008316)	2.02706369
74	Increased corneal curvature (HP:0100692)	2.02383278
75	Keratoconus (HP:0000563)	2.02383278
76	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02174683
77	Reticulocytopenia (HP:0001896)	2.00229156
78	Abnormal drinking behavior (HP:0030082)	1.99004816
79	Polydipsia (HP:0001959)	1.99004816
80	Nephrogenic diabetes insipidus (HP:0009806)	1.98779015
81	Gait imbalance (HP:0002141)	1.97814501
82	Limb dystonia (HP:0002451)	1.95075930
83	Congenital hepatic fibrosis (HP:0002612)	1.93271043
84	Tubulointerstitial fibrosis (HP:0005576)	1.92308805
85	Hypoalbuminemia (HP:0003073)	1.92297134
86	Abnormal albumin level (HP:0012116)	1.92297134
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.88902965
88	Hypokalemic alkalosis (HP:0001949)	1.88105379
89	Congenital stationary night blindness (HP:0007642)	1.87742429
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87517566
91	Drooling (HP:0002307)	1.87414555
92	Abnormality of cells of the erythroid lineage (HP:0012130)	1.86952975
93	Broad-based gait (HP:0002136)	1.86125279
94	Supernumerary spleens (HP:0009799)	1.85308748
95	Abnormality of the labia minora (HP:0012880)	1.85290315
96	Narrow forehead (HP:0000341)	1.85138495
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84427465
98	Optic disc pallor (HP:0000543)	1.84144258
99	Congenital primary aphakia (HP:0007707)	1.83611031
100	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.83340250

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.25287385
2	BCR	4.67978268
3	INSRR	3.72194826
4	PDK2	3.69644257
5	MAPKAPK3	3.00100280
6	FRK	2.37481949
7	TSSK6	2.33659415
8	MAPK13	2.22991898
9	TGFBR2	2.21135646
10	EPHB2	2.19675162
11	MAPKAPK5	2.11658251
12	MARK1	2.06691610
13	MAPK15	2.04072741
14	TNIK	1.90321998
15	CASK	1.86730850
16	TLK1	1.76887776
17	EPHA3	1.73657635
18	EEF2K	1.71334660
19	FER	1.64361225
20	IRAK1	1.63154445
21	WNK3	1.54110420
22	DYRK2	1.52551585
23	CAMKK2	1.52475204
24	MARK3	1.51200347
25	PINK1	1.50040602
26	WEE1	1.48977679
27	WNK4	1.41038750
28	OXSR1	1.40483767
29	ADRBK2	1.39917997
30	CAMK1G	1.36106030
31	NUAK1	1.32730909
32	CAMK1D	1.32391307
33	RPS6KB2	1.31582783
34	EPHB1	1.17269376
35	BMPR1B	1.14808873
36	PRKD3	1.13837184
37	PBK	1.10997844
38	STK39	1.10867642
39	MINK1	0.99749998
40	GRK1	0.96248674
41	MAP3K4	0.95865731
42	PAK3	0.92534189
43	PRKCG	0.89920692
44	BRSK2	0.87619855
45	IRAK2	0.81707201
46	MAP2K7	0.81129967
47	PTK2B	0.80490194
48	FES	0.78861164
49	PRKCE	0.75527531
50	VRK1	0.73457028
51	CDK19	0.72463647
52	ACVR1B	0.71740020
53	CSNK1G2	0.71694813
54	STK3	0.68059732
55	AKT3	0.67780821
56	MAPK12	0.66733745
57	NLK	0.65742575
58	STK11	0.64339992
59	VRK2	0.62373142
60	CSNK1G1	0.62091254
61	CSNK1G3	0.62089484
62	TRIM28	0.61929733
63	MAP4K2	0.61859605
64	CSNK1A1L	0.58666692
65	NEK6	0.58567480
66	NTRK2	0.58385215
67	CDK3	0.56232596
68	STK16	0.53483675
69	ERBB2	0.49058152
70	TAOK1	0.47658540
71	CAMK1	0.43828421
72	NTRK3	0.41494546
73	CAMKK1	0.41466208
74	ZAK	0.40258497
75	ADRBK1	0.40064155
76	TRPM7	0.38992768
77	PIK3CA	0.38751930
78	PRKACA	0.38292068
79	CAMK2A	0.38190806
80	PRKAA2	0.37722320
81	CLK1	0.36977608
82	RPS6KA5	0.36841021
83	TAF1	0.36159619
84	CSNK1A1	0.33871967
85	MAP3K11	0.31223836
86	TAOK2	0.30978210
87	PRKACB	0.30868571
88	WNK1	0.30522076
89	IRAK4	0.26084738
90	CCNB1	0.25976601
91	MAP2K4	0.25737908
92	TGFBR1	0.25411854
93	IRAK3	0.25285791
94	TEC	0.23461129
95	CDK5	0.23353001
96	PIM1	0.22565766
97	CDC7	0.22419091
98	PRKCD	0.21863704
99	MAPKAPK2	0.21806984
100	HIPK2	0.21561798

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.66225614
2	Ribosome_Homo sapiens_hsa03010	3.10282557
3	Parkinsons disease_Homo sapiens_hsa05012	3.07135109
4	Nicotine addiction_Homo sapiens_hsa05033	2.80652691
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.51964618
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.48670614
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.47806244
8	Protein export_Homo sapiens_hsa03060	2.37869678
9	Phototransduction_Homo sapiens_hsa04744	2.32493998
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.14309292
11	Huntingtons disease_Homo sapiens_hsa05016	1.99574348
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96727463
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.94719914
14	Alzheimers disease_Homo sapiens_hsa05010	1.90895243
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87091793
16	Homologous recombination_Homo sapiens_hsa03440	1.67865630
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.61212256
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.60096218
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59347707
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58534005
21	Taste transduction_Homo sapiens_hsa04742	1.55964382
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.49272602
23	Chemical carcinogenesis_Homo sapiens_hsa05204	1.44923171
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43743836
25	RNA polymerase_Homo sapiens_hsa03020	1.41349869
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40415484
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.38038770
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33522405
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32367275
30	GABAergic synapse_Homo sapiens_hsa04727	1.31467047
31	Insulin secretion_Homo sapiens_hsa04911	1.26764249
32	Morphine addiction_Homo sapiens_hsa05032	1.25482734
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.20001532
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.17760990
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.15770378
36	African trypanosomiasis_Homo sapiens_hsa05143	1.13449787
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.12241333
38	Cocaine addiction_Homo sapiens_hsa05030	1.10868143
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09900520
40	Regulation of autophagy_Homo sapiens_hsa04140	1.09734135
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.05234936
42	Olfactory transduction_Homo sapiens_hsa04740	1.01871462
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99095717
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98309334
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.94989338
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93605323
47	Sulfur relay system_Homo sapiens_hsa04122	0.92411051
48	RNA degradation_Homo sapiens_hsa03018	0.91905758
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91746353
50	Proteasome_Homo sapiens_hsa03050	0.89884548
51	Basal cell carcinoma_Homo sapiens_hsa05217	0.89609082
52	Basal transcription factors_Homo sapiens_hsa03022	0.87939131
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.83979525
54	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83549276
55	Butanoate metabolism_Homo sapiens_hsa00650	0.83200529
56	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.82418393
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81691020
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81089338
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78093553
60	Amphetamine addiction_Homo sapiens_hsa05031	0.76671697
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76615000
62	Circadian entrainment_Homo sapiens_hsa04713	0.76297592
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75850897
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72759770
65	Sulfur metabolism_Homo sapiens_hsa00920	0.70783762
66	Caffeine metabolism_Homo sapiens_hsa00232	0.69647722
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65846877
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.65817686
69	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62365361
70	Propanoate metabolism_Homo sapiens_hsa00640	0.57762180
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57519263
72	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.57390147
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54735546
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.54501766
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.53824724
76	cAMP signaling pathway_Homo sapiens_hsa04024	0.52516529
77	Fatty acid elongation_Homo sapiens_hsa00062	0.52412023
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.52349083
79	One carbon pool by folate_Homo sapiens_hsa00670	0.52066956
80	Retinol metabolism_Homo sapiens_hsa00830	0.50351499
81	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49861725
82	Peroxisome_Homo sapiens_hsa04146	0.49190962
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48231240
84	Serotonergic synapse_Homo sapiens_hsa04726	0.46671934
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.46547295
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46354569
87	Metabolic pathways_Homo sapiens_hsa01100	0.44232928
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.44207683
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42087974
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37906922
91	Allograft rejection_Homo sapiens_hsa05330	0.37639165
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37151027
93	MAPK signaling pathway_Homo sapiens_hsa04010	0.36599925
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36290417
95	Axon guidance_Homo sapiens_hsa04360	0.34241085
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31037927
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.30530453
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.30352112
99	Asthma_Homo sapiens_hsa05310	0.29100436
100	Ras signaling pathway_Homo sapiens_hsa04014	0.28542548

KCNMB3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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